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1

Yang, Chen, and Peter A. Humphrey. "False-Negative Histopathologic Diagnosis of Prostatic Adenocarcinoma." Archives of Pathology & Laboratory Medicine 144, no. 3 (2019): 326–34. http://dx.doi.org/10.5858/arpa.2019-0456-ra.

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Context.— Histopathologic diagnosis of adenocarcinoma of the prostate is based on light-microscopic examination of hematoxylin-eosin–stained tissue sections. Multiple factors, including preanalytic and analytic elements, affect the ability of the pathologist to accurately diagnose prostatic adenocarcinoma. False-negative diagnosis, that is, failure to diagnose prostatic adenocarcinoma, may have serious clinical consequences. It is important to delineate and understand those factors that may affect and cause histopathologic false-negative diagnoses of prostatic adenocarcinoma. Objectives.— To r
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2

Shanks, Roger D. "Reproductive consequences of deficiency of uridine monophosphate synthase in Holstein cattle." American Journal of Veterinary Research 51, no. 5 (1990): 800–802. http://dx.doi.org/10.2460/ajvr.1990.51.05.800.

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Summary Cattle heterozygous for deficiency of uridine monophosphate synthase required more breeding services per calving when mated to other heterozygotes than did matings of normal cattle. Gestation length, number of breeding services per calving, and days from breeding to pregnancy examination were monitored on 759 complete gestations, 76 false-positive pregnancy diagnoses, 14 false-negative pregnancy diagnoses, and 413 negative pregnancy diagnoses in a dairy herd between 1983 and 1987. For complete gestations, 15 heterozygote × heterozygote matings required 3.13 ± 0.37 breeding services per
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3

Andrews, Gavin. "Case Ascertainment: The Composite International Diagnostic Interview." Australian & New Zealand Journal of Psychiatry 34, no. 1_suppl (2000): A161—A163. http://dx.doi.org/10.1177/000486740003401s24.

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Objective To outline the utility of the Composite International Diagnostic Interview (CIDI) in the diagnosis of psychosis. Method Report current situation. Results The CIDI was designed as a fully structured interview to be used by lay interviewers. It generates false positive diagnoses in community surveys and false negative diagnoses in psychiatric settings. A new psychosis module has been developed to reduce these problems. Conclusions The diagnosis of psychosis by fully structured diagnostic interviews is difficult.
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4

Montague, Drogo K., and Milton M. Lakin. "False Diagnoses of Venous Leak Impotence." Journal of Urology 148, no. 1 (1992): 148–49. http://dx.doi.org/10.1016/s0022-5347(17)36541-2.

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5

Stanley, Michael W. "False-Positive Diagnoses in Exfoliative Cytology." American Journal of Clinical Pathology 104, no. 2 (1995): 117–19. http://dx.doi.org/10.1093/ajcp/104.2.117.

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6

Amrikachi, Mojghan, Ibrahim Ramzy, Sheldon Rubenfeld, and Thomas M. Wheeler. "Accuracy of Fine-Needle Aspiration of Thyroid." Archives of Pathology & Laboratory Medicine 125, no. 4 (2001): 484–88. http://dx.doi.org/10.5858/2001-125-0484-aofnao.

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Abstract Context.—Fine-needle aspiration has become an accepted and cost-effective procedure for rapid diagnosis of thyroid lesions. The routine use of fine-needle aspiration has reduced the rate of unnecessary surgery for thyroid nodules. Objectives.—To determine the accuracy of fine-needle aspiration biopsy diagnosis and to discuss the possible pitfalls. Design, Setting, and Participants.—Reports of 6226 fine-needle aspiration biopsies of the thyroid performed during a period of 16 years (1982–1998) were reviewed. Computerized reports of the fine-needle aspiration biopsies were sent to the p
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7

Renshaw, Andrew A., and Edwin W. Gould. "Reducing False-Negative and False-Positive Diagnoses in Anatomic Pathology Consultation Material." Archives of Pathology & Laboratory Medicine 137, no. 12 (2013): 1770–73. http://dx.doi.org/10.5858/arpa.2013-0012-oa.

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Context.—Previous studies have shown that there are disagreements in interlaboratory consultation, including false-negative and false-positive diagnoses. To date, methods to reduce false-negative and false-positive diagnoses have been poorly documented. Objective.—To identify features associated with false-negative and false-positive diagnoses in anatomic pathology. Design.—We reviewed the results of interlaboratory consultation in our institution during a 9-year period. For false-negative and false-positive diagnoses, methods that might have prevented the error were identified. Results.—Disag
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Trent, Vincent, Kamal K. Khurana, and Latha R. Pisharodi. "Diagnostic Accuracy and Clinical Utility of Endoscopic Bile Duct Brushing in the Evaluation of Biliary Strictures." Archives of Pathology & Laboratory Medicine 123, no. 8 (1999): 712–15. http://dx.doi.org/10.5858/1999-123-0712-daacuo.

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Abstract Pathologic evidence of malignancy in biliary strictures is useful in the preoperative setting because it helps define therapeutic planning and prognosis. The purpose of this study was to assess the diagnostic accuracy and clinical utility of endoscopic bile duct brushings in the evaluation of bile duct strictures. We retrospectively evaluated 34 endoscopic biliary brushings derived from 31 patients with bile duct strictures. Relevant clinical and follow-up data were collected. Histologic specimens were reviewed in patients undergoing subsequent biopsies. Patients included 18 men and 1
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9

Hamburger, Joel I., and Mujtaba Husain. "Semiquantitative criteria for fine-needle biopsy diagnosis: Reduced false-negative diagnoses." Diagnostic Cytopathology 4, no. 1 (1988): 14–17. http://dx.doi.org/10.1002/dc.2840040105.

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10

Osborne, J. E., J. F. Bourke, R. A. C. Graham-Brown, and P. E. Hutchinson. "False negative clinical diagnoses of malignant melanoma." British Journal of Dermatology 140, no. 5 (1999): 902–8. http://dx.doi.org/10.1046/j.1365-2133.1999.02823.x.

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11

Moser, Patrizia L., Ingo H. Lorenz, Peter Sögner, Sylvia Stadlmann, Gregor Mikuz, and Christian Kolbitsch. "The accuracy of telediagnosis of frozen sections is inferior to that of conventional diagnosis of frozen sections and paraffin-embedded sections." Journal of Telemedicine and Telecare 9, no. 3 (2003): 130–34. http://dx.doi.org/10.1258/135763303767149915.

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The accuracy of telepathology diagnosis and conventional diagnosis of frozen sections was compared, using the diagnosis established on paraffin-embedded tissue as a reference. Out of a total of 270 cases, remote frozen-section diagnosis was correct in 227 cases (84.1%) and incorrect in 23 cases (8.5%). The latter comprised 12 false positive diagnoses of malignancy (4.4%) and 11 false negative diagnoses (4.1%). A diagnosis was not possible in 20 cases (7.4%). In contrast, the conventional frozen-section diagnosis was correct in 269 cases (99.6%) and incorrect in 1 case (0.4%), the latter being
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12

Auger, Manon, Ann T. Moriarty, Rodolfo Laucirica, et al. "Granulomatous Inflammation—An Underestimated Cause of False-Positive Diagnoses in Lung Fine-Needle Aspirates: Observations From the College of American Pathologists Nongynecologic Cytopathology Interlaboratory Comparison Program." Archives of Pathology & Laboratory Medicine 134, no. 12 (2010): 1793–96. http://dx.doi.org/10.5858/2009-0491-cpr2.1.

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Abstract Context—The false-positive rate for fine-needle aspirates of the lung has been cited as less than 1% for granulomatous inflammation, comprising one of the known causes of false-positive diagnoses. Objective—To determine the rate of false-positive diagnoses of granulomatous inflammation for lung fine-needle aspirates by assessing the false-positive response rate in the context of the College of American Pathologists Nongynecologic Cytopathology Interlaboratory Comparison Program. Design—We performed a retrospective review of 1092 participant responses for lung fine-needle aspirate chal
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López-Gatius, Fernando, Sergi Ganau, and Irina Garcia-Ispierto. "Evaluation of a Commercial Pregnancy Test Using Blood or Plasma Samples in High-Producing Dairy Cows." Animals 14, no. 11 (2024): 1656. http://dx.doi.org/10.3390/ani14111656.

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This study evaluated a commercial pregnancy-associated glycoproteins (PAGs)-based pregnancy test using whole blood or plasma samples during early pregnancy (28–55 days of gestation) in high-producing dairy cows. Transrectal ultrasonography was used as the gold standard method. The study population constituted of 284 cows. False positive diagnoses were recorded from Day 60 to 89 and from Day 60 to 99 postpartum in blood and plasma samples, respectively. In early pregnancy screening, correct positive diagnoses were recorded in 75% and 100% of blood and plasma samples, respectively. High milk pro
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Ndlovu, Ntombizodwa, David Rees, Jill Murray, Naseema Vorajee, Guy Richards, and Jim teWaterNaude. "Asbestos-related diseases in mineworkers: a clinicopathological study." ERJ Open Research 3, no. 3 (2017): 00022–2017. http://dx.doi.org/10.1183/23120541.00022-2017.

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The accurate diagnosis of asbestos-related diseases is important because of past and current asbestos exposures. This study evaluated the reliability of clinical diagnoses of asbestos-related diseases in former mineworkers using autopsies as the reference standard.Sensitivity, specificity, positive predictive value and negative predictive value were calculated.The 149 cases identified had clinical examinations 0.3–7.4 years before death. More asbestos-related diseases were diagnosed at autopsy rather than clinically: 77 versus 52 for asbestosis, 27 versus 14 for mesothelioma and 22 versus 3 fo
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Van Dyck, Pieter, Jasper Vandenrijt, Thijs Vande Vyvere, Annemiek Snoeckx, and Christiaan H. W. Heusdens. "Analysis of Discordant Findings between 3T Magnetic Resonance Imaging and Arthroscopic Evaluation of the Knee Meniscus." Journal of Clinical Medicine 12, no. 17 (2023): 5667. http://dx.doi.org/10.3390/jcm12175667.

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Numerous studies have assessed the performance of magnetic resonance imaging (MRI) in detecting tears of the knee menisci using arthroscopy results as the gold standard, but few have concentrated on the nature of discordant findings. The purpose of this study was to analyze the discordances between 3T MRI and arthroscopic evaluation of the knee meniscus. Medical records of 112 patients who underwent 3T MRI and subsequent arthroscopy of the knee were retrospectively analyzed to determine the accuracy of diagnoses of meniscal tear. Compared with arthroscopy, there were 22 false-negative and 14 f
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16

Mihok, Steve. "Pregnancy test for meadow voles (Microtus pennsylvanicus) based on blood azurocyte counts." Canadian Journal of Zoology 65, no. 11 (1987): 2830–32. http://dx.doi.org/10.1139/z87-430.

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Voles of the genus Microtus possess a unique leukocyte that contains large purple inclusions visible with light microscopy. Counts of "azurocytes" from females in different reproductive states indicate that pregnancy can be diagnosed absolutely by the presence of at least 400 azurocytes/μL in the peripheral blood. Other criteria may be used for specific groups of animals to diagnose both sexual maturity and pregnancy with few false-positive diagnoses.
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17

Colgan, Terence J., Sherry L. Woodhouse, Patricia E. Styer, Mary Kennedy, and Diane D. Davey. "Reparative Changes and the False-Positive/False-Negative Papanicolaou Test." Archives of Pathology & Laboratory Medicine 125, no. 1 (2001): 134–40. http://dx.doi.org/10.5858/2001-125-0134-rcatfp.

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Abstract Context.—Reparative changes can be a diagnostic challenge on Papanicolaou tests and must be distinguished from epithelial cell abnormalities. Both squamous intraepithelial lesions (SIL) and carcinoma may be underdiagnosed as repair. This study examines laboratory and cytologist performance in the diagnosis of repair. Objectives.—To determine if laboratories and cytologists can consistently distinguish reparative changes from SIL and carcinoma and to document how often SIL and carcinoma are mistaken for repair in a standardized educational slide program. Design.—Results for reparative
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18

OʼConnor, D. M., C. Mosbrucker, E. Kane, and M. Henry. "An Analysis of False-Positive Cervical Cytology Diagnoses." Journal of Lower Genital Tract Disease 1, no. 1 (1997): 21. http://dx.doi.org/10.1097/00128360-199701000-00011.

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19

Yamatsuji, Tomoki, Naomasa Ishida, Munenori Takaoka, et al. "False-Positive Cases of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomographic Scans in Metastasis of Esophageal Cancer." Clinical Medicine Insights: Case Reports 10 (January 1, 2017): 117954761770340. http://dx.doi.org/10.1177/1179547617703402.

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Of 129 esophagectomies at our institute from June 2010 to March 2015, we experienced three preoperative positron emission tomography-computed tomographic (PET/CT) false positives. Bone metastasis was originally suspected in 2 cases, but they were later found to be bone metastasis negative after a preoperative bone biopsy and clinical course observation. The other cases suspected of mediastinal lymph node metastasis were diagnosed as inflammatory lymphadenopathy by a pathological examination of the removed lymph nodes. Conducting a PET/CT is useful when diagnosing esophageal cancer metastasis,
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20

Morant, Steven V., Frank H. Dodd, and Roger P. Natzke. "Consequences of diagnostic errors in mastitis therapy trials." Journal of Dairy Research 55, no. 3 (1988): 315–29. http://dx.doi.org/10.1017/s0022029900028570.

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SummaryThe effect of errors that occur in the diagnosis of intramammary infectious mastitis on the precision of experiments measuring the efficacy of mastitis therapy has been investigated. Diagnostic errors within the range found by experienced workers can create large biases in the apparent cure rate of therapy particularly at cure rates of less than 0·5. Using confirmed methods of diagnosis rather than single samples and reducing the probabilities of false positive and false negative diagnoses to 0·01 and 0·05 respectively, the biases in the apparent cure rates are reduced to acceptable lev
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21

Sidiropoulos, Konstantinos G., M. Estela Martinez-Escala, Oriol Yelamos, Joan Guitart, and Michael Sidiropoulos. "Primary cutaneous T-cell lymphomas: a review." Journal of Clinical Pathology 68, no. 12 (2015): 1003–10. http://dx.doi.org/10.1136/jclinpath-2015-203133.

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Primary cutaneous T-cell lymphomas (CTCLs) represent a number of extranodal lymphomas arising from a malignant population of lymphocytes in the skin, with the most common type being mycosis fungoides (MF) representing half of all primary CTCLs. Despite advances in immunohistochemistry and molecular methodology, significant diagnostic challenges remain due to phenotypic overlap of primary CTCLs with several inflammatory dermatoses, secondary lymphomas, among other conditions. Clinical features such as presentation and morphology, staging, histology, immunophenotype and molecular features must b
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22

Koger, K., J. E. Andruchow, A. D. McRae, D. Wang, G. Innes, and E. S. Lang. "P081: ICD-10 coding of free text diagnoses is not reliable for the diagnosis of PE in Calgary zone emergency department patients." CJEM 20, S1 (2018): S85. http://dx.doi.org/10.1017/cem.2018.279.

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Introduction: Administrative data are attractive for research, policy and quality improvement initiatives as large amounts of data can often be obtained quickly and at low cost. Unfortunately, administrative data often have significant limitations owing to how they were collected and coded. In many cases, free text, often hand written, diagnoses provided by physicians are converted into ICD-10 (International Statistical Classification of Diseases and Related Health Problems, 10th Revision) codes by trained nosologists for administrative purposes. However, because of the large data sets often o
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van der Kwast, T. H., C. Lopes, P. M. Martikainen, et al. "Report of the Pathology Committee: false-positive and false-negative diagnoses of prostate cancer." BJU International 92, s2 (2003): 62–65. http://dx.doi.org/10.1111/j.1465-5101.2003.04400.x.

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24

Bell, Lauren, Ann Louise Hunter, Angelos Kyriacou, Annice Mukherjee, and Akheel A. Syed. "Clinical diagnosis of Graves’ or non-Graves’ hyperthyroidism compared to TSH receptor antibody test." Endocrine Connections 7, no. 4 (2018): 504–10. http://dx.doi.org/10.1530/ec-18-0082.

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Background TSH receptor antibody (TRAb) is considered the gold standard diagnostic test for the autoimmunity of Graves’ disease (GD), which is commonly diagnosed clinically. Aim To evaluate the true positive (sensitivity) and true negative (specificity) rates of clinical diagnosis of GD or non-GD hyperthyroidism compared to the TRAb test. Setting University teaching hospital in North West England. Participants Patients in the Endocrinology service who had a TRAb measurement between December 2009 and October 2015. Methods Electronic patient records were studied retrospectively for a pre-TRAb cl
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Haver, Brit. "When a Doctor Becomes a Patient with a Mystery Illness: A Case Report." Case Reports in Medicine 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/565980.

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Symptoms presenting as mental disorders may represent epileptic discharges, especially from the temporal lobe. Both mental and somatic symptoms are common in temporal lobe epilepsy, which may confuse doctors, leading to extensive medical examinations and tests, false diagnoses, and ineffective treatment. Also, the episodic nature and variety of symptoms between as well as in individual cases hinder correct diagnosis. Since epileptic discharges may be visible on EEG only during an epileptic fit—and may need highly specialized equipment to detect—many cases are undiagnosed or treated under false
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Gale, Kevin, Daniel Fellows Pease, Joseph Guinness, and Andres Wiernik. "Clinical implications of the 2012 US Preventive Services Task Force (USPSTF) PSA screening recommendation in prostate cancer diagnoses and 5-year survival at a Minnesota safety net health care system." Journal of Clinical Oncology 35, no. 15_suppl (2017): 5051. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.5051.

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5051 Background: Prostate specific antigen (PSA) screening for prostate cancer has declined following the USPSTF 2012 recommendation. How screening rates and prostate cancer diagnoses have subsequently changed in a racially diverse patient population is not well defined. In this study, we aim to determine the impact of the USPSTF screening recommendation in the Hennepin Healthcare System (HHS) in the state of Minnesota. Methods: A single-institution retrospective analysis of data from our electronic health record, to identify the characteristics of PSA screening and new prostate cancer diagnos
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Peipert, Jeffrey F., and David E. Soper. "Diagnostic Evaluation of Pelvic Inflammatory Disease." Infectious Diseases in Obstetrics and Gynecology 2, no. 1 (1994): 38–48. http://dx.doi.org/10.1155/s1064744994000384.

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Pelvic inflammatory disease (PID) is a serious public health and reproductive health problem in the United States. An early and accurate diagnosis of PID is extremely important for the effective management of the acute illness and for the prevention of long-term sequelae. The diagnosis of PID is difficult, with considerable numbers of false-positive and false-negative diagnoses. An abnormal vaginal discharge or evidence of lower genital tract infection is an important and predictive finding that is often underemphasized and overlooked. This paper reviews the clinical diagnosis and supportive l
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Sharma, H., S. Bhagat, and WJ Gaine. "Reducing Diagnostic Errors in Musculoskeletal Trauma by Reviewing Non-Admission Orthopaedic Referrals in the Next-Day Trauma Meeting." Annals of The Royal College of Surgeons of England 89, no. 7 (2007): 692–95. http://dx.doi.org/10.1308/003588407x205305.

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INTRODUCTION Diagnostic errors in orthopaedics are usually caused by missing a fracture or misreading radiographs. The aim of this study was to document the pick-up rate of the wrong diagnoses by reviewing X-rays and casualty notes in the next-day trauma meeting. PATIENTS AND METHODS The casualty notes and radiographs of 503 patients were prospectively reviewed in the daily trauma meeting between August 2002 and December 2002 in a district general hospital. The relevant data were collected and analysed by a single assessor. RESULTS The false positive rate for making an orthopaedic diagnosis wa
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Anbari, Martin M., and O. Clark West. "Cervical spine trauma radiography: Sources of false-negative diagnoses." Emergency Radiology 4, no. 4 (1997): 218–24. http://dx.doi.org/10.1007/bf01508174.

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SPLETE, HEIDI. "False-Positive Parkinson's Disease Diagnoses Common; Avoid the Pitfalls." Family Practice News 36, no. 8 (2006): 66. http://dx.doi.org/10.1016/s0300-7073(06)73056-0.

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31

Frazier, Dianne M., Evelyn H. Clemons, and Henry N. Kirkman. "Minimizing false positive diagnoses in newborn screening for galactosemia." Biochemical Medicine and Metabolic Biology 48, no. 3 (1992): 199–211. http://dx.doi.org/10.1016/0885-4505(92)90066-8.

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32

Guggisberg, Kelly, Chukwudi Okorie, and Moosa Khalil. "Cytopathology Including Fine-Needle Aspiration in Sub-Saharan Africa: A Cameroon Experience." Archives of Pathology & Laboratory Medicine 135, no. 2 (2011): 200–206. http://dx.doi.org/10.5858/135.2.200.

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Abstract Context.—Surgical pathology is unavailable in most of sub-Saharan Africa because of equipment costs and lack of expertise. Cytopathology is an inexpensive and reliable alternative. Objective.—To explore the utility of cytopathology in a rural hospital setting in Africa. Design.—A cytopathologist and a pathology resident from Calgary, Alberta, Canada, went to Cameroon to provide a cytopathology service at the Banso Baptist Hospital. Both performed the fine-needle aspiration procedures. Direct smears were fixed in alcohol and stained with hematoxylin-eosin. Surgical specimens subsequent
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Ashimori, Naoki, Hiroyuki Mineta, and Minako Tsurita. "S129 – Analysis of Fine Needle Biopsy for Malignant Lymphoma." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P120—P121. http://dx.doi.org/10.1016/j.otohns.2008.05.302.

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Objectives To review fine-needle aspiration biopsy-(FNAB) diagnosis of malignant lymphoma retrospectively to determine the diagnostic accuracy and pitfalls. Methods 68 cases of malignant lymphoma and 52 cases of non-malignant lymphoma were identified between 1997 and 2004. All cases were recognized as cervical lymphadenopathy and evaluated by FNAB. Open biopsies were also performed to obtain final diagnoses. Malignant lymphomas were subclassified according to World Health Organization classifications. We compared the FNAB and final diagnostic results to determine the diagnostic accuracy and ex
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Segnan, Nereo, Silvia Minozzi, Antonio Ponti, et al. "Estimate of false-positive breast cancer diagnoses from accuracy studies: a systematic review." Journal of Clinical Pathology 70, no. 4 (2017): 282–94. http://dx.doi.org/10.1136/jclinpath-2016-204184.

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BackgroundFalse-positive histological diagnoses have the same consequences of overdiagnosis in terms of unnecessary treatment. The aim of this systematic review is to assess their frequency at needle core biopsy (CB) and/or surgical excision of the breast.MethodsPubMed, Embase, Cochrane Library were systematically searched up to 30 October 2015. Eligibility criteria: cross-sectional studies assessing diagnostic accuracy of CB compared with surgical excision; studies assessing reproducibility of pathologists reading the same slides. Outcomes: false-positive rates; Misclassification of Benign as
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Rokitte, Karin, Kristina Tendl-Schulz, Ulrike Heber, et al. "Abstract P1-02-07: Accuracy and predictive value of resection margin assessment by intraoperative frozen section after neoadjuvant therapy: An analysis of the ABCSG 24 and 34 trials." Cancer Research 82, no. 4_Supplement (2022): P1–02–07—P1–02–07. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-02-07.

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Abstract Data on the accuracy of intraoperative resection margin assessment and its influence on survival after neoadjuvant therapy (NT) are scarce. In the present study, we analyzed the accuracy of resection margin assessment by intraoperative frozen section (IFS) in the prospectively randomized neoadjuvant clinical trials ABCSG 24 and ABCSG 34.164 patients with early breast cancer who received NT within the ABCSG 24 and ABCSG 34 trials between 2005 and 2015, and received IFS resection margin assessment were included in our analysis. Resection margin status by IFS was compared to subsequent F
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Wanti, Linda Perdana, Nur Wachid Adi Prasetya, Zahrun Nafisa, Rahmat Mulyadi, and Muhammad Ramadani. "Fuzzy Expert System for Decission Support to Diagnosis Leukemia." Journal of Innovation Information Technology and Application (JINITA) 7, no. 1 (2025): 26–34. https://doi.org/10.35970/jinita.v7i1.2349.

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Leukemia is a cancer of the blood and bone marrow. In leukemia, the bone marrow produces too many abnormal white blood cells. These abnormal cells cannot fight infections well and can displace healthy blood cells, which can cause anemia and bleeding. In this study, a fuzzy method will be implemented to diagnose leukemia and the results will later be compared with expert diagnoses. Fuzzy logic was chosen because it allows for degrees of truth between 0 (completely false) and 1 (completely true) and it is suitable for situations where human expertise relies on experience and judgment rather than
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Geijer, Mats, Olof Laurin, Ragnar Johnsson, and Sven Laurin. "A computer-assisted systematic quality monitoring method for cervical hip fracture radiography." Acta Radiologica Open 5, no. 12 (2016): 205846011667474. http://dx.doi.org/10.1177/2058460116674749.

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Background A thorough quality analysis of radiologic performance is cumbersome. Instead, the prevalence of missed cervical hip fractures might be used as a quality indicator. Purpose To validate a computer-based quality study of cervical hip fracture radiography. Material and Methods True and false negative and positive hip trauma radiography during 6 years was assessed manually. Patients with two or more radiologic hip examinations before surgery were selected by computer analysis of the databases. The first of two preoperative examinations might constitute a missed fracture. These cases were
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Rodriguez-Palacios, Alexander, Henry R. Stämpfli, and Yung-Fu Chang. "False-Positive Clostridium difficile in Negative-Control Reactions Peak and Then Decrease with Repetitive Refrigeration of Immunoassay." International Scholarly Research Notices 2014 (September 11, 2014): 1–3. http://dx.doi.org/10.1155/2014/128120.

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Aberrant false-positive reactions in negative-controls during ELISA testing for Clostridium difficile indicated the potential for false-diagnoses. Experiments with 96-well products showed a maximum peak of false-positive immunoassay reactions with the provided negative-control reagents after 5 refrigeration-to-room temperature cycles (P<0.001), decreasing thereafter with additional refrigeration cycles. Because repetitive refrigeration causes a peak of false-positives, the use of single negative-controls per ELISA run might be insufficient to monitor aberrant preanalytical false-positives i
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Sánchez-Pardo, Santiago, Jaime Andrés Osorio-Ramírez, Isabela Choi-Park, Daniel Felipe Rojas-Holguín, and Adrián Bolívar-Mejía. "False-positive fourth-generation HIV test associated with autoimmune hemolytic anemia. Case report." Case reports 5, no. 2 (2019): 132–38. http://dx.doi.org/10.15446/cr.v5n2.78532.

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Introduction: The fourth-generation ELISA human immunodeficiency virus (HIV) screening test has a high sensitivity and specificity >99% to detect both antigens and antibodies. Estimates are that only 0.5% yield false positive results.Case description: 61-year-old female patient with a clinical picture consisting of malaise, unquantified fever, asthenia and adynamia. Laboratory tests revealed anemia, so a Coombs test was performed, obtaining a positive result along with other findings of mixed autoimmune hemolytic anemia. Two fourth-generation ELISA HIV screening tests were performed obtaini
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Koca, Yavuz Savas, Bünyamin Aydın, Tugba Koca, Mustafa Tevfik Bülbül, and Mehmet Numan Tamer. "Insulinoma-Induced Hypoglycemia in a Patient with Insulinoma after Gastrojejunostomy for Prepyloric Ulcer." Case Reports in Surgery 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/127914.

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Hyperinsulinism due to dumping syndrome following gastric surgery is an uncommon condition. It is specified with hypoglycemic attacks. However, linking symptoms to dumping syndrome in each patient to whom gastric surgery was performed leads to inappropriate diagnosis and therapy. Insulinoma and other causes that give rise to hyperinsulinemia should not be ignored and these diagnoses should be excluded. In this paper, 71-year-old male patient who was followed up for 2 years with a false conclusion of dumping syndrome and operated on due to insulinoma diagnosed at endoscopic ultrasonography is p
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Arps, David P., Stephanie Chen, Douglas R. Fullen, and Alexandra C. Hristov. "Selected Inflammatory Imitators of Mycosis Fungoides: Histologic Features and Utility of Ancillary Studies." Archives of Pathology & Laboratory Medicine 138, no. 10 (2014): 1319–27. http://dx.doi.org/10.5858/arpa.2014-0298-cc.

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Mycosis fungoides is the most common primary cutaneous lymphoma; however, it remains a significant diagnostic challenge, in part because of the overlap with several inflammatory dermatoses. Despite advances in immunohistochemistry and molecular diagnostics, false-positive, false-negative, and indeterminate diagnoses are not uncommon. In most cases, the overall balance of morphologic, immunophenotypic, and genetic features must be considered carefully because there are few sensitive and specific clues to the diagnosis. Moreover, an appropriate clinical presentation is essential to the diagnosis
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Taylor, Brice, Michael Alexander, Colleen Karvestski, Megan Templin, and Stephanie Taylor. "1354: AN AGGRESSIVE SEPSIS IDENTIFICATION INITIATIVE INCREASES FALSE-POSITIVE DIAGNOSES." Critical Care Medicine 44, no. 12 (2016): 414. http://dx.doi.org/10.1097/01.ccm.0000510028.38103.d8.

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Dyer, O. "US oncologist faces life in prison for false cancer diagnoses." BMJ 349, sep19 4 (2014): g5738. http://dx.doi.org/10.1136/bmj.g5738.

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Peck, Martyn, David Moffat, Bruce Latham, and Tony Badrick. "Review of diagnostic error in anatomical pathology and the role and value of second opinions in error prevention." Journal of Clinical Pathology 71, no. 11 (2018): 995–1000. http://dx.doi.org/10.1136/jclinpath-2018-205226.

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AimsDiagnostic/interpretative accuracy can be challenging in anatomical pathology due to the subjective element of the diagnostic process. This can lead to false-negative or false-positive diagnoses of malignancy, variations in grading and diagnostic misclassification of a condition.It is imperative that an accurate diagnosis is achieved so that an appropriate and timely treatment is administered to the patient, for example, the success of targeted molecular therapeutic options for treatment of cancer is dependent on accurate anatomical pathology diagnoses being issued.MethodsA literature revi
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Mohammed, Hezha. "THE ACCURACY OF THE LOW DOSE NATIVE COMPUTED TOMOGRAPHY PROTOCOL IN PATIENTS WITH SUSPECTED ACUTE APPENDICITIS." Journal of Sulaimani Medical College 14, no. 4 (2024): 349–58. https://doi.org/10.17656/jsmc.10482.

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Background To determine the accuracy of native computed tomography (CT) without the oral, intravenous, or rectal administration of contrast material in confirming suspected acute appendicitis. Objectives the prospective study conducted within six months in Shar hospital in cases were admitted with the abdominal pain and suspicion of acute appendicitis, and determination of the acute appendicitis diagnosed by clinical manifestations, ultrasound to exclude other possible right iliac fossa pain and then native low dose CT scan of the pelvic was done to diagnose acute appendicitis and determine th
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White, Valerie A., and Martin J. Trotter. "Intraoperative Consultation/Final Diagnosis Correlation: Relationship to Tissue Type and Pathologic Process." Archives of Pathology & Laboratory Medicine 132, no. 1 (2008): 29–36. http://dx.doi.org/10.5858/2008-132-29-ifdcrt.

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Abstract Context.—The correlation of the diagnosis made at intraoperative consultation (IC) with the final diagnosis is one of the cornerstones of quality assurance in the anatomic pathology laboratory. Objective.—To review correlation of IC diagnoses with final diagnoses during a 1-year period in a regionalized, multisite hospital setting in a major Canadian city. Design.—One pathologist reviewed all surgical pathology cases at Calgary Laboratory Services from June 2004 through May 2005 that had an IC to extract the following data points: intraoperative diagnoses, final diagnoses, correlation
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Quon, Jeffrey S., Bardia Moosavi, Maneesh Khanna, Trevor A. Flood, Christopher S. Lim, and Nicola Schieda. "False positive and false negative diagnoses of prostate cancer at multi-parametric prostate MRI in active surveillance." Insights into Imaging 6, no. 4 (2015): 449–63. http://dx.doi.org/10.1007/s13244-015-0411-3.

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Mizushima, I., N. Morikage, E. Ito, et al. "OP0256 VALIDATION OF THE 2019 ACR/EULAR CLASSIFICATION CRITERIA FOR IGG4-RELATED DISEASE AND THE JAPANESE ORGAN-SPECIFIC DIAGNOSTIC CRITERIA IN A JAPANESE IGG4-RELATED PERIAORTITIS/RETROPERITONEAL FIBROSIS COHORT: A NATIONWIDE MULTICENTER STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 169.2–170. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4199.

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BackgroundDiagnosing IgG4-related periaortitis/retroperitoneal fibrosis (IgG4-PA/RPF) is often challenging, especially in PA/RPF-limited cases, due to the difficulty in obtaining periaortic/retroperitoneal specimens. In addition to the Japanese diagnostic criteria for IgG4-PA/RPF [1], the 2019 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for IgG4-related disease (IgG4-RD) [2] have not been validated for IgG4-PA/RPF diagnosis in daily clinical practice.ObjectivesThis study aimed to validate the ACR/EULAR classification criteria and th
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Tereshchenko, V. "Comparison of methods for the diagnosis of H.pylori in gastric biopsy specimens from patients with different gastrointestinal diseases." Immunopathology, Allergology, Infectology 2021, no. 4 (2021): 91–96. http://dx.doi.org/10.14427/jipai.2021.4.91.

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This paper presents a comparison of cultural and rapid urease tests for the detection of H.pylori presence with PCR in biopsy specimens from patients diagnosed with gastroduodenitis, chronic gastritis, duodenitis and reflux oesophagitis. In general, there was a trend towards more false positive results when using the rapid urease testing method and false negatives when using the cultural method is used, but this pattern was statistically significant only for the diagnoses of gastroduodenitis (for all methods) and chronic gastritis (there was no statistically significant difference between PCR
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Deepika, P., and P. Pabitha. "Evaluation of Convolutional Neural Network Architecture for Feasibility Analysis on Fetal Abdomen and Brain Images." Journal of Medical Imaging and Health Informatics 11, no. 10 (2021): 2573–83. http://dx.doi.org/10.1166/jmihi.2021.3844.

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This research aims to evaluate the possibilities of fetus ultrasound image classification using machine learning algorithms as normal or abnormal. Most of the earlier research works have produced a high percentage of false-negative classification results—recent research work aimed to reduce the rate of false-negative diagnoses. Also, the number of sonologists for analyzing prenatal ultrasound worldwide is very less and solved by developing an efficient algorithm, which reduces the percentage of false negatives in the diagnosis output. Several earlier research works focused on analyzing fetal a
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