Academic literature on the topic 'Family cancer patient'

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Journal articles on the topic "Family cancer patient"

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Wong, Kwok F., Jackie Charman, Thomas Round, and Katherine E. Henson. "Cancer patients and primary care prescribed medications: offering insights into symptoms, polypharmacy and multimorbidity." British Journal of General Practice 68, suppl 1 (2018): bjgp18X697001. http://dx.doi.org/10.3399/bjgp18x697001.

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BackgroundNational Cancer Registration and Analysis Service (NCRAS) are responsible for registering data on all cases of cancer. For the first time individual patient level prescribing data is available, offering potential unique insights into treatment and co-morbidity.AimTo investigate the patterns of polypharmacy in cancer patients compared to non-cancer patients.MethodPrimary care prescriptions data (electronic and FP10) is currently available from April to July 2015 inclusive. Unique prescription items were summarised for each registered cancer patient; with an initial focus on opioids. These summaries were broken down by age of the patient at prescription for the most common cancers (invasive breast, colorectal, lung and prostate). Non-cancer patients were used as a comparisonResultsOverall 1,680,764 cancer patients were dispensed prescriptions during the period. On average, patients diagnosed with breast, colorectal, prostate and lung cancers received 7, 8, 8 and 10 unique drugs, respectively, throughout the 4 months. In all cases 2 of these unique drugs were opioids. In comparison, patients not diagnosed with cancer received 4 unique drugs on average: of which 2 were unique opioid drugs. Cancer patients aged 0–39, 40–69 and 70+, at prescription date, received 4, 6 and 8 unique prescriptions respectively compared to 3, 5 and 7, for non-cancer patients.ConclusionThis provides insight into primary care polypharmacy for all cancer patients in England. Analysis is underway to assess the cumulative dosage of unique drugs that patients receive, and the potential use of the data as a marker of polypharmacy/co-morbidity with larger patient level datasets.
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Waheed, Amina. "Pathways to cancer diagnosis: current state and recommendations." British Journal of General Practice 73, suppl 1 (2023): bjgp23X734313. http://dx.doi.org/10.3399/bjgp23x734313.

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BackgroundDiagnosing cancer early is crucial in improving patient outcomes. Primary care networks are encouraged to audit routes to cancer diagnosis, as suggested by the Network Contract Directed Enhanced Service Early Cancer Diagnosis Guidance.AimWe aim to measure how many patients were diagnosed with cancer in the period of April 2021 to March 2022 at an Essex GP practice, and for each of those patients, to ascertain the route of their diagnosis. We also conducted learning event analyses for patients whose diagnoses were not detected through 2-week wait (2WW) or screening.MethodSystmOne Read codes were utilised to identify all patients coded with ‘cancer’, and ‘fast-track cancer referral’. We measured the conversion rate of 2WW referrals to cancer diagnoses. For diagnoses not detected via 2WW or screening, we analysed patient notes for previous consultations and eventual route to diagnosis.ResultsIn total, 160 2WW referrals were made with a 6.25% conversion rate to cancer diagnoses. In total, 26 patients were diagnosed with cancer. Seventeen patients were diagnosed through 2WW, three through national screening programmes, three through accident and emergency, two through routine referral, and one through incidental finding. For the six patients not diagnosed through 2WW or screening, reasons why included poor patient engagement with healthcare services, referrals requiring chasing, patients passed between specialties, and failure to detect pertinent clinical signs.ConclusionIt is promising that the majority of cancers are diagnosed through 2WW and screening; however, improving patient engagement, streamlining referrals, and thorough clinical examination and documentation will reduce delayed or missed diagnoses.
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Clift, Kristin, Sarah Macklin-Mantia, Margaret Barnhorst, et al. "Comparison of a Focused Family Cancer History Questionnaire to Family History Documentation in the Electronic Medical Record." Journal of Primary Care & Community Health 13 (January 2022): 215013192110697. http://dx.doi.org/10.1177/21501319211069756.

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Introduction: Family health history can be a valuable indicator of risk to develop certain cancers. Unfortunately, patient self-reported family history often contains inaccuracies, which might change recommendations for cancer screening. We endeavored to understand the difference between a patient’s self-reported family history and their electronic medical record (EMR) family history. One aim of this study was to determine if family history information contained in the EMR differs from patient-reported family history collected using a focused questionnaire. Methods: We created the Hereditary Cancer Questionnaire (HCQ) based on current guidelines and distributed to 314 patients in the Department of Family Medicine waiting room June 20 to August 1, 2018. The survey queried patients about specific cancers within their biological family to assess their risk of an inherited cancer syndrome. We used the questionnaire responses as a baseline when comparing family histories in the medical record. Results: Agreement between the EMR and the questionnaire data decreased as the patients’ risk for familial cancer increased. Meaning that the more significant a patient’s family cancer history, the less likely it was to be recorded accurately and consistently in the EMR. Patients with low-risk levels, or fewer instances of cancer in the family, had more consistencies between the EMR and the questionnaire. Conclusions: Given that physicians often make recommendations on incomplete information that is in the EMR, patients might not receive individualized preventive care based on a more complete family cancer history. This is especially true for individuals with more complicated and significant family history of cancer. An improved method of collecting family history, including increasing patient engagement, may help to decrease this disparity.
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Palos, Guadalupe R., and Martha Hare. "Patients, family caregivers, and patient navigators." Cancer 117, S15 (2011): 3590–600. http://dx.doi.org/10.1002/cncr.26263.

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CARLOS, Celina Angélica Lisboa Valente, and Karla Maria Damiano TEIXEIRA. "ONCOLOGICAL DIAGNOSIS AND TREATMENT: REFLECTION ON THE CHANGES IN THE LIFE OF THE PATIENT AND HIS FAMILY." Boletim de Conjuntura (BOCA) 13, no. 39 (2023): 473–90. https://doi.org/10.5281/zenodo.7786596.

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The diagnosis of cancer is usually received with fear and anguish and its consequences may establish a series of changes and disruptions for the patient and his family. Thus, with the aim of reflecting on the main changes experienced by cancer patients and their families as a result of the diagnosis and treatment of the disease, a systematic literature review was carried out. For the survey of scientific production, SciELO was defined as the database and the words “cancer, changes in the family and treatment” as descriptors. For the analysis of the data found, the IRAMUTEQ software was used, prioritizing the descending hierarchical classification and the similarity classification. From the analyses, it is concluded that cancer patients undergo a series of changes both at a personal and professional level, which have an impact on family routine, family finances, spirituality, family relationships and coexistence.
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Swann, Ruth, Sean McPhail, Jana Witt, et al. "Diagnosing cancer in primary care: results from the National Cancer Diagnosis Audit." British Journal of General Practice 68, no. 666 (2017): e63-e72. http://dx.doi.org/10.3399/bjgp17x694169.

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BackgroundContinual improvements in diagnostic processes are needed to minimise the proportion of patients with cancer who experience diagnostic delays. Clinical audit is a means of achieving this.AimTo characterise key aspects of the diagnostic process for cancer and to generate baseline measures for future re-audit.Design and settingClinical audit of cancer diagnosis in general practices in England.MethodInformation on patient and tumour characteristics held in the English National Cancer Registry was supplemented by information from GPs in participating practices. Data items included diagnostic timepoints, patient characteristics, and clinical management.ResultsData were collected on 17 042 patients with a new diagnosis of cancer during 2014 from 439 practices. Participating practices were similar to non-participating ones, particularly regarding population age, urban/rural location, and practice-based patient experience measures. The median diagnostic interval for all patients was 40 days (interquartile range [IQR] 15–86 days). Most patients were referred promptly (median primary care interval 5 days [IQR 0–27 days]). Where GPs deemed diagnostic delays to have occurred (22% of cases), patient, clinician, or system factors were responsible in 26%, 28%, and 34% of instances, respectively. Safety netting was recorded for 44% of patients. At least one primary care-led investigation was carried out for 45% of patients. Most patients (76%) had at least one existing comorbid condition; 21% had three or more.ConclusionThe findings identify avenues for quality improvement activity and provide a baseline for future audit of the impact of 2015 National Institute for Health and Care Excellence guidance on management and referral of suspected cancer.
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Jefferson, Laura, Karl Atkin, Rebecca Sheridan, et al. "Non-attendance at urgent referral appointments for suspected cancer: a qualitative study to gain understanding from patients and GPs." British Journal of General Practice 69, no. 689 (2019): e850-e859. http://dx.doi.org/10.3399/bjgp19x706625.

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BackgroundThe 2-week-wait urgent referral policy in the UK has sought to improve cancer outcomes by accelerating diagnosis and treatment. However, around 5–7% of symptomatic referred patients cancel or do not attend their hospital appointment. While subsequent cancer diagnosis was less likely in non-attenders, those with a diagnosis had worse early mortality outcomes.AimTo examine how interpersonal, communication, social, and organisational factors influence a patient’s non-attendance.Design and settingQualitative study in GP practices in one Northern English city.MethodIn-depth, individual interviews were undertaken face-to-face or by telephone between December 2016 and May 2018, followed by thematic framework analysis.ResultsIn this study 21 GPs, and 24 patients who did not attend or had cancelled their appointment were interviewed, deriving a range of potential explanations for non-attendance, including: system flaws; GP difficulties with booking appointments; patient difficulties with navigating the appointment system, particularly older patients and those from more deprived areas; patients leading ‘difficult lives’; and patients’ expectations of the referral, informed by their beliefs, circumstances, priorities, and the perceived prognosis. GPs recognised the importance of communication with the patient, particularly the need to tailor communication to perceived patient understanding and anxiety. GPs and practices varied in their responses to patient non-attendance, influenced by time pressures and perceptions of patient responsibility.ConclusionFailure to be seen within 2 weeks of urgent referral resulted from a number of patient and provider factors. The urgent referral process in general practice and cancer services should accommodate patient perceptions and responses, facilitate referral and attendance, and enable responses to patient non-attendance.
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Hopkins, Rhian, Sarah ER Bailey, William T. Hamilton, and Elizabeth A. Shephard. "Microcytosis as a risk marker of cancer in primary care: a cohort study using electronic patient records." British Journal of General Practice 70, no. 696 (2020): e457-e462. http://dx.doi.org/10.3399/bjgp20x709577.

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BackgroundMicrocytosis (smaller than normal red blood cells) has previously been identified as a possible early risk marker for some cancers. However, the role of microcytosis across all cancers has not been fully investigated.AimTo examine cancer incidence in a cohort of patients with microcytosis, with and without accompanying anaemia.Design and settingCohort study of patients aged ≥40 years using UK primary care electronic patient records.MethodThe 1-year cancer incidence was compared between cohorts of patients with a mean red cell volume of <85 femtolitres (fL) (low) or 85–101 fL (normal). Further analyses examined sex, age group, cancer site, and haemoglobin values.ResultsOf 12 289 patients with microcytosis, 497 had a new cancer diagnosis within 1 year (4.0%, 95% confidence interval [CI] = 3.7 to 4.4), compared with 1465 of 73 150 without microcytosis (2.0%, CI = 1.9 to 2.1). In males, 298 out of 4800 with microcytosis were diagnosed with cancer (6.2%, CI = 5.5 to 6.9), compared with 940 out of 34 653 without (2.7%, CI = 2.5 to 2.9). In females with microcytosis, 199 out of 7489 were diagnosed with cancer (2.7%, CI = 2.3 to 3.1), compared with 525 out of 38 497 without (1.4%, CI = 1.3 to 1.5). In patients with microcytosis but normal haemoglobin, 86 out of 2637 males (3.3%, CI = 2.6 to 4.0) and 101 out of 5055 females (2.0%, CI = 1.6 to 2.4) were diagnosed with cancer.ConclusionMicrocytosis is a predictor of underlying cancer even if haemoglobin is normal. Although a benign explanation is more likely, clinicians in primary care should consider simple testing for cancer on encountering unexplained microcytosis, particularly in males.
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Williams, Pauline, Peter Murchie, and Christine Bond. "Patient and primary care delays in the diagnostic pathway of gynaecological cancers: a systematic review of influencing factors." British Journal of General Practice 69, no. 679 (2019): e106-e111. http://dx.doi.org/10.3399/bjgp19x700781.

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BackgroundGynaecological cancers are the second most common female cancer type, with survival rates in the UK lower than in many comparable countries. A potentially important factor in the UK’s poorer cancer outcomes is diagnostic delay; gynaecological cancers are the cancer type most likely to be affected by less timely diagnosis.AimTo examine current evidence for factors that contribute to patient and primary care delays in the diagnostic pathway of gynaecological cancer.Design and settingA systematic review of the available literature.MethodPRISMA guidelines were followed. MEDLINE and Embase databases and the Cochrane Library were searched using three terms: primary care; gynaecological cancer; and delay. Citation lists of all identified articles were searched. Two authors independently screened the titles, abstracts, and full texts of publications. Data extraction was performed by one author and quality assured by a second reviewer in a 20% sample of selected articles. Synthesis was narrative.ResultsA total of 1253 references was identified, of which 37 met the inclusion criteria. Factors associated with delayed diagnosis were categorised as either patient factors (patient demographics, symptoms or knowledge, and presentation to the GP) or primary care factors (doctor factors: patient demographics, symptoms or knowledge, and referral process); and system factors (such as limited access to investigations).ConclusionDelayed diagnosis in the patient and primary care intervals of the diagnostic journey of gynaecological cancer is complex and multifactorial. This review identifies areas of future research that could lead to interventions to enable prompter diagnosis of gynaecological cancers.
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Wulandari, Sarah Kartika, Yanti Hermayanti, Ahmad Yamin, and Ferry Efendi. "Family Process with Breast Cancer Patient in Indonesia." Jurnal Ners 12, no. 2 (2017): 180. http://dx.doi.org/10.20473/jn.v12i2.5970.

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Introduction: Breast cancer occupies the first position in Asia’s women cancer cases in recent years. Signs and symptoms experienced by the patient affect the stress condition of the patient as well as the family as a caregiver. The condition changes to deal with problems during patient assistance as a major problem in an outpatient setting. The demands of adaptation to through the needs during the period of assistance by the family is more complex. The study aimed to determine the experience of stress and adaptation of breast cancer patient’s family. Methods: The qualitative method used with in-depth interviews on seven respondents who were the family caregiver of breast cancer patients. Setting carried out at the shelter house in Bandung. The analysis process used thematic analysis based on Braun & Clarke. Results: The results found five main themes are: 1) Stressor on breast cancer patients, 2) Crisis fulfillment of companion needs, 3) Crisis accompaniment, 4) Coping mechanisms of caregiver, and 5) Ability in adaptation. Conclusions: Family experience in assisting breast cancer patients who undergo outpatient also impact families tension who traversed with a subjective effort optimally to adapt in accompanying patients and the needs of other resource support system. Suggestions for future step are early recognition of stress by health workers especially nurses to be able to provide targeted interventions to develop positive adaptation to clients. The development through research is needed in applying family center care both the outpatient and inpatient care in an integrated manner.
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Dissertations / Theses on the topic "Family cancer patient"

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Slipkovich, Debbie. "Development of a Patient and Family Educational Document Following Cancer Treatment." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/3072.

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New pharmacological interventions for oncology patients have resulted in longer lifespans after treatment completion and a large population of cancer survivors in communities. When patients complete treatment regimens for cancer, they leave the oncology practice with minimal knowledge of community resources that may assist them during this time of transition. These patients may not interact with care providers again until they return for a surveillance appointment in the future. Guided by Bandura's social cognitive theory, this project's aim was to develop a community-specific brochure that described the variety of services available to oncology patients and their families. The practice-focused question that steered this project asked if the developed patient education brochure on community specific resources was easy to understand and if it contained information pertinent to the oncology population. A comprehensive review of community-based resources was undertaken and placed into a brochure for the cancer survivor sand their families. Eleven participants, oncology nurse practitioners, and chemotherapy infusion nurses from the local outpatient community clinical practice were invited to be content experts. They each reviewed the brochure using the Patient Education Materials Assessment Tool for Printable Materials reporting 100% satisfaction with the content and applicability for the intended patient population. This project promotes social change by providing easy-to-understand transitional care informational for cancer survivors using a community-based brochure approach in a practice setting.
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Rankin, Sandra Renee. "Influence of Coping Styles on Social Support Seeking Among Cancer Patient Family Caregivers." ScholarWorks, 2011. https://scholarworks.waldenu.edu/dissertations/908.

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Family caregivers of cancer patients may enter a predeath grief cycle when their loved one is diagnosed with cancer. The emotional upheaval and accompanying stress that define predeath grief may lead to health problems for the caregiver, and also interfere with their ability to provide care for their loved one. The purpose of the present research was to examine the relationship between coping styles of family caregivers and the tendency of those caregivers to seek social support during active caregiving. This study employed a quantitative approach based on the revised coping theory and the process of bereavement, which is grounded in the transactional theory of stress and coping, to examine coping styles of family members who care for cancer patients. Family caregivers of current cancer patients (n=103) were recruited through e-mails, flyers, the Walden Participant Pool, public social networking sites, and websites to complete the Ways of Coping Questionnaire. A preliminary analysis indicated a normal data distribution and confirmed homoscedasticity and linearity. Through the use of multiple regression, correlations, and t tests, relationships between 7 coping styles and the tendency to seek support were explored. Results indicated that coping styles of confrontive coping, problem solving, and positive reappraisal were positive and significant predictors of the tendency to seek social support during active caregiving. However, coping styles of distancing, self-control, escape/avoidance, and taking responsibility were not significant predictors of seeking social support. Findings from this study can influence social change by promoting appropriate support interventions that appeal to family caregivers, regardless of their coping styles, in order to effectively support the physical and mental health of the caregiver population.
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Human, Carine. "The psychosocial experiences of the patient and family of skin cancer diagnosis and treatment." Diss., University of Pretoria, 2015. http://hdl.handle.net/2263/53411.

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Skin cancer is the most common cancer in South Africa with about 20 000 reported cases every year and 700 deaths. The Cancer Association of South Africa (CANSA) urges all South Africans to be SunSmart to reduce the high incidence of skin cancer in the country. The World Health Organization (2014) reports that between two and three million non-melanoma skin cancers and approximately 132 000 malignant melanomas occur globally every year. South Africa has the second highest incidence of skin cancer in the world after Australia (CANSA, 2014). Skin cancer is an increasing phenomenon in South Africa and enough is not done to raise awareness. The researcher has a very personal interest in skin cancer, the emotions around it, the needs, thoughts and experiences of patients diagnosed with skin cancer, due to various family members having suffered skin cancer. The researcher also learnt through own experience that there is a lack of support systems for the traumatised family to fall back on, specifically when it comes to skin cancer. Individuals who wish to support the patient may also need education, support and information regarding the condition in order to do so. The latter was confirmed through consultations with a Dermatologist and a Plastic Surgeon with regards to the emotional effects of skin cancer. Both specialists expressed eagerness to learn more in this regard and committed to assist the researcher in this study in finding suitable participants, who were selected and interviewed. It was clear from the first interview that none of the participants had expected skin cancer and many emotions were expressed. When a person is diagnosed with skin cancer he or she will often experience anxiety which can be very severe. Anxiety may make the pain experienced by cancer sufferers worse. Anxiety is a normal response to stressful events and is part of the process of coming to terms with an illness. Fear of the unknown is often a significant cause of anxiety. Patients may feel less anxious when they are given more information about their illness and their treatment, or when they find out more from booklets available from cancer charities and patient groups or from websites. Patients also usually begin to feel less anxious as they become more accustomed to seeing the doctor and going to hospitals. As they get to know hospital staff they gradually feel more at ease and less threatened by fears of the unknown. (Gillie, 2005:42). The patient participants had some form of treatment for skin cancer. Various emotions and experiences were observed and expressed by both patient and family participants and it became evident that from diagnosis, through treatment and even post treatment, the participants had a lot of emotions and each phase brought along its own experiences, feelings and needs. This supported theory around the issue of skin cancer and the experience around it being studied. The emotional effects of cancer may last long after the end of treatment. People often find they continue to feel anxious about minor signs of illness or pain, fearing a recurrence. Regular check-ups may be necessary and these can be very scary times. Permanent changes in lifestyle, as a result of cancer, or bodily changes may be daily reminders of the cancer and cause sadness. As distressing as these emotions may be, they are natural reactions to a cancer diagnosis. Talking to family and friends may be helpful (The Cancer Council of New South Wales Coping with Cancer (2005:1). The researcher followed a qualitative approach in this study and attempted to understand the subjective life experience of the participants who suffer from skin cancer and have been diagnosed and undergone treatment. In order to add to the development of insight and a better understanding of the experiences skin cancer patients have in the current South African context, the researcher was able to obtain first-hand information through the use of unstructured interviews as it allowed the participants to share their thought and feelings and experience without guidance from the researcher. The information gathered was in the form of words and concepts, which gave meaning to the participants experiences of a skin cancer diagnosis and treatment. In total 13 participants were selected as part of the study, who included both skin cancer patients and family members. These participants were selected from existing patients and family members of patients of two private medical specialists in Panorama, Parow and Cape Town. Unstructured interviews were conducted with the participants and were voice recorded with their permission. These interviews were then transcribed. The data was then analysed by the researcher and from that, themes and sub-themes were identified. The research findings are presented by the biological profile of all the participants being portrayed and a thematic analysis of the themes and sub-themes. Literature and verbatim quotes were then given in support of the findings. Five themes were identified as follows: Theme 1: Lack of knowledge around skin cancer Theme 2: Reaction to diagnosis Theme 3: Treatment Theme 4: Post-diagnosis mindfulness and behaviour change and Theme 5: Support structures. Each theme had sub-themes which were also discussed. In conclusion, it was eminent that skin cancer patients and their family go through a lot of emotional turmoil and therefore it is of vital importance that the medical personnel or the multi-disciplinary team is aware of this when working with skin cancer patients. It was clear that at the point of diagnosis, patients and their families experience a lot of shock and disbelief which they have to work through. Some even have immediate fears of death, whereas others are oblivious of the severity of the condition. It was mentioned as a need from participants, but also noted in theory that knowledge or a good understanding of a condition and of the treatment lowers anxiety levels. All members of the multi-disciplinary team should ideally be aware and motivated to ensure patients emotional needs are identified and addressed. Social workers have a vital role to play as their skills to identify needs are highly developed and have a good understanding of the family as a support system, as well as connecting patients and families with support systems within their environment and community.<br>Mini Dissertation (MSW)--University of Pretoria, 2015.<br>Social Work and Criminology<br>MSW<br>Unrestricted
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Dunne, Kathleen. "District nurses' experience of providing palliative care for the patient with cancer and his family." Thesis, Ulster University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246894.

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Bernard, Lori Lynn. "Husband's and Daughter's Role Strain During Breast Cancer Hospice Patient Caregiving and Bereavement Adjustment." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2542/.

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Current literature regarding caregiver bereavement adjustment has advanced two competing models explaining adjustment in relation to caregiver interrole conflict: the Relief Model and Complicated Grief Model. This research has primarily focused on the experience of those providing care to dementia patients. This study tests these competing models of bereavement adjustment for husband and daughter caregivers of breast cancer hospice patients. For husbands, greater psychological strain and health strain were predictive of greater difficulty with bereavement adjustment, supporting the Complicated Grief Model of bereavement adjustment. For daughters, strain was not a significant predictor of bereavement adjustment, and thus did not support either bereavement adjustment model. While daughter caregivers experienced more role strain than husband caregivers during patient care, the degree of role strain was predictive of bereavement adjustment for husbands but not for daughters, suggesting that relationship type (husbands versus daughters) between caregiver and patient impacts which factors influence bereavement adjustment.
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Andreassen, Sissel. "Life situation, information needs, and information seeking in patients with oesophageal cancer and their family members/." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-827-4/.

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Andermann, Anne Adina Judith. "Patient education, risk communication and informed choice : women with a family history of breast cancer who present to primary care." Thesis, University of Oxford, 2000. http://ora.ox.ac.uk/objects/uuid:37490745-91a4-4472-aa60-71ca9e0592ba.

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This thesis describes research carried out to explore the needs, expectations and experiences of the increasing number of women with a family history of breast cancer who present to primary care. This work was intended to inform clinical practice and policy, and to directly address women's needs where possible. Although a great deal of research has looked at the experiences of women with a family history of breast cancer in a specialist setting, when this work began, no research had yet been published on women's needs in primary care. This is particularly important, as general practitioners (GPs) are the first port of call, and often the main source of information, advice and support. A qualitative interview study was used for the preliminary work exploring women's subjective experiences of consulting primary care about a family history of breast cancer and understanding their primary care consultation needs (Chapter 2). This work was further elaborated upon using a prospective descriptive study to quantify the extent to which women shared the same views or experiences, and therefore, would benefit from certain changes in health care provision (Chapter 3). The qualitative and quantitative research showed that women's main primary care consultation needs were to discuss their risks of breast cancer with their GP and to receive verbal as well as take-home information. When this work was being carried out, no patient information was available suitable for a general population of women with breast cancer in the family who present to primary care. For this reason, a leaflet was developed based on women's information needs and the best available evidence (Chapter 4). The leaflet entitled Breast and/or Ovarian Cancer in the Family: Learning More about Your Risks and Options was evaluated with almost 200 women to ensure that it met their needs (Chapter 5). Over 90% of women were glad to have received the leaflet and felt that it provided the information they wanted to know. The implications of the work described in this thesis are that GPs could greatly assist their patients by acknowledging family history concerns as a legitimate reason for presenting to primary care, by providing verbal and take-home information and by inviting patients to return for future discussions if needed. Nationally accepted management guidelines for breast cancer family history and accompanying educational materials for use in primary care will also be instrumental in meeting patient needs and promoting informed choice in this new and difficult area of medicine.
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Eaton, Bill. "Symptoms of patients hospitalized because of malignancy : a comparison of the perceptions of the patient, the next of kin, and the nurse /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0005/MQ42371.pdf.

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Friedrichsen, Maria. "Crossing the border : Different ways cancer patients, family members and physicians experience information in the transition to the late palliative phase." Doctoral thesis, Linköping : Univ, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5231.

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Cavalli-Björkman, Nina. "Factors Influencing Selection of Treatment for Colorectal Cancer Patients." Doctoral thesis, Uppsala universitet, Enheten för onkologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172533.

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In Sweden and elsewhere there is evidence of poorer cancer survival for patients of low socioeconomic status (SES), and in some settings differences in treatment by SES have been shown. The aim of this thesis was to explore factors which influence cancer treatment decisions, such as knowledge reaped from clinical trials, patient-related factors, and physician-related factors. In a register study of colorectal cancer, all stages, patients were stratified for SES-factors. Differences were seen with regards to clinical investigation, surgical and oncological treatment and survival, with the highly educated group being favored. Survival was better for highly educated patients in stages I, II and III but not in stage IV. In a Scandinavian cohort of newly metastasized colorectal cancer patients, recruitment to clinical trials was studied. Patients entering clinical trials had better performance status and fewer cancer symptoms than those who were treated with chemotherapy outside of a clinical trial. Median survival was 21.3 months for trial-patients and 15.2 months for those treated with chemotherapy outside a  trial. Those not treated with chemotherapy had a median survival of just 2.1 months. Patients in clinical trials are highly selected and conclusions drawn from studies cannot be applied to all patients. In the same cohort, treatment and survival were stratified for education, smoking and indicators of social structure. Highly educated patients did not have a survival advantage. Patients who lived alone were offered less combination chemotherapy and surgery of metastases than other patients and had 4 months shorter survival than those who lived with a spouse or child. In a fourth study, 20 Swedish gastrointestinal oncologists were interviewed on which factors they considered when deciding on oncological treatment. Oncologists feared chemotherapy complications due to lack of social support, and ordered less combination chemotherapy for patients living alone. Highly educated patients were seen as well-read and demanding, and giving in to these patients’ requests for treatment was regarded as a way of pleasing patients and relatives and of avoiding conflict.
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Books on the topic "Family cancer patient"

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Anderson, Laurie Smith. The patient person: [a woman and her family confront cancer]. Capital City Press, 2007.

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Andrew, Blitzer, ed. Communicating with cancer patients and their families. Charles Press, 1990.

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Robert, DeBellis, ed. Psychosocial aspects of chemotherapy in cancer care: The patient, family, and staff. Haworth Press, 1987.

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Stone, Barbara. Cancer as initiation: Surviving the fire : a guide for living with cancer for patient, provider, spouse, family, or friend. Open Court, 1994.

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Logan, Marion. Continuous subcutaneous infusion of narcotics: Patient care and family support ; guide for CSCI nurses. University of Ottawa Press, 1991.

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Zhou, Xixian. Yi wan yang chun mian de hui yi. Shanxi shi fan da xue chu ban she, 2008.

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Zhou, Xixian. Yi wan yang chun mian de hui yi. Shanxi shi fan da xue chu ban she, 2008.

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Dunne, Kathleen. District nurses' experience of providing palliative care for the patient with cancer and his family. The Author], 2002.

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C, McNally Joan, Somerville Eileen T, Stair Joy Campbell, Oncology Nursing Society. Clinical Practice Committee. Subcommittee on Guidelines., and Oncology Nursing Society, eds. Guidelines for nursing care of patients and families living with cancer. Grune & Stratton, 1985.

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M, Wilkes Gail, Ingwersen Karen, and Barton-Burke Margaret, eds. Cancer chemotherapy care plans. 2nd ed. Jones and Bartlett Publishers, 1998.

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Book chapters on the topic "Family cancer patient"

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Capra, L. G. "The Care of the Patient and Family." In The Care of the Cancer Patient. Macmillan Education UK, 1986. http://dx.doi.org/10.1007/978-1-349-18386-9_24.

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Marmor, Judd. "The Cancer Patient and His Family (1963)." In Psychiatry in Transition, 2nd ed. Routledge, 2021. http://dx.doi.org/10.4324/9780429338397-6.

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Durante, Cosimo, Fabiana Trulli, and Sebastiano Filetti. "A Young Patient with Intrathyroidal Papillary Thyroid Cancer and Family History of Differentiated Thyroid Cancer." In Thyroid Cancer. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-22401-5_11.

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Grani, Giorgio, Valeria Ramundo, and Cosimo Durante. "A Young Patient with Intrathyroidal Papillary Thyroid Cancer and Family History of Differentiated Thyroid Cancer." In Thyroid Cancer. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-61919-0_2.

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Schnaper, Nathan, and Tamar Koren Kellner. "Psychosocial Effect of Cancer on the Patient and the Family." In Head and Neck Management of the Cancer Patient. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2289-4_25.

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Shoemaker, Laura, and Susan McInnes. "Starting a Palliative Care Program at a Cancer Center." In The Comprehensive Cancer Center. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82052-7_12.

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AbstractPalliative care is now considered an integral component in the provision of comprehensive cancer care services, from diagnosis to treatment to ultimate recovery or death. High-quality evidence in the setting of both solid tumors and hematologic malignancies suggests that incorporation of palliative care is associated with higher quality care, greater patient and family satisfaction, improved clinician experience, more appropriate healthcare resource utilization, and better patient outcomes, including survival. Strategic investment, staffing, and support for a palliative care program also makes cancer care patient-centric and cost-effective. This chapter provides pragmatic guidance on setting up a palliative care program within a cancer center and discusses strategies and opportunities for early and late planning, launch of the program and its integration within other cancer services, making it sustainable, monitoring outcomes and quality, and using it as a platform for research.
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Kilic, Mustafa. "Wound Care in Cancer Patients." In Oncological Rehabilitation a Handbook for Healthcare Professionals. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358893.8.

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Cancer treatment can cause various skin and mucosa injuries. These injuries, which seriously reduce the quality of life of patients, should be well identified, evaluated, treated and necessary protective measures taken by healthcare professionals. Having a standardized wound assessment tool ensures consistent and accurate transfer of information among healthcare providers. To provide infection control, it is important to select appropriate antibiotic agents and appropriate antimicrobial dressins or solutions. They should be able to use evidence-based practices in wound care. In addition to all these physiological interventions, it should be able to offer interventions to solve the psychosocial problems that the wound may cause on the patient and his family.
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Efiloglu, Ozgur, and Ayberk Iplikci. "Radiotherapy As a Local Therapy in the Management of Patient with Oligometastatic Prostate Cancer." In Current Management of Metastatic Prostate Cancer. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359142.5.

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Alcohol use in adolescents is influenced by various hereditary, environmental, social, and psychological factors. This period is critical for brain development, with changes in the reward system leading to increased novelty-seeking and risk-taking behaviors. Early initiation of alcohol use can lead to long-term consequences, including addiction, comorbid psychiatric disorders, academic problems, and social issues. Risk factors include a family history of substance use, male gender, traumatic experiences, and weak parental control. Despite lower substance use rates compared to Europe, alcohol use in Turkey is rising. Effective interventions include early prevention, psychosocial treatments, and complementary therapies like music and animal-assisted therapy.
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Driedger, S. Michelle, Elizabeth J. Cooper, and Ryan Maier. "Balancing Shared Decision-Making with Population-Based Recommendations: A Policy Perspective of PSA Testing and Mammography Screening." In Democratizing Risk Governance. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-24271-7_10.

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AbstractPopulation-based screening programs invite otherwise healthy people who are not experiencing any symptoms to be screened for cancer. In the case of breast cancer, mammography screening programs are not intended for higher risk groups, such as women with family history of breast cancer or carriers of specific gene mutations, as these women would receive diagnostic mammograms. In the case of prostate cancer, there are no population-based screening programs available, but considerable access and use of opportunistic testing. Opportunistic testing refers to physicians routinely ordering a PSA test or men requesting it at time of annual appointments. Conversations between patients and their physicians about the benefits and harms of screening/testing are strongly encouraged to support shared decision-making. There are several issues that make this risk scenario contentious: cancer carries a cultural dimension as a ‘dread disease’; population-based screening programs focus on recommendations based on aggregated evidence, which may not align with individual physician and patient values and preferences; mantras that ‘early detection is your best protection’ make public acceptance of shifting guidelines based on periodic reviews of scientific evidence challenging; and while shared decision-making between physicians and patients is strongly encouraged, meaningfully achieving this in practice is difficult. Cross-cutting these tensions is a fundamental question about what role the public ought to play in cancer screening policy.
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Finegan, Wesley C., Angela McGurk, Wilma O’Donnell, Jan Pederson, and Elizabeth Rogerson. "The family as carers." In Care of the Cancer Patient. CRC Press, 2018. http://dx.doi.org/10.4324/9781315378527-53.

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Conference papers on the topic "Family cancer patient"

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Gee, A. P. "Hematopoietic Stem Cell Engineering: The Magic Bullet of the Next Millenium?" In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-1317.

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Abstract Hematopoietic stem cell [HSC] therapy has its origins as hematological rescue following marrow ablative high-dose therapy for refractory cancers and myelodysplastic syndromes. In its simplest form, bone marrow is collected from a tissue-matched related normal donor and intravenously infused into the patient who has usually received high-dose chemo/radiotherapy for his or her disease. The stem cells migrate to the marrow spaces, where they multiply and differentiate to restore blood cell-forming activity and immune defenses in the recipient Restrictions in the availability of tissue-matched marrow donors have prompted investigations into new sources of stem cells. These include use of the autologous marrow, which is collected from the patient and cryopreserved prior to therapy. The risk of tumor contamination in these grafts has resulted in the development of numerous methods to purge cancer cells from marrow ex vivo, or to enrich stem cells from the graft. This provided one of the earliest clinical applications for monoclonal antibodies and immunomagnetic cell separation. Another approach has been to use tissue-matched unrelated volunteer marrow donors, or grafts from mismatched family members. In both cases, ex vivo removal of T lymphocytes from the graft is advisable to prevent these cells initiating a severe or fatal reaction in the recipient - graft-versus-host disease. Recent studies have shown that recombinant human growth factors can be used to stimulate migration of HSC from the marrow into the blood, from which they are collected by automated cell separators, obviating the need for harvesting marrow under general anesthesia. The same growth factors have been used to expand and differentiate HSC ex vivo, with the hope that clinical grafts could ultimately be grown in the laboratory from a few milliliters of blood or marrow. Transplants have also been performed using placental/umbilical cord blood as the HSC source, and there are some indications that these cells may be more suitable for mismatched transplants. Genetic manipulation of stem cells can be used to correct a number of inherited diseases, and ultimately may allow specific beneficial properties to be introduced into blood-derived cells e.g. drug resistance into stem cells - to allow higher doses of chemotherapy to be used without destroying the bone marrow. The rapid expansion in this field of medicine, combined with advances in molecular and cellular biology offer the promise of stem cell engineering as an effective therapy in a variety of diseases.
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"Case series: Breast and ovarian cancer syndrome." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685364.

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Aims and Objectives: To report a series of cases with breast and ovarian carcinomas either in same patient or in a family and identifying the importance of BRCA 1, 2 genetic testing in such individuals. Materials and Methods: The medical records of breast and ovarian cancer patients operated over past 3 years at a single institute were reviewed retrospectively and their clinical profile, family history, final pathological reports and follow up data was collected. Results: 8 patients were found to have breast and ovarian malignancies, out of which 3 had synchronous breast and ovarian cancers, 4 had metachronous and 1 patient with ovarian cancer had history of breast cancer in family. Median age of presentation to the hospital was 47 years and median time interval in metachronous disease patients was 5.5 years. Conclusion: About 5% of people who have breast cancer and about 10% of women who have ovarian cancer have HBOC, caused by germline mutation in BRCA 1, 2 gene. These individuals have increased risk of developing breast cancer at younger age, TNBC, or developing a second primary in breast or ovary plus an overall risk of breast/ovarian/prostate/pancreatic malignancies in other family members due to inheritable mutation. Identification of BRCA mutation in such individuals can help family members to undergo genetic counseling and follow different screening and prevention guidelines from general population thus reducing the cancer risks.
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"Case series: Breast and ovarian cancer syndrome." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685348.

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Aims and Objectives: To report a series of cases with breast and ovarian carcinomas either in same patient or in a family and identifying the importance of BRCA 1,2 genetic testing in such individuals. Materials and Methods: The medical records of breast and ovarian cancer patients operated over past 3 years at a single institute were reviewed retrospectively and their clinical profile, family history, final pathological reports and follow up data was collected. Results: 8 patients were found to have breast and ovarian malignancies, out of which 3 had synchronous breast and ovarian cancers, 4 had metachronous and 1 patient with ovarian cancer had history of breast cancer in family. Median age of presentation to the hospital was 47 years and median time interval in metachronous disease patients was 5.5 years. Conclusion: About 5% of people who have breast cancer and about 10% of women who have ovarian cancer have HBOC, caused by germline mutation in BRCA1, 2 gene. These individuals have increased risk of developing breast cancer at younger age, TNBC, or developing a second primary in breast or ovary plus an overall risk of breast/ovarian/prostate/pancreatic malignancies in other family members due to inheritable mutation. Identification of BRCA mutation in such individuals can help family members to undergo genetic counseling and follow different screening and prevention guidelines from general population thus reducing the cancer risks.
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Feijão, Maria Clara Tomaz, Fernanda Pimentel Arraes Maia, Mateus Coelho Gondim de Oliveira Lima, Vitória Moreira Soares, and Luiz Gonzaga Porto Pinheiro. "CONCERNING A FAMILY WITH BRCA2 MUTATION." In XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1019.

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Introduction: Breast cancer is the most common malignancy in women and represents a major obstacle to public health worldwide. The molecular diagnosis of this type of cancer is one of the main contemporary challenges in oncology, since it is hampered by a complex inheritance pattern, characterized by both genetic and environmental factors. Only a minority of breast cancers are explained by the presence of high penetrance gene mutations, such as those in the BRCA1 and BRCA2 genes, which together with mutations in intermediate penetrance genes explain only up to 25% of the risk. In fact, much of the genetic influence is elucidated by low penetrance variants. Mutations in the germline BRCA1 and BRCA2 are the most common alterations in cases of early onset or of family history of breast cancer. It is also important to acknowledge that BRCA2 mutations can increase the risk of developing other cancers. Some studies show a relation between BRCA2 mutations and the development of leukemia, especially acute myeloid leukemia (AML). Also, some of these mutations, when inherited from both parents, cause a rare form of Fanconi anemia, a syndrome associated with the development of AML. In addition, there are studies evaluating a higher risk of pancreatic and esophageal cancer in carriers of BRCA2 mutations. The risk of colorectal cancer is also increased in patients with BRCA1 mutations. However, there are also some authors who defend that BRCA2 mutations could also be related. The specific statistics are not well defined because of the lack of data focusing on the relationship with the aforecited types of cancers, demonstrating the need for further analysis. This study aims to report the case of a woman with breast cancer at an early age. Such malignancy is associated and was somehow induced by the rich family history, represented by the high prevalence of cancer in the ancestry. We report a 34-year-old woman with an extensive history of carcinoma in the family, who was diagnosed with breast cancer in July 2016. In order to confirm the diagnosis, it was required an ultrasound, which resulted in a 2.2×1.5 cm node on the right breast’s left superior quadrant, classified as BIRADS 4A. It also performed an ultrasound-guided biopsy that showed a tubular carcinoma on the right breast with the following characteristics: positive for estrogen and progesterone receptor, positive for KI 67 (5%), and negative for HER2, with staging of T1cN0M0. During anamnesis, the patient mentioned menarche at 12 years old, history of birth control pills use for 10 years, no pregnancy, and no breastfeeding. When it comes to family history, a great number of relatives were previously diagnosed with some type of cancer. Her paternal grandfather had rectum cancer at 42 years old and breast cancer at 62 years old. The paternal grandmother passed away because of a fast-progression leukemia at the age of 68. It is important to mention that her progenitors were first cousins. Furthermore, the patient’s dad was diagnosed with breast cancer at 62 years, alongside his three brothers who were also diagnosed with cancer: one with prostatic cancer at the age of 64 years and the other two with intestinal cancer at the ages of 64 and 68 years old. Considering such a family history, a genetic panel was performed, analyzing the genes related to hereditary cancer risk, and it identified mutations in the patient’s BRCA2 gene. Then, firstly, she performed a bilateral mastectomy in January 2017 with sentinel lymph node investigation, which was negative for neoplastic cells in the lymph nodes. Later, considering the BRCA2 mutation, in August 2017, the patient had to undergo prophylactic surgery: oophorectomy with salpingectomy.
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Green, Matthew, Hannah Ngo, Dakota B. Pastore, et al. "Addressing Gaps in Care Through a Medical Student-Led Cancer Screening Project." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. http://dx.doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.35_2024.

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Background: Colorectal cancer (CRC), breast cancer (BrCa), and cervical cancer are three of the most preventable cancers. Despite the known significance for early detection and treatment, barriers to screening remain. We developed a medical student-led project to improve adherence to national cancer screening guidelines in patients across Rowan-Virtua Family Medicine (FM) practices. This study assesses the initiative’s efficacy in improving adherence to CRC, BrCa, and cervical cancer screenings. Methods: Rowan-Virtua FM patients between the ages of 21-75 (n=735) were identified as due or up-to-date on cancer screenings based on chart review. Student volunteers were trained to contact patients to discuss options for overdue screenings and place corresponding referrals. Patient demographics including sex, age, and race/ethnicity were collected. Outcomes included patient eligibility, number and rates of patients reached, referrals placed, and up-to-date patients. Results: Among the 735 patients, mean (sd) age was 57.9 (11.5), 71.2% were female, 55.8% were white, 15.5% were Black, 4.4% were Hispanic, 1.4% were Asian and 23.4% did not specify their race/ethnicity. Per chart review, 643 (87.5%) patients were due for at least one cancer screening. Of 323 (50.2%) patients reached via phone, 30.7% received at least one referral for cancer screening, 23.2% reported being up-to-date on screenings, and 46.1% declined screening. A total of 28 colonoscopy, 38 stool DNA test, 38 mammogram, and 30 pap smear referrals were placed among 99 patients. 28 patients received referrals for more than one screening. Conclusion: This student-led medical outreach project promoted increased adherence to national cancer screening guidelines.
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Rocha, Marina Elias, Isabella Ferreira Bonifácio, João Pedro Sia Borges, Lara da Cruz Encinas Brandão, and Wilson Marques da Silveira Neto. "The influence of social skills in the humanization of breast cancer care." In Brazilian Breast Cancer Symposium 2024. Mastology, 2024. http://dx.doi.org/10.29289/259453942024v34s1106.

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Objective: This study aimed to analyze how social skills can influence the care of patients with breast cancer, in order to create humanized care. Methodology: A bibliographical survey of the last 6 years was carried out in the PubMed and VHL virtual libraries, and articles related to this topic were also selected. Results: Breast cancer is more prevalent among women, causing different biological and psychological changes in a unique way in each patient. These changes require a holistic approach to care, which is capable of addressing not only the physical aspects of the illness but also the biopsychosocial, spiritual, and family conditions that directly interfere with the course of women’s treatment and recovery. Part of these essential factors is family support, together with the multidisciplinary team, which plays an essential role in this context, developing emotional assistance that contributes considerably to the well-being and quality of life of patients. In this way, it is possible to promote a broad support network that involves professionals and family members who contribute substantially to a humanized care practice. Studies have shown that empathetic care, touch, welcoming, and qualified listening are examples of social skills, which, combined with assistance to patients with breast cancer, promote humanization and comprehensiveness of care. In this way, the results showed safer and more confident patients, with greater adherence to treatment, reducing fears and negative apprehensions regarding the disease. In this sense, this approach has proven to be efficient, especially in Brazilian public health demands, providing more complete, humane, and ethical care. Conclusion: In this sense, social skills improve care, contributing to improving the quality of life of breast cancer patients by providing a comprehensive look at each patient and addressing their different aspects.
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Peixoto, Yêda Maria Silva, Márcia de Faria Veloso, and Ruffo Freitas-Júnior. "EXPERIENCE REPORT OF PSYCHOSOCIAL CARE TO A PATIENT WITH BREAST CANCER." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2061.

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Introduction: This study presents the experience of psychological care to women with breast cancer, attended at the Advanced Breast Diagnosis Center (CORA), Hospital das Clínicas – UFG, under supervision. Objective: The aim of this study is to describe the phases of greatest psychosocial impact in the treatment of patients and family members. Methodology: The service to EAS was started in November 2017 after, 43 years old, divorced, and provider of three minor children, receiving the diagnosis of phylloid tumor, intense anguish, fear of death, emotional lability, conflicts family and socioeconomic status, presenting a distorted perception of identity. She was mastectomized and underwent chemotherapy and a new surgery in 2018, after a recurrence of sarcoma in the sternum bone, at which point she went into palliative care. Psychological, digital, and social-technical resources were used until her death in May 2020. Results: An improvement was observed in the coping strategy, resolution of family conflicts, recovery of affective bonds and their identity, with the distribution of tasks of the children, and improvement of the family dialogue, including the desire to grant the guardianship of the children to her brother. Discussion: It is necessary to have a systemic look at the patient who arrives at the public hospital. Considerations: This experience was enriching due to the relevance of the role of psychology and its interventions with the multidisciplinary team, promoting a significant improvement in the psychological well-being and quality of life of the patient who arrives with real and imagined suffering aggravated by the disease and treatment.
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Silva, Paula Francinete Faustino da, Rebeca Mota Goveia, Thais Bomfim Teixeira, et al. "EARLY-ONSET BREAST CANCER PATIENTS FULFILLING HEREDITARY BREAST AND OVARY CANCER AND LI-FRAUMENI-LIKE SYNDROMES CAN HARBOR TP53 PATHOGENIC VARIANTS." In Brazilian Breast Cancer Symposium 2022. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s2018.

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Objective: We investigate the prevalence of TP53 germline pathogenic variants in a cohort of 83 breast cancer patients and 217 family members from the Midwest Brazilian region. Methods: All patients met the clinical criteria for hereditary breast and ovarian cancer syndrome (HBOC) and were negative for BRCA1 and BRCA2 mutations. Moreover, 40 index patients fulfilled HBOC and the Li-Fraumeni-like syndromes (LFL) criteria. The samples were tested using next-generation sequencing for TP53. Results: Three patients harbored TP53 missense pathogenic variants (p.Arg248Gln, p.Arg337His, and p.Arg337Cys), confirmed by Sanger sequencing. One patient showed a large TP53 deletion (exons 2–11), which was also confirmed. The p.R337H variant was detected in only one patient. Conclusion: This study concluded that 4 out of 83 HBOC and LFL patients presented TP53 pathogenic variants at a young age. In contrast to other Brazilian regions, the TP53 p.R337H variant appeared with low prevalence.
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Carvalho, Débora Medeiros de, Josielly Ferreira Bacelar, Joarla Ayres de Morais Estevão, et al. "Two pathogenic variants in a patient with cervical and breast cancer: Case report." In Brazilian Breast Cancer Symposium 2023. Mastology, 2023. http://dx.doi.org/10.29289/259453942023v33s1054.

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Introduction: The presence of two pathogenic germline variants in hereditary cancer is an uncommon event. We report a case of a Brazilian patient from Teresina, Piauí, who developed breast and cervical carcinoma with pathogenic variants in BRCA2 and MUTYH genes. Case Report: A 25-year-old female patient in 2012 underwent a radical hysterectomy with pelvic lymphadenectomy without ovarian preservation for treatment of histologic grade 2 (G2) squamous cell carcinoma (SCC) of the cervix, FIGO stage IB2. Histopathology of the surgical specimen revealed SCC, G2, stromal invasion 16 mm, 4.5 cm in diameter, compromised parametrium, 6 lymph nodes without metastasis, and normal ovaries. She received pelvic radiotherapy and brachytherapy associated with platinum-based chemotherapy. In 2017, she was diagnosed with histologic grade 1 invasive breast carcinoma of no special type in the right breast. Immunohistochemistry revealed that it was a luminal B tumor (estrogen receptor (ER)+ 90%, progesterone receptor (PR) + 80%, human epidermal growth factor (HER2) 1+, Ki-67 40%), stage IA (T1N0M0)). Neoadjuvant chemotherapy with doxorubicin and cyclophosphamide (AC, 4 cycles) followed by paclitaxel (12 cycles) was performed. The patient underwent segmental mastectomy, and sentinel lymph node research and histopathology revealed complete pathological response and negative sentinel lymph node residual cancer burden 0. She had a history of three pregnancies and three deliveries, with no case of neoplasia in the family. In 2023, multigene test for hereditary predisposition to cancer was performed, in which two pathogenic variants were detected being one in BRCA2 gene (c.8725A&gt;T) and the other in MUTYH (c.1187G&gt;A). Currently, there is no evidence of active disease and on schedule for colonoscopy, endoscopy, and bilateral risk-reducing mastectomy. Conclusion: In young patients with multiple cancers, a search for pathogenic variants related to hereditary cancer predisposition syndromes should be offered, as in the present case.
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Souto, Andreza Karine de Barros Almeida, Poliana Bergamaschine Giovani Blasi, Brenda Fabiola Delgado Taboada, Fernanda Teresa Lima, Bernardo Garicochea, and Cristiano Augusto Andrade de Resende. "NEUROENDOCRINE CARCINOMA OF THE BREAST AND ILEUM IN A PATIENT WITH BRCA2 PATHOGENIC VARIANT – ONCOLOGIC AND GENETIC CONSIDERATIONS DERIVED FROM A CASE REPORT." In Brazilian Breast Cancer Symposium 2022. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s2076.

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Background: Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplasms. Most frequently, they occur in the digestive system, and breast neuroendocrine tumors constitute less than 1% of all of them. Germline mutations can increase the risk of developing tumors and predispose to hereditary cancer syndromes. Some NENs are well-established components of common hereditary syndromes. Recently, whole genomic sequencing revealed that 17% of apparently sporadic pancreatic NENs carried germline mutations, including DNA repair genes, such as BRCAs. It is well known that this gene plays a role in hereditary breast cancer, but variations in these genes were not described in patients with breast/ ileum neuroendocrine tumors. We present a patient with a neuroendocrine tumor and a germline pathogenic variant in BRCA2. Case report: A 44-year-old female patient presented with a palpable lesion at the right breast, with 1.1×1.4 cm, and a biopsy confirmed an invasive ductal carcinoma, grade 2. Immunohistochemistry revealed a neuroendocrine breast carcinoma (ER10% PR5%, HER2 negative, Ki-67=8%). The regular staging examinations did not show any abnormalities, but a 68Ga PET/CT demonstrated an ileum wall thickening with a marked expression of somatostatin receptors compatible with primary disease, with mesenteric lymph nodes and hepatic lesions suggestive of metastasis, in addition to the right breast lesion that could be either a secondary implant or a primary synchronic tumor. A detailed family history did not reveal any important cancer cases in the family except for the father and a paternal uncle, both with prostate cancer at 72 and 85 years old, respectively. Germline genetic analysis confirmed the presence of a heterozygous pathogenic variant in BRCA2 (c.2167delA;p.Ser723Alafs*7). The patient is currently being treated with octreotide LAR with good tolerance and stable disease. Final comments: This case shows the importance of molecular germline investigation in patients with NENs. This patient adds knowledge to the association of the BRCA2 gene and neuroendocrine tumors.
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Reports on the topic "Family cancer patient"

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Boyes, Allison, Jamie Bryant, Alix Hall, and Elise Mansfield. Barriers and enablers for older people at risk of and/or living with cancer to accessing timely cancer screening, diagnosis and treatment. The Sax Institute, 2022. http://dx.doi.org/10.57022/ieoy3254.

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• Older adults have complex and unique needs that can influence how and when cancer is diagnosed, the types of treatment that are offered, how well treatment is tolerated and treatment outcomes. • This Evidence Check review identified 41 studies that specifically addressed barriers and enablers to cancer screening, diagnosis and treatment among adults aged 65 years and older. • Question 1: The main barriers for older people at risk of and/or living with cancer to access and participate in timely cancer screening relate to lack of knowledge, fear of cancer, negative beliefs about the consequences of cancer, and hygiene concerns in completing testing. The main enablers to participation in timely cancer screening include positive/helpful beliefs about screening, social influences that encourage participation and knowledge. • Question 2: The main barriers for older people at risk of and/or living with cancer to access and/or seek timely cancer diagnosis relate to lack of knowledge of the signs and symptoms of cancer that are distinct from existing conditions and ageing, healthcare accessibility difficulties, perceived inadequate clinical response from healthcare providers, and harmful patient beliefs about risk factors and signs of cancer. The main enablers to accessing and/or seeking a timely cancer diagnosis include knowledge of the signs and symptoms of cancer, and support from family and friends that encourage help-seeking for symptoms. • Question 3: The main barriers for older people at risk of and/or living with cancer in accessing and completing cancer treatment include discrimination against patients in the form of ageism, lack of knowledge, patient concern about the adverse effects of treatment, predominantly on their independence, healthcare accessibility difficulties including travel and financial burden, and patients’ caring responsibilities. The main enablers to accessing and completing cancer treatment are social support from peers in a similar situation, family and friends, the influence of healthcare providers, and involving patients in treatment decision making. • Implications. The development of strategies to address the inequity of cancer outcomes in people aged 65 years and older in NSW should consider: ­ Increasing community members’ and patients’ knowledge and awareness by providing written information and decision support tools from a trusted source ­ Reducing travel and financial burden by widely disseminating information about existing support schemes and expanding remote patient monitoring and telehealth ­ Improving social support by promoting peer support, and building the support capacity of family carers ­ Addressing ageism by supporting patients in decision making, and disseminating education initiatives about geriatric oncology to healthcare providers ­ Providing interdisciplinary geriatric oncology care by including a geriatrician as part of multidisciplinary teams and/or expanding geriatric oncology clinics.
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Frost, Jennifer J., Mia R. Zolna, Lori F. Frohwirth, et al. Publicly Supported Family Planning Services in the United States: Likely Need, Availability and Impact, 2016. Guttmacher Institute, 2019. http://dx.doi.org/10.1363/2019.30830.

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Key Points Key Points In 2016, 20.6 million U.S. women were likely in need of public support for contraceptive services and supplies. Between 2010 and 2016, the number of women likely in need of public support for contraceptive services and supplies rose 8% overall. Among women below 250% of federal poverty guidelines, there was a 12% increase; among adolescents, there was a 5% decline. Between 2013 and 2016, the number of women likely in need of public support for contraceptive services who had neither public nor private health insurance fell more than one-third (36%), from 5.6 million to 3.6 million. States that implemented the Affordable Care Act’s Medicaid expansion experienced particularly large declines. Between 2010 and 2016, the overall number of women receiving publicly supported contraceptive services remained stable at about nine million women. However, the number of women served by different types of providers shifted dramatically over this period. While Title X–funded sites continued to serve the largest segment of women receiving publicly supported care, their patient load fell by 25%, from 4.7 million in 2010 to 3.5 million in 2016. The number of contraceptive patients served by other public clinics that do not receive Title X funding rose by 29% and the number of women receiving Medicaid-funded contraceptive services from private providers rose by 19%. In 2016, women who obtained contraceptive services from all publicly supported providers were able to postpone or avoid two million pregnancies that they would have been unable to prevent without access to publicly supported care. Women who obtained contraceptives from Title X–funded clinics avoided 755,000 pregnancies. Screening and vaccination services provided at family planning visits with all publicly supported providers helped patients avoid more than 12,000 cases of pelvic inflammatory disease and nearly 2,000 cases of cervical cancer in 2016. More than 100,000 chlamydia infections, 18,000 gonorrhea infections and 800 cases of HIV were prevented among the partners of women obtaining publicly funded contraceptive care.
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3

MacFarlane, Andrew. 2021 medical student essay prize winner - A case of grief. Society for Academic Primary Care, 2021. http://dx.doi.org/10.37361/medstudessay.2021.1.1.

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As a student undertaking a Longitudinal Integrated Clerkship (LIC)1 based in a GP practice in a rural community in the North of Scotland, I have been lucky to be given responsibility and my own clinic lists. Every day I conduct consultations that change my practice: the challenge of clinically applying the theory I have studied, controlling a consultation and efficiently exploring a patient's problems, empathising with and empowering them to play a part in their own care2 – and most difficult I feel – dealing with the vast amount of uncertainty that medicine, and particularly primary care, presents to both clinician and patient. I initially consulted with a lady in her 60s who attended with her husband, complaining of severe lower back pain who was very difficult to assess due to her pain level. Her husband was understandably concerned about the degree of pain she was in. After assessment and discussion with one of the GPs, we agreed some pain relief and a physio assessment in the next few days would be a practical plan. The patient had one red flag, some leg weakness and numbness, which was her ‘normal’ on account of her multiple sclerosis. At the physio assessment a few days later, the physio felt things were worse and some urgent bloods were ordered, unfortunately finding raised cancer and inflammatory markers. A CT scan of the lung found widespread cancer, a later CT of the head after some developing some acute confusion found brain metastases, and a week and a half after presenting to me, the patient sadly died in hospital. While that was all impactful enough on me, it was the follow-up appointment with the husband who attended on the last triage slot of the evening two weeks later that I found completely altered my understanding of grief and the mourning of a loved one. The husband had asked to speak to a Andrew MacFarlane Year 3 ScotGEM Medical Student 2 doctor just to talk about what had happened to his wife. The GP decided that it would be better if he came into the practice - strictly he probably should have been consulted with over the phone due to coronavirus restrictions - but he was asked what he would prefer and he opted to come in. I sat in on the consultation, I had been helping with any examinations the triage doctor needed and I recognised that this was the husband of the lady I had seen a few weeks earlier. He came in and sat down, head lowered, hands fiddling with the zip on his jacket, trying to find what to say. The GP sat, turned so that they were opposite each other with no desk between them - I was seated off to the side, an onlooker, but acknowledged by the patient with a kind nod when he entered the room. The GP asked gently, “How are you doing?” and roughly 30 seconds passed (a long time in a conversation) before the patient spoke. “I just really miss her…” he whispered with great effort, “I don’t understand how this all happened.” Over the next 45 minutes, he spoke about his wife, how much pain she had been in, the rapid deterioration he witnessed, the cancer being found, and cruelly how she had passed away after he had gone home to get some rest after being by her bedside all day in the hospital. He talked about how they had met, how much he missed her, how empty the house felt without her, and asking himself and us how he was meant to move forward with his life. He had a lot of questions for us, and for himself. Had we missed anything – had he missed anything? The GP really just listened for almost the whole consultation, speaking to him gently, reassuring him that this wasn’t his or anyone’s fault. She stated that this was an awful time for him and that what he was feeling was entirely normal and something we will all universally go through. She emphasised that while it wasn’t helpful at the moment, that things would get better over time.3 He was really glad I was there – having shared a consultation with his wife and I – he thanked me emphatically even though I felt like I hadn’t really helped at all. After some tears, frequent moments of silence and a lot of questions, he left having gotten a lot off his chest. “You just have to listen to people, be there for them as they go through things, and answer their questions as best you can” urged my GP as we discussed the case when the patient left. Almost all family caregivers contact their GP with regards to grief and this consultation really made me realise how important an aspect of my practice it will be in the future.4 It has also made me reflect on the emphasis on undergraduate teaching around ‘breaking bad news’ to patients, but nothing taught about when patients are in the process of grieving further down the line.5 The skill Andrew MacFarlane Year 3 ScotGEM Medical Student 3 required to manage a grieving patient is not one limited to general practice. Patients may grieve the loss of function from acute trauma through to chronic illness in all specialties of medicine - in addition to ‘traditional’ grief from loss of family or friends.6 There wasn’t anything ‘medical’ in the consultation, but I came away from it with a real sense of purpose as to why this career is such a privilege. We look after patients so they can spend as much quality time as they are given with their loved ones, and their loved ones are the ones we care for after they are gone. We as doctors are the constant, and we have to meet patients with compassion at their most difficult times – because it is as much a part of the job as the knowledge and the science – and it is the part of us that patients will remember long after they leave our clinic room. Word Count: 993 words References 1. ScotGEM MBChB - Subjects - University of St Andrews [Internet]. [cited 2021 Mar 27]. Available from: https://www.st-andrews.ac.uk/subjects/medicine/scotgem-mbchb/ 2. Shared decision making in realistic medicine: what works - gov.scot [Internet]. [cited 2021 Mar 27]. Available from: https://www.gov.scot/publications/works-support-promote-shared-decisionmaking-synthesis-recent-evidence/pages/1/ 3. Ghesquiere AR, Patel SR, Kaplan DB, Bruce ML. Primary care providers’ bereavement care practices: Recommendations for research directions. Int J Geriatr Psychiatry. 2014 Dec;29(12):1221–9. 4. Nielsen MK, Christensen K, Neergaard MA, Bidstrup PE, Guldin M-B. Grief symptoms and primary care use: a prospective study of family caregivers. BJGP Open [Internet]. 2020 Aug 1 [cited 2021 Mar 27];4(3). Available from: https://bjgpopen.org/content/4/3/bjgpopen20X101063 5. O’Connor M, Breen LJ. General Practitioners’ experiences of bereavement care and their educational support needs: a qualitative study. BMC Medical Education. 2014 Mar 27;14(1):59. 6. Sikstrom L, Saikaly R, Ferguson G, Mosher PJ, Bonato S, Soklaridis S. Being there: A scoping review of grief support training in medical education. PLOS ONE. 2019 Nov 27;14(11):e0224325.
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4

McEntee, Alice, Sonia Hines, Joshua Trigg, et al. Tobacco cessation in CALD communities. The Sax Institute, 2022. http://dx.doi.org/10.57022/sneg4189.

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Background Australia is a multi-cultural society with increasing rates of people from culturally and linguistically diverse (CALD) backgrounds. On average, CALD groups have higher rates of tobacco use, lower participation in cancer screening programs, and poorer health outcomes than the general Australian population. Lower cancer screening and smoking cessation rates are due to differing cultural norms, health-related attitudes, and beliefs, and language barriers. Interventions can help address these potential barriers and increase tobacco cessation and cancer screening rates among CALD groups. Cancer Council NSW (CCNSW) aims to reduce the impact of cancer and improve cancer outcomes for priority populations including CALD communities. In line with this objective, CCNSW commissioned this rapid review of interventions implemented in Australia and comparable countries. Review questions This review aimed to address the following specific questions: Question 1 (Q1): What smoking cessation interventions have been proven effective in reducing or preventing smoking among culturally and linguistically diverse communities? Question 2 (Q2): What screening interventions have proven effective in increasing participation in population cancer screening programs among culturally and linguistically diverse populations? This review focused on Chinese-, Vietnamese- and Arabic-speaking people as they are the largest CALD groups in Australia and have high rates of tobacco use and poor screening adherence in NSW. Summary of methods An extensive search of peer-reviewed and grey literature published between January 2013-March 2022 identified 19 eligible studies for inclusion in the Q1 review and 49 studies for the Q2 review. The National Health and Medical Research Council (NHMRC) Levels of Evidence and Joanna Briggs Institute’s (JBI) Critical Appraisal Tools were used to assess the robustness and quality of the included studies, respectively. Key findings Findings are reported by components of an intervention overall and for each CALD group. By understanding the effectiveness of individual components, results will demonstrate key building blocks of an effective intervention. Question 1: What smoking cessation interventions have been proven effective in reducing or preventing smoking among culturally and linguistically diverse communities? Thirteen of the 19 studies were Level IV (L4) evidence, four were Level III (L3), one was Level II (L2), none were L1 (highest level of evidence) and one study’s evidence level was unable to be determined. The quality of included studies varied. Fifteen tobacco cessation intervention components were included, with most interventions involving at least three components (range 2-6). Written information (14 studies), and education sessions (10 studies) were the most common components included in an intervention. Eight of the 15 intervention components explored had promising evidence for use with Chinese-speaking participants (written information, education sessions, visual information, counselling, involving a family member or friend, nicotine replacement therapy, branded merchandise, and mobile messaging). Another two components (media campaign and telephone follow-up) had evidence aggregated across CALD groups (i.e., results for Chinese-speaking participants were combined with other CALD group(s)). No intervention component was deemed of sufficient evidence for use with Vietnamese-speaking participants and four intervention components had aggregated evidence (written information, education sessions, counselling, nicotine replacement therapy). Counselling was the only intervention component to have promising evidence for use with Arabic-speaking participants and one had mixed evidence (written information). Question 2: What screening interventions have proven effective in increasing participation in population cancer screening programs among culturally and linguistically diverse populations? Two of the 49 studies were Level I (L1) evidence, 13 L2, seven L3, 25 L4 and two studies’ level of evidence was unable to be determined. Eighteen intervention components were assessed with most interventions involving 3-4 components (range 1-6). Education sessions (32 studies), written information (23 studies) and patient navigation (10 studies) were the most common components. Seven of the 18 cancer screening intervention components had promising evidence to support their use with Vietnamese-speaking participants (education sessions, written information, patient navigation, visual information, peer/community health worker, counselling, and peer experience). The component, opportunity to be screened (e.g. mailed or handed a bowel screening test), had aggregated evidence regarding its use with Vietnamese-speaking participants. Seven intervention components (education session, written information, visual information, peer/community health worker, opportunity to be screened, counselling, and branded merchandise) also had promising evidence to support their use with Chinese-speaking participants whilst two components had mixed (patient navigation) or aggregated (media campaign) evidence. One intervention component for use with Arabic-speaking participants had promising evidence to support its use (opportunity to be screened) and eight intervention components had mixed or aggregated support (education sessions, written information, patient navigation, visual information, peer/community health worker, peer experience, media campaign, and anatomical models). Gaps in the evidence There were four noteworthy gaps in the evidence: 1. No systematic review was captured for Q1, and only two studies were randomised controlled trials. Much of the evidence is therefore based on lower level study designs, with risk of bias. 2. Many studies provided inadequate detail regarding their intervention design which impacts both the quality appraisal and how mixed finding results can be interpreted. 3. Several intervention components were found to have supportive evidence available only at the aggregate level. Further research is warranted to determine the interventions effectiveness with the individual CALD participant group only. 4. The evidence regarding the effectiveness of certain intervention components were either unknown (no studies) or insufficient (only one study) across CALD groups. This was the predominately the case for Arabic-speaking participants for both Q1 and Q2, and for Vietnamese-speaking participants for Q1. Further research is therefore warranted. Applicability Most of the intervention components included in this review are applicable for use in the Australian context, and NSW specifically. However, intervention components assessed as having insufficient, mixed, or no evidence require further research. Cancer screening and tobacco cessation interventions targeting Chinese-speaking participants were more common and therefore showed more evidence of effectiveness for the intervention components explored. There was support for cancer screening intervention components targeting Vietnamese-speaking participants but not for tobacco cessation interventions. There were few interventions implemented for Arabic-speaking participants that addressed tobacco cessation and screening adherence. Much of the evidence for Vietnamese and Arabic-speaking participants was further limited by studies co-recruiting multiple CALD groups and reporting aggregate results. Conclusion There is sound evidence for use of a range of intervention components to address tobacco cessation and cancer screening adherence among Chinese-speaking populations, and cancer screening adherence among Vietnamese-speaking populations. Evidence is lacking regarding the effectiveness of tobacco cessation interventions with Vietnamese- and Arabic-speaking participants, and cancer screening interventions for Arabic-speaking participants. More research is required to determine whether components considered effective for use in one CALD group are applicable to other CALD populations.
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