Journal articles: 'FA'

1

Kava, R., M. R. C. Greenwood, and P. R. Johnson. "Zucker (fa/fa) Rat." ILAR Journal 32, no. 3 (January 1, 1990): 4–8. http://dx.doi.org/10.1093/ilar.32.3.4.

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2

Plata-Salamán, Carlos R., Elizabeth Peloso, and Evelyn Satinoff. "Cytokine-induced fever in obese (fa/fa) and lean (Fa/Fa) Zucker rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 275, no. 4 (October 1, 1998): R1353—R1357. http://dx.doi.org/10.1152/ajpregu.1998.275.4.r1353.

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In earlier work, we reported that genetically obese ( fa/ fa) Zucker rats exhibited significantly greater anorexia than did lean ( Fa/ Fa) Zucker rats to intracerebroventricular infusion of interleukin (IL)-1β. Here, we investigated the fever response of obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats to intracerebroventricular microinfusion of IL-1β as well as to the following other cytokines: IL-2, IL-6, and tumor necrosis factor-α (TNF-α). Core body temperature was monitored by a radiotelemetry system in freely moving rats. The results show that 1) both IL-1β and IL-6 induce fevers in obese and lean rats; 2) IL-1β induces a significantly higher fever response in obese rats than it does in lean rats; 3) IL-6 induces a significantly higher fever response in lean rats than it does in obese rats; 4) IL-2 induces a moderate fever response in lean but not obese rats; 5) TNF-α induces a similar fever response in obese and lean rats; and 6) the fevers induced by each effective cytokine have different time courses. Thus obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats show differential responsiveness to the intracerebroventricular microinfusion of various classes of cytokines. This suggests that genetic obesity in the fa/fa Zucker rat is associated with differential cytokine action on thermoregulatory mechanisms.

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3

Phillips, Frederick C., and Margot P. Cleary. "Metabolic Measurements among Homozygous (fa/fa) Obese, Heterozygous (Fa/fa) Lean and Homozygous (Fa/Fa) Lean Zucker Rat Pups at 17 Days of Age." Journal of Nutrition 124, no. 8 (August 1, 1994): 1230–37. http://dx.doi.org/10.1093/jn/124.8.1230.

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4

Kamata, Shigeo. "Fa-zang and Fa-men-si." JOURNAL OF INDIAN AND BUDDHIST STUDIES (INDOGAKU BUKKYOGAKU KENKYU) 38, no. 1 (1989): 232–37. http://dx.doi.org/10.4259/ibk.38.232.

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5

Plata-Saláman, Carlos R., Joseph R. Vasselli, and Gayatri Sonti. "Differential Responsiveness of Obese(fa/fa)and Lean(Fa/Fa)Zucker Rats to Cytokine-Induced Anorexia." Obesity Research 5, no. 1 (January 1997): 36–42. http://dx.doi.org/10.1002/j.1550-8528.1997.tb00281.x.

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6

Burgess, Dave. "Master FA Techniques: Curve Tracing in FA." EDFA Technical Articles 20, no. 4 (November 1, 2018): 48. http://dx.doi.org/10.31399/asm.edfa.2018-4.p048.

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7

Koranyi, L., Y. Tanizawa, L. Penicaud, N. Atef, J. Girard, and M. A. Permutt. "Developmental Regulation of Amylin and Insulin-Gene Expression in Lean (Fa/Fa) and obese (fa/fa) Zucker rats." Diabetes 41, no. 6 (June 1, 1992): 685–90. http://dx.doi.org/10.2337/diab.41.6.685.

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8

Ilyin, Sergey E., and Carlos R. Plata-Salamán. "Molecular regulation of the brain interleukin-1β system in obese (fa/fa) and lean (Fa/Fa) Zucker rats." Molecular Brain Research 43, no. 1-2 (December 1996): 209–18. http://dx.doi.org/10.1016/s0169-328x(96)00178-7.

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9

Koranyi, L., Y. Tanizawa, L. Penicaud, N. Atef, J. Girard, and M. A. Permutt. "Developmental regulation of amylin and insulin-gene expression in lean (Fa/Fa) and obese (fa/fa) Zucker rats." Diabetes 41, no. 6 (June 1, 1992): 685–90. http://dx.doi.org/10.2337/diabetes.41.6.685.

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10

De Fanti, Brant A., Robert C. Backus, Jock S. Hamilton, Dorothy W. Gietzen, and Barbara A. Horwitz. "Lean (Fa/Fa) but not obese (fa/fa) Zucker rats release cholecystokinin at PVN after a gavaged meal." American Journal of Physiology-Endocrinology and Metabolism 275, no. 1 (July 1, 1998): E1—E5. http://dx.doi.org/10.1152/ajpendo.1998.275.1.e1.

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Neuropeptides play an important role in the integration of dietary signals. Cholecystokinin (CCK) has been implicated in regulating ingestive behavior, particularly satiety. The primary objective of this study was to examine whether the hyperphagia characteristic of obese ( fa/ fa) rats involves impaired neural CCK secretion. Dynamic release of CCK at the hypothalamic paraventricular nucleus (PVN) of age-matched lean ( Fa/ Fa) and obese Zucker rats was determined using push-pull perfusion. The gavage of a 10.3-kcal (6 ml) liquid diet during lights off was followed by increased CCK release in lean rats (from 13.6 ± 1.1 to 22.1 ± 1.4 fmol in the 1st postprandial period and 18.4 ± 2.5 fmol in the 2nd postprandial period). An identical meal load resulted in no postprandial increase in CCK release in obese rats, despite the fact that high-K+ artificial cerebrospinal fluid evoked CCK outflow in all animals. Intubation of 6 ml of nonnutritive 1% carboxymethylcellulose had no effect. These results are consistent with the suggestion that hypothalamic CCK plays a physiological role in satiety, and they demonstrate that obese Zucker rats have blunted hypothalamic CCK release in response to dietary cues.

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11

De Fanti, Brant A., David A. Gavel, Jock S. Hamilton, and Barbara A. Horwitz. "Extracellular hypothalamic serotonin levels after dorsal raphe nuclei stimulation of lean (Fa/Fa) and obese (fa/fa) Zucker rats." Brain Research 869, no. 1-2 (June 2000): 6–14. http://dx.doi.org/10.1016/s0006-8993(00)02308-8.

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12

Fetissov, Sergueï, Florence Marsais, Stylianos Nicolaïdis, and André Calas. "Expression of tyrosine hydroxylase in magnocellular hypothalamic neurons of obese (fa/fa) and lean heterozygous (Fa/fa) Zucker rats." Molecular Brain Research 50, no. 1-2 (October 1997): 314–18. http://dx.doi.org/10.1016/s0169-328x(97)00240-4.

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13

Routh, Vanessa H., Barbara A. Horwitz, Dorothy W. Gietzen, and Judith S. Stern. "Hypothalamic Monoaminergic Activity in 11-Week-Old Cold-Exposed Female Lean(Fa/Fa)and Obese(fa/fa)Zucker Rats." Obesity Research 2, no. 1 (January 1994): 28–37. http://dx.doi.org/10.1002/j.1550-8528.1994.tb00041.x.

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14

Paoli, Matilde. "Fa caldo!!!" X, 2019/3 (luglio-settembre) 10, no. 3 (July 15, 2011): 53–54. http://dx.doi.org/10.35948/2532-9006/2020.3207.

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Arianna Costantini da Pescara e Andrea Barberi da Roma ci ripropongono una domanda che molti in passato ci hanno già rivolto, ovvero quali siano le espressioni "corrette" in italiano per indicare la sensazione prodotta dall'innalzamento di temperatura. Riportiamo la risposta di Matilde Paoli pubblicata sul n. 35 (ottobre 2007) della Crusca per voi.

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15

Ershov, Yu L. "fA-spaces." Algebra and Logic 25, no. 5 (September 1986): 336–43. http://dx.doi.org/10.1007/bf01982128.

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16

RAYNER, D. VERNON, TERRY ATKINSON, GILLIAN D. DALGLEISH, JACQUELINE S. DUNCAN, NIGEL HOGGARD, and PAUL TRAYHURN. "Hyperleptinaemia precedes hyperinsulinaemia in Zucker (fa/fa) rats." Biochemical Society Transactions 26, no. 2 (May 1, 1998): S98. http://dx.doi.org/10.1042/bst026s098.

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17

Lai, Whalen. "The Defeat of Vijṅāptimatratā in China: Fa-Tsang on Fa-Hsing and Fa-Hsiang." Journal of Chinese Philosophy 13, no. 1 (December 20, 1986): 1–19. http://dx.doi.org/10.1163/15406253-01301001.

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18

LAI, WHALEN. "THE DEFEAT OF VIJÑ'PTIMATRAT' IN CHINA: FA-TSANG ON FA-HSING AND FA-HSIANG." Journal of Chinese Philosophy 13, no. 1 (March 1986): 1–19. http://dx.doi.org/10.1111/j.1540-6253.1986.tb00086.x.

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19

Roane, David S., and Johnny R. Porter. "Nociception and opioid-induced analgesia in lean (Fa/−) and obese (fa/fa) Zucker rats." Physiology & Behavior 38, no. 2 (January 1986): 215–18. http://dx.doi.org/10.1016/0031-9384(86)90156-3.

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20

De Fanti, Brant A., Jock S. Hamilton, and Barbara A. Horwitz. "Meal-induced changes in extracellular 5-HT in medial hypothalamus of lean (Fa/Fa) and obese (fa/fa) Zucker rats." Brain Research 902, no. 2 (June 2001): 164–70. http://dx.doi.org/10.1016/s0006-8993(01)02371-x.

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21

Malnoë, Armand, Isabelle Henzelin, and John C. Stanley. "Phospholipid fatty acid composition and vitamin E levels in the retina of obese (fa/fa) and lean (FA/FA) Zucker rats." Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1212, no. 1 (April 1994): 119–24. http://dx.doi.org/10.1016/0005-2760(94)90196-1.

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22

Adolfo García-Sáinz, J., Rocío Alcántara-Hernández, Martha Robles-Flores, Ma Eugenia Torres-Márquez, Duna Massillon, Borhane Annabi, and Gérald Van de Werve. "Modulation by protein kinase C of the hormonal responsiveness of hepatocytes from lean (Fa/fa?) and obese (fa/fa) Zucker rats." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1135, no. 2 (June 1992): 221–25. http://dx.doi.org/10.1016/0167-4889(92)90140-7.

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23

Picard, Frédéric, Yves Deshaies, Josée Lalonde, Pierre Samson, and Denis Richard. "Topiramate Reduces Energy and Fat Gains in Lean (Fa/?) and Obese (fa/fa) Zucker Rats." Obesity Research 8, no. 9 (December 2000): 656–63. http://dx.doi.org/10.1038/oby.2000.84.

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24

Schwarzer, K., H. Doring, and I. Schmidt. "Different physiological traits underlying increased body fat of fatty (fa/fa) and heterozygous (+/fa) rats." American Journal of Physiology-Endocrinology and Metabolism 272, no. 1 (January 1, 1997): E100—E106. http://dx.doi.org/10.1152/ajpendo.1997.272.1.e100.

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To find out whether the most characteristic physiological traits distinguishing suckling-age fa/fa pups from lean littermates also differ between +/+ and +/fa littermates, we analyzed the body composition and cold defense of 7- and 16-day-old pups and the plasma concentrations of insulin, glucose, triglycerides, and free fatty acids in 16-day-old pups. Zucker rat x Brown Norway hybrid pups were genotyped by using a molecular marker within 0.5 cM of the fa gene. At both ages the +/fa pups had significantly more body fat than their +/+ littermates. At 7 days this difference was as large as that between +/fa and fa/fa pups, but at 16 days it was only one-seventh of the fa/fa vs. +/fa difference. In contrast, there were no heterozygote differences for three parameters that show crucial abnormalities in the fa/fa pups: thermoregulatory thermogenesis and plasma concentrations of insulin and triglycerides. The physiological mechanisms underlying the increased fat content of +/fa pups thus differ from those known to fuel most of the excessive fat deposition of their fa/fa littermates.

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25

Chan, C. B., and K. J. Johnson. "Reduced sensitivity of fa/fa Zucker rats to adrenomedullin." Canadian Journal of Physiology and Pharmacology 75, no. 9 (September 1, 1997): 1138–41. http://dx.doi.org/10.1139/y97-139.

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26

Kowalski, Timothy J., Andrea M. Ster, and Gerard P. Smith. "Ontogeny of hyperphagia in the Zucker ( fa/fa) rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 275, no. 4 (October 1, 1998): R1106—R1109. http://dx.doi.org/10.1152/ajpregu.1998.275.4.r1106.

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The ontogeny of hyperphagic behavior in the Zucker fatty ( fa/ fa) rat was examined. Wild-type, +/ fa, and fa/ fapups aged postnatal day 5( P5), P9, P12, P15, and P18 were evaluated using a test that measured ingestive behavior independent of the dam. The independent ingestive test consisted of giving pups access to a test solution [half-and-half (cream and milk)] on a tissue on the floor of a test chamber for 20 min. The latency to ingest and the intake (weight gain and percent weight gain) were measured and normalized to +/ fa littermates. Pups were tested once to eliminate any effects of test experience. fa/ faPups ingested significantly more than lean pups (+/+ and +/ fa) on P12, P15, and P18, but not on P5 or P9. The latencies of fa/ fapups did not differ significantly from the latencies of +/+ pups except on P18, when the latencies of fa/ fapups were significantly shorter. The latencies of +/ fa pups were significantly longer than the latencies of fa/ faor +/+ pups on P5 and P12. These results demonstrate that hyperphagia in fa/ farats emerges between P9 and P12 under the test conditions used.

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27

Tse, Elizabeth O., Francine M. Gregoire, Brigitte Reusens, Claude Remade, Joseph J. Hoet, Patricia R. Johnson, and Judith S. Stern. "Changes of Islet Size and Islet Size Distribution Resulting from Protein-Malnutrition in Lean(Fa/Fa)and Obese(fa/fa)Zucker Rats." Obesity Research 5, no. 6 (November 1997): 563–71. http://dx.doi.org/10.1002/j.1550-8528.1997.tb00577.x.

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28

Ryuuzaki, Junichi. "Total FA system." JAPAN TAPPI JOURNAL 51, no. 12 (1997): 1898–904. http://dx.doi.org/10.2524/jtappij.51.1898.

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29

Azimuth, Bernard. "Secrets de fa." Sigila N°44, no. 2 (2019): 133. http://dx.doi.org/10.3917/sigila.044.0133.

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30

Lloyd-Hazlett, Jessica, Eleni Maria Honderich, and Karena J. Heyward. "Fa-MI-ly." Family Journal 24, no. 1 (November 25, 2015): 31–37. http://dx.doi.org/10.1177/1066480715615666.

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31

Somogyi, A., F. Bourdain, S. Wuttke, D. Zucman, P. Gepner, and O. Blétry. "Fa-ti-gué." La Revue de Médecine Interne 22 (June 2001): 256–58. http://dx.doi.org/10.1016/s0248-8663(01)83665-1.

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32

Büky, László. "Kaputziner Fa piklivel." Magyar Nyelv 111, no. 2 (2015): 221–23. http://dx.doi.org/10.18349/magyarnyelv.2015.2.221.

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33

Álvarez, Gabriela. "Renombrar la FA." Bitácora Arquitectura, no. 49 (January 24, 2023): 76–79. http://dx.doi.org/10.22201/fa.14058901p.2022.49.84600.

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Bajo el contexto del paro estudiantil por violencia de género, el trabajo de las diversas colectivas feministas de la Facultad de Arquitectura se ha visto reflejado en varios cambios. El presente texto destaca el proceso de renombramientos de los cuatro espacios principales del vestíbulo de la facultad. Este es el primer paso de un proceso de cambio del 75% de los espacios que serán renombrados en un esfuerzo por reconocer y visibilizar a las mujeres. Así pues, se da una breve semblanza de la carrera de estas cuatro mujeres y se señala la importancia de estas acciones.

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34

Hata, Seiji, Kenji Suzuki, Kenzou Takeichi, and Yoshio Taniguchi. "Image processing language for FA cell control, FA-BASIC/V." IEEJ Transactions on Industry Applications 109, no. 3 (1989): 167–74. http://dx.doi.org/10.1541/ieejias.109.167.

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35

Ionescu, E., J. F. Sauter, and B. Jeanrenaud. "Abnormal oral glucose tolerance in genetically obese (fa/fa) rats." American Journal of Physiology-Endocrinology and Metabolism 248, no. 5 (May 1, 1985): E500—E506. http://dx.doi.org/10.1152/ajpendo.1985.248.5.e500.

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The effect of intravenous glucose or tolbutamide administration on plasma glucose and insulin levels was compared with that following spontaneous ingestion of glucose in freely moving 6- to 7-wk- and 13- to 14-wk-old lean and obese (fa/fa) rats. Irrespective of age, the obese rats had a normal blood glucose tolerance when glucose or tolbutamide load was given intravenously, whereas the glucose ingestion [oral glucose tolerance test (OGTT) caused a marked glucose intolerance that became more pronounced with the duration of the syndrome. This suggests that factors other than insulin resistance could play a role in the occurrence of abnormal OGTT in obese rats. When blood insulin levels were expressed as percent change over base line and when compared with age-matched normal rats, the 6- to 7-wk obese rats showed a normal and even higher beta-cell responsiveness to intravenous or oral glucose as well as to tolbutamide. In contrast, the 13- to 14-wk obese rats presented a decreased beta-cell responsiveness to all such stimuli. Thus the beta-cell function of obese rats worsens with time. Inasmuch as 13- to 14-wk-old obese fa/fa rats have insulin resistance, high basal glycemia, and abnormal oral glucose tolerance, they can be viewed as a potential model of type II diabetes.

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36

Smoller, J. W., G. E. Truett, J. Hirsch, and R. L. Leibel. "A molecular genetic method for genotyping fatty (fa/fa) rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 264, no. 1 (January 1, 1993): R8—R11. http://dx.doi.org/10.1152/ajpregu.1993.264.1.r8.

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After three decades of physiological research, the precise nature of the genetic lesion in Zucker fatty (fa/fa) rats remains unknown. Several methods have been used to identify preobese rats to detect the earliest phenotypic effects of the fa mutation. Most of these methods have used phenotypic characteristics that are not reliable until the second week of life, when increased adiposity is already evident. We have used a restriction fragment length polymorphism (RFLP) for a human genomic DNA probe (VC85) that is tightly linked to the fa locus on rat chromosome 5 to genotype the F2 progeny of a Zucker (13M) x Brown Norway (BN) fa/+ F1 intercross. Sixty-four rats, comprising five litters, were killed at 5-6 wk of age. DNA was isolated either from tail at age 4-7 days (36 rats) or from organs at the time of death (28 rats). Adiposity was scored using inguinal fat pad weight as a percentage of body weight. RFLP analysis was > 99% accurate in identifying obese (fa/fa) rats. This molecular genetic method can be used to genotype fatty rats from an appropriate genetic cross at any age, even prenatally. Moreover, this method can distinguish heterozygous from homozygous littermates, enabling an analysis of gene dosage effects.

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37

Bruinstroop, E., J. Eliveld, E. Foppen, S. Busker, M. T. Ackermans, E. Fliers, and A. Kalsbeek. "Hepatic denervation and dyslipidemia in obese Zucker (fa/fa) rats." International Journal of Obesity 39, no. 11 (July 2, 2015): 1655–58. http://dx.doi.org/10.1038/ijo.2015.122.

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38

Kowalski, Timothy J., Thomas A. Houpt, Jeongwon Jahng, Nori Okada, Shun-Mei Liu, Streamson C. Chua, and Gerard P. Smith. "Neuropeptide Y Overexpression in the Preweanling Zucker (fa/fa) Rat." Physiology & Behavior 67, no. 4 (October 1999): 521–25. http://dx.doi.org/10.1016/s0031-9384(99)00095-5.

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39

Chan, Catherine B., Glenda M. Wright, Dorota W. Wadowska, Ruth M. MacPhail, William P. Ireland, and Kenneth W. Sulston. "Ultrastructural and secretory heterogeneity of fa/fa (Zucker) rat islets." Molecular and Cellular Endocrinology 136, no. 2 (January 1998): 119–29. http://dx.doi.org/10.1016/s0303-7207(97)00220-7.

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40

KANDA, Yuichi. "FA Control and Network Technology. Trend of FA Control Network." Journal of the Japan Society for Precision Engineering 65, no. 9 (1999): 1245–48. http://dx.doi.org/10.2493/jjspe.65.1245.

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41

Apweiler, R., and P. Freund. "Development of Glucose Intolerance in Obese (fa/fa) Zucker Rats." Hormone and Metabolic Research 25, no. 10 (October 1993): 521–24. http://dx.doi.org/10.1055/s-2007-1002165.

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42

SVEC, FRANK, JUDE ABADIE, ELIZABETH S. BROWNE, and JOHNNY R. PORTER. "Dehydroepiandrosterone and Macronutrient Selection by Obese Zucker Rats (fa/fa)." Appetite 25, no. 2 (October 1995): 143–54. http://dx.doi.org/10.1006/appe.1995.0051.

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43

Schwartz, Michael W., Jonathan L. Marks, Alfred J. Sipolst, Denis G. Basking, Stephen C. Woods, Steven E. Kahn, and Daniel Porte. "CENTRAL INSULIN ADMINISTRATION REDUCES NEUROPEPTIDE Y mRNA EXPRESSION IN THE ARCUATE NUCLEUS OF FOOD-DEPRIVED LEAN (Fa/Fa) BUT NOT OBESE (fa/fa) ZUCKER RATS." Endocrinology 128, no. 5 (May 1991): 2645–47. http://dx.doi.org/10.1210/endo-128-5-2645.

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44

Sista, Akhilesh K., Mary K. O'Connell, Tomoya Hinohara, Santosh S. Oommen, Brett E. Fenster, Alexander J. Glassford, Eric A. Schwartz, Charles A. Taylor, Gerald M. Reaven, and Philip S. Tsao. "Increased aortic stiffness in the insulin-resistant Zucker fa/fa rat." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 2 (August 2005): H845—H851. http://dx.doi.org/10.1152/ajpheart.00134.2005.

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Accumulating clinical evidence indicates increased aortic stiffness, an independent risk factor for cardiovascular and all-cause mortality, in type 2 diabetic and glucose-intolerant individuals. The present study sought to determine whether increased mechanical stiffness, an altered extracellular matrix, and a profibrotic gene expression profile could be observed in the aorta of the insulin-resistant Zucker fa/fa rat. Mechanical testing of Zucker fa/fa aortas showed increased vascular stiffness in longitudinal and circumferential directions compared with Zucker lean controls. Unequal elevations in developed strain favoring the longitudinal direction resulted in a loss of anisotropy. Real-time quantitative PCR and immunohistochemistry revealed increased expression of fibronectin and collagen IVα3 in the Zucker fa/fa aorta. In addition, expression of transforming growth factor-β and several Smad proteins was increased in vessels from insulin-resistant animals. In rat vascular smooth muscle cells, 12–18 h of exposure to insulin (100 nmol/l) enhanced transforming growth factor-β1 mRNA expression, implicating a role for hyperinsulinemia in vascular stiffness. Thus there is mechanical, structural, and molecular evidence of arteriosclerosis in the Zucker fa/fa rat at the glucose-intolerant, hyperinsulinemic stage.

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45

Doi, Takahiro, Keiji Kajimura, and Shuzo Taguchi. "Survey of Formaldehyde (FA) Concentration in Cosmetics Containing FA-donor Preservatives." JOURNAL OF HEALTH SCIENCE 56, no. 1 (2010): 116–22. http://dx.doi.org/10.1248/jhs.56.116.

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46

Wolf, Bryan W., Phillip M. Humphrey, Craig W. Hadley, Kati S. Maharry, Keith A. Garleb, and Jeffrey L. Firkins. "Supplemental Fructose Attenuates Postprandial Glycemia in Zucker Fatty fa/fa Rats." Journal of Nutrition 132, no. 6 (June 1, 2002): 1219–23. http://dx.doi.org/10.1093/jn/132.6.1219.

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47

Metz, Lore, Marianne Vermaelen, Karen Lambert, Christophe Broca, Pascal Sirvent, Eric Raynaud, and Jacques Mercier. "Endurance training increases lactate transport in male Zucker fa/fa rats." Biochemical and Biophysical Research Communications 331, no. 4 (June 2005): 1338–45. http://dx.doi.org/10.1016/j.bbrc.2005.04.054.

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48

Rasmussen, Erin B., William Reilly, and Conrad Hillman. "Demand for sucrose in the genetically obese Zucker (fa/fa) rat." Behavioural Processes 85, no. 2 (October 2010): 191–97. http://dx.doi.org/10.1016/j.beproc.2010.07.008.

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49

Rodríguez, Amaia, Sara Becerril, Víctor Valentí, Beatriz Ramírez, Marina Martín, Leire Méndez-Giménez, Andoni Lancha, et al. "Sleeve Gastrectomy Reduces Blood Pressure in Obese (fa/fa) Zucker Rats." Obesity Surgery 22, no. 2 (November 20, 2011): 309–15. http://dx.doi.org/10.1007/s11695-011-0562-3.

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50

Chan, C. B. "Glucokinase activity in isolated islets from obese fa/fa Zucker rats." Biochemical Journal 295, no. 3 (November 1, 1993): 673–77. http://dx.doi.org/10.1042/bj2950673.

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Glucokinase (EC 2.7.1.2) activity of B-cells was measured in extracted pancreatic islets isolated from lean and obese fa/fa Zucker rats and maintained in primary culture overnight. Formation of [14C]glucose phosphoric esters from D-[U-14C]glucose was measured in the presence of unlabelled glucose from 0.05 to 0.50 mM for hexokinase (EC 2.7.1.1) activity, and 8.0-16.0 mM unlabelled glucose for glucokinase activity. Eadie-Hofstee analysis revealed that hexokinase kinetic parameters (Vmax and Km) for [14C]glucose phosphoric ester formation were similar in lean- and fa/fa-rat islets. For glucokinase, there was no difference in Vmax. between phenotypes. A non-significant tendency to increased sensitivity to glucose was noted in the fa/fa-rat islets (P = 0.13). In lean-rat islets, the glucokinase inhibitor mannoheptulose (3 mM) decreased Vmax. by 80% and increased the apparent Km from 3.3 +/- 0.7 mM to 12.2 +/- 2.0 mM (P < 0.05). There was no difference in Km or Vmax. in mannoheptulose-treated versus control islets from fa/fa rats. This lack of effect was consistent with reported effects of mannoheptulose on insulin secretion from fa/fa-rat islets [Chan, MacPhail and Mitton (1993) Can. J. Physiol. Pharmacol. 71, 34-39]. The data from glucose and mannoheptulose experiments support the hypothesis that glucokinase function is altered in fa/fa Zucker rats and may contribute to fasting hyperinsulinaemia in vivo in these animals.

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Journal articles on the topic 'FA'

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