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1

Schiermeier, Simone, and Peter Christian Schmidt. "Fast dispersible ibuprofen tablets." European Journal of Pharmaceutical Sciences 15, no. 3 (2002): 295–305. http://dx.doi.org/10.1016/s0928-0987(02)00011-8.

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2

Fini, Adamo, Valentina Bergamante, Gian Carlo Ceschel, Celestino Ronchi, and Carlos Alberto Fonseca de Moraes. "Fast dispersible/slow releasing ibuprofen tablets." European Journal of Pharmaceutics and Biopharmaceutics 69, no. 1 (2008): 335–41. http://dx.doi.org/10.1016/j.ejpb.2007.11.011.

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3

Kumar, Voleti Vijaya, Nandhini M, Sreelekhaa T, et al. "Comprehensive Review of Oro Dispersible Tablets and Co Processed Super disintegrants." Future Journal of Pharmaceuticals and Health Sciences 4, no. 1 (2024): 1–13. http://dx.doi.org/10.26452/fjphs.v4i1.548.

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Due to their ease of administration, self-administration, and improved patient compliance, solid dosage forms are most popular. The most normally utilized strong dose structures are tablets and capsules, which is challenging for pediatric and geriatric patients. Considering these prerequisites endeavors have been made to foster rapid dissolving Tablets. The solid dosage form of a medicine that dissolves in a matter of seconds when swallowed is known as orodispersible tablet. The utilization of Superdisintegrants improves the crumbling season of the tablet. Fast Dissolving Tablets are generally
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4

V, Vijaya Kumar. "Comprehensive Review of Oro Dispersible Tablets and Co Processed Super disintegrants." Comprehensive Review of Oro Dispersible Tablets and Co Processed Super disintegrants 4, no. 1 (2024): 1–13. https://doi.org/10.5281/zenodo.14649969.

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Due to their ease of administration, self-administration, and improved patient compliance, solid dosage forms are most popular. The most normally utilized strong dose structures are tablets and capsules, which is challenging for pediatric and geriatric patients. Considering these prerequisites endeavors have been made to foster rapid dissolving Tablets. The solid dosage form of a medicine that dissolves in a matter of seconds when swallowed is known as orodispersible tablet. The utilization of Superdisintegrants improves the crumbling season of the tablet. Fast Dissolving Tablets are generally
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5

M., Anusha, Varun Raj S., Krishna Srewe P.V., Divya Deepthi N., Evanjiline Ch., and Roopa Koteswari Ch. "Formulation and Development of Rosuvastatin Fast Dissloving Tablets using Natural Super Disintegrates." Research & Review: Drugs and Drugs Development 1, no. 2 (2019): 61–77. https://doi.org/10.5281/zenodo.3271091.

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<em>Rosuvastatin is in category of the drug class. It is used to treat high cholesterol and to block cardiovascular disease. The main aim of this study is to develop oral dispersible tablets of Rosuvastatin using different types of super disintegrates to enhance the disintegration and dissolution of Rosuvastatin to improve bioavailability of the drug. Many trials were made to prepare a satisfactory rosuvastatin oral dispersible tablet using direct compression and wet granulation method. Formulate tablets were examine with different parameters such as weight variation, hardness, friability, wet
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6

Pokhrel, Gopal, Ganga Kunwar, Jun Devi Rai, Sheela Thapa, Sudip Dhakal, and Prashant Basnet. "Formulation and in-vitro Evaluation of Oro-dispersible tablets of Indomethacin." Nepal Journal of Health Sciences 2, no. 1 (2022): 90–97. http://dx.doi.org/10.3126/njhs.v2i1.47172.

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Introduction: Oro-dispersible tablets are rapidly dissolved in saliva without the need for water and are beneficial for renal impaired, bedridden and psychiatric patients. Objective: The study aimed to formulate oro-dispersible tablets of indomethacin with reduced adverse effects, better patient compliance, faster action, and convenience for patients. Methods: Oro-dispersible tablets of indomethacin were prepared using three different super disintegrants; crospovidone, croscarmellose sodium and sodium starch glycolate with three different concentrations (2.5%, 5.2%, and 7.7%) by direct compres
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7

Khan, MD Abdul Aali, M. S. Sudheesh, and Rajesh Singh Pawar. "Formulation Development and Evaluation of Oro-Dispersible Tablets Based On Solid Dispersion of Cimetidine." Journal of Drug Delivery and Therapeutics 12, no. 6-S (2022): 42–46. http://dx.doi.org/10.22270/jddt.v12i6-s.5696.

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The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach in a conventional dosage form which is oral dispersible tablet. Oral dispersible tablet is also called as mouth dissolving tablet, fast dissolving tablet, or oral disintegrating tablet. Oral dispersible tablet has advantage as it quickly disintegrates into saliva when it is put on the tongue. The faster the drug disintegrates or is dissolved, the faster the absorption and the quicker the therapeutic effect of drug will be attained. The objective of present study was to f
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8

R, Yogaraj, Surinder Kaur, and Padmaa M. Paarakh. "A Brief Introduction on Oro Dispersible Tablets." April-May 2023, no. 33 (April 10, 2023): 9–16. http://dx.doi.org/10.55529/jcpp.33.9.16.

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Oro dispersible tablets (ODTs), which have improved solubility and stability over the past three decades, have drawn a lot of interest as a superior alternative to traditional tablets and capsules. ODTs—solid dosage forms with medications that dissolve on the tongue fast, usually in a few seconds. New ODT technologies answer a wide range of pharmaceutical preparations and patient needs, to enhance the lifecycle management to straightforward dosage regimen for dysphagic, children, old, and mentally imbalanced patients. Methods for administering orally dispersible drugs are frequently used to im
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9

Mohammed Abdelrahman1,2*, Mohamed A. M. Elhassan1, Alaa Alsadig Alzain1, et al. "Formulation and Evaluation of Quinine sulfate Dispersible Tablets with Emphasis on Taste Masking using Cyclodextrin." Omdurman Journal of Pharmaceutical Sciences 2, no. 3 (2022): 275–85. http://dx.doi.org/10.52981/ojps.v2i3.2875.

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Dispersible tablets (DTs), also termed quick dissolving, fast melting, fast dissolving, fast disintegrating and rapid dissolving tablets, are uncoated or film-coated tablets intended to be dispersed in water before administration giving a homogeneous dispersion. Conventional quinine tablets have bitter taste when broken or dispersed to allow administration for children. Cyclodextrins (CDs) are cyclic oligosaccharides whose structural feature gives a hydrophobic interior and a hydrophilic exterior are widely used to increase the solubility of poorly soluble drugs. Recent studies showed that CDs
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10

Prajapat, Abhishek, Akash Yadav, and Dinesh Kumar Jain. "An Overview of Natural Disintegrating Agent Used in Dispersible Tablets." Asian Pacific Journal of Health Sciences 10, no. 2 (2023): 47–54. http://dx.doi.org/10.21276/apjhs.2023.10.2.12.

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The oral therapy is the most commonly used method for administering many medications since it is thought to be the safest, most practical, and least expensive method. Fast dissolving pills are highly popular right now because they dissolve or easily dissolve in the mouth after administration without the need for water. Fast dissolving tablets have been developed to address the drawbacks of conventional dose forms, particularly dysphagia (refers to problem in which it becomes difficult to swallow), in pediatric and geriatric patients. Natural materials offer an advantage in comparison to the sy
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11

Rajesh, Asija, Gupta Avinash, and Kumar Fardoliya Jitendra. "Development of Dispersible Aceclofenac Tablet Using Adsorbent." Pharmaceutical and Chemical Journal 2, no. 1 (2015): 31–40. https://doi.org/10.5281/zenodo.13692292.

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It has been reported that about 40% of the compounds being developed by the pharmaceutical industries are poorly water soluble. The limiting factor to the <em>in vivo </em>performance of poorly water soluble drugs after oral administration their inadequate ability to be wetted by and dissolved into the fluid in the gastrointestinal (GI) tract. Therefore, increasing the dissolution rate of poorly water soluble drugs is an important and significant challenge to pharmaceutical scientists in order to maximize absorption. Aceclofenac is a nonsteroidal anti-inflamatory drug (NSAID), used for rheumat
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12

A., Deevan Paul* P. Nagaraj E. Reshma T. Mahesh Y. Divyasree. "CHALLENGES IN NANOTECHNOLOGY DRUG DELIVERY SYSTEMS - STATE OF ART TECHNOLOGIES." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1550–58. https://doi.org/10.5281/zenodo.816203.

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The potential challenges to solve the poor solubility, limited chemical stability in vitro and in vivo after administration (i.e. short half-life), poor bioavailability and potentially strong side effects requiring drug enrichment at the site of action (targeting). This review describes the use of nanoparticulate carriers, developed in our research group, as one solution to overcome the dosage forms. The performance of ODTs depends on the technology used in their manufacture. The orally disintegrating property of these tablets is attributable to the quick ingress of water into the tablet matri
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13

M. G., Mowafaq. "Development and evaluation of or dispersible tablet of Propranolol Hydrochloride by sublimation technique." Al Mustansiriyah Journal of Pharmaceutical Sciences 13, no. 2 (2013): 65–72. http://dx.doi.org/10.32947/ajps.v13i2.202.

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Propranolol Hydrochloride (PHCl) is a synthetic beta adrenergic receptor blockingagent used widely in the treatment of angina pectoris, cardiac arrhythmias and hypertension.The purpose of this study was to develop PHCl orodispersible tablet of fast disintegration inmouth with high mechanical strength to withstand handling during manufacturing and patientuse.Sublimation technique was used to prepare the orodispersible tablets of PHCl using foursubliming agents; camphor, thymol, ammonium bicarbonate and menthol by directcompression method in presence of 2.5%w/w crospovidone as superdisintegrant.
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14

Juhi, Bhadoria, and Likhariya Manoj. "A Review on Orodispersible Tablet by Using Hibiscus rosa sinesis as Natural Superdisintegrant." International Journal of Pharmaceutical Sciences and Medicine 7, no. 6 (2022): 59–69. http://dx.doi.org/10.47760/ijpsm.2022.v07i06.003.

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Oral delivery is current standard in the pharmaceutical industry wherever it is regarded as the safest, most suitable and most economical method of drug delivery. The oral cavity is an attractive site for the administration of drugs because of ease of administration. Oro-dispersible drug delivery system are Novel Drug Delivery techniques that make the tablets disintegrate in the mouth without chewing and water, and immediate release and enhanced bioavailability, with better patient compliance. Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the uni
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15

Reddy, P. Srikanth, V. Alagarsamy, P. Subhash Chandra Bose, V. Sruthi, and D. Saritha. "DESIGN AND CHARACTERIZATION OF NATEGLINIDE ORAL DISPERSIBLE TABLETS BY SOLID DISPERSION TECHNIQUE." International Journal of Research in Ayurveda and Pharmacy 13, no. 04 (2022): 72–77. http://dx.doi.org/10.7897/2277-4343.130491.

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An ideal dosage regimen in the drug therapy of any disease is the one which immediately attains the desired therapeutic concentration of drug in plasma and maintains it constant for the entire duration of treatment. The main objective of the present work is to investigate the possibility of obtaining an immediate release tablet of Nateglinide with improved dissolution using the Solid dispersion technique. Solid dispersions preparations containing different weight ratios of Nateglinide in PEG6000 (1:1, 1:3, 1:5) were prepared by the melting method and characterized for drug content, phase solub
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16

Setty, CMallikarjuna, D. V. K. Prasad, V. R. M. Gupta, and B. Sa. "Development of fast dispersible aceclofenac tablets: Effect of functionality of superdisintegrants." Indian Journal of Pharmaceutical Sciences 70, no. 2 (2008): 180. http://dx.doi.org/10.4103/0250-474x.41452.

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17

Seal, Rupam, and Dr Soundrapandian Chidambaram. "A Comprehensive Review on Progress and Challenges in Technology of Orodispersible Tablets." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 475–83. https://doi.org/10.35629/4494-0906475483.

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Numerous medications that absorb through the buccal cavity have been explored in connection to orodispersible tablet dosage forms because of their many benefits, which include stability, fast onset of action, water-free administration, precise dosing, ease of production, better bioavailability, compact packaging, and easy handling (1–5). Conventional Oro dispersible tablets have been linked to drawbacks such a lack of mechanical strength, an inclination for sugar, and the absence of an option for regulated or delayed release, if not cooked properly, an unpleasant flavor and grittiness on the t
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18

M. Aruna, Samreen, and Shaik Harun Rasheed. "Formulation and evaluation of fast disintegrating tablets of metoprolol succinate using various superdisintegrants." International Journal of Research in Pharmaceutical Sciences and Technology 1, no. 2 (2019): 79–83. http://dx.doi.org/10.33974/ijrpst.v1i2.150.

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The aim of present work is to develop a fast disintegrating solid oral dosage form of Metoprolol succinate. The concept of fast dissolving drug delivery system emerged from the desire to provide patient with more conventional means of taking their medication. Problems associated with conventional tablets can be resolved by means of fast dissolving tablets when put on tongue these tablets disintegrate and dissolve rapidly in saliva without need of drinking water. The faster the drug disintegrates in to solution, the quicker the absorption and onset of clinical effect. Preformulation results rev
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19

N. Kendre, Prakash, Akash R. Aher, Somnath K. Vibhute, Ajinkya K. Pote, Subhash V. Deshmane, and Shirish P. Jain. "EFFECT OF HYDROPHILIC POLYMER ON DESIGN EXPERT ASSISTED ORO-DISPERSIBLE STRIP (ODS) OF ISOSORBIDE MONONITRATE." Indian Drugs 59, no. 04 (2022): 60–64. http://dx.doi.org/10.53879/id.59.04.12744.

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Oral conventional formulations like tablets, capsules and liquids have many limitations. Due to this and patient incompliance, there is a need to develop new formulations with better efficiency and stability. The aim of the present study was to develop and optimize fast dissolving Oro-dispersible strips (ODS) of isosorbide mononitrate by 32 -full factorial design. HPMC E15 (X1 ) concentration and glycerin (X2 ) concentration were selected as the independent variables, whereas, in vitro disintegration time (Y1 ), percent drug release (Y2 ) and tensile strength (Y3 ) were selected as dependent v
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20

Akula, Priyanka. "Formulation and Evaluation Oral Dispersible Tablets of Vidarabine." International Journal of Pharmacy and Biological Sciences (IJPBS) 13, no. 3 (2023): 36–47. https://doi.org/10.5281/zenodo.10099936.

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<strong>Abstract</strong>In the present work, taste masking of Vidarabine was carried out by using HP-β-CD inclusion complex. These taste-masked complexes were further formulated into the Oro dispersible tablet by the direct compression method using Ac-Di-Sol and Avicel as a super disintegrant. Vidarabine is used in the treatment of AIDS. This research has described the production of a taste masked dosage form from initial determination of threshold bitterness concentration of the pure drug through to the development of a final taste masked prototype formulation. It was found that the taste ma
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21

Shashank Khailkhura, Bhavana Singh, Deepika Joshi, and Nidhi Semwal. "Orally disintegrating tablet: A review." World Journal of Biology Pharmacy and Health Sciences 11, no. 3 (2022): 018–25. http://dx.doi.org/10.30574/wjbphs.2022.11.3.0124.

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Orally dispersive tablets are solid dosage forms that dissolve in the mouth in within 10 to 30 seconds, enabling waterless ingestion. The tablet dissolves quickly due to its fast breakdown, which also causes the effects to start acting quickly. ODTs can help patients with a variety of conditions, including pediatrics, geriatrics, psychosis, dysphagia, bedridden discomfort, comatose patients, young patients with undeveloped muscular and nervous systems, patients with hand tremors, and patients who travel often. It provides high stability, precise dosage, efficient manufacture, and smaller packi
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22

Shashank, Khailkhura, Singh Bhavana, Joshi Deepika, and Semwal Nidhi. "Orally disintegrating tablet: A review." World Journal of Biology Pharmacy and Health Sciences 11, no. 3 (2022): 018–25. https://doi.org/10.5281/zenodo.7180875.

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Orally dispersive tablets are solid dosage forms that dissolve in the mouth in within 10 to 30 seconds, enabling waterless ingestion. The tablet dissolves quickly due to its fast breakdown, which also causes the effects to start acting quickly. ODTs can help patients with a variety of conditions, including pediatrics, geriatrics, psychosis, dysphagia, bedridden discomfort, comatose patients, young patients with undeveloped muscular and nervous systems, patients with hand tremors, and patients who travel often. It provides high stability, precise dosage, efficient manufacture, and smaller packi
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23

Tabeeva, G. R., A. V. Amelin, L. R. Akhmadeeva, et al. "Optimization of migraine attacks relief." Neurology, Neuropsychiatry, Psychosomatics 15, no. 2 (2023): 126–33. http://dx.doi.org/10.14412/2074-2711-2023-2-126-133.

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On December 24, 2022, in Moscow an interdisciplinary Council of Headache Experts, held under the auspice of the interregional public organization “Russian Society for the Study of Headache”, discussed the key problems of effective treatment of a migraine attack and the possibilities of a specific drug Kaporiza® (rizatriptan). Despite the development of strategies for the relief of migraine attacks and the effectiveness of triptans as first-line therapy, the choice of a specific drug in accordance with the individual clinical profile of the patient is difficult due to the existence of drugs in
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24

Prajwal, K.* Parthasarathi Kulkarni Nagendra R. Venkatesh K. Hanumanthachar Joshi. "Design And Development of Co-Processed Chitin-Lactose Monohydrate as An Excipient for Oral Dispersible Tablets." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 239–48. https://doi.org/10.5281/zenodo.14035183.

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This study describes the preparation, characterization and performance of a novel excipient for use in oral-dispersible tablets (ODT). The excipient (Cop&ndash;CLM) consists of chitin and lactose monohydrate. Specific benefits of co-processed excipients include improved flow, compressibility, disintegrating effect, and masking undesirable properties of individual excipients. The excipient with optimal physicochemical properties was obtained at a chitin: lactose monohydrate ratio of 1:2 (w/w) and produced by direct mixing. Physical properties of Co-processed chitin-lactose monohydrate (1:2 w/w)
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25

Nguyen, Phuong T. N., and Joachim Ulrich. "Fast Dispersible Cocoa Tablets: A Case Study of Freeze-Casting Applied to Foods." Chemical Engineering & Technology 37, no. 8 (2014): 1376–82. http://dx.doi.org/10.1002/ceat.201400032.

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26

Bolmal, Uday, C. K. Pandey, V. Phatarpekar, N. G. Dhople, and Rajkumar Kotha. "Comparative Evaluation of Isoniazid and Rifampicin Dispersible Tablets Prepared by Direct Compression and Sublimation Methods." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 4 (2013): 2225–39. http://dx.doi.org/10.37285/ijpsn.2013.6.4.5.

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Dispersible tablets are gaining popularity over conventional tablets due to its increased popularity for administration to pediatric and geriatric patients as it provides quick onset of action and ease of administration. An attempt had been made, to develop dispersible tablet of isoniazid and rifampicin combination by direct compression and sublimation method, to increase the bioavailability of the anti-tubercular agents as well to provide the local delivery in the case of oral tuberculosis. Formulation F1 to F8 (2% and 4% w/w of different superdisintegrants (crospovidone, pregelatinized starc
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27

S.B., Mr Jadhav, Dr Wadher S.J., and Dr Kawtikwar P.S. "Design and Evaluation of Press Coated Formulation of Aceclofenac and Comparison with Marketed Preparations." Journal of University of Shanghai for Science and Technology 23, no. 07 (2021): 387–93. http://dx.doi.org/10.51201/jusst/21/07169.

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The primary objective of the studies is to investigate whether compression coating could be used to produce tablets providing maximum drug plasma concentration 6 to 8 hours after an evening dose taken at approximately 22:00. Fast Dispersible core tablets containing Aceclofenac were prepared using super disintegrants like Ac-Di-Sol, Crospovidone, and Sodium starch glycolate through wet granulation method and evaluated for various parameters. Prepared press-coated tablets were characterized for physical parameters, drug content, lag time, in vitro drug release characteristics. Aceclofenac formul
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28

Golhen, Klervi, Michael Buettcher, Jonas Kost, Jörg Huwyler, and Marc Pfister. "Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children." Pharmaceutics 15, no. 4 (2023): 1033. http://dx.doi.org/10.3390/pharmaceutics15041033.

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A majority of therapeutics are not available as suitable dosage forms for administration to pediatric patients. The first part of this review provides an overview of clinical and technological challenges and opportunities in the development of child-friendly dosage forms such as taste masking, tablet size, flexibility of dose administration, excipient safety and acceptability. In this context, developmental pharmacology, rapid onset of action in pediatric emergency situations, regulatory and socioeconomic aspects are also reviewed and illustrated with clinical case studies. The second part of
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29

Dhar, Pintu, Himangshu Sarma, and Hemanta Kumar Sharma. "Fixed Dose Oral Dispersible Tablet of Bitter Drug Using Okra Mucilage: Formulation and Evaluation." Journal of Drug Delivery and Therapeutics 10, no. 5 (2020): 149–58. http://dx.doi.org/10.22270/jddt.v10i5.4393.

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Background: The solid oral dosage forms containing bitter drugs need improved palatability for administration. Formulation scientists have given attention to the improvement of taste masking technologies and utilised various strategies.&#x0D; Objective: The present work aimed to mask the bitter taste of Promethazine Hydrochloride by formulating Oral Dispersible Tablets using Okra mucilage as a taste-masking agent. &#x0D; Methods: The Okra mucilage was extracted from Okra by the aqueous extraction process. An emulsion solvent diffusion technique was used for masking the bitter taste of Prometha
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30

Ong, M. Y., Y. A. Yusof, M. G. Aziz, N. L. Chin, and N. A. Mohd Amin. "Characterisation of fast dispersible fruit tablets made from green and ripe mango fruit powders." Journal of Food Engineering 125 (March 2014): 17–23. http://dx.doi.org/10.1016/j.jfoodeng.2013.10.014.

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31

Abdelkader, Hamdy, Jelan A. Abdel-Aleem, Heba Salah Mousa, Marwa O. Elgendy, Adel Al Fatease, and Heba A. Abou-Taleb. "Captopril Polyvinyl Alcohol/Sodium Alginate/Gelatin-Based Oral Dispersible Films (ODFs) with Modified Release and Advanced Oral Bioavailability for the Treatment of Pediatric Hypertension." Pharmaceuticals 16, no. 9 (2023): 1323. http://dx.doi.org/10.3390/ph16091323.

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Hypertension can begin in childhood; elevated blood pressure in children is known as pediatric hypertension. Contrary to adult hypertension, there is a scarcity of commercial medications suitable for the treatment of pediatric hypertension. The aim of this study was to develop orally dispersible films (ODFs) loaded with captopril for the treatment of hypertension in children. Captopril-loaded ODFs were composed of different blends of synthetic polymers, such as polyvinyl alcohol (PVA) and polyvinyl pyrrolidone, and natural polymers, such as sodium alginate (SA) and gelatin. The ODFs were chara
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32

ALI, HUMA. "DESIGN AND OPTIMIZATION OF FAST DISPERSIBLE FORMULATIONS OF MULTI STRENGTH MELOXICAM TABLETS USING RESPONSE SURFACE METHODOLOGY." FARMACIA 67, no. 4 (2019): 709–21. http://dx.doi.org/10.31925/farmacia.2019.4.21.

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33

Jagdale, Swati Changdeo, Vaibhav Uttam Gawali, Bhanudas Shankar Kuchekar, and Aniruddha Rajaram Chabukswar. "Formulation and in vitro evaluation of taste-masked oro-dispersible dosage form of diltiazem hydrochloride." Brazilian Journal of Pharmaceutical Sciences 47, no. 4 (2011): 907–16. http://dx.doi.org/10.1590/s1984-82502011000400028.

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Diltiazem hydrochloride is a calcium channel blocker generally indicated for the treatment of angina and hypertension, and it is extensively metabolized due to the hepatic metabolism. Formulation of diltiazem hydrochloride into an oro-dispersible dosage form can provide fast relief with higher bioavailability. The bitter taste of the drug should be masked to formulate it in a palatable form. In the present work, an attempt was made to mask the taste by complexation technique, with a formulation into an oro-dispersible dosage form, using superdisintegrants Doshion P544, crospovidone (CP) and so
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34

Abou-Taleb, Heba A., Wesam W. Mustafa, Tarek Saad Makram, Lamiaa N. Abdelaty, Hesham Salem, and Hamdy Abdelkader. "Vardenafil Oral Dispersible Films (ODFs) with Advanced Dissolution, Palatability, and Bioavailability." Pharmaceutics 14, no. 3 (2022): 517. http://dx.doi.org/10.3390/pharmaceutics14030517.

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Oral, quick response, and on demand, also known as a spontaneous oral treatment for erectile dysfunction, is highly needed by both patients and physicians. Vardenafil is selective (fewer side effects) and more effective in difficult-to-treat conditions than sildenafil. This study aims at fostering the dual objectives of using biomolecules such as artificial sweetening agents to solubilize and mask the bitterness of vardenafil loaded on biodegradable polymeric materials (PVA, MC, SA, and PVP K30) to fabricate oral, fast-dissolving films (vardenafil ODFs) in the mouth without the need for water
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35

Ciurba, Adriana, Emőke Rédai, Ioana Pop, Paula Antonoaea, and Nicoleta Todoran. "Research Article. Kinetics and Mechanism of Drug Release from Loratadine Orodispersible Tablets Developed without Lactose." Acta Medica Marisiensis 63, no. 1 (2017): 23–26. http://dx.doi.org/10.1515/amma-2017-0004.

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Abstract Objective: The aim of this study is to develop lactose-free orodispersible tablets with loratadine for patients with lactose intolerance. Materials and methods: Seven compositions (F1-F7) of 10 mg loratadine were prepared in form of orally disintegrating tablets, by direct compression, using croscarmellose sodium and pre-gelatinized starch in various concentrations as superdisintegrants, diluted with microcrystalline cellulose and combined with mannitol and maltodextrin as binder agents. The tablets had been studied in terms of their pharmacotechnical characteristics, by determining:
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36

Wu, Yong Hui, Deng Guang Yu, Hua Chuan Li, and Dao Ning Feng. "Electrospun Nanofibers for Fast Dissolution of Naproxen Prepared Using a Coaxial Process with Ethanol as a Shell Fluid." Applied Mechanics and Materials 662 (October 2014): 29–32. http://dx.doi.org/10.4028/www.scientific.net/amm.662.29.

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The present paper reports a new type of medicated nanofibers loaded with naproxen, which were fabricated using a coaxial electrospinning process with only ethanol as the shell fluid. Field emission scanning electron microscopic observations clearly showed that high quality linear nanofibers with smooth surface and an average diameter of 270 ± 60 nm were generated under a shell-to-core fluid rate ratio of 0.2. X-ray diffraction patterns suggested that the drug was distributed homogeneously in the polymer matrix. In vitro dissolution tests demonstrated that the nanofibers could release the entir
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37

Naji, Ghada Hamid, Worood Hameed Al-Zheery, and Noor Yousif Fareed. "DESIGN AND IN VITRO EVALUATION OF ACRIVASTINE AS ORODISPERSIBLE TABLET USING DIRECT COMPRESSION METHOD." Wiadomości Lekarskie 76, no. 1 (2023): 170–74. http://dx.doi.org/10.36740/wlek202301123.

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The aim: This study aimed to develop mouth-dissolving tablets of Acrivastine, an antihistamine medication, in order to increase its oral bioavailability. Materials and methods: Different super disintegrants, such as crospovidone, croscarmellose sodium, and sodium starch glycolate, were used to make Acrivastine oral dispersible tablets (ODTs). These super disintegrants were utilized in various concentrations. The formulation (F3) with 6% w/w crospovidone had a fast disintegration time (less than 30 seconds) and practically total drug release within 10 minutes. All of the formulations were made
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38

Jha, Devanand, Gagan Kumar Utwaliya, Kumari Sindhu, et al. "The Design and Optimization of Fast-dissolving Oral Drug Delivery System (ODDS) of Valproic Acid (VLA) an Anti-epileptic Category Drug." Advances in Research 25, no. 2 (2024): 152–66. http://dx.doi.org/10.9734/air/2024/v25i21042.

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Objective: Develop and optimize a fast-dissolving oral drug delivery system (ODDS) for Valproic acid (VLA), an anti-epileptic drug, using Design of Experiments (DoE). Methodology: DoE, a powerful tool for optimizing formulations, was employed to investigate the impact of various factors on the dissolution rate of VLA ODDS. Key factors studied included superdisintegrants (sodium starch glycolate, crospovidone), diluents (lactose, microcrystalline cellulose), and lubricants (magnesium stearate). A Box-Behnken design was used to create experimental runs, and the dissolution rate at 30 minutes was
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BHATT, Shailendra, Dabashis ROY, Manish KUMAR, Renu SAHARAN, Anuj MALIK, and Vipin SAINI. "Development and Validation of In Vitro Discriminatory Dissolution Testing Method for Fast Dispersible Tablets of BCS Class II Drug." Turkish Journal of Pharmaceutical Sciences 17, no. 1 (2020): 74–80. http://dx.doi.org/10.4274/tjps.galenos.2018.90582.

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40

Iqbal, Sonia, Hanasul Hanan, Afshan Maqbool, and Nasra Munawar. "A review on orodispersible drug delivery system." Journal of Contemporary Pharmacy 7, no. 1 (2023): 24–31. http://dx.doi.org/10.56770/jcp2023714.

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The future of drug delivery holds great promise for orally dispersible dose formulations, which make application simple since no water requirement as compared to conventional solid dosage forms which requires significant volumes of fluids for administration. The objective for development of ODF provides a substitute for pills, syrups, and tablets in treating vomiting as well as nausea, particularly in children. On the basis of transdermal patch delivery system, a novel oral films drug delivery has been introduced. Fast dissolving films disintegrates quickly when come in contact with salivary s
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Iqbal, Sonia, Hanasul Hanan, Afshan Maqbool, and Nasra Munawar. "A review on orodispersible drug delivery system." Journal of Contemporary Pharmacy 7, no. 1 (2023): 24–31. http://dx.doi.org/10.56770/jcp.2023714.

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The future of drug delivery holds great promise for orally dispersible dose formulations, which make application simple since no water requirement as compared to conventional solid dosage forms which requires significant volumes of fluids for administration. The objective for development of ODF provides a substitute for pills, syrups, and tablets in treating vomiting as well as nausea, particularly in children. On the basis of transdermal patch delivery system, a novel oral films drug delivery has been introduced. Fast dissolving films disintegrates quickly when come in contact with salivary s
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42

Ahmed, Jwan, Dina Boya, and Hunar Kamal. "Formulation of a fast-dissolving oral film using gelatin and sodium carboxymethyl cellulose." Zanco Journal of Medical Sciences 24, no. 3 (2020): 338–46. http://dx.doi.org/10.15218/zjms.2020.040.

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Background and objective: Orally disintegrating film is a solid dosage form made as an alternative for tablets for pediatric and geriatric patients who have difficulty in swallowing. These formulations are designed to dissolve in the mouth rapidly upon contact with saliva. This study aimed to prepare a thin oro-dispersible film base that can withstand handling in which a drug can be incorporated to provide a new dosage form. Methods: The solvent casting method was used to prepare the films, in which the ingredients were mixed, dissolved, and cast in a Petri dish. Then, they were left to dry in
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43

Vaishali, Mukhmale* Aijaz Sheikh Kailash Biyani. "Formulation and Evaluation of Mouth Dissolving Film (MDFs) Containing Active Pharmaceutical Ingredient (API)." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2121–26. https://doi.org/10.5281/zenodo.15397518.

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As an empiric therapy for nausea and vomiting, ondansetron is among the most often prescribed drugs.&nbsp; The antiemetic properties of ondansetron make it a useful medicine for treating nausea and vomiting caused by a wide range of conditions.&nbsp; Ondansetron is commonly used to reduce nausea and vomiting caused by chemotherapy and radiation, and it is also used off-label to prevent nausea and vomiting during pregnancy. It is also used to prevent nausea and vomiting after surgery.&nbsp; Having said that, it won't help with nausea caused by motion sickness.&nbsp;&nbsp; Eligible patient demog
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Khan, Amjad, Zafar Iqbal, Ibrahim Khadra, et al. "Simultaneous determination of domperidone and Itopride in pharmaceuticals and human plasma using RP-HPLC/UV detection: Method development, validation and application of the method in in-vivo evaluation of fast dispersible tablets." Journal of Pharmaceutical and Biomedical Analysis 121 (March 2016): 6–12. http://dx.doi.org/10.1016/j.jpba.2015.12.036.

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45

Ngadaya, Esther, Alexander Manu, Mary Mmweteni, et al. "Management of possible serious bacterial infections in young infants where referral is not possible in the context of existing health system structure in Mbeya, Tanzania: Experience and lessons from the end line assessment." PLOS ONE 19, no. 12 (2024): e0310259. https://doi.org/10.1371/journal.pone.0310259.

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Severe bacterial infections (SBIs) are a leading cause of neonatal deaths in low- and middle-income countries. World Health Organization’s (WHO’s) guideline for outpatient management of danger signs indicating possible serious bacterial infections (PSBI) when referral is not possible was adopted by three pilot district councils in Mbeya Region, in Tanzania (Busekelo, Kyela and Mbarali Districts) in 2018 (the PSBI project). This study documented changes in practice during the PSBI project, and lessons learned. A cross-sectional study was conducted using both qualitative and quantitative data co
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46

Paka Bhavana and M Sunitha Reddy. "A review on co-processed excipients used in direct compression of tablet dosage form." GSC Biological and Pharmaceutical Sciences 23, no. 1 (2023): 212–19. http://dx.doi.org/10.30574/gscbps.2023.23.1.0100.

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Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale. The following study aimed to characterize a range of co-processed excipients that may prove suitable for dispersible tablet formulations prepared by direct compression. The dosage form that is used the most is tablets. Their accessibility, simplicity of administration, consistency, and affordability are advantages. Direct compression is the most straightforward method for making tablets, despite the fact that it comes with several challenges, in
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47

Paka, Bhavana, and Sunitha Reddy M. "A review on co-processed excipients used in direct compression of tablet dosage form." GSC Biological and Pharmaceutical Sciences 23, no. 1 (2023): 212–19. https://doi.org/10.5281/zenodo.7925418.

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Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale. The following study aimed to characterize a range of co-processed excipients that may prove suitable for dispersible tablet formulations prepared by direct compression. The dosage form that is used the most is tablets. Their accessibility, simplicity of administration, consistency, and affordability are advantages. Direct compression is the most straightforward method for making tablets, despite the fact that it comes with several challenges, in
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48

Disha, Wankhede* Damini Mundhare. "Formulation And Evaluation Of Oral Dispersible Tablet Containing Giloy." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 342–50. https://doi.org/10.5281/zenodo.14045993.

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Tablets, the most common drug delivery system, provide the opportunity to incorporate new technologies to produce more dosage forms. Orally dispersible drug delivery systems are widely used to improve bioavailability and patient compliance. Orally dispersible tablets (ODT) have been developed for children, the elderly, bedridden patients, and patients without access to water. In fact, swallowing problems develop in young people due to weakening of muscles and nerves. In some cases, such as cold, cough and inability to drink, tablets may be difficult or uncomfortable to swallow. ODT creates a s
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Maurya, Arpana, Dilip kumar Gupta, and Munendra Mohan Varshaney. "FORMULATE AND EVALUATE THE ORAL DISPERSIBLE TABLET OF ANTIDIABETIC DRUG TENELIGLIPTIN." INTERNATIONAL RESEARCH JOURNAL OF PHARMACY 12, no. 10 (2021): 7–12. http://dx.doi.org/10.7897/2230-8407.1210165.

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Orodispersible tablets (ODTs) are novel drug delivery systems that have the potential to significantly affect conventional dosage forms in terms of patient compliance, convenience, bioavailability, and time to action. Despite the fact that significant research has gone into developing ODT formulations and technologies, in order to produce newer, more expense technologies and better items, more research is needed in these major destinations. Because of the availability of new technologies, as well as good market acceptance and patient compliance, the potential of dosage forms is attractive. Pha
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Sundeep, Kaur Manjal, Bhatia Rohit, and K. Rawal Ravindra. "Recent Advancements in Technologies Involved in Formulation Development." Trends in Pharmaceuticals and Nanotechnology 1, no. 2 (2019): 2019. https://doi.org/10.5281/zenodo.2656917.

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<em>Pharmaceutical sciences are comprised of a wide number of areas including drug discovery, formulation development, testing, safety and miscellaneous regulatory affairs. In the last four decades, the literature in pharmaceutical drug development has been increased in a surprising manner. There is a continuous development of variety of formulations which are designed according to the patient compliance, physical compatibility, and therapeutic efficacy and to overcome the shortcomings or adverse effects of the pre-existing formulations. In the present study, authors have summarized different
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