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Journal articles on the topic 'Far1'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Kemp, Hilary A., and George F. Sprague,. "Far3 and Five Interacting Proteins Prevent Premature Recovery from Pheromone Arrest in the Budding Yeast Saccharomyces cerevisiae." Molecular and Cellular Biology 23, no. 5 (2003): 1750–63. http://dx.doi.org/10.1128/mcb.23.5.1750-1763.2003.

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ABSTRACT In budding yeast, diffusible mating pheromones initiate a signaling pathway that culminates in several responses, including cell cycle arrest. Only a handful of genes required for the interface between pheromone response and the cell cycle have been identified, among them FAR1 and FAR3; of these, only FAR1 has been extensively characterized. In an effort to learn about the mechanism by which Far3 acts, we used the two-hybrid method to identify interacting proteins. We identified five previously uncharacterized open reading frames, dubbed FAR7, FAR8, FAR9, FAR10, and FAR11, that cause

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Alberghina, Lilia, Riccardo L. Rossi, Lorenzo Querin, Valeria Wanke, and Marco Vanoni. "A cell sizer network involving Cln3 and Far1 controls entrance into S phase in the mitotic cycle of budding yeast." Journal of Cell Biology 167, no. 3 (2004): 433–43. http://dx.doi.org/10.1083/jcb.200405102.

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Saccharomyces cerevisiae must reach a carbon source-modulated critical cell size, protein content per cell at the onset of DNA replication (Ps), in order to enter S phase. Cells grown in glucose are larger than cells grown in ethanol. Here, we show that an increased level of the cyclin-dependent inhibitor Far1 increases cell size, whereas far1Δ cells start bud emergence and DNA replication at a smaller size than wild type. Cln3Δ, far1Δ, and strains overexpressing Far1 do not delay budding during an ethanol glucose shift-up as wild type does. Together, these findings indicate that Cln3 has to o

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3

McKinney, J. D., and F. R. Cross. "FAR1 and the G1 phase specificity of cell cycle arrest by mating factor in Saccharomyces cerevisiae." Molecular and Cellular Biology 15, no. 5 (1995): 2509–16. http://dx.doi.org/10.1128/mcb.15.5.2509.

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Significant accumulation of Far1p is restricted to the G1 phase of the Saccharomyces cerevisiae cell cycle. Here we demonstrate yeast cell cycle regulation of Far1p proteolysis. Deletions within the 50 N-terminal amino acids of Far1p increase stability and reduce cell cycle regulation of Far1p abundance. Whereas wild-type Far1p specifically and exclusively promotes G1 phase arrest in response to mating factor, stabilized Far1p promoted arrest both during and after G1. The loss of the G1 specificity of Far1p action requires elimination of FAR1 transcriptional regulation (by means of the GAL1 pr

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Pracheil, Tammy, and Zhengchang Liu. "Tiered Assembly of the Yeast Far3-7-8-9-10-11 Complex at the Endoplasmic Reticulum." Journal of Biological Chemistry 288, no. 23 (2013): 16986–97. http://dx.doi.org/10.1074/jbc.m113.451674.

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Target of rapamycin signaling is a conserved, essential pathway integrating nutritional cues with cell growth and proliferation. The target of rapamycin kinase exists in two distinct complexes, TORC1 and TORC2. It has been reported that protein phosphatase 2A (PP2A) and the Far3-7-8-9-10-11 complex (Far complex) negatively regulate TORC2 signaling in yeast. The Far complex, originally identified as factors required for pheromone-induced cell cycle arrest, and PP2A form the yeast counterpart of the STRIPAK complex, which was first isolated in mammals. The cellular localization of the Far comple

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Wang, Jinwu, Xingyu Wang, Linzhen Xie, Wenhao Zheng, Hua Chen, and Leyi Cai. "Comparison of radiographs and CT features between posterior Pilon fracture and posterior malleolus fracture: a retrospective cohort study." British Journal of Radiology 93, no. 1110 (2020): 20191030. http://dx.doi.org/10.1259/bjr.20191030.

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Objectives: This study explored the morphological differences between posterior Pilon fracture and posterior malleolus fracture from radiographs and CT to provide detail for diagnosis and treatment of them. Methods: Radiographs and CT imaging data of 174 patients with distal posterior tibial fractures who were treated from January 2013 to January 2019 were retrospectively analyzed. Based on the operation and imaging examination, the fractures were classified into posterior Pilon fractures and posterior malleolus fractures. Radiographic parameters including the width, height, depth, α angle, β

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Liu, Zhengjun, Chuanjing An, Yiqing Zhao, et al. "Genome-Wide Identification and Characterization of the CsFHY3/FAR1 Gene Family and Expression Analysis under Biotic and Abiotic Stresses in Tea Plants (Camellia sinensis)." Plants 10, no. 3 (2021): 570. http://dx.doi.org/10.3390/plants10030570.

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The FHY3/FAR1 transcription factor family, derived from transposases, plays important roles in light signal transduction, and in the growth and development of plants. However, the homologous genes in tea plants have not been studied. In this study, 25 CsFHY3/FAR1 genes were identified in the tea plant genome through a genome-wide study, and were classified into five subgroups based on their phylogenic relationships. Their potential regulatory roles in light signal transduction and photomorphogenesis, plant growth and development, and hormone responses were verified by the existence of the corr

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Gartner, Anton, Alexandra Jovanović, Doo-Il Jeoung, Sarah Bourlat, Frederick R. Cross, and Gustav Ammerer. "Pheromone-Dependent G1 Cell Cycle Arrest Requires Far1 Phosphorylation, but May Not Involve Inhibition of Cdc28-Cln2 Kinase, In Vivo." Molecular and Cellular Biology 18, no. 7 (1998): 3681–91. http://dx.doi.org/10.1128/mcb.18.7.3681.

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ABSTRACT In yeast, the pheromone α-factor acts as an antiproliferative factor that induces G1 arrest and cellular differentiation. Previous data have indicated that Far1, a factor dedicated to pheromone-induced cell cycle arrest, is under positive and negative posttranslational regulation. Phosphorylation by the pheromone-stimulated mitogen-activated protein (MAP) kinase Fus3 has been thought to enhance the binding of Far1 to G1-specific cyclin-dependent kinase (Cdk) complexes, thereby inhibiting their catalytic activity. Cdk-dependent phosphorylation events were invoked to account for the hig

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8

Yilmaz, Ahmet Aşkın, Serdar Coşkun, Sümer Aras, and İlker Büyük. "Integrative multi-omics analysis of the FAR1 gene family in Phaseolus vulgaris." Communications Faculty of Science University of Ankara Series C Biology Geological Engineering and Geophysical Engineering 34, no. 2 (2025): 154–75. https://doi.org/10.53447/communc.1657858.

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An essential function of the Far-red impaired response 1 (FAR1) gene family is to regulate the growth and developmental phases of plants. The FAR1 gene family has not yet been examined in Phaseolus vulgaris (common bean), despite the fact that it has been examined in several plant species utilizing bioinformatics technologies. This research was the first that the FAR1 gene family was identified and characterized throughout the whole genome of P. vulgaris. An in-silico approach was employed, utilizing various bioinformatics tools to explore the molecular and physicochemical characteristics of F

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9

Li, Xuelian, Yihua Li, Yali Qiao, et al. "Genome-Wide Identification and Expression Analysis of FAR1/FHY3 Gene Family in Cucumber (Cucumis sativus L.)." Agronomy 14, no. 1 (2023): 50. http://dx.doi.org/10.3390/agronomy14010050.

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The FAR1-RELATED SEQUENCE1 (FAR1) and FAR-RED ELONGATED HYPOCOTYL3 (FHY3) gene family plays a crucial role in various physiological and developmental processes, including seed germination, photomorphogenesis, flowering and stress responses. However, genome analysis of FAR1/FHY3 in cucumber (Cucumis sativus L.) has not been systemically investigated. In this study, 20 FAR1/FHY3 genes in cucumber were identified. The 20 FAR1/FHY3 members are randomly distributed on six chromosomes. The examination of subcellular localization indicated that the nucleus is the primary site where the 20 FAR1/FHY3 m

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10

Chang, F., and I. Herskowitz. "Phosphorylation of FAR1 in response to alpha-factor: a possible requirement for cell-cycle arrest." Molecular Biology of the Cell 3, no. 4 (1992): 445–50. http://dx.doi.org/10.1091/mbc.3.4.445.

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Exposure of yeast a cells to alpha-factor causes cells to arrest in the G1 phase of the cell cycle. The FAR1 gene is required for this cell-cycle arrest; its product is necessary for the inhibition of a G1 cyclin, CLN2. Earlier work demonstrated that alpha-factor caused an increase in the transcription of FAR1 severalfold over a measurable basal level. We now show that transcriptional induction of FAR1 from a heterologous promoter is not sufficient to inhibit CLN2 in the absence of alpha-factor. We also show that FAR1 is phosphorylated in response to alpha-factor and propose that this phosphor

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Oehlen, L. J., J. D. McKinney, and F. R. Cross. "Ste12 and Mcm1 regulate cell cycle-dependent transcription of FAR1." Molecular and Cellular Biology 16, no. 6 (1996): 2830–37. http://dx.doi.org/10.1128/mcb.16.6.2830.

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The transcripts of many genes involved in Saccharomyces cerevisiae mating were found to fluctuate during the cell cycle. In the absence of a functional Ste12 transcription factor, both the levels and the cell cycle pattern of expression of these genes were affected. FUS1 and AGA1 levels, which are maximally expressed only in G1-phase cells, were strongly reduced in ste12- cells. The cell cycle transcription pattern for FAR1 was changed in ste12- cells: the gene was still significantly expressed in G2/M, but transcript levels were strongly reduced in G1 phase, resulting in a lack of Far1 protei

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Valdivieso, M. H., K. Sugimoto, K. Y. Jahng, P. M. Fernandes, and C. Wittenberg. "FAR1 is required for posttranscriptional regulation of CLN2 gene expression in response to mating pheromone." Molecular and Cellular Biology 13, no. 2 (1993): 1013–22. http://dx.doi.org/10.1128/mcb.13.2.1013-1022.1993.

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Yeast cells arrest during the G1 interval of the cell cycle in response to peptide mating pheromones. The FAR1 gene is required for cell cycle arrest but not for a number of other aspects of the pheromone response. Genetic evidence suggests that FAR1 is required specifically for inactivation of the G1 cyclin CLN2. From these observations, the FAR1 gene has been proposed to encode an element of the interface between the mating pheromone signal transduction pathway and the cell cycle regulatory apparatus. We show here that FAR1 is necessary for the decrease in CLN1 and CLN2 transcript accumulati

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Valdivieso, M. H., K. Sugimoto, K. Y. Jahng, P. M. Fernandes, and C. Wittenberg. "FAR1 is required for posttranscriptional regulation of CLN2 gene expression in response to mating pheromone." Molecular and Cellular Biology 13, no. 2 (1993): 1013–22. http://dx.doi.org/10.1128/mcb.13.2.1013.

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Yeast cells arrest during the G1 interval of the cell cycle in response to peptide mating pheromones. The FAR1 gene is required for cell cycle arrest but not for a number of other aspects of the pheromone response. Genetic evidence suggests that FAR1 is required specifically for inactivation of the G1 cyclin CLN2. From these observations, the FAR1 gene has been proposed to encode an element of the interface between the mating pheromone signal transduction pathway and the cell cycle regulatory apparatus. We show here that FAR1 is necessary for the decrease in CLN1 and CLN2 transcript accumulati

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Cui, Weiwei, Dong Liu, Wei Gu, and Bo Chu. "Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis." Cell Death & Differentiation 28, no. 8 (2021): 2536–51. http://dx.doi.org/10.1038/s41418-021-00769-0.

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AbstractIt is well established that ferroptosis is primarily induced by peroxidation of long-chain poly-unsaturated fatty acid (PUFA) through nonenzymatic oxidation by free radicals or enzymatic stimulation of lipoxygenase. Although there is emerging evidence that long-chain saturated fatty acid (SFA) might be implicated in ferroptosis, it remains unclear whether and how SFA participates in the process of ferroptosis. Using endogenous metabolites and genome-wide CRISPR screening, we have identified FAR1 as a critical factor for SFA-mediated ferroptosis. FAR1 catalyzes the reduction of C16 or C

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15

Qaseem, Qalb E. Abbas, and Muhammad Amir. "Genome-wide Characterization of Far-Red Impaired Response 1 (FAR1) Transcription Factor Gene Family in Wild Rice Oryza brachyantha." Integrative Plant Biotechnology 2, no. 1 (2024): 27–36. https://doi.org/10.55627/pbiotech.002.01.0957.

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The wild rice variety, Oryza brachyantha, is categorized as having the F genome type and is a member of the primitive Oryza lineage. The O. brachyantha is particularly noteworthy because of its genetic variability and applications in rice breeding, especially for increasing traits like disease resistance and tolerance to abiotic stimuli. Bisexual spikelets, two almost completely developed sterile lemmas, acuminate entire lemmas that are occasionally setiform, herbaceous to crustaceous leaves, and herbaceous margins are the characteristics of Oryza species. The FAR1 gene family is a crucial par

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Pope, Patricia A., and Peter M. Pryciak. "Functional overlap among distinct G1/S inhibitory pathways allows robust G1 arrest by yeast mating pheromones." Molecular Biology of the Cell 24, no. 23 (2013): 3675–88. http://dx.doi.org/10.1091/mbc.e13-07-0373.

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In budding yeast, mating pheromones arrest the cell cycle in G1 phase via a pheromone-activated Cdk-inhibitor (CKI) protein, Far1. Alternate pathways must also exist, however, because deleting the cyclin CLN2 restores pheromone arrest to far1∆ cells. Here we probe whether these alternate pathways require the G1/S transcriptional repressors Whi5 and Stb1 or the CKI protein Sic1, whose metazoan analogues (Rb or p27) antagonize cell cycle entry. Removing Whi5 and Stb1 allows partial escape from G1 arrest in far1∆ cln2∆ cells, along with partial derepression of G1/S genes, which implies a represso

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Marsh, Kayleigh G., Adrian Arrieta, Donna J. Thuerauf, Erik A. Blackwood, Lauren MacDonnell, and Christopher C. Glembotski. "The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes." American Journal of Physiology-Heart and Circulatory Physiology 320, no. 5 (2021): H1813—H1821. http://dx.doi.org/10.1152/ajpheart.00999.2020.

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Zhao, Dongbo, Peiyan Guan, Longxue Wei, et al. "Comprehensive identification and expression analysis of FAR1/FHY3 genes under drought stress in maize (Zea mays L.)." PeerJ 12 (June 28, 2024): e17684. http://dx.doi.org/10.7717/peerj.17684.

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Background FAR1/FHY3 transcription factors are derived from transposase, which play important roles in light signal transduction, growth and development, and response to stress by regulating downstream gene expression. Although many FAR1/FHY3 members have been identified in various species, the FAR1/FHY3 genes in maize are not well characterized and their function in drought are unknown. Method The FAR1/FHY3 family in the maize genome was identified using PlantTFDB, Pfam, Smart, and NCBI-CDD websites. In order to investigate the evolution and functions of FAR1 genes in maize, the information o

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Valtz, N., M. Peter, and I. Herskowitz. "FAR1 is required for oriented polarization of yeast cells in response to mating pheromones." Journal of Cell Biology 131, no. 4 (1995): 863–73. http://dx.doi.org/10.1083/jcb.131.4.863.

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Cell polarization involves specifying an area on the cell surface and organizing the cytoskeleton towards that landmark. The mechanisms by which external signals are translated into internal landmarks for polarization are poorly understood. The yeast Saccharomyces cerevisiae exhibits polarized growth during mating: the actin cytoskeleton of each cell polarizes towards its partner, presumably to allow efficient cell fusion. The external signal which determines the landmark for polarization is thought to be a gradient of peptide pheromone released by the mating partner. Here we described mutants

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Zhang, Donghong, and Paul A. Lefebvre. "FAR1, a Negative Regulatory Locus Required for the Repression of the Nitrate Reductase Gene in Chlamydomonas reinhardtii." Genetics 146, no. 1 (1997): 121–33. http://dx.doi.org/10.1093/genetics/146.1.121.

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In Chlamydomonas reinhardtii, the genes required for nitrate assimilation, including the gene encoding nitrate reductase (NIT1), are subject to repression by ammonia. To study the mechanism of ammonia repression, we employed two approaches to search for mutants with defective repression of NIT1 gene expression. (1) PF14, a gene required for flagellar function, was used as a reporter gene for expression from the NIT1 promoter. When introduced into a pf14 mutant host, the NZTl:PF14 chimeric construct produced a transformant (T10-10B) with a conditional swimming phenotype. Spontaneous mutants wit

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Elion, E. A., B. Satterberg, and J. E. Kranz. "FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1." Molecular Biology of the Cell 4, no. 5 (1993): 495–510. http://dx.doi.org/10.1091/mbc.4.5.495.

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The mitogen-activated protein (MAP) kinase homologue FUS3 mediates both transcription and G1 arrest in a pheromone-induced signal transduction cascade in Saccharomyces cerevisiae. We report an in vitro kinase assay for FUS3 and its use in identifying candidate substrates. The assay requires catalytically active FUS3 and pheromone induction. STE7, a MAP kinase kinase homologue, is needed for maximal activity. At least seven proteins that specifically associate with FUS3 are phosphorylated in the assay. Many of these substrates are physiologically relevant and are affected by in vivo levels of n

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Nern, Aljoscha, та Robert A. Arkowitz. "A Cdc24p-Far1p-Gβγ Protein Complex Required for Yeast Orientation during Mating". Journal of Cell Biology 144, № 6 (1999): 1187–202. http://dx.doi.org/10.1083/jcb.144.6.1187.

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Oriented cell growth requires the specification of a site for polarized growth and subsequent orientation of the cytoskeleton towards this site. During mating, haploid Saccharomyces cerevisiae cells orient their growth in response to a pheromone gradient overriding an internal landmark for polarized growth, the bud site. This response requires Cdc24p, Far1p, and a heterotrimeric G-protein. Here we show that a two- hybrid interaction between Cdc24p and Gβ requires Far1p but not pheromone-dependent MAP-kinase signaling, indicating Far1p has a role in regulating the association of Cdc24p and Gβ.

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Jeoung, Doo-Il, L. J. W. M. Oehlen, and Frederick R. Cross. "Cln3-Associated Kinase Activity inSaccharomyces cerevisiae Is Regulated by the Mating Factor Pathway." Molecular and Cellular Biology 18, no. 1 (1998): 433–41. http://dx.doi.org/10.1128/mcb.18.1.433.

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ABSTRACT The Saccharomyces cerevisiae cell cycle is arrested in G1 phase by the mating factor pathway. Genetic evidence has suggested that the G1 cyclins Cln1, Cln2, and Cln3 are targets of this pathway whose inhibition results in G1 arrest. Inhibition of Cln1- and Cln2-associated kinase activity by the mating factor pathway acting through Far1 has been described. Here we report that Cln3-associated kinase activity is inhibited by mating factor treatment, with dose response and timing consistent with involvement in cell cycle arrest. No regulation of Cln3-associated kinase was observed in a fu

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Horecka, Joe, and George F. Sprague. "Identification and Characterization of FAR3, a Gene Required for Pheromone-Mediated G1 Arrest in Saccharomyces cerevisiae." Genetics 144, no. 3 (1996): 905–21. http://dx.doi.org/10.1093/genetics/144.3.905.

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Abstract In haploid Saccharomyces cerevisiae cells, mating pheromones activate a signal transduction pathway that leads to cell cycle arrest in the G1 phase and to transcription induction of genes that promote conjugation. To identify genes that link the signal transduction pathway and the cell cycle machinery, we developed a selection strategy to isolate yeast mutants specifically defective for G1 arrest. Several of these mutants identified previously known genes, including CLN3, FUS3, and FAR1. In addition, a new gene, FAR3, was identified and characterized. FAR3 encodes a novel protein of 2

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Young Chae, Geun, Woo-Jong Hong, Min Jeong Jang, Ki-Hong Jung, and Seungill Kim. "Recurrent mutations promote widespread structural and functional divergence of MULE-derived genes in plants." Nucleic Acids Research 49, no. 20 (2021): 11765–77. http://dx.doi.org/10.1093/nar/gkab932.

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Abstract Transposable element (TE)-derived genes are increasingly recognized as major sources conferring essential traits in agriculturally important crops but underlying evolutionary mechanisms remain obscure. We updated previous annotations and constructed 18,744 FAR-RED IMPAIRED RESPONSE1 (FAR1) genes, a transcription factor family derived from Mutator-like elements (MULEs), from 80 plant species, including 15,546 genes omitted in previous annotations. In-depth sequence comparison of the updated gene repertoire revealed that FAR1 genes underwent continuous structural divergence via frameshi

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Honsho, Masanori, Fabian Dorninger, Yuichi Abe, et al. "Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum." Journal of Biochemistry 166, no. 4 (2019): 353–61. http://dx.doi.org/10.1093/jb/mvz043.

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Abstract Synthesis of ethanolamine plasmalogen (PlsEtn) is regulated by modulating the stability of fatty acyl-CoA reductase 1 (Far1) on peroxisomal membrane, a rate-limiting enzyme in plasmalogen synthesis. Dysregulation of plasmalogen homeostasis impairs cholesterol biosynthesis in cultured cells by altering the stability of squalene epoxidase (SQLE). However, regulation of PlsEtn synthesis and physiological consequences of plasmalogen homeostasis in tissues remain unknown. In the present study, we found that the protein but not the transcription level of Far1 in the cerebellum of the Pex14

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Dorer, R., P. M. Pryciak, and L. H. Hartwell. "Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients." Journal of Cell Biology 131, no. 4 (1995): 845–61. http://dx.doi.org/10.1083/jcb.131.4.845.

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During conjugation, haploid S. cerevisiae cells find one another by polarizing their growth toward each other along gradients of pheromone (chemotropism). We demonstrate that yeast cells exhibit a second mating behavior: when their receptors are saturated with pheromone, wild-type a cells execute a default pathway and select a mate at random. These matings are less efficient than chemotropic matings, are induced by the same dose of pheromone that induces shmoo formation, and appear to use a site near the incipient bud site for polarization. We show that the SPA2 gene is specifically required f

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Tyers, M., and B. Futcher. "Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes." Molecular and Cellular Biology 13, no. 9 (1993): 5659–69. http://dx.doi.org/10.1128/mcb.13.9.5659-5669.1993.

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In the yeast Saccharomyces cerevisiae, the Cdc28 protein kinase controls commitment to cell division at Start, but no biologically relevant G1-phase substrates have been identified. We have studied the kinase complexes formed between Cdc28 and each of the G1 cyclins Cln1, Cln2, and Cln3. Each complex has a specific array of coprecipitated in vitro substrates. We identify one of these as Far1, a protein required for pheromone-induced arrest at Start. Treatment with alpha-factor induces a preferential association and/or phosphorylation of Far1 by the Cln1, Cln2, and Cln3 kinase complexes. This i

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Tyers, M., and B. Futcher. "Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes." Molecular and Cellular Biology 13, no. 9 (1993): 5659–69. http://dx.doi.org/10.1128/mcb.13.9.5659.

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In the yeast Saccharomyces cerevisiae, the Cdc28 protein kinase controls commitment to cell division at Start, but no biologically relevant G1-phase substrates have been identified. We have studied the kinase complexes formed between Cdc28 and each of the G1 cyclins Cln1, Cln2, and Cln3. Each complex has a specific array of coprecipitated in vitro substrates. We identify one of these as Far1, a protein required for pheromone-induced arrest at Start. Treatment with alpha-factor induces a preferential association and/or phosphorylation of Far1 by the Cln1, Cln2, and Cln3 kinase complexes. This i

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de Silva, Nayana D. G., Jhadeswar Murmu, Denise Chabot, et al. "Root Suberin Plays Important Roles in Reducing Water Loss and Sodium Uptake in Arabidopsis thaliana." Metabolites 11, no. 11 (2021): 735. http://dx.doi.org/10.3390/metabo11110735.

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Suberin is a cell-wall-associated hetero-polymer deposited in specific plant tissues. The precise role of its composition and lamellae structure in protecting plants against abiotic stresses is unclear. In Arabidopsis thaliana, we tested the biochemical and physiological responses to water deficiency and NaCl treatment in mutants that are differentially affected in suberin composition and lamellae structure. Chronic drought stress increased suberin and suberin-associated waxes in wild-type plants. Suberin-deficient mutants were not more susceptible than the wild-type to the chronic drought str

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van Drogen, Frank, Ranjan Mishra, Fabian Rudolf, et al. "Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5." Journal of Cell Biology 218, no. 9 (2019): 3117–33. http://dx.doi.org/10.1083/jcb.201808161.

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Cells continuously adapt cellular processes by integrating external and internal signals. In yeast, multiple stress signals regulate pheromone signaling to prevent mating under unfavorable conditions. However, the underlying crosstalk mechanisms remain poorly understood. Here, we show that mechanical stress activates Pkc1, which prevents lysis of pheromone-treated cells by inhibiting polarized growth. In vitro Pkc1 phosphorylates conserved residues within the RING-H2 domains of the scaffold proteins Far1 and Ste5, which are also phosphorylated in vivo. Interestingly, Pkc1 triggers dispersal of

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Domergue, Frédéric, Sollapura J. Vishwanath, Jérôme Joubès, et al. "Three Arabidopsis Fatty Acyl-Coenzyme A Reductases, FAR1, FAR4, and FAR5, Generate Primary Fatty Alcohols Associated with Suberin Deposition." Plant Physiology 153, no. 4 (2010): 1539–54. http://dx.doi.org/10.1104/pp.110.158238.

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Cherkasova, Vera, David M. Lyons, and Elaine A. Elion. "Fus3p and Kss1p Control G1 Arrest in Saccharomyces cerevisiae Through a Balance of Distinct Arrest and Proliferative Functions That Operate in Parallel With Far1p." Genetics 151, no. 3 (1999): 989–1004. http://dx.doi.org/10.1093/genetics/151.3.989.

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AbstractIn Saccharomyces cerevisiae, mating pheromones activate two MAP kinases (MAPKs), Fus3p and Kss1p, to induce G1 arrest prior to mating. Fus3p is known to promote G1 arrest by activating Far1p, which inhibits three Clnp/Cdc28p kinases. To analyze the contribution of Fus3p and Kss1p to G1 arrest that is independent of Far1p, we constructed far1 CLN strains that undergo G1 arrest from increased activation of the mating MAP kinase pathway. We find that Fus3p and Kss1p both control G1 arrest through multiple functions that operate in parallel with Far1p. Fus3p and Kss1p together promote G1 a

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Atir-Lande, Avigail, Tsvia Gildor, and Daniel Kornitzer. "Role for the SCFCDC4Ubiquitin Ligase inCandida albicansMorphogenesis." Molecular Biology of the Cell 16, no. 6 (2005): 2772–85. http://dx.doi.org/10.1091/mbc.e05-01-0079.

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The ability of Candida albicans, a major fungal pathogen, to switch between a yeast form, and a hyphal (mold) form is recognized as being important for the ability of the organism to invade the host and cause disease. We found that a C. albicans mutant deleted for CaCDC4, a homologue of the Saccharomyces cerevisiae F-box protein component of the SCFCDC4ubiquitin ligase, is viable and displays constitutive filamentous, mostly hyphal, growth. The phenotype of the Cacdc4–/– mutant suggests that ubiquitin-mediated protein degradation is involved in the regulation of the dimorphic switch of C. albi

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Chelimsky, E., D. Cordray, and L. e. Datta. "Federal Evaluation: the Pendulum Has Swung Too Far1." American Journal of Evaluation 10, no. 2 (1989): 25–29. http://dx.doi.org/10.1177/109821408901000204.

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Chelimsky, Eleanor, David Cordray, and Lois-ellin Datta. "Federal evaluation: The pendulum has swung too far1." Evaluation Practice 10, no. 2 (1989): 25–30. http://dx.doi.org/10.1016/s0886-1633(89)80050-9.

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Mou, Sharah Jabeen, and Prodipto Bishnu Angon. "Genome-wide characterization and expression profiling of FARL (FHY3/FAR1) family genes in Zea mays." Journal of Genetic Engineering and Biotechnology 22, no. 3 (2024): 100401. http://dx.doi.org/10.1016/j.jgeb.2024.100401.

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Han, Yuekun, Hefen Cheng, Yaolan Jiang, et al. "Identification and Characterization of the BnFAR1/FHY3 Gene Family and Expression Analysis under Shading and Low-Temperature Responses in Brassica napus L." Agronomy 14, no. 1 (2024): 202. http://dx.doi.org/10.3390/agronomy14010202.

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FHY3 and FAR1 serve as positive regulators of the phyA-mediated far-red light signal pathway, influencing plant growth and development by regulating the expression of downstream genes. However, little is known about the FAR1/FHY3 family in Brassica species. A total of 21 members of the BnFAR1/FHY3 gene family were identified in the Brassica napus genome, exhibiting an uneven distribution across ten B. napus chromosomes. A phylogenetic analysis showed that the BnFAR1/FHY3 family could be divided into four subfamilies. Putative cis-elements in the BnFAR1/FHY3 promoter regions were also identifie

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Esch, R. Keith, Yuqi Wang, and Beverly Errede. "Pheromone-Induced Degradation of Ste12 Contributes to Signal Attenuation and the Specificity of Developmental Fate." Eukaryotic Cell 5, no. 12 (2006): 2147–60. http://dx.doi.org/10.1128/ec.00270-06.

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ABSTRACT The Ste12 transcription factor of Saccharomyces cerevisiae regulates transcription programs controlling two different developmental fates. One is differentiation into a mating-competent form that occurs in response to mating pheromone. The other is the transition to a filamentous-growth form that occurs in response to nutrient deprivation. These two distinct roles for Ste12 make it a focus for studies into regulatory mechanisms that impart biological specificity. The transient signal characteristic of mating differentiation led us to test the hypothesis that regulation of Ste12 turnov

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Udo, Edet E., and Eiman Sarkhoo. "Genetic analysis of high-level mupirocin resistance in the ST80 clone of community-associated meticillin-resistant Staphylococcus aureus." Journal of Medical Microbiology 59, no. 2 (2010): 193–99. http://dx.doi.org/10.1099/jmm.0.013268-0.

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Four community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) isolates expressing high-level mupirocin resistance (MIC >1024 mg l−1) were isolated from four sites of a diabetic patient and characterized for the genetic location of their resistance determinants and typed using PFGE, staphylococcal cassette chromosome mec (SCCmec), the coagulase gene and multilocus sequence typing to ascertain their relatedness. The presence of genes for resistance to high-level mupirocin (mupA), tetracycline (tetK) and fusidic acid (far1), Panton–Valentine leukocidin (PVL), accessory gene re

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Busti, Stefano, Laura Gotti, Chiara Balestrieri, et al. "Overexpression of Far1, a cyclin-dependent kinase inhibitor, induces a large transcriptional reprogramming in which RNA synthesis senses Far1 in a Sfp1-mediated way." Biotechnology Advances 30, no. 1 (2012): 185–201. http://dx.doi.org/10.1016/j.biotechadv.2011.09.007.

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Tang, Huaijun, De Jing, Cheng Liu, et al. "Genome-Wide Identification and Expression Analyses of the FAR1/FHY3 Gene Family Provide Insight into Inflorescence Development in Maize." Current Issues in Molecular Biology 46, no. 1 (2024): 430–49. http://dx.doi.org/10.3390/cimb46010027.

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As transcription factors derived from transposase, FAR-RED IMPAIRED RESPONSE1 (FAR1) and its homolog FHY3 play crucial roles in the regulation of light signaling and various stress responses by coordinating the expression of downstream target genes. Despite the extensive investigation of the FAR1/FHY3 family in Arabidopsis thaliana and other species, a comprehensive examination of these genes in maize has not been conducted thus far. In this study, we employed a genomic mining approach to identify 16 ZmFAR1 genes in the maize inbred line B73, which were further classified into five subgroups b

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Wang, Hai, and Haiyang Wang. "Multifaceted roles of FHY3 and FAR1 in light signaling and beyond." Trends in Plant Science 20, no. 7 (2015): 453–61. http://dx.doi.org/10.1016/j.tplants.2015.04.003.

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bin Yusof, Mohammad Termizi, Michael J. Kershaw, Darren M. Soanes, and Nicholas J. Talbot. "FAR1 and FAR2 Regulate the Expression of Genes Associated with Lipid Metabolism in the Rice Blast Fungus Magnaporthe oryzae." PLoS ONE 9, no. 6 (2014): e99760. http://dx.doi.org/10.1371/journal.pone.0099760.

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Honsho, Masanori, and Yukio Fujiki. "Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review." Membranes 13, no. 9 (2023): 764. http://dx.doi.org/10.3390/membranes13090764.

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Plasmalogens are a unique family of cellular glycerophospholipids that contain a vinyl-ether bond. The synthesis of plasmalogens is initiated in peroxisomes and completed in the endoplasmic reticulum. Plasmalogens are transported to the post-Golgi compartment, including endosomes and plasma membranes, in a manner dependent on ATP, but not vesicular transport. Plasmalogens are preferentially localized in the inner leaflet of the plasma membrane in a manner dependent on P4-type ATPase ATP8B2, that associates with the CDC50 subunit. Plasmalogen biosynthesis is spatiotemporally regulated by a feed

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Peter, M., and I. Herskowitz. "Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1." Science 265, no. 5176 (1994): 1228–31. http://dx.doi.org/10.1126/science.8066461.

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McKinney, J. D., F. Chang, N. Heintz, and F. R. Cross. "Negative regulation of FAR1 at the Start of the yeast cell cycle." Genes & Development 7, no. 5 (1993): 833–43. http://dx.doi.org/10.1101/gad.7.5.833.

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Devlin, Paul F., and Hamad Siddiqui. "FHY3 and FAR1 mediate red light input to the Arabidopsis circadian clock." Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 153, no. 2 (2009): S207. http://dx.doi.org/10.1016/j.cbpa.2009.04.475.

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Hudson, M., C. Ringli, M. T. Boylan, and P. H. Quail. "The FAR1 locus encodes a novel nuclear protein specific to phytochrome A signaling." Genes & Development 13, no. 15 (1999): 2017–27. http://dx.doi.org/10.1101/gad.13.15.2017.

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Peter, Matthias, Anton Gartner, Joe Horecka, Gustav Ammerer, and Ira Herskowitz. "FAR1 links the signal transduction pathway to the cell cycle machinery in yeast." Cell 73, no. 4 (1993): 747–60. http://dx.doi.org/10.1016/0092-8674(93)90254-n.

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