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Journal articles on the topic 'Extrinsic Aging And Photoaging'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Asyi, Muhammad Shanan, Dedy Syahrizal, Nirwana Lazuardi Sary, and Fauzul Husna. "The Impact of Photoaging on Skin: A Systematic Review Analysis." Journal of Social Research 3, no. 1 (2023): 209–15. http://dx.doi.org/10.55324/josr.v3i1.1708.

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Aging of the skin is a complex biological process. The process of skin aging can be divided into two categories namely intrinsic and extrinsic aging. Intrinsic skin aging or natural aging is caused by changes in skin elasticity that occur with age. This type of aging cannot be prevented. While extrinsic skin aging is caused by environmental factors such as exposure to solar radiation (photoaging). In this study, the type of research approach used is a type of qualitative research through a literature review. The type of data used is the type of secondary data. Secondary data is a type of data

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Takemori, Kumiko, Ei Yamamoto, Takaaki Chikugo, Eri Shiratsuchi, and Takashi Kometani. "DPP-IV Inhibition by Solubilized Elastin Peptides from Yellowtail Bulbus Arteriosus Suppresses Ultraviolet-B-Induced Photoaging in Hairless Mice." Nutraceuticals 4, no. 4 (2024): 683–94. https://doi.org/10.3390/nutraceuticals4040038.

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Skin aging is intrinsic and extrinsic. Intrinsic, or chronological, skin aging is an inevitable process of chronological and physiological alterations. The factors contributing to extrinsic skin aging involve sunlight, nutrients, and stress. Thus, extrinsic aging is thought to be superimposed over intrinsic aging and depends on the intensity and duration of environmental exposure and skin type (e.g., dry skin, oily skin, or eczema). The most significant extrinsic aging factor is UV radiation, which causes cellular senescence in a process known as photoaging. This study aimed to illuminate the

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Trivedi, Madhvi, Rajesh Dutt Mehta, Bhikam Chand Ghiya, and Prasoon Soni. "Cutis Rhomboidalis Nuchae and Solar Lentigo with Squamous and Basal Cell Carcinoma – A Quartet of Chronic Sun Exposure." Journal of the Indian Academy of Geriatrics 20, no. 3 (2024): 161–63. http://dx.doi.org/10.4103/jiag.jiag_32_23.

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Abstract Aging is of two types, namely extrinsic and intrinsic aging. Extrinsic aging or photoaging is caused mainly due to damage caused by solar radiation. We report the case of a elderly male who presented with large growth on the scalp and ulcer on the face. However, on clinical examination, almost all the changes of photoaging, namely solar lentigo, cutis rhomboidalis nuchae squamous, and basal cell carcinoma were present. This case highlights the importance of thorough clinical examination needed in the geriatric population for the early diagnosis and timely management of their ailments.

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Wang, Vania, Yash Chhabra, Laura Hueser, Sneha Pramod, Alexis Carey, and Ashani Weeraratna. "Abstract 1274: Extrinsic photoaging vs intrinsic aging in dermal fibroblasts: Its impact on the microenvironment and melanoma progression." Cancer Research 83, no. 7_Supplement (2023): 1274. http://dx.doi.org/10.1158/1538-7445.am2023-1274.

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Abstract Melanoma is the deadliest form of skin cancer, with its incidence rising disproportionally to other cancers. Chronological aging is a major risk factor in all types of cancer as it has been shown to drive changes in noncancerous cells (stromal and immune) of the tumor microenvironment (TME) to promote tumor initiation and progression. Ultraviolet radiation (UVR) exposure, which is a major risk factor for melanoma, also can cause a physical premature aging phenotype, known as photoaging. Photoaging of the skin often occurs in tandem with chronological aging, and contributes to the phys

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Sanchez, Martina M., Thamidul Islam Tonmoy, B. Hyle Park, and Joshua T. Morgan. "Development of a Vascularized Human Skin Equivalent with Hypodermis for Photoaging Studies." Biomolecules 12, no. 12 (2022): 1828. http://dx.doi.org/10.3390/biom12121828.

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Photoaging is an important extrinsic aging factor leading to altered skin morphology and reduced function. Prior work has revealed a connection between photoaging and loss of subcutaneous fat. Currently, primary models for studying this are in vivo (human samples or animal models) or in vitro models, including human skin equivalents (HSEs). In vivo models are limited by accessibility and cost, while HSEs typically do not include a subcutaneous adipose component. To address this, we developed an “adipose-vascular” HSE (AVHSE) culture method, which includes both hypodermal adipose and vascular c

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Wang, Vania, Yash Chhabra, Laura Hueser, and Ashani Weeraratna. "Abstract 273: Extrinsic photoaging vs intrinsic aging in dermal fibroblasts: Its impact on the microenvironment and melanoma progression." Cancer Research 84, no. 6_Supplement (2024): 273. http://dx.doi.org/10.1158/1538-7445.am2024-273.

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Abstract Melanoma is the deadliest form of skin cancer, with chronological aging as a major negative prognostic factor due to the influence of intrinsic aging on the tumor microenvironment (TME) to promote tumor initiation and progression. Ultraviolet radiation (UVR) exposure, which is a major risk factor for melanoma, also can cause a physical premature aging phenotype, known as extrinsic photoaging, from chronic UVA irradiation of the underlying dermis. Photoaging of the skin often occurs in tandem with chronological aging, and contributes to similar physical alterations in normal skin struc

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7

Geng, Ruixuan, Seong-Gook Kang, Kunlun Huang, and Tao Tong. "Dietary Isoeugenol Supplementation Attenuates Chronic UVB-Induced Skin Photoaging and Modulates Gut Microbiota in Mice." Nutrients 16, no. 4 (2024): 481. http://dx.doi.org/10.3390/nu16040481.

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Photoaging, the primary cause of skin aging damage, results from chronic ultraviolet (UV) exposure, leading to dryness and wrinkle formation. Nutritional intervention has emerged as a practical approach for preventing and addressing the effect of skin photoaging. The primary aromatic compound isolated from clove oil, isoeugenol (IE), has antibacterial, anti-inflammatory, and antioxidant qualities that work to effectively restrict skin cancer cell proliferation. This investigation delved into the advantages of IE in alleviating skin photoaging using UVB-irradiated skin fibroblasts and female SK

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Sutikno, Lena Margaretha, I. Wayan Sugiritama, and I. Wayan Juli Sumadi. "Goji Berry (Lycium barbarum) Extract as a Potential Anti-Photoaging Agent: A Literature Review." Journal of Advances in Medical and Pharmaceutical Sciences 26, no. 12 (2024): 137–50. https://doi.org/10.9734/jamps/2024/v26i12739.

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Tropical countries worldwide are frequently subjected to high levels of sunlight year-round. This leads to concerns about potential harmful effects, including skin damage resulting from oxidative stress caused by free radicals due to prolonged sun exposure. This results in extrinsic skin aging, or photoaging. Sunscreen, as a primary photoprotection, is commonly recommended to protect the skin from sunlight. However, even sunscreens with high SPF cannot provide 100% protection from damage caused by free radicals generated by UV rays. Therefore, secondary photoprotection such as natural antioxid

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Zamarrón, Alicia, Esther Morel, Silvia Lucena, et al. "Extract of Deschampsia antarctica (EDA) Prevents Dermal Cell Damage Induced by UV Radiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin." International Journal of Molecular Sciences 20, no. 6 (2019): 1356. http://dx.doi.org/10.3390/ijms20061356.

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Exposure to natural and artificial light and environmental pollutants are the main factors that challenge skin homeostasis, promoting aging or even different forms of skin cancer through a variety of mechanisms that include accumulation of reactive oxygen species (ROS), engagement of DNA damage responses, and extracellular matrix (ECM) remodeling upon release of metalloproteases (MMPs). Ultraviolet A radiation is the predominant component of sunlight causative of photoaging, while ultraviolet B light is considered a potentiator of photoaging. In addition, different chemicals contribute to skin

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10

Tong, Tao, Ruixuan Geng, Seong-Gook Kang, Xiaomin Li, and Kunlun Huang. "Revitalizing Photoaging Skin through Eugenol in UVB-Exposed Hairless Mice: Mechanistic Insights from Integrated Multi-Omics." Antioxidants 13, no. 2 (2024): 168. http://dx.doi.org/10.3390/antiox13020168.

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Chronic ultraviolet (UV) exposure causes photoaging, which is primarily responsible for skin damage. Nutritional intervention is a viable strategy for preventing and treating skin photoaging. Eugenol (EU) presents anti-inflammatory and antioxidant properties, promotes wound healing, and provides contact dermatitis relief. This study explored the ability of EU to mitigate skin photoaging caused by UVB exposure in vitro and in vivo. EU alleviated UVB-induced skin photodamage in skin cells, including oxidative stress damage and extracellular matrix (ECM) decline. Dietary EU alleviated skin photoa

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Lee, Sullim, Jae Sik Yu, Hung Manh Phung, Jeong Gun Lee, Ki Hyun Kim та Ki Sung Kang. "Potential Anti-Skin Aging Effect of (-)-Catechin Isolated from the Root Bark of Ulmus davidiana var. japonica in Tumor Necrosis Factor-α-Stimulated Normal Human Dermal Fibroblasts". Antioxidants 9, № 10 (2020): 981. http://dx.doi.org/10.3390/antiox9100981.

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Reactive oxygen species (ROS) are generated during skin aging, including intrinsic (chronologic aging) and extrinsic aging (photoaging). Therefore, antioxidants that inhibit ROS generation can delay skin aging. In this study, we evaluated the potential anti-skin aging effect of (-)-phenolic compounds isolated from the root bark of Ulmus davidiana var. japonica. We preferentially investigated the possible preventive effects of isolates against the degradation of skin extracellular matrix. Among the isolates, (-)-catechin suppressed the activity of collagenase MMP-1, and reversed the degradation

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12

Ardhaninggar, Agatha Anindhita, Dwi Murtiastutik, Sawitri Sawitri, and Cita Rosita Sigit Prakoeswa. "The Efficacy of Topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging." Berkala Ilmu Kesehatan Kulit dan Kelamin 32, no. 2 (2020): 126. http://dx.doi.org/10.20473/bikk.v32.2.2020.126-133.

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Background: Photoaging, also called extrinsic aging, is a premature skin aging mainly resulting from prolonged and extended exposure to ultraviolet (UV) radiation. Amniotic Membrane Stem Cell Metabolite Products (AMSC-MP) are derived from amniotic membranes that contain cytokines and growth factors that have a role in the skin rejuvenation process. Vitamin E is an antioxidant that has a photoprotective effect, so it is expected to reduce the appearance of clinical signs of photoaging. Not only having skin rejuvenation effect, but microneedling is also expected to facilitate the penetration to

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13

Marchlewicz, Mariola, Justyna Wojnarowicz, Aleksandra Wilk, et al. "Effect of Helix aspersa Mucus on the Regeneration of Skin with Photoaging Features in Different Methods of Application." Applied Sciences 14, no. 16 (2024): 7394. http://dx.doi.org/10.3390/app14167394.

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Skin aging is associated with both intrinsic and extrinsic aging, with extrinsic aging caused by environmental factors and overlaying the effects of chronological aging. The main aim of this study was to evaluate the effect of preparations containing Helix aspersa snail mucus on skin regeneration with photoaging features. Before and 3 months after the series of treatments, skin biopsy specimens from the right preauricular region of the face were taken from six women. Histological, morphometric, and immunohistochemical analyses were performed. Positive changes, indicating a reduction in photoag

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14

Lee, Jin-Sung, Jin-Woo Min, Seong-Bong Gye, et al. "Suppression of UVB-Induced MMP-1 Expression in Human Skin Fibroblasts Using Lysate of Lactobacillus iners Derived from Korean Women’s Skin in Their Twenties." Current Issues in Molecular Biology 46, no. 1 (2024): 513–26. http://dx.doi.org/10.3390/cimb46010033.

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The process of skin aging is intricate, involving intrinsic aging, influenced by internal factors, and extrinsic aging, mainly caused by exposure to UV radiation, resulting in photoaging. Photoaging manifests as skin issues such as wrinkles and discoloration. The skin microbiome, a diverse community of microorganisms on the skin’s surface, plays a crucial role in skin protection and can be affected by factors like humidity and pH. Probiotics, beneficial microorganisms, have been investigated for their potential to enhance skin health by regulating the skin microbiome. This can be accomplished

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15

Xue, Nina, Ying Liu, Jing Jin, Ming Ji, and Xiaoguang Chen. "Chlorogenic Acid Prevents UVA-Induced Skin Photoaging through Regulating Collagen Metabolism and Apoptosis in Human Dermal Fibroblasts." International Journal of Molecular Sciences 23, no. 13 (2022): 6941. http://dx.doi.org/10.3390/ijms23136941.

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Skin aging is categorized as chronological aging and photo-aging that affected by intrinsic and extrinsic factors. The present study aimed to investigate the anti-aging ability and its underlying mechanism of chlorogenic acid (CGA) on human dermal fibroblasts (HDFs). In this study, CGA specifically up-regulated collagen I (Col1) mRNA and protein expressions and increased the collagen secretion in the supernatant of HDFs without affecting the cell viability, the latter was also demonstrated in BioMAP HDF3CGF system. Under ultraviolet A (UVA)-induced photoaging, CGA regulated collagen metabolism

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16

Pourzand, Charareh, Andrea Albieri-Borges, and Nico N. Raczek. "Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants." Antioxidants 11, no. 3 (2022): 471. http://dx.doi.org/10.3390/antiox11030471.

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Reactive oxygen species (ROS) are necessary for normal cell signaling and the antimicrobial defense of the skin. However excess production of ROS can disrupt the cellular redox balance and overwhelm the cellular antioxidant (AO) capacity, leading to oxidative stress. In the skin, oxidative stress plays a key role in driving both extrinsic and intrinsic aging. Sunlight exposure has also been a major contributor to extrinsic photoaging of the skin as its oxidising components disrupt both redox- and iron-homeostasis, promoting oxidative damage to skin cells and tissue constituents. Upon oxidative

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17

Abdul, Kader Mohiuddin. "Skin Aging & Modern Age Anti-aging Strategies." Global Journal of Medical Research: B Pharma, Drug Discovery, Toxicology & Medicine 19, no. 2 (2019): 14–60. https://doi.org/10.5281/zenodo.3547398.

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As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain num

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18

Park, Jeong-Yong, Ji Yeon Lee, Seonghwa Hong, et al. "Limosilactobacillus fermentum MG5368 and Lactiplantibacillus plantarum MG989 Regulates Skin Health in UVB-Induced HaCaT Cells and Hairless Mice Model." Nutrients 16, no. 23 (2024): 4083. http://dx.doi.org/10.3390/nu16234083.

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Background: Photoaging, induced by chronic ultraviolet B (UVB) exposure, results in the degradation of extracellular matrix (ECM) components, leading to skin roughness, wrinkle formation, and reduced elasticity. Recent studies have explored probiotics as potential inhibitors of extrinsic aging, primarily through mechanisms that protect the skin barrier and reduce collagen breakdown. Methods: This study investigates the anti-photoaging effects of Limosilactobacillus fermentum MG5368 (L. fermentum MG5368) and Lactiplantibacillus plantarum MG989 (L. plantarum MG989) in UVB-exposed keratinocytes a

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19

D’Arino, Andrea, Silvia Caputo, Laura Eibenschutz, et al. "Skin Cancer Microenvironment: What We Can Learn from Skin Aging?" International Journal of Molecular Sciences 24, no. 18 (2023): 14043. http://dx.doi.org/10.3390/ijms241814043.

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Aging is a natural intrinsic process associated with the loss of fibrous tissue, a slower cell turnover, and a reduction in immune system competence. In the skin, the continuous exposition of environmental factors superimposes extrinsic damage, mainly due to ultraviolet radiation causing photoaging. Although not usually considered a pathogenic event, photoaging affects cutaneous biology, increasing the risk of skin carcinogenesis. At the cellular level, aging is typified by the rise of senescence cells a condition characterized by reduced or absent capacity to proliferate and aberrant hyper-se

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20

Oh, Jung Hwan, Fatih Karadeniz, Jung Im Lee, So Young Park, Youngwan Seo та Chang-Suk Kong. "Anticatabolic and Anti-Inflammatory Effects of Myricetin 3-O-β-d-Galactopyranoside in UVA-Irradiated Dermal Cells via Repression of MAPK/AP-1 and Activation of TGFβ/Smad". Molecules 25, № 6 (2020): 1331. http://dx.doi.org/10.3390/molecules25061331.

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UV irradiation is one of the main causes of extrinsic skin aging. UV-mediated skin aging, also known as photoaging, causes excessive breakdown of extracellular matrix which leads skin to lose its elasticity and strength. Several phytochemicals are known to exert anti-photoaging effects via different mechanisms, partly due to their antioxidant properties. The current study has been carried out to determine the potential anti-photoaging properties of myricetin 3-O-β-d-galacto-pyranoside (M3G), a flavonol glycoside isolated from L. tetragonum, in UVA-irradiated in vitro models; HaCaT keratinocyte

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21

Abdul, Kader Mohiuddin. "Urbanization, Environmental Pollution & Skin Aging." American Research Journal of Dermatology 1, no. 1 (2019): 1–9. https://doi.org/10.21694/2642-2980.19007.

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The skin aging process, which is induced by environmental factors, is named premature or extrinsic skin aging process and can be distinguished from the chronologically (intrinsic) skin aging process by characteristic skin aging signs. Although human skin acts as a biological shield against pro-oxidative chemicals and physical air pollutants, prolonged or repetitive exposure to high levels of these pollutants may have profound negative effects on the skin. Gender differences in toxicity have been reported for many substances. Children are known to be more vulnerable to the adverse health effect

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Wikassa, Tasya, Damayanti Damayanti, Irfiansyah Irwadi, et al. "Skin Aging Profile in Tertiary Hospital: a Descriptive Study." Berkala Ilmu Kesehatan Kulit dan Kelamin 34, no. 1 (2022): 36–45. http://dx.doi.org/10.20473/bikk.v34.1.2022.36-45.

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Background: Skin aging is a physiological process that involves changes in skin cells and tissues due to abnormal mechanisms and decreased tissue function caused by both intrinsic and extrinsic factors. Skin aging has different clinical manifestations in each individual, which were classified using Glogau's photoaging classification. Purpose: The objective of this descriptive observational study is to evaluate the profile of skin aging patients at Dr. Soetomo General Hospital Surabaya from January – December 2019. Methods: This study utilized a total sampling technique from data obtained from

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Luchowska, Anna, Monika Sroczyńska, and Aleksandra Żaczek. "Acne medication as a potential solution for slowing down the aging process – a systematic review." Journal of Education, Health and Sport 13, no. 2 (2022): 172–76. http://dx.doi.org/10.12775/jehs.2023.13.02.024.

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Introduction One of the major challenges of the 21st century is the fight against aging. There are two main processes that induce skin aging: intrinsic and extrinsic, with sun exposure being the most damaging to the skin. A number of drugs have been used to prevent aging changes. It has been proposed that low dose oral isotretinoin could be administered as a safe and effective treatment for skin that has undergone photoaging changes. Aim of the study The aim of the study was to examine the potential efficacy of low dose oral isotretinoin in the antiaging therapy. Materials and methods A search

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Susanto, Ester Chateline, Trisniartami Setyaningrum, Arifa Mustika, and Linda Astari. "Chemical Peeling in Skin-Aging Patients: A Retrospective Study." Berkala Ilmu Kesehatan Kulit dan Kelamin 35, no. 1 (2023): 6–14. http://dx.doi.org/10.20473/bikk.v35.1.2023.6-14.

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Background: Skin aging is a degenerative process that involves a decrease in the structure and function of skin cells and theextracellular matrix due to intrinsic and extrinsic factors. Chemical peeling is one of the skin aging treatments that involvesskin ablation using chemical agents. Purpose: To evaluate the profile of skin-aging patients treated with chemical peeling atthe Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Hospital Surabaya from January throughDecember 2019. Methods: The data were obtained from patients’ medical records through a total sampling technique,

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Davinelli, Sergio, Juan Carlos Bertoglio, Ascanio Polimeni, and Giovanni Scapagnini. "Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage." Current Pharmaceutical Design 24, no. 2 (2018): 99–105. http://dx.doi.org/10.2174/1381612823666171109102426.

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Background: Skin aging is a complex biological process influenced by a combination of intrinsic and extrinsic factors, leading to cumulative alterations of skin structure, function and appearance. Polyphenols, which are secondary plant metabolites, represent one of the largest classes of compounds used in dermatology and nutricosmetics to combat skin aging. The main objective is to provide an overview of the existing literature linking skin aging and the ability of polyphenols as regulatory elements able to maintain skin homeostasis. Methods: In this review, we discuss recent progress in under

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26

Carmo, Gregória Keyla Santos Do, Inaeh Grazylele Paz Amorim, Sildiane Primo Dos Santos, and Bernardo Melo Neto. "IMPORTÂNCIA DOS CUIDADOS COM A PELE NO PROCESSO CONTRA O FOTOENVELHECIMENTO." Revista ft 29, no. 146 (2025): 35–36. https://doi.org/10.69849/revistaft/ar10202505101535.

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Introduction: Ultraviolet (UV) radiation is the main environmental factor that affects skin wear, where photoaging is the result of the effects of solar radiation together with chronological aging of the skin and under these conditions, skin functions that are already compromised can be further affected. The use of photoprotectors and access to information on sun exposure are extremely important to avoid damage to the skin. Objectives: To evaluate the importance of skin care in preventing extrinsic aging, thus contributing to dermatological health and long-term well-being. Methodology: This re

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Jung, JaeIn, Yean-Jung Choi, JinHee Yoo, Su-Young Choi, and EunJi Kim. "Antiphotoaging Effect of AGEs Blocker™ in UVB-Irradiated Cells and Skh:HR-1 Hairless Mice." Current Issues in Molecular Biology 45, no. 5 (2023): 4181–99. http://dx.doi.org/10.3390/cimb45050266.

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Chronic exposure to ultraviolet (UV) radiation is a major cause of photoaging. It involves extrinsic aging, wrinkle formation, and skin dehydration, and leads to excessive production of active oxygen that adversely affects the skin. Here, we investigated the antiphotoaging effect of AGEs BlockerTM (AB), which comprises Korean mint aerial part and fig and goji berry fruits. Compared to its individual components, AB was more potent at increasing the expression of collagen and hyaluronic acid and decreasing MMP-1 expression in UVB-irradiated Hs68 fibroblasts and HaCaT keratinocytes. In Skh:HR-1 h

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Al Hamid, Muhammad, Cut Elvira Novita, Johanna Fransiska Wijaya, and Djamin Djamin. "Effect of gotu kola leaf extract cream on collagenization and histopathological picture of rat skin exposed to Ultraviolet B light." Jurnal Prima Medika Sains 6, no. 2 (2024): 169–76. https://doi.org/10.34012/jpms.v6i2.5743.

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Changes due to genetic conditions (internal and chronological aging) overlap with aging symptoms triggered by environmental conditions (extrinsic aging). Until recently, exposure to the sun's ultraviolet (UV) radiation was considered the leading cause of extrinsic skin aging; both UVB (290-320 nm) and UVA (320-400 nm) caused photoaging, and due to their physical properties, UVB radiation was especially harmful to the skin condition. This study aims to analyze and test the effect of administering gotu kola leaf extract cream (Ceentella asiatica) on collagenization in Wistar rats (Rattus norvegi

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Letsiou, Sophia, Maria Trapali, Despina Vougiouklaki, Aliki Tsakni, Dionysis Antonopoulos, and Dimitra Houhoula. "Antioxidant Profile of Origanum dictamnus L. Exhibits Antiaging Properties against UVA Irradiation." Cosmetics 10, no. 5 (2023): 124. http://dx.doi.org/10.3390/cosmetics10050124.

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Skin aging mainly occurs due to intrinsic and extrinsic factors. Extrinsic aging is a consequence of exposure to ultraviolet radiation. Meanwhile, natural products exhibit protective properties against skin aging as well as photoaging. In this context, the research on natural anti-aging agents is greatly advanced, and in recent years, numerous plant-based products have been investigated. The aim of this study was to assess the antioxidant profile of Origanum dictamnus L. extract as well as its antiaging effects on 2D cultures of fibroblasts and keratinocytes under UVA irradiation to unravel th

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Bar, Ofek, and Skaidra Valiukevičienė. "Skin Aging and Type I Collagen: A Systematic Review of Interventions with Potential Collagen-Related Effects." Cosmetics 12, no. 4 (2025): 129. https://doi.org/10.3390/cosmetics12040129.

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Aging leads to a decline in skin function due to intrinsic factors (genetics, hormones) and extrinsic factors (sun exposure, pollutants). Type I collagen plays a vital role in maintaining skin integrity and elasticity. As aging progresses, collagen synthesis diminishes, resulting in weakened skin structure and wrinkle formation. This systematic review explores the role of type I collagen in skin aging by summarizing key clinical findings. A systematic search was conducted using PubMed and ScienceDirect as the primary databases, including studies published between 2014 and 2025 that addressed t

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Hwang, Eunson, Hien T. T. Ngo, Bom Park, Seul-A. Seo, Jung-Eun Yang, and Tae-Hoo Yi. "Myrcene, an Aromatic Volatile Compound, Ameliorates Human Skin Extrinsic Aging via Regulation of MMPs Production." American Journal of Chinese Medicine 45, no. 05 (2017): 1113–24. http://dx.doi.org/10.1142/s0192415x17500604.

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Myrcene is an aromatic volatile compound that is commercially well-known as a flavor ingredient in the food industry and a fragrance in the soap and detergent industry. Given the worldwide interest in natural antiphotoaging products, we investigated the protective effects of myrcene in UVB-irradiated human dermal fibroblasts (NHDFs). NHDFs were subjected to 144[Formula: see text]mJ/cm2of UVB irradiation. The expression of intracellular reactive oxygen species (ROS), matrix metalloproteinase-1 (MMP-1), MMP-3, interleukin-6 (IL-6), transforming growth factor (TGF-[Formula: see text]1) and type I

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Shanbhag, Shreya, Akshatha Nayak, Reema Narayan, and Usha Yogendra Nayak. "Anti-aging and Sunscreens: Paradigm Shift in Cosmetics." Advanced Pharmaceutical Bulletin 9, no. 3 (2019): 348–59. http://dx.doi.org/10.15171/apb.2019.042.

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Skin, being one of the vital organs and a protective barrier needs to be pampered and taken care of from early childhood. It is the most visible and the widest exposed organ and by far reflects the general health condition and the aging process in humans. Both intrinsic and extrinsic factors contribute to this complex biological process of skin aging. In recent times, skin health and its beauty is perceived as an indicator of one’s health which has resulted in an increasing demand for anti-aging products. Exposure to UV radiation is considered to be one of the factors responsible for aging ter

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Avagumyan, Maria Armaisovna, Larisa Sergeevna Kruglova, and Evgenia Vladimirovna Ikonnikova. "Combined application of microneedling and laser therapy in the correction of involutive changes." Fizioterapevt (Physiotherapist), no. 2 (March 25, 2022): 51–59. http://dx.doi.org/10.33920/med-14-2204-06.

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The relevance of research. In the XX–XXI centuries, the average life expectancy has increased significantly and the issues of not only maintaining health, but also the appearance have acquired social significance. The aging of the skin as an organ is different as it combines intrinsic aging and extrinsic aging, which is limited to environmentally exposed skin such as the face, back of the hands and neck. Therefore, the development of new methods for correcting involutive changes, taking into account the clinical symptoms of natural aging and photodamage, is relevant. Material and methods. Unde

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Pabuprapap, Wachirachai, Wongnapa Nakyai, Waraluck Chaichompoo, et al. "Curcuma aromatica and Curcuma comosa Extracts and Isolated Constituents Provide Protection against UVB-Induced Damage and Attenuate Matrix Metalloproteinase-1 Expression in HaCaT Cells." Cosmetics 9, no. 1 (2022): 23. http://dx.doi.org/10.3390/cosmetics9010023.

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Ultraviolet-B (UVB) exposure is one of the primary extrinsic factors causing skin photoaging. It stimulates inflammatory responses and arrests the cell cycle. Matrix metalloproteinase-1 (MMP-1) secreted by keratinocytes is one of the important extracellular matrixes to attenuate UVB-induced skin aging via collagen degradation. Curcuma aromatica (CA) and Curcuma comosa (CC), the herbaceous plants in the Zingiberaceae family, are commonly used in Thai traditional women’s medicines. The present work was aimed to investigate the potential of the CA and CC extracts and their isolated compounds to a

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Nadia Hidayati, Noor Aulia Hatikhah, Winawati Eka Putri, et al. "The effect of long exposure to uvb rays on histological features of wistar rats (Rattus norvegicus) in photoaging model." Bali Medical Journal 12, no. 3 (2023): 3078–83. http://dx.doi.org/10.15562/bmj.v12i3.4393.

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Introduction: Indonesia is a tropical country with exposure to UV rays from the sun throughout the year, so the Indonesian population is very vulnerable to skin aging, especially extrinsic skin aging due to prolonged exposure to UV rays. This study aimed to determine the effect of long exposure to UVB rays on the thickness of the epidermis, the thickness of the dermis, and the number of blood vessels and sunburn cells in (Rattus norvegicus) Wistar strain. Methods: This research was a post-test-only control group design using 27 rats which were divided into 3 groups, namely: control group K was

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Bighetti, Stefano, Chiara Rovati, Luca Bettolini, et al. "Two-Photon Microscopy for the Investigation of Morphological and Quantitative Changes in Skin Chrono- and Photo-Aging." Cosmetics 12, no. 3 (2025): 111. https://doi.org/10.3390/cosmetics12030111.

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Introduction: Skin aging is influenced both by intrinsic factors and environmental exposures, such as UV radiation, which accelerate structural changes within the skin’s extracellular matrix (ECM). Understanding these changes is crucial for developing effective anti-aging treatments. Materials and Methods: This pilot cross-sectional study examined skin biopsy samples from three Caucasian male subjects with different levels of UV exposure, aiming to evaluate the effectiveness of two-photon microscopy (2PM) and Second Harmonic Generation (SHG) in visualizing and quantifying structural changes as

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Djawad, Khairuddin. "The effectiveness of Oral Superoxide Dismutase (SOD) on total antioxidant status, Trans Epidermal Water Loss (TEWL) and sebum concentration in photo aging skin." Research, Society and Development 10, no. 1 (2021): e32410111402. http://dx.doi.org/10.33448/rsd-v10i1.11402.

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Introduction: Aging is a progressive process of decrease in organs functions and capacity, including the skin. Photoaging is extrinsic aging mainly occur due to ultraviolet (UV) exposure. Methods: This study is a clinical trial research design with one group pre-post test. All subjects who were exposed to UV for approximately 3-4 hours. All subjects signed an informed consent and were interviewed accordingly. Photoaging was diagnosed clinically by three dermatologists according to Glogau type II classification such as dynamic wrinkles, palpable keratosis, visible lentigo senilis, and smiley li

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Djawad, Khairuddin, and Dewi Anggraini. "THE EFFECTIVENESS OF ORAL SUPEROXIDE DISMUTASE (SOD) ON TOTAL ANTIOXIDANT STATUS, TRANSEPIDERMAL WATER LOSS (TEWL) AND SEBUM CONCENTRATION IN PHOTO AGING SKIN." Medical Science of Ukraine (MSU) 17, no. 1 (2021): 47–56. http://dx.doi.org/10.32345/2664-4738.1.2021.06.

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Relevance. Aging is a progressive process of decrease in organs functions and capacity, including the skin. Photoaging is extrinsic aging mainly occurs due to ultraviolet (UV) exposure. The effectiveness of oral SOD for premature aging is still not yet known. Objective: We aimed to evaluate the effectiveness of this antioxidant on total antioxidant status (TAS), skin hydration (TEWL), and sebum concentration in premature skin aging. Methods. This study is a clinical trial research design with one group pre-post test. All subjects were exposed to UV for approximately 3-4 hours. All

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Lee, Sullim, Taesu Jang, Ki Hyun Kim, and Ki Sung Kang. "Improvement of Damage in Human Dermal Fibroblasts by 3,5,7-Trimethoxyflavone from Black Ginger (Kaempferia parviflora)." Antioxidants 11, no. 2 (2022): 425. http://dx.doi.org/10.3390/antiox11020425.

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Reactive oxygen species (ROS) are generated during intrinsic (chronological aging) and extrinsic (photoaging) skin aging. Therefore, antioxidants that inhibit ROS production may be involved in delaying skin aging. In this study, we investigated the potential effects of compounds isolated from black ginger, Kaempferia parviflora, a traditional medicinal plant, on normal human dermal fibroblasts in the context of inflammation and oxidative stress. The isolated compounds were structurally characterized as 5-hydroxy-7-methoxyflavone (1), 3,7-dimethoxy-5-hydroxyflavone (2), 5-hydroxy-3,7,3,4-tetram

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Jo, Chan Song, Cheol Hwan Myung, Yeo Cho Yoon, et al. "The Effect of Lactobacillus plantarum Extracellular Vesicles from Korean Women in Their 20s on Skin Aging." Current Issues in Molecular Biology 44, no. 2 (2022): 526–40. http://dx.doi.org/10.3390/cimb44020036.

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Extracellular vesicles, which are highly conserved in most cells, contain biologically active substances. The vesicles and substances interact with cells and impact physiological mechanisms. The skin is the most external organ and is in direct contact with the external environment. Photoaging and skin damage are caused by extrinsic factors. The formation of wrinkles is a major indicator of skin aging and is caused by a decrease in collagen and hyaluronic acid. MMP-1 expression is also increased. Due to accruing damage, skin aging reduces the ability of the skin barrier, thereby lowering the sk

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Prasanth, Mani, Bhagavathi Sivamaruthi, Chaiyavat Chaiyasut, and Tewin Tencomnao. "A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy." Nutrients 11, no. 2 (2019): 474. http://dx.doi.org/10.3390/nu11020474.

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Tea is one of the most widely consumed beverages worldwide, and is available in various forms. Green tea is richer in antioxidants compared to other forms of tea. Tea is composed of polyphenols, caffeine, minerals, and trace amounts of vitamins, amino acids, and carbohydrates. The composition of the tea varies depending on the fermentation process employed to produce it. The phytochemicals present in green tea are known to stimulate the central nervous system and maintain overall health in humans. Skin aging is a complex process mediated by intrinsic factors such as senescence, along with extr

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Anitha, S. "A clinical study of geriatric dermatoses in Dharmapuri district, Tamil Nadu, India." International Journal of Research in Dermatology 6, no. 4 (2020): 479. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20202651.

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<p class="abstract"><strong>Background:</strong> Geriatric dermatoses are one of the most common reasons for day-to-day consultation in the elderly. Over the past few years, understanding of the pathophysiology of skin changes in the geriatric age group has improved and has paved the way for better therapeutic options. This article reviews the various physiological and pathological changes of aging, dwelling on the role of intrinsic and extrinsic factors in the pathogenesis of aging skin. To describe the clinical pattern of various dermatological disorders in the elderly.<

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Pambianchi, Erika, Zachary Hagenberg, Alessandra Pecorelli, et al. "Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage." Cosmetics 8, no. 4 (2021): 112. http://dx.doi.org/10.3390/cosmetics8040112.

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Our body is continuously exposed to various exogenous aggressors, and, in particular, the skin represents the main target for outdoor stressors, including ultraviolet (UV) radiation. UV exposure is well-known to be associated with the development/worsening of extrinsic photoaging and a multitude of skin conditions. Considering the role of photoprotection in skin health, the research of natural photoprotective molecules becomes of great importance. Therefore, in this work we wanted to evaluate the beneficial protective effects of ripe berries of Vaccinium uliginosum (Alaska bog blueberry (BB))

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Kim, Kang Sub, Yea Jung Choi, Dae Sik Jang та Sullim Lee. "2-O-β-d-Glucopyranosyl-4,6-dihydroxybenzaldehyde Isolated from Morus alba (Mulberry) Fruits Suppresses Damage by Regulating Oxidative and Inflammatory Responses in TNF-α-Induced Human Dermal Fibroblasts". International Journal of Molecular Sciences 23, № 23 (2022): 14802. http://dx.doi.org/10.3390/ijms232314802.

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Human skin is composed of three layers, of which the dermis is composed of an extracellular matrix (ECM) comprising collagen, elastin, and other proteins. These proteins are reduced due to skin aging caused by intrinsic and extrinsic factors. Among various internal and external factors related to aging, ultraviolet (UV) radiation is the main cause of photoaging of the skin. UV radiation stimulates DNA damage, reactive oxygen species (ROS) generation, and pro-inflammatory cytokine production such as tumor necrosis factor-alpha (TNF-α), and promotes ECM degradation. Stimulation with ROS and TNF-

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Octavia, Chitra, Julia Windi Gunadi, Oeij Anindita Adhika, et al. "The effect of saffron serum on collagen density, inflammatory gene expression, and autophagy in UVB-exposed Wistar rats." Universa Medicina 43, no. 3 (2024): 329–39. https://doi.org/10.18051/univmed.2024.v43.329-339.

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BackgroundSkin aging is a complex biological phenomenon influenced by intrinsic and extrinsic factors. Photoaging can be prevented by applying phytochemicals that have sun-protective properties. This study aimed to evaluate the effect of saffron serum to restore collagen density and autophagy processes and reduce inflammatory gene expression in UVB-exposed Wistar rats. MethodsAn experimental laboratory study was conducted involving 20 male Wistar rats that were divided into 4 groups: control, UVB, UVB + base serum, UVB + saffron serum exposed to UVB radiation for 5 weeks with a total dose of 3

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Qarani, Waisul, Fauzul Husna, Winda Yulia, et al. "Antioxidant and antiaging activity of Cinnamomum burmannii and Michelia champaca extract and combinations." Narra J 3, no. 2 (2023): e111. http://dx.doi.org/10.52225/narra.v3i2.111.

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Aging is a natural skin process that occurs due to intrinsic and extrinsic factors, such as excessive exposure to ultraviolet light (photoaging). The mechanism of damage involves the production of excess free radicals that trigger oxidative stress in the skin. Determining the natural products that have high antioxidant activities as antiaging is up most important. Cinnamomum burmannii and Michelia champaca are typical Aceh plants that are believed to have high antioxidant effects. The aim of this study was to determining the contents of C. burmannii and M. champaca as well as to determine the

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LUCHOWSKA, Anna, Monika SROCZYŃSKA, and Aleksandra ŻACZEK. "Acne medication as a potential solution for slowing down the aging process – a systematic review." Journal of Education, Health and Sport 13, no. 2 (2022): 172–76. https://doi.org/10.12775/JEHS.2023.13.02.024.

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<strong>LUCHOWSKA, Anna, SROCZYŃSKA, Monika & ŻACZEK, Aleksandra. Acne medication as a potential solution for slowing down the aging process – a systematic review</strong><strong>. Journal of Education, Health and Sport. 2023;13(2):1</strong><strong>72</strong><strong>-1</strong><strong>76</strong><strong>. eISSN 2391-8306. DOI </strong><strong>https://dx.doi.org/10.12775/JEHS.2023.13.02.02</strong><strong>4</strong> <strong>https://apcz.umk.pl/JEHS/article/view/41</strong><strong>331</strong> <strong>https://zenodo.org/record/7489796</strong>           <stro

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Chung, Jin Ho, Valerie N. Hanft, and Sewon Kang. "Aging and photoaging." Journal of the American Academy of Dermatology 49, no. 4 (2003): 690–97. http://dx.doi.org/10.1067/s0190-9622(03)02127-3.

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Jeayeng, Saowanee, Jirapan Thongsroy, and Sirithip Chuaijit. "Caenorhabditis elegans as a Model to Study Aging and Photoaging." Biomolecules 14, no. 10 (2024): 1235. http://dx.doi.org/10.3390/biom14101235.

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Caenorhabditis elegans (C. elegans) has emerged as an outstanding model organism for investigating the aging process due to its shortened lifespan, well-defined genome, and accessibility of potent genetic tools. This review presents the current findings on chronological aging and photoaging in C. elegans, exploring the elaborate molecular pathways that control these processes. The progression of chronological aging is characterized by a gradual deterioration of physiological functions and is influenced by an interaction of genetic and environmental factors, including the insulin/insulin-like s

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Wang, Chu, Zhiyong Yan, Muhan Liu, and Lu Liu. "Photo-Aging of Biodegradable Polylactic Acid Microplastics." E3S Web of Conferences 598 (2024): 01001. http://dx.doi.org/10.1051/e3sconf/202459801001.

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Microplastic (MPs) pollution has became a serious issue. Photoaging is one of the main ways to produce MPs. Polylactic acid (PLA) is the most commonly used biodegradable plastic in industry, however, the current reports on the quantitative data of biodegradable PLA MPs produced by photoaging were little known. Therefore, this study selected PLA MPs as representative MPs to explore photoaging of biodegradable MPs. The results showed that PLA MPs were broken by photoaging, resulting in an increase in the total particle numbers and a decrease in average particle size. The numbers of particle in P

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