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Dissertations / Theses on the topic 'Factors deficiency'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Bielecka, Monika. "Analysis of transcription factors under sulphur deficiency stress." Phd thesis, kostenfrei, 2007. http://opus.kobv.de/ubp/volltexte/2007/1481/.

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2

Ekman, Bertil. "IGF-I in growth hormone deficiency and in type 1 diabetes /." Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2002/med757s.pdf.

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3

Greene-Finestone, Linda. "Prevalence and risk factors of iron deficiency in infants." Thesis, University of Ottawa (Canada), 1986. http://hdl.handle.net/10393/4916.

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4

Furutani, Yuma. "Effects of Magnesium Deficiency on Expression of Myogenic Regulatory Factors." Kyoto University, 2011. http://hdl.handle.net/2433/142329.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第16131号<br>農博第1867号<br>新制||農||989(附属図書館)<br>学位論文||H23||N4601(農学部図書室)<br>28710<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)教授松井徹, 教授祝前博明, 教授今井裕<br>学位規則第4条第1項該当

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5

Piitulainen, Eeva. "Lung function in alpha1-antitrypsin deficiency register-based studies of its natural course and risk factors /." Malmö : Malmö University Hospital : Lund : Lund University, 1998. http://books.google.com/books?id=ZPprAAAAMAAJ.

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6

Adish, Abdulaziz A. "Risk factors and an assessment of control strategies for iron deficiency anemia in children in northern Ethiopia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ36948.pdf.

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7

Kargarnovin, Zahra. "Prevalence, risk factors and results of intervention among anaemic Iranian children in a low socio-economic community in urban Tehran." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298280.

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8

Lynch, Sean Martin. "Copper deficiency in the rat - sex differences and the influence of dietary factors." Thesis, University of Ulster, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328217.

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9

Chrisoulidou, Alexandra. "Effects of growth hormone treatment on intermediary metabolism and cardiovascular risk factors in adult hypopituitarism." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268361.

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10

Makhoul, Zeina. "Anemia and Iron Deficiency in Rural Nepali Pregnant Women: Risk Factors, Effect of Vitamin A Supplementation and Their Association with Birth Outcomes." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/193930.

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The objectives of the present study in rural Nepali pregnant women living in the terai were: 1) to identify the risk factors of severe anemia and investigate whether risk factors for anemia without iron deficiency, iron deficiency without anemia and iron deficiency anemia (IDA) were different; 2) to examine the effect of vitamin A supplementation, alone or combined with iron, on hemoglobin (Hb) and soluble transferrin receptor (sTfR); and 3) to identify the risk factors of low birth weight (LBW) and preterm delivery, focusing on maternal Hb concentrations. The prevalence of severe anemia (Hb <

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11

Cathcart, Angela Elizabeth. "Monitoring seasonal changes in factors affecting thiamin status in a Gambian village." Thesis, University of Ulster, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267822.

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12

George, Lena. "Spontaneous abortion : risk factors and measurement of exposures /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-921-1/.

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13

Shahvarani, Dani Ladan. "A study of dietary and non-dietary factors of iron deficiency anemia in HIV-positive women." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/12685.

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Anemia is one of the most common co-morbidities in human immunodeficiency virus (HIV), where approximately 50% of cases are attributed to iron deficiency anemia (IDA). IDA results from chronic inadequate iron supply to the body, whether through increased losses or decreased iron availability. In HIV, iron metabolism is greatly disrupted due to direct impacts of the virus, and therefore, prevalence of IDA is greater as compared to other populations. Women are at particularly high risk due to decreased dietary iron intakes, and increased losses due to menstruation and pregnancy. This study set o

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14

Crott, Jimmy. "The effects of folic acid deficiency and defects in folate metabolism on chromosome damage in vitro." Title page, table of contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phc9515.pdf.

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Reprints of the author's previously published articles included as an appendix. Bibliography: leaves 165-188. "This thesis describes a series of experiments that aimed to investigate the effects of folic acid deficiency and defects in folate metabolism on chromosome damage rates in human lymphocytes. The accumulation of chromosome damage over time is an important issue because it is thought to contribute to the mechanism of ageing and the aetiology of diseases of age such as cancer and Alzheimer's disease."

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15

Aljefree, Najlaa. "Association Between Vitamin D Status and Coronary Heart Disease Among Adults in Saudi Arabia: a Case-Control Study." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/365845.

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Accumulating evidence suggests that vitamin D deficiency and insufficiency may play a role in the development of coronary heart disease (CHD) and associated risk factors. Saudi Arabia has witnessed a growing epidemic of CHD and associated risk factors during the last few decades for several reasons, including the rapid changes in lifestyle and urbanization. Furthermore, national studies have demonstrated that vitamin D deficiency is highly prevalent in Saudi Arabia. Thus, it is crucial to examine the function of vitamin D in the prevention of CHD in Saudi Arabia. Therefore, the aim of this stu

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16

Sakala, Patricia. "Household consumption of orange - fleshed sweet potato and its associated factors in Chipata district, Eastern province, Zambia." University of the Western Cape, 2017. http://hdl.handle.net/11394/5644.

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Magister Scientiae (Nutrition Management) - MSc(NM)<br>Orange-fleshed sweet potato consumption promotion is one of the key nutrition sensitive interventions implementedto address high vitamin A deficiency among the rural population of Zambia since 2011. However, to date no study has been completed regarding household consumption of orange-fleshed sweet potato and factors related to their consumption. The study detailed here therefore sought to establish the consumption of orange-fleshed sweet potato, and to identify factors associated with its household consumption in the Integrating Orange Pr

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17

Bilousova, Ganna. "The role of impaired cellular fitness in leukemia promotion /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Biochemistry) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 137-161). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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18

Pourmoayyed, Parisa [Verfasser]. "The effect of sulfur deficiency in pea (Pisum sativum) on factors related to nitrogen fixation and on sulfate transporters / Parisa Pourmoayyed." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1122285817/34.

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19

Tufail, Adnan. "Relationship between haemorheological factors and cytomegalovirus load in the blood with cytomegalovirus retinitis in patients with the Acquired Immune Deficiency Syndrome." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391638.

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20

CERQUEIRA, Vilma Maria Pereira Ramos de. "Anemia e fatores associados em lactentes usuários da estratégia saúde da família no município de Olinda-Pernambuco." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/17971.

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Submitted by Natalia de Souza Gonçalves (natalia.goncalves@ufpe.br) on 2016-10-10T12:39:43Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) DISSERTAÇÃO FINAL CATALOGADA.pdf: 2214904 bytes, checksum: f91f58cb9f05ba1bd3491bc133ea4401 (MD5)<br>Made available in DSpace on 2016-10-10T12:39:43Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) DISSERTAÇÃO FINAL CATALOGADA.pdf: 2214904 bytes, checksum: f91f58cb9f05ba1bd3491bc133ea4401 (MD5) Previous issue date: 2014-09-11<br>Capes<br>A anemia é consid

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Low, Adrian Kah Wai Clinical School Prince of Wales Hospital Faculty of Medicine UNSW. "The molecular biology of cancellous bone defects and oestrogen deficiency fractures, in rodents; and the in vivo effects of acid on bone healing." Publisher:University of New South Wales. Clinical School - Prince of Wales Hospital, 2008. http://handle.unsw.edu.au/1959.4/42884.

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The management of significant bone defects, delayed and non-union of fractures can be extremely challenging. Development of specific treatment is hindered by an absence of information regarding the molecular events which regulate these processes. In this thesis, a bilateral cancellous bone defect model of the femur and tibia was developed in a rodent and the spatiotemporal profile of TGF-β, BMP 2 and 7, Smads 1, 4 and 5 characterised. Next, the capability of acid solution to augment healing was tested in both a bone defect and in a closed femoral fracture model. Finally, a long term oestrogen

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22

AMBROGI, JÉSSICA B. "Avaliação dos teores de elementos essenciais e tóxicos em alimentos da dieta da população de São Paulo, segundo a POF 2008-2009." reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26826.

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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2016-11-11T17:02:12Z No. of bitstreams: 0<br>Made available in DSpace on 2016-11-11T17:02:12Z (GMT). No. of bitstreams: 0<br>O Estudo de Dieta Total (EDT) tem sido recomendado pela Organização Mundial da Saúde como o método mais adequado para estimar as ingestões dietéticas de contaminantes e nutrientes para um país ou grandes grupos populacionais. O presente estudo é o segundo realizado no Brasil, atualizado com dados da Pesquisa de Orçamento Familiar-POF 2008-2009 do IBGE, para avaliação de ingestão dietética dos elementos essenciais e

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23

Ainscough, Sarah Louise. "Improved strategies for the cultivation of human limbal epithelial (HLE) grafts." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/18575/1/Sarah%20Ainscough%20Thesis.pdf.

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The limbal stem cell population is located in the limbal junctional zone between the cornea and the conjunctiva, and is responsible for maintaining the corneal epithelium. Damage to the limbal stem cell population results in a condition known as limbal stem cell deficiency (LSCD), which is characterised by conjunctivalisation of the cornea, visual impairment and persistent irritation. To treat LSCD, an alternative source of human limbal epithelial (HLE) cells must be transplanted back onto the diseased cornea. Limbal tissue grafts have had a moderate degree of success. However, autologous graf

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24

Ainscough, Sarah Louise. "Improved strategies for the cultivation of human limbal epithelial (HLE) grafts." Queensland University of Technology, 2008. http://eprints.qut.edu.au/18575/.

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The limbal stem cell population is located in the limbal junctional zone between the cornea and the conjunctiva, and is responsible for maintaining the corneal epithelium. Damage to the limbal stem cell population results in a condition known as limbal stem cell deficiency (LSCD), which is characterised by conjunctivalisation of the cornea, visual impairment and persistent irritation. To treat LSCD, an alternative source of human limbal epithelial (HLE) cells must be transplanted back onto the diseased cornea. Limbal tissue grafts have had a moderate degree of success. However, autologous graf

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25

Lôbo, Ivon Pinheiro. "Desenvolvimento de método cromatográfico para quantificação de alquil ésteres em amostras de biodiesel." Instituto de Química, 2010. http://repositorio.ufba.br/ri/handle/ri/20289.

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Submitted by Ana Hilda Fonseca (anahilda@ufba.br) on 2016-09-08T14:22:01Z No. of bitstreams: 1 Tese de Doutorado - Ivon P. Lôbo.pdf: 3344901 bytes, checksum: 7e73b89d7c92c4df99ab47eb630bca7c (MD5)<br>Approved for entry into archive by Vanessa Reis (vanessa.jamile@ufba.br) on 2016-09-08T14:40:02Z (GMT) No. of bitstreams: 1 Tese de Doutorado - Ivon P. Lôbo.pdf: 3344901 bytes, checksum: 7e73b89d7c92c4df99ab47eb630bca7c (MD5)<br>Made available in DSpace on 2016-09-08T14:40:02Z (GMT). No. of bitstreams: 1 Tese de Doutorado - Ivon P. Lôbo.pdf: 3344901 bytes, checksum: 7e73b89d7c92c4df99ab47eb

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26

Barros, Ana Cláudia Mamede Wiering de. "Proteção e vulnerabilidade à violência familiar em crianças e adolescentes com deficiências." Instituto Fernandes Figueira, 2014. https://www.arca.fiocruz.br/handle/icict/10947.

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Made available in DSpace on 2015-06-22T12:29:53Z (GMT). No. of bitstreams: 2 license.txt: 1914 bytes, checksum: 7d48279ffeed55da8dfe2f8e81f3b81f (MD5) ana_claudia_mamede_wiering_de_barros_iff_dou_2014.pdf: 1615247 bytes, checksum: 74bd71544ec9b771f136f79680fbb6d1 (MD5) Previous issue date: 2014<br>Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Ensino. Programa de Pós-Graduação em Saúde da Criança e da Mulher. Rio de Janeiro, RJ, Brasil.<br>O objetivo deste trabalho foi o de analisar as condições de proteção e de v

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27

Wagener, Iris Elisabeth. "Prävalenz und Risikofaktoren von Eisenmangel bei jungen Müttern." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/14593.

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Lebensqualität und Leistungsfähigkeit werden durch einen unbemerkten Eisenmangel beeinträchtigt. Frauen im gebärfähigen Alter haben einen erhöhten Eisenbedarf, der in der Schwangerschaft noch zunimmt. Ziel der Untersuchung war, die Prävalenz von Eisenmangel bei Müttern unter deutschen Lebensbedingungen zu evaluieren. Der Eisenstatus von 507 Müttern wurde zwischen September 1997 und August 1998 untersucht. Datenquellen waren venöse Blutentnahme und Fragebogen. Neben konventionellen Messgrößen wurde eine erhöhte Konzentration des löslichen Transferrinrezeptors als Leitindikator für einen Eisenma

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28

Moratioa, Gugulethu. "Psychosocial factors that affect adherence to antiretroviral therapy amongst HIV/AIDS patients at Kalafong hospital." Diss., Pretoria : [s.n.], 2008. http://upetd.up.ac.za/thesis/available/etd-08052008-122226.

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29

Spies, Margaretha. "The biopsychosocial factors influencing HIV/AIDS patient adherence to Antiretroviral Therapy (ART) a Social Work study /." Thesis, Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-08112008-165506.

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30

Vesna, Vasić. "Folna kiselina u terapiji depresivnog poremećaja." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2014. http://www.cris.uns.ac.rs/record.jsf?recordId=87827&source=NDLTD&language=en.

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Cilj ovog istraživanja je bio da se utvrdi nivo folne kiseline u serumu (fiziolo&scaron;ka vrednost je od 16,31 do 34,88 nmol/l) i proceni težina kliničke slike instrumentima kliničke procene (HAMD 17 i 21, MADRS i CGI skala) u populaciji bolnički lečenih pacijenata, koji boluju od te&scaron;ke depresivne epizode, ili rekurententog depresivnog poremećaja, i njihov odgovor na inicijalnu antidepresivnu terapiju sprovođenu prema smernicama nacionalnog vodiča. Odgovor na antidepresivnu terapiju je određivan nakon četiri i osam nedelja lečenja u odnosu na nivo folne kiseline i prema nadoknadi folne

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31

Silva, Alliny Beletini da. "PREVALÊNCIA DE DEFICIÊNCIA DE VITAMINA D E ANÁLISE DOS FATORES ASSOCIADOS EM CRIANÇAS SAUDÁVEIS DO AMBULATÓRIO DE PEDIATRIA DO HUSM." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/5867.

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Vitamin D deficiency is one of the most commented health issues at the moment, given the number of discoveries about its function in various tissues and organs. The principal action of vitamin D is related to calcium absorption and its implication in bone homeostasis, but, besides this, it has been implicated in several other diseases. Despite this huge interest in vitamin D, there are still few studies talking about vitamin D deficiency in children in our country, and especially in our region. Knowing the prevalence of vitamin D deficiency in specific place or region, it will be possible plan

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32

Pickering, Matthew Caleb. "Glomerulonephritis and factor H deficieny." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252096.

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33

Hussain, Abid. "Impact of LYL1 deficiency on adipocyte differentiation." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS061.

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LYL1 (Lymphoblastic leukemia-derived sequence 1) est un facteur de transcription basic hélice-boucle-hélice (bHLH) exprimé dans les lymphocytes B, les cellules myéloïdes et les cellules endothéliales (CE). Les souris déficientes pour Lyl1 (Lyl1-/-) sont viables et chez la souris adulte, LYL1 a un rôle majeur dans la maturation des vaisseaux sanguins nouvellement formés et dans le contrôle de la perméabilité vasculaire basale, suggérant l'importance de LYL1 dans le maintien de la quiescence et/ou stabilisation des CE. Les vaisseaux sanguins représentent une barrière entre le sang et le tissu co

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34

Uprichard, William James Nicolas. "Molecular and structural analysis of human Factor X deficiency." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446783/.

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Factor X (FX) is one of the vitamin K-dependent serine proteases, and is g of a catalytic serine protease domain, two EGF domains and a Gla domain. It is crucial for coagulation, however its role in disease has not been fully characterised. This thesis describes the phenotypic and genotypic analysis of kindred with FX deficiency. Because FX deficiency is rare in the general population, patient samples were drawn from across the world. Laboratory assays for FX and direct sequencing of the gene were performed on samples from ten kindred. A total of ten mutations were identified, nine of which we

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35

Frise, Matthew. "Iron deficiency and human hypoxia physiology." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:a6cbaa64-eed4-43db-8a2f-2826e6bbd249.

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This thesis is concerned with a very common disorder of iron homeostasis: iron deficiency. The specific focus is the manner in which iron deficiency influences physiological responses to hypoxia in humans. This work is predicated on observations made over many decades in vitro and in vivo, suggesting that variations in the bioavailability of iron have important consequences for certain biological processes known to depend on oxygen availability. Three separate but related studies together form the basis for this thesis. The first two, Study A and Study B, adopt a similar approach in recruiting

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36

Hernandez, Maria Genevieve H. "The Role of CD40 in Naïve and Memory CD8+ T Cell Responses: a Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/346.

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Stimulation of CD40 on APCs through CD40L expressed on helper CD4+ T cells activates and “licenses” the APCs to prime CD8+ T cell responses. While other stimuli, such as TLR agonists, can also activate APCs, it is unclear to what extent they can replace the signals provided by CD40-CD40L interactions. In this study, we used an adoptive transfer system to re-examine the role of CD40 in the priming of naïve CD8+ T cells. We find an approximately 50% reduction in expansion and cytokine production of TCR-transgenic T cells in the absence of CD40 on all APCs, and on dendritic cells in particular. M

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Golińska, Monika Anna. "The molecular and metabolic adaptations of HIF-1β deficient tumour cells". Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609977.

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38

Lima, Daniela Braga. "Anemia e deficiência de vitamina A em crianças brasileiras." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/7/7141/tde-05112014-104916/.

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Introdução: Dentre as carências nutricionais de maior relevância destacam-se, neste estudo, anemia e deficiência de vitamina A, que constituem as principais preocupações das políticas públicas, na área de alimentação e nutrição. Apesar de medidas de prevenção e controle já terem sido implantadas no Brasil há algum tempo, suas prevalências continuam elevadas, com profundas repercussões na saúde infantil. Assim, embora reconhecidos como problemas de saúde pública e bastante explorados, politicamente, ainda há espectros de interesse epidemiológico a serem investigados. Objetivo: Analisar os deter

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39

Araújo, Claudia Regina Marchiori Antunes. "Determinantes da anemia em mães e filhos no Brasil." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/7/7141/tde-27082012-144304/.

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Introdução: Anemia por carência alimentar de ferro é a deficiência nutricional mais freqüente e preocupante do ponto de vista da saúde coletiva. Afeta principalmente crianças, gestantes e mulheres em idade fértil. Apesar das medidas de intervenção para prevenção e controle da anemia no Brasil, estudos mostram que as prevalências ainda continuam elevadas. Objetivo: Investigar a situação da anemia e seus determinantes em mães e filhos no Brasil, considerando o contexto familiar. Método: Pesquisa transversal de abordagem quantitativa, que utilizou o banco de dados da Pesquisa Nacional de Demograf

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Bolton-Maggs, Paula H. B. "Phenotype and molecular genetics of factor XI deficiency in the United Kingdom." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491905.

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A new bleeding disorder was described in 1953 in which the bleeding symptoms were present in both males and females. It was differentiated from haemophilia A and B by plasma mixing studies. Early clinical and family studies of this disorder, factor XI deficiency, were limited to a small number of families, some described before a reliable factor XI:C assay was developed. In 1985 a study was made of 24 families with factor XI deficiency in North London, . followed by a more extensive study of 30 families in North West England. These two studies confirmed the mode of inheritance (autosomal) but

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Mitchell, Michael John. "The molecular basis of factor XI deficiency : a study of structure/function relationships." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440457.

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42

Moreira, Michele. "Análise do gene OTX2 em pacientes com a deficiência de hormônio de crescimento isolada ou associada a outras deficiências hormonais hipofisárias." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-20052013-093843/.

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Introdução: A incidência de baixa estatura devido a deficiência do hormônio do crescimento (DGH) ocorre em 1:4.000-10.000 nascidos vivos. Diversos fatores de transcrição são necessários para a diferenciação dos cinco tipos de células produtoras de 6 hormônios hipofisários. Mutações nos fatores de transcrição HESX1, GLI2, LHX3, LHX4, SOX2, SOX3, PROP1 e POU1F1 foram descritas em pacientes com deficiência hormonal hipofisária isolada ou múltipla associada ou não a outras malformações. Mutações no gene OTX2, um fator de transcrição responsável pela formação da vesicula ocular e pela hipófise, pod

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O'Connell, N. M. "Factor XI deficiency : a study of clinical, laboratory and molecular modifiers of bleeding phenotype." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1324551/.

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Factor XI (FXI) is a plasma glycoprotein that participates in the consolidation phase of blood coagulation and is important in the creation of a stable fibrin clot. Deficiency of FXI leads to an injury-related bleeding diathesis, which is notable for the variability in the bleeding tendency and the lack of a clear relationship between bleeding and FXI coagulant activity (FXI:C). A comprehensive understanding of the factors which influence the bleeding tendency in factor XI deficiency would enable a more structured evaluation of bleeding risk and would focus the treatment choices for individual

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Hamade, Fares. "Enhanced bone formation during distraction osteogenesis in FGFR3 deficient mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112630.

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Distraction Osteogenesis (DO) is a technique for bone lengthening and filling of bone defects following trauma, infection or resection of tumors. DO consists of an osteotomy of the bone to be lengthened, followed by controlled distraction of the bone segments with an external fixator until the desired lengthening is obtained (distraction phase). This is followed by the consolidation phase, during which the external fixator is kept in place until the newly formed bone in the distracted zone consolidates. This phase is long and may cause numerous problems. Ongoing research aims at finding a meth

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Lu, Yarong 1971. "Pancreatic-specific insulin-like growth factor I gene deficiency on islet cell growth and protection." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111827.

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The role of insulin-like growth factor I (IGF-I) in pancreatic islet cell growth and development has been debated in recent years. The dogma that IGF-I stimulates pancreatic islet growth has been challenged by combinational targeting of IGF or IGF-IR genes, as well as beta-cell-specific IGF-IR gene deficiency. In order to assess the physiological role of locally produced IGF-I, we have developed pancreatic-specific IGF-I gene deficiency (PID) by crossing Pdx1-Cre and IGF-I/loxP mice. PID mice were normal except for decreased blood glucose level and a 2.3-fold enlarged islet cell mass. When cha

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Okhrimenko, Albert N. "ULTRAFAST EXCITED STATE RELAXATION DYNAMICS OF ELECTRON DEFICIENT PORPHYRINS: CONFORMATIONAL AND ELECTRONIC FACTORS." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1126888140.

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Lu-Nguyen, Ngoc Bao. "Integration-deficient lentiviral vectors delivering neurotrophic factors for gene therapy of Parkinson's disease." Thesis, Royal Holloway, University of London, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604022.

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Parkinson's disease (PD) results from the loss of nigra I dopaminergic neurons and subsequent depletion of striatal dopamine. Direct injection of neurotrophic factors has shown encouraging protection in animal models of PD. However, clinical delivery of protein requires administration by implanted mini-pumps, with associated surgical risks. Hence, a novel integrotiondeficient lentiviral vector (IDLV) system, with an improved biosafety. profile, was introduced. Initial experiments examined whether transduction efficiency of IDLVs was comparable with that of the standard integration-proficient l

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Nelson, Nadine D. "Ikaros Deficiency Leads To An Imbalance in Effector and Regulatory T Cell Homeostasis in Murine Pancreatic Cancer." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5810.

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Pancreatic cancer is one of the deadliest cancers with a five-year survival rate of 6%. Pancreatic cancer is resistant to conventional chemotherapy and is usually diagnosed at late stages. Current treatment options have minimal effects in extending patients' lives beyond 10 months. One significant limitation in developing treatments to combat pancreatic cancer is its immunosuppressive microenvironment. Pancreatic cancer secretes factors that activate immunosuppressive cells, such as regulatory T cells (Tregs). These Tregs suppress effector CD4+ and CD8+ T cell anti-tumor immune responses. Ther

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Advani, Tushar M. "Brain derived neurotrophic factor deficient mouse a putative model of allostatic overload : a dissertation /." San Antonio : UTHSC, 2008. http://proquest.umi.com.libproxy.uthscsa.edu/pqdweb?did=1588771861&sid=7&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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Aslam, Shazia. "Inherited factor XIII a subunit deficiency : analysis of gene mutations and their effect on structure and function." Thesis, University of the West of England, Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342670.

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