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Journal articles on the topic 'Extreme regulator'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Quatrini, R., C. Lefimil, D. S. Holmes, and E. Jedlicki. "The ferric iron uptake regulator (Fur) from the extreme acidophile Acidithiobacillus ferrooxidans." Microbiology 151, no. 6 (2005): 2005–15. http://dx.doi.org/10.1099/mic.0.27581-0.

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Acidithiobacillus ferrooxidans is a Gram-negative bacterium that lives at pH 2 in high concentrations of soluble ferrous and ferric iron, making it an interesting model for understanding the biological mechanisms of bacterial iron uptake and homeostasis in extremely acid conditions. A candidate fur AF (Ferric Uptake Regulator) gene was identified in the A. ferrooxidans ATCC 23270 genome. FurAF has significant sequence similarity, including conservation of functional motifs, to known Fur orthologues and exhibits cross-reactivity to Escherichia coli Fur antiserum. The fur AF gene is able to comp

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Guo, Qiannan, Yuhua Zhan, Wei Zhang, et al. "Development and Regulation of the Extreme Biofilm Formation of Deinococcus radiodurans R1 under Extreme Environmental Conditions." International Journal of Molecular Sciences 25, no. 1 (2023): 421. http://dx.doi.org/10.3390/ijms25010421.

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To grow in various harsh environments, extremophiles have developed extraordinary strategies such as biofilm formation, which is an extremely complex and progressive process. However, the genetic elements and exact mechanisms underlying extreme biofilm formation remain enigmatic. Here, we characterized the biofilm-forming ability of Deinococcus radiodurans in vitro under extreme environmental conditions and found that extremely high concentrations of NaCl or sorbitol could induce biofilm formation. Meantime, the survival ability of biofilm cells was superior to that of planktonic cells in diff

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3

Ciren, Danielle, Sophia Zebell, and Zachary B. Lippman. "Extreme restructuring of cis-regulatory regions controlling a deeply conserved plant stem cell regulator." PLOS Genetics 20, no. 3 (2024): e1011174. http://dx.doi.org/10.1371/journal.pgen.1011174.

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A striking paradox is that genes with conserved protein sequence, function and expression pattern over deep time often exhibit extremely divergent cis-regulatory sequences. It remains unclear how such drastic cis-regulatory evolution across species allows preservation of gene function, and to what extent these differences influence how cis-regulatory variation arising within species impacts phenotypic change. Here, we investigated these questions using a plant stem cell regulator conserved in expression pattern and function over ~125 million years. Using in-vivo genome editing in two distantly

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Cao, Yu-An, Amy J. Wagers, Holger Karsunky, et al. "Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors." Blood 112, no. 12 (2008): 4494–502. http://dx.doi.org/10.1182/blood-2007-12-127621.

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Abstract An effective response to extreme hematopoietic stress requires an extreme elevation in hematopoiesis and preservation of hematopoietic stem cells (HSCs). These diametrically opposed processes are likely to be regulated by genes that mediate cellular adaptation to physiologic stress. Herein, we show that heme oxygenase-1 (HO-1), the inducible isozyme of heme degradation, is a key regulator of these processes. Mice lacking one allele of HO-1 (HO-1+/−) showed accelerated hematopoietic recovery from myelotoxic injury, and HO-1+/− HSCs repopulated lethally irradiated recipients with more r

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Kulіnchenko, Heorhіi, Petro Leontiev, and Oleksii Drozdenko. "Development of extreme regulator of separation moisture from the gas stream." ScienceRise, no. 2 (April 30, 2021): 3–10. http://dx.doi.org/10.21303/2313-8416.2021.001815.

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Object of study: Automation of control of technological parameters of the process of low-temperature separation (LTS) of moisture from a gas stream. Investigated problem: Improving the efficiency of the separation process when preparing gas for transportation through the consumption network. Development of hardware and software tools that provide automation of the process of regulating flow parameters under conditions of action of time-varying disturbances. Main scientific results: A criterion for controlling the LTS process of a gas flow is formulated. The difference in the dynami

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Kulіnchenko, Heorhіi, Petro Leontiev, and Oleksii Drozdenko. "Development of extreme regulator of separation moisture from the gas stream." ScienceRise, no. 2 (April 30, 2021): 3–10. https://doi.org/10.21303/2313-8416.2021.001815.

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Object of study: Automation of control of technological parameters of the process of low-temperature separation (LTS) of moisture from a gas stream. Investigated problem: Improving the efficiency of the separation process when preparing gas for transportation through the consumption network. Development of hardware and software tools that provide automation of the process of regulating flow parameters under conditions of action of time-varying disturbances. Main scientific results: A criterion for controlling the LTS process of a gas flow is formulated. The difference in the dynamic characteri

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7

Huang, Jie. "On the Robust Regulator for Linear Systems With Limited Parameter Uncertainty." Journal of Dynamic Systems, Measurement, and Control 123, no. 2 (1999): 248–52. http://dx.doi.org/10.1115/1.1368112.

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The linear servomechanism problem has been studied for two extreme cases. On one extreme, the problem has been studied without considering the plant parameter uncertainty. On the other extreme, the problem has been studied for the worst parameter uncertainty in the sense that all the plant parameters are allowed to vary arbitrarily in the neighborhoods of their nominal values. Between these two extreme cases is what will be called limited uncertainty case where the entries of the plant matrices vary functionally with respect to some variables. This case will be studied in this paper. The main

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8

Lefimil, C., E. Jedlicki та D. S. Holmes. "α-fur, an antisense RNA gene to fur in the extreme acidophile Acidithiobacillus ferrooxidans". Microbiology 160, № 3 (2014): 514–24. http://dx.doi.org/10.1099/mic.0.073171-0.

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A large non-coding RNA, termed α-Fur, of ~1000 nt has been detected in the extreme acidophile Acidithiobacillus ferrooxidans encoded on the antisense strand to the iron-responsive master regulator fur (ferric uptake regulator) gene. A promoter for α-fur was predicted bioinformatically and validated using gene fusion experiments. The promoter is situated within the coding region and in the same sense as proB, potentially encoding a glutamate 5-kinase. The 3′ termination site of the α-fur transcript was determined by 3′ rapid amplification of cDNA ends to lie 7 nt downstream of the start of tran

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9

Kliuiev, O., and B. Stupak. "OPTIMIZATION OF THE REACTIVE POWER ROTOR CIRCLE OF THE DOUBLY FED MACHINE." Sciences of Europe, no. 127 (October 25, 2023): 111–18. https://doi.org/10.5281/zenodo.10039446.

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The energy characteristics of the doubly fed machine as a function of its state variables were obtained and their analysis was carried out. It is proven that the power coefficients of the stator and rotor circuits can be optimized in static modes by adjusting the magnitude of the stator flux coupling module and the reactive component of the rotor current. The properties of the analytical expressions of the quality functions of the extreme regulation of the doubly fed machine are analyzed taking into account the saturation effect of the magnetic circuit of the asynchronous machine. The values o

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10

Polianskiy, V. P. "Parametric synthesis of the optimal regulator on the basis of the calculus of variations for General mathematical model of the object." Izvestiya MGTU MAMI 7, no. 3-2 (2013): 181–86. http://dx.doi.org/10.17816/2074-0530-68140.

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The article discusses the parametric synthesis of the optimal regulator based on the calculus of variations, provided that the mathematical model of an object is represented by a differential equation in the operator form and the left and right parts in the form of algebraic polynomials of relative variable . In the same form is submitted mathematical model of the regulator. On this basis the system of Euler-Poisson equations for extreme variational problem is obtained. After equating the coefficients of the polynomials optimal problem and polynomials obtained from the initial equations of the

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11

Hitomi, Yutaka, Caryn E. Outten, and Thomas V. O'Halloran. "Extreme Zinc-Binding Thermodynamics of the Metal Sensor/Regulator Protein, ZntR." Journal of the American Chemical Society 123, no. 35 (2001): 8614–15. http://dx.doi.org/10.1021/ja016146v.

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12

Keramova, S. N. "EXTREME NEED AS AN INSTITUTE OF SELF-DEFENSE IN ADMINISTRATIVE LAW." Law Нerald of Dagestan State University 35, no. 3 (2020): 67–70. http://dx.doi.org/10.21779/2224-0241-2020-35-3-67-70.

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The article analyzes the features of such a measure of self-defense as the institution of extreme necessity in administrative law, and examines judicial practice in such cases. It is stated that extreme necessity is a circumstance that excludes administrative responsibility of a person for the committed offense. Criteria of extreme necessity are listed. It is noted that the Code of administrative offences of the Russian Federation contains conditions for the use of extreme necessity. The need for three conditions to exclude the illegality of an administrative offense and release a person from

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13

Waterbury, Julie A., Larry L. Jackson, and Paul Schedl. "Analysis of the Doublesex Female Protein in Drosophila melanogaster: Role in Sexual Differentiation and Behavior and Dependence on Intersex." Genetics 152, no. 4 (1999): 1653–67. http://dx.doi.org/10.1093/genetics/152.4.1653.

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Abstract doublesex (dsx) is unusual among the known sex-determination genes of Drosophila melanogaster in that functional homologs are found in distantly related species. In flies, dsx occupies a position near the bottom of the sex determination hierarchy. It is expressed in male- and female-specific forms and these proteins function as sex-specific transcription factors. In the studies reported here, we have ectopically expressed the female Dsx protein (DsxF) from a constitutive promoter and examined its regulatory activities independent of other upstream factors involved in female sex determ

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14

Савеленко, Григорий Владимирович, and Юрий Алексеевич Ермолаев. "Extreme regulator structure grounding of automated process productivity of electric discharge machining." Technology audit and production reserves 6, no. 4(20) (2014): 42. http://dx.doi.org/10.15587/2312-8372.2014.32750.

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15

Hussell, Tracy, and Mary M. Cavanagh. "The innate immune rheostat: influence on lung inflammatory disease and secondary bacterial pneumonia." Biochemical Society Transactions 37, no. 4 (2009): 811–13. http://dx.doi.org/10.1042/bst0370811.

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The activity of innate immunity is not simply dictated by the presence of an antigen but also by the balance between negative regulatory and immune potentiator pathways. Even in the absence of antigen, innate immunity can ‘inflame’ if negative regulators are absent. This resting state is adaptable and dictated by environmental influences, host genetics and past infection history. A return to homoeostasis post inflammation may therefore not leave the tissue in an identical state to that prior to the inflammatory event. This adaptability makes us all unique and also explains the variable outcome

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16

Wang, Liangyan, Guangzhi Xu, Huan Chen, et al. "DrRRA: a novel response regulator essential for the extreme radioresistance of Deinococcus radiodurans." Molecular Microbiology 67, no. 6 (2008): 1211–22. http://dx.doi.org/10.1111/j.1365-2958.2008.06113.x.

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17

Stiazhkin, V. P., O. A. Zaichenko, S. I. Gavryluk, O. M. Ryzhkov, V. I. Teriaiev, and N. D. Krasnoshapka. "COMBINED CONTROL OF GEARLESS ARC-CORE SHIP RADAR ANTENNA ELECTRIC DRIVE WITH FUZZY LOGIC REGULATOR." Tekhnichna Elektrodynamika 2023, no. 3 (2023): 60–67. http://dx.doi.org/10.15407/techned2023.03.060.

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The synthesis of a fuzzy proportional-integral-differential speed regulator of the arc stator electric drive of the rotation of the radar station antenna with combined control was carried out. The structural diagram of the fuzzy regulator was developed, the input and output linguistic variables are defined, the rule base was compiled, the dependence surfaces of the output control variable on the input coordinates are obtained. A simulation model of an electric drive in the Matlab system with a synthesized fuzzy logic regulator based on a two-phase model of an asynchronous arc-stator motor was

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18

Kubbutat, Michael H. G., Robert L. Ludwig, Margaret Ashcroft, and Karen H. Vousden. "Regulation of Mdm2-Directed Degradation by the C Terminus of p53." Molecular and Cellular Biology 18, no. 10 (1998): 5690–98. http://dx.doi.org/10.1128/mcb.18.10.5690.

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ABSTRACT The stability of the p53 tumor suppressor protein is regulated by interaction with Mdm2, the product of a p53-inducible gene. Mdm2-targeted degradation of p53 depends on the interaction between the two proteins and is mediated by the proteasome. We show here that in addition to the N-terminal Mdm2 binding domain, the C terminus of p53 participates in the ability of p53 to be degraded by Mdm2. In contrast, alterations in the central DNA binding domain of p53, which change the conformation of the p53 protein, do not abrogate the sensitivity of the protein to Mdm2-mediated degradation. T

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19

Agnes Zahrani, Aniq A. Rohmawati, and Siti Sa’adah. "STL Decomposition and SARIMA Model: The Case for Estimating Value-at-Risk of Covid-19 Increment Rate in DKI Jakarta." International Journal on Information and Communication Technology (IJoICT) 7, no. 2 (2021): 1–10. http://dx.doi.org/10.21108/ijoict.v7i2.553.

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In this research, we propose an extreme values measure, the Value-at-Risk (VaR) based Seasonal Trend Loess (STL) Decomposition and Seasonal Autoregressive Integrated Moving Average (SARIMA) models, which is more sensitive to the seasonality of extreme value than the conventional VaR. We consider the problem of the seasonality and extreme value for increment rate of Covid-19 forecasting. For stakeholder, government and regulator, VaR estimation can be implemented to face the extreme wave of new positive Covid-19 in the future and minimize the losses that possibly affected in term of financial a

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20

Vasilieva, S. V., V. N. Zeyruk, M. K. Derevyagina, G. L. Belov, and E. A. Kolesova. "The effectiveness of the plant growth regulator Atonic Plus on potatoes in the conditions of the Moscow region." Vegetable crops of Russia, no. 3 (June 23, 2022): 82–89. http://dx.doi.org/10.18619/2072-9146-2022-3-82-89.

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The results of evaluating the effectiveness of the plant growth regulator Atonic Plus on potatoes as a stimulator of development, immunomodulator and protectant of the negative effects of pesticides in the crop protection system in the agro-climatic conditions of the Central region of the Russian Federation (Moscow region) are presented.In the extreme weather conditions of the growing season of 2010, the growth regulator Atonic Plus effectively demonstrated its qualities in the form of the formation of adaptability and anti-stress resistance in potato plants, providing an increase in yield rel

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21

Yagi, Keisuke, Noriyuki Hori, and Meyer Nahon. "EXPERIMENTAL VERIFICATION OF A PRACTICAL DIGITAL DRIVER WITH SWITCHED GAIN-TUNING FOR FIVE-PHASE STEPPING-MOTORS." Transactions of the Canadian Society for Mechanical Engineering 39, no. 2 (2015): 239–52. http://dx.doi.org/10.1139/tcsme-2015-0017.

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A digital driver that has a switched self-tuning gain in its current regulator is designed for five-phase stepping motors so that their performance could be improved and adjusted more easily, than with an analog driver. The regulator has a fixed gain block in its feedback loop and an adjustable gain in the feedforward path, replacing the integrator and the high gain that were required in previous designs to achieve good steady-state performance and fast response. Extensive experiments have been conducted under typical and extreme actuation conditions, and revealed that the proposed driver perf

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22

Hamza, Ali, Muhammad Uneeb, Iftikhar Ahmad, Komal Saleem, and Zunaib Ali. "Variable Structure-Based Control for Dynamic Temperature Setpoint Regulation in Hospital Extreme Healthcare Zones." Energies 16, no. 10 (2023): 4223. http://dx.doi.org/10.3390/en16104223.

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In critical healthcare units, such as operation theaters and intensive care units, healthcare workers require specific temperature environments at different stages of an operation, which depends upon the condition of the patient and the requirements of the surgical procedures. Therefore, the need for a dynamically controlled temperature environment and the availability of the required heating/cooling electric power is relatively more necessary for the provision of a better healthcare environment as compared to other commercial and residential buildings, where only comfortable room temperature

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23

Enoru-Eta, Julius, Daniel Gigot, Thia-Lin Thia-Toong, Nicolas Glansdorff, and Daniel Charlier. "Purification and Characterization of Sa-Lrp, a DNA-Binding Protein from the Extreme Thermoacidophilic ArchaeonSulfolobus acidocaldarius Homologous to the Bacterial Global Transcriptional Regulator Lrp." Journal of Bacteriology 182, no. 13 (2000): 3661–72. http://dx.doi.org/10.1128/jb.182.13.3661-3672.2000.

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ABSTRACT Archaea, constituting the third primary domain of life, harbor a basal transcription apparatus of the eukaryotic type, whereas curiously, a large fraction of the potential transcription regulation factors appear to be of the bacterial type. To date, little information is available on these predicted regulators and on the intriguing interplay that necessarily has to occur with the transcription machinery. Here, we focus on Sa-lrp of the extremely thermoacidophilic crenarchaeote Sulfolobus acidocaldarius, encoding an archaeal homologue of the Escherichia colileucine-responsive regulator

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Zaini, Paulo A., Andréa C. Fogaça, Fernanda G. N. Lupo, Helder I. Nakaya, Ricardo Z. N. Vêncio, and Aline M. da Silva. "The Iron Stimulon of Xylella fastidiosa Includes Genes for Type IV Pilus and Colicin V-Like Bacteriocins." Journal of Bacteriology 190, no. 7 (2008): 2368–78. http://dx.doi.org/10.1128/jb.01495-07.

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ABSTRACTXylella fastidiosais the etiologic agent of a wide range of plant diseases, including citrus variegated chlorosis (CVC), a major threat to citrus industry. The genomes of several strains of this phytopathogen were completely sequenced, enabling large-scale functional studies. DNA microarrays representing 2,608 (91.6%) coding sequences (CDS) ofX. fastidiosaCVC strain 9a5c were used to investigate transcript levels during growth with different iron availabilities. When treated with the iron chelator 2,2′-dipyridyl, 193 CDS were considered up-regulated and 216 were considered down-regulat

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Al-Tameemi, Amro, and Hayder Al-Thamiry. "The Extreme Flood Capacity of Al-Majjarah Canal and Regulator Within Al-Ramadi Project System." Al-Nahrain Journal for Engineering Sciences 26, no. 3 (2023): 235–43. http://dx.doi.org/10.29194/njes.26030235.

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It is essential to review and develop a system of water control structures and canals that can be used to manage high-flow discharges and the flood control plan requirement to modify the system's capacity. Al-Ramadi Project System is considered one of the main flood control projects on the Euphrates River within Anbar Governorate, Western Iraq. This study will focus on Al-Majjarah Canal and Regulator, which is part of Al-Ramadi Project and has the function of a link canal between Al-Habbaniyah and Al-Razazza lakes, and describe the capacity of the canal under typical operating conditions and d

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Fuller, C. M., M. B. Howard, D. M. Bedwell, R. A. Frizzell, and D. J. Benos. "Antibodies against the cystic fibrosis transmembrane regulator." American Journal of Physiology-Cell Physiology 262, no. 2 (1992): C396—C404. http://dx.doi.org/10.1152/ajpcell.1992.262.2.c396.

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Rabbit polyclonal antibodies have been raised against high-performance liquid chromatography purified synthetic peptides corresponding to two discrete regions of the cystic fibrosis transmembrane regulator (CFTR) protein: the R-domain (residues 785-796) and the extreme COOH-terminus (residues 1467-1480). Antibodies (Ab) to each of these peptides were affinity purified either by passage over a peptide-derivatized agarose matrix (Ab 785) to produce monospecific polyclonal antibodies or by protein A affinity chromatography to purify the immunoglobulin G1 fraction free of other serum proteins (Ab

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Shi, Y., P. E. Kroeger, and R. I. Morimoto. "The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive." Molecular and Cellular Biology 15, no. 8 (1995): 4309–18. http://dx.doi.org/10.1128/mcb.15.8.4309.

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We have characterized a stress-responsive transcriptional activation domain of mouse heat shock factor 1 (HSF1) by using chimeric GAL4-HSF1 fusion proteins. Fusion of the GAL4 DNA-binding domain to residues 124 to 503 of HSF1 results in a chimeric factor that binds DNA yet lacks any transcriptional activity. Transactivation is acquired upon exposure to heat shock or by deletion of a negative regulatory domain including part of the DNA-binding-domain-proximal leucine zippers. Analysis of a collection of GAL4-HSF1 deletion mutants revealed the minimal region for the constitutive transcriptional

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Pan, Changtian, Dandan Yang, Xiaolin Zhao, et al. "PIF4 negatively modulates cold tolerance in tomato anthers via temperature-dependent regulation of tapetal cell death." Plant Cell 33, no. 7 (2021): 2320–39. http://dx.doi.org/10.1093/plcell/koab120.

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Abstract Extreme temperature conditions seriously impair male reproductive development in plants; however, the molecular mechanisms underlying the response of anthers to extreme temperatures remain poorly described. The transcription factor phytochrome-interacting factor4 (PIF4) acts as a hub that integrates multiple signaling pathways to regulate thermosensory growth and architectural adaptation in plants. Here, we report that SlPIF4 in tomato (Solanum lycopersicum) plays a pivotal role in regulating cold tolerance in anthers. CRISPR (clustered regularly interspaced short palindromic repeats)

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Kump, Lee R. "Prolonged Late Permian–Early Triassic hyperthermal: failure of climate regulation?" Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 376, no. 2130 (2018): 20170078. http://dx.doi.org/10.1098/rsta.2017.0078.

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The extreme warmth associated with the mass extinction at the Permian–Triassic boundary was likely produced by a rapid build-up of carbon dioxide in the atmosphere from the eruption and emplacement of the Siberian Traps. In comparison to another hyperthermal event, the Palaeocene–Eocene Thermal Maximum, the Permian–Triassic event, while leaving a similar carbon isotope record, likely had larger amounts of CO 2 emitted and did not follow the expected time scale of climate recovery. The quantities and rates of CO 2 emission likely exhausted the capacity of the long-term climate regulator associa

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Collavin, L. "The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm." Development 130, no. 4 (2003): 805–16. http://dx.doi.org/10.1242/dev.00306.

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Stodolka¹, Jacek, Marian Golema², and Juliusz Migasiewicz. "Balance Maintenance in the Upright Body Position: Analysis of Autocorrelation." Journal of Human Kinetics 50, no. 1 (2016): 45–52. http://dx.doi.org/10.1515/hukin-2015-0140.

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Abstract The present research aimed to analyze values of the autocorrelation function measured for different time values of ground reaction forces during stable upright standing. It was hypothesized that if recording of force in time depended on the quality and way of regulating force by the central nervous system (as a regulator), then the application of autocorrelation for time series in the analysis of force changes in time function would allow to determine regulator properties and its functioning. The study was performed on 82 subjects (students, athletes, senior and junior soccer players

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Luo, Xinrong, Zhanwen Liu, Xiaoxia Luo, et al. "Genome Mining Reveals Rifamycin Biosynthesis in a Taklamakan Desert Actinomycete." Microorganisms 13, no. 5 (2025): 1068. https://doi.org/10.3390/microorganisms13051068.

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Actinomycetes are recognized for producing diverse bioactive natural products, yet most biosynthetic gene clusters (BGCs) remain inactive under laboratory conditions. Rare actinomycetes from extreme environments represent underexplored reservoirs of metabolic potential. This study investigates Actinomadura sp. TRM71106, a rare actinomycete isolated from the Taklamakan Desert, through integrated genomic and metabolomic approaches. Genome sequencing revealed 45 secondary metabolic BGCs, including BGC38 showing 65% nucleotide similarity to the rifamycin BGC. Gene cluster networking and linear com

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Sanober, Gul, Jamil Ahmed, Rehan Zafar Paracha, et al. "Helicobacter pylori Virulence Regulatory Network: Insights into the Host-Environment and Pathogen Interactions." NUST Journal of Natural Sciences 3, no. 1 (2021): 65–77. http://dx.doi.org/10.53992/njns.v3i1.22.

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Helicobacter pylori (H. pylori) has evolved significant regulatory mechanisms in order to acclimatize in extreme gastric environment of human beings. The virulence machinery of H. pylori is complicated as virulence factors of pathogen not only interact with transcription and translational machinery of host, but also are involved in the progression and development of the disease. The present study is an effort to model virulence mechanism in H. pylori, particularly ferric uptake regulator (FUR) under acidic and iron (Fe) depleted conditions, as well as its effects on the well known virulence fa

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Heuser, Michael, Damian B. Yap, Malina Leung, et al. "Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation." Blood 113, no. 7 (2009): 1432–43. http://dx.doi.org/10.1182/blood-2008-06-162263.

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Abstract MLL5 is a divergent member of the Drosophila Trithorax-related (SET) domain and plant homeodomain (PHD) domain-containing chromatin regulators that are involved in the regulation of transcriptional “memory” during differentiation. Human MLL5 is located on chromosome 7q22, which frequently is deleted in myeloid leukemias, suggesting a possible role in hemopoiesis. To address this question, we generated a loss-of-function allele (Mll5tm1Apa) in the murine Mll5 locus. Unlike other Mll genes, Mll5tm1Apa homozygous mice are viable but display defects in immunity and hematopoiesis. First, M

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Wu, Liping, Ran Zhou, Junshan Bao, et al. "Vehicle Stability Analysis under Extreme Operating Conditions Based on LQR Control." Sensors 22, no. 24 (2022): 9791. http://dx.doi.org/10.3390/s22249791.

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Under extreme working conditions such as high-speed driving on roads with a large road surface unevenness coefficient, turning on a road with a low road surface adhesion coefficient, and emergency acceleration and braking, a vehicle’s stability deteriorates sharply and reduces ride comfort. There is extensive existing research on vehicle active suspension control, trajectory tracking, and control methods. However, most of these studies focus on conventional operating conditions, while vehicle stability analysis under extreme operating conditions is much less studied. In order to improve the st

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Macanguisse, Joaquim, Luis Cristovao, Nicolas Vignoli, Silvia Orioli, and Cesar Correa Jaik. "Strategies to enhance energy availability in Mozambique: A comparison of national electricity market regulations and strategies to encourage grid-integrated distributed renewable energy generation." Research, Society and Development 11, no. 7 (2022): e51311730103. http://dx.doi.org/10.33448/rsd-v11i7.30103.

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The energy sector in Mozambique faces huge challenges that include low generation capacity and efficiency, affordability, unstable and unreliable energy supplies, low access rates, amongst others. The situation is being worsened by high environmental, social vulnerability and extreme events influenced by climate catastrophes. With the demand of energy consistently on the rise, there is critical need to address policy, investment, market and technical barriers to energy sector development. Mozambican government has made tremendous effort in developing electricity sector regulatory frameworks. H

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Schwarz, R., and A. R. Grossman. "A response regulator of cyanobacteria integrates diverse environmental signals and is critical for survival under extreme conditions." Proceedings of the National Academy of Sciences 95, no. 18 (1998): 11008–13. http://dx.doi.org/10.1073/pnas.95.18.11008.

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Ait, Ahmed Wassima, Mohammed Aggour, and Badr Ouhammou. "Development of an inexpensive data logger for solar water heating system regulators." International Journal of Power Electronics and Drive System (IJPEDS) 10, no. 2 (2019): 753–67. https://doi.org/10.11591/ijpeds.v10.i2.pp753-767.

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Each solar thermal plant can provide different parameters to be treated and evaluated, mostly temperature measurements, pressure specifications, heat transfer values. This data collection can be quite expensive taking into account the important number of sensors and data loggers and their specifications. Hence to assure flexibility in the data collection at a low cost, many hardware and software specifications can be adopted. Here we built an inexpensive data logger based on the Arduino board and IDE to collect and store incoming data from Resol DeltaSol regulators integrated in different sola

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McCue, B. M., R. L. Greenwell, M. I. Laurence, B. J. Blalock, S. K. Islam, and L. M. Tolbert. "SOI Based Voltage Regulator for High-Temperature Applications." Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT) 2012, HITEC (2012): 000207–13. http://dx.doi.org/10.4071/hitec-2012-wp12.

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Developments in automotive (particularly hybrid-electric vehicles), aerospace, and energy production industries have led to expanding research interest in integrated circuit (IC) design toward high-temperature applications. A high-voltage, high-temperature silicon-on-insulator (SOI) process allows for circuit design to expand into these extreme environment applications. Nearly all electronic devices require a reliable supply voltage capable of operating under various supply voltages and load currents. These supply voltages and load currents can be either DC or time-varying signals. In this wor

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Zou, Guihua, Guowei Zhai, Song Yan, et al. "Sorghum qTGW1a encodes a G-protein subunit and acts as a negative regulator of grain size." Journal of Experimental Botany 71, no. 18 (2020): 5389–401. http://dx.doi.org/10.1093/jxb/eraa277.

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Abstract Grain size is a major determinant of grain yield in sorghum and other cereals. Over 100 quantitative trait loci (QTLs) of grain size have been identified in sorghum. However, no gene underlying any grain size QTL has been cloned. Here, we describe the fine mapping and cloning of one grain size QTL. From an F8 recombinant inbred line population derived from a cross between inbred lines 654 and LTR108, we identified 44 grain size QTLs. One QTL, qTGW1a, was detected consistently on the long arm of chromosome 1 in the span of 4 years. Using the extreme recombinants from an F2:3 fine-mappi

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Grangeat, Anibal Martin, and Maria de los Angeles Erario. "The Use of Medical Ozone in Chronic Intervertebral Disc Degeneration Can Be an Etiological and Conservative Treatment." International Journal of Molecular Sciences 24, no. 7 (2023): 6538. http://dx.doi.org/10.3390/ijms24076538.

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Degeneration of the intervertebral disc is one of the most frequent causes of lumbar pain, and it puts an extreme strain on worldwide healthcare systems. Finding a solution for this disease is an important challenge as current surgical and conservative treatments fail to bring a short-term or long-term solution to the problem. Medical ozone has yielded excellent results in intervertebral disc pathology. When it comes to extruded disc herniation, ozone is the only etiological treatment because it stimulates the immune system to absorb the herniated portion of the nucleus pulposus, thus resolvin

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Baker-Austin, Craig, Mark Dopson, Margaret Wexler, R. Gary Sawers, and Philip L. Bond. "Molecular insight into extreme copper resistance in the extremophilic archaeon ‘Ferroplasma acidarmanus’ Fer1." Microbiology 151, no. 8 (2005): 2637–46. http://dx.doi.org/10.1099/mic.0.28076-0.

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‘Ferroplasma acidarmanus’ strain Fer1 is an extremely acidophilic archaeon involved in the genesis of acid mine drainage, and was isolated from copper-contaminated mine solutions at Iron Mountain, CA, USA. Here, the initial proteomic and molecular investigation of Cu2+ resistance in this archaeon is presented. Analysis of Cu2+ toxicity via batch growth experiments and inhibition of oxygen uptake in the presence of ferrous iron demonstrated that Fer1 can grow and respire in the presence of 20 g Cu2+ l−1. The Fer1 copper resistance (cop) loci [originally detected by Ettema, T. J. G., Huynen, M.

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Wassima, Ait ahmed, Aggour Mohammed, and Ouhammou Badr. "Development of an inexpensive data logger for solar water heating system regulators." International Journal of Power Electronics and Drive Systems (IJPEDS) 10, no. 2 (2019): 753. http://dx.doi.org/10.11591/ijpeds.v10.i2.pp753-767.

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<p>Each solar thermal plant can provide different parameters to be treated and evaluated, mostly temperature measurements, pressure specifications, heat transfer values. This data collection can be quite expensive taking into account the important number of sensors and data loggers and their specifications. Hence to assure flexibility in the data collection at a low cost, many hardware and software specifications can be adopted. Here we built an inexpensive data logger based on the Arduino board and IDE to collect and store incoming data from Resol DeltaSol regulators integrated in diffe

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Martínez de Morentin, Pablo B., Adela Urisarri, María L. Couce, and Miguel López. "Molecular mechanisms of appetite and obesity: a role for brain AMPK." Clinical Science 130, no. 19 (2016): 1697–709. http://dx.doi.org/10.1042/cs20160048.

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Feeding behaviour and energy storage are both crucial aspects of survival. Thus, it is of fundamental importance to understand the molecular mechanisms regulating these basic processes. The AMP-activated protein kinase (AMPK) has been revealed as one of the key molecules modulating energy homoeostasis. Indeed, AMPK appears to be essential for translating nutritional and energy requirements into generation of an adequate neuronal response, particularly in two areas of the brain, the hypothalamus and the hindbrain. Failure of this physiological response can lead to energy imbalance, ultimately w

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Ansari, A., and M. R. Gartenberg. "The yeast silent information regulator Sir4p anchors and partitions plasmids." Molecular and Cellular Biology 17, no. 12 (1997): 7061–68. http://dx.doi.org/10.1128/mcb.17.12.7061.

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Circular plasmids containing telomeric TG1-3 arrays or the HMR E silencer segregate efficiently between dividing cells of the yeast Saccharomyces cerevisiae. Subtelomeric X repeats augment the TG1-3 partitioning activity by a process that requires the SIR2, SIR3, and SIR4 genes, which are also required for silencer-based partitioning. Here we show that targeting Sir4p to DNA directly via fusion to the bacterial repressor LexA confers efficient mitotic segregation to otherwise unstable plasmids. The Sir4p partitioning activity resides within a 300-amino-acid region (residues 950 to 1262) which

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Sicilia, Angelo, Gorgio Testa, Danilo Fabrizio Santoro, Salvatore Luciano Cosentino, Angela Roberta, and Lo Piero. "RNASeq analysis of giant cane reveals the leaf transcriptome dynamics under longterm salt stress." BMC Plant Biology 2019 (June 4, 2019): 19:335. https://doi.org/10.1186/s12870-019-1964-y.

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To compensate for the lack of information about the molecular mechanism involved in Arundo donax L. response to salt stress, we de novo sequenced, assembled and analyzed the A. donax leaf transcriptome subjected to two levels of long-term salt stress (namely, S3 severe and S4 extreme).The picture that emerges from the identification of differentially expressed genes is consistent with a salt dose-dependent response. Hence, a deeper re programming of the gene expression occurs in those plants grew at extreme salt level than in those subjected to severe salt stress, probably representing for the

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Michurina, S. V., S. I. Kolesnikov, A. L. Bochkareva, I. Yu Ishchenko, and S. A. Arkhipov. "Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat Ovarian Follicular Apparatus during Recovery after Extreme Hypothermia." Bulletin of Experimental Biology and Medicine 168, no. 2 (2019): 205–9. http://dx.doi.org/10.1007/s10517-019-04675-x.

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Santos, Thalyta Soares dos, Ana Carla Dos Santos Gomes, Maytê Duarte Leal Coutinho, Allan Rodrigues Silva, and Aline Anderson de Castro. "Análise de Eventos Extremos na Região Amazônica (Analysis of Extreme Events in the Amazon Region)." Revista Brasileira de Geografia Física 6, no. 5 (2013): 1356. http://dx.doi.org/10.26848/rbgf.v6i5.233109.

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A frequência de eventos severos e extremos de seca e chuva na Amazônia foi analisada utilizando o Índice de Precipitação Normalizada (SPI) nas escalas de 6 (sazonal estação seca/chuvosa) e 12 meses (interanual). A frequência de eventos secos e chuvosos é importante para a climatologia da região, que é considerada um regulador climático global. Para isso foram selecionadas as séries climatológicas, de 1925 a 2000, de seis localidades da região Amazônica: Belém, Cuiabá, Iauretê, Manaus, Porto Velho, Taguatinga. Os SPIs, 6 e 12, que quantificam excesso ou déficit de chuva, nestas duas escalas de

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Vijayvergia, Namrata, Suraj Peri, Karthik Devarajan, et al. "RNA profiling of neuroendocrine tumors (NETs) to define new targets and mechanisms of progression." Journal of Clinical Oncology 35, no. 4_suppl (2017): 302. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.302.

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302 Background: NETs lack mutations in the “classical” signaling pathways but share mutations in regulators of gene expression (Jiao; 2011). We compared gene expression in PD & WD NETs to identify novel targets and biomarkers of differentiation. Methods: High quality RNA, extracted from paraffin blocks of deidentified NETs under an IRB-approved protocol, was profiled using a 770 gene panel (nCounter PanCancer pathway, Nanostring Technologies). The resulting data was used to identify the differentially expressed genes between PD and WD NETs using limma software (Ritchie; 2015). Gene Set Enr

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Dicle, Mehmet F., and Kendra Reed. "Asymmetric return response to expected risk: policy implications." Journal of Financial Regulation and Compliance 27, no. 3 (2019): 345–56. http://dx.doi.org/10.1108/jfrc-01-2018-0004.

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Purpose As investors’ fear has an impact on their risk-return tradeoff, this fear leaves markets susceptible to sudden and large fluctuations. The purpose of this study is to suggest regulators to amend their precautionary methods to recognize the difference in investor behavior for high-risk periods versus low-risk periods. Design/methodology/approach The authors empirically show the difference in investor response to changes in expected risk as a function of level of risk. They then show different return patterns for high-risk and low-risk days. Their approach is implemented to evaluate whet

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