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Journal articles on the topic 'Extracorporeal blood purification method'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Marukhov, Artem V., Elena V. Murzina, Mikhail V. Zakharov, et al. "Evaluation of plasma levels of meropenem in septic patients during extracorporeal blood purification." Medical academic journal 20, no. 4 (2021): 81–94. http://dx.doi.org/10.17816/maj54636.

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The relevance. Meropenem is a broad-spectrum carbapenem antibiotic widely used to treat patients with sepsis / septic shock. Critically ill patients are usually supported with one of the forms extracorporeal blood purification. However, data on the effect of various extracorporeal support techniques on the pharmacokinetics and pharmacodynamics of meropenem are insufficient or contradictory. Aim: To evaluate the effectiveness of meropenem dosage regimens in the treatment of septic patients during extracorporeal blood purification. Materials and methods. Plasma concentrations of mero

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Kamilovich, Nasimov Javokhir, Shomuradova Nasiba Khamdamovna, and Madasheva Anajan Gazkhanovna. "Efficiency of Extracorporeal Blood Purification in Food Allergies." International Journal for Research in Applied Science and Engineering Technology 13, no. 5 (2025): 982–85. https://doi.org/10.22214/ijraset.2025.70473.

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Abstract: Food allergies can result in persistent and systemic hypersensitivity reactions that are often resistant to standard treatment methods. This study aimed to assess the clinical and immunological effectiveness of extracorporeal blood purification (EBP) in patients with refractory food allergies. A total of 42 patients with confirmed food allergies underwent three sessions of EBP using plasmapheresis and hemosorption. Significant reductions were observed in symptom severity, total serum IgE, eosinophil counts, histamine, and C-reactive protein levels. Quality of life improved notably as

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Yaroustovsky, M. B., M. V. Abramyan, N. P. Krotenko, and E. V. Komardina. "Methods of Molecular Transfusion in the Intensive Therapy of Critical States." Annals of the Russian academy of medical sciences 71, no. 4 (2016): 281–87. http://dx.doi.org/10.15690/vramn680.

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Development of extracorporeal blood purification acquires greater significance in the intensive care of multiple organ failures (MOF) with all the pathophysiological aspects of its constituent parts. MOF are the main cause of mortality among critically ill patients and treatment of these patients require significant investment. The purpose of the implementation of extracorporeal blood correction techniques today is multiple organ support therapy (MOST). Early extracorporeal therapy is used only in the treatment of renal failure. Today extracorporeal techniques are increasingly being used to re

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Harm, Stephan, Anna Gruber, Franz Gabor, and Jens Hartmann. "Adsorption of Selected Antibiotics to Resins in Extracorporeal Blood Purification." Blood Purification 41, no. 1-3 (2015): 55–63. http://dx.doi.org/10.1159/000440973.

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Background/Aims: Extracorporeal blood purification systems (EBS) use specific adsorbents for the elimination of toxins and cytokines. The aim of this study was to test different adsorbents for their ability to reduce antibiotics in parallel to extracorporeal blood purification therapy. Methods: The in vitro adsorption experiments were carried out in human plasma with a newly established hydrophobic resin (Amberchrom CG161c) and adsorbents commercially available and approved in the clinics. The concentration of antibiotic was chosen equivalent to the recommended therapeutic dosage applied intra

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Sarana, Andrey M., Sergey G. Shcherbak, Dmitry A. Vologzhanin, Aleksandr S. Golota, Tatyana A. Kamilova, and Stanislav V. Makarenko. "Efferent methods of therapy for critical illness." Physical and rehabilitation medicine, medical rehabilitation 6, no. 1 (2024): 49–72. http://dx.doi.org/10.36425/rehab626652.

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Extracorporeal blood purification is intended to eliminate dysregulation of the immune system. The concept of extracorporeal therapy is based on the nonspecific clearance of inflammatory mediators and triggers, which attenuates the systemic expression of inflammatory mediators. The main types of extracorporeal therapy are hemoadsorption and plasma exchange. Hemoadsorption is used primarily as an adjuvant treatment for septic shock and other severe inflammatory conditions, including severe forms of COVID-19 with cytokine storm. Reliable data demonstrating the benefit of hemoadsorption in

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Babaev, Mаxim A., A. S. Tukhtamanova, and A. I. Masneva. "New directions of scientific research and clinical practice in the field of extracorporeal hemocorrection in patients with multiple organ dysfunction: a review." Annals of Critical Care, no. 1 (January 27, 2024): 135–47. http://dx.doi.org/10.21320/1818-474x-2024-1-135-147.

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INTRODUCTION: Due to the COVID-19 (infectious disease caused by the SARS-CoV-2 virus) pandemic, we had to take a completely different approach to the nature of critical conditions. The pandemic also made us reconsider many views about it. Moreover, that contributed to the development of new practical approaches for treatment and prevention, including the ones in the field of extracorporeal hemocorrection. OBJECTIVE: Methods for purification of blood and plasma began to be considered as an independent link for the treatment of organ disorders or as a part of extracorporeal support for the life

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Kovzel, V. A., L. A. Davydova, A. V. Karzin, et al. "Methods of Extracorporeal Hemocorrection in Sepsis (Review)." General Reanimatology 19, no. 2 (2023): 68–82. http://dx.doi.org/10.15360/1813-9779-2023-2-2282.

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Sepsis and septic shock remain a major problem in critical care medicine being the most common causes of death in the intensive care unit. Currently, such methods of extracorporeal blood purification as hemodiafiltration, high-volume hemofiltration, high cut-off (HCO) membrane hemofiltration are among preferable options for treatment of severe systemic disorders and pathological conditions including sepsis.The purpose of the review is to show the potentialities and prospects of the use of various extracorporeal hemocorrection methods, including those that are commonly employed in medical pract

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8

Ryazanova, Diana, Zaure Tobylbayeva, Olga Mironova, Erken Kakenov, and Vitaliy Sazonov. "Comparison of CytoSorb and Jafron HA330 Hemoadsorption Devices in Pediatric Oncological Patients with Sepsis: Retrospective Observational Study." Journal of Clinical Medicine 13, no. 24 (2024): 7694. https://doi.org/10.3390/jcm13247694.

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Background: Pediatric sepsis presents a severe risk to immunocompromised children, especially those with cancer or pre-existing conditions, posing a significant threat to their lives. Cytokine hemadsorption has emerged as a promising therapeutic approach for managing sepsis and severe inflammatory conditions in critically ill patients. This innovative method involves eliminating pro-inflammatory cytokines from the bloodstream, targeting the underlying hyper-inflammatory response often seen in critical illnesses. Study aim: The study aim is to examine and compare the efficacy of HA330 and CytoS

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9

Jarczak, Dominik, Stefan Kluge, and Axel Nierhaus. "Septic Hyperinflammation—Is There a Role for Extracorporeal Blood Purification Techniques?" International Journal of Molecular Sciences 25, no. 6 (2024): 3120. http://dx.doi.org/10.3390/ijms25063120.

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This manuscript investigates the role of extracorporeal blood purification techniques in managing septic hyperinflammation, a critical aspect of sepsis characterized by an uncontrolled immune response leading to multiorgan dysfunction. We provide an overview of sepsis, focusing on the dynamics of immune response, the involvement of neutrophils, and the role of the endothelium in the disease’s progression. It evaluates the effectiveness of various blood purification methods, including high-cut-off membranes, high-volume hemofiltration, adsorption techniques, and albumin dialysis, in removing cy

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Pieri, Marina, Matteo A. Bonizzoni, Alessandro Belletti, et al. "Extracorporeal Blood Purification with CytoSorb in 359 Critically Ill Patients." Blood Purification 52, no. 9-10 (2023): 759–67. http://dx.doi.org/10.1159/000530872.

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Introduction: Critically ill patients with inflammatory dysregulation and organ disfunction may benefit from blood purification, although the use of this technique has not been described in large case series. We evaluated clinical outcomes and survival in high-risk intensive care unit (ICU) patients who underwent extracorporeal blood purification. Methods: 359 consecutive ICU patients treated with CytoSorb were included. Results: Main admission diagnoses were 120 (34%) refractory cardiac arrest under mechanical chest compression; 101 (28%) profound cardiogenic shock; 81 (23%) post-cardiotomy c

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Harm, Stephan, Claudia Schildböck, and Jens Hartmann. "Cytokine Removal in Extracorporeal Blood Purification: An in vitro Study." Blood Purification 49, no. 1-2 (2019): 33–43. http://dx.doi.org/10.1159/000502680.

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Background/Aims: Cytokines are among the main target substances that have to be removed effectively in order to improve the patient’s health status in the treatment of sepsis, septic shock, and liver diseases. Although there are various medical devices commercially available, the success of their clinical use is limited. The aim of this in vitro study was to compare 3 different medical devices with respect to their clearance for the cytokines interleukin-6 (IL-6), IL-8, IL-1β, and tumor necrosis factor alpha. The medical devices that were tested are the whole blood adsorbent CytoSorb, the high

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Mendibaev, M. S., and S. E. Rabotinsky. "Pharmacological methods for blood stabilization in the extracorporeal circuit (review of literature)." Messenger of ANESTHESIOLOGY AND RESUSCITATION 20, no. 1 (2023): 81–88. http://dx.doi.org/10.24884/2078-5658-2023-20-1-81-88.

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We summarize the possible benefits and risks of using various anticoagulants during hemoperfusion. Clotting in the extracorporeal circuit can lead to a decrease in the effectiveness of therapy, additional workload, risk to the patient and economic losses. At the same time, relatively excessive anticoagulation against the background of existing hemostasis disorders can lead to severe hemorrhagic complications, which in turn worsen the prognosis of patients. The article describes the causes of heparin resistance, the main techniques for overcoming it, and provides practical guidelines for antico

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Bellomo, R., P. Honoré, J. Matson, C. Ronco, and J. Winchester. "Extracorporeal Blood Treatment (EBT) Methods in SIRS/Sepsis." International Journal of Artificial Organs 28, no. 5 (2005): 450–58. http://dx.doi.org/10.1177/039139880502800505.

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Background Extracorporeal blood purification treatment (EBT) methods have been used in the treatment of experimental and human SIRS/Sepsis in a variety of settings and with variable reports of efficacy and safety. Their role in the management of SIRS/Sepsis remains controversial. Objectives To develop consensus statements regarding important aspects of research, practice and technical management concerning EBT. Methods Systematic review of published study. Evidence-based grading of information available. Consensus development regarding fundamental questions about EBT. Results Consensus was ach

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Serhiyenka, U. K., R. E. Yakubtsevich, and V. A. Kazhina. "INNOVATIVE TECHNOLOGIES IN INTENSIVE CARE OF SEPSIS IN CHILDREN." Journal of the Grodno State Medical University 20, no. 4 (2022): 365–73. http://dx.doi.org/10.25298/2221-8785-2022-20-4-365-373.

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Sepsis in children is still accompanied by high mortality, especially in developing countries, and the annual cost of treatment amounts to billions of dollars. Currently, various methods and combinations of extracorporeal blood purification depending on the characteristics of the clinical course of sepsis, its type and severity are being actively and successfully developed and put into practice. However, not all methods of extracorporeal hemocorrection in children and adults with regard to a particular critical situation have been fully studied. This literature review provides up-to-date data

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Basel, Anthony P., Jason Thomas, Alicia M. Williams, et al. "709 Reconfiguration: Extracorporeal blood purification of a burn patient on ECMO." Journal of Burn Care & Research 43, Supplement_1 (2022): S160. http://dx.doi.org/10.1093/jbcr/irac012.263.

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Abstract Introduction Patients who require extracorporeal membrane oxygenation (ECMO) have a very high mortality if they develop septic shock. Extracorporeal blood purification has been studied as an adjunct to antimicrobials but has yielded mixed or even disappointing results. The Seraph-100 Microbind Affinity Blood Filter (ExThera Medical Corporation, Martinez, CA) is currently undergoing clinical trials. The filter consists of polyethylene beads, coated in heparin sulfate, that irreversibly binds bacteria, fungi, viruses, and toxins. Seraph-100 therapy is traditionally delivered through con

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Maričić, Lana, Damir Mihić, Tajana Turk, Domagoj Loinjak, and Vedran Zubčić. "The Role of Extracorporeal Blood Purification in the Treatment of a Patient with Lemierre's Syndrome." Case Reports in Medicine 2022 (May 28, 2022): 1–3. http://dx.doi.org/10.1155/2022/8522398.

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Lemierre's syndrome refers to the septic thrombophlebitis of the internal jugular vein. The condition typically begins with an oropharyngeal infection and frequently involves inflammation within the wall of the vein, infected thrombus within the lumen, surrounding soft tissue inflammation, persistent bacteremia, and septic emboli. Lemierre's syndrome is a rare disease; it occurs most commonly in otherwise healthy young adults. The most common etiologic agent is Fusobacterium necrophorum. We present a case of Lemierre's syndrome in a young girl and the role of extracorporeal method of blood pur

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Mikhalovsky, Sergey V. "Emerging technologies in extracorporeal treatment: focus on adsorption." Perfusion 18, no. 1_suppl (2003): 47–54. http://dx.doi.org/10.1191/0267659103pf627oa.

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As an extracorporeal technique for blood purification, haemoadsorption was introduced in the early 1960s along with other physico-chemical methods. The problem of poor biocompatibility of uncoated adsorbents was resolved by coating adsorbent granules with haemocompatible membranes. Use of coated adsorbents instead of uncoated ones reduces the efficiency of haemoperfusion. As a result, for many years the use of adsorption was limited to only acute poisoning. Since the 1990s interest in the use of adsorbents in extracorporeal medical devices has been rising again. In this paper some recent devel

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Yakubtsevich, R. E. "BLOCKADE OF THE CYTOKINE STORM IN SEVERE SARS-COV-2 INFECTION: DRUG SUPPRESSION OR EXTRACORPOREAL ELIMINATION?" Journal of the Grodno State Medical University 18, no. 5 (2020): 505–12. http://dx.doi.org/10.25298/2221-8785-2020-18-5-505-512.

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Background: The urgency of the treatment of severe COVID-19 is due to high mortality rate both in general patient population (6.4%) and in patients in intensive care units (25.8%). The cytokine storm is a pathological condition leading to high mortality. There are 2 approaches to reducing inflammatory cytokines in blood: blocking their production by drugs and extracorporeal removal. However, the choice is rather challenging.Purpose: A literature analysis was carried out to study modern approaches to prescribing medications and using extracorporeal detoxification for the blockade of the cytokin

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Yaroustovsky, M. B., M. V. Abramyan, and E. V. Komardina. "Methods of Molecular Transfusion in Intensive Care of Critical States in Pediatric Postoperative Cardiac Surgery Patients." Annals of the Russian academy of medical sciences 71, no. 5 (2016): 341–49. http://dx.doi.org/10.15690/vramn709.

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Molecular techniques in transfusion medicine have become popular in the clinical practice of pediatric intensive care units when the patient needs blood purification, more recently, in children in critical condition. Considering the anatomical and physiological characteristics of the child’s body, pronounced severity, and rapid progression of multiple organ disorders, the key problems defining the treatment results are instrument reading, choice and timely initiation of extracorporeal therapy. Today, along with the methods of renal replacement therapy in children albumin dialysis therapy and h

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Lane, Sophie F., Elizabeth Harvey-Jones, Olivia Ward, and Roger Davies. "Renal replacement and extracorporeal therapies in critical care: current and future directions." Acute Medicine Journal 22, no. 3 (2023): 154–62. http://dx.doi.org/10.52964/amja.0951.

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There are a wide number of indications for extracorporeal therapies in the critical care environment. A common indication seen by the acute physician is continuous renal replacement therapy (CRRT) in a proportion of patients with acute kidney injury. It is therefore important that acute physicians have a sound understanding of the principles of CRRT in the acutely unwell patient. This review will outline the indications for its use, commonly used methods and anticoagulation considerations. It will discuss when to start and stop CRRT as well as describing potential treatment complications. This

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Bakhshivand, Mohammad, Farid Ghorbaninezhad, Somaye Mirzayi, et al. "Hemoperfusion Therapy’s Efficiency in Reducing Serum IL-6 Levels and Disease Severity in COVID-19 Patients." ImmunoAnalysis 2 (December 26, 2022): 10. http://dx.doi.org/10.34172/ia.2022.10.

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Background: Interleukin (IL)-6, one of the inflammatory mediators involved in severe cases of coronavirus disease-19 (COVID-19), has been implicated in the pathogenesis of this disease. Extracorporeal blood purification has been suggested as one of the therapeutic strategies for COVID-19 patients, due to its favorable effect on the removal of inflammatory cytokines. Here, we investigated the impact of hemoperfusion (HP), a type of extracorporeal blood purification, in serum IL-6 levels and disease severity in COVID-19 patients. Methods: 35 patients with severe COVID-19 were enrolled in this st

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Xu, Xuefeng, Huaping Dai, Chun'e Jia, and Chen Wang. "Extracorporeal blood therapy in sepsis and acute respiratory distress syndrome: the “purifying dream”." Chinese Medical Journal 127, no. 24 (2014): 4263–70. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20141869.

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Objective To discuss the rationale, hypothesis, modality of extracorporeal blood purification (EBP) techniques for the critically ill animal models or patients, and to summarize the experimental and clinical studies with inconsistent data which explored the EBP's efficacy in the areas of critical care medicine. Data sources Articles referred in this review were collected from the database of PubMed published in English up to June 2014. Study selection We had done a literature search by using the term “(sepsis OR acute lung injury OR acute respiratory distress syndrome) AND (extracorporeal bloo

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Yakubtsevich, R. E., N. V. Belyavsky, A. A. Glazev, and S. D. Klisa. "Dynamics of essential amino acids plasma levels in patients with sepsis treated by the extracorporeal blood purification methods." Proceedings of the National Academy of Sciences of Belarus, Medical series 17, no. 1 (2020): 64–69. http://dx.doi.org/10.29235/1814-6023-2020-17-1-64-69.

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Extracorporeal blood purification (EBP) is one of the trends of effective sepsis therapy. Some disadvantages of this method such as a possible reduction of plasma levels of different important metabolites are described. It is known that sepsis disorders of amino acid metabolism are manifested in microcirculation interruptions, the decreased immune response and the increased mortality. The aim of the study is to investigate the EBP effect on the essential amino acid plasma levels in patients diagnosed with sepsis. We selected 38 patients diagnosed with sepsis. Standard treatment protocols of pl

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Lorenzin, Anna, Mauro Neri, Massimo de Cal, et al. "Fluid Dynamics Analysis by CT Imaging Technique of New Sorbent Cartridges for Extracorporeal Therapies." Blood Purification 48, no. 1 (2019): 18–24. http://dx.doi.org/10.1159/000499076.

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Background: Recent innovations in biomaterials technology have led to the development of innovative sorbents adopted as adsorbing devices in the field of extracorporeal blood purification therapies. As removal mechanism, adsorption allows to remove specific molecules, selectively binding them to sorbent materials. In addition to the material properties, a quintessential aspect influencing device properties is blood flow distribution within the sorbent particles. Objectives: In order to adequately characterize the potential adsorbing properties for an effective blood purification therapy, an in

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Якубцевич, Р. Э. "The Modern of Aspects of the Use of Therapeutic Plasmapheresis in Intensive Care." Гематология. Трансфузиология. Восточная Европа 10, no. 1 (2024): 79–97. http://dx.doi.org/10.34883/pi.2024.10.1.021.

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Эффективное лечение пациентов отделений интенсивной терапии тесно связано с необходимостью экстракорпорального очищения крови. Одной из таких методик является плазмаферез. Среди большого выбора его разновидностей (центрифужный плазмаферез, плазмофильтрация, каскадный плазмаферез и другие) сегодня непросто разобраться и принять решение в сложной ситуации о правильном назначении того или иного метода детоксикации, определиться с показаниями, основанными на доказательной медицине, и прогнозировать негативные последствия от очищения крови. В представленной лекции изложены современные подходы к пок

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Wójtowicz, Dominika, and Ewa Stodolak-Zych. "Strategies to Mitigate Biofouling of Nanocomposite Polymer-Based Membranes in Contact with Blood." Membranes 13, no. 9 (2023): 762. http://dx.doi.org/10.3390/membranes13090762.

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An extracorporeal blood purification method called continuous renal replacement therapy uses a porous hollow-fiber polymeric membrane that is exposed to prolonged contact with blood. In that condition, like with any other submerged filtration membrane, the hemofilter loses its properties over time and use resulting in a rapid decline in flux. The most significant reason for this loss is the formation of a biofilm. Protein, blood cells and bacterial cells attach to the membrane surface in complex and fluctuating processes. Anticoagulation allows for longer patency of vascular access and a longe

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Mecca, Tommaso, Fabiola Spitaleri, Rita La Spina, Sabrina Gioria, Valentina Giglio, and Francesca Cunsolo. "HEMA-Lysine-Based Cryogels for Highly Selective Heparin Neutralization." International Journal of Molecular Sciences 25, no. 12 (2024): 6503. http://dx.doi.org/10.3390/ijms25126503.

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Unfractionated heparin (UFH) and its low-molecular-weight fragments (LMWH) are widely used as anticoagulants for surgical procedures and extracorporeal blood purification therapies such as cardiovascular surgery and dialysis. The anticoagulant effect of heparin is essential for the optimal execution of extracorporeal blood circulation. However, at the end of these procedures, to avoid the risk of bleeding, it is necessary to neutralize it. Currently, the only antidote for heparin neutralization is protamine sulphate, a highly basic protein which constitutes a further source of serious side eve

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Fausto Bruno, Campana, and Atti Mauro. "Efficiency, Effectiveness and Clinical Results of Extracorporeal Therapies in Non-Renal Settings: How are they to be evaluated? The Case of their Application in Liver Failure." Journal of Clinical Nephrology 8, no. 1 (2024): 008–16. http://dx.doi.org/10.29328/journal.jcn.1001120.

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There are various Extra Blood Purification Therapies (EBPTs) used in the context of critical care, including but not limited to Acute Kidney Injury (AKI). These therapies aim to remove toxins, inflammatory mediators, and excess fluids from the bloodstream. While some blood purification therapies were initially developed for renal support, they have been explored for use in other medical conditions as well, including liver pathologies and sepsis. Here is a brief explanation of some therapies such as MARS (Molecular Adsorbents Recirculating System), Prometheus, CPFA (Coupled Plasma Filtration Ad

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Putzu, Alessandro, Raoul Schorer, Juan Carlos Lopez-Delgado, Tiziano Cassina, and Giovanni Landoni. "Blood Purification and Mortality in Sepsis and Septic Shock." Anesthesiology 131, no. 3 (2019): 580–93. http://dx.doi.org/10.1097/aln.0000000000002820.

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Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Sepsis and septic shock are severe inflammatory conditions related to high morbidity and mortality. We performed a systematic review with meta-analysis of randomized trials to assess whether extracorporeal blood purification reduces mortality in this setting. Methods Electronic databases were searched for pertinent studies up to January 2019. We included randomized controlled trials on the use of hemoperfusion, hemofiltration without a renal replacement purpose, and plasmaphere

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Belinin, G. Ju, V. I. Vasiliev, E. E. Efremov та ін. "Аpplication of plasma proteins cryoheparinoprecipitation method in the treatment of patients with cryoglobulinemia". Meditsinskiy sovet = Medical Council, № 11 (8 серпня 2020): 210–18. http://dx.doi.org/10.21518/2079-701x-2020-11-210-218.

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Introduction. The term “cryoglobulinemia” is currently used to identify immunoglobulins in vitro in the blood serum that precipitate at temperatures below 37 °C; in vivo they form immune complexes that can be deposited in small vessels and activate the complement system with the development of leukocytoclastic vasculitis. Cryoglobulinemia may develop in various lymphoproliferative, autoimmune and infectious diseases. Aim of study. To develop the technique of plasma proteins cryofraction (selective plasmapheresis with the use of heparin as a stimulant of fibronectin opsonic activity and purifie

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Vasiliev, S. A., L. A. Gorgidze, E. E. Efremov, et al. "Fibronectin: structure, functions, clinical significance (review)." Aterotromboz = Atherothrombosis 12, no. 1 (2022): 138–58. http://dx.doi.org/10.21518/2307-1109-2022-12-1-138-158.

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Plasma fibronectin is a high molecular weight adhesive glycoprotein. There are two types of fibronectin: plasma (soluble) and cellular derived (insoluble). Electron microscopy revealed two types of structural organization of fibronectin: compact and expanded. In solution, fibronectin has a compact conformation, and after binding to certain substrates (collagen, fibrin, heparin), it is expanded. Plasma fibronectin is one of the main opsonins of blood plasma in relation to the “targets” of phagocytosis of a predominantly non-bacterial nature, as well as to some types of bacteria. For the treatme

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Peng, Xiaobei, Xingmin Xie, Jun Yin, Saihong Yu, Chunyan Zhang, and Shuangping Zhao. "Anticoagulation Effect and Safety Observation of Regional Citrate Anticoagulation for Double-Filtration Plasmapheresis in Critical Patients." Blood Purification 49, no. 5 (2020): 542–49. http://dx.doi.org/10.1159/000505613.

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Introduction: Double-filtration plasmapheresis (DFPP) is a semi-selective blood purification method based on dual filtration system. Regional citrate anticoagulation (RCA) is an appealing anticoagulation alternative in DFPP. However, there are still few reports on the safety of RCA in DFPP treatment. Objective: To investigate the anticoagulation effect and safety of RCA for DFPP in critical patients. Methods: A total of 34 critical patients treated with DFPP were retrospectively studied. The incidence of coagulation during extracorporeal circulation after single treatment was compared before a

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Mondal, Mithun Kumar, Nur Takia, Abdullah Al Mukit, and Masudul Alam Mazumder. "A rare case of hepatitis a virus-induced acute liver failure managed by hemoadsorption CytoSorb and Biosky MG 350." International Journal of Research in Medical Sciences 13, no. 5 (2025): 2131–34. https://doi.org/10.18203/2320-6012.ijrms20251321.

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Acute liver failure (ALF) is a severe and life-threatening condition characterized by rapid hepatic dysfunction, leading to multi-organ failure and a high mortality rate. It is primarily driven by a profound inflammatory response that exacerbates liver damage and affects systemic organ function. The pathophysiology of ALF involves an imbalance between pro-inflammatory and anti-inflammatory cytokines, which further impairs liver function and worsens clinical outcomes. One promising therapeutic intervention for managing ALF is hemoadsorption, an extracorporeal blood purification technique that h

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Yang, Ke, Honghao Huang, Ruiwu Dai, et al. "Efficacy of Hemoperfusion Cartridge Procedure on Patients Undergoing Cardiac Valve Replacement Surgery with Cardiopulmonary Bypass." Heart Surgery Forum 26, no. 1 (2023): E020—E026. http://dx.doi.org/10.1532/hsf.5213.

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Objectives: Cardiopulmonary bypass (CPB) induces inflammatory homeostasis dysregulation, closely related to many postoperative adverse effects. Minimizing the systemic inflammatory response to CPB is imperative to improving cardiac surgery safety. This study aimed to retrospectively evaluate the efficacy of the hemoperfusion cartridge, a device recently designed for extracorporeal blood purification to remove cytokines from the blood for patients undergoing cardiac valve replacement surgery using CPB. Methods: The hemoperfusion (HP) group consisted of 138 patients, who underwent a hemoperfusio

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Zuccari, Samuele, Elisa Damiani, Roberta Domizi, et al. "Changes in Cytokines, Haemodynamics and Microcirculation in Patients with Sepsis/Septic Shock Undergoing Continuous Renal Replacement Therapy and Blood Purification with CytoSorb." Blood Purification 49, no. 1-2 (2019): 107–13. http://dx.doi.org/10.1159/000502540.

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Background: Extracorporeal blood purification therapies have been proposed as a strategy to remove inflammatory mediators during sepsis, thus improving outcome. Objectives: We aimed to evaluate changes in cytokines, haemodynamics and microcirculation during blood purification with Cytosorb adsorber in septic patients. Methods: Prospective observational study on critically ill adult patients with sepsis/septic shock underwent renal replacement therapy (RRT) for acute renal failure and haemoadsorption with Cytosorb as adjunctive therapy for 24 h. Measurements were taken at baseline, after 6 and

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Seffer, Malin-Theres, Martin Weinert, Gabriella Molinari, et al. "Staphylococcus aureus binding to Seraph® 100 Microbind® Affinity Filter: Effects of surface protein expression and treatment duration." PLOS ONE 18, no. 3 (2023): e0283304. http://dx.doi.org/10.1371/journal.pone.0283304.

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Introduction Extracorporeal blood purification systems represent a promising alternative for treatment of blood stream infections with multiresistant bacteria. Objectives The aim of this study was to analyse the binding activity of S. aureus to Seraph affinity filters based on heparin coated beads and to identify effectors influencing this binding activity. Results To test the binding activity, we used gfp-expressing S. aureus Newman strains inoculated either in 0.9% NaCl or in blood plasma and determined the number of unbound bacteria by FACS analyses after passing through Seraph affinity fil

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Gaspari, Rita, Paola Aceto, Giorgia Spinazzola, et al. "Blood Purification in Hepatic Dysfunction after Liver Transplant or Extensive Hepatectomy: Far from the Best-Case Scenarios." Journal of Clinical Medicine 13, no. 10 (2024): 2853. http://dx.doi.org/10.3390/jcm13102853.

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Background: Hepatic dysfunction (HD) after liver transplantation (LT) or extended hepatic resection (EHR) is associated with graft failure and high short-term mortality. We evaluated the safety and depurative efficacy of CytoSorb® in these settings. The primary endpoint was the change in serum total bilirubin at the end of the treatment compared to the baseline value. The secondary endpoint was to evaluate the trend of serum total bilirubin and coagulation parameters up to 72 h after discontinuation of CytoSorb®. The effects of CytoSorb® therapy on the degree of hepatic encephalopathy (HE), Se

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Golubeva, Olga Yu, Yulia A. Alikina, Elena Yu Brazovskaya, and Nadezhda M. Vasilenko. "Adsorption Properties and Hemolytic Activity of Porous Aluminosilicates in a Simulated Body Fluid." ChemEngineering 6, no. 5 (2022): 78. http://dx.doi.org/10.3390/chemengineering6050078.

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A study of the adsorption features of bovine serum albumin (BSA), sodium and potassium cations, and vitamin B1 by porous aluminosilicates with different structures in a medium simulating blood plasma was conducted. The objects of this study were synthetic silicates with a montmorillonite structure Na2x(Al2(1-x),Mg2x)Si4O10(OH)2∙nH2O (x = 0.5, 0.9, 1), aluminosilicates of the kaolinite subgroup Al2Si2O5(OH)4 with different particle morphologies (spherical, nanosponge, nanotubular, and platy), as well as framed silicates (Beta zeolite). An assessment of the possibility of using aluminosilicates

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Góes, Cassiana Regina, Marina Nogueira Berbel, Andre Luis Balbi, and Daniela Ponce. "Approach to the Metabolic Implications of Peritoneal Dialysis in Acute Kidney Injury." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 35, no. 4 (2015): 397–405. http://dx.doi.org/10.3747/pdi.2013.00071.

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During the 1970s and 1980s, peritoneal dialysis (PD) was widely accepted as the standard treatment for acute kidney injury (AKI). However, advances in the techniques of extra-corporeal blood purification gradually reduced its use, making PD an underused modality in this context. Although PD for AKI is an underutilized modality worldwide, it is frequently used in developing countries because of its lower cost and minimal infrastructure requirements. Recent studies have shown that PD administered continuously through a flexible catheter and cycler is an effective treatment in AKI because it ensu

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Sinanović, Osman, Sanela Zukić, Adnan Burina, et al. "Plasmapheresis in neurological disorders: six years experience from University Clinical center Tuzla." F1000Research 6 (July 26, 2017): 1234. http://dx.doi.org/10.12688/f1000research.11841.1.

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Background: Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique that is designed to remove substances with a large molecular weight. The TPE procedure includes removal of antibodies, alloantibodies, immune complexes, monoclonal protein, toxins or cytokines, and involves the replenishment of a specific plasma factor. The aim of the study was to describe the clinical response to TPE in various neurological patients, and to assess the clinical response to this therapy. Methods: The study was retrospective. We analyzed the medical records of 77 patients who were tre

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Якубцевич, Р. Э., Н. В. Белявский, Е. А. Болдак та Н. А. Юсафзай. "Опыт применения фосфомицина натрия в интенсивной терапии сепсиса". Клиническая инфектология и паразитология 14, № 2 (2025): 223–33. https://doi.org/10.34883/pi.2025.14.2.043.

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Введение. В настоящее время антибактериальная терапия сепсиса в отделениях реанимации становится все более трудной задачей ввиду неуклонного роста резистентности микроорганизмов к антибактериальным препаратам. В связи с этим возникает необходимость оценить эффективность старых, давно не применявшихся препаратов, резистентность к которым могла быть утеряна естественным путем. Одним из таких препаратов является фосфомицин. Цель. Изучить результаты применения внутривенной формы фосфомицина натрия у пациентов с сепсисом различной этиологии. Материалы и методы. Изучены истории болезни 94 пациентов

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Łysenko, Lidia, Patrycja Leśnik, Kamil Nelke, and Hanna Gerber. "Immune disorders in sepsis and their treatment as a significant problem of modern intensive care." Postępy Higieny i Medycyny Doświadczalnej 71, no. 1 (2017): 0. http://dx.doi.org/10.5604/01.3001.0010.3849.

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Despite the great advances in the treatment of sepsis over the past 20 years, sepsis remains the main cause of death in intensive care units. In the context of new possibilities of treating sepsis, a comprehensive response of the immune system to the infection, immunosuppression, in particular, has in recent years gained considerable interest. There is vast evidence pointing to the correlation between comorbid immunosuppression and an increased risk of recurrent infections and death. Immune disorders may impact the clinical course of sepsis. This applies in particular to patients with deterior

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Huang, Chengshuang, Pei Huang, Xueqin Jiang, et al. "Control of Hypercytokinemia in Critically Ill Epstein-Barr Virus Related Hemophagocytic Lymphohistiocytosis with Plasma Exchange and Continuous Renal Replacement Therapy." Blood 134, Supplement_1 (2019): 2335. http://dx.doi.org/10.1182/blood-2019-122529.

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Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a severe and potentially fatal disease associated with abnormal function of the immune system. Epstein-Barr virus (EBV) is one of the most common triggers of HLH, especially in Asian countries. The control of EBV-HLH is still a challenging issue, particularly the early mortality, which was mainly due to the multi-organ failure coursed by hypercytokinemia. Therefore, control the hypercytokinemia induced by EBV are very important in critical ill EBV-HLH patients. Extracorporeal blood purification techniques already have been successfully

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Sofronov, Genrikh A., Elena V. Murzina, Alexey V. Denisov, Olga M. Veselova, and Tat'yana G. Krylova. "History of the research laboratory (medicinal and environmental toxicology) of the Military medical academy named after S.M. Kirov." Bulletin of the Russian Military Medical Academy 23, no. 3 (2021): 229–38. http://dx.doi.org/10.17816/brmma70376.

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This paper presents the history of the formation of the Research Department of the Experimental Medicine of the Research Center of the Military Medical Academy named after S.M. Kirov. The department is the only division of the academy that conducts experiments on animal models and field tests using laboratory animals in the interests of the Armed Forces of the Russian Federation. The paper also presents the main scientific achievements and development prospects of one of the three laboratories of the department Research Laboratory of Medicinal and Environmental Toxicology. In the direction of

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Kübler, Andrzej. "Extracorporeal blood purification in sepsis." Zakażenia XXI wieku 2019, no. 3 (2019): 115–19. http://dx.doi.org/10.31350/zakazenia/2019/3/z2019021.

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Monard, Céline, Thomas Rimmelé, and Claudio Ronco. "Extracorporeal Blood Purification Therapies for Sepsis." Blood Purification 47, Suppl. 3 (2019): 2–15. http://dx.doi.org/10.1159/000499520.

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Extracorporeal blood purification is proposed as an adjuvant therapy for sepsis, aiming at controlling the associated dysregulation of the immune system, which is known to induce organ dysfunctions. Different therapies have been developed to address certain steps of the immune dysregulation. Most of the available blood purification devices focus on a single target, such as the endotoxin that triggers the immune cascade, or the cytokine storm that causes organ damages. However, the highly adsorptive membrane named oXiris® is a unique 4-in-1 device that combines cytokine and endotoxin removal pr

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Rybalko, Andrey, Anna Pytal, Mikhail Kaabak, Nadejda Rappoport, Anuar Bidzhiev, and Vasilii Lastovka. "Case Report: Successful Use of Extracorporeal Therapies After ECMO Resuscitation in a Pediatric Kidney Transplant Recipient." Frontiers in Pediatrics 8 (December 15, 2020). http://dx.doi.org/10.3389/fped.2020.593123.

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The combination of extracorporeal membrane oxygenation (ECMO) and extracorporeal blood purification in children is rarely used due to small total blood volumes, risks of hemodynamic instability and a negative association between volume of blood transfusion and patient outcome. To our knowledge, this is the first description of a multimodal extracorporeal detoxication in the setting of ECMO in a post-kidney-transplant child on immunosuppression. We describe a case of a 30-months old child, who was extracorporeally resuscitated after cardiac arrest during kidney transplantation surgery and addit

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Rybalko, Andrey, Anna Pytal, Mikhail Kaabak, Nadejda Rappoport, Anuar Bidzhiev, and Vasilii Lastovka. "Case Report: Successful Use of Extracorporeal Therapies After ECMO Resuscitation in a Pediatric Kidney Transplant Recipient." Frontiers in Pediatrics 8 (December 15, 2020). http://dx.doi.org/10.3389/fped.2020.593123.

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The combination of extracorporeal membrane oxygenation (ECMO) and extracorporeal blood purification in children is rarely used due to small total blood volumes, risks of hemodynamic instability and a negative association between volume of blood transfusion and patient outcome. To our knowledge, this is the first description of a multimodal extracorporeal detoxication in the setting of ECMO in a post-kidney-transplant child on immunosuppression. We describe a case of a 30-months old child, who was extracorporeally resuscitated after cardiac arrest during kidney transplantation surgery and addit

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Onichimowski, Dariusz, Joanna Maria Wolska, Radosław Borysiuk, Marcin Mieszkowski, Zuzanna Stępień, and Ewa Mayzner-Zawadzka. "Practical issues of regional anticoagulation during continuous renal replacement therapy." Polish Annals of Medicine, 2019. http://dx.doi.org/10.29089/2019.19.00091.

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Introduction: Extracorporeal blood purification techniques have become a well-established part of routine practice in intensive care units. The issue of major concern while applying these techniques is to ensure appropriate anticoagulation to prevent the clotting of the circuit. Aim: The aim of this paper is to present regional anticoagulation as a method which is currently used in continuous extracorporeal blood purification techniques. Material and methods: This work is based on the available literature and the authors’ experience. Results and discussion: Anticoagulation used to prevent the

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Kuanyshbek, Aidyn, Bolat Bekishev, Tatyana LI, et al. "MO353: Extracorporeal Blood Purification of Complications After Aortic Valve Replacement. Surgical Aortic Valve Replacement Compared With Transcatheter Aortic Valve Replacement." Nephrology Dialysis Transplantation 37, Supplement_3 (2022). http://dx.doi.org/10.1093/ndt/gfac135.008.

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Abstract BACKGROUND AND AIMS Complications after cardiac surgery have serious negative consequences, prolonging the average ICU stay days and costs. Prevention and treatment of complications after aortic valve replacement is a serious problem. According to numerous authors, the incidence of complications after aortic valve replacement varies from 10 to &gt;60% of cases. Development of complications is associated with a higher hospital mortality rate, the risk of infection and a more complex course of the disease. Advances in cardiac surgery have led to a reduction in the overall mortality

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