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Journal articles on the topic 'Falcarinol'

Author: Grafiati

Published: 24 April 2022

Last updated: 25 July 2025

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1

D., Bonilla Rodríguez, Sánchez Vázquez M., and Rosete Luna S. "Evaluación de las propiedades antioxidantes del falcarinol y sus derivados por métodos computacionales." Coloquio de Investigación Multidisciplinaria 7, no. 1 (2019): 1460–65. https://doi.org/10.5281/zenodo.4278265.

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El falcarinol y sus derivados como el falcarindiol, panaxidol y falcarinon son poliacetilenos producidos por plantas superiores de las familias de las Apiaceae, Araliaceae y Asteraceae, estos compuestos han sido estudiados para determinar su bioactividad y se encuentran plenamente caracterizados. En este trabajo se realizó un estudio teórico de las propiedades antioxidantes del falcarinol y sus derivados con la finalidad de estudiar sus propiedades electrónicas y su capacidad de reaccionar con los radicales libres a partir del mecanismo de transferencia del átomo de

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2

Deding, Ulrik, Bettina Hjelm Clausen, Issam Al-Najami, Gunnar Baatrup, Boye Lagerbon Jensen, and Morten Kobaek-Larsen. "Effect of Oral Intake of Carrot Juice on Cyclooxygenases and Cytokines in Healthy Human Blood Stimulated by Lipopolysaccharide." Nutrients 15, no. 3 (2023): 632. http://dx.doi.org/10.3390/nu15030632.

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In vitro studies and animal studies have shown that chemical compounds contained in carrots, such as falcarinol and falcarindiol, can prevent inflammation. The present study was designed to test whether the oral intake of carrot juice containing falcarinol and falcarindiol affects the activity of cyclooxygenase (COX) enzymes and the secretion of inflammatory cytokines in human blood. Carrot juice (500 mL) was administered orally to healthy volunteers, and blood samples were drawn before and 1 h after juice intake at the time point when peak concentrations of falcarinol and falcariondiol have b

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3

Kobaek-Larsen, Morten, Rime B. El-Houri, Lars P. Christensen, Issam Al-Najami, Xavier Fretté, and Gunnar Baatrup. "Dietary polyacetylenes, falcarinol and falcarindiol, isolated from carrots prevents the formation of neoplastic lesions in the colon of azoxymethane-induced rats." Food & Function 8, no. 3 (2017): 964–74. http://dx.doi.org/10.1039/c7fo00110j.

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4

El-Houri, Rime B., Dorota Kotowska, Kathrine B. Christensen, et al. "Polyacetylenes from carrots (Daucus carota) improve glucose uptake in vitro in adipocytes and myotubes." Food & Function 6, no. 7 (2015): 2135–44. http://dx.doi.org/10.1039/c5fo00223k.

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5

Batista, Ulisses G., and Verna J. Higgins. "Accumulation of phytoalexins in the compatible interaction between Cladosporium fulvum and tomato in relation to colonization." Canadian Journal of Botany 69, no. 4 (1991): 822–30. http://dx.doi.org/10.1139/b91-107.

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The production and distribution of the phytoalexin falcarindiol in tomato foliage infected with leaf mold was examined to determine how the fungus Cladosporium fulvum is able to colonize and sporulate in an apparently antifungal environment. In a compatible interaction (cv. Potentate – C. fulvum race 2.3), by 12 and 15 days after inoculation, solvent-extractable falcarindiol and two other phytoalexins from tomato, compound 2 (probably falcarinol) and compound 3 (unidentified), reached concentrations considerably in excess of ED50 values for inhibition of the fungus. In contrast, intercellular

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6

Rollinger, Judith M., Christian Zidorn, Michael J. Dobner, Ernst P. Ellmerer, and Hermann Stuppner. "Lignans, Phenylpropanoids and Polyacetylenes from Chaerophyllum aureum L. (Apiaceae)." Zeitschrift für Naturforschung C 58, no. 7-8 (2003): 553–57. http://dx.doi.org/10.1515/znc-2003-7-818.

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Abstract Sub-aerial parts of Chaerophyllum aureum L. yielded two polyacetylenes, falcarinol (1), falcarindiol (2), three lignans, namely nemerosin (3), deoxypodorhizone (4), deoxypodo-phyllotoxin (5), two phenylpropanoids, 1′-hydroxymyristicin (6) and its angeloyl ester (7). Compounds 6 and 7 were isolated for the first time from plant material and their structures were elucidated by means of extensive 1- and 2-dimensional NMR spectroscopy and high resolution mass spectrometry. In bioautographic tests on TLC plates the dichloromethane extract showed a significant antimicrobial activity. Falcar

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7

Bruhn, Gabriele, Holger Faasch, Holger Hahna, Björn M. Hausen, Johann Bröhan, and Wilfried A. König. "Natürliche Allergene, I. Das Auftreten von Falcarinol und Didehydrofalcarinol in Efeu (Hedera helix L.) / Natural Allergenes. I. The Occurrence of Falcarinol and Didehydrofalcarinol in Ivy (Hedera helix L .)." Zeitschrift für Naturforschung B 42, no. 10 (1987): 1328–32. http://dx.doi.org/10.1515/znb-1987-1018.

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Abstract From common ivy Hedera helix, subsp. helix and from Hedera helix, subsp. canariensis the highly unsaturated CI7-alcohols falcarinol (1) and the so far unknown didehydrofalcarinol (2) [(3R)-heptadeca-1,9(Z),11(Z),16-tetraene-4,6-diyne-3-ol] was isolated and its structures identified by mass spectrometry and NMR. The (R)-configuration of falcarinol and didehydrofalcarinol was determined after catalytic hydrogenation to 3-heptadecanol by enantioselective capillary gas chromatography. Falcarinol and didehydrofalcarinol effect sensibilization and allergic skin reactions in minute concentr

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8

Bernart, Matthew W., John H. Cardellina, Michael S. Balaschak, Mark R. Alexander, Robert H. Shoemaker, and Michael R. Boyd. "Cytotoxic Falcarinol Oxylipins fromDendropanaxarboreus." Journal of Natural Products 59, no. 8 (1996): 748–53. http://dx.doi.org/10.1021/np960224o.

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9

Padalia, Rajendra C., Ram S. Verma, Amit Chauhan, Chandan S. Chanotiya, and Anju Yadav. "Variation in the Volatile Constituents of Different Plant Parts of Ligusticopsis wallichiana from Western Himalaya, India." Natural Product Communications 7, no. 8 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700828.

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The essential oil composition of the leaves, stem, flowers and roots of Ligusticopsis wallichiana (DC.) Pimenov & Kljuykov were analyzed by GC-FID and GC-MS methods. Forty-five constituents, forming 93.2%–97.8% of the oil compositions, were dominated by acetylenic (31.5%–92.8%) compounds and sesquiterpenoids (0.3%–44.4%). The leaf essential oil was mainly composed 3,5-nonadiyne (35.8%), β-selinene (20.9%), α-funebrene (10.1%) and ( Z)-falcarinol (6.1%). The stem oil was dominated by acetylenic compounds (73.8%) represented by 3,5-nonadiyne (67.8%) and ( Z)-falcarinol (5.7%). On the contrar

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10

Heydenreuter, Wolfgang, Elena Kunold, and Stephan A. Sieber. "Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site." Chemical Communications 51, no. 87 (2015): 15784–87. http://dx.doi.org/10.1039/c5cc06424d.

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11

Shi, Shengli, Xinsha Zhang, Xianbin Liu, et al. "GC-MS Analysis of the Essential Oil from Seseli mairei H. Wolff (Apiaceae) Roots and Their Nematicidal Activity." Molecules 28, no. 5 (2023): 2205. http://dx.doi.org/10.3390/molecules28052205.

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The essential oil (EO) was extracted from aerial parts with insecticidal and fungicidal activity. Herein, the hydro-distilled essential oils of Seseli mairei H. Wolff roots were determined by GC-MS. A total of 37 components were identified, (E)-beta-caryophyllene (10.49%), β-geranylgeranyl (6.64%), (E)-2-decenal (6.17%) and germacrene-D (4.28%). The essential oil of Seseli mairei H. Wolff had nematicidal toxicity against Bursaphelenchus xylophilus with a LC50 value of 53.45 μg/mL. The subsequent bioassay-guided investigation led to the isolation of three active constituents: falcarinol, (E)-2-

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12

Kjellenberg, Lars, Eva Johansson, Karl-Erik Gustavsson, Artur Granstedt, and Marie E. Olsson. "Influence of organic manures on carrot (Daucus carota L.) crops grown in a long-term field experiment in Sweden." Renewable Agriculture and Food Systems 31, no. 3 (2015): 258–68. http://dx.doi.org/10.1017/s1742170515000174.

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AbstractThis study evaluated the effects of organic agriculture manuring systems on carrot (Daucus carota) root morphology and sugar and polyacetylene content. Carrots were harvested three times per season 2006–2007 in a long-term field experiment at Skilleby research farm, Sweden. The effects of pelleted chicken manure, fresh farmyard manure and composted farmyard manure (COM) were compared against control plots left unmanured since the field experiment started in 1991. The carrots were analyzed for root size, root shape, amount of soluble sugars and amount of falcarinol-type polyacetylenes.

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13

Young, Jette F., Lars P. Christensen, Peter K. Theil, and Niels Oksbjerg. "The Polyacetylenes Falcarinol and Falcarindiol Affect Stress Responses in Myotube Cultures in a Biphasic Manner." Dose-Response 6, no. 3 (2008): dose—response.0. http://dx.doi.org/10.2203/dose-response.08-008.young.

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14

Jakubczyk, Katarzyna, Katarzyna Janda, Daniel Styburski, and Agnieszka Łukomska. "Goutweed (Aegopodium podagraria L.) – botanical characteristics and prohealthy properties*." Postępy Higieny i Medycyny Doświadczalnej 74 (February 19, 2020): 28–35. http://dx.doi.org/10.5604/01.3001.0013.8551.

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Goutweed (Aegopodium podagraria L.) is a common plant in the Apiaceae family. It occurs in Europe, North America and Asia. In folk medicine, mainly the leaves of goutweed were used to treat gout, inflammatory states in kidneys and bladder and to facilitate wound healing. Chemical composition of goutweed has not been entirely determined, however, it is known that the main group of compounds are polyacetylenes (falcarinol and falcarindiol). Moreover, other compounds were isolated from this plant, such as essential oils from the group of mono- and sesquiterpenes, as well as coumarins and polyphen

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15

Machado, S., E. Silva, and A. Massa. "Occupational allergic contact dermatitis from falcarinol." Contact Dermatitis 47, no. 2 (2002): 109–25. http://dx.doi.org/10.1034/j.1600-0536.2002.470210_5.x.

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16

McLaughlin, Noel P., Eibhlín Butler, Paul Evans, Nigel P. Brunton, Anastasios Koidis, and Dilip K. Rai. "A short synthesis of (+) and (−)-falcarinol." Tetrahedron 66, no. 51 (2010): 9681–87. http://dx.doi.org/10.1016/j.tet.2010.10.049.

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17

Nguyen, Thi Hoang Anh, Thi Ngan Dang, Doan Manh Dung, et al. "Non-hydrophilic components from roots of Vietnamese ginseng (Panax vietnamensis Ha & Grushv.)." Hue University Journal of Science: Natural Science 133, no. 1D (2024): 19–25. https://doi.org/10.26459/hueunijns.v133i1d.7308.

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Vietnamese ginseng is a precious medicinal herb and contains various ginsenosides as the main components. We studied the less polar constituents of the title ginseng and isolated falcarinol (1) and 20S-protopanaxatriol (4) for the first time, along with two common phytosterols: β-sitosterol (2) and daucosterol (3). Their structures were elucidated with nuclear magnetic resonance (NMR) and mass spectrometry (MS) spectra and compared with the literature data. Falcarinol was obtained from the non-polar portion of the crude residue, with a high content. The occurrence of 20S-protopanaxatriol becom

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18

Kramer, Maike, Andrea Mühleis, Jürgen Conrad, et al. "Quantifi cation of Polyacetylenes in Apiaceous Plants by High-Performance Liquid Chromatography Coupled with Diode Array Detection." Zeitschrift für Naturforschung C 66, no. 7-8 (2011): 319–27. http://dx.doi.org/10.1515/znc-2011-7-801.

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Polyacetylenes are known for their biofunctional properties in a wide range of organisms. In the present study, the most frequently occurring polyacetylenes, i.e. falcarinol, falcarindiol, and falcarindiol-3-acetate, were determined in six genera of the Apiaceae family. For this purpose, a straightforward and reliable method for the screening and quantification of the polyacetylenes using high-performance liquid chromatography coupled with diode array and mass spectrometric detection without tedious sample clean-up has been developed. Peak assignment was based on retention times, UV spectra, a

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19

Merad, Nadjiya, Vanessa Andreu, Slimane Chaib, et al. "Essential Oils from Two Apiaceae Species as Potential Agents in Organic Crops Protection." Antibiotics 10, no. 6 (2021): 636. http://dx.doi.org/10.3390/antibiotics10060636.

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Chemical composition and herbicidal, antifungal, antibacterial and molluscicidal activities of essential oils from Choukzerk, Eryngium triquetrum, and Alexander, Smyrnium olusatrum, from western Algeria were characterized. Capillary GC-FID and GC/MS were used to investigate chemical composition of both essential oils, and the antifungal, antibacterial, molluscicidal and herbicidal activities were determined by % inhibition. Collective essential oil of E. triquetrum was dominated by falcarinol (74.8%) and octane (5.6%). The collective essential oil of S. olusatrum was dominated by furanoeremoph

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20

Boll, Per M., and Lene Hansen. "On the presence of falcarinol in araliaceae." Phytochemistry 26, no. 11 (1987): 2955–56. http://dx.doi.org/10.1016/s0031-9422(00)84569-0.

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21

Czyzewska, Marta Magdalena, Lukasz Chrobok, Alan Kania, et al. "Dietary Acetylenic Oxylipin Falcarinol Differentially Modulates GABAAReceptors." Journal of Natural Products 77, no. 12 (2014): 2671–77. http://dx.doi.org/10.1021/np500615j.

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22

Marčetić, Mirjana, Dragana Božić, Marina Milenković, Branislava Lakušić, and Nada Kovačević. "Chemical Composition and Antimicrobial Activity of Essential Oil of Different Parts of Seseli rigidum." Natural Product Communications 7, no. 8 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700832.

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The chemical composition and antimicrobial activity of the essential oil of the Balkan endemic species Seseli rigidum Waldst. & Kit. (Apiaceae) was investigated. The monoterpene α-pinene was predominant in the volatile oil from aerial parts (57.4%) and fruit (23.3%). In the essential oil of the aerial parts limonene (6.7%), camphene (5.8%) and sabinene (5.5%) were also present in high amounts, and in the fruit oil, β-phellandrene (17.4%) and sabinene (12.9%). On the contrary, the root essential oil was composed almost entirely of the polyacetylene falcarinol (88.8%). The antimicrobial acti

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23

Hansen, Lene, Ole Hammershøy, and Per M. Boll. "Allergic contact dermatitis from falcarinol isolated fromSchefflera arboricola." Contact Dermatitis 14, no. 2 (1986): 91–93. http://dx.doi.org/10.1111/j.1600-0536.1986.tb01167.x.

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24

Bakytzhanova, M. S., K. H. Makhmudova, A. U. Tuyakbayeva, N. A. Utarbayeva, A. A. Bitkeyeva, and T. Atici. "Phytochemical and elemental composition of the Linaria cretacea Fisch ex Spreng (Plantaginaceae)." BULLETIN OF THE L.N. GUMILYOV EURASIAN NATIONAL UNIVERSITY. BIOSCIENCE SERIES 151, no. 2 (2025): 169–83. https://doi.org/10.32523/2616-7034-2025-151-2-169-183.

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The article presents the results of a phytochemical study of a rare species of the Republic of Kazakhstan Linaria cretacea Fisch ex Spreng. Specific biologically active compounds contained in the inflorescences, roots, and leaves of plants have demonstrated their pharmacological properties and biological activity, confirming that various phytochemical groups and individual compounds have beneficial effects. Of the total number of organic compounds detected in ethanol extracts, falcarinol (with a relative content of 16,51%) and thymol (with a relative content of 0,57%) in L. cretacea were ident

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25

Getzinger. "Falcarinol Content in Carrot Genotypes Determined by LC-MS." Scientia Pharmaceutica 77, no. 1 (2009): 193. http://dx.doi.org/10.3797/scipharm.oephg.21.sl-26.

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26

Jodynis-Liebert, Jadwiga, and Małgorzata Kujawska. "Biphasic Dose-Response Induced by Phytochemicals: Experimental Evidence." Journal of Clinical Medicine 9, no. 3 (2020): 718. http://dx.doi.org/10.3390/jcm9030718.

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Many phytochemicals demonstrate nonmonotonic dose/concentration-response termed biphasic dose-response and are considered to be hormetic compounds, i.e., they induce biologically opposite effects at different doses. In numerous articles the hormetic nature of phytochemicals is declared, however, no experimental evidence is provided. Our aim was to present the overview of the reports in which phytochemical-induced biphasic dose-response is experimentally proven. Hence, we included in the current review only articles in which the reversal of response between low and high doses/concentrations of

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27

Kobaek-Larsen, Morten, Ulrik Deding, Issam Al-Najami, Bettina Hjelm Clausen, and Lars Porskjær Christensen. "Carrot Juice Intake Affects the Cytokine and Chemokine Response in Human Blood after Ex Vivo Lipopolysaccharide-Induced Inflammation." Nutrients 15, no. 23 (2023): 5002. http://dx.doi.org/10.3390/nu15235002.

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In vitro and animal studies have shown that carrot juice containing bioactive natural products, such as falcarinol (FaOH) and falcarindiol (FaDOH), can affect inflammation. The present study was designed to test whether oral intake of carrot juice containing the bioactive acetylenic oxylipins FaOH and FaDOH affects mediators of acute inflammation or the innate immune response in human blood. Carrot juice (500 mL) was administered orally to healthy volunteers, and blood samples were drawn before and 1 h after juice intake. Next, the blood samples were split in two, and one sample was stimulated

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28

Hansen, Lene, and Per M. Boll. "The polyacetylenic falcarinol as the major allergen in schefflera arboricola." Phytochemistry 25, no. 2 (1986): 529–30. http://dx.doi.org/10.1016/s0031-9422(00)85517-x.

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29

Rawson, Ashish, Nigel P. Brunton, Dilip K. Rai, Padraig McLoughlin, Brijesh K. Tiwari, and Maria G. Tuohy. "Stability of falcarinol type polyacetylenes during processing of Apiaceae vegetables." Trends in Food Science & Technology 30, no. 2 (2013): 133–41. http://dx.doi.org/10.1016/j.tifs.2013.01.002.

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30

Cheung, Susan S. C., David Hasman, Djamel Khelifi, Joseph Tai, Richard W. Smith, and Garth L. Warnock. "Devil’s Club Falcarinol-Type Polyacetylenes Inhibit Pancreatic Cancer Cell Proliferation." Nutrition and Cancer 71, no. 2 (2019): 301–11. http://dx.doi.org/10.1080/01635581.2018.1559931.

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31

Kim, Seong-Ju, and Kyu-Seob Chang. "Optimization of the Falcarinol Extraction Conditions from Acanthopanax senticosus Using Supercritical Fluid Carbon Dioxide." Food Engineering Progress 9, no. 1 (2005): 52–58. http://dx.doi.org/10.13050/foodengprog.2005.9.1.52.

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32

Deding, Ulrik, Gunnar Baatrup, Lasse Kaalby, and Morten Kobaek-Larsen. "Carrot Intake and Risk of Developing Cancer: A Prospective Cohort Study." Nutrients 15, no. 3 (2023): 678. http://dx.doi.org/10.3390/nu15030678.

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A prospectively followed Danish cohort of 55,756 citizens with an observation time upwards of 25 years was investigated for association between eating raw carrots on a regular basis and developing various adenocarcinoma-dominant cancers and leukemia. Mean age at inclusion was 56.2 years (SD 4.4 years), and 52% were females. A dose-dependent reduction in incidence was seen for cancer of the lung (HR 0.76, CI95% 0.66; 0.87) and pancreas (HR 0.79, CI95% 0.61; 1.03), as well as leukemia (HR 0.91, CI95% 0.68; 1.21). Only for lung cancer was the association significant. In the case of pancreatic can

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33

Kobaek-Larsen, Morten, Gunnar Baatrup, Martine KhataeiNotabi, et al. "Dietary Polyacetylenic Oxylipins Falcarinol and Falcarindiol Prevent Inflammation and Colorectal Neoplastic Transformation: A Mechanistic and Dose-Response Study in A Rat Model." Nutrients 11, no. 9 (2019): 2223. http://dx.doi.org/10.3390/nu11092223.

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Falcarinol (FaOH) and falcarindiol (FaDOH) are cytotoxic and anti-inflammatory polyacetylenic oxylipins, which are commonly found in the carrot family (Apiaceae). FaOH and FaDOH have previously demonstrated a chemopreventive effect on precursor lesions of colorectal cancer (CRC) in azoxymethane (AOM)-induced rats. The purpose of the present study was to elucidate possible mechanisms of action for the preventive effect of FaOH and FaDOH on colorectal precancerous lesions and to determine how this effect was dependent on dose. Gene expression studies performed by RT-qPCR of selected cancer bioma

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Shree N., Lakshmi, and Dr Suchi Modi. "Chemoprofiling of Patchouli and Galangal for Eco-Conscious Skincare Innovation: A Path toward Circular Utilization." International Journal of Environmental Sciences 11, no. 5s (2025): 170–81. https://doi.org/10.64252/pz66wz26.

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This study investigates sustainable methods for utilizing two aromatic plants, Patchouli (Pogostemon cablin) and Galangal (Alpinia galanga), through chemical profiling conducted with gas chromatography-mass–mass spectrometry (GC-MS). The goal was to identify underreported or unique phytocompounds with potential use in eco-conscious skincare formulations. Among the notable findings were azulene, falcarinol, and 1′-acetoxychavicol acetate—compounds seldom detected in these plants but recognized for their antioxidant, calming, and skin-regenerative properties. The approach followed green chemistr

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35

Zheng, Guangrong, Wei Lu, Haji A. Aisa, and Junchao Cai. "Absolute configuration of falcarinol, a potent antitumor agent commonly occurring in plants." Tetrahedron Letters 40, no. 11 (1999): 2181–82. http://dx.doi.org/10.1016/s0040-4039(99)00224-5.

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36

Li, Yang, Wan-Li Tan, Kai Guo, et al. "Synthesis and Biological Evaluation of Falcarinol-Type Analogues as Potential Calcium Channel Blockers." Journal of Natural Products 84, no. 8 (2021): 2138–48. http://dx.doi.org/10.1021/acs.jnatprod.1c00136.

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37

Young, Jette F., Susan J. Duthie, Lesley Milne, Lars P. Christensen, Garry G. Duthie, and Charles S. Bestwick. "Biphasic Effect of Falcarinol on CaCo-2 Cell Proliferation, DNA Damage, and Apoptosis." Journal of Agricultural and Food Chemistry 55, no. 3 (2007): 618–23. http://dx.doi.org/10.1021/jf0616154.

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38

Purup, Stig, Eric Larsen, and Lars P. Christensen. "Differential Effects of Falcarinol and Related Aliphatic C17-Polyacetylenes on Intestinal Cell Proliferation." Journal of Agricultural and Food Chemistry 57, no. 18 (2009): 8290–96. http://dx.doi.org/10.1021/jf901503a.

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39

Avalos, Javjer, Gary P. Fontan, and Eloy Rodriguez. "Simultaneous HPLC Quantification of Two Dermatotoxins, 5-Methoxypsoralen and Falcarinol, in Healthy Celery." Journal of Liquid Chromatography 18, no. 10 (1995): 2069–76. http://dx.doi.org/10.1080/10826079508013961.

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40

Deding, Ulrik, Gunnar Baatrup, Lars Porskjær Christensen, and Morten Kobaek-Larsen. "Carrot Intake and Risk of Colorectal Cancer: A Prospective Cohort Study of 57,053 Danes." Nutrients 12, no. 2 (2020): 332. http://dx.doi.org/10.3390/nu12020332.

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Carrots are consumed worldwide. Several meta-analysis studies on carrot consumption have indicated that carrots play a central role as a protecting vegetable against development of different types of cancers. A cancer-preventive role of carrots is plausible because they are the main dietary source of the bioactive polyacetylenic oxylipins falcarinol (FaOH) and falcarindiol (FaDOH), which have shown anti-proliferative and anti-inflammatory activity in numerous in vitro studies. In addition, purified FaOH and FaDOH have, in recent studies in colorectal cancer (CRC)-primed rats, demonstrated an a

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41

Hausen, B. M., J. Bröhas, W. A. König, H. Faasch, H. Hahn, and G. Bruhn. "Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helixL.)." Contact Dermatitis 17, no. 1 (1987): 1–9. http://dx.doi.org/10.1111/j.1600-0536.1987.tb02634.x.

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42

Pferschy-Wenzig, Eva-Maria, Verena Getzinger, Olaf Kunert, Karin Woelkart, Johann Zahrl, and Rudolf Bauer. "Determination of falcarinol in carrot (Daucus carota L.) genotypes using liquid chromatography/mass spectrometry." Food Chemistry 114, no. 3 (2009): 1083–90. http://dx.doi.org/10.1016/j.foodchem.2008.10.042.

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Zheng, Guangrong, Wei Lu, Haji A. Aisa, and Junchao Cai. "ChemInform Abstract: Absolute Configuration of Falcarinol, a Potent Antitumor Agent Commonly Occurring in Plants." ChemInform 30, no. 25 (2010): no. http://dx.doi.org/10.1002/chin.199925224.

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Jakubczyk, Karolina, Agnieszka Łukomska, Sylwester Czaplicki, et al. "Bioactive Compounds in Aegopodium podagraria Leaf Extracts and Their Effects against Fluoride-Modulated Oxidative Stress in the THP-1 Cell Line." Pharmaceuticals 14, no. 12 (2021): 1334. http://dx.doi.org/10.3390/ph14121334.

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Aegopodium podagraria L. (goutweed), a member of the Apiaceae family, is a common perennial plant found all around the world that has been used in folk medicine since antiquity. Goutweed leaves contain polyacetylenes, essential oils, mono- and sesquiterpenes, vitamins, macro- and microelements, and phenolic compounds. In spite of its many health-promoting properties, including antioxidant effects, the plant has not been thoroughly studied. The aim of this study was to investigate the antioxidant properties of different goutweed leaf extracts and their effects on the THP-1 cell line, and also t

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Corell, Mireia, Emile Sheehy, Paul Evans, Nigel Brunton, and Juan Valverde. "Absolute Configuration of Falcarinol (9Z-heptadeca-1,9-diene-4,6-diyn-3-ol) from Pastinaca Sativa." Natural Product Communications 8, no. 8 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800824.

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Falcarinol (9 Z-heptadeca-1,9-diene-4,6-diyn-3-ol; (1) is a polyacetylene commonly found in several plant families. The absolute configuration of naturally occurring 1 is not clear and contradictory results have been reported in the literature. Determination of the absolute configuration of 1 from Pastinaca sativa L. was carried out. Isolation of 95% pure 1 was performed via successive fractionation and preparative-HPLC. A racemic mixture comprised of 3 R-1 and 3 S-1 was synthesized in order to confirm the absolute configuration of the isolated natural product using chiral HPLC. Based on a com

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Tan, Kee W., Daniel P. Killeen, Yan Li, James W. Paxton, Nigel P. Birch, and Arjan Scheepens. "Dietary polyacetylenes of the falcarinol type are inhibitors of breast cancer resistance protein (BCRP/ABCG2)." European Journal of Pharmacology 723 (January 2014): 346–52. http://dx.doi.org/10.1016/j.ejphar.2013.11.005.

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Leonti, Marco, Laura Casu, Stefan Raduner, et al. "Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin." Biochemical Pharmacology 79, no. 12 (2010): 1815–26. http://dx.doi.org/10.1016/j.bcp.2010.02.015.

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Joshi, Rajesh K., and Vijaylaxmi Badakar. "Chemical Composition and in vitro Antimicrobial Activity of the Essential Oil of the Flowers of Tridax procumbens." Natural Product Communications 7, no. 7 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700736.

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The essential oil of the flowers of Tridax procumbens L. was obtained by hydro-distillation and analyzed by gas chromatography equipped with a flame ionization detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC/MS). Twenty-six compounds were identified, which comprised 90.6% of the total constituents. The most abundant compound was ( Z)-falcarinol (25.9%), followed by α-selinene (15.3%), limonene (8.3%) and zerumbone (4.3%). Antimicrobial activity was tested against six Gram-positive and eight Gram-negative bacteria, and three fungi. The oil was active against the test

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Jakobsen, Ulla, Morten Kobæk-Larsen, Karoline D. Kjøller, Steen Antonsen, Gunnar Baatrup, and Morten B. Trelle. "Quantification of the anti-neoplastic polyacetylene falcarinol from carrots in human serum by LC-MS/MS." Journal of Chromatography B 1210 (November 2022): 123440. http://dx.doi.org/10.1016/j.jchromb.2022.123440.

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Stamenković, Jelena G., Gordana S. Stojanović, Ivana R. Radojković, Goran M. Petrović, and Bojan K. Zlatković. "Chemical Composition of the Essential Oil from Chaerophyllum Temulum (Apiaceae)." Natural Product Communications 10, no. 8 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000832.

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The present study reports the chemical composition on the essential oil obtained from fresh roots, stems, inflorescences and fruits of Chaerophyllum temulum. In all samples, except the roots, the most dominant components were sesquiterpene hydrocarbons. ( Z)-Falcarinol was the principal constituent of the root essential oils (61.7% at the flowering stage and 62.3% at the fruiting stage). The blossom oil was dominated by ( Z,E)-α-farnesene (23.4%), ( E)-β-farnesene (9.0%) and germacrene D-4-ol (9%), whereas the oil from the fruit had germacrene D-4-ol (27.6%) as its main compound, accompanied b

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