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Journal articles on the topic 'Facial Pain; Trigeminal Neuralgia; Laser Therapy'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Guilherme, Alves Aguiar, Luiz Barbosa Pinheiro Antônio, and Cristina Teixeira Cangussu Maira. "Use Of Laser Phototherapy In The Treatment Of Trigeminal Neuralgia." INTERNATIONAL JOURNAL OF HEALTH & MEDICAL RESEARCH 03, no. 03 (2024): 121–26. https://doi.org/10.5281/zenodo.10819867.

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Responsible for  the sensory stimuli of the viscerocranium, the 5th pair of cranial nerves, called the trigeminal nerve due to its 3 branches, is a mixed-function nerve. The diagnosis of Trigeminal Neuralgia is directly related to the symptoms reported by the patient during the anamnesis. The right treatment depends on the correct diagnosis. The exact etiology of TN is still unknown. It affects around 4 to 13 individuals per 100,000 and although it seems to be a neuropathy with a low incidence, it is the most common among facial pain syndromes. A retrospective cross-sectional observationa

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Saraswathi Gopal.K, Mahesh Kumar.P, and Harini. B. K. "Low level laser therapy in the management of trigeminal neuralgia: A rare case report." International Journal of Science and Research Archive 12, no. 1 (2024): 2026–30. http://dx.doi.org/10.30574/ijsra.2024.12.1.0938.

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Trigeminal neuralgia (TN) is characterized by sudden, severe, brief, and stabbing recurrent episodes of facial pain in one or more branches of the trigeminal nerve. Pain attacks can occur spontaneously or can be triggered by non-noxious stimuli, such as talking, eating, washing the face, brushing teeth, shaving, a light touch or even a cool breeze. In addition to pain attacks, a proportion of the patients also experience persistent background pain, which along with autonomic signs and prolonged disease duration, represent predictors of worse treatment outcomes. Here, we present a classical cas

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Martinez, Diego M., Billy K. Huh, and Saba Javed. "Case report: use of high-intensity laser therapy for treatment of trigeminal neuralgia." Pain Management 13, no. 12 (2023): 709–16. http://dx.doi.org/10.2217/pmt-2023-0112.

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Trigeminal neuralgia represents a form of chronic facial pain that is characterized by its incapacitating nature. The current therapeutic approaches encompass pharmacological agents with carbamazepine or non-pharmacologic options including utilization of percutaneous rhizotomy, Gamma knife radiosurgery or microvascular decompression may be indicated in certain cases. While the interventions may be effective, medications have negative side effects and procedures are invasive which can pose challenges for patients with various comorbidities. High-intensity laser therapy (HILT) has demonstrated s

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4

Eckerdal, Arne, and Lehmann Bastian. "CAN LOW REACTIVE-LEVEL LASER THERAPY BE USED IN THE TREATMENT OF NEUROGENIC FACIAL PAIN? A DOUBLE-BLIND, PLACEBO CONTROLLED INVESTIGATION OF PATIENTS WITH TRIGEMINAL NEURALGIA." LASER THERAPY 8, no. 4 (1996): 247–51. http://dx.doi.org/10.5978/islsm.8.247.

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Walker, J. B., L. K. Akhanjee, M. M. Cooney, J. Goldstein, S. Tamzyoshi, and F. Segal-Gidan. "Laser Therapy for Pain of Trigeminal Neuralgia." Clinical Journal of Pain 3, no. 4 (1987): 183–88. http://dx.doi.org/10.1097/00002508-198712000-00001.

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Mitra, Sukanya, Prateek Upadhyay, Jasveer Singh, and Prashant Ahlawat. "Noninvasive pulsed radiofrequency for trigeminal neuralgia: Off the beaten path – Case series." Saudi Journal of Anaesthesia 18, no. 4 (2024): 569–72. http://dx.doi.org/10.4103/sja.sja_208_24.

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Trigeminal neuralgia (TN) is a debilitating condition characterized by excruciating facial pain resulting from dysfunction in the trigeminal nerve. Treatment options are limited. Noninvasive pulsed radiofrequency (PRF) therapy is an emerging promising approach to managing TN. This therapy provides pain control without tissue damage or unpleasant side effects compared to invasive procedures. Here, we present five cases of trigeminal neuralgia successfully managed with noninvasive PRF therapy. Our case series contributes to the existing literature and supports the potential efficacy of noninvasi

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Mario Francesco, Fraioli, Lisciani Damiano, Pagano Andrea, and Fraioli Chiara. "Bilateral Trigeminal Neuralgia Refractory to Medical Therapy: Importance of A Multi-Therapeutic Approach." Archives of Case Reports 9, no. 1 (2025): 016–18. https://doi.org/10.29328/journal.acr.1001123.

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Bilateral trigeminal neuralgia refractory to medical therapy is a rare occurrence and it is mandatory to choose therapeutic procedures minimizing possible bilateral sensitive deficit due to the employment of bilateral mininvasive ablative techniques. A patient affected by bilateral trigeminal neuralgia refractory to medical therapy secondary to multiple sclerosis is presented. Multiple therapeutic tools were employed in this challenging pathology. The second and third left trigeminal divisions were involved by the neuralgia, while the third division was involved in the right facial side. Contr

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Kolakowski, Lukasz, Heiko Pohl, Lennart Stieglitz, et al. "Interdisciplinary strategies for diagnosis and treatment of trigeminal neuralgia." Swiss Medical Weekly 154, no. 7 (2024): 3460. http://dx.doi.org/10.57187/s.3460.

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Temporary, sudden, shooting and recurrent unilateral facial pain in the supply area of one or more trigeminal nerve branches characterises trigeminal neuralgia. Innocuous stimuli trigger the pain, e.g. chewing, speaking or brushing teeth. In some patients, paroxysms superimpose on continuous pain. In aetiological terms, idiopathic, classic (due to neurovascular compression) and secondary trigeminal neuralgia (e.g. due to multiple sclerosis, brainstem ischaemia and space-occupying lesions) are defined. Many drugs may be efficacious, with carbamazepine being first-choice therapy. However, non-ph

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Vásquez, Bélgica. "Trigeminal Neuralgy." International Journal of Medical and Surgical Sciences 1, no. 4 (2018): 353–58. http://dx.doi.org/10.32457/ijmss.2014.044.

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The objective of this review was to present information on the main causes, possible treatments and morpho-quantitative aspects of trigeminal neuralgia. Trigeminal neuralgia is a condition characterized by intense facial pain, severe throbbing or stabbing; it is usually unilateral and recurrent and is located in the facial area innervated by the trigeminal nerve. The causes of this disease are varied and include neurovascular compression stresses. Medical treatment of choice is carbamazepine, reserving surgical treatment for cases resistant to medical therapy or cases when side effects of drug

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10

Rulewska, Natalia Maria, Filip Grabowski, Dagmara Neska, et al. "Radiofrequency thermocoagulation of Gasserian ganglion in trigeminal neuralgia." Journal of Education, Health and Sport 77 (January 9, 2025): 56674. https://doi.org/10.12775/jehs.2025.77.56674.

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Introduction: Trigeminal neuralgia (TN) is a form of neuropathic pain that targets the fifth cranial nerve, leading to intense facial pain that can significantly impact one’s quality of life. This condition typically manifests as recurring episodes of sharp, unilateral pain along one or more branches of the trigeminal nerve.The exact mechanism of trigeminal neuralgia remains largely unknown. Most pain attacks are triggered by certain stimuli in the areas served by the trigeminal nerve. One possible treatment approach for trigeminal neuralgia is radiofrequency thermocoagulation. Aim: The aim of

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Claypool, Amy, and Christopher K. Wong. "Role of Physical Therapy in Trigeminal Neuralgia: A Case With 4-Year Follow-up." JOSPT Cases 3, no. 2 (2023): 119–26. http://dx.doi.org/10.2519/josptcases.2023.11446.

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BACKGROUND: Trigeminal neuralgia presents with acute stabbing unilateral facial pain along the nerve distribution precipitated by innocuous sensory stimuli. Trigeminal neuralgia can be unrelenting and can lead to severe physical and emotional consequences. Medical and surgical intervention often has adverse effects, and reports of physical therapy treatment are uncommon. CASE PRESENTATION: The patient in this case presented for physical therapy with a history of head/neck surgery, migraines and headaches, joint pain, and depression, with severe sharp shock-like pain aggravated by innocuous ora

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Kendall, Mark C. "Ultrasound-Guided Pulsed Radiofrequency Application via the Pterygopalatine Fossa: A Practical Approach to Treat Refractory Trigeminal Neuralgia." May 2015 3;18, no. 3;5 (2015): E411—E415. http://dx.doi.org/10.36076/ppj.2015/18/e411.

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Although pharmacological therapy is the primary treatment modality for trigeminal neuralgia associated pain, ineffective analgesia and dose limiting side effects often prompt patients to seek alternative pharmacological solutions such as interventional nerve blockade. Blockade of the Gasserian ganglion or its branches is an effective analgesic procedure for trigeminal neuralgia, traditionally performed using fluoroscopy or CT imaging. Ultrasonography allows point of care and real time visualization of needle placement within the surrounding anatomical structures. The use of ultrasonography wit

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Klein, Johann, Sahr Sandi-Gahun, Gabriele Schackert, and Tareq A. Juratli. "Peripheral nerve field stimulation for trigeminal neuralgia, trigeminal neuropathic pain, and persistent idiopathic facial pain." Cephalalgia 36, no. 5 (2015): 445–53. http://dx.doi.org/10.1177/0333102415597526.

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Objective Peripheral nerve field stimulation (PNFS) is a promising modality for treatment of intractable facial pain. However, evidence is sparse. We are therefore presenting our experience with this technique in a small patient cohort. Methods Records of 10 patients (five men, five women) with intractable facial pain who underwent implantation of one or several subcutaneous electrodes for trigeminal nerve field stimulation were retrospectively analyzed. Patients’ data, including pain location, etiology, duration, previous treatments, long-term effects and complications, were evaluated. Result

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Park, Chang Kyu, Seung Hoon Lim, and Bong Jin Park. "Diagnosis and treatment of trigeminal neuralgia." Journal of the Korean Medical Association 66, no. 1 (2023): 11–18. http://dx.doi.org/10.5124/jkma.2023.66.1.11.

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Background: Trigeminal neuralgia is a sudden and painful facial condition that is triggered by activities of daily living. The pain is debilitating and patients are often unable to perform routine daily tasks such as washing their face, shaving, and brushing their teeth, which in turn has an impact on their social life and mental well-being as they are often anxious and fearful of not knowing when the pain may occur.Current Concepts: Treatment for trigeminal neuralgia involves local nerve destruction surgeries, including neuroblocking, percutaneous ethanol injection therapy, percutaneous radio

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15

Yang, Andrew I., Brendan J. McShane, Frederick L. Hitti, Sukhmeet K. Sandhu, H. Isaac Chen, and John Y. K. Lee. "Patterns of opioid use in patients with trigeminal neuralgia undergoing neurosurgery." Journal of Neurosurgery 131, no. 6 (2019): 1805–11. http://dx.doi.org/10.3171/2018.8.jns1893.

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OBJECTIVEFirst-line treatment for trigeminal neuralgia (TN) is pharmacological management using antiepileptic drugs (AEDs), e.g., carbamazepine (CBZ) and oxcarbazepine (OCBZ). Surgical intervention has been shown to be an effective and durable treatment for TN that is refractory to medical therapy. Despite the lack of evidence for efficacy in patients with TN, the authors hypothesized that patients with neuropathic facial pain are prescribed opioids at high rates, and that neurosurgical intervention may lead to a reduction in opioid use.METHODSThis is a retrospective study of patients with fac

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Sharma, A., A. Kumar, V. Kumar, M. Goel, A. Hooda, and A. Dahiya. "Trigeminal Neuralgia: The New Surgical Treatment Modalities." Journal of Oral Health and Community Dentistry 9, no. 1 (2015): 40–43. http://dx.doi.org/10.5005/johcd-9-1-40.

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ABSTRACT Trigeminal Neuralgia is a painful condition of the oro-facial structures. The diagnostic criteria are based upon the patient's history, examination and clinical evaluation. In the course of the disease patients experience dull, aching, throbbing or burning, constant pain in the same distribution as the paroxysms. A long interval between the attacks is often described as a period of increasing paresthesias in the nerve distribution. The trigger stimulus, applied to the “trigger zone”, often arouses intense pain in divisions beyond the one stimulated. Treatment involves the medicinal as

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McNatt, Sean A., Cheng Yu, Steven L. Giannotta, et al. "Gamma Knife Radiosurgery for Trigeminal Neuralgia." Neurosurgery 56, no. 6 (2005): 1295–303. http://dx.doi.org/10.1227/01.neu.0000160073.02800.c7.

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Abstract OBJECTIVE: The purpose of this study was to assess outcomes in patients treated with gamma knife radiosurgery for trigeminal neuralgia. METHODS: From 1997 to 2003, a total of 49 patients with trigeminal neuralgia underwent gamma knife radiosurgery. The trigeminal root entry zone immediately adjacent to the pons was targeted by use of a 4-mm collimator to deliver 40 Gy to the 50% isodose line (maximum dose, 80 Gy). Special care was taken to limit radiation dose to the adjacent pons to 12 Gy. Of the 49 study patients, all had undergone previous medical therapy, 8 (16%) had undergone mic

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Yanushevich, O. O., and S. A. Rabinovich. "Facial neurology: paroxysmal neuralgia (a contribution by Professor Karlov)." Epilepsy and paroxysmal conditions 13, no. 1S (2021): 17–20. http://dx.doi.org/10.17749/2077-8333/epi.par.con.2021.073.

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This report has been dedicated to study facial neurology, which were profoundly impacted by Professor V.A. Karlov. Dento-neurology as a separate medical field assessing diagnostics and treatment of face and neck pain syndrome, therapy of cerebral-cranial nerves and defuncted maxillotemporal joint. Importance of visualization techniques used upon therapy of trigeminal neuralgy was emphasized.

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Przeklasa-Muszyńska, Anna, Bartłomiej Pancerz, Magdalena Kocot-Kępska, and Jan Dobrogowski. "The use of Pulsed Radiofrequency in the treatment oftrigeminal neuralgia and painful trigeminal neuropathy –two clinical cases." BÓL 24, no. 3 (2023): 35–41. http://dx.doi.org/10.5604/01.3001.0053.9495.

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Trigeminal neuralgia, one of the pain conditions with severe pain, can be effectively treated with pharmacotherapyand invasive methods of pain treatment (at the level of the peripheral nerve, Gasser's ganglion, or nerve root). Painfultrigeminal neuropathy is defined as facial pain in one or more branches of the trigeminal nerve caused by otherconditions or damage to the nerve. This condition can be effectively treated with individual pharmacotherapy andnon-pharmacological methods, and in some cases, invasive methods. In both diseases, many treatment methodscan be proposed, including the minima

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Smolanka, V. V. "Clinical characteristics of pain in patients with trigeminal neuralgia: data from a neurosurgical clinic." Ukrainian Interventional Neuroradiology and Surgery 43, no. 1 (2023): 36–41. http://dx.doi.org/10.26683/2786-4855-2023-1(43)-36-41.

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Among the pain syndromes caused by damage to cranial nerves, trigeminal nerve pathology occupies the main place. Trigeminal neuralgia is an exhausting condition characterized by acute shooting recurrent pain in the face. However, according to modern classification of facial pain types, there is also a distinction made for the second type of neuralgia, in which the mentioned pain alternates with dull, burning pain in the area of trigeminal nerve innervation. Numerous clinical and diagnostic criteria which can influence the results of surgical treatment of trigeminal neuralgia are being actively

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Johnson, Mark D., and Kim J. Burchiel. "Peripheral Stimulation for Treatment of Trigeminal Postherpetic Neuralgia and Trigeminal Posttraumatic Neuropathic Pain: A Pilot Study." Neurosurgery 55, no. 1 (2004): 135–42. http://dx.doi.org/10.1227/01.neu.0000126874.08468.89.

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Abstract OBJECTIVE: Trigeminal neuropathic pain (TNP) after facial trauma or herpes zoster infection is often refractory to treatment. Peripheral nerve stimulation has been used to treat occipital neuralgia; however, efficacy in controlling facial TNP or postherpetic neuralgia is unknown. A retrospective case series of patients who underwent subcutaneous placement of stimulating electrodes for treatment of V1 or V2 TNP secondary to herpetic infection or facial trauma is presented. METHODS: Ten patients received implanted subcutaneous pulse generators and quadripolar electrodes for peripheral s

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Vivid Prety Anggraini and Fakhrur Razi. "Unveiling the Potential of Perineural Injection Therapy in Trigeminal Neuralgia Management." Surabaya Physical Medicine and Rehabilitation Journal 7, no. 1 (2025): 90–105. https://doi.org/10.20473/spmrj.v7i1.56458.

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Trigeminal neuralgia is characterized by severe pain that is restricted to the trigeminal nerve and frequently causes abrupt, severe bouts in the face. About 80% of cases of classical trigeminal neuralgia are classed as idiopathic. With the use of the Numeric Rating Scale (NRS) and the SF-36 questionnaire, this case study aims to determine how perineural injection therapy (PIT) affects pain relief in early trigeminal neuralgia cases and how it can affect patient function. The patient presented with a history of 8 years persistent facial pain, localized to the right side of the face. Described

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Kendall, Mark C. "Ultrasound-Guided Trigeminal Nerve Block via the Pterygopalatine Fossa: An Effective Treatment for Trigeminal Neuralgia and Atypical Facial Pain." Pain Physician 5;16, no. 5;9 (2013): E537—E545. http://dx.doi.org/10.36076/ppj.2013/16/e537.

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Background: Patients presenting with facial pain often have ineffective pain relief with medical therapy. Cases refractory to medical management are frequently treated with surgical or minimally invasive procedures with variable success rates. We report on the use of ultrasound-guided trigeminal nerve block via the pterygopalatine fossa in patients following refractory medical and surgical treatment. Objective: To present the immediate and long-term efficacy of ultrasound-guided injections of local anesthetic and steroids in the pterygopalatine fossa in patients with unilateral facial pain tha

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Fedirko, V., A. Dubrovka, and B. Luzan. "Complications of invasive surgery for trigeminal neuralgia." Pain medicine 9, no. 3-4 (2025): 18–26. https://doi.org/10.31636/pmjua.v9i3-4.2.

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Trigeminal neuralgia (TN) is a severe chronic condition characterized by acute pain that can lead to disability. For patients unresponsive to pharmacological therapy, surgical methods such as microvascular decompression (MVD), radiofrequency thermocoagulation, balloon compression, glycerol rhizotomy, or cryoablation are primary treatment options. However, each of these procedures carries specific risks of complications, including nerve damage, infections, hemorrhagic complications, pain recurrences, and method-specific side effects. This article presents the results of a retrospective analysis

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Latysheva, N. V., E. G. Filatova, Al B. Danilov, R. R. Parsamyan, and E. A. Salina. "Temporomandibular disorder and other causes of orofacial pain: first international classification and new treatment perspectives." Medical alphabet 4, no. 35 (2020): 40–46. http://dx.doi.org/10.33667/2078-5631-2019-4-35(410)-40-46.

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The diagnosis and treatment of orofacial pain is in many cases a complex task due to difficulties in history taking, multi‑faceted pathology, psychiatric comorbidities and psychosocial factors involved in such pain. Neurologists tend to overdiagnose trigeminal neuralgia. However, other types of neuropathiс orofacial pain are also common. Moreover, neurologists are often unfamiliar with the temporomandibular disorder and tend to neglect this extremely prevalent cause of orofacial pain. Correct understanding of the causes of orofacial pain is vital not only for treatment selection, but also to m

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Karagözoğlu, İrem, Nermin Demirkol, Özge Parlar Öz, Gökçe Keçeci, Beste Çetin, and Mutlu Özcan. "Clinical Efficacy of Two Different Low-Level Laser Therapies for the Treatment of Trigeminal Neuralgia: A Randomized, Placebo-Controlled Trial." Journal of Clinical Medicine 13, no. 22 (2024): 6890. http://dx.doi.org/10.3390/jcm13226890.

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Background: Trigeminal neuralgia (TN) is a disease that causes severe pain that can seriously affect the quality of life. This study aimed to compare the effectiveness of two different low-level laser therapies (LLLT) as alternatives to medical treatment to reduce pain and improve the quality of life in patients with TN. Methods: A total of 45 patients were randomly divided into 3 groups. In the first group, a new-generation diode laser (GRR laser) was applied at predetermined points in the trigeminal nerve line. In the second group, a low-level neodymium-doped yttrium aluminum garnet (Nd:YAG)

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Schmid, G. J., R. M. M. Seibel, D. H. W. Grönemeyer, and P. Van Leeuwen. "Micro-invasive CT guided therapy for trigeminal neuralgia and atypical facial pain." Minimally Invasive Therapy 3, no. 6 (1994): 323–29. http://dx.doi.org/10.3109/13645709409153031.

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Tereshko, Yan, Simone Dal Bello, Christian Lettieri, et al. "Botulinum Toxin Type A for Trigeminal Neuralgia: A Comprehensive Literature Review." Toxins 16, no. 11 (2024): 500. http://dx.doi.org/10.3390/toxins16110500.

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Trigeminal neuralgia is a neuropathic pain syndrome responsive to botulinum toxin type A therapy. This review had the goal of analyzing the different studies published from 2002 to January 2024 to better define the techniques and the types of botulinum toxin type A used, the doses, the injection routes, and the different populations of trigeminal neuralgia patients treated. We considered only articles in which the therapy was administered to humans to treat trigeminal neuralgia. Case reports, case series, open-label, retrospective, and RCT studies were considered. The research was conducted on

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Kanaev, R., A. Kydyrbaeva, and Ch Niyazbekov. "Comprehensive Treatment of Patients With Classical Trigeminal Neuralgia." Bulletin of Science and Practice, no. 9 (September 15, 2023): 151–58. http://dx.doi.org/10.33619/2414-2948/94/18.

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Trigeminal neuralgia is a chronic disease characterized by short paroxysms of intense excruciating shooting pains in the innervation zone of one or more branches of the trigeminal nerve. Trigeminal neuralgia is a common disease, it occurs with a frequency of 4-5 to 30-50 cases per 100,000 population — according to reports, about 15,000 new patients are diagnosed in the United States annually. The practical social severity of trigeminal neuralgia is high — the severity of pain attacks leads to a significant disruption of the flow of the normal rhythm of life of patients. Among the conservative

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Saraswathi Gopal K, Poongodi V, and Surekha S. "A diagnostic dilemma: Acute mastoiditis presenting as facial pain and trismus: A case study." World Journal of Advanced Research and Reviews 25, no. 3 (2025): 697–701. https://doi.org/10.30574/wjarr.2025.25.3.0721.

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This case highlights the diagnostic challenge of patient presented with acute mastoiditis, pain in the distribution of trigeminal nerve and restricted mouth opening.A 23 year old female initially diagnosed as myofascial pain dysfunction syndrome and given medications, no symptom free period achieved after medications, later suspection of trigeminal neuralgia showed no improvement in conventional treatments.MRI revealed an finding of acute mastoiditis despite the absent of symptoms like ear pain, patient’s condition improved after prompt antibiotic therapy and surgical intervention.This case hi

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Bharti, Neerja. "Radiofrequency Thermoablation of the Gasserian Ganglion Versus the Peripheral Branches of the Trigeminal Nerve for Treatment of Trigeminal Neuralgia: A Randomized, Control Trial." Pain Physician 2, no. 22.2 (2019): 147–54. http://dx.doi.org/10.36076/ppj/2019.22.147.

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Background: Trigeminal neuralgia is the most painful condition of facial pain leading to impairment of routine activities. Although radiofrequency thermoablation (RFT) of the Gasserian ganglion is widely used for the treatment of idiopathic trigeminal neuralgia in patients having ineffective pain relief with medical therapy, the incidence of complications like hypoesthesia, neuroparalytic keratitis, and masticatory muscles weakness is high. Recent case reports have shown the effectiveness of RFT of the peripheral branches of the trigeminal nerve for relief of refractory chronic facial pain con

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Vinokurov, Aleksey G., Aleksander A. Kalinkin, Andrey А. Bocharov, and Olga N. Kalinkina. "Five-year result of Microvascular decompression using video endoscopy in the treatment of classic trigeminal neuralgia with paroxysmal pain syndrome." Journal of Clinical Practice 11, no. 4 (2020): 5–13. http://dx.doi.org/10.17816/clinpract50130.

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Background. The incidence of trigeminal neuralgia (TN) is 15 per 100,000 people per year. The effectiveness of the existing conservative methods of therapy does not exceed 50%. At the same time, the use of carbamazepine doubles the frequency of depressive conditions, and by 40% increases the incidence of suicidal thoughts. Microvascular decompression (MVD) of the trigeminal root is a"gold standard" treatment for patients with facial pain, however, due to the lack of awareness of the disease, not all the patients receive the adequate therapy timely. Aims: to evaluate the long-term results of vi

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Perszke, Michał, Dominika Egierska, and Patrycja Martynowicz. "Trigeminal Neuralgia - where are we today?" Journal of Education, Health and Sport 12, no. 9 (2022): 113–27. http://dx.doi.org/10.12775/jehs.2022.12.09.015.

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Introduction: Trigeminal neuralgia (TN) is one of the most crippling facial pain syndromes, which has a significant impact on quality of life. This chronic disorder presents as brief shock-like paroxysmal severe, stabbing pain with rapid onset in the distribution of trigeminal nerve (CNV). The aim of this article was to review the recent literature about the epidemiology, pathogenesis, diagnosis, treatment methods and the important advances in all these fields.Etiology and pathomechanism: The best known and tested theory on the genesis of the trigeminal neuralgia seems to be a nerve compressio

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Longhi, Michele, Paolo Rizzo, Antonio Nicolato, Roberto Foroni, Mario Reggio, and Massimo Gerosa. "GAMMA KNIFE RADIOSURGERY FOR TRIGEMINAL NEURALGIA." Neurosurgery 61, no. 6 (2007): 1254–61. http://dx.doi.org/10.1227/01.neu.0000306104.68635.d4.

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Abstract OBJECTIVE Gamma knife radiosurgery (GKR) is an increasingly used, minimally invasive treatment option for patients with trigeminal neuralgia (TN) refractory to medical therapy. This retrospective study evaluates the long-term results and side effects of GKR in the treatment of TN focusing on potentially predictive factors. METHODS One hundred sixty patients with TN were included in this study (minimum follow-up, &gt;6 mo; mean, 37.4 mo; range, 6–144 mo). In 92 patients, GKR represented the first nonmedical option (“primary GKR”). In 68 patients, invasive treatments had been previo

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Liu, Yao, and Eiji Tanaka. "Pathogenesis, Diagnosis, and Management of Trigeminal Neuralgia: A Narrative Review." Journal of Clinical Medicine 14, no. 2 (2025): 528. https://doi.org/10.3390/jcm14020528.

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Trigeminal neuralgia (TN) is an excruciating neurological disorder characterized by intense, stimulus-induced, and transient facial stabbing pain. The classification of TN has changed as a result of new discoveries in the last decade regarding its symptomatology, pathogenesis, and management. Because different types of facial pain have different clinical therapy and neuroimaging interpretations, a precise diagnosis is essential. Diagnosis should include magnetic resonance imaging with specific sequences to rule out secondary causes and to identify possible neurovascular contact. The purpose of

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Papanastassiou, Alexander M., Richard B. Schwartz, and Robert M. Friedlander. "CHIARI I MALFORMATION AS A CAUSE OF TRIGEMINAL NEURALGIA." Neurosurgery 63, no. 3 (2008): E614—E615. http://dx.doi.org/10.1227/01.neu.0000324726.93370.5c.

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ABSTRACT OBJECTIVE Trigeminal neuralgia (TN) is usually associated with vascular compression of the trigeminal nerve, but some cases are associated with central lesions such as tumors, aneurysms, or arteriovenous malformations. In this article, we report the 19th case of TN associated with Chiari I malformation and review clinical outcomes and pathophysiology. CLINICAL PRESENTATION A 63-year-old right-handed man initially presented in 1993 with left-sided lancinating facial pain in the V2 distribution of the trigeminal nerve; the pain was triggered by certain movements, tactile stimulation, or

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Wilkinson, Harold A. "Trigeminal nerve peripheral branch phenol/glycerol injections for tic douloureux." Journal of Neurosurgery 90, no. 5 (1999): 828–32. http://dx.doi.org/10.3171/jns.1999.90.5.0828.

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Object. Trigeminal neuralgia or tic douloureux is a disease affecting older individuals, and thus, office-based “minimally invasive” therapy is inherently attractive. The author sought to determine whether injection of peripheral trigeminal branches with neurolytic solutions offers a simple, less invasive therapy, with low risk for patients with one- or two-division trigeminal neuralgia that is unresponsive to pharmacotherapy.Methods. This retrospective study focused on a review of case charts from 18 patients treated for tic douloureux. Sixty injections of 10% phenol in glycerol were given to

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Lu, Jiafeng, Baolin Yang, Jiayi Liao, et al. "Olfactory Ensheathing Cells Alleviate Facial Pain in Rats with Trigeminal Neuralgia by Inhibiting the Expression of P2X7 Receptor." Brain Sciences 12, no. 6 (2022): 706. http://dx.doi.org/10.3390/brainsci12060706.

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Trigeminal neuralgia (TN) is a common facial neuropathic pain that is mainly characterized by spontaneous or induced needling or electric shock pain in the innervation area of the trigeminal nerve. It is also referred to as “the cancer that never dies”. The olfactory ensheathing cell (OEC) is a special glial cell in the nervous system that has a strong supportive function in nerve regeneration. Cell transplantation therapy is a useful treatment modality that we believe can be applied in TN management. In this study, OECs were transplanted into the ligation site of the infraorbital nerve of rat

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González-González, Ada María, Xabier A. Soto-Goñi, Fadi Hallal-Peche, and Eleuterio A. Sánchez-Romero. "Interdisciplinary approach in ophthalmic trigeminal neuralgia: A case report." Electronic Journal of General Medicine 22, no. 2 (2025): em640. https://doi.org/10.29333/ejgm/16073.

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<b>Introduction:</b> Trigeminal neuralgia (TN) is a severe pain disorder characterized by electric shock-like cramps and facial pain that is often triggered by innocuous stimuli. TN can be classified as classical, secondary, or idiopathic, with classical TN involving the vascular compression of the trigeminal nerve root. It is more prevalent in women and typically affects the right side of the face.<br /> <b>Case presentation:</b> A 38-year-old woman with persistent right facial pain experienced paroxysms near her right eye leading to headaches. Her medical histor

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Stidd, David A. "Peripheral Nerve Stimulation for Trigeminal Neuropathic Pain." Pain Physician 1;15, no. 1;1 (2012): 27–33. http://dx.doi.org/10.36076/ppj.2012/15/27.

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Facial pain is a complex disease with a number of possible etiologies. Trigeminal neuropathic pain (TNP) is defined as pain caused by a lesion or disease of the trigeminal branch of the peripheral nervous system resulting in chronic facial pain over the distribution of the injured nerve. First line treatment of TNP includes management with anticonvulsant medication (carbamazepine, phenytoin, gabapentin, etc.), baclofen, and analgesics. TNP, however, can be a condition difficult to adequately treat with medical management alone. Patients with TNP can suffer from significant morbidity as a resul

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Varela-Lema, Leonor. "Linear Accelerator Stereotactic Radiosurgery for Trigeminal Neuralgia." Pain Physician 18;1, no. 1;1 (2015): 15–27. http://dx.doi.org/10.36076/ppj/2015.18.15.

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Background: Stereotactic radiosurgery is accepted as an alternative for patients with refractory trigeminal neuralgia, but existing evidence is fundamentally based on the Gamma Knife, which is a specific device for intracranial neurosurgery, available in few facilities. Over the last decade it has been shown that the use of linear accelerators can achieve similar diagnostic accuracy and equivalent dose distribution. Objectives: To assess the effectiveness and safety of linear-accelerator stereotactic radiosurgery for the treatment of patients with refractory trigeminal neuralgia. Methods: We c

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Poydasheva, A. G., I. S. Bakulin, D. Yu Lagoda, N. A. Suponeva, and M. A. Piradov. "Effects and safety of high-frequency repetitive transcranial magnetic stimulation in trigeminal neuralgia." Neuromuscular Diseases 11, no. 2 (2021): 35–47. http://dx.doi.org/10.17650/2222-8721-2021-11-2-35-47.

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Background. Trigeminal neuralgia is the most common cause of facial pain. Insufficient effectiveness and frequent side effects of pharmacological therapy, as well as the risk of complications of invasive neurosurgical manipulations, determine the relevance of the development of new treatment approaches, one of which is repetitive transcranial magnetic stimulation (rTMS).The aim of the study is to determine the effectiveness of high‑frequency rTMS of the primary motor cortex in terms of pain intensity and quality of life in patients with trigeminal neuralgia, as well as to assess the safety of

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Little, Andrew S., Andrew G. Shetter, Mary E. Shetter, Curt Bay, and C. Leland Rogers. "LONG-TERM PAIN RESPONSE AND QUALITY OF LIFE IN PATIENTS WITH TYPICAL TRIGEMINAL NEURALGIA TREATED WITH GAMMA KNIFE STEREOTACTIC RADIOSURGERY." Neurosurgery 63, no. 5 (2008): 915–24. http://dx.doi.org/10.1227/01.neu.0000327689.05823.28.

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Abstract OBJECTIVE The long-term outcome of patients treated with gamma knife radiosurgery (GKRS) for typical trigeminal neuralgia has not been fully studied. We evaluated 185 patients who underwent their first GKRS treatment between 1997 and 2003 at the Barrow Neurological Institute. METHODS Follow-up was obtained by surveys and review of medical records. Outcomes were assessed by the Barrow Neurological Institute Pain Intensity Score and Brief Pain Inventory. The most common maximum dose was 80 Gy targeted at the root entry zone. Outcomes are presented for the 136 (74%) patients for whom mor

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Schürer, Qiong, Hamdy Shaban, Andreas R. Gantenbein, Giada Todeschini, and Saroj K. Pradhan. "Ashi Scalp Acupuncture in the Treatment of Secondary Trigeminal Neuralgia Induced by Multiple Sclerosis: A Case Report." Medicines 9, no. 8 (2022): 44. http://dx.doi.org/10.3390/medicines9080044.

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Background: Multiple sclerosis (MS) is an autoimmune, chronic, inflammatory, demyelinating, and axonal degeneration disease of the central nervous system. Trigeminal neuralgia (TN), a neuropathic facial paroxysmal pain, is prevalent among MS patients. Because of the inadequacy of the comprehension of MS-related TN pathophysiological mechanisms, TN remains arduous in its treatment approaches. Acupuncture as a non-pharmacological therapy could be a promising complementary therapy for the treatment of TN. MS gradual neural damage might affect the muscles’ function. This can lead to acute or parox

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Massager, Nicolas, José Lorenzoni, Daniel Devriendt, Françoise Desmedt, Jacques Brotchi, and Marc Levivier. "Gamma knife surgery for idiopathic trigeminal neuralgia performed using a far-anterior cisternal target and a high dose of radiation." Journal of Neurosurgery 100, no. 4 (2004): 597–605. http://dx.doi.org/10.3171/jns.2004.100.4.0597.

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Object. Gamma knife surgery (GKS) has emerged as a suitable treatment of pharmacologically resistant idiopathic trigeminal neuralgia. The optimal radiation dose and target for this therapy, however, remain to be defined. The authors analyzed the results of GKS in which a high dose of radiation and a distal target was used, to determine the best parameters for this treatment. Methods. The authors evaluated results in 47 patients who were treated with this approach. All patients underwent clinical and magnetic resonance imaging examinations at 6 weeks, 6 months, and 1 year post-GKS. Fifteen pote

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Slavik, E. E., B. M. Djurovic, D. V. Radulovic, et al. "Neurovaskularna kompresija (konflikt)." Acta chirurgica Iugoslavica 55, no. 2 (2008): 161–68. http://dx.doi.org/10.2298/aci0802161s.

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Since Dandy first reported vascular compression of the trigeminal nerve, the concept of neurovascular compression syndrome for trigeminal neuralgia and hemifacial spasm (HFS) has been accepted, and neurovascular decompression has been performed for this condition. The further investigations indicated that some other clinical syndromes such as glossopharyngeal neuralgia, disabling positional vertigo, tinnitus, geniculate neuarlgia, spasmodic torticolis, essential hypertension, cyclic oculomotor spasm with paresis and superior oblique myokymia also may be initiated by vascular compression of the

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Prüsse, Julya, Fernando André Campos Viana, Bruno Frota Amora Silva, and José Rômulo de Medeiros. "Uso da Toxina Botulínica Tipo A em pacientes com Neuralgia Trigeminal." Brazilian Journal of Dentistry and Oral Radiology 3, no. 1 (2024): bjd41. http://dx.doi.org/10.52600/2965-8837.bjdor.2024.3.bjd41.

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This article provides a systematic review of the efficacy of Botulinum Toxin Type A (TBA) in treating trigeminal neuralgia (TN), a painful disorder affecting the trigeminal nerve. TN is described in the literature as a facial pain of acute nature, often unilateral, characterized by episodes of intense and transient pain, comparable to electric shocks. The diagnosis is made through a detailed evaluation that includes anamnesis, characterization of symptoms, and imaging tests to exclude similar pathologies. Conventional therapy for TN involves the use of carbamazepine; however, in cases of pharm

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Tempel, Zachary J., Srinivas Chivukula, Edward A. Monaco, et al. "The results of a third Gamma Knife procedure for recurrent trigeminal neuralgia." Journal of Neurosurgery 122, no. 1 (2015): 169–79. http://dx.doi.org/10.3171/2014.9.jns132779.

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OBJECT Gamma Knife radiosurgery (GKRS) is the least invasive treatment option for medically refractory, intractable trigeminal neuralgia (TN) and is especially valuable for treating elderly, infirm patients or those on anticoagulation therapy. The authors reviewed pain outcomes and complications in TN patients who required 3 radiosurgical procedures for recurrent or persistent pain. METHODS A retrospective review of all patients who underwent 3 GKRS procedures for TN at 4 participating centers of the North American Gamma Knife Consortium from 1995 to 2012 was performed. The Barrow Neurological

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Khatun, Shohda, Ashis Kumar Biswas, Rajan Karmakar, Sojeeb Dhar, and Mst Mahbuba Kafia Parvin. "Study to assess the status of bupivacaine hydrochloride in the management of essential trigeminal neuralgia." Bangladesh Journal of Physiology and Pharmacology 26, no. 1-2 (2014): 30–33. http://dx.doi.org/10.3329/bjpp.v26i1-2.19965.

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Trigeminal neuralgia (TN) is a rare form of neuropathic facial pain characterized by severe paroxysmal pain in the face. The treatment of trigeminal neuropathic pain disorder is a major therapeutic challenge. Medical therapy often fails either due to poor responses to drugs or to unacceptable side effects and for those cases local anesthesia should be considered. Twenty patients (nine men and eleven women) who were diagnosed with TN previously and were not responsive to further medical treatment were selected for treatment. For this study, the affected nerve was blocked with 1.5 ml of 0.5% bup

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Ljubisavljevic, Srdjan. "The Rare Painful Phenomena – Chronic Paroxysmal Hemicrania-tic Syndrome as a Clinically Isolated Syndrome of the Central Nervous System." Pain Physician 2, no. 20;2 (2017): E315—E322. http://dx.doi.org/10.36076/ppj.2017.e322.

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The association of paroxysmal hemicrania with trigeminal neuralgia (TN) has been described and called paroxysmal hemicrania-tic syndrome (PH-tic). We report the case of a patient diagnosed as having chronic PH-tic (CPH-tic) syndrome as a clinically isolated syndrome of the central nervous system (CNS) (CIS). A forty year old woman was admitted to our hospital suffering from right facial pain for the last 2 years. The attacks were paroxysmal, neuralgiform, consisting of throb-like sensations, which developed spontaneously or were triggered by different stimuli in right facial (maxilar and mandi

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