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Journal articles on the topic 'Extrusion-spheronization'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Jain, Satishkumar P., Pirthi Pal Singh, and Purnima D. Amin. "Alternative extrusion–spheronization aids." Drug Development and Industrial Pharmacy 36, no. 11 (June 3, 2010): 1364–76. http://dx.doi.org/10.3109/03639045.2010.482590.

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2

Zhang, Rui Shi, J. Z. Pan, and L. W. Wang. "Manufacture of Fine AL₂O₃Granules as Catalyst Carrier by an Extrusion/Spheronization Method." Advanced Materials Research 44-46 (June 2008): 361–66. http://dx.doi.org/10.4028/www.scientific.net/amr.44-46.361.

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The effect of formulation (filler’s kind and amount, liquid’s kind and concentration required for granulation) and spheronization time on characterization of alumina based pellets parameters (pellets size distribution, roundness and aspect ratio) were investigated. Two schemes were successfully proofed by extrusion/spheronization. The mean volume particle diameter was found to have a profound effect on the formulation and processing parameters. Alumina powder with large mean volume particle diameter showed different mechanism of action with coupling agent. With the surface modification, the water required for granulation had decreased. The existing formal and kinematic velocity of the water had a direct effect on the processing parameter of the extrusion and spheronization. Spheronization time from 2 to 10 min had a pronounced effect on roundness and aspect ratio. No changes in roundness and aspect ratio were observed from 10 to 20 min of spheronization time.

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3

Santoso, Rahmat, and Fiqi Aliudin. "KAJIAN PUSTAKA FORMULASI DAN EVALUASI MIKROKAPSUL SALUT ENTERIK MENGGUNAKAN ACRYL-EZE® & SURETERIC DENGAN METODE PENGGABUNGAN MIKROENKAPSULASI DENGAN EKSTRUSI-SFERONISASI." Jurnal Riset Kefarmasian Indonesia 2, no. 3 (September 15, 2020): 122–36. http://dx.doi.org/10.33759/jrki.v2i3.89.

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Microcapsules were prepared by means of microencapsulation modified by the extrusion-spheronization method. The extrusion-spheronization method is used to cover the shortcomings of the microencapsulation method. The results showed that Acryl-eze and Sureterik can be used in coatings in producing microcapsules. The results of research evaluating the formulation of enteric acetosal coated microcapsules have not resulted in delayed release system that is in accordance with monographic requirements and dissolution profile testing has not shown the elimination stage. The results of the evaluation of the delayed release release system enteric coated microcapsule formulation met the requirements of monograph and dissolution profile test results, except for F3 in buffering conditions. The purpose of this literature review is to examine the enteric-coated microcapsule formulation using Acryl-eze® & Sureteric by combining microencapsulation and spheronization extrusion methods.

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4

Sinha, Vivek Ranjan, M. K. Agrawal, A. Agarwal, Gurpreet Singh, and D. Ghai. "Extrusion-Spheronization: Process Variables and Characterization." Critical Reviews in Therapeutic Drug Carrier Systems 26, no. 3 (2009): 275–331. http://dx.doi.org/10.1615/critrevtherdrugcarriersyst.v26.i3.20.

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5

GOSKONDA, S., G. HILEMAN, and S. UPADRASHTA. "Controlled release pellets by extrusion-spheronization." International Journal of Pharmaceutics 111, no. 1 (October 6, 1994): 89–97. http://dx.doi.org/10.1016/0378-5173(94)90405-7.

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6

Iyer, R. M., L. L. Augsburger, D. G. Pope, and R. D. Shah. "Extrusion/Spheronization—Effect of Moisture Content and Spheronization Time on Pellet Characteristics." Pharmaceutical Development and Technology 1, no. 4 (January 1996): 325–31. http://dx.doi.org/10.3109/10837459609031427.

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7

M. P., Gowrav, Umme Hani, Hosakote G. Shivakumar, Riyaz Ali M. Osmani, and Atul Srivastava. "Polyacrylamide grafted guar gum based glimepiride loaded pH sensitive pellets for colon specific drug delivery: fabrication and characterization." RSC Advances 5, no. 97 (2015): 80005–13. http://dx.doi.org/10.1039/c5ra17257h.

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8

Steckel, H., and F. Mindermann-Nogly. "Production of chitosan pellets by extrusion/spheronization." European Journal of Pharmaceutics and Biopharmaceutics 57, no. 1 (January 2004): 107–14. http://dx.doi.org/10.1016/s0939-6411(03)00156-5.

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9

Jadhav, Namdeo, Preeti Irny, Ashwini Mokashi, Pravin Souche, and Anant Paradkar. "Pelletization by Extrusion Spheronization Technique: An Excipient Review." Drug Delivery Letterse 2, no. 2 (July 1, 2012): 132–45. http://dx.doi.org/10.2174/2210303111202020132.

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10

Jadhav, Namdeo, Preeti Irny, Ashwini Mokashi, Pravin Souche, and Anant Paradkar. "Pelletization by Extrusion Spheronization Technique: An Excipient Review." Drug Delivery Letters 2, no. 2 (July 1, 2012): 132–45. http://dx.doi.org/10.2174/2210304x11202020132.

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11

Barkate, Akshay R., Sunil B. Bothara, Paresh R. Mahaparale, Priyanka S. Lohar, and Somnath B. Tambade. "Methods of Pelletization Using Extrusion – Spheronization: A Review." International Journal of Pharmacy and Pharmaceutical Research 18, no. 1 (April 30, 2020): 385–99. http://dx.doi.org/10.25166/ijppr.2020.v18i01.029.

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12

Mahrous, G. M., M. A. Ibarhim, M. El-Badry, and F. K. Al-Anazi. "Indomethacin sustained release pellets prepared by extrusion-spheronization." Journal of Drug Delivery Science and Technology 20, no. 2 (2010): 119–25. http://dx.doi.org/10.1016/s1773-2247(10)50016-9.

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13

Montoussé, C., M. Pruvost, F. Rodriguez, and C. Brossard. "Extrusion–Spheronization Manufacture of Gelucire® Matrix Beads." Drug Development and Industrial Pharmacy 25, no. 1 (January 1999): 75–80. http://dx.doi.org/10.1081/ddc-100102144.

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14

M. Mahrous, Gamal. "KETOROLAC ENTERIC MATRIX PELLETS PRODUCED BY EXTRUSION / SPHERONIZATION." Bulletin of Pharmaceutical Sciences. Assiut 33, no. 1 (June 30, 2010): 51–58. http://dx.doi.org/10.21608/bfsa.2010.147023.

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15

Manda, Arthur, Roderick Walker, and Sandile Khamanga. "An Artificial Neural Network Approach to Predict the Effects of Formulation and Process Variables on Prednisone Release from a Multipartite System." Pharmaceutics 11, no. 3 (March 7, 2019): 109. http://dx.doi.org/10.3390/pharmaceutics11030109.

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The impact of formulation and process variables on the in-vitro release of prednisone from a multiple-unit pellet system was investigated. Box-Behnken Response Surface Methodology (RSM) was used to generate multivariate experiments. The extrusion-spheronization method was used to produce pellets and dissolution studies were performed using United States Pharmacopoeia (USP) Apparatus 2 as described in USP XXIV. Analysis of dissolution test samples was performed using a reversed-phase high-performance liquid chromatography (RP-HPLC) method. Four formulation and process variables viz., microcrystalline cellulose concentration, sodium starch glycolate concentration, spheronization time and extrusion speed were investigated and drug release, aspect ratio and yield were monitored for the trained artificial neural networks (ANN). To achieve accurate prediction, data generated from experimentation were used to train a multi-layer perceptron (MLP) using back propagation (BP) and the Broyden-Fletcher-Goldfarb-Shanno (BFGS) 57 training algorithm until a satisfactory value of root mean square error (RMSE) was observed. The study revealed that the in-vitro release profile of prednisone was significantly impacted by microcrystalline cellulose concentration and sodium starch glycolate concentration. Increasing microcrystalline cellulose concentration retarded dissolution rate whereas increasing sodium starch glycolate concentration improved dissolution rate. Spheronization time and extrusion speed had minimal impact on prednisone release but had a significant impact on extrudate and pellet quality. This work demonstrated that RSM can be successfully used concurrently with ANN for dosage form manufacture to permit the exploration of experimental regions that are omitted when using RSM alone.

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16

Rojas, John, and David Correa. "ASSESSMENT OF THE PRODUCTION VARIABLES ON THE PELLETIZATION PROPERTIES OF MICROCRYSTALLINE CELLULOSE II (MCCII)." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (October 2, 2017): 73. http://dx.doi.org/10.22159/ijpps.2017v9i10.20580.

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Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid using the extrusion/spheronization technology.Methods: The effect of the spheronization rate and spheronization time was assessed by a response surface design. The shape descriptors and physical properties of pellets were taken as response variables. Approximately, 30 g of MCCII were hydrated, passed through a # 20 mesh sieve and spheronizated at frequencies of 6, 9 and 12 Hz and residence times of 15, 240 and 480 s in 9 experimental runs. In a separate experimental set, moisture levels of 25, 50, 75, 100 and 125% were employed at the optimal operating conditions of 6 Hz and 480 s. A microscopy analysis was used to evaluate the shape descriptors. Pellets properties such as compressibility, friability, porosity, strength, flow rate and mass were also evaluated.Results: Pellets having a small size and a high value of shape descriptors related to morphology were obtained employing a spheronization rate and spheronization time of 6Hz and 480s and 100% wetting level. The spheronization time increased pellet densification but decreased the total porosity. Pellet mass was also favoured by using high spheronization rates. A high moisture level (>100%) rendered pellets having a large size, mass, low porosity and good yield. Conversely, pellet size decreased as sample load increased, whereas porosity and compressibility increased as sample load augmented.Conclusion: MCCII offers the potential for use as an alternative pelletization agent rendering pellets having a good flowability, high mechanical strength and low friability at the optimal operational conditions.

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17

KOESTER. "New Insights into the Pelletization Mechanism by Extrusion/Spheronization." Scientia Pharmaceutica 78, no. 3 (2010): 640. http://dx.doi.org/10.3797/scipharm.cespt.8.pms13.

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18

Sandler, Niklas, Jukka Rantanen, Jyrki Heinämäki, Meike Römer, Martti Marola, and Jouko Yliruusi. "Pellet manufacturing by extrusion-spheronization using process analytical technology." AAPS PharmSciTech 6, no. 2 (June 2005): E174—E183. http://dx.doi.org/10.1208/pt060226.

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19

Koester, Martin, and Markus Thommes. "New Insights into the Pelletization Mechanism by Extrusion/Spheronization." AAPS PharmSciTech 11, no. 4 (November 2, 2010): 1549–51. http://dx.doi.org/10.1208/s12249-010-9532-7.

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20

Bajaj, Poonam R., Shrikant A. Survase, Mahesh V. Bule, and Rekha S. Singhal. "Studies on Viability ofLactobacillus fermentumby Microencapsulation Using Extrusion Spheronization." Food Biotechnology 24, no. 2 (May 28, 2010): 150–64. http://dx.doi.org/10.1080/08905436.2010.482010.

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21

Goskonda, Sanjay R., and Sathyanarayana M. Upadrashta. "Avicel RC-591/Chitosan Beads by Extrusion-Spheronization Technology." Drug Development and Industrial Pharmacy 19, no. 8 (January 1993): 915–27. http://dx.doi.org/10.3109/03639049309062991.

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22

Muley, Sagar, Tanaji Nandgude, and Sushilkumar Poddar. "Extrusion–spheronization a promising pelletization technique: In-depth review." Asian Journal of Pharmaceutical Sciences 11, no. 6 (December 2016): 684–99. http://dx.doi.org/10.1016/j.ajps.2016.08.001.

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23

Law, M. F. L., and P. B. Deasy. "Effect of common classes of excipients on extrusion-spheronization." Journal of Microencapsulation 14, no. 5 (January 1997): 647–57. http://dx.doi.org/10.3109/02652049709006817.

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24

Tomer, G., F. Podczeck, and J. M. Newton. "The influence of model drugs on the preparation of pellets by extrusion/spheronization: II spheronization parameters." International Journal of Pharmaceutics 231, no. 1 (January 2002): 107–19. http://dx.doi.org/10.1016/s0378-5173(01)00876-6.

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25

Rhee, Yun-Seok, Jae-Hwi Lee, Beom-Jin Lee, and Eun-Seok Park. "Controlled-Release Pelletized Dosage Forms Using the Extrusion-Spheronization Process." Journal of Pharmaceutical Investigation 40, spc (May 15, 2010): 103–12. http://dx.doi.org/10.4333/kps.2010.40.s.103.

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26

Beringhs, André O., Fagner M. Souza, Angela M. de Campos, Humberto G. Ferraz, and Diva Sonaglio. "Technological development of Cecropia glaziovi extract pellets by extrusion-spheronization." Revista Brasileira de Farmacognosia 23, no. 1 (January 2013): 160–68. http://dx.doi.org/10.1590/s0102-695x2012005000123.

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27

Otero-Espinar, F. J., A. Luzardo-Alvarez, and J. Blanco-Méndez. "Non-MCC materials as extrusion-spheronization aids in pellets production." Journal of Drug Delivery Science and Technology 20, no. 4 (2010): 303–18. http://dx.doi.org/10.1016/s1773-2247(10)50047-9.

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28

Gomez-Amoza, J. L., and R. Martinez-Pacheco. "Influence of microstructure on drug release from extrusion-spheronization pellets." Journal of Drug Delivery Science and Technology 20, no. 4 (2010): 319–25. http://dx.doi.org/10.1016/s1773-2247(10)50048-0.

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29

Rodriguez-Gómez, A., S. Anguiano-Igea, F. J. Otero-Espinar, and J. Blanco-Méndez. "Effect of bioadhesive polymers on pellets obtained by extrusion/spheronization." European Journal of Pharmaceutical Sciences 4 (September 1996): S176. http://dx.doi.org/10.1016/s0928-0987(97)86533-5.

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30

Harrison, P. J., J. M. Newton, and R. C. Rowe. "The characterization of wet powder masses suitable for extrusion/spheronization." Journal of Pharmacy and Pharmacology 37, no. 10 (October 1985): 686–91. http://dx.doi.org/10.1111/j.2042-7158.1985.tb04943.x.

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31

Xia, Yu, Chun-Yang Shi, Jian-Guo Fang, and Wen-Qing Wang. "Approaches to developing fast release pellets via wet extrusion-spheronization." Pharmaceutical Development and Technology 23, no. 5 (December 9, 2016): 432–41. http://dx.doi.org/10.1080/10837450.2016.1265556.

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32

Thommes, Markus, and Peter Kleinebudde. "The Behavior of Different Carrageenans in Pelletization by Extrusion/Spheronization." Pharmaceutical Development and Technology 13, no. 1 (January 2008): 27–35. http://dx.doi.org/10.1080/10837450701702537.

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33

Gómez-Carracedo, A., C. Alvarez-Lorenzo, J. L. Gómez-Amoza, R. Martínez-Pacheco, C. Souto, and A. Concheiro. "Extrusion-Spheronization of Blends of Carbopol 934 and Microcrystalline Cellulose." Drug Development and Industrial Pharmacy 27, no. 5 (January 2001): 381–91. http://dx.doi.org/10.1081/ddc-100104313.

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34

Goyanes, Alvaro, Consuelo Souto, and Ramón Martínez-Pacheco. "Co-processed MCC-Eudragit® E excipients for extrusion–spheronization." European Journal of Pharmaceutics and Biopharmaceutics 79, no. 3 (November 2011): 658–63. http://dx.doi.org/10.1016/j.ejpb.2011.07.013.

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35

Almeida Prieto, S., J. Blanco Méndez, and F. J. Otero Espinar. "Starch–dextrin mixtures as base excipients for extrusion–spheronization pellets." European Journal of Pharmaceutics and Biopharmaceutics 59, no. 3 (April 2005): 511–21. http://dx.doi.org/10.1016/j.ejpb.2004.09.010.

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36

Soh, J. L. P., C. V. Liew, and P. W. S. Heng. "Torque rheological parameters to predict pellet quality in extrusion–spheronization." International Journal of Pharmaceutics 315, no. 1-2 (June 2006): 99–109. http://dx.doi.org/10.1016/j.ijpharm.2006.02.023.

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37

Kanbe, Hideyoshi, Tetsuo Hayashi, Yoichi Onuki, and Takashi Sonobe. "Manufacture of fine spherical granules by an extrusion/spheronization method." International Journal of Pharmaceutics 337, no. 1-2 (June 2007): 56–62. http://dx.doi.org/10.1016/j.ijpharm.2006.12.020.

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38

Alshora, Doaa Hasan, Mohamed Abbas Ibrahim, Essam Ezzeldin, and Muzaffar Iqbal. "Optimized flurbiprofen sustained-release matrix pellets prepared by extrusion/spheronization." Journal of Drug Delivery Science and Technology 59 (October 2020): 101902. http://dx.doi.org/10.1016/j.jddst.2020.101902.

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39

Dudhamal, S. S., P. S. Kawtikwar, and S. N. Nagoba. "FORMULATION AND EVALUATION OF DISPERSIBLE PELLETS OF LAGENARIA SICERARIA." Asian Journal of Pharmaceutical Research and Development 6, no. 4 (August 29, 2018): 81–85. http://dx.doi.org/10.22270/ajprd.v6i4.400.

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Lagenaria siceraria (Bottle gourd) is a common name in every household. Its medicinal values were identified many years ago, and still people use this plant for many disorders. Extrusion spheronization technique was employed for preparation of the pellets, to study the effect of crosscarmellose sodium, on it. The pellets were prepared by use of combination of Avicel PH 101 and lactose that indicated good flow properties. The superdisintegrant used was crosscarmellose sodium between concentration 2 to 8%, to study the effect of it on the pellets. The superdisintegrant showed low disintegration time at low concentration, while as the concentration of it increased, it extended the disintegration time. Thus, optimum concentration needs to be designed for successful formulation. Batch D3 of 6% crosscarmellose sodium concentration showed the requisite characteristic in terms of all the evaluation parameters, with DT up to 50 to 55 seconds. Thus, use of this superdisintegrant alone, but in low concentration, can be helpful, or else combination of this with other superdisintegrants can be approached, or else new superdisintegrants can be tried. Thus, the study indicated the effect of superdisintegrant for formulation of dispersible pellets. Keywords: Extrusion-Spheronization, Crosscarmellose sodium, Lagenaria siceraria, Pellets

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40

Kanwar, Navjot, Rakesh Kumar, and V. R. Sinha. "Preparation and Evaluation of Multi-Particulate System (Pellets) of Prasugrel Hydrochloride." Open Pharmaceutical Sciences Journal 2, no. 1 (December 18, 2015): 74–80. http://dx.doi.org/10.2174/1874844901502010074.

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Multiparticulate systems (pellets) of prasugrel hydrochloride were prepared by extrusion spheronization method using MCC (micro crystalline cellulose). Optimum spheronization time and method of drying were selected as the process parameters for the preparation of final batches. Various pellet properties were evaluated like size & shape analysis, flow properties, bulk & tapped density, friability, moisture content, drug content, in vitro release rate and in vivo pharmacodynamic studies. All pellet batches showed a narrow particle size distribution, good sphericity and excellent flow properties. Drug content and moisture content of different pellet batches were found in specified limits. The release kinetics of drug loaded MCC pellets followed Peppas model with Fickian diffusion of prasugrel from the pellets. In vivo pharmacodynamic studies exhibited improved bleeding time in pellet group when compared with the marketed tablet formulation.

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41

Tuleu, C., and J. C. Chaumeilm. "Small-Scale Characterization of Wet Powder Masses Suitable for Extrusion-Spheronization." Drug Development and Industrial Pharmacy 24, no. 5 (January 1998): 423–29. http://dx.doi.org/10.3109/03639049809085639.

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42

Varshosaz, J., R. A. Kennedy, and E. M. Gipps. "Use of enteric polymers for production of microspheres by extrusion-spheronization." Pharmaceutica Acta Helvetiae 72, no. 3 (June 1997): 145–52. http://dx.doi.org/10.1016/s0031-6865(97)00005-8.

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43

Law, Michelle F. L., and Patrick B. Deasy. "Use of hydrophilic polymers with microcrystalline cellulose to improve extrusion–spheronization." European Journal of Pharmaceutics and Biopharmaceutics 45, no. 1 (January 1998): 57–65. http://dx.doi.org/10.1016/s0939-6411(97)00123-9.

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44

Sousa, J. J., A. Sousa, F. Podczeck, and J. M. Newton. "Factors influencing the physical characteristics of pellets obtained by extrusion-spheronization." International Journal of Pharmaceutics 232, no. 1-2 (January 2002): 91–106. http://dx.doi.org/10.1016/s0378-5173(01)00908-5.

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45

Tho, Ingunn, Peter Kleinebudde, and Sverre Arne Sande. "Extrusion/spheronization of pectin-based formulations. I. Screening of important factors." AAPS PharmSciTech 2, no. 4 (December 2001): 54–62. http://dx.doi.org/10.1208/pt020426.

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46

Edimo, A., P. Leterme, J. Denis, H. Traisnell, and A. T. Gayot. "Capacity of Lipophilic Auxiliary Substances to Give Spheres by Extrusion-Spheronization." Drug Development and Industrial Pharmacy 19, no. 7 (January 1993): 827–42. http://dx.doi.org/10.3109/03639049309062985.

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47

Ku, Cathy C., Yatindra M. Joshi, James S. Bergum, and Nemi B. Jain. "Bead Manufacture by Extrusion/spheronization – a Statistical Design for Process Optimization." Drug Development and Industrial Pharmacy 19, no. 13 (January 1993): 1505–19. http://dx.doi.org/10.3109/03639049309069323.

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48

SCHMIDT, Christian, and Peter KLEINEBUDDE. "Influence of the Granulation Step on Pellets Prepared by Extrusion/Spheronization." CHEMICAL & PHARMACEUTICAL BULLETIN 47, no. 3 (1999): 405–12. http://dx.doi.org/10.1248/cpb.47.405.

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49

Evers, Maria, Dominik Weis, Sergiy Antonyuk, and Markus Thommes. "Scale-up of the rounding process in pelletization by extrusion-spheronization." Pharmaceutical Development and Technology 24, no. 8 (June 24, 2019): 1014–20. http://dx.doi.org/10.1080/10837450.2019.1621900.

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50

Gao, Ya, Yanlong Hong, Jiechen Xian, Xiao Lin, Lan Shen, Xue Zhang, Ning Zhang, and Yi Feng. "A protocol for the classification of wet mass in extrusion–spheronization." European Journal of Pharmaceutics and Biopharmaceutics 85, no. 3 (November 2013): 996–1005. http://dx.doi.org/10.1016/j.ejpb.2013.03.016.

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