Relevant bibliographies by topics / Fast Spiking Interneurons (FSINs)

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Academic literature on the topic 'Fast Spiking Interneurons (FSINs)'

Author: Grafiati
Published: 6 September 2023

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Journal articles on the topic "Fast Spiking Interneurons (FSINs)"

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Higgs, Matthew H., and Charles J. Wilson. "Frequency-dependent entrainment of striatal fast-spiking interneurons." Journal of Neurophysiology 122, no. 3 (2019): 1060–72. http://dx.doi.org/10.1152/jn.00369.2019.

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Striatal fast-spiking interneurons (FSIs) fire in variable-length runs of action potentials at 20–200 spikes/s separated by pauses. In vivo, or with fluctuating applied current, both runs and pauses become briefer and more variable. During runs, spikes are entrained specifically to gamma-frequency components of the input fluctuations. We stimulated parvalbumin-expressing striatal FSIs in mouse brain slices with broadband noise currents added to direct current steps and measured spike entrainment across all frequencies. As the constant current level was increased, FSIs produced longer runs and
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Marche, Kévin, and Paul Apicella. "Changes in activity of fast-spiking interneurons of the monkey striatum during reaching at a visual target." Journal of Neurophysiology 117, no. 1 (2017): 65–78. http://dx.doi.org/10.1152/jn.00566.2016.

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Recent works highlight the importance of local inhibitory interneurons in regulating the function of the striatum. In particular, fast-spiking interneurons (FSIs), which likely correspond to a subgroup of GABAergic interneurons, have been involved in the control of movement by exerting strong inhibition on striatal output pathways. However, little is known about the exact contribution of these presumed interneurons in movement preparation, initiation, and execution. We recorded the activity of FSIs in the striatum of monkeys as they performed reaching movements to a visual target under two tas
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Banaie Boroujeni, Kianoush, Mariann Oemisch, Seyed Alireza Hassani, and Thilo Womelsdorf. "Fast spiking interneuron activity in primate striatum tracks learning of attention cues." Proceedings of the National Academy of Sciences 117, no. 30 (2020): 18049–58. http://dx.doi.org/10.1073/pnas.2001348117.

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Cognitive flexibility depends on a fast neural learning mechanism for enhancing momentary relevant over irrelevant information. A possible neural mechanism realizing this enhancement uses fast spiking interneurons (FSIs) in the striatum to train striatal projection neurons to gate relevant and suppress distracting cortical inputs. We found support for such a mechanism in nonhuman primates during the flexible adjustment of visual attention in a reversal learning task. FSI activity was modulated by visual attention cues during feature-based learning. One FSI subpopulation showed stronger activat
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Damodaran, Sriraman, Rebekah C. Evans, and Kim T. Blackwell. "Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum." Journal of Neurophysiology 111, no. 4 (2014): 836–48. http://dx.doi.org/10.1152/jn.00382.2013.

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The inhibitory circuits of the striatum are known to be critical for motor function, yet their contributions to Parkinsonian motor deficits are not clear. Altered firing in the globus pallidus suggests that striatal medium spiny neurons (MSN) of the direct (D1 MSN) and indirect pathway (D2 MSN) are imbalanced during dopamine depletion. Both MSN classes receive inhibitory input from each other and from inhibitory interneurons within the striatum, specifically the fast-spiking interneurons (FSI). To investigate the role of inhibition in maintaining striatal balance, we developed a biologically-r
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Bakhurin, Konstantin I., Victor Mac, Peyman Golshani, and Sotiris C. Masmanidis. "Temporal correlations among functionally specialized striatal neural ensembles in reward-conditioned mice." Journal of Neurophysiology 115, no. 3 (2016): 1521–32. http://dx.doi.org/10.1152/jn.01037.2015.

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As the major input to the basal ganglia, the striatum is innervated by a wide range of other areas. Overlapping input from these regions is speculated to influence temporal correlations among striatal ensembles. However, the network dynamics among behaviorally related neural populations in the striatum has not been extensively studied. We used large-scale neural recordings to monitor activity from striatal ensembles in mice undergoing Pavlovian reward conditioning. A subpopulation of putative medium spiny projection neurons (MSNs) was found to discriminate between cues that predicted the deliv
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Govindaiah, Gubbi, Rong-Jian Liu, and Yanyan Wang. "Dopamine D2L Receptor Deficiency Alters Neuronal Excitability and Spine Formation in Mouse Striatum." Biomedicines 10, no. 1 (2022): 101. http://dx.doi.org/10.3390/biomedicines10010101.

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The striatum contains several types of neurons including medium spiny projection neurons (MSNs), cholinergic interneurons (ChIs), and fast-spiking interneurons (FSIs). Modulating the activity of these neurons by the dopamine D2 receptor (D2R) can greatly impact motor control and movement disorders. D2R exists in two isoforms: D2L and D2S. Here, we assessed whether alterations in the D2L and D2S expression levels affect neuronal excitability and synaptic function in striatal neurons. We observed that quinpirole inhibited the firing rate of all three types of striatal neurons in wild-type (WT) m
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Xiao, Guihua, Yilin Song, Yu Zhang, et al. "Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson’s Disease." Biosensors 10, no. 10 (2020): 136. http://dx.doi.org/10.3390/bios10100136.

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(1) Background: Deep brain stimulation (DBS) is considered as an efficient treatment method for alleviating motor symptoms in Parkinson’s disease (PD), while different stimulation frequency effects on the specific neuron patterns at the cellular level remain unknown. (2) Methods: In this work, nanocomposites-modified implantable microelectrode arrays (MEAs) were fabricated to synchronously record changes of dopamine (DA) concentration and striatal neuron firing in the striatum during subthalamic nucleus DBS, and different responses of medium spiny projecting neurons (MSNs) and fast spiking int
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Shaheen, Hina, and Roderick Melnik. "Deep Brain Stimulation with a Computational Model for the Cortex-Thalamus-Basal-Ganglia System and Network Dynamics of Neurological Disorders." Computational and Mathematical Methods 2022 (February 13, 2022): 1–17. http://dx.doi.org/10.1155/2022/8998150.

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Deep brain stimulation (DBS) can alleviate the movement disorders like Parkinson’s disease (PD). Indeed, it is known that aberrant beta (13-30 Hz) oscillations and the loss of dopaminergic neurons in the basal ganglia-thalamus (BGTH) and cortex characterize the akinesia symptoms of PD. However, the relevant biophysical mechanism behind this process still remains unclear. Based on the prior striatal inhibitory model, we propose an extended BGTH model incorporating medium spine neurons (MSNs) and fast-spiking interneurons (FSIs) along with the effect of DBS. We are focusing in this paper on an o
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Kunimatsu, Jun, Shinya Yamamoto, Kazutaka Maeda, and Okihide Hikosaka. "Environment-based object values learned by local network in the striatum tail." Proceedings of the National Academy of Sciences 118, no. 4 (2021): e2013623118. http://dx.doi.org/10.1073/pnas.2013623118.

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Basal ganglia contribute to object-value learning, which is critical for survival. The underlying neuronal mechanism is the association of each object with its rewarding outcome. However, object values may change in different environments and we then need to choose different objects accordingly. The mechanism of this environment-based value learning is unknown. To address this question, we created an environment-based value task in which the value of each object was reversed depending on the two scene-environments (X and Y). After experiencing this task repeatedly, the monkeys became able to s
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Bryson, Alexander, Samuel F. Berkovic, Steven Petrou, and David B. Grayden. "State transitions through inhibitory interneurons in a cortical network model." PLOS Computational Biology 17, no. 10 (2021): e1009521. http://dx.doi.org/10.1371/journal.pcbi.1009521.

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Inhibitory interneurons shape the spiking characteristics and computational properties of cortical networks. Interneuron subtypes can precisely regulate cortical function but the roles of interneuron subtypes for promoting different regimes of cortical activity remains unclear. Therefore, we investigated the impact of fast spiking and non-fast spiking interneuron subtypes on cortical activity using a network model with connectivity and synaptic properties constrained by experimental data. We found that network properties were more sensitive to modulation of the fast spiking population, with re
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Dissertations / Theses on the topic "Fast Spiking Interneurons (FSINs)"

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Whittaker, Maximilian Anthony Erik. "Modulation of fast-spiking interneurons using two-pore channel blockers." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31252.

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The balance between excitatory and inhibitory synaptic transmission within and across neurons in active networks is crucial for cortical function and may allow for rapid transitions between stable network states. GABAergic interneurons mediate the majority of inhibitory transmission in the cortex, and therefore contribute to the global balance of activity in neuronal networks. Disruption in the network balance due to impaired inhibition has been implicated in several neuropsychiatric diseases (Marin 2012). Both schizophrenia and autism are two highly heritable cognitive disorders with complex
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Albieri, Giorgia. "The role of fast-spiking interneurons in cortical map plasticity." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-fastspiking-interneurons-in-cortical-map-plasticity(3d7b76ff-1833-4147-addd-6f24accbd6cc).html.

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Rodents have a topographic map in primary somatosensory cortex of the contralateral facial whiskers. A brief period of whisker trimming causes the representation of the nontrimmed whiskers (spared) to expand into the cortex that has lost its principal sensory input (deprived). It has been hypothesized that this is mediated by a period of persistent disinhibition in deprived cortex that enables the expansion of spared whisker representations. Alternatively, it has been proposed that inhibition undergoes a biphasic change with an initial, brief period of disinhibition to promote plasticity in ex
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Papasavvas, Christoforos A. "Investigating the role of fast-spiking interneurons in neocortical dynamics." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3808.

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Fast-spiking interneurons are the largest interneuronal population in neocortex. It is well documented that this population is crucial in many functions of the neocortex by subserving all aspects of neural computation, like gain control, and by enabling dynamic phenomena, like the generation of high frequency oscillations. Fast-spiking interneurons, which represent mainly the parvalbumin-expressing, soma-targeting basket cells, are also implicated in pathological dynamics, like the propagation of seizures or the impaired coordination of activity in schizophrenia. In the present thesis, I inves
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GIORDANO, Nadia Concetta. "Early, sustained and broadly-tuned discharge of fast-spiking interneurons in the premotor cortex during action planning." Doctoral thesis, Scuola Normale Superiore, 2021. http://hdl.handle.net/11384/106386.

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Preparatory neural activity in premotor areas is critical for planning and execution of voluntary movements. Previous studies in monkeys and mice have revealed how the discharges of pyramidal, excitatory neurons (PNs) encode a motor plan for an upcoming movement (Afshar et al., 2011; Chen et al., 2017; Li et al., 2015). However, the contribution of GABAergic interneurons, specifically fast-spiking interneurons (FSNs), to voluntary movements remains poorly understood. Putative premotor areas involved in action planning have been demonstrated in rodents. In particular, in mice, a premotor area
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Sivarajan, Vishalini [Verfasser], Dirk [Akademischer Betreuer] Feldmeyer, and Björn M. [Akademischer Betreuer] Kampa. "Morphological and functional characterisation of non-fast spiking interneurons in layer 4 microcircuitry of rat barrel cortex / Vishalini Sivarajan ; Dirk Feldmeyer, Björn M. Kampa." Aachen : Universitätsbibliothek der RWTH Aachen, 2017. http://d-nb.info/1158667817/34.

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Hjorth, Johannes. "Computer Modelling of Neuronal Interactions in the Striatum." Doctoral thesis, KTH, Beräkningsbiologi, CB, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-10523.

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Large parts of the cortex and the thalamus project into the striatum,which serves as the input stage of the basal ganglia. Information isintegrated in the striatal neural network and then passed on, via themedium spiny (MS) projection neurons, to the output stages of thebasal ganglia. In addition to the MS neurons there are also severaltypes of interneurons in the striatum, such as the fast spiking (FS)interneurons. I focused my research on the FS neurons, which formstrong inhibitory synapses onto the MS neurons. These striatal FSneurons are sparsely connected by electrical synapses (gap junct
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Rühlmann, Charlotta [Verfasser], Bernhard [Akademischer Betreuer] Hemmer, and Achim [Akademischer Betreuer] Berthele. "The NMDA-Receptor on Fast Spiking Parvalbumin-expressing Interneurons : Investigations on the Role of Disinhibition and its Effects on Gamma Oscillations, Cognitive Functions and Symptoms of Schizophrenia in a Mouse Model / Charlotta Rühlmann. Gutachter: Bernhard Hemmer ; Achim Berthele. Betreuer: Bernhard Hemmer." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1053467680/34.

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Dasgupta, Dabanjan. "Plasticity of Intrinsic Excitability in Fast Spiking Interneurons of the Dentate Gyrus & Its Implications for Neuronal Network Dynamics." Thesis, 2015. https://etd.iisc.ac.in/handle/2005/4079.

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Inhibitory GABAergic neurons, although forming a minor proportion of the neuronal population in the central nervous system, have been reported to be crucial for different physiological states of the brain. Among the vast diversity of this neuronal subpopulation, the fast spiking interneurons (FSINs) have been studied in great detail owing to their morphological and physiological attributes and functional correlates. Due to their perisomatic targeting and rapid spiking nature, they have been strongly associated with spike time and gain control of their target neurons in neuronal microcircuits a
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Ho, Ernest Chun Yue. "If you Want to be Slow you have to be Fast: Control of Slow Population Activities by Fast-spiking Interneurons via Network Multistability." Thesis, 2011. http://hdl.handle.net/1807/30056.

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Slow population activities (SPAs) are population activities in the brain with frequencies of less than 5 Hz. SPAs are prominent in many brain structures including the neocortex and the hippocampus. Examples of SPAs include the neocortical EEG δ waves and the hippocampal large amplitude irregular activities during NREM sleep. These in vivo SPAs are believed to play a fundamental role in brain plasticity. However, despite many experimental attempts to understand SPAs, their mechanisms are still not well understood. It is unclear how the individual neurons can sustain low frequency activities on
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Cheng, Ruey-Kuang. "Neural Coding Strategies in Cortico-Striatal Circuits Subserving Interval Timing." Diss., 2010. http://hdl.handle.net/10161/2380.

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<p>Interval timing, defined as timing and time perception in the seconds-to-minutes range, is a higher-order cognitive function that has been shown to be critically dependent upon cortico-striatal circuits in the brain. However, our understanding of how different neuronal subtypes within these circuits cooperate to subserve interval timing remains elusive. The present study was designed to investigate this issue by focusing on the spike waveforms of neurons and their synchronous firing patterns with local field potentials (LFPs) recorded from cortico-striatal circuits while rats were performin
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Book chapters on the topic "Fast Spiking Interneurons (FSINs)"

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Fish, Kenneth N., Guillermo Gonzalez-Burgos, Aleksey V. Zaitsev, and David A. Lewis. "Histological Characterization of Physiologically Determined Fast-Spiking Interneurons in Slices of Primate Dorsolateral Prefrontal Cortex." In Isolated Central Nervous System Circuits. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-020-5_4.

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Zeberg, Hugo, Nathan W. Gouwens, Kunichika Tsumoto, Takashi Tateno, Kazuyuki Aihara, and Hugh P. C. Robinson. "Phase-Resetting Analysis of Gamma-Frequency Synchronization of Cortical Fast-Spiking Interneurons Using Synaptic-like Conductance Injection." In Phase Response Curves in Neuroscience. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-0739-3_20.

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Behrens, M. Margarita. "Studying Schizophrenia in a Dish: Use of Primary Neuronal Cultures to Study the Long-Term Effects of NMDA Receptor Antagonists on Parvalbumin-Positive Fast-Spiking Interneurons." In Animal Models of Schizophrenia and Related Disorders. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-157-4_6.

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Chesselet, Marie-Françoise, Joshua L. Plotkin, Nanping Wu, and Michael S. Levine. "Development of striatal fast-spiking GABAergic interneurons." In Progress in Brain Research. Elsevier, 2007. http://dx.doi.org/10.1016/s0079-6123(06)60015-0.

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Fasching, Liana, Melanie Brady, and Flora M. Vaccarino. "Cellular and Molecular Pathology in Tourette Syndrome." In Tourette Syndrome, 2nd ed., edited by Liana Fasching, Melanie Brady, and Flora M. Vaccarino. Oxford University Press, 2022. http://dx.doi.org/10.1093/med/9780197543214.003.0012.

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Abstract This chapter summarizes the available literature and data on pathological findings in Tourette syndrome. In severe, unremitting Tourette syndrome, there are decreases in somatostatin-positive/nitric oxide synthase–positive interneurons, fast spiking parvalbumin-positive/γ-aminobutyric acid-ergic interneurons, as well as tonically active cholinergic interneurons in the caudate nucleus and putamen. There is also a prominent increase in inflammation throughout the basal ganglia along with activation of microglial cells. Overall, neuroimaging studies suggest that the basal ganglia, a set of nuclei situated deep within the cerebral cortical hemispheres, are a central component of the pathophysiology of TS. These findings are discussed in light of current views on the pathogenic mechanisms underlying tic disorders.
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Merchant, Hugo, and Apostolos P. Georgopoulos. "Inhibitory Mechanisms in the Motor Cortical Circuit." In Handbook of Brain Microcircuits, edited by Gordon M. Shepherd and Sten Grillner. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190636111.003.0006.

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Inhibitory mechanisms are crucial for the integrated operation of the motor cortical circuit. Local inhibition is exerted by interneurons that are GABAergic, nonpyramidal cells with short, nonprojecting axons. Interneurons can be classified into at least two groups: fast-spiking (FS) neurons and instrinsic bursting (IB) neurons. In the primary motor cortex, FS cells may sculpe the tuning dispersion of directionally selective putative pyramidal cells during reaching in behaving monkeys. Analysis of putative interneuronal activity also allowed to discard the role of inhibition as a gating mechanism in motor control. The development of high-density, semichronic electrode systems for extracellular recordings in behaving primates will allow a closer investigation of the role of interneuronal inhibition in directional tuning and voluntary motor control. The results discussed in this chapter agree with the authors’ proposal that local inhibitory mechanisms may be intimately involved in controlling the directional accuracy and speed of the reaching movement.
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