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Journal articles on the topic 'Failed agent'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Veritti, Daniele, Paolo Lanzetta, Francesco Bandello, and Raffaella Gortana Chiodini. "VISCOELASTIC AGENT RETENTION AND FAILED MACULAR HOLE SURGERY." Retinal Cases & Brief Reports 3, no. 1 (2009): 77–79. http://dx.doi.org/10.1097/icb.0b013e318158de4f.

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Kumar, Anurup. "Capnocytophaga canimorsus Meningitis – Diagnosis with 16S rDNA PCR when Conventional Methods Failed to Identify the Causative Agent." Clinical Research and Clinical Trials 3, no. 4 (2021): 01–06. http://dx.doi.org/10.31579/2693-4779/025.

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Meningitis whether bacterial or viral, poses many challenges to clinicians as the causative agent is often not found. According to guidelines, it is standard to start empiric treatment before a Cerebrospinal Fluid (CSF) sample is obtained. Meningitis, if not diagnosed and treated early, can lead to high morbidity and mortality rates with serious neurological sequelae. While the most common cases of bacterial meningitis are related to Streptococcus pneumoniae and Neisseria meningitidis, this clinical case report found a rare case of meningitis caused by a zoonotic pathogen, Capnocytophaga canim

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3

Agostino, Nicole M., Rebecca Gingrich, and Joseph J. Drabick. "Bevacizumab Demonstrates Prolonged Disease Stabilization in Patients with Heavily Pretreated Metastatic Renal Cell Carcinoma: A Case Series and Review of the Literature." Advances in Urology 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/687043.

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There are now a variety of therapies approved for the treatment of metastatic renal cell carcinoma (RCC). These include the immunotherapeutics, alfa-interferon, and interleukin-2, and agents that target the vascular endothelial growth factor receptor (VEGFR) via its tyrosine kinase, such as sorafenib, sunitinib, and pazopanib, or the mammalian target of rapamycin (mTOR), such as temsirolimus and everolimus. Bevacizumab, a monoclonal antibody directed against the ligand, VEGF, has shown activity against RCC as a single agent in patients who had failed prior cytokine therapy and as first line th

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4

Peacock, David, and Ian Abbott. "The mongoose in Australia: failed introduction of a biological control agent." Australian Journal of Zoology 58, no. 4 (2010): 205. http://dx.doi.org/10.1071/zo10043.

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We reviewed historical literature and obtained nearly 200 records of the mongoose in Australia up to 1942. Although the earliest importations (from 1855) were for its snake-killing prowess, often as entertainment, its perceived potential as a control agent for the European rabbit (Oryctolagus cuniculus) plague saw concerted introductions made in New South Wales, Victoria and South Australia, primarily in 1883 and 1884. At least 1000 mongoose were released to control rabbits at 14 reported release locations in these states. As many as 700 of these mongoose were reported released in one New Sout

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5

Hartline, Jason D. "Approximation in Mechanism Design." American Economic Review 102, no. 3 (2012): 330–36. http://dx.doi.org/10.1257/aer.102.3.330.

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This paper considers three challenge areas for mechanism design and describes the role approximation plays in resolving them. Challenge 1: optimal mechanisms are finely tuned to precise details of the distribution on agent preferences. Challenge 2: in environments with multi-dimensional agent preferences economic analysis has failed to provide general characterizations optimal mechanisms. Challenge 3: optimal mechanisms are parameterized by unrealistic knowledge of the distribution of agents' private preferences. This paper surveys positive resolutions to these challenges with emphasis on basi

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Okun, Ilya, Sergei Malarchuk, Elena Dubrovskaya, et al. "Screening for Caspase-3 Inhibitors: Effect of a Reducing Agent on Identified Hit Chemotypes." Journal of Biomolecular Screening 11, no. 6 (2006): 694–703. http://dx.doi.org/10.1177/1087057106289231.

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When studying cysteinyl proteases in general and caspases in particular, it is generally accepted that a reaction buffer must contain a reducing agent to prevent essential cysteinyl groups from spontaneous oxidation. Dithiothreitol (DTT) and β-mercaptoethanol (β-MCE) are 2 of the most broadly used reducing agents. While screening a library of small molecules against caspase-3, the authors have found that the nature of the reducing agent used, DTT or β-MCE, dramatically affects screening results and leads to identification of nonoverlapping hits. Screening in DTT-containing buffer revealed few

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Honda, Yuko, Taketoshi Furugohri, and Yoshiyuki Morishima. "Tranexamic Acid Failed to Reverse the Anticoagulant Effect and Bleeding by an Oral Direct Factor Xa Inhibitor Edoxaban." Pharmacology 101, no. 1-2 (2017): 92–95. http://dx.doi.org/10.1159/000484172.

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Background/Aims: Agents to reverse the anticoagulant effect of edoxaban, an oral direct factor Xa inhibitor, would be desirable in emergency situations. The aim of this study is to determine the effect of tranexamic acid, an antifibrinolytic agent, on the anticoagulant activity and bleeding by edoxaban in rats. Methods: A supratherapeutic dose of edoxaban (3 mg/kg) was intravenously administered to rats. Three minutes after dosing, tranexamic acid (100 mg/kg) was given intravenously. Bleeding was induced by making an incision with a blade on the planta 8 min after edoxaban injection and bleedi

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Nguyen, Duc Thien, William Yeoh, Hoong Chuin Lau, and Roie Zivan. "Distributed Gibbs: A Linear-Space Sampling-Based DCOP Algorithm." Journal of Artificial Intelligence Research 64 (March 14, 2019): 705–48. http://dx.doi.org/10.1613/jair.1.11400.

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   Researchers have used distributed constraint optimization problems (DCOPs) to model various multi-agent coordination and resource allocation problems. Very recently, Ottens et al. proposed a promising new approach to solve DCOPs that is based on confidence bounds via their Distributed UCT (DUCT) sampling-based algorithm. Unfortunately, its memory requirement per agent is exponential in the number of agents in the problem, which prohibits it from scaling up to large problems. Thus, in this article, we introduce two new sampling-based DCOP algorithms called Sequential Distri

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9

Serudji, Joserizal, Rika Effendy, and Hafni Bachtiar. "PERBEDAAN RERATA KADAR IL-6 SERUM MATERNAL BERDASARKAN KEBERHASILAN PEMBERIAN TOKOLITIK PADA PARTUS PREMATURUS IMMINENS." JOURNAL OBGIN EMAS 1, no. 1 (2019): 15–21. http://dx.doi.org/10.25077/aoj.1.1.15-21.2017.

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Preterm labor needs to be prevented, one of the prevention methods is by tocolytic administration which could prevent labor thus providing a chance for lung maturation. Preterm Pregnancy is associated with increased concentrations of cytokines such as Interleukin (IL). The increasing concentration of maternal serum IL-6 can be used to predict preterm labor. This research uses the design Cross-Sectional Comparative to determine differences in means of maternal serum levels of IL-6 based on the success of the administration of a tocolytic agent on preterm labor. This study was performed on pregn

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Lee, Ha Na, Young-Suk Lee, Ji-Yeon Han, Jae Yong Jeong, Myung-Soo Choo, and Kyu-Sung Lee. "Transurethral injection of bulking agent for treatment of failed mid-urethral sling procedures." International Urogynecology Journal 21, no. 12 (2010): 1479–83. http://dx.doi.org/10.1007/s00192-010-1224-z.

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11

Oliva, Brunello, Keith Miller, Nico Caggiano, et al. "Biological Properties of Novel Antistaphylococcal Quinoline-Indole Agents." Antimicrobial Agents and Chemotherapy 47, no. 2 (2003): 458–66. http://dx.doi.org/10.1128/aac.47.2.458-466.2003.

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ABSTRACT The antibacterial properties of novel quinoline-indole (QI) agents were examined. QI agents demonstrated potent bactericidal activities against Staphylococcus aureus, killing by lytic and nonlytic mechanisms. S. aureus mutants resistant to a lytic QI agent (SEP 155342) and a nonlytic QI agent (SEP 118843) arose at frequencies of 1.4 × 10−9 and 1.2 × 10−8, respectively, by selection at four times the MICs. Mutants resistant to QI agent SEP 155342 were unstable, but mutants resistant to QI agent SEP 118843 displayed stable resistance. Mutants resistant to QI agent SEP 118843 were not cr

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12

Zhu, Jiacheng, Jiahao Lin, Meng Wang, et al. "Generative Adversarial Imitation Learning from Failed Experiences (Student Abstract)." Proceedings of the AAAI Conference on Artificial Intelligence 34, no. 10 (2020): 13997–98. http://dx.doi.org/10.1609/aaai.v34i10.7271.

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Imitation learning provides a family of promising methods that learn policies from expert demonstrations directly. As a model-free and on-line imitation learning method, generative adversarial imitation learning (GAIL) generalizes well to unseen situations and can handle complex problems. In this paper, we propose a novel variant of GAIL called GAIL from failed experiences (GAILFE). GAILFE allows an agent to utilize failed experiences in the training process. Moreover, a constrained optimization objective is formalized in GAILFE to balance learning from given demonstrations and from self-gener

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Leyon, Joe J., Swarupsinh Chavda, Allan Thomas, and Saleh Lamin. "Preliminary experience with the liquid embolic material agent PHIL (Precipitating Hydrophobic Injectable Liquid) in treating cranial and spinal dural arteriovenous fistulas: technical note." Journal of NeuroInterventional Surgery 8, no. 6 (2015): 596–602. http://dx.doi.org/10.1136/neurintsurg-2015-011684.

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BackgroundLiquid embolic agents are the preferred embolic material in endovascular treatment of pial and brain arteriovenous malformations and dural arteriovenous fistulas (DAVFs). There is little choice available in interventional neuroradiology practice other than two of the most commonly used liquid embolic agents—n-butyl cyanoacrylate and the Onyx liquid embolic system (ev3 Neurovascular, Irvine, California, USA). PHIL (Precipitating Hydrophobic Injectable Liquid) (Microvention, Inc California, USA) is a new liquid embolic agent, CE marked and available for clinical use in Europe.Objective

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14

Eng, J., A. Gomez, and S. Mink. "Insensitivity of maximum expiratory flow to bronchodilation in normal dogs." Journal of Applied Physiology 68, no. 5 (1990): 2006–12. http://dx.doi.org/10.1152/jappl.1990.68.5.2006.

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We examined the effects of the inhaled parasympatholytic agent atropine and the sympathomimetic agent salbutamol on partitioned frictional pressure (Pfr) losses to the site of flow limitation (choke point, CP) in dogs to see how changes brought about by these agents would affect maximum expiratory flow (Vmax) and response to breathing 80% He-20% O2 (delta Vmax) in terms of wave-speed theory of flow limitation. In open-chest dogs, a Pitot-static tube was advanced down the right lower lobe to locate CP, to determine CP lateral and end-on pressures (PE), and to partition the airway into periphera

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15

Lumbroso, Darren, Mark Davison, Richard Body, and Gregor Petkovšek. "Modelling the Brumadinho tailings dam failure, the subsequent loss of life and how it could have been reduced." Natural Hazards and Earth System Sciences 21, no. 1 (2021): 21–37. http://dx.doi.org/10.5194/nhess-21-21-2021.

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Abstract. In recent years the number of tailings dams failures has increased. On 25 January 2019, the Brumadinho tailings dam in Brazil suddenly failed, releasing a mudflow over 10 m deep comprising some 107 m3 of mining waste which killed between 270 and 320 people. This paper details the use of an agent-based model, known as the Life Safety Model (LSM), to estimate the risk to people downstream of the Brumadinho tailings dam and to assess if the number of fatalities could have been reduced if a warning had been received prior to or at time the dam failed. The LSM modelling indicates that eve

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16

Saffra, Norman A., and Benjamin J. Reinherz. "Peripapillary Choroidal Neovascularization Associated with Optic Nerve Head Drusen Treated with Anti-VEGF Agents." Case Reports in Ophthalmology 6, no. 1 (2015): 51–55. http://dx.doi.org/10.1159/000375480.

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Optic nerve head drusen can be associated with peripapillary choroidal neovascularization, in both the pediatric and adult population. These membranes can involve the macula, causing significant visual loss. Herein, we present a case that required treatment with an anti-VEGF agent. The patient failed to respond to the initial agent, but subsequently responded to a change of agent. Adult patients with macular degeneration involving peripapillary choroidal neovascularization associated with optic nerve head drusen may require individualized treatment plans.

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17

Marquis, Jean-Philippe, Sonia Goulet, and François Y. Doré. "Schizophrenia-like syndrome inducing agent phencyclidine failed to impair memory for temporal order in rats." Neurobiology of Learning and Memory 80, no. 2 (2003): 158–67. http://dx.doi.org/10.1016/s1074-7427(03)00067-4.

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18

MORI, Takashi, Kazuya NAGATA, Takuo ISHIDA, et al. "FK-506: A New Immunosuppressive Agent, Failed to Reduce Cerebral Vasospasm after Experimental Subarachnoid Hemorrhage." Journal of Veterinary Medical Science 55, no. 4 (1993): 581–86. http://dx.doi.org/10.1292/jvms.55.581.

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19

Ramchurn, S. D., C. Mezzetti, A. Giovannucci, J. A. Rodriguez-Aguilar, R. K. Dash, and N. R. Jennings. "Trust-Based Mechanisms for Robust and Efficient Task Allocation in the Presence of Execution Uncertainty." Journal of Artificial Intelligence Research 35 (June 16, 2009): 119–59. http://dx.doi.org/10.1613/jair.2751.

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Vickrey-Clarke-Groves (VCG) mechanisms are often used to allocate tasks to selfish and rational agents. VCG mechanisms are incentive compatible, direct mechanisms that are efficient (i.e., maximise social utility) and individually rational (i.e., agents prefer to join rather than opt out). However, an important assumption of these mechanisms is that the agents will "always" successfully complete their allocated tasks. Clearly, this assumption is unrealistic in many real-world applications, where agents can, and often do, fail in their endeavours. Moreover, whether an agent is deemed to have fa

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20

Sanna, Alessandro, Antonella Gozzini, Francesca Sassolini, Alberto Bosi, and Valeria Santini. "Decitabine Treatment in Higher Risk MDS, CMML and AML Post-MDS Who Failed Azacitidine." Blood 118, no. 21 (2011): 5052. http://dx.doi.org/10.1182/blood.v118.21.5052.5052.

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Abstract Abstract 5052 Background: 5-azacytidine (Vidaza, AZA) and 5-aza-2'-deoxycytidine (Decitabine, DAC) are active in therapy of myelodysplastic syndromes (MDS) probably with different mechanisms of action. Azacitidine is approved by FDA and EMEA and is routinely used in therapy of higher risk MDS in Europe and in the US. Decitabine is a demethylating agent approved for treatment of IPSS INT-2 and high risk MDS by FDA but not yet from EMEA and it seems particularly active in Chronic myelomonocytic leukemia (CMML) and AML of the elderly. Difference in mechanisms of action of these 2 agents

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21

Sadilek, A., and H. Kautz. "Location-Based Reasoning about Complex Multi-Agent Behavior." Journal of Artificial Intelligence Research 43 (January 31, 2012): 87–133. http://dx.doi.org/10.1613/jair.3421.

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Recent research has shown that surprisingly rich models of human activity can be learned from GPS (positional) data. However, most effort to date has concentrated on modeling single individuals or statistical properties of groups of people. Moreover, prior work focused solely on modeling actual successful executions (and not failed or attempted executions) of the activities of interest. We, in contrast, take on the task of understanding human interactions, attempted interactions, and intentions from noisy sensor data in a fully relational multi-agent setting. We use a real-world game of captur

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Burnakis, Thomas G. "Inaccurate Assessment of Drug-Induced Thrombocytopenia: Reason for Concern." Annals of Pharmacotherapy 28, no. 6 (1994): 726–29. http://dx.doi.org/10.1177/106002809402800608.

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OBJECTIVE: To report two cases in which patients were reputed to have exhibited thrombocytopenia secondary to the histamine-receptor blocking agent ranitidine. Evaluation and the associated time frame of events failed to confirm these observations. DESIGN: Two case studies. RESULTS: Ranitidine was ordered as part of the therapeutic course of two patients admitted to the medicine service. The development of thrombocytopenia in both patients was attributed to this agent and it was discontinued. In addition to ranitidine, both patients received several other agents with greater potential to cause

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Dada, Reyad, and Fawwaz Yassin. "Everolimus Is Active in Pretreated Hodgkin Lymphoma after Failure of Brentuximab Vedotin: Single Institute Experience." Blood 128, no. 22 (2016): 5368. http://dx.doi.org/10.1182/blood.v128.22.5368.5368.

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Abstract Introduction: Patients with Hodgkin lymphoma (HL) relapsing after ASCT and those not eligible for myeloablative therapy can be salvaged with conventional chemotherapy or new novel agents such the immunotoxin brentuximab vedotin and the recently FDA approved anti-PD-1 inhibitor nivolumab. Other options include the mTOR inhibitor everolimus (1) for which, the data in literature is scarce. Moreover, there is no data on the efficacy of everolimus after failure of brentuximab vedotin. Patients and methods: In this study, we retrospectively analyzed the outcome of patients with relapsed/ re

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Moore, T. D., P. H. Phillips, S. R. Nerenstone, and B. D. Cheson. "Systemic treatment of advanced and recurrent endometrial carcinoma: current status and future directions." Journal of Clinical Oncology 9, no. 6 (1991): 1071–88. http://dx.doi.org/10.1200/jco.1991.9.6.1071.

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Multiple systemic therapies have been used to treat patients with endometrial cancer. Although progestins have been the standard initial treatment for metastatic disease for the past 30 years, they are effective in only 20% of patients, and several large randomized trials have failed to demonstrate any benefit in the adjuvant setting. Alternative agents such as tamoxifen have shown modest activity. Few studies have investigated combinations of hormonally active drugs. Doxorubicin and cisplatin are the most active cytotoxic agents; a current randomized study is comparing the combination of thes

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Popugaeva, Elena. "Fine Tuning of Intracellular Ca2+ Content by Pharmacological Agents – A Strategy to Prevent Synapse Loss in Alzheimer Disease Hippocampal Neurons." Current Alzheimer Research 17, no. 12 (2021): 1065–71. http://dx.doi.org/10.2174/1567205018666210119145735.

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: Alzheimer disease is the dominant form of elderly dementia. Today all clinical trials that target β-amyloid have failed to indicate that β-amyloid may not be a causative agent in AD pathogenesis. Thus there is a need to search for alternative ways to treat AD patients. : Neuronal store-operated calcium entry is a fine-tuning mechanism that regulates intracellular Ca2+ content. Recent evidence suggests that store-operated calcium channels may be targeted with pharmacological agents in order to prevent synapse loss, recover long-term potentiation and change behavior. : Current mini-review disc

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Gregorini, Luisa, Jean Marco, Monique Bernies, et al. "The Alpha-1 Adrenergic Blocking Agent Urapidil Counteracts Postrotational Atherectomy “Elastic Recoil” Where Nitrates Have Failed." American Journal of Cardiology 79, no. 8 (1997): 1100–1103. http://dx.doi.org/10.1016/s0002-9149(97)00053-2.

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Pellegrin, F., N. Duran-Vila, M. Van Munster, and D. Nandris. "Rubber tree (Hevea brasiliensis) trunk phloem necrosis: aetiological investigations failed to confirm any biotic causal agent." Forest Pathology 37, no. 1 (2007): 9–21. http://dx.doi.org/10.1111/j.1439-0329.2007.00471.x.

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28

AlDhaheri, Fahmi, Talal Almteri, Naji Dwid, Ahd Majdali, Nahed Janoudi та Hani Almoallim. "Rituximab Can Induce Remission in a Patient with Ankylosing Spondylitis Who Failed Anti-TNF-α Agent". American Journal of Case Reports 18 (9 лютого 2017): 143–47. http://dx.doi.org/10.12659/ajcr.900563.

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Lee, Sung-Eun, Jae-Ho Yoon, Seung-Hwan Shin, et al. "Impact of failed response to novel agent induction in autologous stem cell transplantation for multiple myeloma." Annals of Hematology 93, no. 4 (2013): 627–34. http://dx.doi.org/10.1007/s00277-013-1911-1.

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Nabhan, Chadi, and Neil E. Kay. "The Emerging Role of Ofatumumab in the Treatment of Chronic Lymphocytic Leukemia." Clinical Medicine Insights: Oncology 5 (January 2011): CMO.S4087. http://dx.doi.org/10.4137/cmo.s4087.

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The treatment of chronic lymphocytic leukemia (CLL) has evolved over the past decade. Our better understanding of disease biology and risk stratification has allowed delivering more effective therapies. In fact, front-line chemoimmunotherapy has demonstrated improvement in overall survival when compared to chemotherapy in randomized studies. Yet, treatment of relapsed CLL remains challenging and few agents are effective in that setting. Ofatumumab (Ofa) is a humanized monoclonal antibody targeted against CD20 with demonstrable activity in rituximab-resistant CLL cell lines. This agent was rece

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Loraine, Jessica, Feifei Pu, Obolbek Turapov, and Galina V. Mukamolova. "Development of anIn VitroAssay for Detection of Drug-Induced Resuscitation-Promoting-Factor-Dependent Mycobacteria." Antimicrobial Agents and Chemotherapy 60, no. 10 (2016): 6227–33. http://dx.doi.org/10.1128/aac.00518-16.

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ABSTRACTTuberculosis is a major infectious disease that requires prolonged chemotherapy with a combination of four drugs. Here we present data suggesting that treatment ofMycobacterium tuberculosis, the causative agent of tuberculosis, andMycobacterium smegmatis, a model organism widely used for the screening of antituberculosis agents, with first-line drugs resulted in the generation of substantial populations that could be recovered only by the addition of a culture supernatant from growing mycobacteria. These bacilli failed to grow in standard media, resulting in significant underestimation

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Marik, Paul. "Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid." Nutrients 10, no. 11 (2018): 1762. http://dx.doi.org/10.3390/nu10111762.

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Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid and Thiamine (HAT therapy) may reduce organ failure and mortality in patients with sepsis and septic shock. HAT therapy is based on the concept that a combination of readily available, safe and cheap agents, which target multiple components of the host’s response to an infectious agent,

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Riganti, Chiara, Roberta Giampietro, Joanna Kopecka, et al. "MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor." International Journal of Molecular Sciences 21, no. 9 (2020): 3333. http://dx.doi.org/10.3390/ijms21093333.

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Multidrug resistance (MDR) is the main obstacle to current chemotherapy and it is mainly due to the overexpression of some efflux transporters such as MRP1. One of the most studied strategies to overcome MDR has been the inhibition of MDR pumps through small molecules, but its translation into the clinic unfortunately failed. Recently, a phenomenon called collateral sensitivity (CS) emerged as a new strategy to hamper MDR acting as a synthetic lethality, where the genetic changes developed upon the acquisition of resistance towards a specific agent are followed by the development of hypersensi

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Liu, G., M. Crump, P. E. Goss, J. Dancey, and F. A. Shepherd. "Prospective comparison of the sclerosing agents doxycycline and bleomycin for the primary management of malignant pericardial effusion and cardiac tamponade." Journal of Clinical Oncology 14, no. 12 (1996): 3141–47. http://dx.doi.org/10.1200/jco.1996.14.12.3141.

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PURPOSE To compare the clinical efficacy and toxicity of doxycycline and bleomycin as sclerosing agents in the primary management of malignant pericardial effusion (MPE). METHODS Twenty-seven consecutive adult patients referred to a tertiary-care institution for the management of cardiac tamponade and malignancy underwent pericardial drainage through a percutaneously placed pigtail catheter. They were then alternately assigned to undergo bleomycin or doxycycline pericardial sclerosis. RESULTS There were 13 men and 14 women, with a median age of 59 years. They mainly had lung (70%) and breast c

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Newaz, Mohammad Tanvi, Peter Rex Davis, Marcus Jefferies, and Manikam Pillay. "Validation of an agent-specific safety climate model for construction." Engineering, Construction and Architectural Management 26, no. 3 (2019): 462–78. http://dx.doi.org/10.1108/ecam-01-2018-0003.

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Purpose Safety climate (SC) is considered a leading indicator of safety performance, but scholars suggest that a common SC assessment framework is yet to be developed. Following the debate between the importance of facet analysis and agent analysis, the purpose of this paper is to test a factor structure, developed by the authors in previous work and arising from their systematic literature review, highlighting the role of safety agents in a construction site setting. Design/methodology/approach Multi-level SC surveys were conducted at five construction sites in Sydney, Australia, collecting d

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Nieva, Jorge, Kelly Bethel, and Alan Saven. "Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia." Blood 102, no. 3 (2003): 810–13. http://dx.doi.org/10.1182/blood-2003-01-0014.

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Abstract Hairy cell leukemia (HCL) is an indolent B-cell neoplasm, strongly expressing CD20. Despite initial very high response rates following cladribine, many patients (pts) ultimately relapse. Having relapsed after prior treatment with cladribine, 24 HCL pts (21 male, 3 female) with a median age of 53.5 years were treated with rituximab at 375 mg/m2 intravenously weekly for 4 weeks. Of the pts, 3 (13%) achieved complete remissions and 3 (13%), partial responses. Thus, 6 (25%) of 24 pts achieved a response following rituximab. At a median follow-up of 14.6 months, 2 responders have relapsed;

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Das, Satya, and Michael K. Gibson. "Evolving Management Strategies for Metastatic Esophageal and Gastroesophageal Junction Adenocarcinoma." Oncology & Hematology Review (US) 14, no. 2 (2018): 82. http://dx.doi.org/10.17925/ohr.2018.14.2.82.

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Metastatic or unresectable esophageal and gastroesophageal junction adenocarcinoma represent a devastating disease with 5-year survival rate of <5%. Although cytotoxic chemotherapy with platinum doublet based regimens is initially effective, patients inevitably progress. Patients often decline rapidly after this initial progression, making later lines of therapy a challenge to successfully administer. There have been multiple efforts to incorporate biologic agents, targeting pathways known to be dysregulated in esophageal adenocarcinoma and gastroesophageal junction adenocarcinoma, into exi

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Zhamanova, Amina A. "Dream Collaborations: From the History of Eugene O’Neill’s Failed Projects." Literature of the Americas, no. 10 (2021): 25–45. http://dx.doi.org/10.22455/2541-7894-2021-10-25-45.

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This article is focused on Eugene O’Neill’s failed artistic collaborations with outstanding directors, actors and singers. It is the first attempt, in the Russian theatre studies, to get to the truth behind the playwright’s unrealized tandem with the legendary opera singer Feodor Chaliapin. The creative destiny of O’Neill’s play Lazarus Laughed (1927) is tracked from the attempts to stage it in New York, Chicago, Berlin and Moscow, all the way to the long-anticipated premiere at the Pasadena Playhouse in Pasadena, California. Special attention is paid to the Kamerny Theatre shows in Paris and

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Hotta, Katsuyuki, Keitaro Matsuo, Hiroshi Ueoka, Katsuyuki Kiura, Masahiro Tabata, and Mitsune Tanimoto. "Meta-Analysis of Randomized Clinical Trials Comparing Cisplatin to Carboplatin in Patients With Advanced Non–Small-Cell Lung Cancer." Journal of Clinical Oncology 22, no. 19 (2004): 3852–59. http://dx.doi.org/10.1200/jco.2004.02.109.

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Purpose It remains undetermined whether cisplatin and carboplatin are equally effective for advanced non–small-cell lung cancer (NSCLC). We therefore did a meta-analysis of trials that compared cisplatin-based chemotherapy with carboplatin-based chemotherapy. Methods We performed a literature search to identify trials that had investigated the substitution of carboplatin for cisplatin in the treatment of advanced NSCLC. We evaluated these trials for inclusion, rated methodologic quality, and abstracted relevant data. Results Of 1,191 reports, eight trials (2,948 patients) were identified, five

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English, Brett A., Daniel J. Still, John Harper, and Steven R. Saklad. "Failure of Tolterodine to Treat Clozapine-Induced Nocturnal Enuresis." Annals of Pharmacotherapy 35, no. 7-8 (2001): 867–69. http://dx.doi.org/10.1345/aph.10304.

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OBJECTIVE: To report the use and subsequent failure of the bladder-selective agent tolterodine, to treat clozapine-induced nocturnal enuresis in an adolescent patient with psychotic illness. CASE SUMMARY: A 16-year-old Hispanic girl was admitted to the state psychiatric hospital with a diagnosis of bipolar disorder with psychotic features. Clozapine therapy was initiated, and after three months of treatment the patient began experiencing episodes of nocturnal enuresis. The bladder-selective agent tolterodine was tried and subsequently failed to resolve the enuresis episodes. Desmopressin was i

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Dessler, David. "What's at stake in the agent-structure debate?" International Organization 43, no. 3 (1989): 441–73. http://dx.doi.org/10.1017/s0020818300032999.

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Recent developments in the philosophy of science, particularly those falling under the rubric of “scientific realism,” have earned growing recognition among theorists of international relations but have failed to generate substantive programs of research. Consequently, the empirical relevance of much philosophical discourse, such as that centering on the agent-structure problem in social theory, remains unestablished. This article attempts to bridge the gap between the philosophy and practice of science by outlining a model of international structure based on the principles of scientific reali

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Townsley, Danielle M., and Thomas Winkler. "Nontransplant therapy for bone marrow failure." Hematology 2016, no. 1 (2016): 83–89. http://dx.doi.org/10.1182/asheducation-2016.1.83.

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Abstract Nontransplant therapeutic options for acquired and constitutional aplastic anemia have significantly expanded during the last 5 years. In the future, transplant may be required less frequently. That trilineage hematologic responses could be achieved with the single agent eltrombopag in refractory aplastic anemia promotes new interest in growth factors after years of failed trials using other growth factor agents. Preliminary results adding eltrombopag to immunosuppressive therapy are promising, but long-term follow-up data evaluating clonal evolution rates are required before promotin

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Chen, Can, Wenwei Zuo, Pan Yang, and Yanling Zhang. "Anti-PD-1, anti-VEGF, and temozolomide therapy in a patient with recurrent glioblastoma: a case report." Journal of International Medical Research 48, no. 9 (2020): 030006052095139. http://dx.doi.org/10.1177/0300060520951395.

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Background Patients suffering from postoperative recurrent glioblastoma have an extremely unfavorable outcome because there are no proven therapeutic options. The median overall survival for those with relapsed glioblastoma after surgery is only 7.5 months. Case presentation: Between March 2015 and October 2019, a 44-year-old female patient with recurrent glioblastoma was treated by our medical team. After several failed rounds of therapy, the patient was subsequently treated with the anti-programmed death (PD)-1 antibody nivolumab, anti-vascular endothelial growth factor (VEGF) antibody bevac

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Friend, Keith E. "Acromegaly: A New Therapy." Cancer Control 9, no. 3 (2002): 232–35. http://dx.doi.org/10.1177/107327480200900306.

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Background The treatment of acromegaly can be challenging. Despite a multimodality approach (surgery, radiation, dopamine agonists, somatostatin analogs), many patients do not achieve normalization of serum insulin-like growth factor I (IGF-I) concentrations. Methods The author discusses the characteristics and indications of pegvisomant therapy for patients with acromegaly and compares the use of this newly developed GH receptor antagonist with other pharmacological agents such as somatostatin and dopamine agonists. Results Therapy with pegvisomant allows serum IGF-I concentrations to be norm

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Si, Mei. "Should I Stop Thinking About It: A Computational Exploration of Reappraisal Based Emotion Regulation." Advances in Human-Computer Interaction 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/856726.

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Agent-based simulation of people’s behaviors and minds has become increasingly popular in recent years. It provides a research platform to simulate and compare alternative psychological and social theories, as well as to create virtual characters that can interact with people or among each other to provide pedagogical or entertainment effects. In this paper, we investigate computationally modeling people’s coping behaviors and in particular in relation to depression, in decision-theoretic agents. Recent studies have suggested that depression can result from failed emotion regulation under limi

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Mukhopadhyay, Srirupa, Sandip Bhattacharyya, Ramdhan Majhi, et al. "Use of an Attenuated Leishmanial Parasite as an Immunoprophylactic and Immunotherapeutic Agent against Murine Visceral Leishmaniasis." Clinical Diagnostic Laboratory Immunology 7, no. 2 (2000): 233–40. http://dx.doi.org/10.1128/cdli.7.2.233-240.2000.

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ABSTRACT The ability of the leishmanial parasite UR6 to act as an immunoprophylactic and immunotherapeutic agent against Leishmania donovani infection in BALB/c mice was investigated. Unlike the virulent L. donovani AG83 (MOHOM/IN/1983/AG83), UR6 given through intracardiac route failed to induce visceral infection, but when it was injected subcutaneously, UR6 induced a short-lived and localized self-healing skin lesion. Priming of peritoneal macrophages with UR6 in vitro induced superoxide (O2 −) generation, whereas similar experiments with virulent AG83 inhibited O2 − generation. It was obser

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BLOM, MARLIES, WIETSKE KIEVIT, JAAP FRANSEN, et al. "The Reason for Discontinuation of the First Tumor Necrosis Factor (TNF) Blocking Agent Does Not Influence the Effect of a Second TNF Blocking Agent in Patients with Rheumatoid Arthritis." Journal of Rheumatology 36, no. 10 (2009): 2171–77. http://dx.doi.org/10.3899/jrheum.090054.

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Objective.To investigate whether the reason for discontinuation of the first tumor necrosis factor (TNF) blocking agent influences the effect of a second TNF blocking agent.Methods.Data were used from 2 Dutch registries including patients with rheumatoid arthritis (RA) treated with TNF blocking agents. Patients were divided into 3 groups based on reason for discontinuation of the first: nonresponse, loss of response, or adverse events. The primary outcome was the change from baseline of the disease activity (by DAS28) at 6 months, corrected for the baseline DAS28 score. Secondary outcomes were

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Surian, Luca, Stefania Caldi, and Dan Sperber. "Attribution of Beliefs by 13-Month-Old Infants." Psychological Science 18, no. 7 (2007): 580–86. http://dx.doi.org/10.1111/j.1467-9280.2007.01943.x.

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In two experiments, we investigated whether 13-month-old infants expect agents to behave in a way that is consistent with information to which they have been exposed. Infants watched animations in which an animal was either provided information or prevented from gathering information about the actual location of an object. The animal then searched successfully or failed to retrieve the object. Infants' looking times suggest that they expected searches to be effective when—and only when—the agent had had access to the relevant information. This result supports the view that infants possess an i

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Freeman, Hugh J., Jennifer E. Davis, Marcia E. Prest, and Edward J. Lawson. "Granulomatous Bronchiolitis with Necrobiotic Pulmonary Nodules in Chrohn's Disease." Canadian Journal of Gastroenterology 18, no. 11 (2004): 687–90. http://dx.doi.org/10.1155/2004/729689.

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A 37-year-old man with extensive Crohn's disease of the stomach, small and large intestine for almost a decade developed respiratory symptoms and radiological findings suggestive of pneumonia that failed to resolve with antibiotic treatment. Computed tomography scanning of his lungs showed extensive changes with cavitated parenchymal nodules. Histological evaluation of an open lung biopsy showed granulomatous bronchiolitis and pulmonary necrobiosis. Treatment with steroids and immunosuppression resulted in complete resolution of his clinical symptoms of pneumonia and abnormal computed tomograp

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Menna, Cecilia, Claudio Andreetti, Mohsen Ibrahim, et al. "The Effect of Silver Nitrate Pleurodesis after a Failed Thoracoscopic Talc Poudrage." BioMed Research International 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/295890.

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Background. Chemical pleurodesis is the procedure of choice in the management of recurrent malignant pleural effusions (MPE). Talc is probably the most effective sclerosant, with a success rate of 80%. The aim of this study is to demonstrate the effectiveness of silver nitrate solution (SNS) pleurodesis after an unsuccessful thoracoscopic talc poudrage.Methods. Between 2011 and 2013 one hundred and nine patients with unilateral MPE underwent thoracoscopic talc poudrage. Seventeen patients who did not obtain a successful pleurodesis via thoracoscopic procedure were considered for an SNS slurry.

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