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Journal articles on the topic 'Fast Dissolving Films (FDFs)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Iram, Rimsha, Iqra Akram, Bushra Anwaar, and Anum Farooq. "Fabrication and characterization of fast dissolving films of H2-receptor antagonist." Journal of Contemporary Pharmacy 3, no. 1 (2019): 7–11. http://dx.doi.org/10.56770/jcp2019312.

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Objective: The aim of the present study was to develop a fast dissolving film (FDF) of taste masked inclusioncomplex of Famotidine (FMT) using film forming polymer. Method: FDFs were prepared by solvent castingmethod. The developed FDFs were characterized for film thickness, disintegration time, flexibility, dissolutionstudy. The developed FDFs of FMT were transparent, elegant, smooth and homogenous. Results: Physicochemicalcharacterization of FDFs showed no interaction between the drug and film forming polymer. The drug content wasfound in the range of 96.05 to 102% and disintegration time wa

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SK., Shahanaj* Sasikanth Kothamasu Manohar Babu S. "FORMULATION DEVELOPMENT AND EVALUATION OF FAST RELEASE FILMS OF GALANTAMINE." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2164–69. https://doi.org/10.5281/zenodo.837294.

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In the present work efforts have been made to prepare the fast dissolving films of Galantamine using water soluble semi synthetic polymers such as HPMC 3cps, Na CMC and KollicoatIR using plasticizer by means of sodium starch glycolate, super-disintegrants by using the solvent casting method. By comparing with the marketed tablet, the FDFs formulated by means of using superdisintegrant showed fast release for quicker onset of action within minutes. The prepared films were evaluated for physico-chemical properties and invitro release kinetics. The selected formulations produced clear, uniform, f

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3

Ehtezazi, Touraj, Marwan Algellay, and Alison Hardy. "Next Steps in 3D Printing of Fast Dissolving Oral Films for Commercial Production." Recent Patents on Drug Delivery & Formulation 14, no. 1 (2020): 5–20. http://dx.doi.org/10.2174/1872211314666191230115851.

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3D printing technique has been utilised to develop novel and complex drug delivery systems that are almost impossible to produce by employing conventional formulation techniques. For example, this technique may be employed to produce tablets or Fast Dissolving oral Films (FDFs) with multilayers of active ingredients, which are personalised to patient’s needs. In this article, we compared the production of FDFs by 3D printing to conventional methods such as solvent casting. Then, we evaluated the need for novel methods of producing fast dissolving oral films, and why 3D printing may be able to

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Dingalwar, Achal, Anil Pethe, Tanmay Kopare, and Umesh Telrandhe. "An Overview of the Components, Techniques, and Innovation Used for Fast-Dissolving Films." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1853–62. http://dx.doi.org/10.25258/ijddt.14.3.84.

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Fast-dissolving films (FDFs) stand as a cornerstone in modern pharmaceutical innovation, heralded for their unrivaled convenience, patient adherence, and the swift onset of action. Within the realm of this paper lies a meticulous exploration of FDFs, delving deep into their intricate formulation intricacies, manufacturing methodologies, and diverse therapeutic applications. The formulation journey traverses the meticulous selection of film-forming polymers, plasticizers, taste-masking agents, and active pharmaceutical ingredients (APIs), each element meticulously calibrated to achieve optimal

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Algellay, Marwan, Matthew Roberts, Lucy Bosworth, Satyajit D. Sarker, Amos A. Fatokun, and Touraj Ehtezazi. "The Use of Micro-Ribbons and Micro-Fibres in the Formulation of 3D Printed Fast Dissolving Oral Films." Pharmaceuticals 16, no. 1 (2023): 79. http://dx.doi.org/10.3390/ph16010079.

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Three-dimensional printing (3DP) allows production of novel fast dissolving oral films (FDFs). However, mechanical properties of the films may not be desirable when certain excipients are used. This work investigated whether adding chitosan micro-ribbons or cellulose microfibres will achieve desired FDFs by fused deposition modelling 3DP. Filaments containing polyvinyl alcohol (PVA) and paracetamol as model drug were manufactured at 170 °C. At 130 °C, filaments containing polyvinylpyrrolidone (PVP) and paracetamol were also created. FDFs were printed with plain or mesh patterns at temperatures

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Al-Kubati, Sana Saleh, Muna Abdo Ahmed, and Nasr A. Emad. "Palatable Levocetirizine Dihydrochloride Solid Dispersed Fast-Dissolving Films: Formulation and In Vitro and In Vivo Characterization." Scientific World Journal 2022 (November 28, 2022): 1–9. http://dx.doi.org/10.1155/2022/1552602.

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One of the most important issues for bitter-tasting drugs such as levocetirizine dihydrochloride (LCD) is the production of palatable dosage forms. LCD also has a delayed onset of action following oral administration. In this study, solid dispersed fast-dissolving films (FDFs) of LCD using the solvent casting method for oral application were prepared and evaluated. The FDF is composed of HPMC as the film forming polymer and different types of superdisintegrants (sodium starch glycolate, croscarmellose sodium, or crospovidone). FDF containing crospovidone showed the highest percentage release o

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Yadav, Chandrajeet Kumar, Manish Karn, Pinki Yadav, and Roshan Mehta. "Formulation, Optimization and In-vitro Evaluation of Fast Dissolving Oral films of Metoclopramide Hydrochloride by Solvent Casting method." International Journal of PharmTech Research 13, no. 3 (2020): 229–41. http://dx.doi.org/10.20902/ijptr.2019.130314.

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The Present study aimed to prepare fast dissolving oral films (FDFs) of metoclopramide hydrochloride, because of its application in emesis condition where fast onset of action and avoidance of water is highly desirable. Moreover, this dosage form is highly useful in pediatrics, geriatrics and unconscious patients. FDFs were prepared by solvent casting technique with film forming polymers HPMC, PVA & Sodium alginate in varying concentrations with excipients like SLS as surfactant, Glycerol as plasticizer, citric acid as saliva stimulating agent, Sodium Saccharin as sweetening agent. The fil

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Ashraf, Ibrahim, Pierre A. Hanna, Shadeed Gad, Fathy I. Abd-Allah, and Khalid M. El-Say. "Enhancing Pharmacokinetics and Pharmacodynamics of Rosuvastatin Calcium through the Development and Optimization of Fast-Dissolving Films." Pharmaceutics 15, no. 11 (2023): 2640. http://dx.doi.org/10.3390/pharmaceutics15112640.

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Rosuvastatin (RSV) is a widely used cholesterol-lowering medication, but its limited bioavailability due to its susceptibility to stomach pH and extensive first-pass metabolism poses a significant challenge. A fast-dissolving film (FDF) formulation of RSV was developed, characterized, and compared to the conventional marketed tablet to address this issue. The formulation process involved optimizing the thickness, disintegration time, and folding durability. All formulations were assessed for in vitro disintegration, thickness, folding endurance, in vitro dissolution, weight, and content unifor

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V, Attal, and Daniel K. "Preparation of Mouth Dissolving Sublingual Film of Fixed Dose Combination of Hydrochlorothiazide and Losartan Potassium and Statistical Optimization of Film." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1344–52. http://dx.doi.org/10.25258/ijddt.14.3.13.

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Fast-dissolving films (FDFs) are innovative dosage forms offering advantages such as improved patient compliance, rapid onset of action, precise dosing, and favorable taste. Particularly beneficial for patients unable to swallow or require immediate drug absorption, FDFs dissolve rapidly in the mouth, releasing medication directly into the oral cavity. The sublingual application enhances drug delivery due to the high permeability of the sublingual mucosa, bypassing hepatic first-pass metabolism. This route is advantageous for drugs like losartan potassium (LP) and hydrochlorothiazide (HCZ), wh

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Palwinder, Singh* and Rajeev Garg. "FAST DISSOLVING ORAL FILMS: A NOVEL TREND IN DOSAGE FORM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 4571–78. https://doi.org/10.5281/zenodo.1256824.

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Oral routes are most commonly preferred route for drug delivery. Commonly used oral dosage forms are tablet and capsules. But many patients such as geriatric, paediatric and dysphasic patients find difficulty in swallowing conventional tablet and capsule. To overcome the problems related to swallowing, Fast dissolving Tablets (FDTs) were designed in early 19th century and hence further advancement has led to development of Fast Dissolving Oral Films (FDOFs). Many pharmaceutical groups are focusing their research on rapid dissolving technology. FDOFs technology is gaining much attention. This t

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Siddhesh, Gawari* S. R. Ghodake. "Formulation and Evaluation of Fast Dissolving Film of Lisinopril." International Journal of Scientific Research and Technology 2, no. 4 (2025): 664–89. https://doi.org/10.5281/zenodo.15304422.

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"An ultra-thin film containing an active ingredient that dissolves or disintegrates in the saliva at aremarkably fast rate, within few seconds without the aid of water or chewing," is the definition ofa fast-dissolving oral film (FDOF). The most up-to-date oral solid dosage form is fast-dissolving oral films (FDOFs), which provide more comfort and flexibility. It improves the absorption of active pharmaceutical ingredients (APIs) by dissolving them in saliva and allowing them to be swallowed without chewing or water. The oral mucosa is four to a thousand times more permeable than the epidermis

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Bhattarai, Mukem, and Amit Kumar Gupta. "Fast Dissolving Oral Films: A Novel Trend to Oral Drug Delivery System." Sunsari Technical College Journal 2, no. 1 (2016): 58–68. http://dx.doi.org/10.3126/stcj.v2i1.14802.

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Oral routes are most commonly preferred route for delivering drug. Most common oral dosage forms are tablet and capsules. But many patients such as geriatric, pediatric and dysphasic patients find difficult to swallow conventional tablet and capsule. To overcome various problems related to swallowing, Fast dissolving Tablets (FDTs) were designed in early 19th century and hence further advancement has led to development of Fast Dissolving Oral Films (FDOFs). In the recent years, many of the pharmaceutical groups are focusing their research on rapid dissolving technology. Amongst the plethora of

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Alwan, Zahraa Salim, and Nawal Ayash Rajab. "Preparation and Characterization of Febuxostat Nanosuspension as Fast Dissolving Oral Film." Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ) 6, no. 2 (2024): 171–77. http://dx.doi.org/10.54133/ajms.v6i2.873.

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Background: Quickly dissolved oral films are a widely accepted method of delivering drugs and help patients adhere to treatment regimens. Nanosuspensions (NS) are colloidal dispersions of drug particles with a submicron size, and their large surface area enhances the solubility and dissolution of low-water-soluble drugs. Febuxostat (FXT) is a non-purine xanthine oxidase inhibitor with a low dissolution rate that limits its absorption. Objective: To develop fast-dissolving oral films (FDOFs) containing FXT NS and convert NS into solid dosage forms to ease administration and accelerate drug rele

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Mishra, Soumya, Nidhi Bais, and Sachin Kumar Jain. "Formulation and Evaluation of Mouth Dissolving Film of Imipramine HCL." Journal of Biomedical and Pharmaceutical Research 12, no. 4 (2023): 22–29. http://dx.doi.org/10.32553/jbpr.v12i4.1015.

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The main objective of the present study outlines a systematic approach for Design and Evaluation of Fast Dissolving Oral Films of Imipramine HCl to enhance the therapeutic efficacy and provide rapid onset of action in patients suffering from depression Because of patient may have trouble in swallowing a tablet or capsules. Mouth dissolving film is the most advanced oral solid dosage form due to its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. This dosage for

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Sk., Althaf B. Valli Manalan P. Prachet N. Rama Rao. "FORMULATION DEVELOPNENT AND EVALUATION OF NADOLOL ORAL FAST DISSOLVING FILMS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 09 (2019): 16098–107. https://doi.org/10.5281/zenodo.3406341.

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<em>The main goal in the development of any drug formulation is to achieve the complete drug release within the time or prior to it. Most of the drug delivery systems are successful because of their safety, most convenient and most economical drug delivery with highest patient compliance. In this a very thin oral strap consisting of drug disintegrates very fastly in the mouth and releases the drug into circulation the oral cavity therefore absorbed into the systemic.</em> <em>The aim of the present study is to formulate the oral fast dissolving films of Nadolol using HPMC K<sub>4</sub>M 

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16

Pawar, Harshal Ashok, and Mohd Saif Mohd Akram Momin. "Solubility Enhancement of Glipizide and Development of its Fast-dissolving Oral Film." Current Drug Therapy 16, no. 5 (2021): 423–29. http://dx.doi.org/10.2174/1574885516666211129142107.

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Background: Difficulty in swallowing tablet dosage form is common among all ages people, especially old and pediatrics. Fast dissolving oral films (FDOFs) may represent an innovative dosage type that settles the issue of gulping and supply fast onset of action. Objective: The objective of the present investigation was to increase the solubility of poorly soluble Glipizide (BCS Class II) by solid dispersion technique and develop its FDOFs. Methods: A solvent evaporation process was used to make a solid dispersion of the Glipizide. The saturation solubility of glipizide and its solid dispersion

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Preetesh, P. Sawant1 Rajashree Gude*2 Akshata J. Naik3 Saba Jamadar4. "Fabrication And Characterization of 3D Printed Fast Dissolving Oral Films of Ivabradine Hydrochloride." International Journal of Pharmacy and Biological Sciences (IJPBS) 15, no. 1 (2025): 6–17. https://doi.org/10.5281/zenodo.15035091.

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AbstractThree-dimensional (3D) printing technology is gaining significance due to its wide applications, rapid prototyping and customization. Fast-Dissolving Oral Films (FDOFs) provide an alternative approach to increase consumer acceptance by advantage of rapid disintegration and dissolution and administration without water. Combination of fused deposition modelling with preparation of the FDOFs seems to be extra advantageous in terms of pharmaceutical parameters. Ivabradine Hydrochloride was selected for formulating FDOF which is an Anti-Anginal drug. The aim of the present study is to fabri

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Narwariya, Shailendra Singh, Manju Gupta, Alagusundaram M, Sai Sri Harsha G, China Babu Dara, and Alok Kumar Soni. "Development and description of mouth-dissolving drug delivery system." Future Journal of Pharmaceuticals and Health Sciences 4, no. 2 (2024): 127–34. http://dx.doi.org/10.26452/fjphs.v4i2.622.

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Fast-dissolving oral films (FDOFs) offer superior comfort and flexibility as they dissolve in the oral cavity upon contact with saliva within minutes, enhancing the efficacy of active pharmaceutical ingredients (APIs) without the need for chewing or drinking. Epilepsy, a neurological disorder, requires prompt seizure management. Lamotrigine (LMG), a novel antiepileptic drug, treats various types of seizures. Complexing LMG with ?-cyclodextrins enhances solubility and masks its bitter taste. Researchers developed and evaluated fast-dissolving lamotrigine films to improve palatability and bioava

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Narwariya, Shailendra Singh. "Development and description of mouth-dissolving drug delivery system." Development and description of mouth-dissolving drug delivery system 4, no. 2 (2024): 127–34. https://doi.org/10.5281/zenodo.14651850.

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Fast-dissolving oral films (FDOFs) offer superior comfort and flexibility as they dissolve in the oral cavity upon contact with saliva within minutes, enhancing the efficacy of active pharmaceutical ingredients (APIs) without the need for chewing or drinking. Epilepsy, a neurological disorder, requires prompt seizure management. Lamotrigine (LMG), a novel antiepileptic drug, treats various types of seizures. Complexing LMG with ?-cyclodextrins enhances solubility and masks its bitter taste. Researchers developed and evaluated fast-dissolving lamotrigine films to improve palatability and bioava

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J. Naga Sowjanya and P. Raja Rao. "QBD driven optimized approach for formulation of ginkgo biloba extract -fast dissolving oral films (FDOF’S)." World Journal of Biology Pharmacy and Health Sciences 19, no. 2 (2024): 351–63. http://dx.doi.org/10.30574/wjbphs.2024.19.2.0538.

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As Alzheimer's disease (AD) advances, cholinergic dysfunction, β-amyloid plaques and neurofibrillary tangle development, oxidative damage, and neuroinflammation occur, making the major addressal setting the health care environment. Though less successful than a synthetic method, the therapy of AD has focused on cholinergic dysfunction, inflammation, and oxidative damage. Neurodegenerative diseases are treated commercially with gingko biloba extract. FDOFs are therefore effective in changing and enhancing the bioavailability of nutraceuticals. FDOFs of Gingko biloba extract were formulated usin

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Cheng, En, Zhanhui Geng, Lubing Xiang, Xiaoying Zhao, Aimin Xiang, and Huafeng Tian. "Development of Vitamin C-Loaded Electrospun Nanofibers of Mixture of Polysaccharides of Pullulan/Xanthan Gum for Fast Dissolving Oral Film Applications." Materials 17, no. 4 (2024): 861. http://dx.doi.org/10.3390/ma17040861.

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In this study, polysaccharide-based nanofibrous fast dissolving oral films (FDOFs) were developed using pullulan (PUL) and xanthan gum (XG) via electrospinning. The edible, continuous, and bead-free nanofibers with average diameters ranging from 181.17 nm to 260.84 nm were prepared. The morphological, thermal, mechanical, and water-soluble properties of the nanofibrous FDOFs were characterized. For prospective future applications of the developed PUL/XG FDOFs, a model nutrient of vitamin C (VC) was encapsulated into the FDOFs. The success of VC encapsulation was confirmed by Fourier transform

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Wadetwar, Rita N., and Tejaswini Charde. "DESIGN, DEVELOPMENT, AND CHARACTERIZATION OF OROMUCOSAL WAFER OF TRAMADOL HYDROCHLORIDE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 116. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.25709.

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Objective: The objective of the present work was the preparation of fast-dissolving film of tramadol HCl (TMH) using water-soluble polymer, to achieve faster onset of action, to improve patient compliance, ease of dosing, and bypass the first-pass metabolism. Methods: TMH oromucosal wafers were prepared using pullulan as natural, biodegradable polymer, and propylene glycol as plasticizer by solvent casting method. Formulation batches were prepared using 32 full-factorial designs. The prepared TMH oromucosal wafers were characterized for morphology, uniformity of weight, drug content, folding e

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Abbas, Ishraq K., Nawal A. Rajab, and Ahmed A. Hussein. "Formulation and In-Vitro Evaluation of Darifenacin Hydrobromide as Buccal Films." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 28, no. 2 (2019): 83–94. http://dx.doi.org/10.31351/vol28iss2pp83-94.

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Darifenacin hydrobromide (DH) is the more recent uroselective M3 receptor antagonist for treating uncomplicated overactive bladder (OAB). This study was aimed to formulate DH as fast dissolving buccal films (FDBFs) using a solvent casting method to enhance patient’s compliance. Films were prepared by using polyvinyl alcohol (PVA) as a film forming polymer. Different types and concentrations of superdisintegrants (croscarmellose sodium, sodium starch glycolate, indion 414) were used to select the best formula by studying the physicochemical properties of the films, disintegration time (DT

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Naga Sowjanya, J. "In Vitro And In Vivo Approaches to Evaluate Uncaria Tomentosa Bark Extract Loaded FDOFS on Osteoarthritis Models." Clinical Medical Reviews and Reports 5, no. 04 (2023): 01–10. https://doi.org/10.31579/2690-8794/156.

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Osteoarthritis is one the leading health concerns worldwide affecting two third million with no proper treatment ensured to restore the normal function and completely relieving the joint pain. Oral fast dissolving films have promising action and targeted delivery with high drug loading capacity. The present investigation involves the study the invitro and in vivo activity of developed Oral fast dissolving films of U. tomentosa bark extract with optimized F5 and F13 formulations. For invitro evaluation a three-dimensional OA model was prepared with first passage chondrocytes grown on trypsin ED

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Surajkumar, Bhaskarao Rathod, Prakashrao Tekade Nilesh, Nitin Shridharao Bhajipale Dr., and Dhirendra Babji Sanghai Dr. "Rospective designing and types of buccal drug delivery system: The Review." GSC Biological and Pharmaceutical Sciences 12, no. 3 (2020): 174–79. https://doi.org/10.5281/zenodo.4266035.

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Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms for treatment of many diseases. The mucosa of the buccal cavity is the most easily accessible transmucosal site. This fast dissolving drug delivery system (FDDS) is suited for the drugs which undergo high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to mouth plasma peak levels, which in turn minimize adverse/side effects and also make it cost effective This article aims to review the re

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Dr.A.Yasodha. "FORMULATION AND DEVELOPMENT OF ORAL DISSOLVING FILMS OF BUMETANIDE." iajps,csk publications 03, no. 11 (2016): 1424–36. https://doi.org/10.5281/zenodo.208205.

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Objective: Formulation and Development of oral dissolving Films of Bumetanide. Materials and methods: BUMETANIDE, HPMC E-50, HPMC E-5, HPMC E-3, PE, 4000 (Flakes) and Aspartame. Citric Acid could be formulated with low viscosity film formers viz. HPMC E50 in combination with HPMC E5, E15. Bumetanide could be successfully incorporated in FDFs with of the above polymers and polyethylene glycol 4000 is used as a plasticizer. PEG 4000 itself has a solubulizing affect and result in faster dissolution. Hence, there is no need of superdisintegrants. Use of low viscosity grade HPMC polymers resulted i

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Teaima, Mahmoud, Mohamed Yasser, Nehal Elfar, Kamel Shoueir, Mohamed El-Nabarawi, and Doaa Helal. "Construction of sublingual trilaminated Eszopiclone fast dissolving film for the treatment of Insomnia: Formulation, characterization and In vivo clinical comparative pharmacokinetic study in healthy human subjects." PLOS ONE 17, no. 6 (2022): e0266019. http://dx.doi.org/10.1371/journal.pone.0266019.

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Background Disturbed sleep can cause to m health problems such as cognitive impairment, depressed mood, and negative effects on cardiovascular, endocrine, and immune function. This study formulates and optimizes Eszopiclone trilaminate fast dissolving film. Methods Prepared Eszopiclone trilaminate fast dissolving film (Eszopiclone TFDF) was characterized by disintegration time, drug release, tensile strength (TS), percentage elongation (EB%), folding endurance, taste masking test, and in vitro dissolution test. The selected formulas were F2 (0.5% xanthan gum, 10% propylene glycol), F4 (3% sodi

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Chaturvedi, Ankita, Pranati Srivastava, Sunita Yadav, Mayank Bansal, Garima Garg, and Pramod Kumar Sharma. "Fast Dissolving Films: A Review." Current Drug Delivery 8, no. 4 (2011): 373–80. http://dx.doi.org/10.2174/156720111795768022.

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Muthukumar, Sundaraganapathy R, Sankar C, Sundaramoorthy C, and Yuvaraja K R. "Stability studies of hydralazine hydrochloride orodispersible formulations." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 75–86. http://dx.doi.org/10.26452/ijrps.v11i1.1788.

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Solid dosage forms also have a impervious difficulties in patients especially for geriatric and paediatric patients.Dysphagia is common among all age groups. Orodispersible formulations (Fast dissolving tablets & Fast dissolving oral thin films) constitute an inventive dosage form that overcome the problems swallowing and provides speedy onset of action. The objective of present study was to formulate orodispersible formulations of Hydralazine HCL by different methods (Direct compression method, Sublimation method and solvent casting method). Based on physiochemical evaluations F9 (Direct

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Gupta, Prajjwal, Chaya Rani, Kanishka Chauhan, and Harsh Sisodia. "A Short Review on “A Novel Approach in Fast Dissolving Film & their Evaluation Studies”." International Journal of Current Research and Review 14, no. 18 (2022): 29–34. http://dx.doi.org/10.31782/ijcrr.2022.141806.

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In the case of chronic illnesses, fast-dissolving drug delivery systems were developed as an oral medication administration alternative to traditional dose forms. For masking the taste of unpleasant drugs and enhancing patient compliance, fast-dissolving films are now recommended over traditional tablets and capsules. Fast dissolving films consist of a very thin oral strip that dissolves in less than one minute when placed on the tongue. Customers have responded positively to dissolvable oral thin films in the form of breath strips, which have been on the market for a few years and are used to

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Cilurzo, Francesco, Irma E. Cupone, Paola Minghetti, Francesca Selmin, and Luisa Montanari. "Fast dissolving films made of maltodextrins." European Journal of Pharmaceutics and Biopharmaceutics 70, no. 3 (2008): 895–900. http://dx.doi.org/10.1016/j.ejpb.2008.06.032.

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Sanam, Poonam A., Nayana S. Baste, and Sanjay B. Patil. "Advancements in Fast Dissolving Oral Films." Advances in Pharmacology and Pharmacy 13, no. 3 (2025): 287–96. https://doi.org/10.13189/app.2025.130301.

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Ashwini, B. Pote* Snehal B. Zarad Ashok Dalibe. "A Review On : Fast Dissolving Oral Thin Film." International Journal in Pharmaceutical Sciences 1, no. 12 (2023): 474–81. https://doi.org/10.5281/zenodo.10401691.

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Oral Fast-dissolving drug delivery systems have been developed as an alternative to conventional dosage form as an oral means of drug delivery in case of chronic conditions. Now a day's fast dissolving films are preferred over conventional tablets and capsules for masking the taste of bitter drugs to increase the patient compliance. Fast dissolving films consist of a very thin oral strip which dissolves in less than one minute when placed on the tongue. Dissolvable oral thin films are in the market since past few years in the form of breath strips and are widely accepted by consumers for deliv

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Bir, Pawan Kumar* and Sandeep Kumar. "FAST DISSOLVING FILMS: AN INNOVATIVE APPROACH TO ORAL DRUG DELIVERY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 3714–19. https://doi.org/10.5281/zenodo.1245921.

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<em>Fast dissolving films is a novel approach that are rapidly gaining interest for the patients having difficulties in swallowing or chewing of solid dosage forms such as tablets or capsules. Fast-dissolving drug-delivery systems were first developed in the late 1970s for pediatric and geriatric patients who experience difficulties in swallowing traditional oral solid dosage forms. These films may deliver the drug in a systemically manner through sublingual or buccal route and also used for local action. The present review reflects the information regarding the ideal characteristics, method o

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Zeenath, Ruhy. "Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL." International Journal of Trend in Scientific Research and Development 4, no. 1 (2019): 847–52. https://doi.org/10.5281/zenodo.3609734.

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Metaclopromide HCl is an Anti emetic used to treat nausea, vomiting and to increase gastric motility. The present work aimed at preparing oral fast dissolving films of Metaclopromide HCl with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral fast dissolving films of Metaclopromide HCl were prepared using HPMC E5, E15 polymers as film forming agents and polyethylene glycol 400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug

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Pamula, Reddy Bhavanam*. "FORMULATION AND DEVELOPMENT OF ZOLPIDEM TARTRATE FAST DISSOLVING FILMS BY USING SODIUM CMC." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 2735–40. https://doi.org/10.5281/zenodo.886323.

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Drug is used for the treatment of insomnia and some brain disorders. The purpose of the present work is to formulate and enhance the drug release of zolpidem tartrate by the incorporation of suitable polymer in the oral dissolving films (OTF) for use in specific populations viz. geriatrics and patients experiencing difficulty in swallowing. The oral dissolving films loaded with zolpidem tartrate were prepared by solvent evaporation method using sodium CMC by adding suitable plasticizer glycerin. The prepared oral dissolving films were evaluated for drug content, weight variation, thickness, pH

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Himani, and Garg Rajeev. "ORAL DISSOLVING FILMS: A REVIEW." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 10 (2018): 10315–26. https://doi.org/10.5281/zenodo.1466025.

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<em>Over the past few decades, tendency towards innovative drug delivery systems has majorly increased attempts to ensure efficacy, safety and patient acceptability. OFDFs are gaining the interest of large number of pharmaceutical industries.In the late 1970s, rapid disintegrating drug delivery system was developed as an alternative to capsules, tablets and syrups for geriatric and pediatric patients having problems in swallowing.Oral disintegrating film or strips containing water dissolving polymer retain the dosage form to be quickly hydrated by saliva, adhere to mucosa, and disintegrate wit

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Mohit Avinash Nehete, Amol Pundlik Patil, Ritesh Rohidas Bhirud, and Vijay Raghunath Patil. "Formulation & development of fast dissolving film of Resperidone." World Journal of Biology Pharmacy and Health Sciences 13, no. 3 (2023): 132–40. http://dx.doi.org/10.30574/wjbphs.2023.13.3.0120.

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Risperidone, an Antipsychotic drugs. Risperidone undergoes first pass metabolism on oral administration resulting in reduced bioavailability (60%). Thus the objective of the present study was to formulate and evaluate Fast Dissolving Film of Risperidone to overcome the limitation of bioavailability and increase patient’s compliance. In the present study Fast Dissolving Film were prepared by solvent-casting method using hydrophilic polymer HPMC K4M and PEG 400 as plasticizer. The eighteen formulations were prepared by the application of heat drying technique and evaluated for the fast dissolvin

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Mohit, Avinash Nehete, Pundlik Patil Amol, Rohidas Bhirud Ritesh, and Raghunath Patil Vijay. "Formulation & development of fast dissolving film of Resperidone." World Journal of Biology Pharmacy and Health Sciences 13, no. 3 (2023): 132–40. https://doi.org/10.5281/zenodo.8035762.

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Risperidone, an Antipsychotic drugs. Risperidone undergoes first pass metabolism on oral administration resulting in reduced bioavailability (60%). Thus the objective of the present study was to formulate and evaluate Fast Dissolving Film of Risperidone to overcome the limitation of bioavailability and increase patient’s compliance. In the present study Fast Dissolving Film were prepared by solvent-casting method using hydrophilic polymer HPMC K4M and PEG 400 as plasticizer. The eighteen formulations were prepared by the application of heat drying technique and evaluated for the fast dis

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Chonkar, Ankita D., S. T. Bhagawati, and N. Udupa. "An Overview on Fast Dissolving Oral Films." Asian Journal of Pharmacy and Technology 5, no. 3 (2015): 129. http://dx.doi.org/10.5958/2231-5713.2015.00020.3.

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J A, Patel, and Prof Katarnaware A B. "FAST DISSOLVING ORAL DISINTEGRATING FILMS OF VALSARTAN." International Journal of Engineering Applied Sciences and Technology 6, no. 9 (2022): 261–71. http://dx.doi.org/10.33564/ijeast.2022.v06i09.038.

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R, Karthik D., H. S. Keerthy, and Rajkumar Prasad Yadav. "A Review on Fast Dissolving Oral Films." Asian Journal of Pharmaceutical Research and Development 9, no. 3 (2021): 122–28. http://dx.doi.org/10.22270/ajprd.v9i3.969.

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Oral route are the most convenient and common route of administration of drug because of the low cost of therapy and ease of administration lead to high levels of patient compliance as in the form of tablets and capsules. Generally In some cases, the oral solid dosage form may become difficult especially in swallowing. So to overcome these problems, fast dissolving drug delivery systems have been developed which disintegrate or dissolve within one minute when placed in the mouth without water or chewing. These are the formulations administered without water. These thin sized oral film stripes

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Soni, Shashank, and Saurabh Singh. "Systemic Review on Fast Dissolving Oral Films." International Journal of Research Publication and Reviews 6, no. 5 (2025): 3357–69. https://doi.org/10.55248/gengpi.6.0525.1712.

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Swetha., M. "Comprehensive Review on Nanosuspension Loaded in Oral Dissolving Film-The Trending Approach to Enhance the Solubility of BCS Class-II Drugs." International Journal of Pharmacy and Biological Sciences (IJPBS) 14, no. 1 (2024): 68–75. https://doi.org/10.5281/zenodo.10828605.

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<strong>Abstract</strong>The significance and bright future of the novel dosage form are discussed in the current paper. A nanosuspension is a colloidal drug dispersion at a size smaller than one micron. Reviewing innovative elements of novel dosage form nanosuspension with oral dissolving films is the aim of this work. Pharmaceutical companies frequently employ nanotechnology-based methods to enhance their water-insoluble medications. This aims to develop nanosuspension with oral fast dissolving films which improves oral bioavailability of drugs. The use of nanosuspension in the manufacture o

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Sharma, Pravin Kumar, Pankaj Kumar Sharma, Gajanan N. Darwhekar, and Birendra Shrivastava. "AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS." International Journal of Drug Regulatory Affairs 6, no. 1 (2018): 1–7. http://dx.doi.org/10.22270/journal.v6i1.220.

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Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of act

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Sharma, Pravin Kumar, Pankaj Kumar Sharma, Gajanan N. Darwhekar, and Birendra Shrivastava. "AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS." International Journal of Drug Regulatory Affairs 6, no. 1 (2018): 1–7. http://dx.doi.org/10.22270/ijdra.v6i1.220.

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Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of act

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Wadher, Kamlesh J., Charvi J. Kubde, Swati D. Malkote, Manasi S. Thakre, Chetna J. Shelote, and Milind J. Umekar. "Formulation and Characterization of Montelukast Sodium Mouth Dissolving Film Using Cress Seed Mucilage." Journal of Drug Delivery and Therapeutics 13, no. 2 (2023): 16–20. http://dx.doi.org/10.22270/jddt.v13i2.5891.

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There is a rising interest in the development of orodispersible films (ODFs) as an alternative to fast dissolving tablets which is attributed to their faster dissolution rate, higher durability, and better patient compliance. Owing to its rheological and also various functional properties, many researchers tried to discover some of the pharmaceutical applications of L. sativum in the development of various dosage forms, in addition to its therapeutic studies, such as binding, dissolving, gelling and sustained release dosage form. The fast-dissolving oral film of the Montelukast sodium by using

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Santosh Kumar, Rada, and T. Naga Satya Yagnesh. "Oral dissolving films: an effective tool for fast therapeutic action." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 492–500. http://dx.doi.org/10.22270/jddt.v9i1-s.2395.

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The oral route is most familiar route as it has low cost of therapy and helps in the ease of administration of therapeutic agents which lead to high levels of patient compliance. The most known oral solid dosage forms are tablets and capsules. Many patients’ particularly pediatric and geriatric patients find it difficult to swallow tablets and hard gelatin capsules and do not take their medicines as prescribed. Difficulty in swallowing or dysphagia is identified to afflict nearly 35% of the general population. To reduce these difficulties, the growth of several fast dissolving drug delivery sy

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Patil, Pallavi C., S. K. Shrivastava, Vaidehi S., and Ashwini P. "ORAL FAST DISSOLVING DRUG DELIVERY SYSTEM: A MODERN APPROACH FOR PATIENT COMPLIANCE." International Journal of Drug Regulatory Affairs 2, no. 2 (2018): 49–60. http://dx.doi.org/10.22270/ijdra.v2i2.131.

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This review represents importance of mouth dissolving films as compared to other oral dosage forms. Fast dissolving oral drug delivery system are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth without need of water or chewing. First developed fast dissolving dosage form in formulation and the rapid disintegrating properties were obtained through a special procedure or formulation modification, hence mouth dissolving film is proved to be better alternative in such cases. This fast dissolving drug delivery system is suited for the drugs which undergo hig

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Vishnav, Rahul, Maya Sharma, Awadh Kishore, PK Choudhari PK Choudhari, and Ashwini Suryawanshi. "Fast Dissolving Film of Ondansetron Hydrochloride." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 1317–24. https://doi.org/10.35629/4494-100113171324.

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The goal of this study was to develop a fastdissolving film for a water-soluble drug, providing a more convenient and user-friendly alternative to conventional oral dosage forms. The films were fabricated using the solvent casting method with the film-forming polymer Hydroxypropyl Methylcellulose (HPMC). The release profile of Ondansetron HCl demonstrated rapid dissolution, with 97.5% release occurring within 35 seconds. Among all the optimized formulations, F2 exhibited the best performance, making it the most suitable batch. The stability study conducted over 90 days showed that the optimize

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