Journal articles: 'F substance'

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Kornely, Dominique, and Kameko Halfmann. "Psychosocial Stress and Attitudes Toward Substance Use Among College Students: An Exploratory Study." Psi Chi Journal of Psychological Research 25, no. 4 (2020): 338–48. http://dx.doi.org/10.24839/2325-7342.jn25.4.338.

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Substance use occurs on college campuses nationwide and is among the top threats to college-student health. The present study aimed to explore the impact of stress on substance use attitudes. The independent variable was acute psychosocial stress, induced using the Trier Social Stress Test. We measured chronic stress using the Adverse Childhood Experiences questionnaire. The Alcohol Purchase Task (i.e., alcohol demand, alcohol breakpoint, alcohol expenditure) and the Cognitive Appraisal of Risky Events-Revised questionnaire (i.e., expected involvement with substances and expected benefits and consequences of using substances) were the dependent variables. We predicted that participants who completed the acute stress task would report greater attitudes toward substance use behaviors and this would be more pronounced for those with higher levels of chronic stress. Acute stress did not affect willingness to pay for alcohol, F(3, 85) = 0.55, p = .65, ηp2 = 0.02, or expected positive or negative consequences from engaging in substance use, F(3, 85) = 0.44, p = .73, ηp2 = 0.02. There was a small positive association between chronic stress, as measured by adverse childhood experiences, and expected use, ρ(89) = .22, p = .04. In exploratory analyses, we found expected positive benefits of substance use to be significantly associated with expected future involvement, whereas expected negative consequences of substance use was associated with expected future involvement. Our results imply that acute and chronic stress were not significant in predicting substance use behaviors. Rather, those who expect benefits are more likely to use substances.

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Toledo-Fernández, Aldebarán, Luis Villalobos-Gallegos, and Rodrigo Marín-Navarrete. "Is the Mini-Mental State Examination (MMSE) useful for eligibility screening of research participants with substance use disorder?" Revista Internacional de Investigación en Adicciones 2, no. 1 (January 1, 2016): 39–44. http://dx.doi.org/10.28931/riiad.2016.1.06.

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Introduction: the MMSE is used for eligibility screening of potential research participants diagnosed with substance use disorder (SUD), as abilities needed to provide a valid informed consent or accurate information could be impaired in these clinical populations. Knowledge about the capacity of the MMSE to detect impairment in these abilities or at least to assess impact of SUD on its total score, however, is rather diffuse. This has important ethical and methodological implications. Objective: to analyze effects of SUD only, main substances of abuse, age of onset of substance use, recent substance use, and psychiatric comorbidity upon MMSE outcome. The overall purpose of the study was to assess the utility of the MMSE for eligibility screening of potential research participants with SUD. Method: individuals were recruited from residential facilities for substance use treatment. A demographic questionnaire, MMSE and Mini International Neuropsychiatric Interview were used. Results: A total of 601 participants were gathered for main analysis. Controlling for education, no differences in MMSE score were detected within main substances of abuse (F=1.25[4,529], p=.28), nor between SUD only versus SUD with psychiatric comorbidity (F=.58[1,597], p=.44). Effects of age of onset and recent use of specific substances upon MMSE score were also absent. Discussion and conclusions: If there is some cognitive impairment in this clinical population, it may not be pertinently assessed by the MMSE, thus casting doubt on its pertinence for eligibility screening.

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Agzamova, Manzura Adkhamovna, Ravshanjon Muratjanovich Khalilov, and Abdulaziz Adilkhanovich Janibekov. "СHROMATOGRAPHIC ANALYSIS OF СYCLOSIVERSIOSIDE F." chemistry of plant raw material, no. 2 (June 10, 2021): 267–74. http://dx.doi.org/10.14258/jcprm.2021028314.

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The plants Astragalus pterocephalus growing in Uzbekistan are a source of triterpene glycosides. The main triterpene glycoside, in terms of content, is a cycloartan glycoside – cyclosiversioside F. To obtain an individual biologically active compound cyclosiversioside F with 95% purity, a proposed method involves extraction with methanol, concentration and dilution with an equal volume of water, then followed by a sequential extraction from the aqueous extract with chloroform, ethyl acetate and butanol. Then a chromatographic separation of the purified amount of extractives on a column with silica gel, isolation of the substance and precipitation from a solvent system must be performed, followed by recrystallization and drying. The optimal conditions for the isolation and separation of the amount of extractive substances have been developed in order to obtain an individual glycoside. Cyclosiversioside F was authenticated by TLC in comparison with an authentic sample. Quantitative analysis of the glycoside was carried out by HPLC. The purity of cyclosiversioside F was confirmed by taking 1H and 13C NMR spectra.

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Stoolmiller, Mike, and Elaine A. Blechman. "Substance Use is a Robust Predictor of Adolescent Recidivism." Criminal Justice and Behavior 32, no. 3 (June 2005): 302–28. http://dx.doi.org/10.1177/0093854804274372.

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How well does substance use predict adolescent recidivism? When the Cox proportional hazards model was applied to officially recorded first rearrest of 505 juvenile offenders, a best-fitting complex multivariate model indicated that: (a) parent reports that youths “often” use substances more than doubles first rearrest risk, (b) averaged youth and parent substance use reports predict recidivism better than a single source, (c) parent or youth denial of youth substance use predicts recidivism, (d) age at first arrest does not predict recidivism, (e) non-White/non-Asians have a 79% higher recidivism risk than peers, (f) parent-reported delinquency predicts recidivism with declining accuracy, and (g) substance use robustly predicts recidivism despite prior reported delinquency, gender, ethnicity, age, follow-up time, or data source. Findings are related to host-provocation theory.

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Leghari, Naeem Ullah, Zakia Bano, Zoofishan Ahmad, and Bushra Akram. "SUBSTANCE USE DISORDER." Professional Medical Journal 25, no. 02 (February 10, 2018): 325–31. http://dx.doi.org/10.29309/tpmj/2018.25.02.466.

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Introduction: In the present study social support will be defined in order tofind its moderating role in depression among people with substance use disorder. Objectives:The Objective of the study was to explore that stigma is a significant predictor of depressionin people with substance used disorder. Further, the study aim was to explore the significantrole of perceived social support in depression among the people with substance use disorder.Study Design: Sample was collected through purposive sampling technique. Setting, Period:Sample was gathered from different treatment and rehabilitation centers situated across Sialkot andMultan from August 2015 to June 2016. Material & Methods: Sample included 200 maleswith substance used disorder between age range of 20 to 50 (Mean age = 31.34, S.D = 7.988)were assessed on perceived stigma of substance abuse scale (Loma, O’ Hair, Knollenberg, Hayes,& Fletcher, 2010) and Saddiqui Shah Depression Scale (Shah, 1992). Regression analysis wasapplied to analyze the hypotheses. Results: The results reflected significant relationship ofperceived stigma and depression (r= .464; F (54.275), p<.001; R²=.215]. Resultshows perceived social support as a moderator between stigma and depression among peoplewith substance use disorder (r =.565; F (46.138), p<.001; R2=319]. Conclusion: Stigmatizingattitude of significant others in people with substance use disorder is increasing the negativefeelings among people with substance use disorder. Perception of this blaming attitude byother causes a deep effect on them and they suffer depression. Further, the Perception of socialsupport from others plays a momentous role in the lives of people it is helpful to cope all theproblems.

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Benkovits, J., P. Polgár, Á. Fábián, P. Czobor, I. Bitter, and J. Réthelyi. "The effect of DTNBP1 and comt risk variants and comorbid drug-abuse in patients with schizophrenia: A Gene-Environment Interaction?" European Psychiatry 26, S2 (March 2011): 1345. http://dx.doi.org/10.1016/s0924-9338(11)73050-4.

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IntroductionEarlier studies have shown that candidate gene risk polymorphisms and psychoactive substance abuse influence the frequency and severity of psychosis.ObjectivesIn this study we examined whether the most studied schizophrenia risk polymorphisms and psychoactive substance abuse interact in their influence on symptom severity and neurocognition.MethodsWe analyzed the clinical data of 280 schizophrenia patients, including genotyping data of the candidate genes NRG1, DTNBP1, RGS4, G72/G30 and PIP5K2A. Patients were assessed clinically by the Positive and Negative Symptom Scale (PANSS) and information about substance abuse was based on self-report and reviewing patient charts. We tested for possible interactional effects using the General Linear Model (GLM) analysis.Results15,8% of patients reported episodic or regular substance abuse, the vast majority (92%) used cannabis or the combination of cannabis and another drug. Substance abuse was associated with higher scores of the PANSS hostility/excitement factor, independent of sex, age, or genetic results (F = 4,02;p = 0,04). We found significant interactional effects of the DTNBP1 gene risk polymorphisms and substance abuse on different PANSS factors: rs2619528 and positive substance abuse interaction were associated with higher scores on the PANSS negative factor (F = 4,6;p = 0,03), and the PANSS depression factor (F = 4,75;p = 0,03). Moreover the rs3213207 - substance abuse interaction was associated with higher scores on the PANSS cognitive factor (F = 7,55;p = 0,006). Carriers of the Val allele of the COMT Val158Met polymorphism demonstrated significantly higher scores on the PANSS depression factor (F = 5,53;p = 0,02).ConclusionsOur results underscore the importance of gene-environment interactions in the phenotypic heterogeneity of schizophrenia.

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Lewis, Todd F., and A. Keith Mobley. "Substance Abuse and Dependency Risk: The Role of Peer Perceptions, Marijuana Involvement, and Attitudes toward Substance Use among College Students." Journal of Drug Education 40, no. 3 (September 2010): 299–314. http://dx.doi.org/10.2190/de.40.3.f.

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Stanton, Amelia M., Abigail W. Batchelder, Norik Kirakosian, James Scholl, Dana King, Chris Grasso, Jennifer Potter, Kenneth H. Mayer, and Conall O’Cleirigh. "Differences in mental health symptom severity and care engagement among transgender and gender diverse individuals: Findings from a large community health center." PLOS ONE 16, no. 1 (January 25, 2021): e0245872. http://dx.doi.org/10.1371/journal.pone.0245872.

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Mental health disparities among transgender and gender diverse (TGD) populations have been documented. However, few studies have assessed differences in mental health symptom severity, substance use behavior severity, and engagement in care across TGD subgroups. Using data from the electronic health record of a community health center specializing in sexual and gender minority health, we compared the (1) severity of self-reported depression, anxiety, alcohol use, and other substance use symptoms; (2) likelihood of meeting clinical thresholds for these disorders; and (3) number of behavioral health and substance use appointments attended among cisgender, transgender, and non-binary patients. Participants were 29,988 patients aged ≥18 who attended a medical appointment between 2015 and 2018. Depression symptom severity (F = 200.6, p < .001), anxiety symptom severity (F = 102.8, p < .001), alcohol use (F = 58.8, p < .001), and substance use (F = 49.6, p < .001) differed significantly by gender. Relative to cisgender and transgender individuals, non-binary individuals are at elevated risk for depression, anxiety, and substance use disorders. Gender was also associated with differences in the number of behavioral health (χ2 = 51.5, p < .001) and substance use appointments (χ2 = 39.3, p < .001) attended. Engagement in treatment among certain gender groups is poor; cisgender women and non-binary patients assigned male at birth were the least likely to have attended a behavioral health appointment, whereas transgender men and cisgender women had attended the lowest number of substance use appointments. These data demonstrate the importance of (1) assessing gender diversity and (2) addressing the barriers that prevent TGD patients from receiving affirming care.

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Donnelly, Joseph, Michael Young, Rebecca Pearson, Tina M. Penhollow, and Aida Hernandez. "Area Specific Self-Esteem, Values, and Adolescent Substance Use." Journal of Drug Education 38, no. 4 (December 2008): 389–403. http://dx.doi.org/10.2190/de.38.4.f.

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Chepurnov, S. A., N. E. Chepurnova, E. Paschali, N. Yu Panteleev, and I. P. Ashmarin. "Substance P and brain functional lateralization." Regulatory Peptides 37 (September 1992): S45. http://dx.doi.org/10.1016/0167-0115(92)90900-f.

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Garkushin, Ivan K., Mariya A. Istomova, Alexey I. Garkushin, and Gennadiy E. Egortsev. "CHEMICAL INTERACTION IN MIXTURES МF + NaBr (М – K, Rb, Cs) UNDER THERMAL ACTIVATION." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 63, no. 4 (April 17, 2020): 55–62. http://dx.doi.org/10.6060/ivkkt.20206304.6159.

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The chemical interaction of equivalent amounts of MF+NaBr (M – K, Rb, Cs) was studied by differential thermal and X-ray phase analysis. A mechanism of interaction during thermal activation is proposed, including the formation of NaF+MBr products at the contact boundaries of the initial substance grains due to the diffusion of Na+ and M+ followed by contact melting of four substances that form a labile liquid phase below or equal to the melting points of low-melting triple eutectics. The labile liquid occurrence in the sample promotes rapid ionic interaction. The heating curves of equivalent amounts of two substance powdered mixtures corresponding to the unstable diagonals of triple irreversibly reciprocal systems made it possible to obtain data on the appearance of the liquid phase, the onset of exothermic reactions (the melting points of low melting eutectics), the melting temperatures of quasibinary eutectics on stable diagonals, and the melting temperatures of the mixtures. The crystallization of molten mixtures of equivalent amounts of two unstable substances of triple irreversibly reciprocal systems made it possible to determine the liquidus temperature at the point of complete conversion and the temperature of the crossing point on a stable diagonal. Therefore, the heating and cooling curves analysis provides information on the melting points of low-melting triple eutectics (570, 508 and 430 °C), the temperatures of the pass points (654, 644 and 606 °С) and the melting temperatures of the compositions corresponding to the full conversion points (798, 845 and ~840 °C) in the Na+,K+||F–,Br–, Na+,Rb+||F–,Br–, and Na+,Cs+||F–,Br– systems, respectively. Powdered substances exchange reactions can be used as low-potential exothermic compounds, as fuses, which turn off various reactors or plants when the liquid phase appears, and for the synthesis of inorganic substances.

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Tisne-Versailles, J., C. Masse, R. Bonnafous, A. M. Bessac, A. Marty, Y. Verscheure, and A. Sassine. "Cardiovascular pharmacology of a new anti-isdiaemic substance: F 3226." European Journal of Pharmacology 183, no. 3 (July 1990): 799–800. http://dx.doi.org/10.1016/0014-2999(90)92610-u.

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Mutryarny, Enny, and Seprita Lidar. "RESPON TANAMAN PAKCOY (Brassica rapa L) AKIBAT PEMBERIAN ZAT PENGATUR TUMBUH HORMONIK." Jurnal Ilmiah Pertanian 14, no. 2 (March 15, 2018): 29–34. http://dx.doi.org/10.31849/jip.v14i2.258.

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This study aims to know effect and find the best concentrate of Hormonik growing regulatory substances the growth and production of plants Pakcoy. The research was carried out in Complete Random design experiments (RAL) with 5 degrees of treatment with 4 replicates with parameters of observation is the height of plants, number of leaves, leaf width and heavy consumption. The data were analyzed statistically observations with prints, when F Count greater than or equal to F table 5%, followed by the test distance double Duncan in standard of 5%. The giving substance to a regulator grew Hormonikcan increase the growth and production of plants Pakcoy, with the best concentration is 4 cc/l water, it is advisable to further research with increased concentrations of Hormonik growing regulatory substances.

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Haug, Nancy A., Michael Shopshire, Barbara Tajima, Valerie Gruber, and Joseph Guydish. "Adoption of Evidence-Based Practices among Substance Abuse Treatment Providers." Journal of Drug Education 38, no. 2 (June 2008): 181–92. http://dx.doi.org/10.2190/de.38.2.f.

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Igwe, O. J., X. Sun, and A. A. Larson. "Correlation of substance P-induced desensitization with substance P amino terminal metabolites in the mouse spinal cord." Peptides 11, no. 4 (July 1990): 817–25. http://dx.doi.org/10.1016/0196-9781(90)90199-f.

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Behrendt, S., H. U. Wittchen, M. Hoefler, R. Lieb, and K. Beesdo. "P.6.f.002 High-risk phases for first substance use, transition to regular substance use and substance use disorders in adolescence." European Neuropsychopharmacology 18 (August 2008): S552—S553. http://dx.doi.org/10.1016/s0924-977x(08)70840-x.

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Madell, Geoffrey. "The Road to Substance Dualism." Royal Institute of Philosophy Supplement 67 (July 7, 2010): 45–60. http://dx.doi.org/10.1017/s1358246110000111.

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AbstractThe common materialist view that a functional account of intentionality will eventually be produced is rejected, as is the notion that intentional states are multiply realisable. It is argued also that, contrary to what many materialists have held, the causation of behaviour by intentional states rules out the possibility of a complete explanation of human behaviour in physical terms, and that this points to substance dualism. Kant's criticism of the Cartesian self as a substance, endorsed by P. F. Strawson, rests on a misinterpretation of Descartes. The so-called ‘causal pairing problem’, which Kim sees to be the crucial objection to substance dualism, is examined, and Kim's arguments are rejected.

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Karatay, Gülnaz, and Nazan Gürarslan Baş. "Effects of Role-Playing Scenarios on the Self-efficacy of Students in Resisting Against Substance Addiction: A Pilot Study." INQUIRY: The Journal of Health Care Organization, Provision, and Financing 54 (January 1, 2017): 004695801772062. http://dx.doi.org/10.1177/0046958017720624.

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During the first phases of adolescent development, young people have little self-efficacy and resistance against substance use. The aim of this study was to demonstrate the effectiveness of role-playing scenarios on the self-efficacy of students in resisting substance use. A pre test and post test study design was used with a single group. The study was carried out with 245 secondary school students. The scenario-based training, developed by the researchers, was presented by the school counselors once a week for 4 weeks. For this purpose, a booklet of scenarios was prepared for the teachers. The role-playing scenarios were intended to improve adolescents’ abilities to say “no” to substance offers, to prevent them from becoming addicted to certain substances, and to call for help if needed. The data of the study were collected using the Personal Information Form and the Self-Efficacy for Adolescences Protecting Substance Abuse Scale . The obtained data were assessed using percentages, chi-square, t test, and F test in the SPSS software. Results showed that, after the training, the mean score in the Self-Efficacy for Adolescences Protecting Substance Abuse Scale increased significantly (103.20 ± 20.00) compared with before the training (92.11 ± 17.08) ( P < .05). Short-term outcomes of the class-based scenario training were observed to be effective in the development of students’ self-efficacy to resist the temptations of substance use.

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Brereton, Kate L., Josefina Álvarez, Leonard A. Jason, Edward B. Stevens, Vida B. Dyson, Catherine Mcneilly, and Joseph R. Ferrari. "Reciprocal Responsibility and Social Support among Women in Substance Use Recovery." International Journal of Self Help and Self Care 8, no. 2 (January 1, 2014): 239–57. http://dx.doi.org/10.2190/sh.8.2.f.

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Dunn, Michael S., Bruce Behringer, Kristine H. Bowers, and Randall E. Jessee. "Evaluation of a Community Approach to Address Substance Abuse in Appalachia." International Quarterly of Community Health Education 30, no. 2 (June 20, 2010): 171–83. http://dx.doi.org/10.2190/iq.30.2.f.

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Oye-Adeniran, B. A., O. F. Aina, A. Gbadegesin, and E. E. Ekanem. "Substance Use and Sexual Behaviour among Female Students in Nigerian Universities." International Quarterly of Community Health Education 35, no. 1 (November 21, 2014): 73–83. http://dx.doi.org/10.2190/iq.35.1.f.

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Mu, Rui, and Na Zhao. "Design for Disassembly Based on Substance-Field Analysis." Applied Mechanics and Materials 527 (February 2014): 105–10. http://dx.doi.org/10.4028/www.scientific.net/amm.527.105.

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As a part of sustainable product design, design for disassembly is critical for maintaining competitiveness of manufacturers. The conflicts between disassembly capability and functionality and reliability need to be addressed innovatively and effectively. This article proposes a method to combine functional analysis and substance-field(S-F) analysis adapted from TRIZ to solve such complex conflicts. First, problems of current design that hinder the disassembly capability of products are identified. Second, functional and cause analysis are carried out for the technical system to transform conceptual description into practical description for components in the technical system. Last, a solution for improving the disassembly capability of products is proposed based on the structural model obtained from S-F analysis. This method is used to improve the disassembly capability of couplings in automotive transmissions, and proven to be effective and feasible in discovering an innovative solution.

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Dietch, Jessica, Norah Simpson, Joshua Tutek, Isabelle Tully, Elizabeth Rangel, and Rachel Manber. "373 Historical Use of Substances for Insomnia Impacts Current Beliefs about Hypnotic Medications." Sleep 44, Supplement_2 (May 1, 2021): A148—A149. http://dx.doi.org/10.1093/sleep/zsab072.372.

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Abstract Introduction The purpose of the current study was to examine the relationship between current beliefs about hypnotic medications and historical use of prescription hypnotic medications or non-prescription substances for sleep (i.e., over the counter [OTC] medications, alcohol, and cannabis). Methods Participants were 142 middle age and older adults with insomnia (M age = 62.9 [SD = 8.1]; 71.1% female) enrolled in the RCT of the Effectiveness of Stepped-Care Sleep Therapy In General Practice (RESTING) study. Participants reported on history of substances they have tried for insomnia and completed the Beliefs about Medications Questionnaire-Specific with two subscales assessing beliefs about 1) the necessity for hypnotics, and 2) concerns about potential adverse consequences of hypnotics. Participants were grouped based on whether they had used no substances for sleep (No Subs, 11.6%), only prescription medications (Rx Only, 9.5%), only non-prescription substances (NonRx Only, 26.6%), or both prescription and non-prescription substances (Both, 52.3%). Results Sixty-one percent of the sample had used prescription medication for sleep and 79% had used non-prescription substances (74% OTC medication, 23% alcohol, 34% cannabis). The greater number of historical substances endorsed, the stronger the beliefs about necessity of hypnotics, F(1,140)=23.3, p<.001, but not about concerns. Substance groups differed significantly on necessity beliefs, F(3,1)=10.68, p<.001; post-hocs revealed the Both group had stronger beliefs than the No and NonRx Only groups. Substance groups also differed significantly on the concerns subscale, F(3,1)=6.68, p<.001; post-hocs revealed the NonRx Only group had stronger harm beliefs than the other three groups. Conclusion The majority of the sample had used both prescription and non-prescription substances to treat insomnia. Historical use of substances for treating insomnia was associated with current beliefs about hypnotics. Individuals who had used both prescription and non-prescription substances for sleep in the past had stronger beliefs about needing hypnotics to sleep at present, which may reflect a pattern of multiple treatment failures. Individuals who had only tried non-prescription substances for sleep may have specifically sought alternative substances due to concerns about using hypnotics. Future research should seek to understand the impact of treatment history on engagement in and benefit from non-medication-based treatment for insomnia. Support (if any) 1R01AG057500; 2T32MH019938-26A1

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Patton, G. C. "Puberty and the Onset of Substance Use and Abuse." PEDIATRICS 114, no. 3 (September 1, 2004): e300-e306. http://dx.doi.org/10.1542/peds.2003-0626-f.

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Okamoto, Ryohei, and Akihiko Kumai. "Antigonadotropic activity of hop extract." Acta Endocrinologica 127, no. 4 (October 1992): 371–77. http://dx.doi.org/10.1530/acta.0.1270371.

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Biological activity of water soluble fractions F-1 and F-2, which were extracted from hop, was studied and its action mechanism was speculated using the immature female sd rats. Administration of the substance significantly inhibited the effects of pregnant mare serum gonadotropin (PMSG) on 22-day-old female rats. Thus, PMSG-induced increases in ovarian weight, estrogen secretion, number of ovulated egg, progesterone production, uterine thymidine kinase activity, and plasma LH level were suppressed significantly. Furthermore, addition of the substance to incubated ovarian cells of the second day after PMSG injection resulted in suppression of FSH-induced estradiol secretion in vitro, probably via cAMP-dependent mechanism. But addition of the substance to incubated pituitary cells from ovariectomized rats did not change in LH secretion.

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Drymalski, Walter Matthew. "Expanding the use of the ASAM CriteriaTM to make mental health level of care placements." Advances in Dual Diagnosis 11, no. 2 (May 21, 2018): 49–59. http://dx.doi.org/10.1108/add-10-2017-0020.

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Purpose Despite the prevalence of co-occurring mental health and substance use disorders, the assessment and placement processes for each often remain separate. The purpose of this paper is to describe an expanded use of the American Society of Addiction Medicine (ASAM) CriteriaTM to make placements into substance use, co-occurring, and mental health treatment. Design/methodology/approach A rationale for the development of two new domains (Domain 7, substance use and Domain 8, independent living skills) and preliminary data supporting the use of the ASAM CriteriaTM as a placement process for all types of behavioral health issues will be provided. Findings Dimension 3 and Domains 7 and 8 were correlated with selected clinical indices in the expected direction (Dimension 3: depression (F (4, 4650)=202.092, p<0.001), medication usage (F (4, 4,637)=174.254, p<0.001), and psychotic symptoms (F (4, 4,561)=62.954, p<0.001); Domain 7: alcohol use (F (4, 4,458)=213.786, p<0.001) and drug use (F (4, 4,471)=611.491, p<0.001); and Domain 8: functional impairment (F (4, 3,927)=815.646, p<0.001) and number of “high needs” (F (4, 3,927)=737.568, p<0.001). Research limitations/implications The limitations of this research included a lack of inter-rater reliability data and less established intake assessments. Practical implications This single placement approach for clients seeking behavioral health services can create a more efficient, person-centered intake experience. Originality/value This paper suggests that it is possible to deploy a single assessment and placement approach for all types of behavioral health issues.

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Dadich, Ann. "Expanding Our Understanding of Self-Help Support Groups for Substance Use Issues." Journal of Drug Education 40, no. 2 (June 2010): 189–202. http://dx.doi.org/10.2190/de.40.2.f.

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L. Benkendorf, Judith. "Prenatal substance abuse: A ubiquitous cry for help." Reproductive Toxicology 5, no. 2 (January 1991): 87–88. http://dx.doi.org/10.1016/0890-6238(91)90036-f.

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Zauszniewski, Jaclene A. "Severity of Depression, Cognitions, and Functioning Among Depressed Inpatients With and Without Coexisting Substance Abuse." Journal of the American Psychiatric Nurses Association 1, no. 2 (April 1995): 55–60. http://dx.doi.org/10.1177/107839039500100205.

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BACKGROUND: Investigators have proposed that the cognitive-bebavioral patterns of persons with the dual diagnoses of depression and substance abuse differ from those of persons with only one of the disorders. However, researchers have not investi gated these differences. OBJECTIVE: This study examined differences in severity of depression, cognitions, and adaptive functioning among depressed persons with and without coexisting substance abuse. DESIGN: A cross-sectional design was used to compare depressed adult inpatients with (n = 31) and without (n = 32) coexisting substance abuse. RESULTS: Although both groups were found to be moderately depressed and limited in their functional ability, the dual diagnosis group was more severely depressed (F(1,60) = 4.05; p = .05), more limited in functioning (F(1,60) = 3.52; p = .07), and reported more depressive cognitions (F(1,60) = 7. 72; p =.01). The groups were similar in se verity of depression and adaptive functioning when the effects related to the depres sive cognitions were statistically controlled. CONCLUSION: The findings support the importance of using nursing interventions that involve cognitive restructuring to assist persons with the dual diagnoses of depressive illness and substance abuse to change their maladaptive ways of thinking to more healthy and adaptive thought processes. (JAM PSYCHIATR NURSES Assoc [1995]. 1, 55-60)

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Gurung, Deepa, Bindu Thapa, and Amrita Paudel. "Prevalence of Substance Use Disorders and Effectiveness of Educational Package on Knowledge Regarding the Disorders among Adolescents in Selected Schools of Lekhnath, Nepal." International Journal of Innovative Science and Research Technology 5, no. 7 (August 6, 2020): 934–41. http://dx.doi.org/10.38124/ijisrt20jul617.

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Substance use disorders refers to the abuse of alcohol, illicit drugs, or substances such as over-thecounter medicines, medicines from unsupervised ordinary retail purchase, or even through prescription. It causes significant health problems and functional impairments such as disability and failure to meet responsibilities at work, school, or home. Common substance use disorders are use of alcohol, tobacco, cannabis (marijuana), stimulants, hallucinogens, sedatives, hypnotics, opioids, etc. Objective: To assess prevalence of substance use disorders and effectiveness of educational package on spreading knowledge about substance use disorders among adolescents in selected schools in Lekhnath, Nepal. Methodology: Pre experimental one group pretest and posttest design was used for the study. Non-probability convenience sampling technique was adopted for sampling. For the study, total of 155 adolescents studying in classes 9 and 10 were selected from schools in Lekhnath, Nepal. Self administered structured questionnaire was used to collect data. Data obtained were entered in Microsoft Excel and analyzed using statistical tool SPSS 16.0.  Result: Among 155 adolescents, 97.40% had heard of substance use disorders. 62.24% of people received the information about substance use disorders via mass media. Family members of 16.8% of samples were engaged in some kind of substance use disorders. 1.90% of sample students drank alcohol, who all happened to be male of age 15-16 years age group. In pretest, more than half (69.70%) of the adolescents had inadequate knowledge about substance use disorders. On the other hand, in the posttest, more than one third of adolescents (37.4%) had adequate knowledge and less than twothird adolescents (58.1%) had moderate knowledge on substance use disorders. The paired ‘t’ test was found to be significant on knowledge level (t=23.76 at 1% level).Only caste/ethnicity of demographical variable was found to be associated with pretest knowledge regarding substance use disorders (F= 3.495 at 5% level, p=0.033). Conclusion: The study concluded that adolescents are in great risk for substance use disorders. After educating on substance use disorders, adolescents gained adequate knowledge regarding the disorder. Study supports that educational package was effective in improving the level of knowledge regarding substance use disorders among adolescents

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Skidgel, Randal A., Herbert L. Jackman, and Ervin G. Erdös. "Metabolism of substance P and bradykinin by human neutrophils." Biochemical Pharmacology 41, no. 9 (May 1991): 1335–44. http://dx.doi.org/10.1016/0006-2952(91)90106-f.

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Batlle, E., T. Fern´andez, V. Giron`es, J. Martínez, I. Rivas, and C. Romero. "P.6.f.002 Duloxetine in depressed patients with comorbid substance abuse." European Neuropsychopharmacology 17 (October 2007): S564—S565. http://dx.doi.org/10.1016/s0924-977x(07)70878-7.

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Kirisci, Levent, Maureen Reynolds, and Ralph Tartar. "Quick Screen to Detect Current and Future Substance Use Disorder in Adolescent Females." International Journal of Person Centered Medicine 3, no. 4 (May 12, 2014): 280–85. http://dx.doi.org/10.5750/ijpcm.v3i4.414.

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Background. Prevention of substance use disorder (SUD) is impeded by the large number, complexity and idiosyncratic configuration of etiological factors. Effective prevention of SUD is feasible however when intervention resources are prioritized to individuals who are objectively determined high risk and tailored to their specific characteristics and circumstances.Objective. This study had the aim of developing a rapid accurate screening instrument for determining current presence of and future risk for SUD. Methods. The sample consisted of 182 girls recruited when they were 10-12 years of age and tracked to 22 years of age. From a large item pool the Drug Use Screening Inventory Quick Screen for Females (DQS-F) was derived consisting of the Substance Involvement Index and the Problem Severity Index.Results. The DQS for Females (DQS-F) has high sensitivity for identifying girls who currently qualify for SUD diagnosis. Furthermore, accuracy of predicting future SUD with the DQS-F is in the good range at age 16 and in the very good range at age 19.Conclusions. Requiring only three minutes for administration on the Web the DQS-F is an efficient method for identifying girls requiring thorough assessment prior to implementing individualized intervention.

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FRICOURT, BEATRICE V., SUSAN F. BAREFOOT, ROBERT F. TESTIN, and STEVEN S. HAYASAKA. "Detection and Activity of Plantaricin F an Antibacterial Substance from Lactobacillus plantarum BF001 Isolated from Processed Channel Catfish." Journal of Food Protection 57, no. 8 (August 1, 1994): 698–702. http://dx.doi.org/10.4315/0362-028x-57.8.698.

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Lactobacillus plantarum BF001 isolated from chilled processed channel catfish produced an antimicrobial substance active against selected bacteria from the genera Lactobacillus, Lactococcus, Listeria, Micrococcus, Leuconostocs, Pediococcus, Staphylococcus, Streptococcus, Salmonella and Pseudomonas. The antimicrobial effect did not result from acidic fermentation products or hydrogen peroxide. Culture extracts showed a bactericidal mode of action, displayed optimal activity at pH 3.5, and retained full activity after 30 min at 100°C (pH 3.5). It was not conclusively proved that the substance, named plantaricin F, was sensitive to proteolytic enzymes. Its molecular weight was estimated by ultrafiltration studies to be under 10,000 daltons. The ability of plantaricin F to inhibit a wide-range of bacteria, including gram-positive and gram-negative foodborne pathogens, is of potential interest for food safety, and plantaricin F may have future applications as a food preservative.

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Bodempudi, Suresh Babu, Ravi Chandra Babu Rupakula, Konda S. Reddy, and Mahesh Reddy Ghanta. "ISOLATION, CHARACTERIZATION AND VALIDATION OF HPLC METHOD FOR QUANTIFICATION OF BIS-[10-(2-METHYL-4H-3-THIA-4,9-DIAZABENZO[F]AZULENE)]-1,4-PIPERAZINE IN AN ANTI-PSYCHOTIC DRUG SUBSTANCE, OLANZAPINE." International Journal of Current Pharmaceutical Research 10, no. 4 (July 16, 2018): 22. http://dx.doi.org/10.22159/ijcpr.2018v10i4.28454.

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Objective: The main objective of present study was to Isolate, characterize and validate a reverse phase high performance liquid chromatographic method was validated for quantification of bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene)]-1,4-piperazine in Olanzapine drug substance; it decreases the mental disorders in human body. The method is specific, rapid, precise and accurate for the separation and determination of bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene)]-1,4-piperazine in Olanzapine drug substance form.Methods: The bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene)]-1,4-piperazine of Olanzapine was resolved on a Zorbax RX-C 8, 250 mm X 4.6 mm, 5 micron column (L-1) using a mobile phase system containing 0.03 M sodium dodecyl sulphate in water pH 2.5 with 1 N sodium hydroxide solution and acetonitrile in the ratio of (Mobile phase A-52:48 v/v) and (Mobile phase B-buffer and Acetonitrile 30:70 v/v) by using the gradient program. The mobile phase was set at a flow rate of 1.5 ml/min and the volume injected was 20μl for every injection. The detection wavelength was set at 220 nm and the column temperature was set at 35 °C.Results: The proposed method was productively applied for the quantitative determination of bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo [f]azulene)]-1,4-piperazine in Olanzapine drug substance form. The linear regression analysis data for calibration plots showed a good linear relationship over a concentration range of 0.025to 0.903 µg/ml for bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene)]-1,4-piperazine, 0.081-0.608 µg/ml for Olanzapine. The mean values of the correlation coefficient were 0.999 and 0.999 for bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene)]-1,4-piperazine and Olanzapine. The method was validated as per the ICH guidelines. The detection limit (LOD) was about 0.007 µg/ml, 0.024 µg/ml and quantitation limit (LOQ) was about 0.024 µg/ml, 0.081 µg/ml for bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene)]-1,4-piperazine and Olanzapine. The relative standard deviation was found to be 1.64 % and 2.18 % for bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene)]-1,4-piperazine and Olanzapine.Conclusion: The validated HPLC method and the statistical analysis showed that the method is repeatable and selective for the estimation of the bis-[10-(2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene)]-1,4-piperazine of the Olanzapine drug substance.

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Kostowski, W., and J. Beck. "P.6.f.001 Is drive satisfaction mechanism (“antidrive”) involved in substance addiction?" European Neuropsychopharmacology 16 (January 2006): S521—S522. http://dx.doi.org/10.1016/s0924-977x(06)70719-2.

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Zagar, Robert John, Steve Variela, William M. Grove, Kenneth G. Busch, James Garbarino, Agata Karolina Zagar, Joseph W. Kovach, Steve Tippins, John Russell Hughes, and Ishup Singh. "Implications of Machine-Learning, Internet-Tests to Save Lives and Money: "7-Point Violence Profile:" Review of 212 Studies, 320,051 Persons, Over 95 Years, With a Cross-Validation Among 136 Homicidal, Overdosing- Substance-Abusing, Sex-Offending,." Review of European Studies 11, no. 1 (February 15, 2019): 106. http://dx.doi.org/10.5539/res.v11n1p106.

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Analysis of 136 persons with psychopathology, suicidal ideation, and violence included: (a) 79 adults [12 homicidal, 13 overdosing-substance-abusers, 15 sex-offending, 15 suicide-completers, 24 controls (23 women, 56 men) Mage=38.29]; and (b) 57 teens [11 homicidal, 7 overdosing-substance-abusers, 10 sex-offending, 17 suicide-completers, 12 controls (15 girls, 42 boys) Mage= 15.37] given (Standard Predictor of Violence Potential (SP), Quick Test (QT), Beck Scale (BSS), MMPI-2/A, Raven Matrices). Significant (p < .05) ANOVA Fs were: (a) adults (SP, BSS, MMPI-2 [VRIN, F, FB, FP, L, K, S, Hs (1), D (2), Pd (4), Mf (5), Pa(6), Pt(7), Sc (8), Ma (9), Si (10), MAC-R, APS, AAS], Raven; and (b) teens (SP, BSS, MMPI-A [F1, F, L, K, D (2), Pa (6), Sc (8)], QT. At-risk, adults, and teens had the same “7-point violence profile” (SP -, “F/L-2-4-6-8-AAS(ACK)”) [insignificant differences (p < .05) ANOVA-Fs: SP, BSS, MMPI-2/A: F, L, K, D (2), Pd (4), Pa (6), Sc (8)].

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Ahmed, Mahmood, Anders Bjurholm, Gopala Rao Srinivasan, Tomas Lundeberg, Elvar Theodorsson, Marianne Schultzberg, and Andris Kreicbergs. "Capsaicin effects on substance P and CGRP in rat adjuvant arthritis." Regulatory Peptides 55, no. 1 (January 1995): 85–102. http://dx.doi.org/10.1016/0167-0115(94)00095-f.

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Gilcrease, Michael Z., and Richard L. Hoover. "Secretion of a chemotactic substance(s) by AGE-stimulated human monocytes." Diabetes Research and Clinical Practice 16, no. 1 (April 1992): 7–11. http://dx.doi.org/10.1016/0168-8227(92)90129-f.

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Sevian, Hannah, and Steven Couture. "Epistemic games in substance characterization." Chemistry Education Research and Practice 19, no. 4 (2018): 1029–54. http://dx.doi.org/10.1039/c8rp00047f.

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Problem solving is lauded as beneficial, but students do not all learn well by solving problems. Using the resources framework, Tuminaro J., and Redish E. F., (2007), Elements of a cognitive model of physics problem solving: Epistemic games,Physical Review Special Topics-Physics Education Research,3(2), 020101 suggested that, for physics students, this puzzle may be partially understood by paying attention to underlying epistemological assumptions that constrain the approaches students take to solving problems while working on them. They developed an approach to characterizing epistemic games, which are context-sensitive knowledge elements concerning the nature of knowledge, knowing and learning. As there is evidence that context-activated knowledge influences problem solving by students in chemistry, we explored identifying epistemic games in students’ problem solving in chemistry. We interviewed 52 students spanning six courses from grade 8 through fourth-year university, each solving 4 problems. Using 16 contexts with substance characterization problems, we identified 5 epistemic games with ontological and structural stability that exist in two larger epistemological frames. All of these epistemic games are present at all educational levels, but some appear to grow in across educational levels as others recede. Some games also take lesser and greater precedence depending on the problem and the chemistry course in which students are enrolled and the context of the problem. We analyze these results through a frame of learning progressions, paying attention to students’ ideas and how these ideas are contextualized. Based on this analysis, we propose teaching acts that instructors may use to leverage the natural progressions of how students appear to grow in their capacity to solve problems.

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Pardede, Winda Ningsih, Gusti Muhammad Hatta, and Damaris Payung. "PENGARUH BERBAGAI ZAT PENGATUR TUMBUH (ZPT) TERHADAP PERTUMBUHAN STEK BATANG PULAI RAWA (Alstonia spatulata)." Jurnal Sylva Scienteae 4, no. 2 (April 26, 2021): 198. http://dx.doi.org/10.20527/jss.v4i2.3329.

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Some of the goals that exist in this research are to analyze how the effect of giving Rootone F, giving Rootmost and giving Bean Sprouts Extract to the growth response of stem cuttings in Pulai Rawa (Alstonia spatulata. Growth Regulatory Substances used in this study there are 3 types of treatments such as giving Rootone F as the first treatment, the second treatment is by giving rootmost and by giving Bean Sprouts Extract as the third treatment and in this study there is control as one of the comparison between the differences between Stem cuttings that use Growth Regulatory Substances with no provision of ZPT. In November 2019 until January 2020 this study took place in the shade house of the forestry faculty at Lambung Mangkurat University. RAL (Completely Randomized Design) The method used in this study is to use with a set of 4 treatments that were repeated 20 times in each treatment, then there were 80 experimental units in this study. The results obtained in this study showed the effect of various growth regulators which differed to the response of the growth of Pulai Rawa plant stem cuttings. The provision of rootone F did not affect the growth response while the administration of Growth Regulator Substance Rootmost gave an effect on the response of root growth of Pulai Rawa cuttings (Alstonia spatulata) and by giving Bean Sprout Extract which had an influence on the growth in number of cuttings.Keywords : Growth regulators; Stem cuttings; Pulai Rawa

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Siragy, H. M., R. A. Felder, N. L. Howell, R. L. Chevalier, M. J. Peach, and R. M. Carey. "Evidence that intrarenal dopamine acts as a paracrine substance at the renal tubule." American Journal of Physiology-Renal Physiology 257, no. 3 (September 1, 1989): F469—F477. http://dx.doi.org/10.1152/ajprenal.1989.257.3.f469.

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Dopamine is synthesized within the kidney and dopamine 1 (DA1) receptors are associated with the proximal tubule. In pharmacological doses, dopamine increases renal blood flow and sodium excretion. It is possible that dopamine formed intrarenally acts locally via renal dopamine receptors to control renal function. We investigated the possible paracrine action of renal dopamine by intrarenal administration of a specific DA1 antagonist, Sch 23390, in doses confined to the kidney in conscious uninephrectomized dogs (n = 5) in metabolic balance at a sodium intake of 40 meq/day. Changes (mean +/- SE) in renal excretory and hemodynamic function in response to cumulative infusions of several doses of Sch 23390 (0.01, 0.1, 1.0, 5.0, and 10.0 pmol.kg-1.min-1) were studied. Sch 23390 at 0.01 pmol.kg-1.min-1 did not cause any changes in urinary flow rate or sodium excretion. Sch 23390 in doses from 0.1 to 10.0 mol.kg-1.min-1 caused a significant dose-dependent antidiuresis (F = 44.9, P less than 0.0001) and antinatriuresis (F = 42.1, P less than 0.0001) and a decrease in fractional sodium excretion (F = 44.2, P less than 0.0001). No changes in estimated renal plasma flow, glomerular filtration rate, plasma aldosterone concentration, plasma renin activity, or systemic arterial pressure occurred with any dose of intrarenal Sch 23390 infused into the renal artery. Rebound diuresis and natriuresis occurred after cessation of the DA1 blockade.(ABSTRACT TRUNCATED AT 250 WORDS)

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Rameshwar, Pranela, Pedro Gascon, and Doina Ganea. "Immunoregulatory effects of neuropeptides. Stimulation of interleukin-2 production by substance P." Journal of Neuroimmunology 37, no. 1-2 (March 1992): 65–74. http://dx.doi.org/10.1016/0165-5728(92)90156-f.

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Entinzon, I. R., and E. V. Isarova. "Simulation of electron transmission through a substance taking into account multiple scattering." Radiation Physics and Chemistry 46, no. 1 (July 1995): 3–9. http://dx.doi.org/10.1016/0969-806x(95)90580-f.

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Wessendorf, M. W., S. J. Tallaksen-Greene, and R. M. Wohlhueter. "A spectrophotometric method for determination of fluorophore-to-protein ratios in conjugates of the blue fluorophore 7-amino-4-methylcoumarin-3-acetic acid (AMCA)." Journal of Histochemistry & Cytochemistry 38, no. 1 (January 1990): 87–94. http://dx.doi.org/10.1177/38.1.1688452.

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7-Amino-4-methylcoumarin-3-acetic acid (AMCA) has been found to be a useful fluorophore for immunofluorescence. The present study describes a spectrophotometric method for determining the ratio of moles AMCA to moles protein (or the f/p ratio) in an AMCA-conjugated IgG. The concentration of a substance absorbing light can be determined spectrophotometrically using Beer's Law: Absorbance = Concentration x Extinction coefficient. From Beer's law, one can derive the following formula for determining the f/p ratio of AMCA-IgG conjugates: f/p = (epsilon 280IgG).A350 - (epsilon 350IgG).A280/(epsilon 350AMCA).A280 - (epsilon 280AMCA).A350 where A is the optical density of the conjugate at the given wavelength and epsilon is the extinction coefficient of a substance at the wavelength specified. Using conjugates of model proteins, it was found that the extinction coefficients of the AMCA moiety of AMCA-conjugated protein were 1.90 x 10(4) at 350 nm and 8.29 x 10(3) at 280 nm. Similarly, it was found that the extinction coefficients of swine IgG were 1.56 x 10(3) at 350 nm and 1.26 x 10(5) at 280 nm. Thus, for AMCA-conjugated swine IgG: f/p = (1.26 x 10(5)).A350 - (1.56 x 10(3)).A280/(1.47 x 10(4)).A280 - (6.42 x 10(3)).A350 [corrected]. Based on this formula, the f/p ratios of some AMCA-IgG conjugates useful for immunohistochemistry have been found to range between 6 and 24.

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Martinez Riera, R., G. Mateu Codina, C. Castillo buenaventura, M. G. Hurtado Ruiz, J. Martí Bonany, R. Sanchez Gonzalez, and M. Torrens Melich. "P.3.f.003 Gender differences in psychosis with co-occurring substance use disorder." European Neuropsychopharmacology 24 (October 2014): S567. http://dx.doi.org/10.1016/s0924-977x(14)70908-3.

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Sio, Selena, Jia Lu, Shabbir Moochhala, and Madhav Bhatia. "F.77. A Key Role of Substance P in Acute Lung Injury After Burn." Clinical Immunology 131 (2009): S114. http://dx.doi.org/10.1016/j.clim.2009.03.335.

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Hosoe, Tomoo, Tatsuya Sano, Hideo Nishikawa, Koohei Nozawa, Ken-ichi Kawai, Yuichi Yamaoka, Keizo Katsuya, Tsuyoshi Sato, Hiroshi Hagiwara, and Hatsuo Saito. "A substance inducing teliospore production in wheat leaf rust, Puccinia recondita f. sp. tritici." Mycoscience 42, no. 3 (June 2001): 241–45. http://dx.doi.org/10.1007/bf02463914.

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Renbarger, Kalyn M., Margaret Moorman, Kenzie Latham-Mintus, Carol Shieh, and Claire Draucker. "Factors Associated With a Trusting Relationship Between Pregnant and Postpartum Women With Substance Use Disorders and Maternity Nurses." International Journal of Childbirth 10, no. 4 (December 1, 2020): 180–97. http://dx.doi.org/10.1891/ijcbirth-d-20-00018.

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Trusting relationships between pregnant and postpartum women with substance use disorders (SUDs) and maternity nurses can improve health outcomes for women and their infants. This study was conducted to identify factors associated with the formation of trust in these nurse–patient relationships. Using a qualitative description approach, semi-structured interviews were conducted with 10 women who used substances during pregnancy and 15 maternity nurses. The narratives were analyzed with standard content analytic techniques. Findings revealed that six characteristics of nurses and five characteristics of women fostered or hindered the formation of trusting relationships. The characteristics of the maternity nurses were (a) interpersonal connections, (b) demeanor toward women, (c) ways of providing care, (d) approaches to providing information, (e) attitudes toward substance use, and (f) addiction expertise. The characteristics of the women were (a) engagement with nurses, (b) demeanor toward nurses, (c) attitudes toward care, (d) investment in recovery, and (e) ways of interacting with infant. The characteristics provide a framework by which maternity nurses can examine their attitudes and behaviors toward women with SUDs and inform the development of strategies to enhance their practice with this population.

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Martinotti, G., C. Montemitro, M. Corbo, F. Sarchione, E. Cinosi, A. Pasquini, V. Mancini, and C. Merino del Villar. "Use of Novel Psychoactive Substances and Induced Psychiatric Symptoms: Outcomes From the Eivissa Project." European Psychiatry 41, S1 (April 2017): S206. http://dx.doi.org/10.1016/j.eurpsy.2017.01.2164.

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IntroductionPolydrug abuse seems to be especially popular in Ibiza, an important market for new psychoactive substances (NPS). The misuse of psychoactive substances can lead to serious psychiatric symptoms.AimsTo evaluate symptoms induced by NPSs and other club drugs, correlating with the main classes of drugs.MethodsNinety subjects (M/F 59/31) admitted in the Psychiatric Unit of Can Misses Hospital (Ibiza) referring a recent intake of substances were enrolled. The following scales were administered: TLFB (Timeline follow-back); Positive and Negative Symptoms Scale (PANSS); Symptom checklist-90 (SCL-90) ; Young Mania Rating Scale (YMRS) ; Hamilton Depression Scale (HAM-D); Hamilton Anxiety Scale (HAM-A); Modified Overt Aggression Scale (MOAS); Columbia Suicide Severity Rating Scale (C-SSRS).ResultsPolydrug abuse was reported by 67.4% of the sample; the sample was grouped by the main preferred substance in THC-, stimulants-, and depressors-users. The majority of patients reported a previous psychiatric history. Positive symptoms resulted to be higher among THC-users (P < .05). Anxiety evaluated by SCL-90 was prevalent in the group of Depressors-users (P < .05). The scores of MOAS and SCL-90 subscale for hostility/aggression resulted to be significantly (P < .01) greater in the THC-users group.ConclusionsSome specific psychiatric symptoms are characteristic of some classes of substances and may help to identify them when a urine sample is not available. The possibility to develop psychiatric symptoms after a recent drug use is more common in two situations: (1) patients with a previous psychiatric history; (2) subjects with a history of very strong substance use.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Journal articles on the topic 'F substance'

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