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Dissertations / Theses on the topic 'Familial aggregation'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Tahir, Hassaan. "Familial Aggregation of Severe Preeclampsia." Thesis, Linköpings universitet, Statistik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73266.

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It has been proved from several studies that the genetic influence has been the most significant factor for having preeclampsia (PE). Still there are many uncertainties about origin and magnitude of the genetic effects as no specific inheritance patterns have been established. In this study, heritage risk of PE is in both the woman’s family and her partner’s family to her risk of PE is examined, along women and men own history with same and different partners. Moreover it is also examined whether timing of onset of PE is also has any impact on familial clustering of PE. Here, we used the popul

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2

Pappas, Sylvie Rachelle. "The familial aggregation of agoraphobia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0017/MQ47079.pdf.

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3

Beaujeux, Timothy Paul. "Protein aggregation in a mouse model of familial motor neurone disease." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427349.

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4

Seeley, John Robert. "Comorbidity between conduct disorder and major depression : phenomenology, correlates, course, and familial aggregation /." view abstract or download file of text, 2001. http://wwwlib.umi.com/cr/uoregon/fullcit?p3035576.

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Thesis (Ph. D.)--University of Oregon, 2001.<br>"Based on data collected from the Oregon Adolescent Depresssion Project (OADP)."--Abstract. Typescript. Includes vita and abstract. Includes bibliographical references (leaves 73-84). Also available for download via the World Wide Web; free to University of Oregon users.

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5

Brauer, Paula Mae. "Familial aggregation of diabetes, hypertension and cardiovascular conditions in a case-control study of colorectal neoplasia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0023/NQ49836.pdf.

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6

Tisler, Andras. "Analysis of the familial aggregation of hypertension among patients with different types of kidney stone disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0022/MQ40818.pdf.

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7

Räsänen, Maija. "Familial aggregation and risk factors for asthma and hay fever among Finnish adolescent twins : a twin family study." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/kansa/vk/rasanen/.

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Andersson, Karin, M. Pokrzywa, Ingrid Dacklin, and Erik Lundgren. "Inhibition of TTR aggregation-induced cell death : a new role for serum amyloid P component." Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-65622.

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BACKGROUND: Serum amyloid P component (SAP) is a glycoprotein that is universally found associated with different types of amyloid deposits. It has been suggested that it stabilizes amyloid fibrils and therefore protects them from proteolytic degradation. METHODOLOGY/PRINCIPAL FINDINGS: In this paper, we show that SAP binds not only to mature amyloid fibrils but also to early aggregates of amyloidogenic mutants of the plasma protein transthyretin (TTR). It does not inhibit fibril formation of TTR mutants, which spontaneously form amyloid in vitro at physiological pH. We found that SAP prevents

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de, Zwaan Sally Elizabeth. "The Genetics of Basal Cell Carcinoma of the Skin." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3878.

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BCC is the commonest cancer in European-derived populations and Australia has the highest recorded incidence in the world, creating enormous individual and societal cost in management of this disease. The incidence of this cancer has been increasing internationally, with evidence of a 1 to 2% rise in incidence in Australia per year over the last two decades. The main four epidemiological risk factors for the development of BCC are ultraviolet radiation (UVR) exposure, increasing age, male sex, and inability to tan. The pattern and timing of UVR exposure is important to BCC risk, with childhood

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de, Zwaan Sally Elizabeth. "The Genetics of Basal Cell Carcinoma of the Skin." University of Sydney, 2008. http://hdl.handle.net/2123/3878.

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Doctor of Philosophy(PhD)<br>BCC is the commonest cancer in European-derived populations and Australia has the highest recorded incidence in the world, creating enormous individual and societal cost in management of this disease. The incidence of this cancer has been increasing internationally, with evidence of a 1 to 2% rise in incidence in Australia per year over the last two decades. The main four epidemiological risk factors for the development of BCC are ultraviolet radiation (UVR) exposure, increasing age, male sex, and inability to tan. The pattern and timing of UVR exposure is importan

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Knight, Ann. "Clinical and Epidemiological Studies of Wegener´s Granulomatosis." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7887.

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<p>Wegener´s granulomatosis (WG) is an unusual, serious, systemic vasculitis with specific clinical findings. The studies in this thesis aim at broadening our understanding of the aetiology and outcome of WG.</p><p>Patients with WG were identified in the In-patient Register 1975-2001. During this time the incidence increased three-fold, and neither ANCA-related increased awareness, nor diagnostic drift, seem to fully explain this trend, but it is still unclear if a true rise in incidence exists. </p><p>Anti- neutrophil cytoplasmic antibodies (ANCA) have been presented as highly specific for va

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Jones, Luke D. "Early knee arthritis : symptoms and structure." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:fafe8d46-9ad5-4d1e-b8f5-b2ea3757b3fb.

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Knee osteoarthritis (OA) is the commonest form of lower limb OA with a lifetime risk of over 40%. It is a disease characterised by symptoms such as pain and loss of function. In addition there are typical structural features on both radiographs and MRI. Knee OA represents a spectrum of disease, ranging from early preclinical cartilage change to established full thickness disease. Anteromedial knee OA is a particular phenotype of knee OA where disease is confined to the medial compartment. Whilst end stage arthritis is treated reliably with joint arthroplasty, those with early stage disease are

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13

Schreier, Andrea, Michael Höfler, Hans-Ulrich Wittchen, and Roselind Lieb. "Clinical characteristics of Major Depressive Disorder run in families – A community study of 933 mothers and their children." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-110222.

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The familial aggregation of Major Depressive Disorder (MDD) has been repeatedly demonstrated. Several studies have investigated associations between various clinical characteristics of MDD in probands and overall rates of MDD in relatives. Few studies, however, have considered the familial aggregation of clinical characteristics of MDD. The aim of the present report is to examine mother–offspring associations of a variety of clinical characteristics of MDD in a general population sample. Data were derived from baseline and 4-year-follow-up data of 933 adolescents and their biological mothers o

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Bergström, Joakim. "Apolipoprotein A-IV and Transthyretin in Swedish Forms of Systemic Amyloidosis." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4535.

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<p>Over 20 different plasma proteins have been shown to have the capacity to undergo conformational changes and self-assemble into highly stable and insoluble amyloid fibrils. </p><p>One, transthyretin (TTR), consists of 127 amino acid residues arranged in eight β-strands (named A to H) and is involved in two different clinical forms of amyloidosis. In familial amyloidotic polyneuropathy (FAP), mutated TTR is found in the amyloid deposits while in senile systemic amyloidosis (SSA) only wild type TTR is present in the amyloid deposits.</p><p>In this study, we have identified a novel form of amy

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Schreier, Andrea, Michael Höfler, Hans-Ulrich Wittchen, and Roselind Lieb. "Clinical characteristics of Major Depressive Disorder run in families – A community study of 933 mothers and their children." Technische Universität Dresden, 2006. https://tud.qucosa.de/id/qucosa%3A26822.

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The familial aggregation of Major Depressive Disorder (MDD) has been repeatedly demonstrated. Several studies have investigated associations between various clinical characteristics of MDD in probands and overall rates of MDD in relatives. Few studies, however, have considered the familial aggregation of clinical characteristics of MDD. The aim of the present report is to examine mother–offspring associations of a variety of clinical characteristics of MDD in a general population sample. Data were derived from baseline and 4-year-follow-up data of 933 adolescents and their biological mothers o

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16

Militão, Elza da Silva. "Caracterização da agroindústria artesanal familiar na região de Jales-SP /." Ilha Solteira: [s.n.], 2008. http://hdl.handle.net/11449/98896.

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Orientador: Silvia Maria Almeida Lima Costa<br>Banca: Antonio Lázaro Sant'Ana<br>Banca: Rosângela Aparecida de Medeiros Hespanhol.<br>Resumo: As estratégias de agregação de valor aos produtos, incluindo a agroindustrialização da produção, têm sido buscadas e vêm ganhando importância no período recente como alternativa para aumentar o grau de inserção aos mercados dos agricultores familiares. O presente trabalho analisou algumas iniciativas de agregação de valor agropecuário como opções estratégicas de geração complementar de renda para produtores rurais organizados em grupos na região de Jales

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Militão, Elza da Silva [UNESP]. "Caracterização da agroindústria artesanal familiar na região de Jales–SP." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/98896.

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Made available in DSpace on 2014-06-11T19:29:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-09-04Bitstream added on 2014-06-13T19:59:39Z : No. of bitstreams: 1 militao_es_me_ilha.pdf: 984980 bytes, checksum: 355398d8fe6a97fb608da1d0ed631782 (MD5)<br>As estratégias de agregação de valor aos produtos, incluindo a agroindustrialização da produção, têm sido buscadas e vêm ganhando importância no período recente como alternativa para aumentar o grau de inserção aos mercados dos agricultores familiares. O presente trabalho analisou algumas iniciativas de agregação de valor agropecuário

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Bezerra, Patr?cia Costa Fonseca Meirelles. "Agrega??o familiar e resultados maternos e perinatais da pr?-ecl?mpsia severa em popula??o do Rio Grande do Norte." Universidade Federal do Rio Grande do Norte, 2007. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13114.

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Made available in DSpace on 2014-12-17T14:13:21Z (GMT). No. of bitstreams: 1 PatriciaCFMB.pdf: 373126 bytes, checksum: 359c5249b6f868d7e2bf1418acaf9bec (MD5) Previous issue date: 2007-11-28<br>To determine whether there is familiar aggregation of severe preeclampsia in a Brazilian population from Rio Grande do Norte and to characterize the maternal and perinatal outcomes in the studied population. Methods: A case control study was performed with 412 participants who were admitted at Maternidade Escola Janu?rio Cicco (MEJC) for medical care. Of these, 264 subjects presented normal blood press

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Raupp, Ivan Decker. "Redes de cooperação: um estudo sobre a criação e captura de valor por produtores de hortaliças no Oeste do Paraná." Universidade Estadual do Oeste do Parana, 2012. http://tede.unioeste.br:8080/tede/handle/tede/2294.

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Made available in DSpace on 2017-07-10T18:33:55Z (GMT). No. of bitstreams: 1 Ivan Decker Raupp.pdf: 2198527 bytes, checksum: e59bf59bb1a7bf236791775e606d2cfb (MD5) Previous issue date: 2012-03-30<br>Fundação Araucária<br>The participation in horizontal cooperation networks is suggested by several authors as an important strategy so that low economic status farmers under family management can keep or improve the profitability of their entrepreneurships. In this context, the issue that guides this study is to answer whether the horizontal cooperation networks which are set up among the family

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20

Chang, Huan-Jan, and 張晃禎. "Bayesian Analysis of Familial Aggregation." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/13058779530639644046.

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碩士<br>國立臺灣大學<br>流行病學研究所<br>88<br>Familial aggregation can be expressed by correlation coefficient. There are several methods to estimate the correlation, including one-way random effects model, method of maximum likelihood and Pearson’s product-moment correlation. These methods estimate a fixed value of correlation, and does not contain any prior information. My research is using Bayesian analysis to make statistical inference about the correlation based on observations and prior information. A real application, the data of continuous performance test score of schizophrenic and their famil

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Wang, Mei-Jan, and 王美珍. "Familial aggregation of nonsmoking female lung cancer patients." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/86065729983266507768.

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碩士<br>高雄醫學院<br>公共衛生學研究所<br>84<br>ABSTRACT A case control study matched on sex and age (1:1 ratio)was performed to explore the pedigree aggregation of femalelung cancer. A total of 120 female subjects with lung cancerwere collected from The Hospital attached to KaohsiungMedical College during the hospitalized period from Jan 1992to Mar 1996, all these subjects (probands) were cigarrettenosmoking and well diagnosed as primary lung cancer. Wecollected the first-degree relatives'' data by te

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22

Tsai, Ping-Yun, and 蔡秉芸. "A Multi-level Model for Familial Aggregation of Obesity." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/94933372592890664352.

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碩士<br>國立臺灣大學<br>預防醫學研究所<br>96<br>Background and Study Purpose Obesity is increasing in prevalence worldwide and is known to be associated with morbidity and mortality in relation to cardiovascular disease. The etiology of obesity is complex and is not completely understood. A large portion of epidemiologic research put emphasis on individual-level risk factors. However, group-level or macro-level variables, so-called contextual factors, also play an important role through interaction with individual factors. There are also limited studies taking both familial aggregation and contextual factor

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Lin, Hui-Min, and 林蕙敏. "Familial aggregation studies with matched case-control proband sampling." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/95886326164728245036.

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碩士<br>淡江大學<br>統計學系碩士班<br>95<br>In this paper, some methods are proposed for the analysis of matched case-control proband data arising from familial aggregation studies. When there is no covariate information, we generalized the rank-sum test for clustered data (Datta & Satten, 2005) to detect familial aggregation. If there are some cavariate informations, we apply the generalized method of Liang & Pulver (1996) to analyze the cause of familial aggregation : genetic or environmental factors. We apply the proposed methods to obstructive sleep apnea pseudodata. Some simulation studies with finite

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XU, FANG-YUAN, and 許芳源. "Familial aggregation and multifactorial inheritance analysis of nasopharyngeal carcinoma." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/05894432206923767243.

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Xu, Fang-Yuan, and 許芳源. "Familial aggregation and multifactorial inheritance analysis of nasopharyngeal carcinoma." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/55680474345169331300.

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Huang, Kai Lin, and 黃凱琳. "Familial aggregation study of liver cancer in the penghu islets." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/20921755746805883194.

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Tibazarwa, Kemilembe B. "Peripartum cardiomyopathy: risk factor profile, familial aggregation, prognostic indicators and treatment." Thesis, 2014. http://hdl.handle.net/10539/15429.

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Introduction: Peripartum cardiomyopathy (PPCM) is a form of unexplained heart failure associated with pregnancy that leads to considerable morbidity and mortality. Most patients present with acute postpartum heart failure that otherwise resembles dilated cardiomyopathy (DCM). Little is understood about the aetiopathogenesis of PPCM, including the genetic contribution; or its treatment. I hereby report on a comprehensive collection of studies that begins with a study of familial DCM in PPCM, which incorporated genetic screening for mutations in the Lamin-A gene (LMNA), known for their virulence

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Hsun, Ya-Ching, and 許雅卿. "Detecting familial aggregation of a quantitative trait with matched proband sampling." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/56164208907824045719.

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碩士<br>淡江大學<br>統計學系碩士班<br>99<br>The preliminary work in genetic epidemiology is to determine whether a given disease shows familial aggregation. A typical design used for determination of familial aggregation should be the case-control family design which a case or a control proband is ascertained first, with subsequent recruitment of other members in the family. When some major confounders are difficult to measure, the matched case-control family is adopted. Although methods for analyzing familial data with a binary trait or unmatched design are well discussed, methods proposed for analysis of

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Ding, Yu Hao, and 丁宇壕. "Familial aggregation of type 2 diabetes and relative genetic and environmental contributions." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/57d63j.

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Lin, Wen-Yuan, and 林文元. "A Population-based Case-control Proband Study on Familial Aggregation of Metabolic Syndrome." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/03661707214270182055.

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碩士<br>國立臺灣大學<br>預防醫學研究所<br>91<br>Background Since components of metabolic syndrome (MS) like diabetes, hypertension, and hyperlipidemia usually involve the complexity of genetic and environmental factors, the separation of genetic factors from environmental factors is important for prevention of MS. Objectives The aims of this study are to use a community-based screening project (1) To estimate prevalence of MS; (2) To conduct a case-control proband study to elucidate familial aggregation of MS; (3) To assess the interacti

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Abdullahi, Hassan. "Studies of an unusual transthyretin protein (TTR GLU51_SER52DUP) associated with familial amyloidosis." Thesis, 2017. https://hdl.handle.net/2144/23758.

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Transthyretin-related amyloidosis (ATTR) is a disease involving the formation of a misfolded transthyretin (TTR) protein and resulting insoluble aggregates that deposit in extracellular regions of various tissues and organs. There are hereditary forms of the disease, referred to as ATTRm, and more than 100 TTR amyloid-forming mutants have been reported. The major goal of this work was to analyze the biochemical and biophysical properties of a unique and recently identified TTR mutant protein, TTR Glu51_Ser52dup, found in a patient with ATTRm. Unlike other single nucleotide replacements that h

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"Familial Aggregation and Biomarkers in REM Sleep Behavior Disorder: A Case-Control Family Study." 2016. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292491.

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Hiebert, Brett. "Familial aggregation of childhood health and the socioeconomic gradient of disease: a longitudinal population-based sibling analysis." 2011. http://hdl.handle.net/1993/4884.

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This study explores the relationships that emerge between socioeconomic status (SES) and the prevalence of several health outcomes in children of different ages utilizing administrative data housed at The Manitoba Centre for Health Policy (MCHP). This research also determines the effect that family has on a child developing (or not developing) a specific health outcome. Finally, the relationship between prevalence and familial aggregation are examined. The Johns Hopkins ACG(r) Case-Mix System grouped various physician and hospital diagnosis codes into 32 Aggregated Diagnostic Groups (ADGs).

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Sun, Fang-Ju, and 孫芳如. "Efficacy of atropine treatment on progression of myopia and familial aggregation of NPC by GEE." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/07113564703741162040.

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碩士<br>國立台北護理學院<br>醫護管理研究所<br>93<br>Graduate School: Department of Health Care Management, National Taipei College of Nursing Advisor: Chien-Jen Chen, Kung-Yee Liang, and Su-Chiu Chen Author: Fang-Ju Sun Title (Part 1): Efficacy of atropine treatment on progression of myopia by GEE Topics of myopia are important public health issues. For pupils who under -3.0 diopter, atropine (cycloplegics) is usually used to treat or prevent progression of myopia. This thesis is to study efficacy of atropine treatment on progression of myopia. This research follows the

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"Familial aggregation of insomnia in Hong Kong Chinese: case-control study in a prospective cohort." Thesis, 2010. http://library.cuhk.edu.hk/record=b6075048.

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Backgrounds and aims. Insomnia is a common sleep problem with significant health burden to individuals, families and society. Several risk factors contributed to the development of insomnia with significant familial aggregation phenomenon. According to this prospective study, we aimed to (1) explore the longitudinal course and outcomes of insomnia in both children and their parents; (2) confirm the familial aggregation and heritability of insomnia by detailed clinical interviews; (3) explore the potential biological markers of insomnia in terms of heart rate variability, 24-hour urinary cortis

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Lai, Yin-chieh, and 賴穎婕. "The Clinical Features, Symptom Presentation and Familial Aggregation in the Major Depressive and Bipolar Disorders in the Southern Taiwan." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/80937704066216680673.

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碩士<br>國立成功大學<br>公共衛生研究所<br>97<br>Background: Affective disorders, mainly depressive (MDD) and bipolar disorders (BPD, including BP I and BP II) are common in the general population. However, little is known about their clinical characteristics, symptoms presentation, and familial aggregation. Objects: To investigate the demographic features and the distribution of symptoms for MDD, BP I, and BP II families in the Southern Taiwan using a family study design, and to evaluate the familial aggregation on social relation in the three diagnoses. Materials and method: There were 689 participants, inc

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I-NingTsai and 蔡依凝. "Familial aggregation and prediction models of patients with early-onset and adult-onset schizophrenia and their nonpsychotic relatives using neurodevelopmental markers." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/ams36x.

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碩士<br>國立成功大學<br>臨床醫學研究所<br>103<br>Background The neurodevelopmental hypothesis proposes that schizophrenia is originated from abnormal brain development. Minor physical anomalies (MPAs) and neurological soft signs (NSSs) are suggested as biomarkers associated with disruptions of fetal development. Schizophrenia patients have been reported to have more deficits in neurodevelopmental markers than healthy controls, but family studies have produced different results. Moreover, the onset age of schizophrenia is related to the severity of the subsequent symptoms, and thus it may be possible to estim

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Mente, Andrew. "High urinary calcium excretion and familial aggregation of hypertension, kidney stone disease, obesity, excessive weight gain and type 2 diabetes in patients with calcareous stones." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=478967&T=F.

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Mulligan, Vikram. "Probing the Molecular Mechanisms Underlying Familial Amyotrophic Lateral Sclerosis: New Insight into Unfolding and Misfolding Mechanisms of the Cu, Zn Superoxide Dismutase." Thesis, 2012. http://hdl.handle.net/1807/34815.

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While great strides have been made in treating many classes of human disease, the late-onset neurodegenerative diseases continue to elude modern medicine. These diseases, which include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), the transmissible spongiform encephalopathies (TSEs), and amyotrophic lateral sclerosis (ALS), involve accumulation of insoluble aggregates of one or more causative proteins, leading to progressive loss of central nervous system neurons, progressively worsening neurological symptoms, and eventual patient death. All of these diseases

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He, Qin. "Genetic contribution to the aggregation of schizophrenia and bipolar disorder in multiplex consanguineous Pakistani pedigrees." Thèse, 2019. http://hdl.handle.net/1866/21840.

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Thyssen, Stella. "Einfluss des Proteinaggregationshemmstoffs anle138b auf Beginn und Verlauf der Amyotrophen Lateralsklerose im transgenen hSOD1-Mausmodell." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5EA3-0.

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