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Dissertations / Theses on the topic 'Extracellular matrix proteins'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 August 2024

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1

Yi, Ming. "Extracellular matrix proteins and angiogenesis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3091204.

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2

Wendel, Mikael. "Skeletal tissue proteins isolation and characterization of novel extracellular matrix proteins /." Lund : Dept. of Medical and Physiological Chemistry, University of Lund, 1994. http://books.google.com/books?id=zvtqAAAAMAAJ.

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3

Chan, Cheuk-ming. "Controlled protein release from collagen matrix." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B3955868X.

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4

Avella, Charlotte Sinclair. "Strain related differential regulation of tendon extracellular matrix proteins." Thesis, Royal Veterinary College (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558956.

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5

Garcia, John Francis. "The role of extracellular matrix proteins in epithelial tumorigenesis /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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6

Shen, Zhenxin. "Expression and localization of extracellular matrix proteins in skeletal development." Lund : Dept. of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, 1998. http://books.google.com/books?id=Xe9qAAAAMAAJ.

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7

St, John Joni J. Cheung H. Tak. "Characterization of the adhesion of lymphocytes to extracellular matrix proteins." Normal, Ill. Illinois State University, 1989. http://wwwlib.umi.com/cr/ilstu/fullcit?p8918625.

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Thesis (Ph. D.)--Illinois State University, 1989.<br>Title from title page screen, viewed October 12, 2005. Dissertation Committee: H. Tak Cheung (chair), David W. Borst, Herman E. Brockman, Arlan G. Richardson, Brian J. Wilkinson. Includes bibliographical references (leaves 145-156) and abstract. Also available in print.

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8

Burnier, Julia. "Regulation of site-specific liver metastasis by extracellular matrix proteins." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86657.

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Metastatic disease remains the main cause of death from cancer. Few therapeutic options for patients have demonstrated potential in curing metastatic disease. The molecular mechanisms underlying site-specific metastasis and the factors mediating tumor cell homing remain largely unknown. Based on a murine Lewis lung carcinoma tumour model of site-specific metastasis mediated by the expression of the insulin-like growth factor - I receptor (IGF-IR), we identified ECM components that show particular promise in regulating metastasis to a specific site. Specifically, we identified collagen IVα1

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9

Chan, Cheuk-ming, and 陳卓銘. "Controlled protein release from collagen matrix." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B3955868X.

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10

Xu, Qian Angela. "Matrix proteins gene expression by mesenchymal cells." Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/27663.

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Chondrocytes from articular cartilage (AC) of diarthrodial joints and smooth muscle cells (SMCs) derived from blood vessels are both of mesenchymal origin. In this study, the mRNA expression by these cells of matrix proteoglycan (PG) and collagen was examined in vitro and in vivo. Since the expression of matrix components by mesenchymal cells is influenced by their interaction with growth factors and cytokines, experiments were also undertaken in vitro to determine the effect of transforming growth factor B1 (TGF-B1) and interleukin -1B (IL-1B) on PG and collagen gene expression by these cells

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11

Davies, Huw Alun. "A family of glycoproteins from the petioles of Brassica campestris with potential roles in plant development and stress responses." Thesis, University of East Anglia, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317996.

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12

Matias, Marie Anne Teresa J. "Immunohistochemical localization of extracellular matrix proteins of the periodontium during cementogenesis /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16347.pdf.

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13

Yu, Xuefeng. "Mechanism of osteoclast migration : effect of chemoattractant cytokines, extracellular matrix proteins, and proteinase inhibitors." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287659.

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14

Hunter, Morgan Campbell. "Analysis of the interaction of Hsp90 with the extracellular matrix protein fibronectin (FN)." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1020960.

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Mounting evidence suggests that Hsp90 is present and functionally active in the extracellular space. The biological function of extracellular Hsp90 (eHsp90) remains relatively uncharacterized compared to that of intracellular Hsp90. eHsp90 has been shown to interact with a finite number of extracellular proteins, however, despite the identification of eHsp90 interacting proteins, the function of eHsp90 in these complexes is unknown. Several reports suggest a role for eHsp90α in cell migration and invasion. Reported targets for eHsp90 stimulated cell migration include MMPs, LRP-1, tyrosine kina

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15

Seyfried, Nicholas T. "The structure and function of hyaluronan-binding proteins in extracellular matrix assembly." Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:e1a2cf8f-7ac7-4c5a-bd3f-53d7653e8888.

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The chondroitin sulfate proteoglycan (CSPG) aggrecan forms link protein-stabilised complexes with hyaluronan (HA), via its N-terminal G1-domain, that provide cartilage with its load bearing properties. Similar aggregates (potentially containing new members of the link protein family), in which other CSPGs (i.e., versican, brevican and neurocan) substitute for aggrecan, may contribute to the structural integrity of many other tissues including skin and brain. In this thesis, cartilage link protein (cLP) and the G1-domains of aggrecan (AG1) and versican (VG1) were expressed in Drosophila S2 cell

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16

Taylor, Mary Louise. "Extracellular Matrix Proteins of the Nurse Cell Capsule in Trichinella spiralis Infections." PDXScholar, 1994. https://pdxscholar.library.pdx.edu/open_access_etds/4782.

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The infectious first-stage larvae of the nematode Trichinella spiralis is an intracellular parasite of altered skeletal muscle. Invasion of the muscle cell initiates a series of morphological changes in the host muscle cell which ultimately results in a specialized unit called the nurse cell. The completed nurse cell consists of a collagenous capsule, matrix of altered sarcoplasm, and a circulatory rete. The purpose of this study was to determine the types of collagen present in the nurse cell capsule. Additionally, the presence of the gl ycoproteins, laminin and tenascin was determined. This

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17

Al, Ramadan Saeed Yaseen. "Analysis of some novel uterine extracellular matrix proteins and a growth factor." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1383.

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18

Xia, Ying. "Influence of extracellular matrix proteins on expression of proteinases in endothelial cells /." [S.l.] : [s.n.], 2001. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=14024.

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19

McFarlane, Ainsley Alana Carole. "Structural and functional characterization of the extracellular matrix proteins COMPcc and NtA." Elsevier, 2009. http://hdl.handle.net/1993/4837.

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The extracellular matrix (ECM) is a complex of proteins and carbohydrates that not only provides a structural support between tissues but also functions in a wide variety of cellular activities. ECM proteins are large, complex proteins with many repeating domains. Individual domains can be analyzed for the investigation of structure-function relationships. This thesis focuses on two ECM proteins of interest: N-terminal agrin (NtA) and the coiled-coil domain of cartilage oligomeric matrix protein (COMPcc). Agrin is an important ECM protein involved in postsynaptic differentiation at the neu

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20

Yaka, Cane. "Studies of axonal regeneration on a grid pattern of extracellular matrix proteins." Thesis, Uppsala universitet, Institutionen för neurovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-205230.

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21

Ichikawa, Takafumi. "Roles of vinexin family proteins in sensing the stiffness of extracellular matrix." Kyoto University, 2017. http://hdl.handle.net/2433/225957.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第20587号<br>農博第2239号<br>新制||農||1052(附属図書館)<br>学位論文||H29||N5076(農学部図書室)<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授矢﨑一史, 教授宮川恒<br>学位規則第4条第1項該当

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22

Degendorfer, Georg. "Mechanisms and Biological Consequences of Damage to Extracellular Matrix Proteins by Peroxynitrite." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14554.

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Peroxynitrite (ONOO–) is a potent oxidizing and nitrating agent, formed under inflammatory conditions by the diffusion-controlled reaction of superoxide radicals (O2•–) with nitric oxide (•NO). This species reacts rapidly, via both non-radical and radical reactions, with proteins resulting in protein damage. As there are limited antioxidant and repair enzymes extracellularly, damage to extracellular matrix (ECM) proteins is likely to persist and accumulate over time. However, there is a lack of detailed mechanistic information on how ONOO– oxidation and nitration affects ECM proteins. This The

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23

Leung, Ho-chuen, and 梁浩銓. "A study of H5N1-M2e-based universal influenza vaccine." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208568.

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The ectodomain of influenza matrix protein 2 (M2e) may be an ideal candidate in the development of influenza universal vaccine due to its highly conserved property among different subtypes/strains of influenza virus. M2e based vaccines have been extensively studied and potent cross-subtype/strain protections have been reported. However, more and more M2e mutants of influenza virus have been identified in recent years. It is still unclear whether M2e based vaccines are effective against these M2e mutants of influenza virus. This study first evaluated cross-protection of an M2e tetrameric pepti

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24

Woo, Wei-Meng. "Roles of epidermal cytoskeleton and extracellular matrix proteins in Caenorhabditis elegans embryonic morphogenesis /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2005. http://uclibs.org/PID/11984.

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25

Pohjolainen, V. (Virva). "Characterization of non-collagenous extracellular matrix proteins in cardiac and aortic valve remodelling." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514299025.

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Abstract Heart failure (HF) and aortic valve stenosis (AS) are complex disorders affected by functional alterations and actively regulated remodelling of the heart and the aortic valve, respectively. In addition to structural proteins, such as collagens and elastin, the extracellular matrix (ECM) in the heart and the aortic valve comprises non-collagenous factors that are not strictly involved in the architecture but may modulate cardiac and valvular remodelling. In the present study the expression of non-collagenous fibrosis- and calcification-related ECM proteins was investigated in HF-assoc

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26

Tate, Ciara Caltagirone. "The role of extracellular matrix proteins in traumatic brain injury and cell transplantation." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-05302006-203440/.

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Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2007.<br>Bellamkonda, Ravi, Committee Member ; LaPlaca, Michelle, Committee Chair ; Stein, Donald, Committee Member ; Garca̕, Andrš, Committee Member ; Archer, David, Committee Member ; Borlongan, Cesario, Committee Member.

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27

McVey, Gillian. "The expression, purification and characterisation of hyaluronan-binding domains from extracellular matrix proteins." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270208.

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28

Stone, Louise Catherine. "Regulation of hepatic stellate cell phenotype and cytoglobin expression by extracellular matrix proteins." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5680/.

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All chronic liver diseases can induce fibrosis and lead to liver cirrhosis. Within liver disease, hepatic stellate cells (HSC) are accepted as the major effectors of fibrogenesis and changes in the extracellular matrix (ECM). Cytoglobin (CYGB), a hexacoordinated globin, is upregulated in liver disease, and expression has been reported to be specific to HSCs in the liver, though this is disputed. Data presented in Chapter 3 of this thesis confirm upregulation of Cygb in murine models of liver disease and diseased human liver tissue. Chapter 4 shows how ECM can effect HSC morphology, behaviour a

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29

Ip, Ying-chi. "MT1-MMP in relation to metastasis of hepatocellular carcinoma." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31490189.

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30

Wu, Wing-kei Ricky. "Development of an in vitro assay for MMP cleavage /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31494183.

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31

Thoumine, Olivier. "Effect of steady and pulsatile laminar shear stress on extracellular matrix and focal contact-associated proteins of endothelial cells." Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/17079.

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32

Wu, Wing-kei Ricky, and 胡永基. "Development of an in vitro assay for MMP cleavage." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B4501050X.

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33

Xu, Jinye, and 徐金叶. "Two-photon photochemical crosslinking-based fabrication of protein microstructures." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47179223.

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One of the challenges in tissue engineering is to fabricate scaffolds which can mimic the natural microenvironments of cells. In a cell niche, biophysical and mechanical cues are crucial factors influencing cell functions. Given the complexity of natural extracellular matrix (ECM) engineered ECMs providing controllable biophysical and mechanical cues are appealing both in enhancing the understanding of cell-matrix interaction and in controlling cell fates in vitro. The ultimate goal of our study is to establish a platform as an engineered ECM by fabricating customized solid protein micros

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34

Ma, Jiaoni, and 馬姣妮. "Multiphoton based biofabrication of 3D protein micro-structures and micro-patterns : voxel and cell matrix niche studies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208048.

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35

Brown, Ashley Carson. "Modulation of pulmonary epithelial to mesenchymal transitions through control of extracellular matrix microenvironments." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44827.

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Epithelial to mesenchymal transition (EMT), the transdifferentation of an epithelial cell into a mesenchymal fibroblast, is a cellular process necessary for embryonic development and wound healing. However, uncontrolled EMT can result in accumulation of myofibroblasts and excessive deposition of ECM, contributing to the pathological progression of fibrotic diseases such as pulmonary fibrosis. The ability to control EMT is important for development of novel therapeutics for fibrotic pathologies and for designing novel biomaterials for tissue engineering applications seeking to promote EMT for

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36

McGuire, Vincent Michael. "Assembly and function of the PsB multiprotein complex during spore differentiation in Dictyostelium discoideum /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9737858.

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37

Cardó, i. Vila Marina. "Functional role of extracellular matrix proteins and their receptors in apoptosis and cell survival." Doctoral thesis, Universitat de Barcelona, 2003. http://hdl.handle.net/10803/3009.

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Macrophages require presence of M-CSF to survive and proliferate. Incubation of bone marrow macrophages with soluble factors (LPS or IFN-gamma) or insoluble factors such as extracellular matrix proteins (Decorin, FN) macrophage proliferation was blocked. Moreover, pretreatment of macrophages with IFN-gamma protects from apoptosis induced by several stimuli. Inhibition of p21Waf with antisense oligonucleotides or using null mice showed that the induction of p21Waf by IFN-gamma mediate this protection. Thus, IFN-gamma makes macrophages unresponsive to apoptotic stimuli by inducing p21Waf and

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38

Nievergelt, Alexandra. "Regulation of HT1080 fibrosarcoma cell migration : role of signalling pathways and extracellular matrix proteins /." [S.l.] : [s.n.], 2004. http://www.zb.unibe.ch/download/eldiss/04nievergelt_a.pdf.

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39

Da, Silva Lodge Michelle. "Extracellular matrix associated proteins and processing enzymes as urinary biomarkers of Chronic Kidney Disease." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/11490/.

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Background: Chronic Kidney Disease (CKD) is often progressive leading to End Stage Renal Disease (ESRD). Early detection of progressive CKD would almost certainly improve long term outcome. Current kidney function tests have serious limitations as they only can detect dysfunction after significant damage has occurred, provide limited help with diagnosis and are unhelpful in assessing early response to therapy or long term prognosis. Therefore there is a requirement for identification of early and reliable non invasive biomarkers of kidney disease and its progression. Regardless of the underlyi

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40

Leung, Wai-lun Alan. "Functional analyses of type IIA procollagen in embryo development /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36434188.

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41

Ferron, Florence Joelle. "The implications of fibulin-5 on elastin assembly and its role in the elastic fiber /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101846.

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The extracellular matrix (ECM) is the material found surrounding the cells in a tissue. One component of the ECM is the elastic fiber, which confers the property of elasticity to its environment. Organs such as the lung, skin and major blood vessels have an abundance of elastic fibers so that they are able to expand and recoil. Elastic fibers are composed of two main components; elastin and microfibrils. Microfibrils are composed primarily of fibrillin-1 and provide a scaffold unto which tropoelastin monomers assemble. Elastic fibers interact with many other proteins in the ECM, one of which i

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42

Ip, Ying-chi, and 葉瑩芝. "MT1-MMP in relation to metastasis of hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31490189.

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43

Sun, Wentao, and 孙文韬. "The effects of Panax notoginseng extracts and its components on TNF-alpha induced MMP-9 expression and activity." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207686.

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Matrix metalloproteinase (MMP) induced extra cellular matrix (ECM) degradation is a crucial process involved in the development of many chronic inflammatory diseases, including cardiac remodeling and cancer metastasis. In cardiac remodeling, the presence of pathological stimuli leads to elevated MMP-9 expression and impairment of cardiac performance, which subsequently develops into heart failure. While in tumorgenesis, MMP-9 has been found to play key roles in metastasis, as it can break physical barriers for the tumor. Therefore, searching for agents targeting MMP-9 is a new direction for th

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44

Petersson, Ulrika. "Studies on three matrix molecules in bone and dentin /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-702-9/.

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45

Liao, Zhiming. "Molecular aspects of cardiac cytochrome C oxidase and extracellular matrix proteins in copper-deficient rats /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487853913100837.

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46

Heilshorn, Sarah Christine Tirrell David A. "Design and characterization of artificial extracellular matrix proteins for use as small-diameter vascular grafts /." Diss., Pasadena, Calif. : California Institute of Technology, 2004. http://resolver.caltech.edu/CaltechETD:etd-05242004-103633.

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47

Shelton, Setareh Lillian. "Characterization of mechanisms regulating scleral extracellular matrix remodeling to promote myopia development." Oklahoma City : [s.n.], 2009.

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48

Lavoie, Jean-Michel. "Mammalian cell culture on poly (dimethyl siloxane) functionalized for covalent immobilization of extracellular matrix-derived proteins." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116017.

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In vitro cell culture is an essential part of many cell and tissue engineering approaches. In particular, monolayer culture of mammalian cells is a key tool for applications such as cell therapy. Novel bioreactors like the Cellerator(TM) allow for expansion of cell populations on mechanically stimulated surfaces coated with proteins. This thesis constitutes a preliminary study which focused on cell-matrix interactions in the absence of stretch. The aim was to establish standard protocols for protein coating on poly (dimethyl siloxane) (PDMS) and for measuring cell proliferation. Specifically,

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49

Phillips, Jonathan Adam. "Convergent Biochemical and Biomechanical Pathways in Tissue Remodeling: The Role of α₂β₁ Integrin and MMP Activity: A Dissertation". eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/274.

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The extracellular matrix is a multi-functional environment that cells inhabit to form living tissue. To maintain the tissue, cells require constant telemetry with the matrix and respond to a variety of cues by remodeling matrix architecture. In this study the physical and biochemical manipulation of the matrix by resident cells is explored to better understand how these are used to remodel tissue. Cell-populated collagen hydrogels are used as a controllable in vitro tissue model. To directly measure mechanical forces involved with gel contraction, a culture force monitor wa

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50

Ojaniemi, M. (Marja). "Docking proteins p130^Cas and p120^Cbl in integrin and growth factor receptor signalling." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514253078.

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Abstract Adhesive interactions between cells and extracellular matrix proteins play a vital role in biological processes such as cell proliferation, differentiation and survival. Integrins comprise a major family of cell surface receptors that mediate these interactions. Integrin engagement triggers adhesion-dependent intracellular signalling cascades that include the phosphorylation of tyrosines in intracellular signalling proteins. Integrin-dependent signals act in concert with signals from growth factors and other signalling receptors. The objective of this thesis was to study how c

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