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1

Schmidt, Gregory A., ed. Extracorporeal Life Support for Adults. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3005-0.

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2

Sangalli, Fabio, Nicolò Patroniti, and Antonio Pesenti, eds. ECMO-Extracorporeal Life Support in Adults. Milano: Springer Milan, 2014. http://dx.doi.org/10.1007/978-88-470-5427-1.

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3

M, Arensman Robert, and Cornish J. Devn, eds. Extracorporeal life support. Boston: Blackwell Scientific Publications, 1993.

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4

Dalton, Heidi J., Mark Davidson, and Peter P. Roeleveld. Extracorporeal Life Support. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199918027.003.0002.

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Extracorporeal membrane oxygenation (ECMO) can provide support as a bridge to recovery or a bridge to more definitive therapy for patients with severe respiratory or cardiorespiratory disease. In this chapter, the criteria for ECMO are discussed and a practical decision tree for mode of ECMO (venovenous or venoarterial) is presented. A stepwise approach to initiation and management of ECMO for the patient is described, including flow rate goals, ventilator management, anticoagulation, blood product replacement, identification of recovery, weaning procedures, and specific issues relating to the two different modes of ECMO.
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5

Dan M., M.D. Meyer and Michael E., M.D. Jessen. Extracorporeal Life Support (Vademecum). Landes Bioscience, 2001.

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6

Schmidt, Gregory A. Extracorporeal Life Support for Adults. Humana, 2016.

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7

Schmidt, Gregory A. Extracorporeal Life Support for Adults. Humana, 2015.

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8

Sangalli, Fabio, Nicolò Patroniti, and Antonio Pesenti. ECMO-Extracorporeal Life Support in Adults. Springer, 2014.

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9

Sangalli, Fabio, Nicolò Patroniti, and Antonio Pesenti. ECMO-Extracorporeal Life Support in Adults. Springer, 2016.

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10

Westrope, Claire, and Giles Peek. Extracorporeal respiratory and cardiac support techniques in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0104.

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Extra corporeal life support (ECLS) is an essential tool for the modern intensivist and surgeon. The addition of extracorporeal therapy should be considered in all cases when pathology is potentially reversible and conventional therapy is clearly failing. ECLS is a general term to describe prolonged, but temporary support of heart and lung function using mechanical devices, which has developed as an extension of cardiopulmonary bypass techniques used in the operating theatre. Use in adult severe respiratory and cardiac failure is increasing following significant advances in ECLS techniques learnt from paediatric and neonatal experiences, and successful use of extra corporeal membrane oxygenation in the 2009 and 2001 H1N1 (swine flu) outbreaks. This chapter describes the techniques required for providing successful ECLS in adult respiratory and cardiac failure.
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11

Pang, Diana, and Joseph A. Carcillo. Pediatric Shock. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199918027.003.0008.

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The chapter on pediatric shock recognition and management provides essential information on types of shock and its management. It contains summaries of hypovolemic, hemorrhagic, cardiogenic, vasoplegic, septic, metabolic, and dysoxic shock. All types of shock are best treated when therapy is targeted toward achieving specific goals (goal-directed therapy), and this chapter provides guidelines for clinical, hemodynamic, and biochemical goals. To achieve those goals, the chapter also provides guidelines on the use of key therapies, including isotonic crystalloid and colloid, blood products, catecholamines, inodilators, vasopressors, other medications (steroids, prostaglandin, triiodothyronine), and extracorporeal life support.
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12

Watson, MD, MPH, R. Scott, and Ann Thompson, MD, MHCPM, eds. Pediatric Intensive Care. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199918027.001.0001.

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Pediatric Intensive Care offers providers of critical care to children, from trainees to experienced clinicians, a concise, easy-to-carry resource on pediatric critical care medicine. It is designed for frequent and quick reference at the bedside, providing solutions to questions and situations encountered in practice. The 20 chapters are written by authorities in the field and include citations of some of the most essential references for further reading on each topic. The chapters cover key elements of the practice of pediatric critical care medicine, from cardiopulmonary resuscitation, monitoring, and procedures to extracorporeal life support, sedation and analgesia, and end of life care. Etiology and treatment of all types of organ failure are presented, as are chapters on toxicological emergencies/poisoning, critical care pharmacology, trauma, and burns. The book is sized to fit in a pocket, includes access to electronic, web-based content, and contains focused text, bulleted lists, tables, and figures. The book facilitates the delivery of critical care by residents, fellows, generalists in settings where critical care expertise is not readily available, and practicing intensivists.
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13

Roberts, Darren M. Decontamination and enhanced elimination of poisons. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0316.

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Decontamination and enhanced elimination are treatments that may be administered to patients with acute poisoning. They should not be used routinely in any patient, but initiated on a case-by-case basis after consideration of the type of poison, amount and time since exposure, anticipated clinical benefit, and other factors. Decontamination aims to decrease the severity and potential duration of poisoning. Activated charcoal is the most common form used and should be administered within 1–2 hours of poison ingestion. Enhanced elimination aims to decrease the duration and other consequences of poisoning. It is most commonly used for in severe poisoning with an agent that has a long elimination half-life. Elimination of a poison can be enhanced with extracorporeal therapies, multiple doses of activated charcoal, sodium polystyrene sulphate, and urinary alkalinization, although data support their use in selected cases only. To maximize poison clearance by haemodialysis or haemofiltration, the prescribed regimen may differ to that used for renal replacement therapy.
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14

Rady, Mohamed Y., and Ari R. Joffe. Non-heart-beating organ donation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0390.

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The transplantation community endorses controlled and uncontrolled non-heart-beating organ donation (NHBD) to increase the supply of transplantable organs at end of life. Cardiac arrest must occur within 1–2 hours after the withdrawal of life-support in controlled NHBD. Uncontrolled NHBD is performed after failed cardiopulmonary resuscitation in an unexpected witnessed cardiac arrest. Donor management aims to protect transplantable organs against warm ischaemic injury through the optimization of haemodynamics and mechanical ventilation. This also requires antemortem instrumentation and systemic anticoagulation for organ perseveration in controlled NHBD. Interval support with extracorporeal membrane oxygenation or cardiopulmonary bypass is generally required for optimal organ perfusion and oxygenation in uncontrolled NHBD, which remains a controversial medical practice. There are several unresolved ethical challenges. The circulatory criterion of 2–10 minutes of absent arterial pulse does not comply with the uniform determination of death criterion of the irreversible cessation of functions of the cardiovascular or central nervous systems. There are no robust safeguards in clinical practice that can prevent faulty prognostication, and premature withdrawal of treatment or termination of cardiopulmonary resuscitation. Unmanaged conflicting interests of increasing the supply of transplantable organs can have serious consequences on the medical care of potentially salvageable patients. Perimortem interventions can interfere with the delivery of an optimal quality of end-of-life care. The lack of disclosure of these NHBD ethical controversies does not uphold the moral obligation for an informed consent.
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15

Sampson, Brett G., and Andrew D. Bersten. Therapeutic approach to bronchospasm and asthma. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0111.

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The optimal management of bronchospasm and acute asthma is reliant upon confirmation of the diagnosis of asthma, detection of life-threatening complications, recognition of β‎2 agonist toxicity, and exclusion of important asthma mimics (such as vocal cord dysfunction and left ventricular failure). β‎2 agonists, anticholinergics, and corticosteroids are the mainstay of treatment. β‎2 agonists should be preferentially administered by metered dose inhaler via a spacer, and corticosteroids by the oral route, reserving nebulized (and intravenous) salbutamol, as well as intravenous hydrocortisone, for situations when these routes are not possible. A single intravenous dose of magnesium may be of benefit in severe asthma, but repeat dosing is likely to cause serious side effects. Parenteral administration of adrenaline may prevent the need for intubation in the patient in extremis. Aminophylline has an unfavourable side effect profile and has not been shown to offer additional benefit in adults. However, it does have a role in paediatric asthma. Unproven medical therapies with potential benefit include ketamine, heliox, inhalational anaesthetics, and leukotriene antagonists. The need for ventilatory support is usually preceded by worsening dynamic hyperinflation, exhaustion, hypoxia, reduced conscious state, or a combination of these. While non-invasive ventilation may have a temporizing role to allow time for response to medical therapy, there is insufficient evidence for its use, and should not delay invasive ventilation. If invasive ventilation is indicated, a strategy of hypoventilation and permissive hypercapnoea, minimizes barotrauma and dynamic hyperinflation. Extracorporeal support may have a role as a rescue therapy.
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