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Journal articles on the topic 'Extracellular microvesicles'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 April 2022

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1

Wurdinger, Thomas, NaTosha N. Gatson, Leonora Balaj, Balveen Kaur, Xandra O. Breakefield, and D. Michiel Pegtel. "Extracellular Vesicles and Their Convergence with Viral Pathways." Advances in Virology 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/767694.

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Extracellular vesicles (microvesicles), such as exosomes and shed microvesicles, contain a variety of molecules including proteins, lipids, and nucleic acids. Microvesicles appear mostly to originate from multivesicular bodies or to bud from the plasma membrane. Here, we review the convergence of microvesicle biogenesis and aspects of viral assembly and release pathways. Herpesviruses and retroviruses, amongst others, recruit several elements from the microvesicle biogenesis pathways for functional virus release. In addition, noninfectious pleiotropic virus-like vesicles can be released, conta

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2

Sedgwick, Alanna E., and Crislyn D'Souza-Schorey. "The biology of extracellular microvesicles." Traffic 19, no. 5 (2018): 319–27. http://dx.doi.org/10.1111/tra.12558.

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3

Lee, Kyungheon, Huilin Shao, Ralph Weissleder, and Hakho Lee. "Acoustic Purification of Extracellular Microvesicles." ACS Nano 9, no. 3 (2015): 2321–27. http://dx.doi.org/10.1021/nn506538f.

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4

Holme, Pål André, Frank Brosstad, and Nils Olav Solum. "The Difference Between Platelet and Plasma FXIII Used to Study the Mechanism of Platelet Microvesicle Formation." Thrombosis and Haemostasis 70, no. 04 (1993): 681–86. http://dx.doi.org/10.1055/s-0038-1649649.

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SummaryThe formation of microvesicles from platelets was induced either by activation of the complement system by a monoclonal antibody to CD9, or by incubation of platelets with the calcium ionophore A23187. A filter technique to isolate the microvesicles without plasma contamination is described. The microvesicles contained FXIIIa2 from the platelet cytoplasm which shows that these particles contain significant amounts of intracellular material. This was shown by the use of crossed immunoelectrophoresis with rabbit antibodies to total human platelet proteins in the second dimension gel and p

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Rogers, Maximillian A., Fabrizio Buffolo, Florian Schlotter, et al. "Annexin A1–dependent tethering promotes extracellular vesicle aggregation revealed with single–extracellular vesicle analysis." Science Advances 6, no. 38 (2020): eabb1244. http://dx.doi.org/10.1126/sciadv.abb1244.

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Extracellular vesicles (EVs) including plasma membrane–derived microvesicles and endosomal-derived exosomes aggregate by unknown mechanisms, forming microcalcifications that promote cardiovascular disease, the leading cause of death worldwide. Here, we show a framework for assessing cell-independent EV mechanisms in disease by suggesting that annexin A1 (ANXA1)–dependent tethering induces EV aggregation and microcalcification. We present single-EV microarray, a method to distinguish microvesicles from exosomes and assess heterogeneity at a single-EV level. Single-EV microarray and proteomics r

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Raposo, Graça, and Willem Stoorvogel. "Extracellular vesicles: Exosomes, microvesicles, and friends." Journal of Cell Biology 200, no. 4 (2013): 373–83. http://dx.doi.org/10.1083/jcb.201211138.

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Cells release into the extracellular environment diverse types of membrane vesicles of endosomal and plasma membrane origin called exosomes and microvesicles, respectively. These extracellular vesicles (EVs) represent an important mode of intercellular communication by serving as vehicles for transfer between cells of membrane and cytosolic proteins, lipids, and RNA. Deficiencies in our knowledge of the molecular mechanisms for EV formation and lack of methods to interfere with the packaging of cargo or with vesicle release, however, still hamper identification of their physiological relevance

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7

Polito, Raffaella, Mattia Musto, Maria Eleonora Temperini, et al. "Infrared Nanospectroscopy of Individual Extracellular Microvesicles." Molecules 26, no. 4 (2021): 887. http://dx.doi.org/10.3390/molecules26040887.

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Extracellular vesicles are membrane-delimited structures, involved in several inter-cellular communication processes, both physiological and pathological, since they deliver complex biological cargo. Extracellular vesicles have been identified as possible biomarkers of several pathological diseases; thus, their characterization is fundamental in order to gain a deep understanding of their function and of the related processes. Traditional approaches for the characterization of the molecular content of the vesicles require a large quantity of sample, thereby providing an average molecular profi

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Pizzirani, Cinzia, Davide Ferrari, Paola Chiozzi та ін. "Stimulation of P2 receptors causes release of IL-1β–loaded microvesicles from human dendritic cells". Blood 109, № 9 (2006): 3856–64. http://dx.doi.org/10.1182/blood-2005-06-031377.

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Abstract Dendritic cells (DCs) are professional antigen-presenting cells that initiate the immune response by activating T lymphocytes. DCs express plasma membrane receptors for extracellular nucleotides named P2 receptors (P2Rs). Stimulation of P2Rs in these cells is known to cause chemotaxis, cytokine release, and cell death and to modulate LPS-dependent differentiation. Here we show that stimulation of the P2X7 receptor subtype (P2X7R) causes fast microvesicle shedding from DC plasma membrane. Vesicle release occurs from both immature and mature DCs; however, only vesicles from mature DCs,

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9

Brewster, L. Madden, Geoff B. Coombs, Vinicius P. Garcia, et al. "Effects of circulating extracellular microvesicles from spinal cord-injured adults on endothelial cell function." Clinical Science 134, no. 7 (2020): 777–89. http://dx.doi.org/10.1042/cs20200047.

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Abstract People with spinal cord injury (SCI) have three- to four-fold greater risk of cardiovascular disease (CVD) compared with those without SCI. Although circulating extracellular microvesicles are key effectors of vascular health and disease, how their functional phenotype might be altered with SCI is unknown. The aim of the present study was to determine the effects of microvesicles isolated from SCI adults on endothelial cell inflammation and oxidative stress as well as endothelial nitric oxide (NO) synthase (eNOS) activation and tissue-type plasminogen activator (t-PA) expression. Eigh

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10

Rzepiel, Andrea, Nóra Kutszegi, Judit Cs. Sági, et al. "Extracelluláris vesiculák és hematológiai malignitásokban játszott szerepük." Orvosi Hetilap 157, no. 35 (2016): 1379–84. http://dx.doi.org/10.1556/650.2016.30532.

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Extracellular vesicles are produced in all organisms. The most intensively investigated categories of extracellular vesicles include apoptotic bodies, microvesicles and exosomes. Among a very wide range of areas, their role has been confirmed in intercellular communication, immune response and angiogenesis (in both physiological and pathological conditions). Their alterations suggest the potential use of them as biomarkers. In this paper the authors give an insight into the research of extracellular vesicles in general, and then focus on published findings in hematological malignancies. Quanti

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11

Brewster, L. Madden, Anthony R. Bain, Vinicius P. Garcia, et al. "Global REACH 2018: dysfunctional extracellular microvesicles in Andean highlander males with excessive erythrocytosis." American Journal of Physiology-Heart and Circulatory Physiology 320, no. 5 (2021): H1851—H1861. http://dx.doi.org/10.1152/ajpheart.00016.2021.

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In this study, we determined the effects of microvesicles isolated from Andean highlanders with excessive erythrocytosis (EE) on endothelial cell inflammation, oxidative stress, apoptosis, and NO production. Microvesicles from highlanders with EE induced a dysfunctional response from endothelial cells characterized by increased cytokine release and expression of active nuclear factor-κB and reduced nitric oxide production. Andean highlanders with EE exhibit dysfunctional circulating extracellular microvesicles that induce a proinflammatory, proatherogenic endothelial phenotype.

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12

Agrahari, Vivek, Vibhuti Agrahari, Pierre-Alain Burnouf, Chee Ho Chew, and Thierry Burnouf. "Extracellular Microvesicles as New Industrial Therapeutic Frontiers." Trends in Biotechnology 37, no. 7 (2019): 707–29. http://dx.doi.org/10.1016/j.tibtech.2018.11.012.

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13

Conde-Vancells, Javier, Esperanza Gonzalez, Shelly C. Lu, Jose M. Mato, and Juan M. Falcon-Perez. "Overview of extracellular microvesicles in drug metabolism." Expert Opinion on Drug Metabolism & Toxicology 6, no. 5 (2010): 543–54. http://dx.doi.org/10.1517/17425251003614766.

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14

Osteikoetxea, Xabier, Barbara Sódar, Andrea Németh, et al. "Differential detergent sensitivity of extracellular vesicle subpopulations." Organic & Biomolecular Chemistry 13, no. 38 (2015): 9775–82. http://dx.doi.org/10.1039/c5ob01451d.

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15

Schwager, Samantha C., Francois Bordeleau, Jian Zhang, Marc A. Antonyak, Richard A. Cerione, and Cynthia A. Reinhart-King. "Matrix stiffness regulates microvesicle-induced fibroblast activation." American Journal of Physiology-Cell Physiology 317, no. 1 (2019): C82—C92. http://dx.doi.org/10.1152/ajpcell.00418.2018.

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Extracellular vesicles released by cancer cells have recently been implicated in the differentiation of stromal cells to their activated, cancer-supporting states. Microvesicles, a subset of extracellular vesicles released from the plasma membrane of cancer cells, contain biologically active cargo, including DNA, mRNA, and miRNA, which are transferred to recipient cells and induce a phenotypic change in behavior. While it is known that microvesicles can alter recipient cell phenotype, little is known about how the physical properties of the tumor microenvironment affect fibroblast response to

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16

Zhang, Linwen, Jeremie Parot, Vincent A. Hackley, and Illarion V. Turko. "Quantitative Proteomic Analysis of Biogenesis-Based Classification for Extracellular Vesicles." Proteomes 8, no. 4 (2020): 33. http://dx.doi.org/10.3390/proteomes8040033.

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Extracellular vesicles (EVs) are traditionally divided into two major groups: (i) large vesicles originating from plasma membrane and called microvesicles, and (ii) small vesicles originating from the endoplasmic membrane and called exosomes. However, it is increasingly clear that the actual composition of a particular EV preparation cannot be adequately described with these two simple terms and is much more complex. Since the cell membrane origin of EVs predetermines their biological functions, the understanding of EV biogenesis is important for accurate interpretation of observed results. In

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17

Inal, Jameel M., Una Fairbrother, and Sheelagh Heugh. "Microvesiculation and Disease." Biochemical Society Transactions 41, no. 1 (2013): 237–40. http://dx.doi.org/10.1042/bst20120258.

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The important roles of extracellular vesicles in the pathogenesis of various diseases are rapidly being elucidated. As important vehicles of intercellular communication, extracellular vesicles, which comprise microvesicles and exosomes, are revealing important roles in cancer tumorigenesis and metastases and in the spread of infectious disease. The September 2012 Focused Meeting ‘Microvesiculation and Disease’ brought together researchers working on extracellular vesicles. The papers in this issue of Biochemical Society Transactions review work in areas including HIV infection, kidney disease,

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18

Sullivan, Robert. "Epididymosomes Role of extracellular microvesicles in sperm maturation." Frontiers in Bioscience 8, no. 1 (2016): 106–14. http://dx.doi.org/10.2741/s450.

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19

Muralidharan-Chari, V., J. W. Clancy, A. Sedgwick, and C. D'Souza-Schorey. "Microvesicles: mediators of extracellular communication during cancer progression." Journal of Cell Science 123, no. 10 (2010): 1603–11. http://dx.doi.org/10.1242/jcs.064386.

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20

Stahl, Philip D., and Graca Raposo. "Extracellular Vesicles: Exosomes and Microvesicles, Integrators of Homeostasis." Physiology 34, no. 3 (2019): 169–77. http://dx.doi.org/10.1152/physiol.00045.2018.

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Extracellular vesicles (EVs), cell-derived membrane structures, are secreted after fusion of endosomes with the plasma membrane (exosomes) or shed from the plasma membrane (microvesicles). EVs play a key role both in physiological balance and homeostasis and in disease processes by their ability to participate in intercellular signaling and communication.

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21

Shlykova, D. S., V. M. Pisarev, A. M. Gaponov, and A. V. Tutelyan. "Interaction of bacterial extracellular microvesicles with eukaryotic cells." Medical Immunology (Russia) 22, no. 6 (2021): 1065–84. http://dx.doi.org/10.15789/1563-0625-iob-2079.

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Bacterial extracellular microvesicles (BMV) are formed by nonpathogenic, pathogenic and opportunistic bacteria. BMV are spherical bilayer-membrane organelles containing different cargoes: lipopolysaccharides, pathogen associated molecular patterns (PUMP), DNA, RNA, signal molecules, proteins, antibiotic resistance factors, virulence factors, toxins providing various immune response options and conducive to the survival and pathogen dissemination in the human body. BMVs secretion play an important role in the ability of microorganisms to cause various diseases. BMV are involved in biofilms form

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22

Puhm, Florian, Taras Afonyushkin, Ulrike Resch, et al. "Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells." Circulation Research 125, no. 1 (2019): 43–52. http://dx.doi.org/10.1161/circresaha.118.314601.

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Rationale: Extracellular vesicles, including microvesicles, are increasingly recognized as important mediators in cardiovascular disease. The cargo and surface proteins they carry are considered to define their biological activity, including their inflammatory properties. Monocyte to endothelial cell signaling is a prerequisite for the propagation of inflammatory responses. However, the contribution of microvesicles in this process is poorly understood. Objective: To elucidate the mechanisms by which microvesicles derived from activated monocytic cells exert inflammatory effects on endothelial

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23

Heijnen, Harry F. G., Anja E. Schiel, Rob Fijnheer, Hans J. Geuze, and Jan J. Sixma. "Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules." Blood 94, no. 11 (1999): 3791–99. http://dx.doi.org/10.1182/blood.v94.11.3791.

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Abstract Platelet activation leads to secretion of granule contents and to the formation of microvesicles by shedding of membranes from the cell surface. Recently, we have described small internal vesicles in multivesicular bodies (MVBs) and -granules, and suggested that these vesicles are secreted during platelet activation, analogous to the secretion of vesicles termed exosomes by other cell types. In the present study we report that two different types of membrane vesicles are released after stimulation of platelets with thrombin receptor agonist peptide SFLLRN (TRAP) or -thrombin: microv

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Heijnen, Harry F. G., Anja E. Schiel, Rob Fijnheer, Hans J. Geuze, and Jan J. Sixma. "Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules." Blood 94, no. 11 (1999): 3791–99. http://dx.doi.org/10.1182/blood.v94.11.3791.423a22_3791_3799.

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Platelet activation leads to secretion of granule contents and to the formation of microvesicles by shedding of membranes from the cell surface. Recently, we have described small internal vesicles in multivesicular bodies (MVBs) and -granules, and suggested that these vesicles are secreted during platelet activation, analogous to the secretion of vesicles termed exosomes by other cell types. In the present study we report that two different types of membrane vesicles are released after stimulation of platelets with thrombin receptor agonist peptide SFLLRN (TRAP) or -thrombin: microvesicles o

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25

Timár, Csaba I., Ákos M. Lőrincz, Roland Csépányi-Kömi, et al. "Antibacterial effect of microvesicles released from human neutrophilic granulocytes." Blood 121, no. 3 (2013): 510–18. http://dx.doi.org/10.1182/blood-2012-05-431114.

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Abstract Cell-derived vesicles represent a recently discovered mechanism for intercellular communication. We investigated their potential role in interaction of microbes with host organisms. We provide evidence that different stimuli induced isolated neutrophilic granulocytes to release microvesicles with different biologic properties. Only opsonized particles initiated the formation of microvesicles that were able to impair bacterial growth. The antibacterial effect of neutrophil-derived microvesicles was independent of production of toxic oxygen metabolites and opsonization or engulfment of

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26

Zhang, Pan, Joo Chuan Yeo, and Chwee Teck Lim. "Advances in Technologies for Purification and Enrichment of Extracellular Vesicles." SLAS TECHNOLOGY: Translating Life Sciences Innovation 24, no. 5 (2019): 477–88. http://dx.doi.org/10.1177/2472630319846877.

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Extracellular vesicles (EVs) are lipid bilayer-bound vesicles secreted by cells. Subtypes of EVs such as microvesicles and exosomes are further categorized mainly by their different biogenesis mechanisms. EVs have been revealed to play an important role in disease diagnosis and intercellular communication. Despite the wide interest in EVs, the technologies for the purification and enrichment of EVs are still in their infancy. The isolation of EVs, especially exosomes, is inherently challenging due to their small size and heterogeneity. In this review, we mainly introduce the advances of techni

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Ratajczak, Mariusz Z., and Janina Ratajczak. "Extracellular microvesicles/exosomes: discovery, disbelief, acceptance, and the future?" Leukemia 34, no. 12 (2020): 3126–35. http://dx.doi.org/10.1038/s41375-020-01041-z.

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AbstractThere are concepts in science that need time to overcome initial disbelief before finally arriving at the moment when they are embraced by the research community. One of these concepts is the biological meaning of the small, spheroidal vesicles released from cells, which are described in the literature as microparticles, microvesicles, or exosomes. In the beginning, this research was difficult, as it was hard to distinguish these small vesicles from cell debris or apoptotic bodies. However, they may represent the first language of cell–cell communication, which existed before a more sp

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Ratajczak, Mariusz Z., and Janina Ratajczak. "Innate Immunity Communicates Using the Language of Extracellular Microvesicles." Stem Cell Reviews and Reports 17, no. 2 (2021): 502–10. http://dx.doi.org/10.1007/s12015-021-10138-6.

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AbstractThe innate immunity system and extracellular microvesicles (ExMVs) both emerged early in the evolution of life, which is why its innate immunity cellular arm and its soluble-component arm learned, understood, and adapted to the “language” of ExMVs. This was most likely the first language of cell–cell communication during evolution, which existed before more specific intercellular crosstalk involving specific ligands and receptors emerged. ExMVs are involved in several processes in the body, including immune and coagulation responses, which are part of inflammation. In this review we wi

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Guan, Fulin, Xiaochao Xiang, Yuping Xie, et al. "Simultaneous metabolomics and proteomics analysis of plasma-derived extracellular vesicles." Analytical Methods 13, no. 16 (2021): 1930–38. http://dx.doi.org/10.1039/d1ay00060h.

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A tandem extraction strategy was established to obtain metabolites and proteins from the same batch of extracellular vesicles (EVs) simultaneously, enabling the multi-omics differential analysis of exosomes and microvesicles from human plasma.

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Sakuma, Yu, Keita Fujii, Jiayan Han, and Ryou-u. Takahashi. "Recent Advances in Liquid Biopsy Based on Circulating Tumor DNA." Journal of Clinical Medicine 8, no. 11 (2019): 1957. http://dx.doi.org/10.3390/jcm8111957.

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31

Ridger, Victoria C., Chantal M. Boulanger, Anne Angelillo-Scherrer, et al. "Microvesicles in vascular homeostasis and diseases." Thrombosis and Haemostasis 117, no. 07 (2017): 1296–316. http://dx.doi.org/10.1160/th16-12-0943.

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SummaryMicrovesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as “microparticles”. There is mounting evidence revealing a role for microvesicles in intercellular communication, with particular relevance to hemostasis and vascular biology. Coupled with this, the potential of microvesicles as meaningful biomarkers is under intense investigation. This Position Paper will summarise the current knowledge on the mechanisms of formation and

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Raimondo, Stefania, Chiara Corrado, Lavinia Raimondi, Giacomo De Leo, and Riccardo Alessandro. "Role of Extracellular Vesicles in Hematological Malignancies." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/821613.

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In recent years the role of tumor microenvironment in the progression of hematological malignancies has been widely recognized. Recent studies have focused on how cancer cells communicate within the microenvironment. Among several factors (cytokines, growth factors, and ECM molecules), a key role has been attributed to extracellular vesicles (EV), released from different cell types. EV (microvesicles and exosomes) may affect stroma remodeling, host cell functions, and tumor angiogenesis by inducing gene expression modulation in target cells, thus promoting cancer progression and metastasis. Mi

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Bano, Reshma, Farhan Ahmad, and Mohd Mohsin. "A perspective on the isolation and characterization of extracellular vesicles from different biofluids." RSC Advances 11, no. 32 (2021): 19598–615. http://dx.doi.org/10.1039/d1ra01576a.

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Battistelli, Michela, and Elisabetta Falcieri. "Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication." Biology 9, no. 1 (2020): 21. http://dx.doi.org/10.3390/biology9010021.

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In the last decade, a new method of cell–cell communication mediated by membranous extracellular vesicles (EVs) has emerged. EVs, including exosomes, microvesicles, and apoptotic bodies (ApoBDs), represent a new and important topic, because they are a means of communication between cells and they can also be involved in removing cellular contents. EVs are characterized by differences in size, origin, and content and different types have different functions. They appear as membranous sacs released by a variety of cells, in different physiological and patho-physiological conditions. Intringuingl

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Ostermeier, Brita, Natalia Soriano-Sarabia, and Sanjay B. Maggirwar. "Platelet-Released Factors: Their Role in Viral Disease and Applications for Extracellular Vesicle (EV) Therapy." International Journal of Molecular Sciences 23, no. 4 (2022): 2321. http://dx.doi.org/10.3390/ijms23042321.

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Platelets, which are small anuclear cell fragments, play important roles in thrombosis and hemostasis, but also actively release factors that can both suppress and induce viral infections. Platelet-released factors include sCD40L, microvesicles (MVs), and alpha granules that have the capacity to exert either pro-inflammatory or anti-inflammatory effects depending on the virus. These factors are prime targets for use in extracellular vesicle (EV)-based therapy due to their ability to reduce viral infections and exert anti-inflammatory effects. While there are some studies regarding platelet mic

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Zhang, Weifei, Pengzhou Huang, Jianjing Lin, and Hui Zeng. "The Role of Extracellular Vesicles in Osteoporosis: A Scoping Review." Membranes 12, no. 3 (2022): 324. http://dx.doi.org/10.3390/membranes12030324.

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As an insidious metabolic bone disease, osteoporosis plagues the world, with high incidence rates. Patients with osteoporosis are prone to falls and becoming disabled, and their cone fractures and hip fractures are very serious, so the diagnosis and treatment of osteoporosis is very urgent. Extracellular vesicles (EVs) are particles secreted from cells to the outside of the cell and they are wrapped in a bilayer of phospholipids. According to the size of the particles, they can be divided into three categories, namely exosomes, microvesicles, and apoptotic bodies. The diameter of exosomes is 3

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Durrieu, Ludovic, Alamelu Bharadwaj, and David M. Waisman. "Analysis of the thrombotic and fibrinolytic activities of tumor cell–derived extracellular vesicles." Blood Advances 2, no. 10 (2018): 1054–65. http://dx.doi.org/10.1182/bloodadvances.2017015479.

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Aires, Inês Dinis, Teresa Ribeiro-Rodrigues, Raquel Boia, et al. "Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading." Biomolecules 11, no. 6 (2021): 770. http://dx.doi.org/10.3390/biom11060770.

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Microglial cells are the neuroimmune competent cells of the central nervous system. In the adult, microglia are responsible for screening the neuronal parenchyma searching for alterations in homeostasis. Chronic neuroinflammation plays a role in neurodegenerative disease. Indeed, microglia-mediated neuroinflammation is involved in the onset and progression of several disorders in the brain and retina. Microglial cell reactivity occurs in an orchestrated manner and propagates across the neural parenchyma spreading the neuroinflammatory signal from cell to cell. Extracellular vesicles are import

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Lee, Byung-Cheon, Ji Woong Yoon, Sang Hyun Park, and Seung Zhoo Yoon. "Toward a Theory of the Primo Vascular System: A Hypothetical Circulatory System at the Subcellular Level." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/961957.

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This paper suggests a theoretical framework for the primo vascular system (PVS), a hypothetical circulatory system, in which extracellular DNA microvesicles interact to form and break down cell structures. Since Bonghan Kim reported the existence of Bonghan ducts and the SNU research team reinvestigated and named it the PVS, there has been series of studies trying to examine its structure and functions. In this paper, we hypothesize that the PVS is the network system in which extracellular DNA microvesicles circulate and interact at the subcellular level, forming and breaking down cell structu

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ZLOTOGORSKI-HURVITZ, A., D. DAYAN, G. CHAUSHU, T. SALO, and M. VERED. "CURCUMIN IS RETAINED IN SALIVA BY COMPLEXES WITH EXTRACELLULAR MICROVESICLES." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 124, no. 3 (2017): e217. http://dx.doi.org/10.1016/j.oooo.2017.06.064.

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41

Wang, Danqi, and Wei Sun. "Urinary extracellular microvesicles: Isolation methods and prospects for urinary proteome." PROTEOMICS 14, no. 16 (2014): 1922–32. http://dx.doi.org/10.1002/pmic.201300371.

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Camussi, Giovanni. "Stem Cell Reviews and Reports: Microenvironment and Extracellular Microvesicles Section." Stem Cell Reviews and Reports 13, no. 1 (2017): 4. http://dx.doi.org/10.1007/s12015-017-9725-5.

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Crews, Fulton T., Jian Zou, and Leon G. Coleman. "Extracellular microvesicles promote microglia‐mediated pro‐inflammatory responses to ethanol." Journal of Neuroscience Research 99, no. 8 (2021): 1940–56. http://dx.doi.org/10.1002/jnr.24813.

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Petersen, Jennifer D., Elena Mekhedov, Sukhbir Kaur, David D. Roberts, and Joshua Zimmerberg. "Endothelial cells release hybrid extracellular vesicles: microvesicles that secrete exosomes." Biophysical Journal 121, no. 3 (2022): 293a. http://dx.doi.org/10.1016/j.bpj.2021.11.1285.

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Vásquez, Ximena, Pilar Sánchez-Gómez, and Verónica Palma. "Netrin-1 in Glioblastoma Neovascularization: The New Partner in Crime?" International Journal of Molecular Sciences 22, no. 15 (2021): 8248. http://dx.doi.org/10.3390/ijms22158248.

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Glioblastoma (GBM) is the most aggressive and common primary tumor of the central nervous system. It is characterized by having an infiltrating growth and by the presence of an excessive and aberrant vasculature. Some of the mechanisms that promote this neovascularization are angiogenesis and the transdifferentiation of tumor cells into endothelial cells or pericytes. In all these processes, the release of extracellular microvesicles by tumor cells plays an important role. Tumor cell-derived extracellular microvesicles contain pro-angiogenic molecules such as VEGF, which promote the formation

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Tominaga, Naoomi. "Anti-Cancer Role and Therapeutic Potential of Extracellular Vesicles." Cancers 13, no. 24 (2021): 6303. http://dx.doi.org/10.3390/cancers13246303.

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Cell–cell communication is an important mechanism in biological processes. Extracellular vesicles (EVs), also referred to as exosomes, microvesicles, and prostasomes, are microvesicles secreted by a variety of cells. EVs are nanometer-scale vesicles composed of a lipid bilayer and contain biological functional molecules, such as microRNAs (miRNAs), mRNAs, and proteins. In this review, “EVs” is used as a comprehensive term for vesicles that are secreted from cells. EV research has been developing over the last four decades. Many studies have suggested that EVs play a crucial role in cell–cell c

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Chiriacò, Maria, Monica Bianco, Annamaria Nigro, et al. "Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization." Sensors 18, no. 10 (2018): 3175. http://dx.doi.org/10.3390/s18103175.

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Interest in extracellular vesicles and in particular microvesicles and exosomes, which are constitutively produced by cells, is on the rise for their huge potential as biomarkers in a high number of disorders and pathologies as they are considered as carriers of information among cells, as well as being responsible for the spreading of diseases. Current methods of analysis of microvesicles and exosomes do not fulfill the requirements for their in-depth investigation and the complete exploitation of their diagnostic and prognostic value. Lab-on-chip methods have the potential and capabilities t

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Cole, Eric S., Thomas H. Giddings, Courtney Ozzello, et al. "Membrane Dynamics at the Nuclear Exchange Junction during Early Mating (One to Four Hours) in the Ciliate Tetrahymena thermophila." Eukaryotic Cell 14, no. 2 (2014): 116–27. http://dx.doi.org/10.1128/ec.00164-14.

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ABSTRACT Using serial-section transmission electron microscopy and three-dimensional (3D) electron tomography, we characterized membrane dynamics that accompany the construction of a nuclear exchange junction between mating cells in the ciliate Tetrahymena thermophila . Our methods revealed a number of previously unknown features. (i) Membrane fusion is initiated by the extension of hundreds of 50-nm-diameter protrusions from the plasma membrane. These protrusions extend from both mating cells across the intercellular space to fuse with membrane of the mating partner. (ii) During this process,

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Deolindo, Poliana, Ingrid Evans-Osses, and Marcel Ivan Ramirez. "Microvesicles and exosomes as vehicles between protozoan and host cell communication." Biochemical Society Transactions 41, no. 1 (2013): 252–57. http://dx.doi.org/10.1042/bst20120217.

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Cells release extracellular vesicles in response to external factors or in a physiological way. Microvesicles and exosomes originate in cells in different ways and, depending on their contents, may have multiple biological effects on other cells and the environment. The host cell–parasite relationship could be changed dramatically by the plasticity of a new type of communication through extracellular vesicles. In the present paper, we discuss how protozoans use this new resource to evade the immune system and establish infection.

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Saheera, Sherin, Vivek P. Jani, Kenneth W. Witwer, and Shelby Kutty. "Extracellular vesicle interplay in cardiovascular pathophysiology." American Journal of Physiology-Heart and Circulatory Physiology 320, no. 5 (2021): H1749—H1761. http://dx.doi.org/10.1152/ajpheart.00925.2020.

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Extracellular vesicles (EVs) are nanosized lipid bilayer-delimited particles released from cells that mediate intercellular communications and play a pivotal role in various physiological and pathological processes. Subtypes of EVs may include plasma membrane ectosomes or microvesicles and endosomal origin exosomes, although functional distinctions remain unclear. EVs carry cargo proteins, nucleic acids (RNA and DNA), lipids, and metabolites. By presenting or transferring this cargo to recipient cells, EVs can trigger cellular responses. We summarize contemporary understanding of EV biogenesis

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