Contents
Academic literature on the topic 'Fast Disintegrating Tablets Super-Disintegrants Mouth Disintegrating Tablets'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Fast Disintegrating Tablets Super-Disintegrants Mouth Disintegrating Tablets.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Fast Disintegrating Tablets Super-Disintegrants Mouth Disintegrating Tablets"
1
M, Nandhini, Vijaya Kumar Voleti, Ramesh Yamuna, et al. "Applications of the Natural Polymers for Fast Dissolving Tablets." International Journal of Clinical Pharmacokinetics and Medical Sciences 4, no. 1 (2024): 34–40. http://dx.doi.org/10.26452/ijcpms.v4i1.584.
Full textAbstract:
Oral route is the safest, most convenient, and economical route for administration of different drugs. Oral disintegrating tablets becoming very popular in the current scenario, as they facilely disintegrated in mouth within fewseconds of the time after its administration withoutthe need of water. Conventional dosage form has a limitations like dysphagia (arduousness in swallowing), in pediatric and geriatric patients, which have been overcome by oral disintegrating tablets. To prepare the same super disintegrating agents plays vital role. Natural Super disintegrants gained an advantage over the synthetic super disintegrants since they are chemicallyinert, non-toxic, less expensive, easily available, biodegradable in nature. Natural polymers such as locust bean gum, banana powder, pectin from mango peels, as well as the mucilageofHibiscus rosa-sinenses improve tablet qualities and are used as superdisintegrants, binder, and diluents to speed up the disintegration process as well as improve the solubilityofpoorlysoluble drugs. Natural super disintegrants are obtained from various sources of natural origin, as well as being affordable, nontoxic, biodegradable, environmentally benign, free of negative effects, as well as renewable. From the different extensive literature review, It is observed that based on research showing that natural polymersare more effectiveandsafe than synthetic ones. Thegoal ofthe current reviewpaper is to examine the natural polymersthat have FDAapproval and are used in fast dissolving tablets.
2
C., Haranath* T. Srikanth M. Suresh Krishna G. Chaithanya Barghav C. Mahesh Reddy. "FORMULATION AND INVITRO EVALUATION OF FAST DISINTEGRATING TABLETS OF AN ANTI-INFLAMMATORY DRUG." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 10790–99. https://doi.org/10.5281/zenodo.3229226.
Full textAbstract:
<em>Oral disintegrating tablets are defined as the tablets that disperse or disintegrates in less than one minute in the mouth prior to being swallowed, which results in the rapid dissolution and absorption of the active pharmaceutical ingredient contained in the tablet, providing rapid onset of action. Aceclofenac is a poorly water-soluble drug. The solubility of the drug was enhanced by solid dispersion technique using mannitol as the carrier. In the present study, 9 formulations were developed by using different super disintegrants like cross povidone, sodium starchglycolate and cross carmellose sodium in various ratios. The tablets were prepared by direct compression method and evaluated for precompression parameters like bulk density tapped density,angle of repose, compressibilityindex, Hausner's ratio, and post-compression parameters like hardness, friability,drugcontent, disintegration, and dissolution. The results were found to be satisfactory.Tablets which were prepared by cross povidone 5%(F9 formulation) showed the best results.The percentage of drug release was found to be 98.23% at 30 minutes and disintegration time was found to be 17 seconds.</em> <strong><em>Keywords: </em></strong><em>Oral disintegrating tablets,aceclofenac,solid dispersions ,super disintegrants.</em>
3
Sneha, Ms Shinde. "Review Article A Detailed Study on Disintegrating Agents and an Overview on Oral Disintegration Tablet." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 04 (2024): 1–5. http://dx.doi.org/10.55041/ijsrem30535.
Full textAbstract:
Nowadays, the administration of drugs through the oral route is becoming less common, accounting for only about 75% of all drug administrations compared to other routes. A new type of dosage form called oral disintegrating tablets has gained popularity in recent decades due to their rapid disintegration and dissolution. These tablets disintegrate in the mouth within seconds (25-40 seconds) without the need for water, as the oral mucosa alone is sufficient for the tablet to dissolve. The selection of a suitable disintegrating agent is crucial to achieve optimal bioavailability. A preparation may contain one or multiple disintegrating agents to ensure maximum disintegration and bioavailability. These tablets are also known as Oro disintegration tablets. Disintegrating agents are rarely used in solid unit dosage forms, typically comprising only 1-10% of the total dosage unit. The use of super disintegrates in these tablets enhances the drug's efficacy by promoting rapid dissolution. Various disintegrating agents, super disintegrates, and excipients are employed in the formulation of oral disintegrating tablets. This review article provides an overview of different types of disintegrates, including natural, polymer, and synthetic ones, as well as formulation methods, applications, and various parameters of oral disintegrating tablets. These tablets are particularly well-liked by pediatric patients and those who prefer generic medications. Oral disintegrating tablets are highly preferred in the treatment of dysphagia and oral disorders among patients. Keywords: - Oral disintegrating tablets, Oro disintegrating tablets, Disintegrates, Super disintegrates and Fast dissolution tablet.
4
Prachi, Pawar* Akanksha Jadhav Gayatri Ghodke Vidya Anap Dr. Sanjay Ingale. "Review On Fast Dissolving Tablets." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 1748–60. https://doi.org/10.5281/zenodo.14011672.
Full textAbstract:
The fast dissolving tablet (FDT) is a new and unique drug delivery system that is rapidly focusing major attention in the reasearch field of fast dissolving technology. In recent times, a few solid dosage forms, such as tablets and capsules, are dealing with issues such dysphagia, which causes difficulties swallowing and leads to a high rate of non-compliance, ultimately causing the therapy ineffective.Fast dissolving tablet are disintegrating or/and dissolve quickly without the need of water. These tablets are designed to dissolve or break down in saliva in the mouth, usually in less than 60 seconds.These fast dissolving tablet having many advantages such as easy portability and manufacturing, precise dosage, superior chemical and physical stability, and an excellent substitute for both pediatric and elderly patients.For a drug to be formulated as a Fast Dissolving Tablet, it must satisfy four criteria: high stability in aqueous media, low dose, appropriate mechanical strength, and compatibility with excipients. As day’s passes, demand for the faster disintegrating formulation is increased. So, the pharmacist needs to formulate disintegrants i.e. super disintegrants which are effective at low concentration and have greater disintegrating efficiency, and they are more effective intragranular.This review describes the various advantages, excipients used,super-disintegrate employed,drugs eligible for FDTs, different techniques used for preparing FDT, various patented technologies, evaluation parameters.
5
Singhal, Peeush. "OPTIMIZED FAST DISINTEGRATING TABLETS, BOOSTED OSELTAMIVIR PHOSPHATE ORALLY FAST DISINTEGRATING TABLETS." Journal of Medical pharmaceutical and allied sciences 10, no. 6 (2021): 3781–88. http://dx.doi.org/10.22270/jmpas.v10i6.1479.
Full textAbstract:
Background Around 33% of the populace (fundamentally pediatric and geriatric) has gulping hardships, bringing about helpless consistence with oral tablet drug treatment which prompts decreased in general treatment viability. For this explanation, tablets that can quickly break down or deteriorate in the oral cavity have drawn in a lot of consideration. Objective research was designed to develop and evaluate boosted orally fast disintegrating tablets (OFDT) for oro-buccal drug delivery of oseltamivir phosphate. Methods In the present study six formulations of mouth dissolving tablet of oseltamivir were prepared by direct compression method using SSG as a super disintegrating agent with lactose, talcum, mannitol, SLS and starch. The prepared tablets were then subjected to various evaluation parameters. Results every one of the outcomes was observed to be inside satisfactory reaches. The formulation F6 manufacturing utilizing SSG 50mg and SLS 10mg showed the higher medication content (98%), while the formulation F2 showed the least medication content (92%). It was seen that with the increment in SSG concentration, the medication content was additionally increased. SEM concentrate on showed request of expanding unpleasantness of tablet surface is F1<F2<F3<F4<F5<F6. The expanding unpleasantness may be answerable for higher % of medication release. Formulation F1 showed the most elevated medication discharge (97.735%), while the formulation F5 showed the least medication discharge (56.24%). Finally, it was inferred that SSG, SLS, D-mannitol, starch, lactose, and talcum powder can be effectively utilized in the formulation of Oseltamivir phosphate mouth dissolving tablets. Conclusion: From the above work it was presumed that the formulation of the Oseltamivir Phosphate was observed to be more achievable than the regular one.
6
Jain, P., A. Mishra, and A. Pathak. "PREPARATION & EVALUATION OF ORODISPERSIBLE TABLET CONTAINING ASPIRIN BY SUBLIMATION METHOD." INDIAN DRUGS 52, no. 12 (2015): 60–62. http://dx.doi.org/10.53879/id.52.12.10465.
Full textAbstract:
Orodispersible tablets are uncoated tablets which when taken into the mouth, get easily dispersed within 3 min before swallowing. they are also known as orally disintegrating tablets, mouth-dissolving tablets, rapid dissolving tablets fast-disintegrating tablets, fast-dissolving tablets. In this work, sublimation process was used to prepare orodispersible tablets of aspirin by formulating various batches using different concentration of sodium starch glycolate, camphor and cross povidone. An effort was made by using two modes, first, to increase water uptake for the fast dispersion by creating pores by sublimation methods in tablets and second, use of super disintegrantes like sodium starch glycolate to minimise disintegration time and promote fast dispersing ability. Prepared formulations were evaluated for weight variation, content uniformity, friability, hardness, wetting time, disintegration time, in vitro drug release and interaction study by differential scanning calorimetery. The best formulation was selected on the basis of evaluation results.
7
Krishna, Pandey Manju, and Gupta Amresh. "Fast dissolving tablets: Opportunity in herbal drug delivery system." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 102–13. https://doi.org/10.5281/zenodo.13120020.
Full textAbstract:
The polyherbal preparation's pharmacological and phytochemical properties have been used all over the world. Single or multiple herbs (polyherbal) are utilized for treatment in Ayurveda. The Sarangdhar Samhita, a work of Ayurvedic literature, emphasized the idea of polyherbalism as a means of enhancing therapeutic efficacy. Individual plants' active phytochemical components are insufficient to produce the desired therapeutic effects. The medicinal effects and toxicity are improved when different herbs are combined in a specific ratio. Comforts of drug administration and patient compliance are given significant weight when designing dose forms. New and developing technology can be used to produce durable, adaptable tablets with exceptional flavor masking and controlled release. Orally disintegrating tablets (ODTs) are solid dosage forms that disintegrate in the mouth in less than 60 s, and are thus swallowed without the need for water. Rapid disintegration of tablet cause quick dissolution thus rapid onset of action. Polyherbal Fast dissolving Tablets disintegrates in mouth quickly and produces fast onset of action without use of water makes it suitable for special population like pediatrics, geriatrics, psychotic, dysphasic, bedridden patient and frequent traveller patient. The current review article explains the features of active ingredients and excipient used in the formulation of ODTs, discusses multiple ODT formulation and preparation techniques with their merits and demerits, and also, offers remedies for problems associated with ODTs. Moreover, quality control steps and required considerations are presented.
8
Raziya, Begum Sheikh. "Development and Assessment of Naproxen Mouth Dissolving Tablets." medtigo Journal of Pharmacology 1, no. 1 (2024): e13377773. https://doi.org/10.5281/zenodo.13377773.
Full textAbstract:
The market demand for orally disintegrating tablets has experienced a significant surge over the past decade. This intervention is particularly beneficial for geriatric and pediatric patients who experience challenges in ingesting traditional tablets and capsules. The utilization of a fast dissolving or fast disintegrating dosage form confers advantages to patients in this context. Fast dissolvable or fast disintegrating dosage forms are designed to rapidly disintegrate upon exposure to saliva, resulting in accelerated drug release within the oral cavity. The administration of fast-disintegrating dosage forms facilitates the absorption of drugs through the buccal mucosa, potentially resulting in a reduction of first pass metabolism and consequently enhancing the desired drug efficacy. The objective of this study was to create six different formulations (F1, F2, F3, F4, F5, and F6) of naproxen MDT through the direct compression method, utilizing different concentrations of super disintegrants. A range of pre-formulation and post formulation evaluation studies were conducted, including compatibility studies, bulk density analysis, tapped density determination, angle of repose assessment, cars index evaluation, hausner's ratio weight variation analysis, hardness assessment, friability evaluation, drug content assessment, wetting time analysis, in vitro dissolution analysis, in-vitro dispersion technique analysis, and water absorption ratio analysis. The drug release in vitro examination of formulation F4, which incorporates cross povidone as a super disintegrant, demonstrated the highest level of drug release in comparison to the other formulations. A study was conducted to determine the feasibility of preparing MDT with enhanced naproxen dissolution through the direct compression method, incorporating super disintegrants. This study facilitated comprehension of the impact of formulation processing variables, particularly the super-disintegrant, on the formulation's drug release profile.
9
Rupali, Patel, Upadhyay Nikita, Sonartiya Sunita, Jain Sourabh, and Dubey P.K. "Formulation and Evaluation of Gastro Retentive Drug Delivery System of Domperidone Mouth Dissolving Tablet by using Super Disintegrating Agents." International Journal of Pharmaceutical Sciences and Medicine 8, no. 3 (2023): 42–66. http://dx.doi.org/10.47760/ijpsm.2023.v08i03.004.
Full textAbstract:
Direct compression method can be considered as an important method for the formulation of fast dissolving tablets of Domperidone compare to wet granulation method. The rank order for the best 3 formulations is F2>F1. Formulation F2 having DCP as the super disintegrant is the best formulation of all. Higher the concentration of the lubricating agent (Magnesium Stearate or Talc), higher will be the disintegration time. Formulation having the better Super disintegrants (Ac-Di-Sol) will have better in vitro disintegration time and dissolution along with lesser friability and weight variation. Thus, it may be concluded that the fast-dissolving tablets of Domperidone can be successfully prepared and undoubtedly the availability of various technologies and manifold advantages of fast dissolving tablets will surely enhance patient compliance and its popularity in the near future.
10
Birajdar, Shivprasad M., Omprakash G. Bhusnure, and Suraj S. Mulaje. "FORMULATION AND EVALUATION OF FAST DISINTEGRATING LOSARTAN POTASSIUM TABLETS BY FORMAL EXPERIMENTAL DESIGN." International Journal of Drug Regulatory Affairs 2, no. 2 (2018): 61–77. http://dx.doi.org/10.22270/ijdra.v2i2.132.
Full textAbstract:
In the treatment of hypertension fast onset of action is the major concern. The problem of slow onset of action of drugs can be overcome by development of appropriate dosage forms. Fast disintegrating tablets in mouth are best suited and have gained popularity in the oral antihypertensive drug therapy. These are advantageous over other conventional systems in terms of patient compliance, rapid onset of action, accurate dosing, good chemical stability, convenience of self-administration and compactness. Losartan potassium is widely used as an antihypertensive drug, which is a potent drug candidate for developing in to Fast Dissolving Tablets (FDT’s). It has low bioavailability due to first pass metabolism. Hence the main objective of the study was to formulate fast dissolving tablets of Losartan potassium to achieve a better dissolution rate and further improving the bioavailability of the drug. Fast dissolving tablet of Losartan potassium were formulated by using microcrystalline cellulose with different concentration of super disintegrants like sodium starch glycolate and Isabgol Mucilage. All the batches were prepared by direct compression.
 API characterization studies were conducted to check the purity of API .The tablets were evaluated for Pre compression parameters and post compression parameters. Before the formulation of the tablets IR spectroscopic studies were also performed to check the compatibility with the excipients.
 A 23 full factorial design was applied to investigate the combine effect of 3 formulation variables. Here the concentration of Isabgol mucilage, concentration of Sodium Starch Glycolate and concentration of Microcrystalline Cellulose were taken as independent variable X1, X2 & X3 respectively and their effect of disintegration time is studied as dependent parameter. To represent the data Design Expert software is used.
Book chapters on the topic "Fast Disintegrating Tablets Super-Disintegrants Mouth Disintegrating Tablets"
1
Noothi, Sadhana, Narender Malothu, and P. Vishnu. "Formulation and Characterization of Bilastine Oral Disintegrated Tablets Using Natural and Synthetic Super Disintegrants." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00361.
Full textAbstract:
Bilastine (BLS) is a second-generation H1- antihistamine that is approved recently for the symptomatic treatment of chronic urticaria. The present investigation was to develop oral disintegrating tablets of BLS to produce a fast onset of action. In this study, an attempt was made to compare the effect of different natural and synthetic super disintegrants on the release profile of the formulation. The formulations (BF1-BF15) of BLS oral disintegrating tablets were prepared by direct compression technique using synthetic and natural super disintegrants (Chitosan, Fenugreek mucilage, Sodium starch glycolate, Ludiflash, Cross povidone) in three different concentrations (2, 4, and 6%). The formulated tablets were analyzed for pre-compression and post-compression parameters and in vitro drug release. The best formulation, F15 containing 6% Ludiflash as a super disintegrant, was found to have a maximum water absorption ratio and disintegration time and in vitro dissolution was found to be less than 5 min, ensuring faster disintegration and dispersion. The F15 formulation shows less disintegration and dispersion time because of its combined effect and formulation, which had a better drug release of 99.79% within 20 min. The dissolution pattern of various disintegrants used in the formulation was found to be in the order of Ludiflash&gt;Cross povidone&gt;chitosan&gt;SSG&gt;Fenugreek mucilage. Overall, the results show that the formulated oral disintegrating tablets of BLS with Ludiflash as a super disintegrant, indicating that this could be a feasible drug delivery for BLS.