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Journal articles on the topic 'Fast Disintegrating Tablets Super-Disintegrants Mouth Disintegrating Tablets'

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Published: 5 June 2025

Last updated: 15 July 2025

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1

M, Nandhini, Vijaya Kumar Voleti, Ramesh Yamuna, et al. "Applications of the Natural Polymers for Fast Dissolving Tablets." International Journal of Clinical Pharmacokinetics and Medical Sciences 4, no. 1 (2024): 34–40. http://dx.doi.org/10.26452/ijcpms.v4i1.584.

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Oral route is the safest, most convenient, and economical route for administration of different drugs. Oral disintegrating tablets becoming very popular in the current scenario, as they facilely disintegrated in mouth within fewseconds of the time after its administration withoutthe need of water. Conventional dosage form has a limitations like dysphagia (arduousness in swallowing), in pediatric and geriatric patients, which have been overcome by oral disintegrating tablets. To prepare the same super disintegrating agents plays vital role. Natural Super disintegrants gained an advantage over t

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C., Haranath* T. Srikanth M. Suresh Krishna G. Chaithanya Barghav C. Mahesh Reddy. "FORMULATION AND INVITRO EVALUATION OF FAST DISINTEGRATING TABLETS OF AN ANTI-INFLAMMATORY DRUG." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 10790–99. https://doi.org/10.5281/zenodo.3229226.

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<em>Oral disintegrating tablets are defined as the tablets that disperse or disintegrates in less than one minute in the mouth prior to being swallowed, which results in the rapid dissolution and absorption of the active pharmaceutical ingredient contained in the tablet, providing rapid onset of action. Aceclofenac is a poorly water-soluble drug. The solubility of the drug was enhanced by solid dispersion technique using mannitol as the carrier. In the present study, 9 formulations were developed by using different super disintegrants like cross povidone, sodium starchglycolate and cross carme

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Sneha, Ms Shinde. "Review Article A Detailed Study on Disintegrating Agents and an Overview on Oral Disintegration Tablet." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 04 (2024): 1–5. http://dx.doi.org/10.55041/ijsrem30535.

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Nowadays, the administration of drugs through the oral route is becoming less common, accounting for only about 75% of all drug administrations compared to other routes. A new type of dosage form called oral disintegrating tablets has gained popularity in recent decades due to their rapid disintegration and dissolution. These tablets disintegrate in the mouth within seconds (25-40 seconds) without the need for water, as the oral mucosa alone is sufficient for the tablet to dissolve. The selection of a suitable disintegrating agent is crucial to achieve optimal bioavailability. A preparation ma

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Prachi, Pawar* Akanksha Jadhav Gayatri Ghodke Vidya Anap Dr. Sanjay Ingale. "Review On Fast Dissolving Tablets." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 1748–60. https://doi.org/10.5281/zenodo.14011672.

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The fast dissolving tablet (FDT) is a new and unique drug delivery system that is rapidly focusing major  attention in the reasearch field of fast dissolving technology. In recent times, a few solid dosage forms, such as tablets and capsules, are dealing with issues such dysphagia, which causes difficulties  swallowing and leads to a high rate of non-compliance, ultimately causing the therapy  ineffective.Fast dissolving tablet are disintegrating or/and dissolve quickly without the need of water. These tablets are designed to dissolve or break down in saliva in the mouth, u

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Singhal, Peeush. "OPTIMIZED FAST DISINTEGRATING TABLETS, BOOSTED OSELTAMIVIR PHOSPHATE ORALLY FAST DISINTEGRATING TABLETS." Journal of Medical pharmaceutical and allied sciences 10, no. 6 (2021): 3781–88. http://dx.doi.org/10.22270/jmpas.v10i6.1479.

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Background Around 33% of the populace (fundamentally pediatric and geriatric) has gulping hardships, bringing about helpless consistence with oral tablet drug treatment which prompts decreased in general treatment viability. For this explanation, tablets that can quickly break down or deteriorate in the oral cavity have drawn in a lot of consideration. Objective research was designed to develop and evaluate boosted orally fast disintegrating tablets (OFDT) for oro-buccal drug delivery of oseltamivir phosphate. Methods In the present study six formulations of mouth dissolving tablet of oseltami

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Jain, P., A. Mishra, and A. Pathak. "PREPARATION & EVALUATION OF ORODISPERSIBLE TABLET CONTAINING ASPIRIN BY SUBLIMATION METHOD." INDIAN DRUGS 52, no. 12 (2015): 60–62. http://dx.doi.org/10.53879/id.52.12.10465.

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Orodispersible tablets are uncoated tablets which when taken into the mouth, get easily dispersed within 3 min before swallowing. they are also known as orally disintegrating tablets, mouth-dissolving tablets, rapid dissolving tablets fast-disintegrating tablets, fast-dissolving tablets. In this work, sublimation process was used to prepare orodispersible tablets of aspirin by formulating various batches using different concentration of sodium starch glycolate, camphor and cross povidone. An effort was made by using two modes, first, to increase water uptake for the fast dispersion by creating

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Krishna, Pandey Manju, and Gupta Amresh. "Fast dissolving tablets: Opportunity in herbal drug delivery system." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 102–13. https://doi.org/10.5281/zenodo.13120020.

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The polyherbal preparation's pharmacological and phytochemical properties have been used all over the world. Single or multiple herbs (polyherbal) are utilized for treatment in Ayurveda. The Sarangdhar Samhita, a work of Ayurvedic literature, emphasized the idea of polyherbalism as a means of enhancing therapeutic efficacy. Individual plants' active phytochemical components are insufficient to produce the desired therapeutic effects. The medicinal effects and toxicity are improved when different herbs are combined in a specific ratio. Comforts of drug administration and patient compliance are

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Raziya, Begum Sheikh. "Development and Assessment of Naproxen Mouth Dissolving Tablets." medtigo Journal of Pharmacology 1, no. 1 (2024): e13377773. https://doi.org/10.5281/zenodo.13377773.

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The market demand for orally disintegrating tablets has experienced a significant surge over the past decade. This intervention is particularly beneficial for geriatric and pediatric patients who experience challenges in ingesting traditional tablets and capsules. The utilization of a fast dissolving or fast disintegrating dosage form confers advantages to patients in this context. Fast dissolvable or fast disintegrating dosage forms are designed to rapidly disintegrate upon exposure to saliva, resulting in accelerated drug release within the oral cavity. The administration of fast-disintegrat

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Rupali, Patel, Upadhyay Nikita, Sonartiya Sunita, Jain Sourabh, and Dubey P.K. "Formulation and Evaluation of Gastro Retentive Drug Delivery System of Domperidone Mouth Dissolving Tablet by using Super Disintegrating Agents." International Journal of Pharmaceutical Sciences and Medicine 8, no. 3 (2023): 42–66. http://dx.doi.org/10.47760/ijpsm.2023.v08i03.004.

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Direct compression method can be considered as an important method for the formulation of fast dissolving tablets of Domperidone compare to wet granulation method. The rank order for the best 3 formulations is F2>F1. Formulation F2 having DCP as the super disintegrant is the best formulation of all. Higher the concentration of the lubricating agent (Magnesium Stearate or Talc), higher will be the disintegration time. Formulation having the better Super disintegrants (Ac-Di-Sol) will have better in vitro disintegration time and dissolution along with lesser friability and weight variation. T

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Birajdar, Shivprasad M., Omprakash G. Bhusnure, and Suraj S. Mulaje. "FORMULATION AND EVALUATION OF FAST DISINTEGRATING LOSARTAN POTASSIUM TABLETS BY FORMAL EXPERIMENTAL DESIGN." International Journal of Drug Regulatory Affairs 2, no. 2 (2018): 61–77. http://dx.doi.org/10.22270/ijdra.v2i2.132.

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In the treatment of hypertension fast onset of action is the major concern. The problem of slow onset of action of drugs can be overcome by development of appropriate dosage forms. Fast disintegrating tablets in mouth are best suited and have gained popularity in the oral antihypertensive drug therapy. These are advantageous over other conventional systems in terms of patient compliance, rapid onset of action, accurate dosing, good chemical stability, convenience of self-administration and compactness. Losartan potassium is widely used as an antihypertensive drug, which is a potent drug candid

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Izzalddin, Rawand, and Nozad Hussein. "Effect of kyron T-134 and crospovidone as a fast disintegrating agent on formulation properties of fast dissolving tablet containing ketorolac and rizatriptan using direct compression method." Zanco Journal of Medical Sciences 28, no. 2 (2024): 207–22. http://dx.doi.org/10.15218/zjms.2024.21.

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Background and objective: Fast dissolving tablets (FDTs) are "they are uncoated tablets that are supposed to be placed in the mouth and dispersed quickly before being swallowed" within minutes. This study aimed to formulate and evaluate a combination of ketorolac and rizatriptan as orally fast-dissolving tablets using the most common and easiest method to treat migraine attacks with or without aura. To investigate the effects of various types of diluents and super disintegrants on wetting time, water absorption ratio, disintegration, and dissolution time of combined drugs (ketorolac and rizatr

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Disha, Wankhede* Damini Mundhare. "Formulation And Evaluation Of Oral Dispersible Tablet Containing Giloy." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 342–50. https://doi.org/10.5281/zenodo.14045993.

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Tablets, the most common drug delivery system, provide the opportunity to incorporate new technologies to produce more dosage forms. Orally dispersible drug delivery systems are widely used to improve bioavailability and patient compliance. Orally dispersible tablets (ODT) have been developed for children, the elderly, bedridden patients, and patients without access to water. In fact, swallowing problems develop in young people due to weakening of muscles and nerves. In some cases, such as cold, cough and inability to drink, tablets may be difficult or uncomfortable to swallow. ODT creates a s

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Singh, Gurpreet, Jayesh Dwivedi, Jeyabalan Govindasamy, Naresh Kalra, and Rajesh Sharma. "Formulation of Mouth Dissolving Tablets Using Solid Dispersion Technique: A Review." Indian Journal of Pharmaceutical and Biological Research 6, no. 03 (2018): 66–72. http://dx.doi.org/10.30750/ijpbr.6.3.11.

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Mouth-dissolving tablets are also called as fast disintegrating tablets, melt-in mouth tablets, orodispersible tablets, quick dissolving etc. Mouth dissolving tablets are those when put on tongue disintegrate rapidly thereby releasing the drug, which dissolve or disperses in the saliva. The faster the drug dissolved into solution, quick will be the absorption and onset of clinical effect. Mouth dissolving tablet containing solid dispersion was developed to improve the solubility of drug and stability of solid dispersion. Such tablets are disintegrate and/or dissolve rapidly in the saliva witho

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Das, Pratik Swarup, Sushma Verma, and Puja Saha. "FAST DISSOLVING TABLET USING SOLID DISPERSION TECHNIQUE: A REVIEW." International Journal of Current Pharmaceutical Research 9, no. 6 (2017): 1. http://dx.doi.org/10.22159/ijcpr.2017v9i6.23435.

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Fast dissolving tablets are also called as mouth-dissolving tablets, melt-in mouth tablets, orodispersible tablets, quick dissolving etc. Fast dissolving tablets are those when put on tongue disintegrate instantaneously releasing the drug, which dissolve or disperses in the saliva. The faster the drug dissolved into solution, quicker the absorption and onset of clinical effect. Oral routes of drug administration have wide acceptance up to 50-60% of total dosage forms. Fast dissolving tablet containing solid dispersion was developed to improve the dissolution of drug and stability of solid disp

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Kiran, Mahadeo Salunke, Umakant Veer Sujata, Ankush Narute Yogesh, Babusha Pawar Pratiksha, and Navnath Khedkar Amol. "Various drugs used in oral disintegration tablet formulation." World Journal of Advanced Research and Reviews 24, no. 1 (2024): 459–76. https://doi.org/10.5281/zenodo.15010256.

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Oral drug administration is more widely accepted because it is used to provide between 50 and 60 percent of medications. The solid dosage forms are commonly utilized since they are simple to administer, precise in their dosage forms, beneficial for self-medication, and preventive of discomfort, and last but not least, the excellent level of patient adherence. The capsules and tablets are the most widely used solid dose form administered orally. Aside from ingesting it does not possess any noteworthy drawbacks. Water plays a crucial function in this swallowing process. Even following this, some

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M., Maheshwar. "PHYTOCHEMICAL SCREENING AND TLC FINGERPRINTING FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLETS OF FENOFIBRATE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 01 (2018): 318–25. https://doi.org/10.5281/zenodo.1154121.

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Fenofibrate is a drug of the fibrate class. It is a widely used hypolipidemic drug. The poor aqueous solubility of the drug leads to variable dissolution rates. It is slightly soluble in water. Fast disintegrating tablets (FDTs) of Fenofibrate were prepared using different concentrations of superdisintegrants using wet granulation method. The technique is to increase the bioavailability of the tablets and drug release in the patients. The porous granules were then compressed in to tablets. The blend was examined for angle of repose, bulk density, tapped density, compressibility index and Hausn

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Nitish, Gaur* Rajan Kothari. "A comprehensive review on fast dissolving pantoprazole tablet: a promising approach for drug delivery." International Journal of Advances in Pharmacy Medicine and Bioallied Sciences 10, no. 3 (2022): 101–7. https://doi.org/10.5281/zenodo.7708959.

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Besides creating an easy-to-use dosage form for treatment, a revolutionary drug delivery system will increase the safety and effectiveness of therapeutic molecules and improve patient compliance. One such strategy resulted in the creation of fast-dissolving tablets. Fast-dissolving tablets (FDTs) are becoming more and more important today as a result of the variety of medications they can be used for. These are revolutionary tablet forms that dissolve/disperse/disintegrate in saliva in under 60 seconds without chewing or additional water. A popular proton-pump inhibitor (PPI) in clinics and ot

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Shaikh, Siraj Nawaj* Shaikh Heena Kausar G. J. Khan Tajammul Khan. "INSIGHT IN TO USE OF CO PROCESS EXCIPIENTS IN ORAL DISINTEGRATING TABLETS-REVIEW ARTICLE." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2622–26. https://doi.org/10.5281/zenodo.858669.

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Fast Disintegrating tablets have started gaining popularity and acceptance as new drug delivery systems, because t hey are easy to administer. Recent development in fast disintegrating technology mainly works to improve the disint egration quality of these delicate dosage forms without affecting their integrity. Oral disintegrating dosage form have facing many challenges which can be overcome by upcoming newly emerging approach of use of coprocess adujants in it. The developments or improvements in pharmaceutical process and equipments, particularly increase in production rates at low cost, le

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Iswariya, V. T., Nambaaru Sailaja, CH Vamsi Krishna, and G. S. Annammadevi. "Natural Super-Disintegrant Agents Used in Various Oral Solid Dosage Forms." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 110–13. http://dx.doi.org/10.22270/jddt.v11i1.4681.

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Super-disintegrating agents are one of the ingredients used in pharmaceutical solid dosage forms. These substances play a vital role in formulation design. Natural super-disintegrants have gained more popularity due to their oral bioavailability. It disintegrates the tablets into smaller particles to enhance the dissolution rate. Fast dissolving, chewable tablets, and other orally administered dosage forms consist of super-disintegrating agents which shows rapid and quick action. Natural super disintegrating agents in pharmaceutical dosage forms are very effective due to their ecofriendly natu

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Nabila Nabila and Sry Ulina Karo-Karo. "Exploring natural disintegrant as alternative excipients sources for tablet formulation: A systematic review." International Journal of Science and Research Archive 13, no. 2 (2024): 3296–305. https://doi.org/10.30574/ijsra.2024.13.2.2530.

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Optimizing the disintegration and dissolution of orally administered tablets is crucial for releasing active pharmaceutical ingredients (APIs) for absorption. This review explores disintegrant research, focusing on natural super disintegrants and co-processed excipients that collected from 2010-2024. Natural disintegrants such as Silicified Oryza Sativa Starch, Plantago ovata mucilage, and gum karaya show promising results. Silicified Oryza Sativa Starch enhances paracetamol tablet disintegration, while Plantago ovata mucilage outperforms Crosspovidone. Gum karaya offers a cost-effective, bioc

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Gandhi, Lavika, and Md Semimul Akhtar. "Formulation and Characterization of Mouth Dissolving Tablet of Antiepileptic Drug using Natural Superdisintegrants." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 673–78. http://dx.doi.org/10.22270/jddt.v9i3-s.2950.

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MDTs is regarding as a good candidates for the patients with persistent nausea, who are traveling, or who have little or no access to water. The objective of present research work was to prepare and evaluate the mouth dissolving tablet of Lacosamide using Super disintegrants like Guar Gum, and other excipients like Microcrystalline Cellulose and Mannitol in different concentrations by Direct Compression method. Lacosamide has been shown to be an effective antiepileptic agent appropriate for the epilepsy patients. Effect of different formulation variables i.e. amount of polymer and type of poly

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Pommala, Nagaveni* A. Sreevalli G. Syam Sundar. "Fast Dissolving Tablets: An Overview." Int. J. in Pharm. Sci. 1, no. 7 (2023): 235–45. https://doi.org/10.5281/zenodo.8155035.

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The oral route is now the industry standard for drug delivery as it is recognized as the safest, least expensive, and most convenient method of achieving patient compliance. Rapidly dissolving tablets, a new idea for oral administration, is widely used and now accepted. These are solid dosage forms that dissolve and release the active ingredient when placed in the mouth without water for a short period of time. Geriatric, paediatric and bedridden patients are particularly favoured for the use of these FDTs because of dysphagia. Rapid absorption, quick onset of action and less drug loss propert

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Nagendra, R.1 Anusha B. H.2* Venkatesh K.3 Hanumanthachar Joshi4 Tanuja A. . J.5. "Innovations in Fast Disintegrating Tablet Formulation: Harnessing the Power of Super disintegrants for Rapid Oral Dissolution." International Journal in Pharmaceutical Sciences 2, no. 2 (2024): 380–91. https://doi.org/10.5281/zenodo.10673308.

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This work looks into how to improve the oral dissolving qualities of fast disintegrating tablets (FDTs) by formulating and testing them using cutting-edge super disintegrants. Modern super disintegrants have the ability to dissolve and disintegrate quickly in FDTs, which could be advantageous for patient convenience and compliance. To maximize tablet disintegration times, a variety of super disintegrants were used, such as sodium starch glycolate, crospovidone, and croscarmellose sodium. Excipients such binders, diluents, and sweeteners were carefully chosen to ensure compatibility and maintai

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Fahmansyah, Lingga Pratama, Agus S, and Suparman. "REVIEW : OF SUPERDISINTEGRANT INGREDIENTS IN FAST DISINTEGRANT TABLET TABLET PREPARATIONS." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 3 (2024): 857–76. http://dx.doi.org/10.37874/ms.v9i3.1292.

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This study aimed to evaluate the potential of synthetic and natural disintegrating agents in fast-disintegrating tablet (FDT) formulations. The methodology used includes a comprehensive literature review on the definition, characteristics, working mechanisms, and applications of super disintegrants in the manufacture of FDTs. The results of the study showed that super disintegrants play an important role in facilitating rapid disintegration of tablets. Synthetic super disintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate have the advantage of lower concentratio

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Pethe, Anil M., A. T. Patil, D. R. Telange, and A. A. Tatode. "Development and Evaluation of Novel Fast Disintegrating Acetaminophen Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 1 (2015): 2748–55. http://dx.doi.org/10.37285/ijpsn.2015.8.1.7.

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In this study, attempts were made to design and developed disintegrating drug delivery system, Acetaminophen fast disintegrating tablet (AFDT) by combining super disintegrants and direct compression method. Acetaminophen is widely used as “over the counter” and “common household drug” as analgesic and antipyretic along with poor absorption due to first pass metabolism. So we aimed to use our novel delivery system to achieve rapid absorption in patients like mentally ill, bed ridden and those who do not have easy access to water. The (AFDT) were produced by combining three super disintegrants v

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Dr., G. Nagaraju, Sirisha V., Ramakrishna Kavati, and Hareesh Dara Dr. "FORMULATION AND EVALUATION OF DEXIBUPROFEN FAST DISINTEGRATING TABLETS WITH NATURAL SUPER DISINTEGRANTS." Journal of Pharma Research 8, no. 12 (2019): 744–50. https://doi.org/10.5281/zenodo.14233228.

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<strong>Abstract</strong> <strong>I</strong>n this present research work, an attempt was made to develop solid dispersions for the enhancement of solubility, dissolution and bioavailability of Dexibuprofen and also to find the effect of natural super disintegrants in the development of quickly disintegrating tablets.Solid dispersions were prepared by solvent evaporation method using PEG 20,000as carrier in different ratios. The optimized solid dispersions were prepared in the form of quick disintegrating tablets using different natural super disintegrants in different concentrations. The prepa

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Harshal, Gosavi* Dr. Avish Maru Jayshree Bhadane Nilesh Pawar. "Formulation And Evaluation Fast Disintegrating Tablet: A Comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2257–69. https://doi.org/10.5281/zenodo.15407833.

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The pharmaceutical industry's demand for fast disintegration tablets (FDTs) has grown over the last few years, and the field is growing quickly. Fast dissolving tablets (FDTs) are solid dosages that dissolve rapidly on the tongue and absorb the drug with the need for water in a few seconds. FDTs have been developed for bedridden, elderly, and paediatric patients as well as active individuals who are on the go and may not having access to water. Due to hand tremors and dysphasia, many older people will have trouble swallowing traditional oral dosage forms, including tablets, capsules, and solut

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Kanaujiya, Sonu, and Sunil Kumar. "Comparative study of natural disintegrants, selection criteria for superdisintegrants." World Journal of Pharmaceutical Sciences 10, no. 05 (2022): 56–63. http://dx.doi.org/10.54037/wjps.2022.100503.

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Natural super disintegrants have been used for fast dissolving tablets because they are biodegradable, chemically inert, non-harmful, more affordable and widely available. The natural polymer improves the properties of the tablet as it is commonly used as diluents and binders. Super explosives are those substances that promote rapid decomposition in a lesser amount compared to explosives. Super disintegrants are the vehicles added to the tablet formulation to promote the breakdown of tablets and capsules into small microparticles in aqueous media, leading to an increase in surface area and pro

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Roman, Vaishnavi* Gaikwad Rutuja. "Development And Characterization of Lornoxicam Tablets Incorporating Banana Starch as A Superdisintegrating for Enhanced Dissolution." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2058–63. https://doi.org/10.5281/zenodo.15232534.

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Orally disintegrating tablets (ODTs) are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. ODTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. This type of property in dosage form can be attained by addition of different excipients, in which disintegrants are the key adjuvant. In recent years, several newer agents have been developed known as super-disintegrants. Super-disintegrants are used to improve the efficacy of solid dosage form and influence the release rate

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Purkayastha, Hrishav Das, and Bipul Nath. "FORMULATION AND EVALUATION OF ORAL FAST DISINTEGRATING TABLET OF IBUPROFEN USING TWO SUPER DISINTEGRANTS." International Journal of Current Pharmaceutical Research 9, no. 4 (2017): 92. http://dx.doi.org/10.22159/20966.

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Objective: The aim of the present investigation was to design and evaluate orally disintegrating tablet (ODT) of Ibuprofen, a NSAID drug used for the treatment of arthritis with a view to improve its oral bioavailability. The focus of the current study was to develop ODT of Ibuprofen using super disintegrants for ease of administration and its physicochemical characterization.Methods: Tablets were made from blends by direct compression method. All the ingredients were passed through mesh no. 80. All the ingredients were co-ground in a pestle motor. The resulting blend was lubricated with magne

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Kumar, Y. Shravan, R. Gowthami, Sujitha H, et al. "Formulation and Evaluation of Sumatriptan Succinate Fast Disintegrating Films and Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 2 (2013): 2087–96. http://dx.doi.org/10.37285/ijpsn.2013.6.2.11.

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Sumatriptan succinate is a 5-HT1B/1D receptor agonist which has well established efficacy in treating migraine. The main objective of the study was to formulate Oral Fast Disintegrating Films (ODF) and Oral Fast Disintegrating Tablets (ODT) to achieve a better dissolution rate and further improving the bioavailability of the drug. ODFs were prepared by solvent casting method using film forming polymers like HPMC – E15,5cps,50cps in different ratios & prepared batches of films were evaluated for the drug content, film thickness, disintegration time and in vitro dissolution studies. Among th

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Baijnath, Pal* Kavita Lovanshi Rita Mourya. "A Review on Fast Dissolving Tablet." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 3147–53. https://doi.org/10.5281/zenodo.15295648.

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The most common and preferred route of drug administration is through the oral route. Fast Dissolving tablets are gaining importance among novel oral drug-delivery system as they have improved patient compliance and have some additional advantages compared to other oral formulation. They are also solid unit dosage forms, which disintegrate in the mouth within a minute in the presence of saliva due to super disintegrants in the formulation. Thus this type of drug delivery helps a proper peroral administration in pediatric and geriatric population where swallowing is a matter of trouble. Various

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M., Anusha, Varun Raj S., Krishna Srewe P.V., Divya Deepthi N., Evanjiline Ch., and Roopa Koteswari Ch. "Formulation and Development of Rosuvastatin Fast Dissloving Tablets using Natural Super Disintegrates." Research & Review: Drugs and Drugs Development 1, no. 2 (2019): 61–77. https://doi.org/10.5281/zenodo.3271091.

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<em>Rosuvastatin is in category of the drug class. It is used to treat high cholesterol and to block cardiovascular disease. The main aim of this study is to develop oral dispersible tablets of Rosuvastatin using different types of super disintegrates to enhance the disintegration and dissolution of Rosuvastatin to improve bioavailability of the drug. Many trials were made to prepare a satisfactory rosuvastatin oral dispersible tablet using direct compression and wet granulation method. Formulate tablets were examine with different parameters such as weight variation, hardness, friability, wet

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Eraga, S. O., C. M. Okolo, B. U. Odionyenma, C. E. Mbadugha, and M. A. Iwuagwu. "A Comparative Evaluation of Fast Dissolving Tablets of Acetaminophen Using Super-disintegrant Blends and Sublimation Method." Journal of Phytomedicine and Therapeutics 19, no. 1 (2020): 375–86. http://dx.doi.org/10.4314/jopat.v19i1.3.

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Fast disintegrating tablets (FDTs) are gaining prominence as drug delivery systems and emerging as one of the popular and widely accepted dosage forms, especially for the peadiatric and geriatric patients. This study aims to evaluate and compare the tablet properties of fast disintegrating tablets of acetaminophen prepared by super-disintegrant blends and sublimation methods. Two groups of tablets comprising various batches were prepared by wet granulation. Granules batches of one group of tablets (A-G) were prepared with different concentrations of sodium starch glycolate and croscarmellose s

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Pradyumna Chaudhari, Shanti Saran Koiri, Ashish Lamsal, and Roshan Kumar Mehta. "Formulation and Evaluation of Fast Disintegrating Tablet of Salbutamol Sulphate." Journal of Universal College of Medical Sciences 12, no. 02 (2024): 29–33. http://dx.doi.org/10.3126/jucms.v12i02.69619.

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INTRODUCTION When put on the tongue, fast dissolving tablets immediately dissolve, often in a matter of seconds. They do not need any additional water to make them easier to swallow. Salbutamol sulphate fast disintegrating tablets have a higher bioavailability and dissolving rate. MATERIAL AND METHODS This experimental study was conducted in the Pharmaceutic laboratory of Department of Pharmacy at Universal College of Medical Sciences, Bhairahawa, Nepal from February 2022 to July 2022. A tablet was created utilizing the direct compression method employing mannitol as a diluent and various quan

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Dhakal, Bhawana, Jaybir Kumar Thakur, Reema Kumari Mahato, et al. "Formulation of Ebastine Fast-Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters." Scientific World Journal 2022 (May 19, 2022): 1–13. http://dx.doi.org/10.1155/2022/9618344.

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Ebastine is a long-acting, nonsedating, second-generation antihistaminic drug that prevents histamine action, mainly in immediate hypersensitivity. This project was aimed to formulate and characterize orodispersible tablets of ebastine, utilizing different proportions of three disintegrants, namely crospovidone, sodium starch glycolate, and coprocessed superdisintegrant. Initially, fifteen trial batches of ebastine orodispersible tablets were outlined using the central composite design of Minitab software. The tablets were formulated by the direct compression method. The compressed tablets wer

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Priyadarshan, Kalki Ranjan, Asish Sahu, Anjan Kumar Mahapatra, K. A. Chowdary, Ajit Nahak, and Ruchita Kumari Patra. "Rivaroxaban solid dispersions for dissolution enhancement and formulation of mouth disintegrating tablets." Journal of Applied Pharmaceutical Research 12, no. 4 (2024): 75–82. http://dx.doi.org/10.69857/joapr.v12i4.647.

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Background: Work is carried out to improve rivaroxaban's dissolution rate (DR) and develop mouth-disintegrating tablets for rapid onset of action. Objectives: The work objective was to improve the dissolution rate of rivaroxaban using PEG 6000 by preparing its solid dispersions (SDs) further to prepare mouth-disintegrating tablets (MDTs). Methods: Methods like physical mixing, melting, and solvent evaporation were used to prepare SDs at 1:0.5, 1:1, and 1:1.5 w/w ratios of rivaroxaban with PEG 6000 were prepared. Differential scanning calorimetry (DSC) and Infrared spectroscopy (IR) were used t

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Acharya, A., G. B. K. Kumar, P. Goudanavar, and K. Dhakal. "Various approaches to enhance the dissolution of Lornoxicam fast dissolving tablets prepared by using different categories of superdisintegrants: A comparative study." Journal of Manmohan Memorial Institute of Health Sciences 4, no. 1 (2018): 86–102. http://dx.doi.org/10.3126/jmmihs.v4i1.21147.

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Background: Recent developments in fast dissolving tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets.The main objective of the present study is to formulate fast dissolving tablet of Lornoxicam by direct compression method.Methods: Guar gum and crospovidone were used as natural and synthetic superdisintegrants respectively. Fast dissolving tablet of Lornoxicam were prepared by direct compression technique using three different approaches; superdisintegrant addition, sublimation, and solid dispersion.Results: IR and DSC studies s

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Narimane, Lammari, Mimoune Nada Yasmine, and Ouaret Amel. "Experimental Design for the Formulation and Optimization of Phloroglucinol Mouth Dissolving Tablets." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–06. https://doi.org/10.25258/ijddt.15.2.2.

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The purpose of the present study was to prepare and evaluate Phlorogluinol mouth dissolving tablets using experimental mixture design. Ten different formulations were generated based on three types of disintegrants (croscarmellose sodium, crospovidone and microcrystalline cellulose) by using simplex lattice design with Minitab 1.6® software. Tablets were prepared by direct compression technique. The percentage of drug release at 5min, 30 min and the disintegration time were statistically analyzed to get the optimized formulation. Drug content, hardness, friability and mass uniformity were carr

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K, Venkatesh, Ramu B, and Rajkamal B. "Formulation and Evaluation of Risperidone Fast Disintegrating Tablets by Using Co- processed Superdisintegrants." Pharmaceutical and Chemical Journal 3, no. 2 (2016): 334–42. https://doi.org/10.5281/zenodo.13754623.

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In the present work, an attempt has been made to develop fast disintegrating tablets of Risperidone. Novel method of co processed super disintegrates technology was employed to formulate the tablets. All the formulations were prepared by direct compression method using 8mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the

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Chinnala, Krishna Mohan, and Sirish Vodithala. "FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF CINITAPRIDE HYDROGEN TARTARATE BY USING DIRECT COMPRESSION TECHNIQUE." International Journal of Current Pharmaceutical Research 9, no. 6 (2017): 98. http://dx.doi.org/10.22159/ijcpr.2017v9i6.23659.

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Objective: In the present study, efforts were taken to develop fast disintegrating tablets of Cinitapride hydrogen tartrate, is a gastro-prokinetic agent and antiulcer agent with an objective to achieve rapid disintegration, and further improving the bioavailability of the drug. Also, to resolve the swallowing problems (Dysphasia) in pediatric, geriatric patients by rapid disintegration in saliva and improve the patient compliance.Methods: Fast disintegrating tablets were prepared by direct compression method using superdisintegrants like crospovidone (CP), croscarmellose sodium (CCS), sodium

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Naji, Ghada Hamid, Worood Hameed Al-Zheery, and Noor Yousif Fareed. "DESIGN AND IN VITRO EVALUATION OF ACRIVASTINE AS ORODISPERSIBLE TABLET USING DIRECT COMPRESSION METHOD." Wiadomości Lekarskie 76, no. 1 (2023): 170–74. http://dx.doi.org/10.36740/wlek202301123.

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The aim: This study aimed to develop mouth-dissolving tablets of Acrivastine, an antihistamine medication, in order to increase its oral bioavailability. Materials and methods: Different super disintegrants, such as crospovidone, croscarmellose sodium, and sodium starch glycolate, were used to make Acrivastine oral dispersible tablets (ODTs). These super disintegrants were utilized in various concentrations. The formulation (F3) with 6% w/w crospovidone had a fast disintegration time (less than 30 seconds) and practically total drug release within 10 minutes. All of the formulations were made

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Khobragde, Deepak, Arun Kotha, K. Ravalika, Richa Gupta, and P. Vasu Kumar. "Oro-Dispersible Tablets of Ayurvedic Powder For improving Taste, Compliance, Ease and Accuracy of administration." International Journal of Advances in Scientific Research 2, no. 6 (2016): 131. http://dx.doi.org/10.7439/ijasr.v2i6.3458.

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Most of the ayurvedic medicines are in the form of powder. Being in powder form the administration of accurate dose with ease is a problem. They may have some kind of unacceptable bitter taste. Furthermore it needs water or honey for administration and chances of spoilage and waste are more. Oro-dispersible tablet which rapidly disintegrating in mouth will be the best remedy for efficient use of ayurvedic powders. The aim of this study was to formulate oro-dispersible tablets of ayurvedic polyherbal powder Talisadi. Talisadi is a traditional Ayurvedic powder preparation well known and effectiv

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Masih, Ashish, and Ajay Kumar Tiwari. "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF AMOXYCILLIN TRIHYDRATE AND POTASSIUM CLAVULANATE." International Journal of Current Pharmaceutical Research 9, no. 2 (2017): 48. http://dx.doi.org/10.22159/ijcpr.2017v9i2.17385.

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Objective: The present work is aimed to formulate fast dissolving stable tablet formulation a preferred combination of Amoxycillin trihydrate (Beta-lactum antibiotic) and Potassium clavulanate (Beta-lactum inhibitor) by using various super disintegrants.Methods: Fast dissolving tablets are prepared by direct compression method using super disintegrants i.e. sodium starch glycolate, crospovidone, croscarmellose sodium. Aspartame as a sweetener and trusil mango flavor were used to increase palatability. Reduction in the dose of Amoxycillin trihydrate and Potassium clavulanate tablet was possible

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Pawar, Harshala, Aishwarya Pawar, and Shraddha N. Bhavsar. "FAST DISINTEGRATING TABLETS - A NEW ERA IN NOVEL DRUG DELIVERY SYSTEM." International Journal of Advanced Research 10, no. 01 (2022): 94–109. http://dx.doi.org/10.21474/ijar01/14018.

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Among all dosage forms, fast-Disintegrating tablets are one of the most commonly used dosage forms, especially in children, because their nervous system and muscular system are not well developed compared to them in adults. and in adult patients with Parkinsons disease or hand tremors. Some fixed dosage forms, such as capsules and tablets, now have difficulty swallowing (dysphagia), which results in many cases of non-compliance and renders therapy ineffective. The most preferred routes of administration for various drugs are oral dosage forms and the oral route with specific limitations such a

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M Mahesh, Mahesh, Harish K H Harish, Fatima Sanjeri Dasankoppa, et al. "Formulation and Evaluation of Fast Disintegrating Tablets of Antihistamine Drug Using Natural Super Disintegrants." Journal of Young Pharmacists 16, no. 4 (2024): 762–71. http://dx.doi.org/10.5530/jyp.2024.16.96.

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Shah, Ria, Disha Patel, Dhruvanshi Kothari, et al. "Formulation and Evaluation of Oral dispersible Tablet of Paroxetine Hydrochloride." Journal of Drug Delivery and Therapeutics 11, no. 4 (2021): 41–47. http://dx.doi.org/10.22270/jddt.v11i4.4921.

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Orodispersible tablets (ODTs) is one such novel approach which helps to increase user acceptance by virtue of rapid disintegration, self-administration without water or chewing. ODTs are solid unit dosage forms like the conventional tablets containing super disintegrants, which help them to disintegrate and/or disperse rapidly in the mouth within few seconds. The orodispersible tablet of Paroxetine hydrochloride was prepared by using direct compression method and the tablet were formulated using various concentration of Kyron T-314 as disintegrating agent, PVP K-30 as binder, F melt Type C as

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Dhiman, Jasmine, Dhruv Dev, and D. N. Prasad. "Superdisintegrants: Brief Review." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 170–75. http://dx.doi.org/10.22270/jddt.v12i1.5155.

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Oral disintegrating tablets are a new trend in novel drug delivery systems that have seen a surge in popularity in recent decades. To improve the efficacy of solid dosage forms, super disintegrants are used. This is accomplished by reducing the disintegration time, which improves the rate of drug dissolution. Disintegrants are substances or combination of substances added to a drug formulation to aid in the breaking up or disintegration of tablet or capsule content into smaller fragments that dissolve more quickly than without them. Several newer agents known as ‘Superdisintegrants’ have been

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Singh, Harmanpreet, Pooja Jaiswal, Suksham Gupta, and Simerjit Singh. "FORMULATION OF RIZATRIPTAN BENZOATE SUBLINGUAL TABLETS PREPARED BY DIRECT COMPRESSION WITH DIFFERENT BIOADHESIVE POLYMER: IN VITRO AND EX VIVO EVALUATION." Asian Journal of Pharmaceutical and Clinical Research 10, no. 16 (2017): 36. http://dx.doi.org/10.22159/ajpcr.2017.v10s4.21334.

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Objective: The current investigation deals with formulation and evaluation of fast disintegrating sublingual tablets of rizatriptan benzoate (RTB) to produce its intended therapeutic effect for acute treatment of migraine. When the drug is given by sublingual route, it overcomes the first pass metabolism and quick entry of drug in systemic circulation is obtained. It would result in fast pharmacological response hence faster relief from migraine which is an important criterion in migraine therapy.Methods: In this study, RTB sublingual tablets were prepared using direct compression process usin

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Anusha, B. H.*1 Nagendra R.2 Venkatesh3 Hanumanthachar Joshi K.4. "Formulation And Evaluation of Fast Disintegrating Tablet of Betaxolol Hydrochloride Using Super Disintegrants." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 362–76. https://doi.org/10.5281/zenodo.14050550.

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The study focused on developing a fast-disintegrating oral tablet of Betaxolol Hydrochloride aimed at treating hypertension through a direct compression method. Various formulations were tested using different concentrations of super disintegrants, with Microcrystalline cellulose serving as the diluent. Mannitol was utilized as a directly compressible diluent, while aspartame was chosen for its intense sweetness. Additionally, magnesium stearate and talc acted as lubricants, and aerosil was included to enhance flow properties. Pineapple flavor was added to improve the tablet's palatability. Th

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