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1

Mouasni, Sara. "Implication de l'inflammasome NLRP3 dans la sécrétion non conventionnelle de la protéine FADD The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding FADD at the crossroads between cancer and inflammation." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB121.

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FADD (FAS-Associated Death Domain) est la protéine adaptatrice clé de l'apoptose via les récepteurs de mort. Elle est également impliquée dans d'autres types de mort cellulaire, mais aussi dans des mécanismes de survie, la prolifération et le cycle cellulaire. C'est donc une protéine régulatrice de la vie et de la mort et un changement de son expression peut avoir de graves conséquences physiopathologiques. Par exemple, l'équipe a montré que l'expression de la protéine FADD pouvait être perdue dans des biopsies de cancer du poumon et que cette perte était corrélée à la sécrétion de la protéine
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Schaub, Friedemann. "Fas/FADD-induced pro-inflammatory response in vascular smooth muscle cells /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/6345.

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Vilmont, Valérie. "Nouvelles voies de régulation des localisations intra- et extra-cellulaires de la protéine FADD." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T003.

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La protéine FADD (Fas associated death domain) est l’adaptateur clé de la voie de signalisation apoptotique dépendante des récepteurs de mort de la famille du TNF (tumor necrosis factor). Au cours des dix dernières années, il est apparu évident qu’au-delà de son rôle majeur dans la mort cellulaire, FADD est impliqué dans d’autres processus biologiques comme le développement embryonnaire, la réponse immunitaire innée ou encore la progression du cycle cellulaire. De même, il est devenu clair que la localisation subcellulaire de FADD est déterminante pour sa fonction. Identifier les voies de régu
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Jensen, Kirsten Ellerup. "The role of PML and PML nuclear bodies in FADD-mediated apoptosis." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/42250.

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PML nuclear bodies (NBs) consist of more than 80 constituents and are involved in many cellular processes such as apoptosis, DNA repair, cell cycle, transcriptional regulation and development. PML NBs are associated with the 'nuclear matrix' and vary in size from 0.3 to 1.0 !m in diameter. PML NBs came to prominence when PML, expressed as an oncogenic fusion protein with the retinoic acid receptor, was found in patients with acute promyelocytic leukaemia. PML is the major PML NB constituent and is involved in cellular activities such as apoptosis, growth suppression, antiviral defence and DNA
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Sonuc, Niluefer. "C- jun downregulation sensitizes hepatoma cells to receptor induced apoptosis through preventing FADD phosphorylation." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-106724.

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Hyun, Jinhee. "RIP1 and FADD's Role in Innate Immunity." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/519.

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Rapid production of type I Interferon is pivotal to initiate cellular antiviral host defense and adaptive immunity. In order to facilitate innate immune processes, a cell harbors pattern recognition receptors (PRRs) which sense distinctive forms of pathogen associated molecular patterns (PAMPs). For example, Toll like receptors (TLRs) and RIG-I like receptors (RLRs) were discovered as PRRs for pathogen derived molecules and the production of type I Interferon (IFN). To induce type I IFN, several transcription factors such as nuclear factor-kappaB (NF-ĸB), interferon regulatory factor 3 (IRF3),
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Winther, Kasper. "Identification of cGAS-like receptors and characterization of STING mediated NF-κB activation in Drosophila melanogaster". Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ038.

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STING est un régulateur de l'immunité innée conservé au cours de l'évolution. La première partie décrit l'identification chez la mouche drosophile de récepteurs de type cGAS, qui reconnaissent l'ARN double brin viral et produisent divers dinucléotides cycliques (DNC) activant STING. La deuxième partie révèle que, bien que les voies IMD antibactérienne et STING antivirale signalent indépendamment via les protéines IMD et STING, elles convergent vers l’adaptateur dFADD et la caspase Dredd, entraînant le clivage et l'activation du facteur de transcription NF-κB Relish. Ce processus est médié par
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Tamannai, Mona [Verfasser]. "ING1 ist in die durch TSA induzierte Apoptose und in den FADD/Caspase-3-Signalweg in humanen Glioblastomzellen involviert / Mona Tamannai." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2007. http://d-nb.info/1022581902/34.

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Parker, Jeffery Todd. "Bartonella Henselae Inhibits Cellular Apoptotic Regulators to Ensure Survival." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/biology_diss/68.

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Human pathogens survive anti-pathogen host immune assault by either circumventing or evading the host immune response. Bartonella henselae, an intracellular pathogen previously shown to disrupt intrinsic apoptotic messengers to enhance its survival, exploits multiple facets of the cellular apoptotic mechanisms. Cellular pathways affected by apoptotic processes were assessed using real-time reverse-transcriptase-polymerase-chain-reaction (rRT-PCR) to measure the effect of B. henselae on cell regulator gene expression (TRADD, FADD, caspase-8 and caspase-3), caspase activity, DNA cell cycle analy
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10

Pawar, Pritish Subhash. "Calmodulin binding to cellular FLICE like inhibitory protein modulates Fas-induced signaling and tumorigenesis in cholangiocarcinoma." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/pawar.pdf.

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Welz, Patrick-Simon [Verfasser], Manolis [Akademischer Betreuer] Pasparakis, and Jonathan C. [Akademischer Betreuer] Howard. "In vivo analysis of the role of FADD in the regulation of intestinal epithelial homeostasis / Patrick-Simon Welz. Gutachter: Manolis Pasparakis ; Jonathan C. Howard." Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/103822750X/34.

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Cagnol, Sébastien. "Contrôle de la mort cellulaire par la voie des MAPK1/3 (ERK2/1)." Phd thesis, Université de Nice Sophia-Antipolis, 2005. http://tel.archives-ouvertes.fr/tel-00104792.

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La mort cellulaire programmée ou apoptose est un mécanisme conservé chez les eucaryotes multicellulaires qui contribue au développement embryonnaire et à l'homéostasie cellulaire des organismes. Dans les cellules vivantes, l'activité des protéases qui exécutent le programme de mort cellulaire, les caspases, est contrôlée par des signaux de survie provenant de l'environnement cellulaire. Les caspases initiatrices de l'apoptose régulée par l'environnement, la caspase 9 et la caspase 8 sont activées respectivement par l'apoptosome et par les récepteurs de mort. Les signaux environnementaux, parmi
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Beckmann, Anyka [Verfasser]. "Proteinexpression der an der Signaltransduktion durch TNF alpha beteiligten Proteine FADD, TRADD, TRAF2 und RIP in humanen Leukozyten bei Patienten mit schubförmiger Multipler Sklerose / Anyka Beckmann." Gießen : Universitätsbibliothek, 2014. http://d-nb.info/1068591676/34.

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14

Holmberg, Erica, and Helena Andersson. "CSR - here to stay or a fad that will fade away?" Thesis, Jönköping University, JIBS, EMM (Entrepreneurship, Marketing, Management), 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-541.

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<p>There is a shift of values in the Western society of today from material to immaterial values Löhman and Steinholtz (2003). This changes together with the interest among people in Sweden and in the rest of the Western world to travel and experience new cultures the developing world has come closer. This has raised the awareness of the role of companies re-garding social responsibility since most companies have suppliers, producers or some other kind of involvement in developing countries. Today several companies are engaged in corporate social responsibility (CSR) issues. However, the topic
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Dishmon, Monja. "cFLIP regulates Fas-induced apoptosis and pro-inflammatory gene expression in human vascular smooth muscle cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/6341.

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Weber, Judith [Verfasser], та Andreas [Gutachter] Kerstan. "Immunhistochemische Analysen zur Expression von cellular FLICE (FADD-like-IL-1β-converting enzyme)-inhibitory protein (cFLIP) in epithelialen und melanozytären Tumoren der Haut / Judith Weber ; Gutachter: Andreas Kerstan". Würzburg : Universität Würzburg, 2020. http://d-nb.info/1217195351/34.

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Bolze, Alexandre. "La découverte de l’origine génétique de l’asplénie congénitale isolée chez l’homme." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T024/document.

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L’asplénie ou l’absence de la rate peut être congénitale, c’est- à -dire absente dès la naissance, ou bien acquise, par exemple lors d’une opération après un accident. L’asplénie congénitale est le plus souvent associée à d’autres problèmes développementaux. En particulier l’asplénie congénitale est associée à des problèmes de développement du cœur, dans le cadre des syndromes d’hétérotaxie. Ces syndromes d’hétérotaxie sont caractérisés par des problèmes de latéralité droite-gauche. Ainsi une personne ayant deux parties ‘droites’ n’aura pas de rate. A contrario, l’asplénie congénitale isolée e
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18

Rühlmann, Martha Ewa [Verfasser]. "Genexpression verschiedener an der Signaltransduktion der TNF-Rezeptoren beteiligter Komponenten bei Patienten mit verschiedenen Verlaufsformen der multiplen Sklerose : Etablierung einer quantitativen RT-PCR zur Analyse der Genexpression von TRADD und FADD in humanen Leukozyten / Martha Ewa Rühlmann." Gießen : Universitätsbibliothek, 2012. http://d-nb.info/1063953804/34.

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Miyahara(Kotone), Yasuko. "Short-term delay of Fas-stimulated apoptosis by GM-CSF as a result of temporary suppression of FADD recruitment in neutrophils : evidence implicating phosphatidylinositol 3-kinase and MEK1-ERK1/2 pathways downstream of classical protein kinase C." Kyoto University, 2005. http://hdl.handle.net/2433/144745.

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Reno, Christopher Wayne. "Faded glory." Thesis, University of Iowa, 2011. https://ir.uiowa.edu/etd/1065.

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The life and times of Christopher Wayne Reno, as they relate to his years at the University of Iowa, are presented within the pages of this small but potent document. Reader beware: once you've cracked this tome and experienced the wonders within, your view of the world will be fundamentally altered. Your life may no longer hold its current luster. I urge caution!
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Aldhahyani, Ammar. "Implementation of FaDO in React.js : Implementation of FaDO in React.js." Thesis, Uppsala universitet, Institutionen för informationsteknologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438670.

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This report describes the implementation of FaDO as a REACT.JS web-based tool. FaDO is a machine learning method for real-time fraud detection: it flags (financial)transactions as either fraudulent or normal in a real-time fashion. FaDO implementssemi-supervised machine learning for this task: in semi-supervised learning, only a small portion of the presented data needs to be labeled. This tool is designed as a filter that works together both with existing automatic fraud filters and human experts. The contribution of this work is a dynamical webpage that implements and demonstrates the approa
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Maye, Sylvia Renee. "Fade to Black." University of Dayton / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1354302272.

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Panciarelli, Antonio. "A ordem natural do fado: discurso e personagem em fado alexandrino." Pontifícia Universidade Católica de São Paulo, 2006. https://tede2.pucsp.br/handle/handle/14781.

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Made available in DSpace on 2016-04-28T19:58:59Z (GMT). No. of bitstreams: 1 ANTONIO PANCIARELLI.pdf: 397710 bytes, checksum: 539e93eacb11b3e3f0399c3f554bf192 (MD5) Previous issue date: 2006-05-24<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>This dissertation belongs to area of literature and literary criticism and deals specifically about analysis of Romanesque prose in Fado Alexandrino, by António Lobo Antunes. In this study, we sought to make an immanent analysis of the work, however without disregarding the ideological, political, historical and social aspects that p
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Rodger, Amber N. "The Challenges of Fetal Alcohol Spectrum Disorder (FASD) to Sentencing: A Comparative Analysis of FASD and Non-FASD Sentencing Judgments." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31014.

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The cognitive and/or behavioural problems associated with Fetal Alcohol Spectrum Disorder (FASD) place this population at increased risk of involvement in the justice system. Although FASD poses challenges at each stage of the justice system, legal discussion and commentary have pinpointed the sentencing stage as the phase in which the issue of FASD is most commonly raised and considered. The purpose of this study is to examine if (and how) FASD is being taking into consideration at sentencing. To this end, a comparative analysis of 87 sentencing judgments (42 FASD offenders and 45 non-FASD of
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Wilson, Steven L. (Steven Lawrence). "Fade Away: A Novel." Thesis, University of North Texas, 1993. https://digital.library.unt.edu/ark:/67531/metadc500325/.

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The struggle for survival of an American family revolves around Mitch Wilcox, a relief pitcher for a fictional major league baseball team. Nearing the end of his long career, he must decide whether to retire or to sign a new contract. His dilemma centers on his wife, Nicole, who argues for his retirement; and his only child, Twylight, who has run away from home. The novel traces the final two weeks of a season, during which Mitch's team battles for a pennant and he delays his decision because of events that expose the precarious nature of both his professional and personal identities. During a
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Felisberto, Filipa Jardim Duarte. "Fado… um estado de alma." Master's thesis, ISPA - Instituto Universitário, 2013. http://hdl.handle.net/10400.12/2314.

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Dissertação de Mestrado apresentada ao ISPA - Instituto Universitário, na especialidade de Psicologia Clínica.<br>O Fado, sendo um produto da criatividade do sujeito, constitui uma forma de comunicação e relação. Propõe-se refletir e compreender a ligação existente entre o Fado e o sujeito, de forma a averiguar se existe uma relação/função psicológica entre ambos. Procurou-se contextualizar o Fado, enquadrando-o historicamente e definindo-o como expressão musical. Abordou-se o Fado nas suas múltiplas vertentes: a música, a palavra, a emoção e o sentimento, a identidade e o destino, delimitand
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Visagie, Morne. "The last colour to fade." Master's thesis, Faculty of Humanities, 2019. https://hdl.handle.net/11427/31802.

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Drawing on personal recollections and collective history, The Last Colour to Fade offers a meditation on the sea as both a physical and psychological landscape. Memories of my childhood spent on Robben Island are interwoven with historical facts, with narratives borrowed from literature and film, and images from art and life. Shifting between first person and third, between my own reflections and those of others, I have found in the lives and works of Adriaan Van Zyl, Derek Jarman, Jean Genet, Virginia Woolf and others a shared affinity for water. The sea – changeable, inconstant – rev
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Aejmelaeus-Lindström, Petrus. "FAD* for Stadsgårdskajen." Thesis, KTH, Arkitektur, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-159076.

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FAD * for Stadsgårdskajen Re-introduction of some of the knowledge from the master builder to the contemporary architect. This project investigates the interaction between designing architecture and building architecture in a computer controlled context. Algorithms have been developed to simulate and control an automated in situ brick stacking process. Brick laying is a well researched topic for robotic processes. It is an ideal material for building with robots (in Stockholm) since it is a generic building block that is cheap and easy to produce locally. Corbeled vaults, instead of keystone v
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Schaffer, Paul. "Grain refiner fade in aluminium alloys /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18566.pdf.

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Filip, Miodrag. "Adaptive modulation as a fade countermeasure." Thesis, University of Portsmouth, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481582.

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Al-Deb'i, Fadi [Verfasser]. "Überseekauf und Abladegeschäft. / Fadi Al-Deb'i." Berlin : Duncker & Humblot, 2010. http://d-nb.info/1238358837/34.

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Faria, Catarina Machado. "Fado Tropical. O Fado na emigração portuguesa e lusodescendência no Rio de Janeiro e em São Paulo." Master's thesis, Faculdade de Ciências Sociais e Humanas, Universidade Nova de Lisboa, 2012. http://hdl.handle.net/10362/9444.

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Trabalho de Projeto apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Culturas Visuais<br>O presente estudo procura entender de que forma o Fado, como expressão musical que se institui como um símbolo da identidade nacional portuguesa, é percecionado pelos indivíduos ou grupos de emigrantes portugueses ou lusodescendentes residentes no Rio de Janeiro e em São Paulo. É objetivo perceber se o Fado se constitui, por um lado, como um recurso identitário de afirmação étnica perante a comunidade brasileira e, por outro lado, como fator que estimula a coesão entr
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Ajaz, Haroon. "Study of fade and inter-fade durations in Ku- and Ka- band frequencies using OLYMPUS satellite beacons." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-12042009-020112/.

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De, Campos Reis Simone. ""Abracadabra" A palavra dos contos de fada." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/7340.

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Made available in DSpace on 2014-06-12T18:31:35Z (GMT). No. of bitstreams: 2 arquivo3707_1.pdf: 601664 bytes, checksum: 753871396fe0298f659fa25df0ce6d39 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2008<br>Este trabalho apresenta um estudo exploratório do léxico como uma proposta para a expansão do vocabulário de uma língua estrangeira, neste caso específico, da língua inglesa. Os substantivos, adjetivos e verbos são palavras que possuem um componente semântico muito forte e são enriquecidas de forma contínua à medida que acompanham
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Zubeck, Stella. "Not Fade Away : Enriching Music Festival Audience Experience." Research Showcase @ CMU, 2014. http://repository.cmu.edu/theses/77.

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The modern music festival is a site of interaction between up to hundreds of thousands of people, artists, vendors, musicians and technologies. Audiences travel thousands of miles and invest huge amounts of time, energy and money to attend them. Despite the increasing commercial demand for music festivals and the budding recognition of their social value to festivalgoers, humancentered design methods have not been applied to explore ways to increase the value of music festival experiences for audiences. The purpose of this project was twofold. First, I planned to develop a nuanced human-center
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Schmier, Robert Gordon. "Fade durations in satellite-path mobile radio propagation." Thesis, Virginia Polytechnic Institute and State University, 1986. http://hdl.handle.net/10919/91053.

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Fades on satellite to land mobile radio links are caused by several factors, the most important of which are multipath propagation and vegetative shadowing. Designers of vehicular satellite communications systems require information about the statistics of fade durations in order to overcome or compensate for the fades. Except for a few limiting cases, only the mean fade duration can be determined analytically, and all other statistics must be obtained experimentally or via simulation. This report describes and presents results from a computer program developed at Virginia Tech to simulate s
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LIDÉN, HELEN, and EMELIE GUSTAFSSON. "Fad Fashion : ur ett varumärkesperspektiv." Thesis, Högskolan i Borås, Institutionen Textilhögskolan, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-20129.

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Mardini, Fadi Al. "Etude de l'adsorption du pesticide Bromacil sur charbon actif en poudre en milieu aqueux : effet compétiteur des matières organiques naturelles." Poitiers, 2008. http://theses.edel.univ-poitiers.fr/theses/2008/AlMardini-Fadi/2008-AlMardini-Fadi-These.pdf.

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L’objectif de ce doctorat était de réaliser une étude détaillée des phénomènes d’adsorption du Bromacil (herbicide) sur un charbon actif en poudre, CAP SA-UF, à pH 7,8 et à 20 °C. L’application de plusieurs modèles d’isotherme d’équilibre mono-soluté a globalement montré que l’adsorption du Bromacil se fait sur deux types de sites. Les travaux sur la cinétique d’adsorption ont montré qu’il n’est pas possible de préciser a priori si la diffusion ou la réaction de surface est cinétiquement déterminante. Le modèle de réaction de surface du pseudo-second ordre s’applique particulièrement bien et c
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Chabarek, Fadi Verfasser], and Stefan [Akademischer Betreuer] [Jähnichen. "Interaktive Vervollständigung von Szenariospezifikationen / Fadi Chabarek. Betreuer: Stefan Jähnichen." Berlin : Universitätsbibliothek der Technischen Universität Berlin, 2011. http://d-nb.info/1014946476/34.

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Gremont, Boris Christian. "Fade countermeasure modelling for Ka band digital satellite links." Thesis, Coventry University, 1997. http://curve.coventry.ac.uk/open/items/d85e8a85-635c-d024-3737-d1205f235596/1.

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This thesis investigates the modelling of fade countermeasures (FCMs) for the design of geostationary Ka band digital satellite communication systems. The analysis focuses on a typical low-power low-rate very small aperture terminal application using adaptive forward error correction as a way of counteracting the high level of detected dynamic atmospheric fading. The management and performance of such systems is conditioned greatly by the ability of practical controllers at detecting the actual level of total signal attenuation. At 20 or 30 GHz, rain attenuation and tropospheric scintillation
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Osman, Taha Mohammed. "FADI : a fault-tolerant environment for distributed processing systems." Thesis, Nottingham Trent University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388867.

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Borrero, Brittni M. "Faded Glory: Captain America and the Wilted American Dream." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1334586489.

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Lecomte, Sophie. "Le fard comme médium, objet d'étude et d'expérimentation plastique." Thesis, Aix-Marseille 1, 2011. http://www.theses.fr/2011AIX10065/document.

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Le fard est une composition dont l’application sur la peau donne à celle-ci plus d’éclat ou masque un défaut physique. Accusé de tromper, instrument futile ou diabolique auquel fut comparée la peinture, le fard se définit par sa fonction mais ne s’y réduit pas. L’observation de trois vidéos permet d’étudier le fard en tant qu’il est matière colorée et conduit à déterminer ses propriétés spécifiques et les possibilités plastiques qu’elles véhiculent.Cette recherche vise à établir les modalités d’une relation entre le fard, la couleur, et le corps support au travers d’expériences plastiques film
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Karlström, Fredrik, and Oliwer Granhagen. "When communication starts to fade, everything else (un)follows." Thesis, Högskolan i Halmstad, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-40508.

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Syfte: Syftet med vår studie är att bidra med mer kunskap och en ökad förståelse för relationen mellan influencers och generation Z på Instagram. Vi vill bidra med mer kunskap om generation Z:s uppfattningar av en influencer, trovärdigheten av sponsrade inlägg och hur det påverkar relationen mellan medieanvändare och influencers utifrån ett konsumentperspektiv. Frågeställningar: - Vad utmärker trovärdighet i relationen till influencers enligt generation Z? - Hur bibehåller en influencer sin trovärdighet över tid enligt generation Z? - Hur kan vi förstå vad ett trovärdigt
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Corfield, Wendy Lea. "Conceptualizing complex meaning systems : the case of management fads." Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16535/1/Wendy_Corfield_Thesis.pdf.

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Abstract:
The thesis is an attempt to apply complex systems thinking to the problem of meaning. It is in two parts. Part 1, Chapter 1 introduces the research agenda and overviews the thesis. Chapter 2 establishes the value of adopting a systems approach to the problem of meaning. The next chapter introduces key concepts of complex systems theory as they apply to sociocultural phenomena, and the last chapter in Part 1 reviews three theories of complex meaning systems (Donald Campbell, Jay Lemke, and Paul Cilliers) from which a preliminary model and agenda for theorising complex meaning systems is propos
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46

Corfield, Wendy Lea. "Conceptualizing complex meaning systems : the case of management fads." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16535/.

Full text
Abstract:
The thesis is an attempt to apply complex systems thinking to the problem of meaning. It is in two parts. Part 1, Chapter 1 introduces the research agenda and overviews the thesis. Chapter 2 establishes the value of adopting a systems approach to the problem of meaning. The next chapter introduces key concepts of complex systems theory as they apply to sociocultural phenomena, and the last chapter in Part 1 reviews three theories of complex meaning systems (Donald Campbell, Jay Lemke, and Paul Cilliers) from which a preliminary model and agenda for theorising complex meaning systems is propos
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47

Dias, Danielle Ferreira. "Síntese de potenciais agentes antifúngicos inibidores de glicosamina-6-fosfato síntase." Universidade Federal de Minas Gerais, 2009. http://hdl.handle.net/1843/FARD-82SFMB.

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The aminosugars are very important structural components of bacteria and fungi cell walls. Glucosamine-6-phosphate synthase (GlmS), which catalyses the first step of the aminosugar biosynthetic pathway i.e. the formation of D-glucosamine-6-phosphate from D-fructose-6-phosphate, is therefore an interesting target in the fight against microorganisms. In this work is described the synthesis of aromatics analogs of 2-amino-2-deoxy-D-glucitol-6-phosphate (ADGP) and its epimer 2-amino-2-deoxy-D-manitol-6-phosphate (ADMP) two important inhibitors of GlmS: three phosphoramides and two phosphates; and
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48

Oliveira, Edgard Leite de. "Conflito Social, memória e experiência: a greve dos metalurgicos de Contagem-MG (1968)." Universidade Federal de Minas Gerais, 2010. http://hdl.handle.net/1843/FAED-8DBH4N.

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On April 1968, workers of Contagems industrial district organized the first strike after the Military Coup of 1964 and one of the most significant strikes of Brazilian labor movement. This theme has always been cited in other studies of this particular historical period; however it has never been the central subject of any research. This thesis results from a research that tries to rebuild the event based on documentary sources such as union newsletters, newspapers of left wing organizations involved in that occurrence, printed press and documents found in public archive of Minas Gerais. Howev
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49

Leal, Daniel Henriques Soares. "Macrolactamas derivadas de carboidratos: síntese e análise conformacional por métodos quanto-mecânicos." Universidade Federal de Minas Gerais, 2009. http://hdl.handle.net/1843/FARD-82SFJC.

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In the first chapter of this work, the synthesis of two macrolactams with 11 and 15 members derived from D-galactose is described from the tri-n-butyltin hydride mediated radical cyclization of 2-iodobenzamides and two 3-(iodoacetamido)benzamides. Two macrolactams, resulting from 11- and 15-endo mode ciclization, were isolated, plus the uncyclized reduction products. In the second chapter, it is described the conformational analysis by theoretical calculations with semi-empirical (PM3) and DFT (B3LYP/6-311+G(d,p)) methods for these substracts, which pointed to 11-endo over 10-exo cyclization m
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50

Costa, Andre Lima de Oliveira. "Éster 2-morfolinoetil e sal sódico do ácido micofenólico :: desenvolvimento e validação de métodos analíticos para o controle de qualidade de matéria-prima e comprimidos." Universidade Federal de Minas Gerais, 2009. http://hdl.handle.net/1843/FARD-82TLBV.

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Mycophenolic acid (MPA) is a specific, non-competitive and reversible inhibitor of inosine monophosphate dehydrogenase. It is marketed as pro-drug mycophenolate mofetil (MMF) in immediate release tablets, as well as sodium mycophenolic (MSD) in enteric-coated tablets formulation. The derivatives of MPA are used in the immunosuppression therapy of post-transplant patients. The evaluation of the qualityparameters for drug substance and tablets containing the derivatives of MPA is important to surveillance actions, regulatory matters and to promote national manufacturing by the public official la
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