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1

Paquette, Roland, Ryan Bierle, David Wampler, et al. "External Soft-Tissue Hemostatic Clamp Compared to a Compression Tourniquet as Primary Hemorrhage Control Device in Pilot Flow Model Study." Prehospital and Disaster Medicine 34, no. 02 (2019): 175–81. http://dx.doi.org/10.1017/s1049023x19000037.

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Introduction:Acute blood loss represents a leading cause of death in both civilian and battlefield trauma, despite the prioritization of massive hemorrhage control by well-adopted trauma guidelines. Current Tactical Combat Casualty Care (TCCC) and Tactical Emergency Casualty Care (TECC) guidelines recommend the application of a tourniquet to treat life-threatening extremity hemorrhages. While extremely effective at controlling blood loss, the proper application of a tourniquet is associated with severe pain and could lead to transient loss of limb function impeding the ability to self-extricat
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Igarashi, Yutaka, Narumi Matsumoto, Tatsuhiko Kubo, Ryuta Nakae, Shoji Yokobori, and Hiroyuki Yokota. "A Systematic Review of Earthquake-Related Head Injuries." Prehospital and Disaster Medicine 34, s1 (2019): s171. http://dx.doi.org/10.1017/s1049023x19003911.

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Introduction:Earthquakes have killed around 800,000 people globally in the past 20 years, with head injury being the main cause of mortality and morbidity.Aim:To conduct a systematic review to determine the characteristics of head injuries after earthquakes for better disaster preparedness and management.Methods:All publications related to head injuries and earthquakes were searched using Pubmed, Web of Science, the Cochrane Library, and Ichushi.Results:Thirty-six articles were included in the analysis. Head injury was the third most common cause of injury among survivors of earthquakes. The m
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Abbas, Kashif, Masood Umer, and Haroon ur Rashid. "Complex Biological Reconstruction after Wide Excision of Osteogenic Sarcoma in Lower Extremities." Plastic Surgery International 2013 (January 17, 2013): 1–5. http://dx.doi.org/10.1155/2013/538364.

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Wide margin resection of extremity tumor sometimes leaves a huge soft tissue and bony defects in limb salvage surgery. Adequate management of these defects is an absolute requirement when aiming for functional limb. Multidisciplinary management in such cases is an answer when complex biologic reconstruction is desired. We aim to present cases of osteogenic sarcoma of lower extremity requiring combined surgical approach to achieve effective musculoskeletal reconstruction. Patients and Methods. From 2006 to 2010 ten patients were operated on for osteogenic sarcoma of lower extremity requiring co
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Qin, Hao, Daocheng Liu, Sixu Chen, et al. "First-aid Training for Combatants Without Systematic Medical Education Experience on the Battlefield: Establishment and Evaluation of the Curriculum in China." Military Medicine 185, no. 9-10 (2020): e1822-e1828. http://dx.doi.org/10.1093/milmed/usaa152.

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Abstract Introduction For combatants without systematic medical education experience (CSMEE), it is necessary to participate in first-aid on the battlefield, but currently there is no effective training curriculum for CSMEE in Chinese military. Materials and Methods A list of first-aid techniques based on expert consensus was formed, and then a curriculum was established according to the list. The effectiveness of the curriculum was further evaluated by comparing the scores among group A (the reserve officers trained by this curriculum), group B (the reserve officers in the military medical co
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5

Schauer, Steven Gremel, Andrew Fisher, James Bynum, and Andrew P. Cap. "Defining the Super Massive Transfusion in US and Coalition Forces during Combat Operations in Afghanistan and Iraq." Blood 136, Supplement 1 (2020): 5–6. http://dx.doi.org/10.1182/blood-2020-143199.

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Introduction: Hemorrhage is the leading cause of potentially preventable death on the battlefield. After hemorrhage control, the resuscitation with blood products is essential to restore circulating volume and prevent coagulopathy. While massive transfusion (MT) occurs frequently after major trauma, it remains unclear who the subset of casualties is that define a super massive transfusion which would require mobilization of additional resources. We seek to determine what defines a super MT as this would help allocate resources. Methods: This is a secondary analysis of a previously described da
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Nitecki, Samy S., Tony Karram, Amos Ofer, Ahuva Engel, and Aaron Hoffman. "Management of Combat Vascular Injuries Using Modern Imaging: Are We Getting Better?" Emergency Medicine International 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/689473.

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Background. Vascular injuries often result in life threatening hemorrhage or limb loss. When they present with a single entry or exit wound, surgery is immediately indicated. With multiple injuries, however, imaging such as CTA is necessary for diagnosis and choice of treatment.Methods. For all combat-related vascular cases admitted to our medical center during the Lebanon wars in 1982 and 2006, we compiled and compared presenting signs and symptoms, means of diagnosis, treatments, and results.Results. 126 patients with vascular injuries were admitted (87 in 1982, 39 in 2006). 90% were male; m
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Banitt, Michael R., Allison Rand, Robin R. Vann, and Steven J. Gedde. "Bilateral intraocular hemorrhage from vascularization of cataract wounds." Journal of Cataract & Refractive Surgery 35, no. 9 (2009): 1637–39. http://dx.doi.org/10.1016/j.jcrs.2009.05.007.

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8

Day, Michael W. "Control of Traumatic Extremity Hemorrhage." Critical Care Nurse 36, no. 1 (2016): 40–51. http://dx.doi.org/10.4037/ccn2016871.

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Although most extremity hemorrhage from trauma can be controlled with direct pressure and/or pressure dressings, the occasional uncontrolled hemorrhage can be life threatening. Tools that may be able to control such life-threatening extremity hemorrhage include hemostatic dressings, tourniquets, and several new devices that have recently become available. Hemostatic dressings, a relatively new concept, incorporate materials that increase coagulation into a dressing that is applied directly to the wound. Although the use of tourniquets has a long history, recent military conflicts have provided
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9

Schauer, Steven Gremel, Andrew Fisher, Matthew Borgman, Andrew P. Cap, and James Bynum. "Defining the Super Massive Transfusion in Pediatric Casualties during Combat Operations in Afghanistan and Iraq." Blood 136, Supplement 1 (2020): 25. http://dx.doi.org/10.1182/blood-2020-143238.

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Introduction: Hemorrhage is the leading cause of potentially preventable death on the battlefield. We previously published data defining the pediatric massive transfusion at 40mL/kg of total blood products. However, there is a subset of casualties that require large volumes of blood products - super massive transfusions - which remains unclear. We seek to determine what defines a super massive transfusion within the pediatric population as understanding this unique group would help mobilize resources early in their clinical course. Methods: This is a secondary analysis of a previously describe
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10

Anglin, Deirdre, H. Range Hutson, Joseph Luftman, Stephanie Qualls, and Doris Moradzadeh. "Intracranial Hemorrhage Associated with Tangential Gunshot Wounds to the Head." Academic Emergency Medicine 5, no. 7 (1998): 672–78. http://dx.doi.org/10.1111/j.1553-2712.1998.tb02484.x.

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11

Mount, Gillian, Michael J. Kovacs, Alejandro Lazo-Langner, Lenicio Siqueira, and Martha L. Louzada. "Safety of Weight-Adjusted Dosing of LMWH in Clinically Obese Cancer Patients with Venous Thromboembolism." Blood 128, no. 22 (2016): 882. http://dx.doi.org/10.1182/blood.v128.22.882.882.

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Abstract Background: Obesity, defined as a body mass index (BMI) greater than 30 kg/m2, is a well-known risk factor for venous thromboembolism (VTE). Despite this observation, obese patients are under-represented in anticoagulation safety trials. Current guidelines recommend patients with active malignancy and VTE to be treated with long-term low molecular weight heparin (LMWH), but it is unclear whether this practice is safe in obese cancer patients. Objectives: We hypothesized there would be an increased risk of major or clinically significant non-major bleeding in obese cancer patients rece
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12

Chan, Victoria, and Chloe Gui. "Novel hemorrhage control technologies and their potential applicability in trauma medicine." University of Western Ontario Medical Journal 86, no. 1 (2017): 46–48. http://dx.doi.org/10.5206/uwomj.v86i1.2177.

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Mortality due to hemorrhage is potentially preventable but remains a prevalent problem in trauma care. Despite advances in prehospital hemorrhage control, exsanguination remains the leading and second-leading cause of mortality in military and civilian trauma, respectively. Novel hemorrhage control technologies for military and civilian prehospital use include the iTClamp (iTraumaCare, Edmonton, Canada), a mechanical clamp used to close wounds; XStat (RevMedx, Wilsonville, OR), a syringe applicator that injects expandable cellulose sponges into a wound for internal compression and clotting acc
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13

Cooke, William H., Kathy L. Ryan, and Victor A. Convertino. "Lower body negative pressure as a model to study progression to acute hemorrhagic shock in humans." Journal of Applied Physiology 96, no. 4 (2004): 1249–61. http://dx.doi.org/10.1152/japplphysiol.01155.2003.

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Hemorrhage is a leading cause of death in both civilian and battlefield trauma. Survival rates increase when victims requiring immediate intervention are correctly identified in a mass-casualty situation, but methods of prioritizing casualties based on current triage algorithms are severely limited. Development of effective procedures to predict the magnitude of hemorrhage and the likelihood for progression to hemorrhagic shock must necessarily be based on carefully controlled human experimentation, but controlled study of severe hemorrhage in humans is not possible. It may be possible to simu
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Miyagi, Yasushi, Fumio Shima, Katsuya Ishido, Masashi Moriguchi, and Kazufumi Kamikaseda. "Posteroventral pallidotomy for midbrain tremor after a pontine hemorrhage." Journal of Neurosurgery 91, no. 5 (1999): 885–88. http://dx.doi.org/10.3171/jns.1999.91.5.0885.

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✓ This 49-year-old man gradually developed a disabling action tremor in the proximal right upper extremity 8 months after suffering a pontine tegmental hemorrhage. The intraoperative microrecording in the nucleus ventralis intermedius (VIM) of the left thalamus revealed tremor-synchronous grouped discharges with a vigorous (2.7 Hz) action tremor predominantly in the shoulder and upper arm. High frequency electrical stimulation in the VIM did not affect the tremor. A posteroventral pallidotomy (PVP) was performed and resulted in the successful alleviation of all tremor activity. Posteroventral
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15

Ždrale, Slavko, and Marko Vuković. "Cardiac War Wounds." Acta Facultatis Medicae Naissensis 33, no. 2 (2016): 135–40. http://dx.doi.org/10.1515/afmnai-2016-0015.

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Summary The paper presents myocardial contusion and penetrating cardiac war wounds. The authors report their experience with thirteen cases of penetrating wounds, out of which only two were treated in the conditions acceptable for surgery. The other 11 wounds were treated in war hospitals which were mostly improvised, and in mobile surgical teams. The basic, exclusively physical examination methods are described here, with the emphasis that “it is better to open and see than wait and see”. Such procedure gave the results that could be compared with the best ones in the literature (only one dea
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Greer, Lauren T., Bhavin Patel, Katherine C. Via, Jonathan N. Bowman, Michael A. Weber, and Charles J. Fox. "Management of secondary hemorrhage from early graft failure in military extremity wounds." Journal of Trauma and Acute Care Surgery 73, no. 4 (2012): 818–24. http://dx.doi.org/10.1097/ta.0b013e3182587f32.

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17

Stuart, Sean M., Gregory Zarow, Alexandra Walchak, Julie McLean, and Paul Roszko. "Pilot Study of a Novel Swine Model for Controlling Junctional Hemorrhage Using the iTClamp in Conjunction With Hemostatic Agents." Military Medicine 184, Supplement_1 (2019): 367–73. http://dx.doi.org/10.1093/milmed/usy337.

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Abstract Exsanguinating hemorrhage is a primary cause of battlefield death. The iTClamp is a relatively new device (FDA approval in 2013) that takes a different approach to hemorrhage control by applying mechanism wound closure. However, no previous studies have explored the feasibility of utilizing the iTClamp in conjunction with hemostatic packing. To fill this important gap in the literature, a novel swine model was developed, and a total of 12 trials were performed using QuikClot Combat Gauze or XSTAT sponges in conjunction with the iTClamp to treat arterial injuries through 5 cm or 10 cm
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18

Samokhvalov, I. M., K. P. Golovko, V. V. Boyarintsev, et al. "Concept formulation for the early-stage pathogenetic treatment of the severe injuries and traumas." Bulletin of the Russian Military Medical Academy 22, no. 3 (2020): 23–28. http://dx.doi.org/10.17816/brmma50526.

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Abstract. 451 lethal outcomes of 5581 casualties with gunshot wounds occurring at the medical treatment facilities have been analyzed. Total lethality rate was 8,1%. Lethal outcome time varied from 1 to 19 days (10,61,9). 50,3% of casualties died during the advanced trauma management (Role 2), 17,3% at the Role 3 hospitals, 32,4% at the Role 4 hospitals. The predominant injury localization causing death was abdominal wounds 34,8%, and head injuries 23,1%. The main cause of death of wounds casualties arriving at the medical treatment facilities was life-threatening injury consequences (34,8%) a
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Blaivas, Michael, Stephen Shiver, Matthew Lyon, and Srikar Adhikari. "Control of Hemorrhage in Critical Femoral or Inguinal Penetrating Wounds—An Ultrasound Evaluation." Prehospital and Disaster Medicine 21, no. 6 (2006): 379–82. http://dx.doi.org/10.1017/s1049023x00004076.

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AbstractIntroduction:Exsanguination from a femoral artery wound can occur in sec-onds and may be encountered more often due to increased use of body armor. Some military physicians teach compression of the distal abdominal aorta (Abdominal Aorta) with a knee or a fist as a temporizing measure.Objective:The objective of this study was to evaluate if complete collapse of the Abdominal Aorta was feasible and with what weight it occurs.Methods:This was a prospective, interventional study at a Level-I, academ-ic, urban, emergency department with an annual census of 80,000 patients. Written, informe
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Yankin, Igor, Michael Schaer, Matthew Johnson, Tessa Meland, and Leonel A. Londoño. "Persistent pit viper envenomation in a cat." Journal of Feline Medicine and Surgery Open Reports 3, no. 2 (2017): 205511691773746. http://dx.doi.org/10.1177/2055116917737463.

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Case summary A 4-year-old female spayed, indoor/outdoor domestic mediumhair cat presented with multiple bleeding puncture wounds and hemorrhagic shock. The cat was diagnosed with suspected pit viper envenomation based on the location and appearance of the bite wounds, as well as the presence of severe coagulopathy with prolonged activated coagulation time (762 s), which responded to antivenom administration. The clinical course of the cat was unique owing to the prolonged clinical signs of envenomation that appeared as intermittent coagulopathy and hemorrhage over a 2 week period. Five vials o
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Trujillo, Maximo H., and Kaduo Arai. "Hydrothorax After Inadvertent Placement of a Central Venous Catheter in the Left Pericardiophrenic Vein." Journal of Intensive Care Medicine 9, no. 5 (1994): 257–60. http://dx.doi.org/10.1177/088506669400900505.

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Angiography has a central role In both diagnosis and therapy of traumatic vascular injuries from blunt and penetrating mechanisms. Angiography is considered the “gold standard” for establishing the presence of vascular injury, but precise indications and appropriate timing of angiography in certain clinical situations, such as proximity injury to the extremities or penetrating neck injuries, remain controversial. We consider the role of angiography in the diagnosis of major arterial injury in the thorax, selective use of diagnostic and therapeutic angiography for intraabdominal trauma, identif
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Landers, Grace D., Cassandra Townsend, Micah Gaspary, et al. "Efficacy of Hemostatic Gauzes in a Swine Model of Prolonged Field Care with Limb Movement." Military Medicine 186, Supplement_1 (2021): 384–90. http://dx.doi.org/10.1093/milmed/usaa403.

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ABSTRACT Introduction Prolonged field care for junctional wounds is challenging and involves limb movement to facilitate transport. No studies to date have explored the efficacy of gauze products to limit rebleeding in these scenarios. Materials and Methods We randomly assigned 48 swine to QuikClot Combat Gauze, ChitoGauze, NuStat Tactical, or Kerlix treatment groups (12 each) and then inflicted a severe groin injury by utilizing a modified Kheirabadi model of a 6-mm femoral artery punch followed by unrestricted bleeding for 60 seconds. We reassessed rebleed following limb movement at 30 minut
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Maurin, Olga, Stanislas de Régloix, Stéphane Dubourdieu, et al. "Maxillofacial Gunshot Wounds." Prehospital and Disaster Medicine 30, no. 3 (2015): 316–19. http://dx.doi.org/10.1017/s1049023x1500463x.

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AbstractThe majority of maxillofacial gunshot wounds are caused by suicide attempts. Young men are affected most often. When the lower one-third of the face is involved, airway patency (1.6% of the cases) and hemorrhage control (1.9% of the cases) are the two most urgent complications to monitor and prevent. Spinal fractures are observed with 10% of maxillary injuries and in 20% of orbital injuries. Actions to treat the facial gunshot victim need to be performed, keeping in mind spine immobilization until radiographic imaging is complete and any required spinal stabilization accomplished. Pati
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Park, Chan Wook, Seok Jong Chung, Young H. Sohn, and Phil Hyu Lee. "A Case of Abnormal Postures in the Left Extremities after Pontine Hemorrhage: Dystonia or Pseudodystonia?" Journal of Movement Disorders 13, no. 1 (2020): 62–65. http://dx.doi.org/10.14802/jmd.19074.

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Li, Qing, Enling Hu, Kun Yu, et al. "Self‐Propelling Janus Particles for Hemostasis in Perforating and Irregular Wounds with Massive Hemorrhage." Advanced Functional Materials 30, no. 42 (2020): 2004153. http://dx.doi.org/10.1002/adfm.202004153.

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Kawakyu-O'Connor, Don, Mariano Scalgione, and Refky Nicola. "Imaging of Vascular Injuries of the Extremities." Seminars in Musculoskeletal Radiology 21, no. 03 (2017): 336–48. http://dx.doi.org/10.1055/s-0037-1602410.

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Multidetector computed tomography angiography (MDCTA) of the upper and lower extremities is the standard of care in the assessment of trauma patients with vascular trauma of the upper and lower extremities. A MDCTA of the extremities is typically integrated into multiphasic whole-body computed tomography trauma protocols in patients with suspected vascular injury. MDCTA has replaced catheter-directed digital subtraction angiography (DSA) as the modality of choice for the initial detection and characterization of vascular injuries because it is readily available, noninvasive, and faster than DS
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Kara, M. Isa, Hidayet B. Polat, and Sinan Ay. "Penetrated Shotgun Pellets: A Case Report." European Journal of Dentistry 02, no. 01 (2008): 59–62. http://dx.doi.org/10.1055/s-0039-1697355.

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ABSTRACTShotgun wounds can result in devastating functional and aesthetic consequences for patients. There is no consensus in terms of removing or retaining foreign bodies such as shotgun pellets. In this report a 54-year-old man who suffered from accidental shotgun wounds on the face approximately 26 years ago is presented. Although most of pellets were still present, there were no symptoms such as poisoning, fistula formation, recurrent infections, or secondary hemorrhage to date except feeling cold in cold days. (Eur J Dent 2008;2:59-62)
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Karibe, Hiroshi, Hiroaki Shimizu, Teiji Tominaga, Keiji Koshu, and Takashi Yoshimoto. "Diffusion-weighted magnetic resonance imaging in the early evaluation of corticospinal tract injury to predict functional motor outcome in patients with deep intracerebral hemorrhage." Journal of Neurosurgery 92, no. 1 (2000): 58–63. http://dx.doi.org/10.3171/jns.2000.92.1.0058.

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Object. Diffusion-weighted (DW) magnetic resonance imaging was used to visualize corticospinal tract injury in patients with deep intracerebral hemorrhage (ICH), and the results were used to predict motor impairment of the extremities.Methods. Twenty-eight patients with deep ICH (17 men and 11 women, mean age 58 ± 14 years) were examined. The volume of the ICH was assessed on initial computerized tomography scans. Twelve patients had ICH volumes of 40 ml or more and were treated surgically, and 16 patients who had an ICH volume of less than 40 ml were treated medically. Initial corticospinal t
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Wang, Liu, Cherng, et al. "Biological Effects of Chitosan-Based Dressing on Hemostasis Mechanism." Polymers 11, no. 11 (2019): 1906. http://dx.doi.org/10.3390/polym11111906.

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: There have been numerous recent advances in wound care management. Nevertheless, the assessment of hemostatic dressing is essential to enable surgeons and other physicians and healthcare professionals to make the correct decisions regarding the disposition of severe hemorrhage. Here, we investigated the relative efficacies of chitosan-based and conventional gauze dressings in a rat model of femoral artery hemorrhage and in patients with surgical wounds. Dressing effectiveness was evaluated based on hemostatic profiles, biocompatibility, antimicrobial activity, and blood factor responses in c
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Herring, Carl J., Alan B. Lumsden, and Suzie C. Tindall. "Transcranial Stab Wounds: A Report of Three Cases and Suggestions for Management." Neurosurgery 23, no. 5 (1988): 658–62. http://dx.doi.org/10.1227/00006123-198811000-00022.

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Abstract Transcranial stab wounds are uncommon. Three such cases are presented. The severity of the wounds may vary from innocuous to devastating. Skull films are useful in delineating the depth of penetration. The presence of the knife blade in situ may make the computed tomographic scan impossible to perform or difficult to interpret. Cerebral angiography may be indicated if injury to a major cerebral vessel is suspected or if the patient suffers a delayed subarachnoid or intracerebral hemorrhage. Provided that the patient's clinical status indicates a positive prognosis, transcranial stab w
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Waldron, James S., Michael C. Oh, and Dean Chou. "Lumbar Subdural Hematoma From Intracranial Subarachnoid Hemorrhage Presenting With Bilateral Foot Drop: Case Report." Neurosurgery 68, no. 3 (2011): E835—E839. http://dx.doi.org/10.1227/neu.0b013e3182078099.

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Abstract BACKGROUND AND IMPORTANCE: We report a patient with lumbar subdural hematoma secondary to intracranial subarachnoid hemorrhage (SAH) presenting with bilateral foot drop and describe our management. CLINICAL PRESENTATION: A 37-year-old woman presented with grade 4 SAH and hydrocephalus requiring emergent external ventricular drainage. Angiography demonstrated a left vertebral artery dissection and pseudoaneurysm that was treated with embolization of the vertebral artery. Six days after admission, her neurologic examination significantly improved. She was awake, alert, following command
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Awad, Issam A., and Gene H. Barnett. "Neurological deterioration in a patient with a spinal arteriovenous malformation following lumbar puncture." Journal of Neurosurgery 72, no. 4 (1990): 650–53. http://dx.doi.org/10.3171/jns.1990.72.4.0650.

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✓ The mechanism of nonhemorrhagic neurological deterioration from spinal arteriovenous malformation (AVM) and the role of acute surgical intervention in this setting are not well understood. The case is described of a 65-year-old man who presented with a 2-year history of mild gait spasticity and vague sensory complaints affecting both lower extremities. Following a diagnostic lumbar puncture, these symptoms progressed painlessly over a 4-day period to total motor paraplegia, urinary retention, and hypesthesia in all modalities with a midthoracic sensory level. Magnetic resonance imaging showe
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Enriquez-Marulanda, Alejandro, Abdulrahman Y. Alturki, Kimberly Kicielinski, Ajith J. Thomas, and Christopher S. Ogilvy. "C5-C6 Cervical Spinal Cord Cavernous Malformation Microsurgical Resection: 2-Dimensional Operative Video." Operative Neurosurgery 16, no. 1 (2018): E7. http://dx.doi.org/10.1093/ons/opy066.

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Abstract We describe the case of a previously healthy 44-yr-old female patient presenting with a sudden onset of numbness, paresthesias, and decreased sensation in her lower limbs. Physical examination revealed a decreased sensation to vibration and light touch in her lower extremities, primarily in the left limb. Impaired proprioception was also evident primarily in the left toe. Full strength with 2+ reflexes was observed in all extremities. Magnetic resonance imaging demonstrated an exophytic lesion in the posterior aspect of the cervical spinal cord at the C5-C6 level, with a hemosiderin h
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Ran, Yuval, Eran Hadad, Saleh Daher, et al. "QuikClot Combat Gauze Use for Hemorrhage Control in Military Trauma: January 2009 Israel Defense Force Experience in the Gaza Strip—A Preliminary Report of 14 Cases." Prehospital and Disaster Medicine 25, no. 6 (2010): 584–88. http://dx.doi.org/10.1017/s1049023x00008797.

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AbstractBackground:Standard gauze field dressings and direct pressure occasionally are inadequate for the control of hemorrhage. QuikClot® Combat Gauze™ (QCG) combines surgical gauze with an inorganic material and is approved by the Food and Drug Administration and by the Israeli Standards Institute for external hemorrhage control. The purpose of this article is to report clinical use of this dressing during Operation Cast Lead in the Gaza strip during January 2009.Methods:QuikClot Combat Gauze and the QCG guidelines were issued to advanced life support (ALS) providers during the preparations
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Baylis, James R., Ju Hun Yeon, Max H. Thomson, et al. "Self-propelled particles that transport cargo through flowing blood and halt hemorrhage." Science Advances 1, no. 9 (2015): e1500379. http://dx.doi.org/10.1126/sciadv.1500379.

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Delivering therapeutics deep into damaged tissue during bleeding is challenging because of the outward flow of blood. When coagulants cannot reach and clot blood at its source, uncontrolled bleeding can occur and increase surgical complications and fatalities. Self-propelling particles have been proposed as a strategy for transporting agents upstream through blood. Many nanoparticle and microparticle systems exhibiting autonomous or collective movement have been developed, but propulsion has not been used successfully in blood or used in vivo to transport therapeutics. We show that simple gas-
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El Halabi, Sarah, Jaafar Al Shami, Ghadir Hijazi, Zakaria Alameddine, Maher Ghandour, and Ali Saad. "A Case Report: Rare Presentation of Intracranial Hemorrhage post Guillain Barré Syndrome." International Journal of Clinical Research 1, no. 1 (2020): 109–12. http://dx.doi.org/10.38179/ijcr.v1i1.23.

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Background: Guillain Barre Syndrome (GBS) is an autoimmune disease where antibodies attack the myelin sheath of peripheral nerves. The hallmark of the disease includes symmetrical quadriparesis, respiratory distress, and failure with subsequent need for mechanical ventilation. Most cases occur after a viral or bacterial infection. Other causes, such as intracranial hemorrhage, also exist, and several case studies report an association between these two pathologies. Case Report: In this report, we present the case of an elderly male patient with intracranial (IC) bleeding post-GBS. The patient
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Sawada, Ryoko, Yusuke Shinoda, Aya Niimi, et al. "Multiple Acrometastases in a Patient with Renal Pelvic Urothelial Cancer." Case Reports in Urology 2017 (2017): 1–4. http://dx.doi.org/10.1155/2017/7830207.

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Metastasis may occur in any bone but more commonly occurs in the spine, pelvis, or other axial bones. Metastasis in peripheral bones located distal to the elbow or knee, so-called acrometastasis, is rare. Although the mechanism of acrometastasis development is not completely understood, it is thought to be the result of a massive dissemination of cancer cells; thus the prognosis of patients with acrometastasis is relatively poor. Here, we report the case of renal pelvic cancer with multiple acrometastases in both the upper and lower extremities without axial bone metastasis in a 68-year-old ma
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Kapur, Sakshi, Michael Wax, Levin Miles, and Adnan Hussain. "Permanent Sensorineural Deafness in a Patient with Chronic Myelogenous Leukemia Secondary to Intracranial Hemorrhage." Case Reports in Hematology 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/894141.

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A 52-year-old male presented with tinnitus and fullness in left ear for one day. Workup revealed a white blood cell count of685×103/μL with marked increase in granulocyte series and myeloid precursors on peripheral smear. The initial impression was chronic myelogenous leukemia with hyperleukocytosis, and patient was started on hydration, hydroxyurea, and allopurinol. Patient tolerated bone marrow biopsy well but continued to bleed excessively from the biopsy site. Results confirmed Philadelphia chromosome positive chronic myelogenous leukemia (chronic phase). On day three of hospitalization, p
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Echenique, Joanna V. Z., Mauro P. Soares, Francisco A. Uzal, et al. "Blackleg in a free-range brown brocket deer (Mazama gouazoubira)." Pesquisa Veterinária Brasileira 38, no. 12 (2018): 2262–65. http://dx.doi.org/10.1590/1678-5150-pvb-5914.

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ABSTRACT: A case of blackleg in a brown brocket deer (Mazama gouazoubira) associated with trauma from being hit by a car in southern Rio Grande do Sul is reported. The clinical signs included fever, dehydration and lethargy that worsened progressively until 36 hours after the accident, when the animal died. In the fore right limb, there was a comminuted closed fracture of the radius and ulna but no skin wounds were observed. Grossly, the musculature of the pelvic limbs presented hemorrhage, edema and emphysema. Microscopically, the muscles of both rear legs had necrosis, edema, hemorrhage and
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Gulbahar, Gultekin, Tevfik Kaplan, Ahmet Gokhan Gundogdu, et al. "A Rare and Serious Syndrome That Requires Attention in Emergency Service: Traumatic Asphyxia." Case Reports in Emergency Medicine 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/359814.

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Traumatic asphyxia is a rare syndrome caused by blunt thoracoabdominal trauma and characterized by cyanosis, edema, and subconjunctival and petechial hemorrhage on the face, neck, upper extremities, and the upper parts of the thorax. Traumatic asphyxia is usually diagnosed by history and inspection; however, the patient should be monitored more closely due to probable complications of thoracoabdominal injuries. Treatment is conservative, but the prognosis depends on the severity of the associated injuries. Herein we present a traumatic asphyxia due to an elevator accident in a 32-year-old male
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Sato, Kenichi, Luca Roccatagliata, Sebastien Depuydt, and Georges Rodesch. "Multiple Aneurysms of Thoracic Spinal Cord Arteries Presenting With Spinal Infarction and Subarachnoid Hemorrhage." Neurosurgery 71, no. 5 (2012): E1053—E1058. http://dx.doi.org/10.1227/neu.0b013e3182647be4.

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Abstract BACKGROUND AND IMPORTANCE: Arterial aneurysms of the spinal cord are rare. Their pathogenesis is variable, and the therapeutic strategies remain controversial, because their natural history is unclear. We report a case of multiple dissecting aneurysms of radiculomedullary and radiculopial arteries presenting with spinal infarction and subarachnoid hemorrhage, which spontaneously resolved. CLINICAL PRESENTATION: A 67-year-old woman was hospitalized owing to sudden onset of severe back pain with discomfort in the lower extremities. Two days later, she again experienced sudden back pain
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Hattori, Naoyuki, Yoichi Katayama, Yoshio Maya, and Alexander Gatherer. "Impact of stereotactic hematoma evacuation on activities of daily living during the chronic period following spontaneous putaminal hemorrhage: a randomized study." Journal of Neurosurgery 101, no. 3 (2004): 417–20. http://dx.doi.org/10.3171/jns.2004.101.3.0417.

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Object. Stereotactic evacuation of hematoma has been reported to reduce the incidence of mortality and to improve functional outcome in patients with spontaneous putaminal hemorrhage. Stereotactic evacuation of hematoma has not been widely accepted as a standard therapy, however, because its effect on functional outcome has been regarded as marginal and there have been no randomized trials with sufficient statistical power to quantify the benefits of this procedure. The authors reassessed the value of stereotactic evacuation of hematoma by analyzing its impact on activities of living during th
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43

Khanevich, Mikhail, Georgiy Manikhas, Anton Khazov, and M. Kukanov. "BLOOD SUPPLY FEATURES OF SOFT TISSUE SARCOMAS OF THE EXTREMITIES." Problems in oncology 63, no. 5 (2017): 770–75. http://dx.doi.org/10.37469/0507-3758-2017-63-5-770-775.

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Surgical removal of tumor remains the only one radical treatment for patients with soft tissue sarcomas of the extremities. However, the parameters of total and disease-free survival after this type of treatment cannot be considered satisfactory. Currently the active search and introduction into clinical practice of additional impact methods that can improve the immediate and long-term results of treatment of such patients is being conducted. In the article there are presented results of the analysis of preoperative angiographic studies of 94 patients with primary and recurrent sarcomas of sof
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Bajec, Djordje, Dejan Radenkovic, Pavle Gregoric, et al. "Hirursko lecenje povreda jetre - petogodisnje iskustvo." Acta chirurgica Iugoslavica 57, no. 4 (2010): 9–14. http://dx.doi.org/10.2298/aci1004009b.

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Due to improved methods of treatment and management of hemorrhage, the mortality from liver injuries has decreased significantly over the past few decades. In spite of that, liver injuries still represent diagnostic and therapeutic challenge. This retrospective study included 197 patients surgically treated because of trauma of the liver at The Clinic for Emergency Surgery, during the period 2004-2009. The results showed significant difference in mortality rates in cases of penetrating wounds compared to blunt trauma and gunshot wounds. The severity of injury evaluated by Organ Injury Scale wa
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Paix, Bruce Richard, David John Tingey, Grant Copley, et al. "Prehospital External Aortic Compression for Temporizing Exsanguinating Sub-Diaphragmatic Hemorrhage – A Promising Technique, but with Challenges: Four Illustrative Cases, Including Two Survivors." Prehospital and Disaster Medicine 35, no. 1 (2020): 115–18. http://dx.doi.org/10.1017/s1049023x19005235.

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AbstractExternal aortic compression (EAC) has long been used to control exsanguinating post-partum hemorrhage, but it has only recently been described in the prehospital trauma setting. This paper reports four cases where manual EAC was used during transport to manage life-threatening bleeding, twice from stab wounds, once from ruptured ectopic pregnancy, and once from severe lower-limb trauma. It showed that EAC has life-saving potential in the prehospital setting, but that safety and efficacy during transport requires the use of a hands-free compression device, such as an aortic tourniquet.
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Thompson, Todd P., Douglas Kondziolka, and A. Leland Albright. "Thalamic stimulation for choreiform movement disorders in children." Journal of Neurosurgery 92, no. 4 (2000): 718–21. http://dx.doi.org/10.3171/jns.2000.92.4.0718.

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✓ Surgery for movement disorders is most commonly performed in patients with dyskinesia and tremor associated with Parkinson's disease or in those with essential tremor. The role of ablative surgery or deep brain stimulation in patients with choreiform movements is poorly defined.The authors placed thalamic stimulation systems in two children with disabling choreiform disorders due to intracerebral hemorrhage or cerebral palsy. Each patient displayed choreiform movements in the upper extremities both at rest and with intention, which interfered with daily activities and socialization. Both chi
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Spigariolo, Cristina B., Serena Giacalone, and Gianluca Nazzaro. "Pigmented Purpuric Dermatoses: A Complete Narrative Review." Journal of Clinical Medicine 10, no. 11 (2021): 2283. http://dx.doi.org/10.3390/jcm10112283.

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Pigmented purpuric dermatoses (PPD) include several skin diseases characterized by multiple petechial hemorrhage as consequence of capillaritis. PPD generally present with red to purple macules that progressively evolve to golden-brown color as the hemosiderin is reabsorbed. These lesions, often asymptomatic or associated with mild pruritus, usually occur on the lower extremities and may be a diagnostic and therapeutic challenge both for general practitioners and specialists in internal medicine or flebology. Clinical presentations include many subtypes that have been described over the years,
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Suwarba, I. Gusti Ngurah Made. "Anti-NMDAR encephalitis in 10-year-old girl." International journal of health sciences 5, no. 1 (2021): 1–8. http://dx.doi.org/10.29332/ijhs.v5n1.600.

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Anti-NMDAR encephalitis is a central nervous system (CNS) disease involving dysfunction of the autoimmune system. Anti-NMDAR encephalitis is an immune-mediated disease characterized by a complex neuropsychiatric syndrome and the presence of CSF antibodies against the GluN1 subunit of the NMDAR. The diagnosis was by history taking, physical examination, and antibody NMDAR for definitive diagnosis. Principal management is starting therapy earlier may lead to better outcomes. A 10-year-old girl was admitted to Sanglah Hospital, with a complaint of seizure with the characteristic of the seizure wa
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Mendelson, Janice A. "Topical Mafenide Hydrochloride Aqueous Spray in Initial Management of Massive Contaminated Wounds with Devitalized Tissue." Prehospital and Disaster Medicine 16, no. 3 (2001): 172–74. http://dx.doi.org/10.1017/s1049023x00025930.

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AbstractSince at least WWII, some open, contaminated wounds involving massive soft tissue injury and vascular damage have resulted in “irreversible shock,” despite prompt rescue, hemorrhage control, and blood and fluid replacement, without signs of clinical infection.In animal studies, survival time was related statistically to the dosage of Clostridium perfringens in multicontaminated explosive wounds. Survival time was lengthened by the application of some topical antibacterial agents, but actual recovery was achieved only with topical mafenide hydrochloride solution aqueous spray, which res
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50

Ramazanov, G. R., A. E. Talypov, A. A. Kanibolotskiy, et al. "Superior sagittal sinus thrombosis as a focal point of pulmonary embolism." Russian neurological journal 26, no. 1 (2021): 39–44. http://dx.doi.org/10.30629/2658-7947-2021-26-1-39-44.

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This article represents the discussion of a clinical case of superior sagittal sinus thrombosis as a focal point of fatal pulmonary embolism. Pulmonary embolism is a life-threatening condition, with a mortality rate of up to 40%. The direct source of pulmonary embolism is deep vein thrombosis of the lower extremities and pelvis in 80–90% of all cases. The veins of the upper extremities and venous heart cause it less often. Pulmonary embolism in patients with cerebral venous thrombosis is observed in 1.4% of patients.Cerebral venous thrombosis is a cerebrovascular disease manifested by venous o
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