Relevant bibliographies by topics / F-DPA-714

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Academic literature on the topic 'F-DPA-714'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "F-DPA-714"

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Vicidomini, Caterina, Mariarosaria Panico, Adelaide Greco, et al. "In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET." Nucl Med Biol. 42, no. 3 (2014): 309–16. https://doi.org/10.1016/j.nucmedbio.2014.11.009.

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INTRODUCTION: The translocator protein 18kDa (TSPO), a biochemical marker of neuroinflammation, is highly expressed in the brain activated microglia and it is also expressed by peripheral inflammatory cells and normal peripheral tissues. Thus, development of radioligands for the TSPO may contribute to further understanding the in vivo TSPO function in central and peripheral inflammatory processes and other pathologies. Here, we report the biodistribution, the specific binding and the radiometabolites of [(18)F]DPA-714, a promising fluorinated PET radiotracer, in normal mice using a microP
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Keller, Thomas, Anna Krzyczmonik, Sarita Forsback, et al. "Radiosynthesis and Preclinical Evaluation of [18F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats." Molecular Imaging & Biology 19, no. 5 (2017): 736–45. https://doi.org/10.1007/s11307-016-1040-z.

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PURPOSE: Many neurological conditions result in the overexpression of the translocator protein 18&nbsp;kDa (TSPO), today recognized as a biomarker for microglial activation and neuroinflammation imaging. The pyrazolo[1,5-a]pyrimidine acetamides are a particularly attractive class of TSPO-specific ligands, prompting the development of several positron emission tomography (PET) radiotracers. This includes F-DPA, a recently reported fluorinated ligand (K <sub>i</sub>&thinsp;=&amp;thinsp;1.7&nbsp;nM), wherein the fluorine atom is directly linked to the phenyl moiety without the presence of an alky
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Ory, Dieter, Andrey Postnov, Michel Koole, et al. "Quantification of TSPO overexpression in a rat model of local neuroinflammation induced by intracerebral injection of LPS by the use of [(18)F]DPA-714 PET." Eur J Nucl Med Mol Imaging 43, no. 1 (2015): 163–72. https://doi.org/10.1007/s00259-015-3172-9.

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PURPOSE: [(18)F]DPA-714 is a radiotracer with high affinity for TSPO. We have characterized the kinetics of [(18)F]DPA-714 in rat brain and evaluated its ability to quantify TSPO expression with PET using a neuroinflammation model induced by unilateral intracerebral injection of lipopolysaccharide (LPS). METHODS: Dynamic small-animal PET scans with [(18)F]DPA-714 were performed in Wistar rats on a FOCUS-220 system for up to 3&nbsp;h. Both plasma and perfused brain homogenates were analysed using HPLC to quantify radiometabolites. Full kinetic modelling of [(18)F]DPA-714 brain uptake was perfor
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Awde, Ali R., Raphael Boisgard, Benoit Thézé, et al. "The Translocator Protein Radioligand 18F-DPA-714 Monitors Antitumor Effect of Erufosine in a Rat 9L Intracranial Glioma Model." Journal of Nuclear Medicine 54, no. 12 (2013): 2125–31. https://doi.org/10.2967/jnumed.112.118794.

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On the one hand, the translocator protein (TSPO) radioligand N,N-diethyl-2-(2-(4-(2-(18)F-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ((18)F-DPA-714) has been suggested to serve as an alternative radiotracer to image human glioma, and on the other hand the alkylphosphocholine erufosine (ErPC3) has been reported to induce apoptosis in otherwise highly apoptosis-resistant glioma cell lines. The induction of apoptosis by ErPC3 requires TSPO, a mitochondrial membrane protein highly expressed in malignant gliomas. In this preclinical study, we monitored the effect of Er
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Takkinen, Jatta S., Francisco R. López-Picón, Majidi Rana Al, et al. "Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging." Journal of Cerebral Blood Flow and Metabolism 37, no. 8 (2016): 2870–82. https://doi.org/10.1177/0271678X16677990.

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Preclinical animal model studies of brain energy metabolism and neuroinflammation in Alzheimer&#39;s disease have produced conflicting results, hampering both the elucidation of the underlying disease mechanism and the development of effective Alzheimer&#39;s disease therapies. Here, we aimed to quantify the relationship between brain energy metabolism and neuroinflammation in the APP/PS1-21 transgenic mouse model of Alzheimer&#39;s disease using longitudinal in&nbsp;vivo <sup>18</sup>F-FDG and <sup>18</sup>F-DPA-714) PET imaging and ex vivo brain autoradiography. APP/PS1-21 (TG, n&thinsp;=&am
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Golla, Sandeep SV, Ronald Boellaard, Vesa Oikonen, et al. "Parametric binding images of the TSPO ligand [18F]DPA-714." Journal of Nuclear Medecine 57, no. 10 (2016): 1543–47. https://doi.org/10.2967/jnumed.116.173013.

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Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-&alpha;]pyrimidine-3-yl)acetamide (<sup>18</sup>F-DPA-714) is a radioligand for the 18-kDa translocator protein. The purpose of the present study was to identify the best method for generating quantitative parametric images of <sup>18</sup>F-DPA-714 binding. METHODS: Ninety minutes dynamic <sup>18</sup>F-DPA-714 positron emission tomography scans with full arterial sampling from 6 healthy subjects and 9 Alzheimer&#39;s disease (AD) patients were used. Plasma input based Logan graphical and spectral (SA) a
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Sridharan, Sujata, Francois-Xavier Lepelletier, William Trigg, et al. "Comparative Evaluation of Three TSPO PET Radiotracers in a LPS-Induced Model of Mild Neuroinflammation in Rats." Molecular Imaging & Biology 19 (August 1, 2016): 77–89. https://doi.org/10.1007/s11307-016-0984-3.

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PURPOSE: Over the past 20&nbsp;years, neuroinflammation (NI) has increasingly been recognised as having an important role in&nbsp; many neurodegenerative diseases, including Alzheimer&#39;s disease. As such, being able to image NI non-invasively in patients is critical to monitor pathological processes and potential therapies targeting neuroinflammation. The translocator protein (TSPO) has proven a reliable NI biomarker for positron emission tomography (PET) imaging. However, if TSPO imaging in acute conditions such as stroke provides strong and reliable signals, TSPO imaging in neurodegenerat
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Golla, Sandeep SV, Ronald Boellaard, Vesa Oikonen, et al. "Quantification of [18F]DPA-714 Binding in the Human Brain: Initial Studies in Healthy Controls and Alzheimer'S Disease Patients." Journal of Cerebral Blood Flow & Metabolism 35, no. 5 (2015): 766–72. http://dx.doi.org/10.1038/jcbfm.2014.261.

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Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide ([18F] DPA-714) binds to the 18-kDa translocator protein (TSPO) with high affinity. The aim of this initial methodological study was to develop a plasma input tracer kinetic model for quantification of [18F]DPA-714 binding in healthy subjects and Alzheimer's disease (AD) patients, and to provide a preliminary assessment whether there is a disease-related signal. Ten AD patients and six healthy subjects underwent a dynamic positron emission tomography (PET) study along with arte
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Golla, Sandeep SV, Ronald Boellaard, Vesa Oikonen, et al. "Quantification of [18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients." Journal of Cerebral Blood Flow and Metabolism 35, no. 5 (2015): 766–72. https://doi.org/10.1038/jcbfm.2014.261.

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Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-&alpha;]pyrimidine-3-yl)acetamide ([18F]DPA-714) binds to the 18-kDa translocator protein (TSPO) with high affinity. The aim of this initial methodological study was to develop a plasma input tracer kinetic model for quantification of [18F]DPA-714 binding in healthy subjects and Alzheimer&#39;s disease (AD) patients, and to provide a preliminary assessment whether there is a disease-related signal. Ten AD patients and six healthy subjects underwent a dynamic positron emission tomography (PET) study along
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10

Gargiulo, S., S. Anzilotti, ARD Coda, et al. "Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with 18F-DPA-714 and micro-PET/CT." European Journal of Nuclear Medecine and Molecular Imaging 43, no. 7 (2016): 1348–59. https://doi.org/10.1007/s00259-016-3311-y.

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PURPOSE: To evaluate the feasibility and sensitivity of <sup>18</sup>F-DPA-714 for the study of microglial activation in the brain and spinal cord of transgenic SOD1<sup>G93A</sup> mice using high-resolution PET/CT and to evaluate the Iba1 and TSPO expression with immunohistochemistry. METHODS: Nine symptomatic SOD1<sup>G93A</sup> mice (aged 117&thinsp;&plusmn;&thinsp;12.7&nbsp;days, clinical score range 1&nbsp;-&nbsp;4) and five WT SOD1 control mice (aged 108&thinsp;&plusmn;&thinsp;28.5&nbsp;days) underwent <sup>18</sup>F-DPA-714 PET/CT. SUV ratios were calculated by normalizing the cerebella
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Dissertations / Theses on the topic "F-DPA-714"

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Bernards, Nicholas. "PET molecular imaging of peripheral and central inflammatory processes targeting the TSPO 18 kDa." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112211/document.

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L’objectif de la thèse: À ce jour, il est admis que la TSPO joue un rôle important dans le processus inflammatoire, et qu’il est possible de suivre sa présence à l’aide d’une variété de radiotraceurs adaptés. Les impacts de l’inflammation touchent un grand nombre de personnes à travers le monde pour diverses raisons ; c’est pourquoi, quoique le [ ¹ ⁸F]DPA-714 est très prometteur, il est nécessaire d’aller plus loin pour explorer ses capacités et ses applications possibles. L’inflammation a une forte incidence sur différentes maladies, par conséquent, à impact social élevé (comme la maladie inf
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Hamelin, Lorraine. "Analyse de la morphologie des sillons corticaux et de l'activation microgliale dans la maladie d'Alzheimer : étude couplée en IRM, TEP-PiB et TEP-DPA Sulcal morphology as a new imaging marker for the diagnosis of early onset Alzheimer’s disease Early and protective microgial activation in Alzheimer's diease: a prospective study using 18F-DPA-714 PET imaging Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer’s disease." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2327&f=13526.

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La maladie d’Alzheimer (MA) est la première cause de démence dégénérative. Elle est ‏définie par l’accumulation anormale des protéines Tau et myloïdes, constituant des plaques‏ amyloïdes. Alors que l’atteinte neuro-pathologique de la MA est stéréotypée chez les malades, son ‏expression clinique et son pronostic sont hétérogènes. Les facteurs modulant l’expression de la ‏maladie sont actuellement peu connus.‏ Dans ce travail, nous avons analysé deux facteurs modulateurs de l’expression de la ‏maladie : l’âge et l’activation microgliale que nous avons étudié au sein d’une population de sujets‏ a
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Conference papers on the topic "F-DPA-714"

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Backhaus, P., W. Roll, C. Beuker, et al. "Imaging TSPO expression with F-18-DPA-714 PET/MRI in Patients with Suspected PACNS." In NuklearMedizin 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1683516.

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