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Journal articles on the topic 'FALC'

Author: Grafiati

Published: 25 May 2024

Last updated: 19 July 2025

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1

Park, Kyung-Ran, Hyun Hee Leem, Yoon-Ju Kwon, Il Keun Kwon, Jin Tae Hong, and Hyung-Mun Yun. "Falcarindiol Stimulates Apoptotic and Autophagic Cell Death to Attenuate Cell Proliferation, Cell Division, and Metastasis through the PI3K/AKT/mTOR/p70S6K Pathway in Human Oral Squamous Cell Carcinomas." American Journal of Chinese Medicine 50, no. 01 (2021): 295–311. http://dx.doi.org/10.1142/s0192415x22500112.

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Human oral squamous cell carcinomas (OSCCs) have high cancer mortality and a 5-year survival rate lower than that of most other carcinomas. New therapeutic strategies are required for the treatment and prevention against OSCCs. An approach to cancer therapy using plant-derived natural compounds has been actively in progress as a trend. Falcarindiol (FALC), or its isolated form Ostericum koreanum Kitagawa (O. koreanum), is present in many food and dietary plants, especially in carrots, and this compound has a variety of beneficial effects. However, biological activity of FALC has not been reported in OSCCs yet. This study aimed to demonstrate the antitumor effects of FALC against OSCCs, YD-10B cells. In this study, FALC was selected as a result of screening for compounds isolated from various natural products in YD-10B cells. FALC suppressed cell growth, and FALC-induced apoptotic cell death was mainly accompanied by the dephosphorylation of PI3K, AKT, mTOR, and p70S6K. The apoptotic cell death was also associated with autophagy as evidenced by the expression of Beclin-1, the conversion of LC3-II, and the formation of autophagosome. FALC-induced autophagy was accompanied by MAPKs including ERK1/2 and p38. Furthermore, FALC caused the antimetastatic effects by inhibiting the migration and invasion of YD-10B cells. Taken together, the findings suggest the potential value of FALC as a novel candidate for therapeutic strategy against OSCCs.

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Siffert, Elodie. "Rendre les musées du canton de Neuchâtel accessibles." Revue suisse de pédagogie spécialisée 14, no. 02 (2024): 31–37. http://dx.doi.org/10.57161/r2024-02-05.

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Les expertes et les experts en langage Facile à lire et à comprendre (FALC) de la Fondation Les Perce-Neige travaillent avec les médiatrices et médiateurs culturels afin de rendre les musées accessibles. Cette collaboration permet d’adapter non seulement les textes en FALC, mais également les espaces d’exposition. Depuis 2017, le groupe FALC de Neuchâtel a reçu de nombreux mandats. Dans cet article, deux expertes et trois experts FALC partagent leurs expériences.

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Kim, Yoo-Jae, Jiong Hu, Soon-Jae Lee, and Byung-Hee You. "Mechanical Properties of Fiber Reinforced Lightweight Concrete Containing Surfactant." Advances in Civil Engineering 2010 (2010): 1–8. http://dx.doi.org/10.1155/2010/549642.

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Fiber reinforced aerated lightweight concrete (FALC) was developed to reduce concrete's density and to improve its fire resistance, thermal conductivity, and energy absorption. Compression tests were performed to determine basic properties of FALC. The primary independent variables were the types and volume fraction of fibers, and the amount of air in the concrete. Polypropylene and carbon fibers were investigated at 0, 1, 2, 3, and 4% volume ratios. The lightweight aggregate used was made of expanded clay. A self-compaction agent was used to reduce the water-cement ratio and keep good workability. A surfactant was also added to introduce air into the concrete. This study provides basic information regarding the mechanical properties of FALC and compares FALC with fiber reinforced lightweight concrete. The properties investigated include the unit weight, uniaxial compressive strength, modulus of elasticity, and toughness index. Based on the properties, a stress-strain prediction model was proposed. It was demonstrated that the proposed model accurately predicts the stress-strain behavior of FALC.

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Sun, Jian, Shuyi Wu, Jinfu Chen, et al. "Optimization of Fuzzy Adaptive Logic Controller for Robot Manipulators Using Modified Greater Cane Rat Algorithm." Mathematics 13, no. 10 (2025): 1631. https://doi.org/10.3390/math13101631.

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In the control of robot manipulators, input torque constraints and system nonlinearities present significant challenges for precise trajectory tracking. However, fuzzy adaptive logic control (FALC) often fails to generate the optimal membership functions or function intervals. This paper proposes a modified greater cane rat algorithm (MGCRA) to optimize a fuzzy adaptive logic controller (FALC) for minimizing input torques during trajectory tracking tasks. The main innovation lies in integrating the improved MGCRA with FALC, which enhances the controller’s adaptability and performance. For benchmarking, several state-of-the-art swarm intelligence algorithms—including particle swarm optimization (PSO), artificial bee colony (ABC), ant colony optimization (ACO), gray wolf optimization (GWO), covariance matrix adaptation evolution strategy (CMA-ES), adaptive guided differential evolution (AGDE), the basic greater cane rat algorithm (GCRA), and a trial-and-error method—are compared under identical conditions. Experimental results show that the MGCRA-tuned FALC achieves lower input torques and improved trajectory tracking accuracy compared to other methods. The findings demonstrate the effectiveness and potential of the proposed MGCRA-FALC framework for advanced robotic manipulator control.

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Moro, Kazuyo, and Shigeo Koyasu. "Innate production of Th2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells (89.11)." Journal of Immunology 184, no. 1_Supplement (2010): 89.11. http://dx.doi.org/10.4049/jimmunol.184.supp.89.11.

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Abstract Innate immune responses are important in combating various microbes during the early phases of infection. NK cells are innate lymphocytes that, unlike T and B lymphocytes, do not express antigen receptors but rapidly exhibit cytotoxic activities against virus-infected cells and produce various cytokines. Here we report a new type of innate lymphocyte present in a novel lymphoid structure associated with adipose tissues in the peritoneal cavity. These cells do not express lineage (Lin) markers but do express c-Kit, Sca-1, IL7R and IL33R. Similar lymphoid clusters were found in both human and mouse mesentery and we term this tissue ‘FALC’ (fat-associated lymphoid cluster). FALC Lin-c-Kit+Sca-1+ cells are distinct from lymphoid progenitors and lymphoid tissue inducer cells. These cells proliferate in response to IL2 and produce large amounts of Th2 cytokines such as IL5, IL6 and IL13. IL5 and IL6 regulate B-cell antibody production and self-renewal of B1 cells. Indeed, FALC Lin-c-Kit+Sca-1+ cells support the self-renewal of B1 cells and enhance IgA production. After helminth infection and in response to IL33, FALC Lin-c-Kit+Sca-1+ cells produce large amounts of IL13, which leads to goblet cell hyperplasia—a critical step for helminth expulsion. In mice devoid of FALC Lin-c-Kit+Sca-1+ cells, such goblet cell hyperplasia was not induced. Thus, FALC Lin-c-Kit+Sca-1+ cells are Th2-type innate lymphocytes, and we propose that these cells be called ‘natural helper cells’.

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Cazorla, Dalmiro, Maritza Alarcon, and Moreno Pedro Morales. "REGISTRO DE Rasahus hamatus (Fabricius, 1781) (HEMIPTERA: HETEROPTERA: REDUVIIDAE, PEIRATINAE) EN EL ESTADO FALCÓN, VENEZUELA." Revista Nicaraguense de Entomologia 262 (February 28, 2022): 1–20. https://doi.org/10.5281/zenodo.6339686.

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Se documenta por primera vez la presencia de la “chinche cazadora de lunar amarillo” Rasahus hamatus (Fabricius, 1781) (Hemiptera: Heteroptera: Reduviidae, Peiratinae) en la ciudad de Churuguara, Municipio Federación, al sur del estado Falcón en la Sierra de Falcón (Sistema Coriano), al nor-occidente de Venezuela.

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Mammate, Naima, Fatima Ezzahra El oumari, Hamada Imtara, et al. "Antioxidant and Anti-Urolithiatic Activity of Aqueous and Ethanolic Extracts from Saussurea costus (Falc) Lispich Using Scanning Electron Microscopy." Life 12, no. 7 (2022): 1026. http://dx.doi.org/10.3390/life12071026.

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The plant Saussurea costus (Falc) Lipsch has many biological activities and a strong curative and preventive power against a variety of diseases including cancer, diabetes, and hemorrhoids. In the current study, phytochemical screening was carried out as well as an investigation of the antilithiatic and antioxidant activities of aqueous and ethanolic extracts of this plant. The results showed that aqueous and ethanolic extracts were effective in reducing cystine stone mass and that the aqueous extract of Saussurea costus (Falc) Lipsch had the highest percentage of dissolution (6.756 ± 1.024) (p < 0.05). A turbidimetric method and a crystallization test were used to evaluate the antilithiatic activity of an aqueous and ethanolic extract of this plant on calcium oxalate crystallization. The results of these methods revealed that the ethanolic extract of this plant has a significant inhibitory effect on calcium oxalate crystallization, with a percentage inhibition of (91.017 ± 0.299) (p < 0.05) for a concentration of 2 mg mL−1. The DPPH method revealed that the ethanolic extract of Saussurea costus (Falc) Lipsch with a concentration of (IC50 = 0.12325 mg mL−1) had the highest IC50, whereas the FRAP method revealed that the aqueous extract of Saussurea costus (Falc) Lipsch with a concentration of 300 µg mL−1 has the most significant reducing power with (OD = 0.56 ± 0.05). These findings indicate that aqueous and ethanolic extracts of Saussurea costus (Falc) Lipsch had a significant effect on whewellite and weddellite and a greater free radical scavenging effect but had no effect on cystine dissolution.

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Deng, Meihong, Yiming Li, Tianmeng Chen, Kong Chen, and Timothy R. Billiar. "Roles of Toll-like Receptors in Regulating Fibroblastic Reticular Cells Pathobiology during Sepsis." Journal of Immunology 202, no. 1_Supplement (2019): 183.5. http://dx.doi.org/10.4049/jimmunol.202.supp.183.5.

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Abstract Fibroblastic reticular cells (FRCs), a subpopulation of stromal cells in lymphoid organs and fat-associated lymphoid clusters (FALCs) in peritoneal fat, play immune-regulatory roles in the host defense. However, the mechanisms underlying the regulation of FRC pathobiology, especially in response to Toll-like receptor (TLR) signaling is unclear. Therefore, we aimed to understand the roles of TLR signaling in FRC pathobiology during sepsis. FALC cells were isolated from mesenteric adipose tissue in wild-type mice before and after cecal ligation and puncture (CLP). The transcriptomic profile of FALC cells were assessed using single cell RNA sequencing. Notably, FRCs were a major population of FALC cells (50 +/− 10.2 % in control, 30 +/− 8.6% in CLP). One population of FRCs were identified in control mice, and two populations of FRCs were identified in CLP mice. According to gene set enrichment analysis, FRCs after CLP are enriched in gene expression associated with inflammatory response and chemotaxis. Interestingly, activation of TLR4 (LPS) and TLR3 (Poly I:C) signaling in mesenteric adipose tissue derived FRCs significantly increased the expression of chemokines known to attract neutrophils (Cxcl2 and Cxcl5), monocytes (Cxcl3), and lymphocytes (Cxcl13 and Ccl20), while activation of TLR9 (ODN1518) significantly decreased these chemokine gene expressions. Importantly, we found similar regulatory effects of TLR3, 4, and 9 on chemokine production in human adipose tissue-derived FRCs. Together, our results indicate that TLRs plays critical roles in regulating chemokine production by FRCs. These data form a knowledge basis upon which to design new therapeutic strategies of FRC-based treatments for sepsis.

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Пайдаркіна, Анастасія Петрівна, та Оксана Георгіївна Кущ. "Особливості будови лімфоїдної тканини серозних оболонок щурів у нормі і при спайковій хворобі". Intermedical journal, № 1 (31 травня 2024): 160–64. http://dx.doi.org/10.32782/2786-7684/2024-1-25.

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Вступ: З числа абдомінальних порушень внаслідок воєнних дій через післяопераційні ускладнення близько 20% пацієнтів страждають від прогресуючого спайкового процесу. А 30% пацієнтів вимушені вдаватися до повторних операційних заходів через спайкову непрохідність кишківника. Досі до кінця не з’ясовано патогенез спайкової хвороби. Необхідним залишається дослідження механізму формування спайок в черевній порожнині при спайковій непрохідності для розробки тактики та комплексного підходу до їх лікування. SALC та FALC були описані як важливі центри забезпечення першої лінії захисту в структурі слизових оболонок за рахунок вродженого і набутого імунітету. Фізіологічне значення тісного зв'язку лімфоїдних кластерів з вісцеральною і парієтальною очеревиною потребує подальшого вивчення. Мета: дослідити особливості топографії і кількості лімфоїдних кластерів, асоційованих з жировою тканиною FALC і асоційованих з серозною оболонкою SALC в нормі і при спайковій хворобі у щурів. Методологія та методи дослідження: препарування, макроскопічний, мікроскопічний, гістологічний (виготовлення плівкових препаратів), забарвлення гематоксиліном і еозином, математичний. Виклад основного матеріалу дослідження: Результати показали, що існують суттєві особливості та відмінності в структурі спайок в залежності від терміну і стадії захворювання. Площа серозоасоційованих SALC і FALC варіювала на кожному терміні розвитку спайкової хвороби. У піддослідних тварин на 14 та 21 добу виявлено, що лімфоїдні кластери мали переважно неправильну витягнуту форму та локалізувалися переважно біля кровоносних судин. Загальний топографічний малюнок молочних плям в експериментальних групах був подібним до такого у тварин інтактної групи, але впродовж експерименту спостерігалося збільшення їх діаметра та кількості скупчень. Висновки з дослідження. Дослідження показали, що спайкова хвороба характеризується збільшенням розмірів лімфоїдних кластерів SALC i FALC і їх кількості на досліджувану одиницю площі брижі кишківника з 7 по 21 день експериментального моделювання: на 7 добу спостерігали поодинокі дрібні грануляції розміром 0,6-0,8 мм; на 14 добу виявлено 4,5 SALC і 3,1 FALC на досліджувану площу, білі зернисті скупчення розміром 0,5-1,3 мм; на 21 добу – рясне скупчення овальних білуватих структур діаметром 1,2-1,8 мм у кількості 7,2 і 9,1 на досліджувану площу відповідно.

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Jiang, Ting, Yiming Li, Tianmeng Chen, et al. "TLR9 modulates peritoneal immunity via regulating the biology of CD9hi fibroblastic reticular cells." Journal of Immunology 206, no. 1_Supplement (2021): 111.12. http://dx.doi.org/10.4049/jimmunol.206.supp.111.12.

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Abstract Fibroblastic reticular cells (FRC) are highly heterogeneous. Distinct FRC subsets play unique roles in the formation of secondary lymphoid organs and immune responses. We have previously shown that TLR9 signaling plays a critical role in regulating peritoneal immunity via suppressing chemokine production in FRC in the fat associated lymphoid clusters (FALC). However, the subset-specific roles of TLR9 in FRC of FALCs remain unknown. Using single-cell RNA-sequencing, we identified three distinct subsets of FRC (CD55hi, CD9hi and CD55loCD9lo) in mouse mesenteric FALCs at baseline. Based on the gene set enrichment analysis, the Cd55hi subset was enriched in gene expression related to cell differentiation. The CD9hi subset was enriched in gene expression related to immune response. The CD55loCD9lo subset was enriched in the gene expression related to extracellular matrix formation. Furthermore, we found that CD9hi FRC from Tlr9−/− mice increased gene expression associated with inflammation. Using flow cytometry and bulk-RNA seq, we successfully isolated and validated these three subsets in mouse FALCs. Interestingly, activation of TLR9 signaling using ODN1585 significantly decreased CD9 expression in FRC in vivo and in vitro. Furthermore, treatment of ODN1585 suppressed the proliferation of CD9hi FRC, evidenced by decreased expression of Ki67. These results indicate that CD9hi FRC in FALC are immunoregulatory. TLR9 signaling may modulate peritoneal immunity via regulation of the proliferation of CD9hi FRC. Understanding the mechanism of how TLR9 regulates CD9hi FRC may lead to discovering new therapies for inflammatory diseases.

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11

Bénézech, C., NT Luu, JA Walker, et al. "Inflammation-induced formation of fat-associated lymphoid clusters." Nat Immunol 16, no. 8 (2015): 819–28. https://doi.org/10.1038/ni.3215.

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Fat-associated lymphoid clusters (FALCs) are a type of lymphoid tissue associated with visceral fat. Here we found that the distribution of FALCs was heterogeneous, with the pericardium containing large numbers of these clusters. FALCs contributed to the retention of B-1 cells in the peritoneal cavity through high expression of the chemokine CXCL13, and they supported B cell proliferation and germinal center differentiation during peritoneal immunological challenges. FALC formation was induced by inflammation, which triggered the recruitment of myeloid cells that expressed tumor-necrosis factor (TNF) necessary for signaling via the TNF receptors in stromal cells. Natural killer T cells (NKT cells) restricted by the antigen-presenting molecule CD1d were likewise required for the inducible formation of FALCs. Thus, FALCs supported and coordinated the activation of innate B cells and T cells during serosal immune responses.

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Rodríguez Vázquez, Silvia, Abigail Kaplan, Pierrette Bouillon, Cornelia Griebel, and Razieh Azari. "La traduction automatique des textes faciles à lire et à comprendre (FALC) : une étude comparative." Meta 67, no. 1 (2022): 18–49. http://dx.doi.org/10.7202/1092189ar.

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Au cours de la dernière décennie, les langages contrôlés (LC) ont toujours été l’objet d’une attention accrue en traduction automatique (TA). La majorité des études ont porté sur l’impact des LC sur la qualité du produit final de la TA, mais très peu d’entre elles se sont intéressées à l’impact de la TA sur l’accessibilité des textes cibles pour les personnes à besoins particuliers. Cet article vise à combler cette lacune. Il cherche à déterminer, par le biais d’une étude linguistique comparative, si les systèmes de TA génériques constituent une option viable pour produire, à partir de textes simplifiés sources, des textes cibles faciles à lire et à comprendre (FALC). Nous avons testé trois outils génériques de TA (DeepL, Google Translate et Yandex) avec des textes FALC de trois domaines différents, dans quatre paires de langues. Les résultats montrent que DeepL est l’outil le plus performant et que l’espagnol et les textes administratifs restent ceux qui occasionnent le plus de problèmes pour la TA. En ce qui concerne l’évaluation de l’accessibilité linguistique, les problèmes aux niveaux lexical et stylistique sont les plus nombreux. Même si la TA ne produit pas encore des textes FALC acceptables, notre étude en souligne le potentiel et met l’accent sur la difficulté de créer du contenu multilingue accessible pour tous.

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CAZORLA, DALMIRO, Maritza Alarcón, SONIA ARAUJO, and Gabriel Alarcón. "APORTES SOBRE POLILLAS (LEPIDOPTERA) EN LOS ESTADOS FALCÓN Y MÉRIDA, VENEZUELA. I. ARCTIINI (EREBIDAE: ARCTIINAE)." Revista nicaragüense de Entomología 380 (May 12, 2025): 1–38. https://doi.org/10.5281/zenodo.15392080.

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Se reporta la presencia de 19 taxones de “polillas tigre” (Lepidoptera: Erebidae: Arctiinae, Arctiini) en dos regiones geográficas de Venezuela [nor-occidental (estado Falcón) y andina (estado Mérida)], incluyendo 6 de la subtribu&ensp;Euchromiina [<em>Lepidoneiva teuthras</em> (Walker, 1854),<strong><em> </em></strong><em>Saurita cassandra </em>(Linnaeus, 1758) (<strong>Nuevos registros para el estado Falcón</strong>), <em>Mesothen nomia </em>Druce, 1900 (<strong>Nuevo registro para Venezuela</strong>), <em>Sarosa helotes </em>Druce, 1900, <em>Dycladia </em> <em>corribioides</em> Felder, 1869 (<strong>Nuevos registros para la región andina</strong>), <em>Macrocneme </em>Hübner, 1818],<strong> </strong>9 de<strong> </strong>la subtribu Ctenuchina<em> </em>[<em>Aclytia heber </em>(Cramer, 1780), <em>Nelphe </em>cf<em>. setosa </em>(Sepp, 1830) (<strong>Nuevos registros para el estado Falcón</strong>), <em>Eucereon tigrata </em>Herrich-Schäffer, 1855 (<strong>Nuevo registro para el estado Mérida</strong>), <em>Episcepsis hypoleuca </em>Hampson, 1898, <em>Coreura albicosta</em> Draudt, 1915 (<strong>Nuevos registros para Venezuela</strong>),<em> Eucereon costulata </em>Herrich-Schäffer, 1855, <em>Trichura esmeralda </em>(Walker, 1854), <em>Cyanopepla alonzo </em>Butler, 1876 (<strong>Nuevos registros para la región andina</strong>), <em>Dinia mena </em>(Hübner, 1827) (<strong>Nuevo registro para la Parroquia Arias</strong>)], 3 de la subtribu Pericopina [<em>Dysschema sacrifica </em>(Hübner, 1831) (<strong>Nuevo registro para el estado Falcón</strong>), <em>Hyalurga fenestra </em><em>Linnaeus, 1758 (</em><strong>Nuevo registro para la Parroquia Arias</strong><em>),</em> <em>Dysschema marginalis </em>(Walker, 1854) (<strong>Nuevo registro para la región andina</strong>)] y 1 de la subtribu Phaegopterina [<em>Amastus thalassina </em>Herrich-Schäffer, 1858) (<strong>Nuevo registro para la Parroquia Osuna Rodríguez</strong>)].

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Ko, J., D. Lee, H. Park, E. A. Coutsias, J. Lee, and C. Seok. "The FALC-Loop web server for protein loop modeling." Nucleic Acids Research 39, suppl (2011): W210—W214. http://dx.doi.org/10.1093/nar/gkr352.

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Zaky, Kerollos, Yara Abdelaal, Areeij Ashour, Tasneem Zeid, Taha Hussien, and Amany Ahmed. "Pharmacognostical studies on roots of Saussurea costus (Falc.) Lipsch." Sphinx Journal of Pharmaceutical and Medical Sciences 4, no. 1 (2022): 15–25. http://dx.doi.org/10.21608/sjpms.2022.164141.1015.

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Irfan Ullah, Irfan Ullah, Jamshaid Ali Khan Jamshaid Ali Khan, Achyut Adhikari Achyut Adhikari, Peer Abdul Hannan Peer Abdul Hannan, Faisal Shakeel Muhammad Kifayatullah Faisal Shakeel Muhammad Kifayatullah, and Ajmal Khan and Shafiq Ur Rahman Ajmal Khan and Shafiq Ur Rahman. "GCMS Analysis and In-Vitro Activities of Monotheca buxifolia (Falc.) A. DC. Fruit." Journal of the chemical society of pakistan 41, no. 1 (2019): 143. http://dx.doi.org/10.52568/000709/jcsp/41.01.2019.

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The aim of the current study was to evaluate various fractions of Monotheca buxifolia fruit chemically using GC-MS and in vitro antibacterial, antifungal, and leishmanicidal potentials in order to provide scientific evidences for its folk uses. A variety of pharmacologically active compounds were identified including hexadecanoic acid, oleic acid, vaccinic acid, and pthanlic acid. All the tested samples were found fairly effective in antibacterial assay, P. aeruginosa was found more susceptible to ethyl acetate fraction with inhibition of 69.5 %, while B. subtilis was found completely resistant. Similarly the growth of M. canis and F. solani were moderately inhibited by M. buxifolia. The maximum (50%) antifungal effect was observed in case of ethyl acetate fraction against F. solani, While no leishmanicidal activity was found in the entire tested samples. Yet the use of this plant can be validated in the management of different bacterial and fungal infections.

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Dalmiro, Cazorla, Alarcon Maritza, and Morales Moreno Pedro. "Presencia de Coryzorhaphis cruciata STAL, 1870 (Heteroptera: Pentatomidae, Asopinae) en Coro, Estado Falcon, Venezuela." Revista Nicaraguense de Entomologia 247 (September 6, 2021): 1–21. https://doi.org/10.5281/zenodo.5472167.

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Se reporta por primera vez la presencia en Coro, estado Falcón, al noroccidente de Venezuela, de la especie de pentatómido (chinches hediondos o verdaderos) (Hemiptera: Heteroptera: Pentatomomorpha: Pentatomidae) Coryzorhaphis cruciata Stål, 1870 (Asopinae).  

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Reyes-Céspedes, Andrés E., Alfredo A. Carlini, and Jorge D. Carrillo-Briceño. "New record of Pachyarmatherium (Cingulata: Pachyarmatheriidae) from the Late Pleistocene in Venezuela." Anartia. Publicación del Museo de Biología de La Universidad del Zulia, no. 35 (May 19, 2023): 7–13. https://doi.org/10.5281/zenodo.7951590.

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The Falcón state, in northwestern Venezuela, preserves one of the oldest localities documenting human presence on the Americas in association with megafauna remains. One of these localities is the Late Pleistocene Taima-Taima site, which is located in the vicinity of the Caribbean coast. Excavations since the 1960s in the Taima-Taima site, and surroundings, have offered new insights into the faunal assemblages that inhabited this arid coastal savannah region during the Late Pleistocene. Isolated osteoderms collected in recent prospections allow us to report here the presence of the extinct cingulate <em>Pachyarmatherium </em>cf. <em>brasiliense </em>and <em>Pachyarmatherium </em>sp. from the Taima-Taima site, and the new locality Cucuruchú (Las Dunas). The record of these taxa in the Late Pleistocene of the Falcón state increases the known paleodiversity of Cingulata for the region and expands the geographical distribution of the genus, which is poorly known in South America.

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Semwal, R. B., K. Joshi, A. Pandian, P. P. Badoni, and D. K. Semwal. "Biological applications and secondary metabolites of Saussurea costus (Falc.) Lipsch." JOURNAL OF CONVENTIONAL KNOWLEDGE AND HOLISTIC HEALTH 4, no. 01 (2020): 1–8. http://dx.doi.org/10.53517/jckhh.2581-3331.412020201.

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Saussurea costus (Falc.) Lipsch. (Compositae), popularly known as Kuth in Ayurveda, is useful for gastrointestinal disorders in the form of a digestive agent, anti-gastric agent or an appetizer. Its roots have been used in respiratory problems like cough and asthma. The plant is also used in various other traditional medicinal systems including Unani. A number of scientific reports have proved its therapeutic importance as anti-gastric, anti-asthmatic, antispasmodic, antimicrobial and anti-inflammatory agent. A variety of secondary metabolites including sesquiterpenoid lactones, lignins, and phytosterols have been identified as bioactive principles from the roots of this plant. Today, many healthcare products are available in the market those contain S. costus roots as single or in the form of a polyherbal formulation. According to the IUCN Red List, S. lappa is under the threatened category and due to its high demand in the market, it is becoming extinct very fast from its natural habitat. Hence, there is an urgent need to protect the plant by promoting its cultivation on a large scale.

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Kim, Byung Soo, Young Bae Kim, and Duck Kyun Choi. "Effect of Pattern Shape on the Crystallization in FALC Process." Materials Science Forum 475-479 (January 2005): 1845–48. http://dx.doi.org/10.4028/www.scientific.net/msf.475-479.1845.

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Considering practical application of field aided lateral crystallization process in channel region of thin film transistors, there might be a different crystallization behavior dependent on the shape of channel to be crystallized. In this study, channel array with various aspect ratios was prepared and the Cu field aided lateral crystallization process was carried out at 500ı for 10 hours with applying 30V/200㎛ through common electrodes for the sake of the actual channel area crystallization. Both the fraction of crystallized area and the degree of crystallization increase as the aspect ratio of channel become away from 1.

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Dominguez, Joseph, Jiseon Kim, Seung Hyeon Kim, Hannah Adams, Burkhard Ludewig, and Ki-wook Kim. "The role of CX3CR1+ FALC-associated macrophages in health and inflammation." Journal of Immunology 212, no. 1_Supplement (2024): 0980_5189. http://dx.doi.org/10.4049/jimmunol.212.supp.0980.5189.

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Abstract The omentum is a visceral adipose tissue that contains fat-associated lymphoid clusters (FALC) to aid in peritoneal immunity. These clusters consist of large aggregates of lymphocytes, dendritic cells, macrophages, and innate lymphoid cells that participate in the clearance of pathogens. Tissue-resident macrophages (TRM) are immune cells found in every tissue and can be defined by their origins, consisting of subsets maintained either by embryonic precursors or by bone-marrow progenitors. A recent study found embryonically derived TRM express at least one marker amongst Tim4, LYVE1, FOLR2 while bone marrow derived macrophages maintain CCR2 expression. Previous publications have shown the existence of LYVE1+ macrophages surrounding each cluster, here we study an unexamined subset of FALC-associated macrophages that are imbedded within the lymphoid structures. Using confocal imaging, flow cytometry analysis with reporter/ conditional knock-out mice, we have characterized this TRM subset as CX3CR1+ Tim4- LYVE1lo/- and CCR2 dependent. In addition, we examined the interaction between CX3CR1+ macrophages and CCL19+ fibroblastic reticular cells by generating CCL19-driven Csf1 depleted mice and found CX3CR1+ macrophages were partially depleted. Lastly, we looked at the role of tissue-resident macrophages in the omentum in early ovarian tumor burden and found omental/peritoneal TRM macrophage depletion by Wt1-driven Csf1 depletion led to increased tumor burden.

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Suárez, Luis, and Dilso Gutiérrez. "EVALUACIÓN DEL COMPORTAMIENTO AGRONÓMICO DE SEIS GENOTIPOS DE TÁRTAGO (Ricinus communis L) EN EL SEMIÁRIDO FALCONIANO." Observador del Conocimiento VOL 2. N° 3 MARZO 2014, no. 2343-6212 (2022): 187–96. https://doi.org/10.5281/zenodo.6819150.

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El cultivo del tártago (Ricinus communis L) representa una alternativa viable con ventajas comparativas para ser sembrado en las zonas áridas y semiáridas del estado Falcón: Esta planta es una oleaginosa cuyo aceite se utiliza actualmente para la producción de biodisiel. Se evaluó el comportamiento agronómico de seis cultivares de tártago en la Unidad de Apoyo Académico “Ing. José Landaeta”, ubicada en Coro, municipio Miranda del estado Falcón. Se utilizó un diseño en bloques al azar con seis tratamientos y cuatro repeticiones. Se analizaron las características agronómicas en la planta, racimos, frutos, semillas y rendimiento de semillas (Kg/ha). Existieron diferencias significativas en la respuesta de los genotipos para la mayoría de las variables. El cultivar criollo Cola de Caballo presentó el mayor rendimiento de semilla, mientras que el Local de Santa Rosa fue el de menor productividad.

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Rana, C.S., and D.S. Rawat. "New floral distribution records of Aquilegia nivalis (Baker) Falc. ex B.D. Jacks and Doronicum falconeri C.B. Clarke ex Hook. f. from the Valley of Flowers National Park, Uttarakhand, India." Journal of Threatened Taxa 4, no. 9 (2012): 2911–14. https://doi.org/10.11609/JoTT.o3036.2911-4.

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Rana, C.S., Rawat, D.S. (2012): New floral distribution records of Aquilegia nivalis (Baker) Falc. ex B.D. Jacks and Doronicum falconeri C.B. Clarke ex Hook. f. from the Valley of Flowers National Park, Uttarakhand, India. Journal of Threatened Taxa 4 (9): 2911-2914, DOI: 10.11609/JoTT.o3036.2911-4, URL: http://threatenedtaxa.org/index.php/JoTT/article/view/794

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CAZORLA, DALMIRO, and Maritza Alarcón. "REGISTRO DE LA AVISPA SOCIAL Agelaia bequaerti (Richards, 1951) (HYMENOPTERA: VESPIDAE) EN EL ESTADO FALCÓN, VENEZUELA." Revista nicaragüense de Entomología 365 (December 27, 2024): 1–18. https://doi.org/10.5281/zenodo.14562353.

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Se registra por primera vez la presencia de la especie de “avispa social” <em>Agelaia bequaerti</em> (Richards, 1951)<strong> </strong>(Hymenoptera: Vespidae: Polistinae: Epiponini)  en la población de<strong> </strong>El Mamón, Sierra de San Luis, estado Falcón al nor-occidente de Venezuela.

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Falciati, Luca, Michela Balconi, Chiara Cobelli, and Claudio Maioli. "Effects of spatial cueing on overt orienting of gaze to attentive stimuli." Neuropsychological Trends, no. 15 (April 2014): 25–33. http://dx.doi.org/10.7358/neur-2014-015-falc.

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The latency of visually guided saccades executed after a cueing condition was adopted as a more ecological index to explore how spatial attention, usually assessed by manual responses, operates in the visual field. Subjects executed saccades aimed towards one of 4 possible positions, equally distributed around a central fixation cross. Before the onset of the saccadic target, a visual cue was briefly presented at the same or at a different spatial location. The visual cue was non-predictive of the target position. Two experimental sessions were carried out, differing for the onset asynchrony between cue and target. A time-dependent coupling between the task-irrelevant location of the cue and the direction of a following overt shift of attention emerged. Clinical applications of the adopted experimental setting to neurological and psychiatric patients with motor impairments are discussed.

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Falcinelli, Alessandro. "Modalidad epistémica y adverbios de duda: el caso de «magari» en italiano." Linguæ & - Rivista di lingue e culture moderne, no. 14 (2015) 2 (December 2015): 29–46. http://dx.doi.org/10.7358/ling-2015-002-falc.

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Alarcon, Maritza, and Dalmiro Cazorla. "Descripcion de casos teratologicos en Antiteuchus tripterus (Fabricius, 1787) (Heteroptera: Pentatomidae: Discocephalinae: Discocephalini)." Revista Nicaraguense de Entomologia 253 (January 17, 2022): 1–19. https://doi.org/10.5281/zenodo.5860589.

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Se describen siete casos teratológicos en ejemplares de ninfas (IV, V) y adultos (macho, hembra) de Antiteuchus tripterus (Fabricius, 1787) (Heteroptera: Pentatomidae: Discocephalinae: Discocephalini) de La Parroquia Juan Rodríguez Suárez, estado Mérida, y Coro, estado Falcón, Venezuela. La mayoría de los casos correspondieron a oligomerias antenales.  

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Cazorla, Dalmiro, Maritza Alarcon, and Moreno Pedro Morales. "REGISTRO DE Aedes (Stegomyia) albopictus (Skuse, 1894) (DIPTERA: CULICIDAE, CULICINAE) EN EL ESTADO FALCÓN, VENEZUELA." Revista Nicaraguense de Entomologia 260 (February 28, 2022): 1–14. https://doi.org/10.5281/zenodo.6339666.

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Se reporta por primera vez la presencia en la ciudad de Churuguara, en la Sierra del estado Falcón, al nor-occidente de Venezuela, de la especie de mosquito “tigre asiático” Aedes (Stegomyia) albopictus (Skuse, 1894) (Diptera: Culicidae, Culicinae, Aedini), vector de arbovirus de importancia sanitaria como el virus del dengue (DENV) (Flavivirus, Flaviridae).

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Cazorla, Dalmiro, and Maritza Alarcón. "PRIMER REGISTRO DEL ESCARABAJO PULGA Disonycha spilotrachela Blake, 1928(COLEOPTERA: CHRYSOMELIDAE: GALERUCINAE: ALTICINI) EN VENEZUELA." Revista nicaragüense de Entomología 329 (December 26, 2023): 1–27. https://doi.org/10.5281/zenodo.10432949.

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Se presenta el primer registro en Venezuela de la especie de escarabajo pulga <em>Disonycha spilotrachela</em> Blake, 1928 (Coleoptera: Chrysomelidae: Galerucinae: Alticini). Varios adultos fueron capturados alimentándose sobre la planta<em> Passiflora foetida </em>L. (maracuyá silvestre, parcha silvestre) (Passifloraceae), en un área comercial de la ciudad de Coro, estado Falcón.

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CAZORLA, DALMIRO, and Maritza Alarcón. "REGISTRO DE Tropidacris collaris (Stoll, 1813) (ORTHOPTERA: ACRIDOIDEA: ROMALEIDAE: TROPIDACRINI) EN LA SIERRA DE SAN LUIS, ESTADO FALCÓN, VENEZUELA." Revista nicaragüense de Entomología 376 (April 10, 2025): 1–23. https://doi.org/10.5281/zenodo.15191186.

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Se registra por primera vez la presencia de la especie de “saltamontes gigante o alas azules” <em>Tropidacris collaris </em>(Stoll, 1813) (Orthoptera: Acridoidea: Romaleidae, Romaleinae: Tropidacrini)<strong> </strong>en la población de<strong> </strong>El Mamón, Sierra de San Luis, estado Falcón al nor-occidente de Venezuela.

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Ehsan, Maryam, Muhammad Ibrar, Fazal Hadi, and Barkatullah Khan. "Pharmacognostic and Physico-chemical Standardization of Monotheca buxifolia (Falc.) A. DC." Biological Sciences - PJSIR 63, no. 2 (2020): 77–85. http://dx.doi.org/10.52763/pjsir.biol.sci.63.2.2020.77.85.

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Monotheca buxifolia is an ethno-medicinally important plant of Pak-Afghan regions. The pharmacognostic standards of fruit, leaf, seed, barks of stem and root were set in present study. Microscopy revealed characteristic distinguishable powder drug fragments. Each part showed certain unique florescence behaviour with various reagents under light of various wavelengths. It has a broad spectrum phytochemical profile including amino acids and proteins, fats (fixed oils), sugars (both non reducing and reducing), alkaloids, flavonoids, glycosides, tannins, triterpenoids, phenolics, saponins, phytosterols and anthocyanins. The fruit had 15.5% moisture contents seed and leaf had 8.5% each and stem and root bark had 9.5% each. The values of total ash were 7.0, 6.0, 4.5, 8.25 and 11.75%; values of water soluble ash were 4.9, 3.5, 0.5, 4.2 and 6.75%, while the values of acid insoluble ash 1.5, 1.75, 4.0, 3.75 and 4.25% in fruit pulp, leaf, stem bark, root bark and seeds, respectively. The fixed oil yield of M. buxifolia was measured to be 8.33, 10.62 and 0.56% in fruit pulp, seeds and leaves, respectively. Palmitic acid, Oleic acid, Linolenic acid, Stearic acid and Myristic acid were the most frequently found fatty acids in each part. The plant is a rich source of phosphorus, nitrogen and potassium. The plant contained safe amounts of tested trace elements as directed by WHO except for cobalt in root bark (10.7±0.01) and lead in stem bark (22.48±0.33). 

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Ali, Saima, Muhammad Rashid Khan, and Raees Khan. "Green synthesized AgNPs from Periploca hydaspidis Falc. and its biological activities." Microscopy Research and Technique 84, no. 10 (2021): 2268–85. http://dx.doi.org/10.1002/jemt.23780.

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Song, Yue-Yue, Ting-Ting Zhang, Hui Tang, et al. "The complete mitochondrial genome of Aucklandia lappa Decne. (Asteraceae, Aucklandia Falc.)." Mitochondrial DNA Part B 6, no. 6 (2021): 1691–93. http://dx.doi.org/10.1080/23802359.2021.1914524.

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CAZORLA, DALMIRO, and Maritza Alarcón. "REGISTRO DE Chromacris speciosa (Thunberg, 1824)(ORTHOPTERA: ACRIDOIDEA: ROMALEIDAE) EN EL ESTADO FALCON, VENEZUELA." Revista nicaragüense de Entomología 346 (June 8, 2024): 1–17. https://doi.org/10.5281/zenodo.11528727.

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Se registra por primera vez la presencia del “saltamonte soldado” <em>Chromacris speciosa</em> (Thunberg, 1824)(Orthoptera: Acridoidea: Romaleidae, Romaleinae: Romaleini)<strong> </strong>en la población de<strong> </strong>El Mamón, Sierra de San Luis, estado Falcón al nor-occidente de Venezuela. Se detectó un espécimen adulto sobre planta de <em>Jatropha gossypiifolia</em> L. (Euphorbiaceae).

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CAZORLA, DALMIRO, and Maritza Alarcón. "APORTES SOBRE Astylus lebasi Champions, 1918 (COLEOPTERA: MELYRIDAE: MELYRINAE, ASTYLINI) EN VENEZUELA." Revista nicaragüense de Entomología 375 (April 6, 2025): 1–38. https://doi.org/10.5281/zenodo.15161284.

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Se documenta la presencia de la especie de escarabajo <em>Astylus lebasi</em><em> </em>Champions, 1918 (Coleoptera: Melyridae: Melyrinae, Astylini) en El Mamón, Sierra de San Luis, estado Falcón (región nor-occidental) y la Parroquia Osuna Rodríguez, Mérida, estado Mérida (región andina), Venezuela. Adicionalmente, se provee información sobre plantas hospedadoras o asociadas.

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CAZORLA, DALMIRO, and Maritza Alarcón. "NUEVOS APORTES SOBRE CERAMBYCIDAE (COLEOPTERA: CERAMBYCINAE, LAMIINAE) DE VENEZUELA." Revista nicaragüense de Entomología 362 (December 17, 2024): 1–82. https://doi.org/10.5281/zenodo.14503930.

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Se reporta la presencia de 11 especies/subespecies de Cerambycidae (escarabajos longicornios) (Coleoptera: Polyphaga: Chrysomeloidea) en dos regiones geográficas de Venezuela [nor-occidental (estado Falcón) y andina (estado Mérida)], incluyendo 8 especies de Cerambycinae [<em>Achryson surinamum</em> (L., 1767) (Achrysonini),<strong><em> </em></strong><em>Chlorida festiva</em> (Linnaeus, 1758) (Bothriospilini),<em> Eburia</em> <em>semipubescens</em> (Thomson, 1861) (Eburiini)<strong><em> </em></strong>(<strong>Nuevos registros para el estado Mérida</strong>),<em> Andraegoidus rufipes </em>(Fabricius, 1787) (Trachyderini, Trachyderina)<em> </em>(<strong>Nuevo registro para Venezuela</strong>),<em> Ancylosternus morio morio</em> (Fabricius, 1787) (Trachyderini, Trachyderina), <em>Ironeus pulcher</em><em> </em>Bates, 1880 (Elaphidiini),<em> Psyrassa cuprina</em> García & Toledo-Hernández, 2022 (Elaphidiini)  (<strong>Nuevos registros para el estado Falcón o Sierra de San Luis</strong>), <em>Pantonyssus nigriceps </em>Bates, 1880 (Elaphidiini) (<strong>Nuevo registro para Venezuela</strong>)],<strong> </strong>y<strong> </strong>3 de<strong> </strong>Lamiinae<em> </em>[<em>Aegomorphus nigricans</em> (Lameere, 1884) (Acanthoderini), <em>Lagocheirus araneiformis</em> <em>fulvescens</em> Dillon, 1957 (Acanthocinini) y<strong><em> </em></strong><em>Neoptychodes trilineatus</em><strong> </strong>(Linnaeus, 1771)<strong> (</strong>Lamiini)  (<strong>Nuevos registros para el estado Mérida</strong>)].

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Jung, Jae Hoon, Ji Hoon Shin, Young Je Cho, Duck Kyun Choi, and Young Bae Kim. "Characteristics of various instability in Ni-FALC poly-Si thin film transistors." Current Applied Physics 11, no. 4 (2011): S186—S188. http://dx.doi.org/10.1016/j.cap.2011.01.056.

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Camell, Christina, and Vishwa Deep Dixit. "AGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASIS." Innovation in Aging 3, Supplement_1 (2019): S106. http://dx.doi.org/10.1093/geroni/igz038.397.

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Abstract Visceral adiposity in elderly is associated with alterations in adipose tissue immune cells leading to inflammation and metabolic dysfunction. The Nlrp3 inflammasome is a critical regulator of macrophage activation, inflammation, and immunometabolism in visceral adipose tissue during aging; however, the potential contribution of adipose tissue B cells is unexplored. Here, we show that aging expands adipose-resident B cells and fat-associated lymphoid clusters (FALCs) in visceral white adipose tissue of female mice. Adipose tissue B cells exhibit a memory-like B cell profile similar to the phenotype of aged B cells that are increased in spleen of old mice. Mechanistically, the age-induced FALC formation and adipose B cell expansion, but not B cell transcriptional program, is dependent on the Nlrp3 inflammasome. Furthermore, B cell depletion in aged mice improves insulin sensitivity and metabolic capacity of adipose tissue. These data reveal that inhibiting Nlrp3-dependent B cell accumulation can be targeted to reverse metabolic impairment in aging adipose tissue.

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CAZORLA, DALMIRO, and Maritza Alarcón. "PRESENCIA DE LA ARAÑA DE SEDA DORADA Trichonephila clavipes (Linnaeus 1767) (ARANEAE: ARANEIDAE: NEPHILINAE) EN LA SIERRA DE SAN LUIS (ESTADO FALCÓN) Y MÉRIDA (ESTADO MÉRIDA), VENEZUELA." Revista nicaragüense de Entomología 373 (February 26, 2025): 1–26. https://doi.org/10.5281/zenodo.14927736.

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Se documenta la presencia de la especie de “araña de seda dorada” <em>Trichonephila clavipes </em>(Linnaeus 1767)<strong> </strong>(Araneae: Araneidae: Nephilinae) en localidades de dos regiones geográficas de Venezuela, incluyendo nor-occidental (El Mamón, Sierra de San Luis, estado Falcón) y andina (Parroquia Osuna Rodríguez y Parroquia Juan Rodríguez Suárez, ciudad de Mérida, estado Mérida).

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Ali, Saima, Muhammad Rashid Khan, Sayed Afzal Shah, et al. "Protective aptitude of Periploca hydaspidis Falc against CCl4 induced hepatotoxicity in experimental rats." Biomedicine & Pharmacotherapy 105 (September 2018): 1117–32. http://dx.doi.org/10.1016/j.biopha.2018.06.039.

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CAZORLA, DALMIRO, and Maritza Alarcón. "PRESENCIA DE Anochrostomus formosus (Blanchard, 1840) (HETEROPTERA: LYGAEIDAE: LYGAEINAE) EN LA SIERRA DE SAN LUIS, ESTADO FALCÒN, VENEZUELA." Revista nicaragüense de Entomología 336 (April 20, 2024): 1–24. https://doi.org/10.5281/zenodo.11001975.

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Se registra por primera vez la presencia de <em>Anochrostomus</em><em> formosus</em> (Blanchard, 1840) (Heteroptera: Lygaeidae: Lygaeinae) en la población de<strong> </strong>El Mamón, Sierra de San Luis, estado Falcón al nor-occidente de Venezuela. Se capturaron varios especímenes sobre plantas de <em>Malvastrum americanum</em> (L.) Torr. (Malvaceae) (Nuevo registro), <em>Leonotis</em> sp. (Pers.)R. Br. (Lamiaceae) (Nuevo registro), <em>Ipomoea nil</em> (L.) Roth (Convolvulaceae) (Nuevo registro) y otra no identificada.

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Cazorla, Dalmiro, and Pedro Morales-Moreno. "Reporte intradomiciliar de Tribolium confusum du Val, 1863 (Coleoptera: tenebrionidae) en el semiárido urbano del estado Falcón, Venezuela." SABER 31 (March 4, 2019): 21–23. https://doi.org/10.5281/zenodo.5500748.

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<strong>RESUMEN </strong> Se reporta la presencia del insecto-plaga “gorgojo confuso de la harina”<em> Tribolium confusum</em> du Val, 1863 (Coleoptera: Tenebrionidae, Ulominae), capturado dentro de una vivienda del área urbana de zona semiárida del estado Falcón, Venezuela. <strong>ABSTRACT</strong> A report is made of the presence of the insect plague “confused flour beetle”<em> Tribolium confusum</em> du Val, 1863 (Coleoptera: Tenebrionidae, Ulominae), collected into a dwelling of an urban semiarid area from Falcon state, Venezuela.

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Jackson-Jones, Lucy H., and Cécile Bénézech. "FALC stromal cells define a unique immunological niche for the surveillance of serous cavities." Current Opinion in Immunology 64 (June 2020): 42–49. http://dx.doi.org/10.1016/j.coi.2020.03.008.

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Budhy, Theresia Indah, Ira Arundina, Anis Irmawati, et al. "Anticancer activity of Aucklandia costus Falc. terpenes: Targeting MDM2 protein inhibition for therapeutic advancements." Journal of Pharmacy & Pharmacognosy Research 12, no. 4 (2024): 748–58. http://dx.doi.org/10.56499/jppres23.1910_12.4.748.

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Context: Protein 53 (p53) is a well-known tumor suppressor protein, while murine double minute 2 (MDM2) acts as a negative regulator of p53, leading to p53 inactivation and cancer development. Aucklandia costus Falc. or Saussurea lappa contains bioactive compounds, particularly terpenoids, known for their anticancer activity against various cancer cells. Targeting the p53-MDM2 protein interaction and inhibiting MDM2 are crucial strategies in cancer therapy. Aims: To analyze the anticancer properties of A. costus terpenes against MDM2 protein. Methods: The compounds costunolide, dehydrocostus lactone, lappadilactone, and cynaropicrin were docked with MDM2 (PDB ID: 4HG7) using AutoDockTools 1.5.6. Additionally, the physicochemical, pharmacokinetic, and toxicity properties were predicted using pkCSM. Results: Lappadilactone exhibited the highest binding energy value, surpassing both the control and the native ligand. Following lappadilactone, cynaropicrin, costunolide, and dehydrocostus lactone displayed decreasing binding energies. When assessing ADMET properties with pkCSM, all compounds exhibited good permeability, suggesting their ability to penetrate intestinal cell membranes, and showed no signs of hepatotoxicity. Conclusions: Lappadilactone emerges as a promising candidate with high intestinal absorption, distinctive distribution characteristics, and a lack of mutagenic or hepatotoxic effects.

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Bhushan, Anil, Dixhya Rani, Misbah Tabassum, et al. "HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions of Aucklandia costus Falc. and Cytotoxicity Studies against Cancer Cells." Molecules 28, no. 12 (2023): 4815. http://dx.doi.org/10.3390/molecules28124815.

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Aucklandia costus Falc. (Synonym: Saussurea costus (Falc.) Lipsch.) is a perennial herb of the family Asteraceae. The dried rhizome is an essential herb in the traditional systems of medicine in India, China and Tibet. The important pharmacological activities reported for Aucklandia costus are anticancer, hepatoprotective, antiulcer, antimicrobial, antiparasitic, antioxidant, anti-inflammatory and anti-fatigue activities. The objective of this study was the isolation and quantification of four marker compounds in the crude extract and different fractions of A. costus and the evaluation of the anticancer activity of the crude extract and its different fractions. The four marker compounds isolated from A. costus include dehydrocostus lactone, costunolide, syringin and 5-hydroxymethyl-2-furaldehyde. These four compounds were used as standard compounds for quantification. The chromatographic data showed good resolution and excellent linearity (r2 ˃ 0.993). The validation parameters, such as inter- and intraday precision (RSD < 1.96%) and analyte recovery (97.52–110.20%; RSD < 2.00%),revealed the high sensitivity and reliability of the developed HPLC method. The compounds dehydrocostus lactone and costunolide were concentrated in the hexane fraction (222.08 and 65.07 µg/mg, respectively) and chloroform fraction (99.02 and 30.21 µg/mg, respectively), while the n-butanol fraction is a rich source of syringin (37.91 µg/mg) and 5-hydroxymethyl-2-furaldehyde (7.94 µg/mg). Further, the SRB assay was performed for the evaluation of anticancer activity using lung, colon, breast and prostate cancer cell lines. The hexane and chloroform fractions show excellent IC50 values of 3.37 ± 0.14 and 7.527 ± 0.18 µg/mL, respectively, against the prostate cancer cell line (PC-3).

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Wang, Hui, Yujing Zhao, Jialiang Liu, Jiaheng Ma, and Zhiyong Li. "Numerical Simulation of Double-row Piles in Deep Foundation Pit Excavation." Journal of Physics: Conference Series 2736, no. 1 (2024): 012005. http://dx.doi.org/10.1088/1742-6596/2736/1/012005.

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Abstract This paper aims to investigate the stress and deformation characteristics of double-row piles in deep foundation pit excavation by selecting representative strata in the Changchun area. The changes in bending moment, displacement, and earth pressure of double-row piles during the excavation are established using the FALC 3D software. The findings indicate that the deformation of the front pile is larger than that of the back pile, and the earth pressure distribution of the fornt pile deviates from the conventional Rankine earth pressure theory. Moreover, there are noticeable variations in earth pressure at the soil layer interface of the rear pile.

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47

Oneida, F. Jordán ;. Henrry A. Lovera. "Diseño de modelo organizativo participativo para agilizar la gestión de las obras civiles en la alcaldía del municipio Urumaco. Estado Falcón." Observador del Conocimiento men 3 número 3 agosto 2016, ISSN: 2343-6212 (2020): 146–53. https://doi.org/10.5281/zenodo.4274154.

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El desarrollo de la presente investigación propone un modelo organizativo participativo para agilizar la gestión de obras civiles en la alcaldía del municipio Urumaco del estado Falcón. El trabajo se sustentó teóricamente en la descripción de los modelos administrativos propuesto para la administración pública y se seleccionó el Modelo por Objetivo y Resultado, Ossorio (2009), el cual parte de un proceso de planificación estratégica situacional planteado por C. Matus (2002). En cuanto a la metodología, fue de campo, modalidad proyecto factible, tomando como muestra 14 funcionarios de la alcaldía y 16 miembros de los consejos comunales, a los cuales se le aplicó un cuestionario contentivo de 12 preguntas. El principal resultado al que se llegó establece que existe un gran vacío pues no se cuenta con un modelo participativo para garantizar la inserción de los consejos comunales en la planificación, formulación de proyectos, ejecución y control de obras civiles. Como conclusión se expuso que los elementos que posee un modelo organizativo participativo para agilizar la gestión de obras civiles en la alcaldía del municipio Urumaco del estado Falcón, se orientan principalmente en una serie de técnicas y herramientas que permiten darle forma y respuesta a las ideas y necesidades que se plantean continuamente dentro cualquier sector o actividad que se desarrolle en el contexto de una comunidad, parroquia, barrio u urbanización.

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48

Cazorla, Dalmiro, and Blanco Elsa Nieves. "Variación morfométrica altitudinal en hembras de Pintomyia (Pifanomyia) evansi (Núñez-Tovar, 1924) (Diptera: Psychodidae, Phlebotominae) en el estado Falcón, Venezuela." SABER 31 (March 4, 2019): 33–38. https://doi.org/10.5281/zenodo.5500762.

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<strong>RESUMEN</strong> Se ha realizado un estudio para determinar la influencia de la altura sobre las dimensiones de 30 caracteres morfológicos de ejemplares hembras de <em>Pintomyia </em>(<em>Pifanomyia</em>)<em> evansi</em> (Núñez-Tovar, 1924) (Diptera: Psychodidae, Phlebotominae). Los ejemplares fueron capturados en 10 localidades del estado Falcón, Venezuela, ubicadas en un intervalo altitudinal entre 66 y 792 m.s.n.m. Se encontró que los ejemplares de <em>Pi. </em>(<em>Pif.</em>)<em> evansi</em> recolectados en las altitudes más elevadas (462-792 m.s.n.m.) presentaron dimensiones significativamente mayores en 23 caracteres morfológicos, tal como lo establece la regla eco-geográfica de Bergmann. Se discute las posibles implicaciones de los resultados obtenidos en el contexto del estatus taxonómico de <em>Pi. </em>(<em>Pif.</em>)<em> evansi</em> en el estado Falcón. <strong>ABSTRACT</strong> A study was carried out to determine the influence of altitude on the dimensions of 30 morphological characters of female specimens of <em>Pintomyia </em>(<em>Pifanomyia</em>)<em> evansi</em> (Nuñez-Tovar, 1924) (Diptera: Psychoddae, Phlebotominae). The specimens were captured in 10 places of Falcon state, Venezuela, located in an altitudinal range between 66 and 792 m. The specimens of <em>Pi. </em>(<em>Pif.</em>)<em> evansi</em> collected at the higher locations (462-792 m) showed significantly higher sizes in 23 morphological characters, as states Bergmann’ eco-geographic rule. The possible implications of the results obtained in the context of the taxonomic status of <em>Pi. </em>(<em>Pif.</em>)<em> evansi</em> in Falcon state, are discussed.

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Dominguez, Joseph R., Jiseon Kim, Seung Hyeon Kim, et al. "Abstract 6144: Peritoneal and omental macrophages provide anti-tumor immunity in an ovarian cancer model." Cancer Research 85, no. 8_Supplement_1 (2025): 6144. https://doi.org/10.1158/1538-7445.am2025-6144.

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Abstract The omentum is a visceral adipose tissue that contains fat-associated lymphoid clusters (FALC) to aid in peritoneal immunity. These clusters consist of large aggregates of B cells, T cells, dendritic cells, macrophages, and innate lymphoid cells that participate in the clearance of pathogens. Tissue-resident macrophages (TRM) are immune cells found in every tissue and their function is influenced by the local tissue microenvironment. TRM can be defined by their origins, consisting of subsets maintained either by embryonic precursors or by bone-marrow progenitors. A recent study found embryonically derived TRM express at least one marker amongst Tim4, LYVE1, FOLR2 while bone marrow derived macrophages maintain CCR2 expression. Previous publications have shown the existence of LYVE1+ macrophages surrounding each cluster, here we study an unexamined subset of FALC-associated macrophages that are imbedded within the lymphoid structures. Using confocal imaging, flow cytometry analysis with reporter/ conditional knock-out mice, we have characterized this TRM subset as CX3CR1+ LYVE1lo/- Tim4- and CCR2 dependent. Through Wt1-driven csf1 deletion, we depleted peritoneal and omental-resident (ORM) and found increased ID8 tumor cells in comparison to littermate controls. Lastly, promotion of CX3CR1+ ORM and reduction of LYVE1+ Tim4- ORM led to reduced tumor growth in the omentum in early-stage tumor challenge. Citation Format: Joseph R. Dominguez, Jiseon Kim, Seung Hyeon Kim, Yeonwoo Choi, Soroush Tahmasebi, Brahm H. Segal, Burkhard Ludewig, Ki-Wook Kim. Peritoneal and omental macrophages provide anti-tumor immunity in an ovarian cancer model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 6144.

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50

Oneida, F. Jordán, and A. Lovera Henrry. "Diseño de modelo organizativo participativo para agilizar la gestión de las obras civiles en la alcaldía del municipio Urumaco. Estado Falcón." Observador del Conocimiento Vol. 3 Nº 3 agosto 2016, no. 2343-6212 (2022): 146–53. https://doi.org/10.5281/zenodo.6337855.

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Abstract:

El desarrollo de la presente investigación propone un modelo organizativo participativo para agilizar la gestión de obras civiles en la alcaldía del municipio Urumaco del estado Falcón. El trabajo se sustentó teóricamente en la descripción de los modelos administrativos propuesto para la administración pública y se seleccionó el Modelo por Objetivo y Resultado, Ossorio (2009), el cual parte de un proceso de planificación estratégica situacional planteado por C. Matus (2002). En cuanto a la metodología, fue de campo, modalidad proyecto factible, tomando como muestra 14 funcionarios de la alcaldía y 16 miembros de los consejos comunales, a los cuales se le aplicó un cuestionario contentivo de 12 preguntas. El principal resultado al que se llegó establece que existe un gran vacío pues no se cuenta con un modelo participativo para garantizar la inserción de los consejos comunales en la planificación, formulación de proyectos, ejecución y control de obras civiles. Como conclusión se expuso que los elementos que posee un modelo organizativo participativo para agilizar la gestión de obras civiles en la alcaldía del municipio Urumaco del estado Falcón, se orientan principalmente en una serie de técnicas y herramientas que permiten darle forma y respuesta a las ideas y necesidades que se plantean continuamente dentro cualquier sector o actividad que se desarrolle en el contexto de una comunidad, parroquia, barrio u urbanización.

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