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Journal articles on the topic 'Failsafe mechanism'

Author: Grafiati

Published: 28 June 2021

Last updated: 29 July 2025

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1

Dong, Ke, Quan Quan, and W. Murray Wonham. "Failsafe Mechanism Design for Autonomous Aerial Refueling using State Tree Structures." Unmanned Systems 07, no. 04 (2019): 261–79. http://dx.doi.org/10.1142/s2301385019500109.

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Autonomous Aerial Refueling (AAR) is vulnerable to various failures and involves cooperation among autonomous receivers, tankers and remote pilots. Dangerous flight maneuvers may be executed when unexpected failures or command conflicts happen. To solve this problem, a failsafe mechanism based on State Tree Structures (STS) is proposed. The failsafe mechanism is a control logic that guides what subsequent actions the autonomous receiver should take, by observing real-time information of internal low-level subsystems such as guidance and drogue&probe and external instructions from tankers a

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2

Lockwood, Nicola, Silvia Martini, Ainara Lopez-Pardo, et al. "Genome-Protective Topoisomerase 2a-Dependent G2 Arrest Requires p53 in hTERT-Positive Cancer Cells." Cancer Research 82, no. 9 (2022): 1762–73. http://dx.doi.org/10.1158/0008-5472.can-21-1785.

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Abstract Topoisomerase 2a (Topo2a)-dependent G2 arrest engenders faithful segregation of sister chromatids, yet in certain tumor cell lines where this arrest is dysfunctional, a PKCε-dependent failsafe pathway can be triggered. Here we elaborate on recent advances in understanding the underlying mechanisms associated with this G2 arrest by determining that p53–p21 signaling is essential for efficient arrest in cell lines, in patient-derived cells, and in colorectal cancer organoids. Regulation of this p53 axis required the SMC5/6 complex, which is distinct from the p53 pathways observed in the

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3

Quan, Quan, Zhiyao Zhao, Liyong Lin, Peng Wang, Walter Murray Wonham, and Kai-Yuan Cai. "Failsafe mechanism design of multicopters based on supervisory control theory." IET Cyber-Systems and Robotics 2, no. 1 (2020): 31–42. http://dx.doi.org/10.1049/iet-csr.2019.0039.

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4

Sheyko, Yaroslav, Nataliia Kryvko, and Oleksandr Shefer. "Enhancement Arduplane Radio Failsafe Algorithm by Extending with a New Delegation Action." Electronics and Control Systems 1, no. 83 (2025): 42–49. https://doi.org/10.18372/1990-5548.83.19873.

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The article deals with the problem of the absence of a radio failsafe mechanism in the unmanned aerial vehicles' ArduPilot firmware that delegates the flight control management from manual mode to the onboard companion computer once the radio transmitter signal is lost due to natural reasons or caused by military-grade artificial radio interference. Algorithms for detecting signal loss and switching control to onboard computers are proposed. The proposed algorithms require knowledge adjustments and enhancements in three components: MAVlink protocol as a transport between parties, ArduPilot fir

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Irham Fadilah and Endah Fitriani. "Rancang Bangun Protokol Alternatif Saat Konektivitas Internet Terputus Pada Pertanian Berbasis IoT." Jupiter: Publikasi Ilmu Keteknikan Industri, Teknik Elektro dan Informatika 3, no. 1 (2025): 205–12. https://doi.org/10.61132/jupiter.v3i1.705.

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In the era of agricultural digitalization, dependence on Internet of Things (IoT) technology is increasing, yet supporting infrastructure remains vulnerable to connectivity disruptions. This research aims to develop an alternative protocol for IoT-based agricultural systems that can operate during internet connection failures, focusing on implementing a failsafe mode using NodeMCU ESP8266. The research methodology includes developing a monitoring system using soil moisture sensors and ultrasonic sensors for water level detection, as well as performance evaluation based on decision-making accur

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Nagel, Felix, Anne Susemihl, Norman Geist, et al. "Structural Basis of the Pancreatitis-Associated Autoproteolytic Failsafe Mechanism in Human Anionic Trypsin." Journal of Inflammation Research Volume 15 (June 2022): 3633–42. http://dx.doi.org/10.2147/jir.s367699.

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Braglia, Priscilla, Junya Kawauchi, and Nick J. Proudfoot. "Co-transcriptional RNA cleavage provides a failsafe termination mechanism for yeast RNA polymerase I." Nucleic Acids Research 39, no. 4 (2010): 1439–48. http://dx.doi.org/10.1093/nar/gkq894.

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8

Yip, Hon Yan K., Annabel Chee, Ching-Seng Ang, et al. "Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression." Molecular Cell 80, no. 2 (2020): 279–95. http://dx.doi.org/10.1016/j.molcel.2020.09.027.

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Blume, Karin E., Szabolcs Soeroes, Michaela Waibel, et al. "Cell Surface Externalization of Annexin A1 as a Failsafe Mechanism Preventing Inflammatory Responses during Secondary Necrosis." Journal of Immunology 183, no. 12 (2009): 8138–47. http://dx.doi.org/10.4049/jimmunol.0902250.

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10

Casilag, Fiordiligie, Anne Lorenz, Jonas Krueger, Frank Klawonn, Siegfried Weiss, and Susanne Häussler. "The LasB Elastase of Pseudomonas aeruginosa Acts in Concert with Alkaline Protease AprA To Prevent Flagellin-Mediated Immune Recognition." Infection and Immunity 84, no. 1 (2015): 162–71. http://dx.doi.org/10.1128/iai.00939-15.

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The opportunistic pathogenPseudomonas aeruginosais capable of establishing severe and persistent infections in various eukaryotic hosts. It encodes a wide array of virulence factors and employs several strategies to evade immune detection. In the present study, we screened the Harvard Medical School transposon mutant library ofP. aeruginosaPA14 for bacterial factors that modulate interleukin-8 responses in A549 human airway epithelial cells. We found that in addition to the previously identified alkaline protease AprA, the elastase LasB is capable of degrading exogenous flagellin under calcium

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11

Kotula, Leszek, Anita Hryniewicz-Jankowska, Xiang Li, et al. "Correlation of ABI1 and PTEN expression during prostate tumor progression." Journal of Clinical Oncology 40, no. 6_suppl (2022): 172. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.172.

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172 Background: Mechanisms of tumor invasion are not well defined. PTEN, a key tumor suppressor frequently inactivated in epithelial cancers, acts as a central node that controls tumor invasion. Despite PI-3 kinase-phospho-Akt pathway activation resulting in enhanced tumor growth, prostate tumors with PTEN loss undergo p53-mediated senescence that restricts tumor invasion. Methods: ABI1 downregulation is associated with epithelial-mesenchymal transition in highly invasive prostate tumors; these tumors frequently loose PTEN; therefore we set to examine genetic interaction of ABI1 and PTEN using

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Ramaswamy, Mithilesh. "Cognitive Companion AI for Vulnerable Demographics: Fraud Prevention and Real-Time Protection for the Elderly." International Scientific Journal of Engineering and Management 03, no. 12 (2024): 1–6. https://doi.org/10.55041/isjem02132.

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Online fraud is a growing threat, particularly for demographics such as the elderly, who are more susceptible to manipulative tactics and phishing attempts. This paper introduces "Cognitive Companion AI," a novel Agentic AI system designed to provide real-time fraud prevention and education for vulnerable users. Leveraging advanced natural language processing (NLP), emotion-aware analytics, contextual threat recognition, and human-in-the-loop monitoring, the Cognitive Companion analyzes online interactions for fraudulent indicators and provides live alerts with actionable explanations. The fra

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13

Wang, Honghai, Fujun Wen, Guiqian Liu, et al. "An All-Electric Gate Valve Actuator for Subsea Production Control Systems, Part A: Prototype and Test." Journal of Marine Science and Engineering 11, no. 5 (2023): 1043. http://dx.doi.org/10.3390/jmse11051043.

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To bridge the gap that exists in the key equipment of the new subsea production control system, the all-electric subsea gate valve actuator, and exploit subsea oil and gas resources with high reliability and safety while saving energy, this paper proposes a novel concept prototype of an all-electric subsea gate valve actuator which has the key functions of a redundant drive, failsafe closing, auxiliary override, position indication, and low-power position holding. It satisfied the electrically-driven requirements of the subsea gate valves and achieved Safety Integrity Level 3. The prototype wa

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14

Lin, Jer-Young, Brandon H. Le, Min Chen, et al. "Similarity between soybean and Arabidopsis seed methylomes and loss of non-CG methylation does not affect seed development." Proceedings of the National Academy of Sciences 114, no. 45 (2017): E9730—E9739. http://dx.doi.org/10.1073/pnas.1716758114.

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We profiled soybean and Arabidopsis methylomes from the globular stage through dormancy and germination to understand the role of methylation in seed formation. CHH methylation increases significantly during development throughout the entire seed, targets primarily transposable elements (TEs), is maintained during endoreduplication, and drops precipitously within the germinating seedling. By contrast, no significant global changes in CG- and CHG-context methylation occur during the same developmental period. An Arabidopsis ddcc mutant lacking CHH and CHG methylation does not affect seed develo

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Liu, Haiyan, Judith A. Enyeart, and John J. Enyeart. "ACTH Inhibits bTREK-1 K+ Channels through Multiple cAMP-dependent Signaling Pathways." Journal of General Physiology 132, no. 2 (2008): 279–94. http://dx.doi.org/10.1085/jgp.200810003.

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Bovine adrenal zona fasciculata (AZF) cells express bTREK-1 K+ channels that set the resting membrane potential and function pivotally in the physiology of cortisol secretion. Inhibition of these K+ channels by adrenocorticotropic hormone (ACTH) or cAMP is coupled to depolarization and Ca2+ entry. The mechanism of ACTH and cAMP-mediated inhibition of bTREK-1 was explored in whole cell patch clamp recordings from AZF cells. Inhibition of bTREK-1 by ACTH and forskolin was not affected by the addition of both H-89 and PKI(6–22) amide to the pipette solution at concentrations that completely block

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Wu, Yen-Chi, Geetanjali Chawla, and Nicholas Sokol. "let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State." G3: Genes|Genomes|Genetics 10, no. 4 (2020): 1393–401. http://dx.doi.org/10.1534/g3.120.401042.

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During Drosophila melanogaster metamorphosis, arrested immature neurons born during larval development differentiate into their functional adult form. This differentiation coincides with the downregulation of two zinc-finger transcription factors, Chronologically Inappropriate Morphogenesis (Chinmo) and the Z3 isoform of Broad (Br-Z3). Here, we show that br-Z3 is regulated by two microRNAs, let-7 and miR-125, that are activated at the larval-to-pupal transition and are known to also regulate chinmo. The br-Z3 3′UTR contains functional binding sites for both let-7 and miR-125 that confers sensi

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17

Ullah, Zahid, Thachapan Sermsrisuwan, Khemwutta Pornpipatsakul, Ronnapee Chaichaowarat, and Witaya Wannasuphoprasit. "High-Transparency Linear Actuator Using an Electromagnetic Brake for Damping Modulation in Physical Human–Robot Interaction." Journal of Sensor and Actuator Networks 13, no. 5 (2024): 65. http://dx.doi.org/10.3390/jsan13050065.

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Enhancing the transparency of high-transmission-ratio linear actuators is crucial for improving the safety and capability of high-force robotic systems having physical contact with humans in unstructured environments. However, realizing such enhancement is challenging. A proposed solution for active body weight support systems involves employing a macro–mini linear actuator incorporating an electrorheological-fluid brake to connect a high-force unit with an agile, highly back-drivable unit. This paper introduces the use of an electromagnetic (EM) brake with reduced rotor inertia to address thi

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18

Perez, Amilcar J., Yann Cesbron, Sidney L. Shaw, et al. "Movement dynamics of divisome proteins and PBP2x:FtsW in cells of Streptococcus pneumoniae." Proceedings of the National Academy of Sciences 116, no. 8 (2019): 3211–20. http://dx.doi.org/10.1073/pnas.1816018116.

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Bacterial cell division and peptidoglycan (PG) synthesis are orchestrated by the coordinated dynamic movement of essential protein complexes. Recent studies show that bidirectional treadmilling of FtsZ filaments/bundles is tightly coupled to and limiting for both septal PG synthesis and septum closure in some bacteria, but not in others. Here we report the dynamics of FtsZ movement leading to septal and equatorial ring formation in the ovoid-shaped pathogen, Streptococcus pneumoniae. Conventional and single-molecule total internal reflection fluorescence microscopy (TIRFm) showed that nascent

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19

Arjes, Heidi A., Allison Kriel, Nohemy A. Sorto, Jared T. Shaw, Jue D. Wang, and Petra Anne Levin. "Failsafe Mechanisms Couple Division and DNA Replication in Bacteria." Current Biology 24, no. 18 (2014): 2149–55. http://dx.doi.org/10.1016/j.cub.2014.07.055.

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20

Singh, Abhay, and Sanjeevi Shanthakumar. "Economic and Legal Impact of 2020 Sulphur Limit Under Annex VI, MARPOL." European Energy and Environmental Law Review 31, Issue 4 (2022): 241–57. http://dx.doi.org/10.54648/eelr2022017.

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Effective from 1 January 2020, the International Maritime Organisation (IMO) has brought down the permissible sulphur emission from vessels to 0.50% m/m from the earlier set 3.5% m/m Sulphur emission limit. The maritime stakeholders stepping away from Heavy Sulphur Fuel Oil (HSFO) and looking towards Very Low Sulphur Fuel Oil, Liquefied Natural Gas, Marine Gas Oil, (VLSFO, LNG, MGO), for compliance or use of Exhaust Gas Cleaning Systems (EGCS) with HSFO. These modes of compliance however are not completely failsafe as they present economical and regulatory challenges. The article presents a st

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21

Thomas, Kenneth R. "Professional Credentialing: A Doomsday Machine Without a Failsafe." Journal of Applied Rehabilitation Counseling 24, no. 4 (1993): 74–76. http://dx.doi.org/10.1891/0047-2220.24.4.74.

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22

Lehners, Nicola, Elena Ellert, Jing Xu, Hartmut Goldschmidt, Mindaugas Andrulis, and Marc S. Raab. "Oncogene Induced Senescence As a Potential Breakpoint Mechanism Against Malignant Transformation in Plasma Cell Disorders." Blood 128, no. 22 (2016): 4474. http://dx.doi.org/10.1182/blood.v128.22.4474.4474.

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Abstract Background: Cellular senescence has been recognized as a failsafe mechanism against hyperproliferation and might thus be induced by DNA replicative stress and oncogenic signaling, commonly termed oncogene-induced senescence (OIS). OIS has been described in several premalignant conditions such as colon adenomas and melanocytic nevi, with impaired OIS capabilities found in their malignant counterparts. Here, we analyze the possible impact of cellular senescence on malignant transformation in plasma cell disorders. Methods: Bone marrow and soft tissue biopsies from 125 patients with diff

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Khorolskyi, M. S., and S. O. Bigun. "Performance of interface hoses for thermal conditioning system of "Cyclon-4" space rocket in extreme conditions." Kosmìčna nauka ì tehnologìâ 27, no. 4 (2021): 11–20. http://dx.doi.org/10.15407/knit2021.04.011.

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This article contains the analysis of the performance of interface hoses for the thermal conditioning system of a Cyclone-4 space rocket in extreme operating conditions. thermal conditioning system interfaces with rubber hoses must ensure a tightness of a hose at a rocket’s inlet with easy detachment, involving little to no force impact on the rocket during its start on its one end, and rigid connection with a pipeline of the thermal conditioning system ground part, ensuring the hose tightness and retaining after the launch of a rocket on its other end, under any abnormal operating conditions.

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Reimann, Maurice, Christoph Loddenkemper, Cornelia Rudolph, et al. "Inactivation of the Myc−Induced DNA Damage Response Promotes Lymphomagenesis and Treatment Resistance In Vivo." Blood 108, no. 11 (2006): 774. http://dx.doi.org/10.1182/blood.v108.11.774.774.

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Abstract Activation of the DNA damage response (DDR) was recently claimed to serve as a critical anti−cancer barrier in early human tumorigenesis (Bartkova−J et al., and Gorgoulis−VG et al., Nature, 2005). As a consequence, deregulation of the DDR machinery may be required for tumor manifestation. Myc activation is an oncogenic event frequently detected in malignant lymphomas. It is known that constitutive Myc expression provokes apoptosis via the ARF/p53 pathway as a cellular failsafe mechanism to counteract malignant transformation, but the potential role of Myc signaling to the DDR machiner

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Braig, Melanie, Christoph Loddenkemper, Antoine H. F. M. Peters, et al. "Impaired Histone H3 Lysine 9 Methylation Accelerates Ras-Driven Lymphomagenesis by Disabling Cellular Senescence." Blood 104, no. 11 (2004): 346. http://dx.doi.org/10.1182/blood.v104.11.346.346.

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Abstract As a barrier against malignant transformation, checkpoint-mediated failsafe mechanisms such as apoptosis or cellular senescence may be activated in response to mitogenic oncogenes. Acute induction of oncogenic Ras has been shown to provoke a senescence-like cell-cycle arrest that involves the retinoblastoma (Rb) pathway. Recently, Rb-mediated formation of heterochromatin was identified as a critical feature of cellular senescence. Since methylation of histone H3 lysine 9 by the Rb-bound histone methyltransferase Suv39h1 contributes to the transcriptional repression of growth promoting

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Khrystyuk, Andriy, and Oleksandr Cherniuk. "From Control Loss to Autonomous Operation: Failsafe Strategies for Modern UAVs." Modeling, Control and Information Technologies, no. 7 (December 7, 2024): 342–43. https://doi.org/10.31713/mcit.2024.106.

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This paper analyzes the operating principles of the ExpressLRS radio control system for unmanned aerial vehicles (UAVs). It examines mechanisms for protecting UAVs from loss in the event of signal loss and explores various UAV behavior options in such situations. The study identifies possible ways to implement UAV protection mechanisms and highlights the potential for the UAV to perform a specific task even after radio communication with the operator is lost

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Reimann, Maurice, Soyoung Lee, Christoph Loddenkemper, et al. "Apoptotic Lymphoma Cells Evoke a Pro-Senescent Stromal Signal That Limits Lymphoma Development." Blood 114, no. 22 (2009): 2392. http://dx.doi.org/10.1182/blood.v114.22.2392.2392.

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Abstract Abstract 2392 Poster Board II-369 Introduction: Cancer entities frequently exhibiting constitutive Myc expression, such as aggressive B-cell lymphomas, typically display significant amounts of apoptotic cell death. So far, cellular senescence as another cell-autonomous oncogene-inducible safeguard program has been recognized in RAS/BRAF-driven scenarios but not as a bona fide Myc-evoked anti-cancer mechanism. Understanding how oncogenic Myc may provoke not only apoptosis but cellular senescence as a failsafe mechanism to counter tumor development has broad implications for the clinica

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Dörr, Jan, Selina Keppler, Maja Milanovic, et al. "Therapy-Inducible Senescence Activates Both Innate and Adaptive Immune Mechanisms That Control Lymphoma Growth In Vivo." Blood 118, no. 21 (2011): 107. http://dx.doi.org/10.1182/blood.v118.21.107.107.

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Abstract Abstract 107 Introduction: Premature senescence is a cellular failsafe mechanism which is induced upon various cellular insults, such as oncogene activation or exposure to DNA damaging chemotherapy. It suppresses tumor formation and acts as a barrier to tumor progression in vivo. In contrast to apoptotic cells, senescent cells are viably arrested in the G1 phase of the cell cycle. They continue to take up nutrients and interact with tumor and host cells. To what extent senescent cells alter the tumor environment and tumor-host interactions remains largely unsolved. Here, we analyze ly

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Gressel, Jonathan. "Potential failsafe mechanisms against the spread and introgression of transgenic hypervirulent biocontrol fungi." Trends in Biotechnology 19, no. 4 (2001): 149–54. http://dx.doi.org/10.1016/s0167-7799(00)01550-x.

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Augustyniak, Daria, Eliza Kramarska, Paweł Mackiewicz, Magdalena Orczyk-Pawiłowicz, and Fionnuala T. Lundy. "Mammalian Neuropeptides as Modulators of Microbial Infections: Their Dual Role in Defense versus Virulence and Pathogenesis." International Journal of Molecular Sciences 22, no. 7 (2021): 3658. http://dx.doi.org/10.3390/ijms22073658.

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The regulation of infection and inflammation by a variety of host peptides may represent an evolutionary failsafe in terms of functional degeneracy and it emphasizes the significance of host defense in survival. Neuropeptides have been demonstrated to have similar antimicrobial activities to conventional antimicrobial peptides with broad-spectrum action against a variety of microorganisms. Neuropeptides display indirect anti-infective capacity via enhancement of the host’s innate and adaptive immune defense mechanisms. However, more recently concerns have been raised that some neuropeptides ma

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Elliman, David. "Screening – potential weak links in the chain." Clinical Risk 17, no. 6 (2011): 210–13. http://dx.doi.org/10.1258/cr.2011.011a21.

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Superficially, screening programmes may seem relatively straightforward to organize. However they are much more complicated than appears at first sight. The UK National Screening Committee, set up in 1996, advises all four nations on the introduction of new screening programmes and the improvement or, less commonly, cessation of an established programme. Most of the established programmes have a Programme Centre which advises on the running of the programme and sets standards. Because true outcomes may be some years hence, these standards usually relate to the process, rather than health impro

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Daria, Augustyniak, Kramarska Eliza, Mackiewicz Paweł, Orczyk-Pawiłowicz Magdalena, and T. Lundy Fionnuala. "Mammalian Neuropeptides as Modulators of Microbial Infections: Their Dual Role in Defense versus Virulence and Pathogenesis." MDPI International Journal of Molecular Sciences 2021, no. 22(7) (2021): 3658. https://doi.org/10.3390/ijms22073658.

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The regulation of infection and inflammation by a variety of host peptides may represent an evolutionary failsafe in terms of functional degeneracy and it emphasizes the significance of host defense in survival. Neuropeptides have been demonstrated to have similar antimicrobial activities to conventional antimicrobial peptides with broad-spectrum action against a variety of microorganisms. Neuropeptides display indirect anti-infective capacity via enhancement of the host’s innate and adaptive immune defense mechanisms. However, more recently concerns have been raised that some neuropepti

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Nagalla, Somesh. "Dynamic Pricing for Electric Vehicle Charging: A Real-Time Optimization Framework for Grid Stability and Economic Efficiency." European Journal of Computer Science and Information Technology 13, no. 42 (2025): 44–53. https://doi.org/10.37745/ejcsit.2013/vol13n424453.

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Dynamic pricing systems for electric vehicle charging infrastructure represent a transformative solution to the challenges posed by rapid transportation electrification and its impact on power grid stability. This comprehensive framework integrates real-time wholesale electricity market prices, transformer loading conditions, and weather-driven renewable generation forecasts to optimize charging tariffs at five-minute intervals. The system architecture leverages OpenADR protocols for standardized communication, SCADA telemetry for grid monitoring, and advanced machine learning algorithms for d

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Guzhov, S. V., and D. V. Torop. "Calculation of the change in the technical condition index of a facility when using a device distorting power quality indicators at mass construction sites in Moscow." Safety and Reliability of Power Industry 15, no. 4 (2023): 263–69. http://dx.doi.org/10.24223/1999-5555-2022-15-4-263-269.

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The mechanisms of influence of devices distorting power quality indicators on the key electrical processes in the power supply system of the building are considered. Existing methods for compensating harmonic current and voltage fluctuations are mainly related to circuitry-based, engineering and organizational solutions. Modern engineering solutions imply supplementing electrical installations of the building with complex devices that incorporate semiconductor transducers. In addition to performing their primary function, these devices act as sources of additional emission of current and volta

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Aust, Gabriela, Irina Lehmann, Sandy Laue та Werner A. Scherbaum. "Activated and interferon-γ producing thyroid-derived T cells are detected in Graves' disease, thyroid autonomy as well as in non-toxic multinodular goiter". European Journal of Endocrinology 135, № 1 (1996): 60–68. http://dx.doi.org/10.1530/eje.0.1350060.

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Aust G, Lehmann I, Laue S, Scherbaum WA. Activated and interferon-γ producing thyroid-derived T cells are detected in Graves' disease, thyroid autonomy as well as in non-toxic multinodular goiter. Eur J Endocrinol 1996;135:60–8. ISSN 0804–4643 The relative numbers of activated and interferon gamma (IFN-γ)-producing peripheral blood lymphocytes (PBL) and thyroid-derived lymphocytes (TL) were determined using double surface and intracellular labeling techniques in flow cytometry. Cells were analyzed from 10 patients with Graves' disease (GD), eight patients with thyroid autonomy (TA) and five pa

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Zhang, Jing, Xiaolei Sun, Yimei Qian, Jeffrey P. LaDuca, and Lynne E. Maquat. "At Least One Intron Is Required for the Nonsense-Mediated Decay of Triosephosphate Isomerase mRNA: a Possible Link between Nuclear Splicing and Cytoplasmic Translation." Molecular and Cellular Biology 18, no. 9 (1998): 5272–83. http://dx.doi.org/10.1128/mcb.18.9.5272.

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ABSTRACT Mammalian cells have established mechanisms to reduce the abundance of mRNAs that harbor a nonsense codon and prematurely terminate translation. In the case of the human triosephosphate isomerase (TPI gene), nonsense codons located less than 50 to 55 bp upstream of intron 6, the 3′-most intron, fail to mediate mRNA decay. With the aim of understanding the feature(s) of TPI intron 6 that confer function in positioning the boundary between nonsense codons that do and do not mediate decay, the effects of deleting or duplicating introns have been assessed. The results demonstrate that TPI

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Fasana, Elisa, Ilaria Fregno, Carmela Galli, Tatiana Soldà, and Maurizio Molinari. "ER-to-lysosome-associated degradation acts as failsafe mechanism upon ERAD dysfunction." EMBO Reports, May 21, 2024. http://dx.doi.org/10.1038/s44319-024-00165-y.

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AbstractThe endoplasmic reticulum (ER) produces proteins destined to organelles of the endocytic and secretory pathways, the plasma membrane, and the extracellular space. While native proteins are transported to their intra- or extracellular site of activity, folding-defective polypeptides are retro-translocated across the ER membrane into the cytoplasm, poly-ubiquitylated and degraded by 26 S proteasomes in a process called ER-associated degradation (ERAD). Large misfolded polypeptides, such as polymers of alpha1 antitrypsin Z (ATZ) or mutant procollagens, fail to be dislocated across the ER

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Chen, Ming, Lixin Wan, Jiangwen Zhang та ін. "Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism". Nature Communications 9, № 1 (2018). http://dx.doi.org/10.1038/s41467-017-02272-y.

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Protasoni, Margherita, Vanessa López-Polo, Camille Stephan-Otto Attolini, et al. "Cyclophilin D plays a critical role in the survival of senescent cells." EMBO Journal, October 24, 2024. http://dx.doi.org/10.1038/s44318-024-00259-2.

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AbstractSenescent cells play a causative role in many diseases, and their elimination is a promising therapeutic strategy. Here, through a genome-wide CRISPR/Cas9 screen, we identify the gene PPIF, encoding the mitochondrial protein cyclophilin D (CypD), as a novel senolytic target. Cyclophilin D promotes the transient opening of the mitochondrial permeability transition pore (mPTP), which serves as a failsafe mechanism for calcium efflux. We show that senescent cells exhibit a high frequency of transient CypD/mPTP opening events, known as 'flickering'. Inhibition of CypD using genetic or phar

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Amarasekara, Bede Ravindra, Anuradha Mathrani, and Chris Scogings. "Online Tracking: When Does it Become Stalking?" Vietnam Journal of Computer Science, May 25, 2021, 1–21. http://dx.doi.org/10.1142/s2196888821500226.

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Online user activities are tracked for many purposes. In e-commerce, cross-domain tracking is used to quantify and pay for web-traffic generation. Our previous research studies have shown that HTTP cookie-based tracking process, though reliable, can fail due to technical reasons, as well as through fraudulent manipulation by traffic generators. In this research study, we evaluate which of the previously published tracking mechanisms are still functional. We assess the efficacy and utility of those methods to create a robust tracking mechanism for e-commerce. A failsafe and robust tracking mech

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Bender, Alexander, Füsun Boydere, Ashok Kumar Jayavelu, et al. "Redistribution of PU.1 partner transcription factor RUNX1 binding secures cell survival during leukemogenesis." EMBO Journal, November 14, 2024. http://dx.doi.org/10.1038/s44318-024-00295-y.

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AbstractTranscription factors (TFs) orchestrating lineage-development often control genes required for cellular survival. However, it is not well understood how cells survive when such TFs are lost, for example in cancer. PU.1 is an essential TF for myeloid fate, and mice with downregulated PU.1 levels develop acute myeloid leukemia (AML). Combining a multi-omics approach with a functional genetic screen, we reveal that PU.1-downregulated cells fundamentally change their survival control from cytokine-driven pathways to overexpression of an autophagy-predominated stem cell gene program, for wh

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Colon-Caraballo, Mariano, Serena R. Russell, Kristin M. Myers, and Mala Mahendroo. "Collagen turnover during cervical remodeling involves both intracellular and extracellular collagen degradation pathways." Biology of Reproduction, January 17, 2025. https://doi.org/10.1093/biolre/ioaf012.

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Abstract Reproductive success requires accurately timed remodeling of the cervix to orchestrate the maintenance of pregnancy, the process of labor, and birth. Prior work in mice established that a combination of continuous turnover of fibrillar collagen and reduced formation of collagen cross-links allows for the gradual increase in tissue compliance and delivery of the fetus during labor. However, the mechanism for continuous collagen degradation to ensure turnover during cervical remodeling is still unknown. This study demonstrates the functional role of extracellular and intracellular colla

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Xu, Hui, Jessica R. Kenneson, Laura E. Minton, and Douglas C. Goodwin. "A switch and a failsafe: KatG’s mechanism for preservation of catalase activity using a conformationally dynamic Arg and an active-site Trp." Frontiers in Chemical Biology 3 (July 10, 2024). http://dx.doi.org/10.3389/fchbi.2024.1431412.

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Many novel structural features impart a robust catalase activity to KatG that is absent from all other members of its superfamily. The conformationally dynamic “Arg switch” and oxidizable “proximal Trp” have both figured prominently in investigations of KatG structure and mechanism, but the full scope of their contributions to catalysis remains unclear. The switch (R418) appears to regulate active-site intramolecular electron transfer. The proximal Trp (W321) is a conspicuous site of radical formation, but W321•+ does not appear to participate directly in the KatG catalase cycle. To explore th

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Vasconcelos, Gabriel, Rodrigo Miani, Vitor Guizlini, and Jefferson Souza. "Evaluation of DoS attacks on Commercial Wi-Fi-Based UAVs." International Journal of Communication Networks and Information Security (IJCNIS) 11, no. 1 (2022). http://dx.doi.org/10.17762/ijcnis.v11i1.3969.

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One of the biggest challenges for the use of Unmanned Aerial Vehicles (UAVs) in large-scale real-world applications is security. However, most of research projects related to robotics does not discuss security issues, moving on directly to studying classical problems (i.e., perception, control, planning). This paper evaluates the effects of availability issues (Denial of Service attacks) in two commonly used commercially available UAVs (AR.Drone 2.0 and 3DR SOLO). Denial of Service (DoS) attacks are made while the vehicles are navigating, simulating common conditions found both by the general

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Kanthi, M., and Ravilla Dilli. "Smart streetlight system using mobile applications: secured fault detection and diagnosis with optimal powers." Wireless Networks, February 24, 2023. http://dx.doi.org/10.1007/s11276-023-03278-9.

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AbstractA street lighting system is a very essential part of the highways and streets of a smart city. Managing power consumption and maintenance of a street light system will be a challenging task in huge countries. The proposed work is mainly focused on the minimization of power consumption in the implementation of a smart street lighting system. Also, use a mobile application for setting up the brightness levels of the lamps in an encrypted form so that an unauthorized person will not be able to modify the settings. In the existing streetlight system, wireless sensors are installed to contr

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Sang, Yong, Jun Dang, Jianan Wu, and Enzhuo Quan. "Reevaluating Backup Monitor Chamber Tolerances for Stereotactic Body Radiotherapy Treatments using Volumetric-modulated Arc Therapy." Journal of Medical Physics, May 13, 2025. https://doi.org/10.4103/jmp.jmp_202_24.

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Abstract Background: Backup monitor chambers in medical linear accelerators play a critical role by verifying the radiation dose delivery and providing a failsafe mechanism to terminate the beam if dose discrepancies are detected. The American Association of Physicists in Medicine’s Task Group 142 recommends a 2% constancy tolerance for these chambers, which is suitable for conventional radiotherapy but may not be adequate for stereotactic body radiotherapy (SBRT) due to its high monitor units (MUs) per fraction. This study evaluates the backup monitor chamber constancy in SBRT treatments usin

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Amareshwari, Parunandhi, Susmitha Reddy Karnati, Sahithi Nakirtha, Vasudha ., and Sai Swetha. "A Data-Driven Engine Starter System Using ESP32 With Multi-Layer Authentication and Alerts." INTI Journal JODS, no. 2025 (2025). https://doi.org/10.61453/jods.v2025no10.

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The Data-Driven Engine Starter System using ESP32 is designed to enhance engine security by integrating multi-layer authentication mechanisms, including password input, fingerprint recognition, and RFID/NFC technology. This system prevents unauthorized engine access, ensuring only authenticated users can operate it. In addition to robust authentication, the system leverages IoT connectivity to provide real-time alerts and monitoring, allowing users to control and oversee engine activity through a mobile app or web interface. By incorporating failsafe mechanisms and cloud-based logging, the sys

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Rich, P. Dylan, Stephan Yves Thiberge, Benjamin B. Scott, et al. "Magnetic voluntary head-fixation in transgenic rats enables lifespan imaging of hippocampal neurons." Nature Communications 15, no. 1 (2024). http://dx.doi.org/10.1038/s41467-024-48505-9.

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AbstractThe precise neural mechanisms within the brain that contribute to the remarkable lifetime persistence of memory are not fully understood. Two-photon calcium imaging allows the activity of individual cells to be followed across long periods, but conventional approaches require head-fixation, which limits the type of behavior that can be studied. We present a magnetic voluntary head-fixation system that provides stable optical access to the brain during complex behavior. Compared to previous systems that used mechanical restraint, there are no moving parts and animals can engage and dise

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Wang, Zhengjin. "Fluid-Driven Cracks Tunneling in Cemented Hydrocarbon Wells." Journal of Applied Mechanics 89, no. 6 (2022). http://dx.doi.org/10.1115/1.4054093.

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Abstract Pressurized fluids may invade into the cement sheath of hydrocarbon wells during hydraulic fracturing and other construction operations in shale gas and oil exploitation. Excessive fluid pressure provides a driving force for small cracks to grow and tunnel through the length of the well, leading to the loss of zonal isolation and severe consequences. This work studies fluid-driven cracks tunneling in the bulk or along the interfaces of the cement sheath. We calculate the energy release rate of the tunneling crack as a function of the width of the tunnel. As long as the maximum energy

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Shao, Xianmin, Yijie Cai, Shunyu Yin, Tiefeng Li, and Zheng Jia. "Mechanics of interfacial delamination in deep-sea soft robots under hydrostatic pressure." Journal of Applied Mechanics, November 11, 2022, 1–19. http://dx.doi.org/10.1115/1.4056214.

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Abstract In recent years, with the increasing demand for ocean exploration, deep-sea soft robots featuring better environmental adaptability, lighter weight, and less energy consumption relative to traditional robots have emerged. Considering that deep-sea soft robots usually contain components composed of dissimilar materials in the form of layered structures, interfacial delamination is likely to occur under extreme hydrostatic pressure, which may significantly impact robot operation. Moreover, traditional numerical methods to analyze interfacial delamination with J-integral have limitations

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