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Journal articles on the topic 'Extra survival time'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Arrese, D., E. Feria-Arias, H. Khabiri, et al. "Effect of extrahepatic disease on transarterial chemoembolization for metastatic carcinoid." Journal of Clinical Oncology 29, no. 4_suppl (2011): 283. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.283.

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283 Background: Transarterial chemoembolization (TACE) is the locoregional therapy of choice for the management of patients with inoperable carcinoid liver metastases. Often, metastatic disease is not limited to the liver. The impact of extra-hepatic metastases on response and outcomes following TACE has not been described. Objective: We hypothesized that patients who have extra-hepatic disease would have similar tumor response and symptom control following TACE. Methods: We reviewed 198 patients that underwent TACE for inoperable carcinoid liver metastases. Two groups were identified, those w

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Speidl, Walter S., Georg Goliasch, Christian Roth, et al. "ASSOCIATION OF VENOARTERIAL EXTRA-CORPOREAL MEMBRANE OXYGENATION CANNULATION SITE WITH WEANING TIME AND SURVIVAL." Journal of the American College of Cardiology 67, no. 13 (2016): 1431. http://dx.doi.org/10.1016/s0735-1097(16)31432-2.

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Herrmann, R. "Do We Survive with Survival Suits?" Journal of The Royal Naval Medical Service 74, no. 3 (1988): 147–52. http://dx.doi.org/10.1136/jrnms-74-147.

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AbstractThe availability of immersion suits on board merchant ships is recommended in 1983 Amendments to the international convention for the safety of life at sea, 1974 (IMO). Suits approved by the Federal German Republic were tested in a wave tank using an immersible dummy. Extra buoyancy in the head region was required to correct the horizontal floating position. Buoyancy from a life-jacket was preferred to other sources. At 1 m wave height, flooding time of the face varied from 0.3% for one suit to 100% for another. Suits lined with non-absorbent material gave the best results.

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BL, Ikhlov. "Physics of The Interaction Between Extra High Frequencies and Spiral Macromolecules." Journal of Preventive Medicine,Infectious Diseases & Therapy 1, no. 1 (2024): 1–7. https://doi.org/10.63721/25jpmidt0102.

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The formula for the natural frequency of torsional vibrations of the DNA helix is obtained by methods of mathematical physics. The data on the dependence of E. coli survival on the time of exposure to centimeter waves were analyzed, the numerical coefficient in the resulting formula was determined. According to this formula, the resonant frequency for the DNA of another strain of E. coli was found. When irradiated with centimeter waves of this frequency, a significant decrease in the survival rate of another strain of E. coli was obtained. Similar experiments on three other bacterial cultures

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Speelman, Jonathan P., Ki-Lam Hui, Nicolas T. Woodbridge, Susanne Pfeiffer, Julia A. Beatty, and Alan H. Taylor. "Prognostic Factors in 26 Cats Undergoing Surgery for Extra-Hepatic Biliary Obstruction." Veterinary Sciences 11, no. 12 (2024): 610. http://dx.doi.org/10.3390/vetsci11120610.

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Surgical management of feline extra-hepatic biliary obstruction (EHBO) has poor survival rates with few prognostic factors reported in the literature. The etiology and clinical findings of feline EHBO and their influence on short-(2 weeks–6 months) and long-term (>6 months) survival and prognosis were examined in an observational clinical retrospective study of 26 client-owned cats undergoing surgery for biliary obstruction at one institution between 2012 and 2020. The etiology of EHBO was determined in 21/26 cats, which included inflammatory causes (14/21), neoplastic causes (6/21), and a

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Appleton, ND, D. Bosanquet, G. Morris-Stiff, H. Ahmed, P. Sanjay, and MH Lewis. "Extra-anatomical bypass grafting – a single surgeon's experience." Annals of The Royal College of Surgeons of England 92, no. 6 (2010): 499–502. http://dx.doi.org/10.1308/003588410x12664192076890.

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INTRODUCTION Extra-anatomical bypass grafting is a recognised method of lower limb re-vascularisation in high-risk patients who cannot tolerate aortic cross clamping, or in those with a hostile abdomen. We present a single surgeon series of such procedures and determine relevant outcomes. PATIENTS AND METHODS A retrospective review was performed on a prospectively maintained database of patients undergoing femoro-femoral or axillo-femoral bypass surgery between 1986 and 2004. RESULTS Patency rates for femoral (n = 28; 32%) versus axillary (n = 59; 68%) bypass procedures at 1 month, 1, 3 and 5

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Roskamp, Liliane, Camila Paiva Perin, Juliana Pierdoná de Castro, et al. "Retrospective analysis of survival of avulsed and replanted permanent teeth according to 2012 or 2020 IADT Guidelines." Brazilian Dental Journal 34, no. 2 (2023): 122–28. http://dx.doi.org/10.1590/0103-6440202305255.

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Abstract This study aimed to compare the survival of replanted teeth that followed the 2012 or the 2020 International Association of Dental Traumatology (IADT) guidelines. Sixty-two permanent replanted teeth were retrospectively assessed (IADT 2012, n = 45; IADT 2020, n = 17). Five years after replantation (from January 2017 to December 2021), clinical and radiographic examinations were performed. A significance level of 95% was considered to evaluate the outcomes. Thirty-one teeth (50.0%) remained in their sockets and 31 (50.0%) were lost due to external root resorption. Of the 25 (40.3%) tee

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Alnaami, Ibrahim, Juliana VanderPluym, Albert Murtha, et al. "The Potential Impact of Delayed Radiation Therapy on Patients with Glioblastoma." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 40, no. 6 (2013): 790–94. http://dx.doi.org/10.1017/s0317167100015900.

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Background:Radiation therapy (RT) is the major component of glioblastoma treatment; however, the time to initiate RT after surgical intervention varies between institutions. Our study examined the time from diagnosis to the initiation of RT and its effects on overall patient survival.Methods:We retrospectively examined 267 patients with glioblastoma who received RT as part of their therapy in two Canadian tertiary care centers. The primary goal of the study is to assess if time to RT can predict/impact survival in glioblastoma patients.Results:The following variables were associated with an in

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Peterson, Michael, Brianna Eillen Ramos, Jasika Grover, et al. "Extra-adrenal paraganglioma demographic data: A NCDB study." Journal of Clinical Oncology 42, no. 16_suppl (2024): e16293-e16293. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e16293.

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e16293 Background: Extra-adrenal paragangliomas are rare neuroendocrine tumors that form near blood vessels and nerves outside of adrenal glands. Despite their rare occurrence, these tumors have higher rates of malignancy and varying survival rates compared to other paragangliomas. To better understand its epidemiology, there may be clinical value in analyzing the diagnostic trends of these tumors. This study utilized information provided by the National Cancer Database (NCDB) to examine the demographic factors of patient populations diagnosed with extra-adrenal paragangliomas. Methods: A retr

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Zhang, Yuanyuan, Jonathan Schoenhals, Alana Christie, et al. "Outcomes of stereotactic ablative radiotherapy for extra-cranial oligo-metastatic renal cell cancer." Journal of Clinical Oncology 37, no. 7_suppl (2019): 599. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.599.

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599 Background: Stereotactic ablative radiotherapy (SAbR) is a standard of care for treating renal cell cancer (RCC) cranial metastasis. We describe the effect of SAbR on oligometastatic extra-cranial RCC disease course. Methods: We retrospectively reviewed 49 patients with oligometastatic RCC with 68 extra-cranial lesions. Patients were treated with SAbR with a curative intent from 2007 to 2017. We analyzed local control, systemic therapy free survival (mPFS), and overall survival. Results: With a median follow-up of 28 months (IQR: 16.0-40.3), the 1-year and 2-year overall survival after SAb

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Manciu, Marian, Sorour Hosseini, and Joscelyne Guzman-Gonzalez. "A Maximum Entropy Estimator for the Average Survival Time Differences between Two Groups." Clinical Cancer Drugs 7, no. 2 (2020): 107–12. http://dx.doi.org/10.2174/2212697x07999200331120654.

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Background: Statistical methods commonly used in survival analysis typically provide the probability that the difference between groups is due to chance, but do not offer a reliable estimate of the average survival time difference between groups (the difference between median survival time is usually reported). Objective: We suggest a Maximum-Entropy estimator for the average Survival Time Difference (MESTD) between groups. Methods: The estimator is based on the extra survival time, which should be added to each member of the group, to produce the maximum entropy of the result (resulting in th

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Marrano, Nicola, Rosaria Spagnuolo, Giuseppina Biondi, et al. "Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival." Plants 10, no. 2 (2021): 286. http://dx.doi.org/10.3390/plants10020286.

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Extra virgin olive oil (EVOO) is a major component of the Mediterranean diet and is appreciated worldwide because of its nutritional benefits in metabolic diseases, including type 2 diabetes (T2D). EVOO contains significant amounts of secondary metabolites, such as phenolic compounds (PCs), that may positively influence the metabolic status. In this study, we investigated for the first time the effects of several PCs on beta-cell function and survival. To this aim, INS-1E cells were exposed to 10 μM of the main EVOO PCs for up to 24 h. Under these conditions, survival, insulin biosynthesis, gl

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Curtis, Jacob M. T., Emma C. Foster, Sankaranarayanan Ananth, et al. "Autotransplantation of a surgically removed canine using a customised 3D-printed surgical template." Journal of Orthodontics 47, no. 1 (2020): 82–90. http://dx.doi.org/10.1177/1465312519891738.

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Autotransplantation is a treatment option with high reported survival rates to replace failing teeth in the anterior maxilla. This treatment requires a multidisciplinary approach from orthodontists, paediatric dentists, restorative dentists, and oral and maxillofacial surgeons to achieve successful outcomes. Success is dependent on many factors including stage of root development, handling of the periodontal ligament, extra-alveolar time and splinting. This case report presents the novel use of digitally designed and three-dimensional (3D) printed surgical templates to aid intraoperatively and

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Kapacee, Zainul-Abedin, Jennifer Allison, Mohammed Dawod, et al. "The Management and Outcomes of Patients with Extra-Pulmonary Neuroendocrine Neoplasms and Brain Metastases." Current Oncology 29, no. 7 (2022): 5110–25. http://dx.doi.org/10.3390/curroncol29070405.

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Background: Brain metastases (BMs) in patients with extra-pulmonary neuroendocrine neoplasms (EP–NENs) are rare, and limited clinical information is available. The aim of this study was to detail the clinicopathological features, management and outcomes in patients with EP–NENs who developed BMs. Methods: A retrospective single-centre analysis of consecutive patients with EP–NENs (August 2004–February 2020) was conducted. Median overall survival (OS)/survival from BMs diagnosis was estimated (Kaplan–Meier). Results: Of 730 patients, 17 (1.9%) had BMs, median age 61 years (range 15–77); 8 (53%)

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Sajous, Christophe, Julien Peron, Helen Jane Boyle, et al. "Efficacy of antiangiogenic renal neoplasm with bone metastasis: A mono-institutional study in France." Journal of Clinical Oncology 36, no. 6_suppl (2018): 610. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.610.

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610 Background: Although bone metastases occur frequently in metastatic renal cell carcinoma (mRCC) and represent approximatively 20-30% of the different sites of metastases, few studies have assessed the prognostic impact of these metastatic sites. In this context, the aim of our study was to evaluate the efficiency of antiangiogenic (AA) treatments in this particular site Methods: A retrospective review of patients with mRCC and bone metastases, treated with a first line of antiangiogenic therapy at the Centre Leon Berard (CLB) was conducted between January 2010 and November 2016. In order t

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Etheridge, A. M., та D. R. E. Williams. "A decomposition of the (1 + β)-superprocess conditioned on survival". Proceedings of the Royal Society of Edinburgh: Section A Mathematics 133, № 4 (2003): 829–47. http://dx.doi.org/10.1017/s0308210500002699.

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There is a large catalogue of decompositions of conditioned superprocesses in terms of an ‘immortal backbone’ or ‘skeleton’ along the branches of which mass is constantly immigrated. We add to this with a study of the (infinite-variance) (1 + β)-superprocess, conditioned on survival until some fixed time T. As one would expect, we see a Poisson number of immortal trees (conditioned on there being at least one), along which mass (conditioned to die before time T) is immigrated. However, here we see a new source of immigration. Not only is mass immigrated along the branches of the immortal trees

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Muzvondiwa, Eresi. "Livelihood and survival strategies among Gweru urban teachers and their implications on pupils’ performance in the current Zimbabwe’s flopping economy." Technium Social Sciences Journal 7 (April 26, 2020): 74–85. http://dx.doi.org/10.47577/tssj.v7i1.356.

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Currently, teachers’ salaries in Zimbabwe are insufficient to sustain the harsh economic situation yet teachers seem to be meeting their monthly livelihood demands. A study to explore different survival strategies engaged by teachers under this current flopping economy was conducted in the Gweru urban. A total of 55 participants were randomly selected from five different schools. Questionnaires and in-depth interviews were used to collect data. Descriptive statistics and Chi-Square test for association (SPSS version 21) were used to analyse the data. Findings revealed that teachers have adopte

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Thomes, Reggie M., Benjamin Marshall Parsons, Andrew J. Borgert, and Susan M. Frankki. "Treatment outcomes of stage IE intestinal extra-nodal marginal zone lymphoma: A National Cancer Database study." Journal of Clinical Oncology 39, no. 15_suppl (2021): e19530-e19530. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e19530.

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e19530 Background: Extra-nodal marginal zone lymphoma is a rare, indolent non-Hodgkin lymphoma. Classically it involves the gastric mucosa and is associated with chronic infection, but it can also be found in the lower gastrointestinal (GI) tract. No standard therapy has been established for early stage disease in the small intestine, colon or rectum though multiple strategies have been employed. Little is known regarding the natural history and long-term outcomes of this disease when confined to the lower GI tract. We used the National Cancer Database (NCDB) to evaluate this patient populatio

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Cormio, G., C. Rossi, A. Cazzolla, et al. "Distant metastases in ovarian carcinoma." International Journal of Gynecologic Cancer 13, no. 2 (2003): 125–29. http://dx.doi.org/10.1136/ijgc-00009577-200303000-00004.

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Distant metastases are unusual at presentation and during the course of ovarian carcinoma. The aim of the present study was to determine the incidence and prognostic factors of distant metastases consistent with stage IV disease in ovarian cancer patients. A retrospective chart review was conducted on 162 patients with epithelial ovarian carcinoma treated at our Unit between 1991 and 2000. Pertinent clinical information, pathologic data, treatment, and prognostic factors for survival following documentation of distant metastatic disease were collected. The significance of the association betwe

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Kukreti, Vishal, Peter Petersen, Melania Pintilie, Richard Tsang, Michael Crump, and Mary Gospodarowicz. "Extranodal Follicular Lymphoma - a Retrospective Review and Comparison with Localized Nodal Follicular Lymphoma." Blood 104, no. 11 (2004): 1375. http://dx.doi.org/10.1182/blood.v104.11.1375.1375.

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Abstract Follicular lymphoma arising in an extranodal site is uncommon and its natural history and treatment is poorly characterized in the literature. We retrospectively reviewed a large cohort of patients with stage I and II follicular lymphoma and analyzed the outcomes of patients with extranodal (EN-FL) presentations to identify sites of involvement and treatment outcome, and compared these to patients with nodal follicular lymphoma. From 1967 to 1999, 668 cases of limited stage follicular lymphoma (stage I and II) were treated at the Princess Margaret Hospital. Of these, 157 cases (23.5%)

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Demikh, Oğuzhan. "Marine Survival Artists: How Sea Creatures Adapt to Extreme Environments." Journal Siplieria Sciences 4, no. 4 (2023): 25–30. http://dx.doi.org/10.48173/jss.v4i4.236.

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This quantitative take a look at explores the relationships between observe hours and exam scores amongst college college students, utilizing descriptive facts for evaluation. Findings from a pattern of 50 contributors screen a median observe time of 12.4 hours, indicating a various variety of have a look at conduct with a preferred deviation of 4.2. Exam rankings exhibit a mean of 75.6, showcasing variability with a popular deviation of 10. Eight. The consequences underscore a nuanced connection among look at conduct and academic performance, emphasizing the want for tailor-made instructional

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Liu, Jacie Jia. "A Study on Link Functions for Modelling and Forecasting Old-Age Survival Probabilities of Australia and New Zealand." Risks 9, no. 1 (2021): 11. http://dx.doi.org/10.3390/risks9010011.

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Forecasting survival probabilities and life expectancies is an important exercise for actuaries, demographers, and social planners. In this paper, we examine extensively a number of link functions on survival probabilities and model the evolution of period survival curves of lives aged 60 over time for the elderly populations in Australasia. The link functions under examination include the newly proposed gevit and gevmin, which are compared against the traditional ones like probit, complementary log-log, and logit. We project the model parameters and so the survival probabilities into the futu

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Barriga, Gladys DC, Vicente G. Cancho, Daniel V. Garibay, Gauss M. Cordeiro, and Edwin MM Ortega. "A new survival model with surviving fraction: An application to colorectal cancer data." Statistical Methods in Medical Research 28, no. 9 (2018): 2665–80. http://dx.doi.org/10.1177/0962280218786053.

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We propose a new survival model for lifetime data in the presence of surviving fraction and obtain some of its properties. Its genesis is based on extensions of the promotion time cure model, where an extra parameter controls the heterogeneity or dependence of an unobserved number of lifetimes. We construct a regression model to evaluate the effects of covariates in the cured fraction. We discuss inference aspects for the proposed model in a classical approach, where some maximum likelihood tools are explored. Further, an expectation maximization algorithm is developed to calculate the maximum

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French-Monar, Ronald D., Jeffrey B. Jones, Monica Ozores-Hampton, and Pamela D. Roberts. "Survival of Inoculum of Phytophthora capsici in Soil Through Time Under Different Soil Treatments." Plant Disease 91, no. 5 (2007): 593–98. http://dx.doi.org/10.1094/pdis-91-5-0593.

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From September 2001 until August 2002 and from September 2002 until August 2003, inoculum of Phytophthora capsici consisting of mycelium and oospores was buried in soil under three different soil treatments: soil solarization, fumigation with methyl bromide and chloropicrin, and white-on-black plastic mulch without fumigation or solarization. The effect of these soil treatments on the population and survival of P. capsici was evaluated through time after 28, 63, 119, 175, 245, and 343 days. Three techniques were used for detection of the localized inoculum in soil: soil dilution plating (SDP),

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Ireland, Richard W. "Absence of Evidence or Evidence of Absence? Welsh Extra-Curial Dispute Settlement Revisited." Welsh History Review / Cylchgrawn Hanes Cymru 30, no. 1 (2020): 56–87. http://dx.doi.org/10.16922/whr.30.1.4.

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The 'ceffyl pren' ('wooden horse') was a ritual shaming punishment used by neighbours against offenders who were held to have breached communal norms. The use of the practice in the nineteenth century is often presented as a survival of a long-established custom, rooted in rural Welsh life and in decline due to suppression by the instruments of the state. This article argues that the ceffyl pren was not in its origin ancient, nor particularly Welsh, and that its use increased in the nineteenth century. The reasons for the development of the practice at that later time are then considered.

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Ng, Lawrence Cheng Kiat, Shin Yeu Ong, Xinxin Huang, et al. "Outcome of Extra-Nodal Follicular Lymphoma Affected By Selection of Induction Chemoimmunotherapy and Maintenance Rituximab - Real-World Retrospective Study." Blood 144, Supplement 1 (2024): 6277. https://doi.org/10.1182/blood-2024-193417.

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Background: Extra-nodal involvement is frequently observed in follicular lymphoma, yet there is limited evidence regarding its prognostic significance and optimal treatment strategies. We present our institutional experience treating follicular lymphoma, focusing on the impact of extra-nodal involvement. Methods: We conducted a retrospective analysis of demographic, treatment, and outcome data from patients with follicular lymphoma treated at two major cancer institutions in Singapore from 2010 to 2023, using registry data. Patients with grade 3B histology were excluded. Progression-free survi

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Hatzaras, Ioannis, Michael A. Choti, Richard D. Schulick, et al. "Patterns of recurrence after resection of intrahepatic cholangiocarcinoma: Results from a multi-institutional cohort of 449 patients." Journal of Clinical Oncology 30, no. 4_suppl (2012): 267. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.267.

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267 Background: Outcomes following surgical management of intrahepatic cholangiocarcionma (ICC) have largely focused on overall survival. Data on recurrence following surgery for ICC are limited. We sought to investigate rates and patterns of recurrence in patients following curative intent surgery for ICC. Methods: 449 patients who underwent surgery for ICC between 1973 and 2010 were identified from an international multi-institutional database. Clinicopathologic data, recurrence patterns, and recurrence-free survival (RFS) were analyzed. Results: Most patients had a solitary tumor (70%) with

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Wang, Chiachien Jake, Xin Cai, Dong W. Kim, et al. "The effect of stereotactic ablative radiotherapy on time to change of systemic therapy in extra-cranial renal cell carcinoma metastases." Journal of Clinical Oncology 34, no. 2_suppl (2016): 533. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.533.

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533 Background: Renal cell carcinoma (RCC) has traditionally been refractory to radiotherapy with conventional fractionation, although recent evidence suggests a response to higher doses per fraction. We evaluated local control of extra-cranial metastases from RCC treated with stereotactic ablative radiotherapy (SABR). Methods: RCC patients with extra-cranial metastases treated with SABR were retrospectively enrolled from a single institution between 2005 and 2015. A total of 188 lesions were identified from 91 patients. Radiation (8-60Gy) was delivered in 1-5 fractions (fx) using stereotactic

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SANDBERG, MARIANNE, MERETE HOFSHAGEN, ØYVIN ØSTENSVIK, EYSTEIN SKJERVE, and GILES INNOCENT. "Survival of Campylobacter on Frozen Broiler Carcasses as a Function of Time." Journal of Food Protection 68, no. 8 (2005): 1600–1605. http://dx.doi.org/10.4315/0362-028x-68.8.1600.

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In the Norwegian Action Plan against Campylobacter in broilers, carcasses from flocks identified as positive before slaughter are either heat treated or frozen for 5 weeks to reduce the number of Campylobacter. The objective of this study was to estimate the effect of freezing time and predict the number of Campylobacter on naturally infected or contaminated broiler carcasses following freezing for 2, 4, 6, 8, 10, 13, 21, 35, and 120 days by nonparametric and parametric linear statistical models. From each of the five flocks, 27 carcasses were sampled. Each carcass was cut in two pieces along

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Cabibbo, Giuseppe, Alessandro Cucchetti, Calogero Cammà, et al. "Outcomes of hepatocellular carcinoma patients treated with sorafenib: a meta-analysis of Phase III trials." Future Oncology 15, no. 29 (2019): 3411–22. http://dx.doi.org/10.2217/fon-2019-0287.

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Aim: To benchmark overall survival (OS) and time to radiological progression (TTP) of patients enrolled in randomized controlled trials (RCTs) assessing sorafenib in advanced hepatocellular carcinoma using individual participant survival data, and to meta-analyze prognostic factors for OS and TTP. Methods: RCTs were identified through literature search until December 2018. Individual participant survival was reconstructed with an algorithm from published Kaplan–Meier curves. Results: Ten RCTs were included. Median OS was 10.0 months (95% CI: 9.6–10.5), and median TTP was 4.1 months (95% CI: 3.

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Abedin Kapacee, Zainul, Mohammed Dawod, Jennifer Allison, et al. "NCMP-04. INCIDENCE AND OUTCOMES OF BRAIN METASTASES IN PATIENTS WITH EXTRA-PULMONARY NEUROENDOCRINE NEOPLASMS." Neuro-Oncology 22, Supplement_2 (2020): ii123—ii124. http://dx.doi.org/10.1093/neuonc/noaa215.516.

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Abstract BACKGROUND Brain metastases (BMs) incidence in patients with extra-pulmonary neuroendocrine neoplasms (EP-NENs) is unclear, with no available management recommendations. This study aimed to review the clinical presentation, management and survival outcomes of patients with EP-NENs and BMs at a European Centre of Excellence. METHODS A retrospective single-centre analysis of consecutive patients with EP-NENs (Aug 2004-Feb 2020) was conducted. Median overall survival (OS)/survival from BMs diagnosis were estimated (Kaplan Meier). RESULTS Of 786 patients, 15 (1.9%) had BMs, median age 61y

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Grimley, P. M., R. Matsuno, and W. F. Anderson. "Population profiles of extra-ovarian and ovarian serous adenocarcinomas: Comparisons with grade stratification." Journal of Clinical Oncology 27, no. 15_suppl (2009): e16506-e16506. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e16506.

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e16506 Background: Molecular studies of ovarian serous adenocarcinomas (OSC) have linked distinct patterns of gene expression or mutations to high or low tumor grade. This heterogeneity appears to be mirrored in two population subgroups delineated by age-specific incidence rates (ASIR) stratified by grade. We aimed to determine whether serous adenocarcinomas of the peritoneum (PSC) or fallopian tubes (FSC) comprised grade-related subgroups comparable to OSC. Methods: Data for women with invasive OSC (25,997 cases), PSC (2,157), and/or FSC (618) registered in the NCI's Surveillance, Epidemiolog

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Mduma, Estomih, Jan Terje Kvaløy, Eldar Soreide, et al. "Frequent refresher training on newborn resuscitation and potential impact on perinatal outcome over time in a rural Tanzanian hospital: an observational study." BMJ Open 9, no. 9 (2019): e030572. http://dx.doi.org/10.1136/bmjopen-2019-030572.

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ObjectivesGlobally, perinatal mortality remains high, especially in sub-Saharan countries, mainly because of inadequate obstetric and newborn care. Helping Babies Breathe (HBB) resuscitation training as part of a continuous quality improvement (CQI) programme may improve outcomes. The aim of this study was to describe observed changes in perinatal survival during a 6-year period, while adjusting for relevant perinatal risk factors.SettingDelivery rooms and operating theatre in a rural referral hospital in northern-central Tanzania providing comprehensive obstetric and basic newborn care 24 hou

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Bichet, Coraline, Dominique Allainé, Sandrine Sauzet, and Aurélie Cohas. "Faithful or not: direct and indirect effects of climate on extra-pair paternities in a population of Alpine marmots." Proceedings of the Royal Society B: Biological Sciences 283, no. 1845 (2016): 20162240. http://dx.doi.org/10.1098/rspb.2016.2240.

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Despite being identified an area that is poorly understood regarding the effects of climate change, behavioural responses to climatic variability are seldom explored. Climatic variability is likely to cause large inter-annual variation in the frequency of extra-pair litters produced, a widespread alternative mating tactic to help prevent, correct or minimize the negative consequences of sub-optimal mate choice. In this study, we investigated how climatic variability affects the inter-annual variation in the proportion of extra-pair litters in a wild population of Alpine marmots. During 22 year

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Kajikawa, Patricia, Ilka de Fátima Santana Ferreira Boin, Helbert Oliveira Manduca Palmiero, and Helder Zambelli. "Analysis of liver recipients survival with donor risk index (dri): a prospective study of cadaveric donors from OPO-HC-UNICAMP and their receptors." Brazilian Journal of Transplantation 16, no. 4 (2013): 1810–13. http://dx.doi.org/10.53855/bjt.v16i4.168.

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Introduction: In 2006, a donor risk index (DRI) was published based on data such as age, race, height, cause of brain death, cardio respiratory arrest, split-organ and ischemia time. Purpose: To study the survival rate of liver recipient with DRI. Method: This is an analytic and prospective study. The characteristics from the liver donor were: age (years), race (white/ black/Asian), height (cm), cause of brain death (anoxia, trauma, stroke or tumor), presence of cardiac arrest, cold ischemia time and procurement place (local, regional or national). The liver recipients’ characteristics were: a

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Carceller, Fernando, Francisco Bautista, Alicia Castañeda, et al. "Mortality and survival rates in children and adolescents enrolled in early phase trials with a dose-finding/dose-confirmation component: An innovative therapies for children with cancer (ITCC) study." Journal of Clinical Oncology 37, no. 15_suppl (2019): e21509-e21509. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e21509.

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e21509 Background: Participation of children with advanced solid cancers in phase I trials raises ethical and logistic dilemmas. Life-expectancy beyond 8-12 weeks is a common inclusion criterion, but it can be difficult to gauge. This multicentric European study assessed the mortality and survival rates in pediatric phase I trials. Methods: Retrospective study of patients aged < 18 years with solid tumors enrolled in phase I trials in ITCC centres between 2015-2017. Outcome variables were described and prognostic factors analysed. Results: 256 patients across 12 centres in 5 countries were

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Porta, Matteo G. Della, Andrea Kuendgen, Luca Malcovati, et al. "Myelodysplastic Syndrome (MDS)-Specific Comorbidity Index for Predicting the Impact of Extra-Hematological Comorbidities on Survival of Patients with MDS." Blood 112, no. 11 (2008): 2677. http://dx.doi.org/10.1182/blood.v112.11.2677.2677.

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Abstract Myelodysplastic syndromes (MDS) occur mainly in older persons, who are likely to be affected with extra-hematological comorbidities. Recent findings suggest that proper assessment of comorbidities is useful to predict the outcome of MDS patients receiving allogeneic transplantation. However, the results obtained in this highly selected subset of patients cannot be applied to the whole MDS population. In this study, we evaluated the impact of extra-hematological comorbidities on the natural history of MDS with the aim of developing a specific prognostic index. The patients comprised a

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Colombo, Nicoletta. "Efficacy of Trabectedin in Platinum-Sensitive-Relapsed Ovarian Cancer: New Data From the Randomized OVA-301 Study." International Journal of Gynecologic Cancer 21, Supp 1 (2011): S12—S16. http://dx.doi.org/10.1097/igc.0b013e318217b321.

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The results of the OVA-301 study show that trabectedin in combination with pegylated liposomal doxorubicin (PLD) results in improved progression-free survival and response rate in patients with advanced ovarian cancer. The trial has also demonstrated a trend toward improvement in overall survival. A subgroup analysis indicates that in the subset of patients with platinum-free interval (PFI) of 6 to 12 months, the combined treatment resulted in a 6-month improvement in overall survival. Furthermore, in the patients who have received third-line treatment with a platinum agent, it was found that

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Gusani, Niraj J., J. Wallis Marsh, Michael A. Nalesnik, Mitchell E. Tublin, and T. Clark Gamblin. "Carcinoid of the Extra-Hepatic Bile Duct: A Case Report with Long-Term Follow-up and Review of Literature." American Surgeon 74, no. 1 (2008): 87–90. http://dx.doi.org/10.1177/000313480807400121.

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Extrahepatic bile duct tumors, 80 per cent of which are adenocarcinomas, are rare neoplasms accounting for less than two per cent of all cancers. Carcinoid tumor of the extrahepatic bile ducts is a reportable lesion, with only approximately 50 cases described in the literature since 1959. We present a case of a primary extrahepatic bile duct carcinoid tumor resected for cure with the longest reported follow-up time (11 years) after surgery. We also summarize the existing literature with regard to this rare tumor. Our case lends strong support to the notion that extrahepatic biliary carcinoids

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Saeed, Amna, Asim Waris, Ahmed Fuwad, et al. "Random survival forest model for early prediction of Alzheimer’s disease conversion in early and late Mild cognitive impairment stages." PLOS ONE 19, no. 12 (2024): e0314725. https://doi.org/10.1371/journal.pone.0314725.

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With a clinical trial failure rate of 99.6% for Alzheimer’s Disease (AD), early diagnosis is critical. Machine learning (ML) models have shown promising results in early AD prediction, with survival ML models outperforming typical classifiers by providing probabilities of disease progression over time. This study utilized various ML survival models to predict the time-to-conversion to AD for early (eMCI) and late (lMCI) Mild Cognitive Impairment stages, considering their different progression rates. ADNI data, consisting of 291 eMCI and 546 lMCI cases, was preprocessed to handle missing values

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Oka, Hidehiro, Mari Kusumi, Masafumi Koremura, and Koji Kondo. "CS-09 Extra-parenchymal (Peripheral) Atypical Teratoid / Rhabdoid Tumors." Neuro-Oncology Advances 2, Supplement_3 (2020): ii20—ii21. http://dx.doi.org/10.1093/noajnl/vdaa143.090.

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Abstract AT/RT is a malignant embryonal tumor reported by Rorke in 1996. Authors reported first AT/RT in Japan in 1998. This tumor entity was included as new malignant embryonal tumor in WHO 2000, and tumors of Japanese patients has been reported more than 80 cases in the past. This AT/RT is a tumor in the brain parenchyma that a medulloblastoma and PNET and the possibility that it has been misdiagnosed have had pointed out. On the other hand, it is reported that there is the type that we should call peripheral AT/RT which rarely occurs in extra-parenchyma. We want to propose that there is suc

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Oka, Hidehiro, Mari Kusumi, Koji Kondo, and Masafumi Koremura. "CS-05 EXTRA-PARENCHYMAL (PERIPHERAL) ATYPICAL TERATOID / RHABDOID TUMORS." Neuro-Oncology Advances 1, Supplement_2 (2019): ii39. http://dx.doi.org/10.1093/noajnl/vdz039.176.

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Abstract AT/RT is a malignant embryonal tumor reported by Rorke in 1996. Authors reported first AT/RT in Japan in 1998. This tumor entity was included as new malignant embryonal tumor in WHO 2000, and tumors of Japanese patients has been reported more than 60 cases in the past. This AT/RT is a tumor in the brain parenchyma that a medulloblastoma and PNET and the possibility that it has been misdiagnosed have had pointed out. On the other hand, it is reported that there is the type that we should call peripheral AT/RT which rarely occurs in extra-parenchyma. We want to propose that there is suc

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Bishnoi, Rohit, Chintan Shah, Jan Moreb, and Hemant S. Murthy. "Single Center Real-World Experience of Daratumumab and Extra-Medullary Myeloma." Blood 132, Supplement 1 (2018): 5668. http://dx.doi.org/10.1182/blood-2018-99-119829.

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Abstract Background: Daratumumab (Dara) was recently FDA approved for the treatment of relapsed/refractory multiple myeloma (RRMM). We evaluated a real-world single-center experience of Dara salvage therapy for RRMM. Methods: Patients treated at the University of Florida with Dara for RRMM between January 2016 and February 2018 were included. Data was collected by chart review and analyzed for patient demographics, disease characteristics, treatment, and outcomes. Results: 25 patients (13 as monotherapy and 12 in combination) were included, with a median age of 63 (range, 42-86) years. Median

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Lynch, Sophie, Omar Al-Salihi, Vishal Manik, et al. "STEREOTACTIC RADIOSURGERY FOR BRAIN METASTASES FROM GASTROINTESTINAL PRIMARIES: ANALYSIS OF OUTCOMES." Neuro-Oncology 25, Supplement_3 (2023): iii21. http://dx.doi.org/10.1093/neuonc/noad147.089.

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Abstract AIMS Brain metastases from gastrointestinal primaries are uncommon with poor reported outcomes following SRS. We evaluated clinical outcomes for patients diagnosed with metastatic brain tumours from a gastrointestinal primary treated with stereotactic radiosurgery (SRS). METHOD A single institutional retrospective review of patients treated with LINAC-based SRS at our institution between 2017 and 2022. Median survival was calculated from the time of SRS. RESULTS A total of 24 patients were treated with primary malignancy locations as follows: 10 colon, 7 rectum and 7 oesophageal. Medi

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López-Contreras, Andres J., Paula Gutierrez-Martinez, Julia Specks, Sara Rodrigo-Perez, and Oscar Fernandez-Capetillo. "An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation." Journal of Experimental Medicine 209, no. 3 (2012): 455–61. http://dx.doi.org/10.1084/jem.20112147.

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Replicative stress (RS) is a type of endogenous DNA damage that cells suffer every time they duplicate their genomes, and which is further boosted by oncogenes. In mammals, the RS response (RSR) is coordinated by ATR and Chk1 kinases. We sought to develop a mammalian organism that is selectively protected from RS. To this end, mice carrying an extra copy of the Chk1 gene were generated. In vitro, Chk1 transgenic cells are protected from RS-inducing agents. Moreover, an extra Chk1 allele prolongs the survival of ATR-Seckel mice, which suffer from high levels of RS, but not that of ATM-deficient

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Torassa, Daniel, Pablo Naldini, José Luis Calvo-Guirado, and Enrique Fernández-Bodereau. "Prospective, Clinical Pilot Study with Eleven 4-Mm Extra-Short Implants Splinted to Longer Implants for Posterior Maxilla Rehabilitation." Journal of Clinical Medicine 9, no. 2 (2020): 357. http://dx.doi.org/10.3390/jcm9020357.

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In many clinical situations, rehabilitation with implants in the posterior maxillary region is complicated by limited bone availability. In this context, the use of 4 mm long implants (known as extra-short implants) may be used thanks to the concept of osseointegration enhancement. It has been demonstrated that short implants offer an alternative to the regeneration procedures involved in placing longer implants in areas where bone height is compromised. This prospective pilot study tested a treatment protocol in which 11 extra-short (4 mm) implants were splinted to 11 mesially placed longer (

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Tyulenev, Aleksey V., Galina V. Smirnova, Anna O. Gabova, Galina A. Triandafilova, and Oleg N. Oktyabrsky. "Real-time monitoring of physiological parameters in the study of Escherichia coli early response to peroxide stress." Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology, no. 1 (2022): 35–41. http://dx.doi.org/10.17072/1994-9952-2022-1-35-41.

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The response of aerobically growing Escherichia coli cultures to peroxide stress was studied using synchronous real-time monitoring of parameters pO2 (oxygen partial pressure), pH, Eh (redox potential of the culture), extracellular levels of K+ and S2-, in combination with traditional physiological, biochemical and genetic methods. A sharp increase in pO2 level in the medium caused by the destruction of H2O2 by endogenous catalases was observed in the early response to peroxide stress. The addition of 100 µM H2O2 provoked a reversible decrease in the specific growth rate, accompanied by an inc

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Wei, Alice Chia-chi, Natalie G. Coburn, Carol-anne Moulton, et al. "A phase II multicenter study of metastasectomy for intra- and extra-hepatic metastases from colorectal cancer." Journal of Clinical Oncology 31, no. 4_suppl (2013): 482. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.482.

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482 Background: Metastasectomy for liver limited metastases from colorectal cancer (CRC) provides excellent 5-year overall survival (OS) rates. The presence of extra-hepatic metastases (EHM) has traditionally been a contraindication to surgery. On this basis, as many as 80% of patients are deemed ineligible for liver resection. Due to the improved safety of hepatic surgery, there is a growing interest in multi-site metastasectomy for patients with intra-hepatic and extra-hepatic metastases (IHM, and EHM). The objective of this study was to evaluate the results of complete metastasectomy for pa

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Peng, Chen, Qiufen Guo, Tingting Zhang, et al. "Maintenance therapy for patients with recurrent or metastatic cervical cancer: A multicentre, cohort study." Journal of Clinical Oncology 41, no. 16_suppl (2023): e17518-e17518. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e17518.

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e17518 Background: Maintenance therapy with alternative agents after chemotherapy was shown to improve the overall survival in some advanced cancers such as breast cancer, lung cancer, ovarian cancer and so on. However, maintenance therapy is not accepted as the standard treatment for recurrent/metastatic cervical cancer. Aim of this study is to elucidate the efficacy of maintenance therapy in cervical cancer and to explore the factors associated with the prognosis of recurrent or metastatic cervical cancer. Methods: In this multicenter cohort study, we retrospectively collected patients with

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Cadranel, J., E. Quoix, P. Debove, et al. "IFCT0401 trial: Phase II study of gefitinib administered as first line treatment in non-resectable, pneumonic-type adenocarcinoma (P-ADC)." Journal of Clinical Oncology 24, no. 18_suppl (2006): 7186. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.7186.

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7186 Background: P-ADC is a peripheral lung ADC with a pneumonic radiological presentation, most often containing the bronchioloalveolar carcinoma variant in the 2004 classification. In this setting, EGF receptor tyrosine kinase inhibitors have shown promise. We therefore conducted a prospective multicentric phase II trial to evaluate gefitinib (G) (250 mg/d) as first line treatment in non-resectable P-ADC. Methods: Inclusion criteria: previously untreated, non-resectable cyto/pathologically proven P-ADC with > 3-month expected survival. Primary objective: disease control rate (DCR) - objec

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