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1
Zhu, Xin. "Genetic interactions patterning the Tribolium fate map." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/35787.
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Doctor of PhilosophyDivision of Biology
Susan J. Brown
A segmented body plan is conserved in vertebrates and arthropods. Comparative studies implicate a conserved mode of A-P axis patterning and segmentation among vertebrates: Wnt signaling is involved in fate map patterning along the A-P axis and in segmentation in the posterior region of the embryo. On the other hand, comparative studies in arthropods have revealed distinct modes of development between long and short germ insects, which differ both morphologically and genetically. In the short germ insect Tribolium, a Wnt activity gradient contributes to A-P axis patterning and generates a posterior Tc-cad expression gradient that regulates segmentation through a pair-rule gene clock, forming segments sequentially as in vertebrates. In contrast, instead of Wnt activity, a hierarchy of regulatory genes regionalizes the blastoderm and defines segments simultaneously in the long germ insect Drosophila. In Tribolium, Tc-zen-1, Tc-otd-1 and Tc-cad play key roles in patterning serosa, head and trunk regions, respectively, of the blastoderm fate map, which are impacted by changes in Wnt activity levels. However, interactions between these genetic factors have not been described. My work revealed that cross talk between the Wnt and Dpp signaling pathways regulates the expression of Tc-zen-1 to determine the serosa. Furthermore, mutually repression between Tcotd-1 and Tc-cad defines the head and trunk regions while mutual repression between Tc-zen-1 and cad determines the posterior extent of the dorsal serosa. Analysis of target genes of the posterior Tc-cad gradient indicates that the Tc-cad gradient regulates the serial expression of gap genes, which are predominately regulators of Hox genes. Thus the posterior Tc-cad gradient determines segment formation through regulation of pair-rule genes in the insect segmentation clock, and defines segmental identity through regulation of gap genes. Given its effect on Tc-zen-1 and Tc-cad, the Wnt activity gradient is a key organizer of the Tribolium blastoderm fate map. Since homologs of these genes as well as the Wnt signaling pathway have also been identified in several other short germ band insects, and affect cell fates along the A-P body axis, this work provides a new paradigm for the short germ mode of development to guide studies in other arthropods.
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ICHIKAWA, KENJI, TAKANORI NAKAMURA, YUJI KUBOTA, and MUTSUHIRO TAKEKAWA. "REGULATION OF STRESS-ACTIVATED MAP KINASE PATHWAYS DURING CELL FATE DECISIONS." Nagoya University School of Medicine, 2011. http://hdl.handle.net/2237/14910.
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Bhattacharyya, Sujata Fraser Scott E. "Embryonic origin of the olfactory sensory system : fate map, lineage analysis and specification of the avian olefactory placode /." Diss., Pasadena, Calif. : California Institute of Technology, 2005. http://resolver.caltech.edu/CaltechETD:etd-05282005-205447.
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Martínez, Brito Izacar Jesús. "Quantitative structure fate relationships for multimedia environmental analysis." Doctoral thesis, Universitat Rovira i Virgili, 2010. http://hdl.handle.net/10803/8590.
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Key physicochemical properties for a wide spectrum of chemical pollutants are unknown. This thesis analyses the prospect of assessing the environmental distribution of chemicals directly from supervised learning algorithms using molecular descriptors, rather than from multimedia environmental models (MEMs) using several physicochemical properties estimated from QSARs. Dimensionless compartmental mass ratios of 468 validation chemicals were compared, in logarithmic units, between: a) SimpleBox 3, a Level III MEM, propagating random property values within statistical distributions of widely recommended QSARs; and, b) Support Vector Regressions (SVRs), acting as Quantitative Structure-Fate Relationships (QSFRs), linking mass ratios to molecular weight and constituent counts (atoms, bonds, functional groups and rings) for training chemicals. Best predictions were obtained for test and validation chemicals optimally found to be within the domain of applicability of the QSFRs, evidenced by low MAE and high q2 values (in air, MAE≤0.54 and q2≥0.92; in water, MAE≤0.27 and q2≥0.92).Las propiedades fisicoquímicas de un gran espectro de contaminantes químicos son desconocidas. Esta tesis analiza la posibilidad de evaluar la distribución ambiental de compuestos utilizando algoritmos de aprendizaje supervisados alimentados con descriptores moleculares, en vez de modelos ambientales multimedia alimentados con propiedades estimadas por QSARs. Se han comparado fracciones másicas adimensionales, en unidades logarítmicas, de 468 compuestos entre: a) SimpleBox 3, un modelo de nivel III, propagando valores aleatorios de propiedades dentro de distribuciones estadísticas de QSARs recomendados; y, b) regresiones de vectores soporte (SVRs) actuando como relaciones cuantitativas de estructura y destino (QSFRs), relacionando fracciones másicas con pesos moleculares y cuentas de constituyentes (átomos, enlaces, grupos funcionales y anillos) para compuestos de entrenamiento. Las mejores predicciones resultaron para compuestos de test y validación correctamente localizados dentro del dominio de aplicabilidad de los QSFRs, evidenciado por valores bajos de MAE y valores altos de q2 (en aire, MAE≤0.54 y q2≥0.92; en agua, MAE≤0.27 y q2≥0.92).
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Moore, Preston D. "Mosaic Analysis with Double Markers (MADM) as a Method to Map Cell Fates in Adult Mouse Taste Buds." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etd/1764.
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Taste buds are chemosensory endorgans embedded in the oral epithelium composed of cells that undergo continuous replacement. Mature taste cells live on average 10-14 days and are replaced by new cells when they die. However, the mechanism by which taste cells are produced and integrated into the taste bud as mature taste cells remains unknown. Previous studies approached this issue from either cell cycle gene expression properties or lineage tracing of precursor cells. In our study, we apply a new fate mapping technique that combines these two ideas. This technique, Mosaic Analysis with Double Markers, allows for simultaneous gene knockout and subsequent tracking of single cells. This allows us to study the potency of precursor cells supplying the taste bud while analyzing how gene function regulates the maturation pathway these taste cells take. The following experiments illustrate the initial phase of this investigation.
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Araújo, José Rodolfo Bezerra Mesquita. "Estruturas de fase geradas por órbitas complexas variando parâmetros reais." Universidade Federal da Paraíba, 2016. http://tede.biblioteca.ufpb.br:8080/handle/tede/9505.
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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
This work is a computational mapping of the phase space of iterated maps. Initially, a review of the real Hénon map is presented, aiming at the identification of patterns in the stability regions of the parameter space. Then, the algorithm developed is extended to allow complex variables, while still requiring parameters to be real. This procedure permits the observation of different stable loci in phase space. Finally, developed tools and observations are applied in a comparative study of the generalized cubic Hénon map.
Este trabalho lida com o mapeamento computacional do espaço de fase de mapas iterativos. Inicialmente é feita uma revisão sobre o mapa de Hénon real, tendo por objetivo a identificação de padrões nas regiões de estabilidade de seu espaço de parâmetros. Em seguida, o algoritmo desenvolvido para tal intento é estendido para o caso em que as variáveis da transformação são considerados como números complexos. Os parâmetros, contudo, serão mantidos no domínio dos reais durante esse processo. Esse procedimento permitirá a observação de áreas estáveis antes não encontradas no espaço de fase. Por fim, as ferramentas e observações feitas serão utilizadas para o estudo do mapa generalizado de Hénon de ordem cúbica.
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Bundy, Geraint Llewellyn. "Automated cartographic generalization with a triangulated spatial model." Thesis, University of South Wales, 1996. https://pure.southwales.ac.uk/en/studentthesis/automated-cartographic-generalization-with-a-triangulated-spatial-model(754893a1-faae-4191-9e36-a15854deb36d).html.
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This thesis describes a doctoral project which has addressed some of the problems of automatically performing cartographic generalization in a holistic manner, that is, processing the map features in the context of the whole map rather than individual features in isolation. The approach is based on two key ideas: firstly, that the map surface can be represented by a structure based on simplicial complexes which provides useful relationships for topology and proximity and facilitates many of the fundamental generalization operations. Secondly, that the epistemological structures needed for generalization can be represented by a hierarchy of "context" frames, each of which encapsulate the knowledge required to recognize, generalize and resolve a cartographic situation. A data structure that uses simplicial complexes to represent map objects has been designed and implemented. Each object is described by a set of two-dimensional simplices (triangles) that are maintained in the form of a constrained Delaunay triangulation. This structure gives a fully connected two-dimensional plenum that stores important spatial relationships such as "enclosed", "adjacent" and "between" explicitly. This simplicial data structure (SDS), as it is called, can be used directly to perform several types of operations necessary for automatic generalization, for example, automatic overlap detection, displacement, merging, enlargement, simplification of building outlines and skeletonization. Algorithms for many of these operators have been implemented while others are proposed. Pseudo-code and descriptions are used to document many of these operators, results are given and discussed. A frame-based architecture is proposed which provides a framework for the representation and application of knowledge for generalization. The project was funded by an EPSRC CASE studentship in collaboration with the Ordnance Survey.
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Wood, Nolan David. "The fate of levodopa in rats and man." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328529.
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Cohen, Jonathan. "The regulation of postprandial lipemia in man." Doctoral thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/27177.
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The regulation of the serum triglyceride responses to fat ingestion have been examined in normolipidemic men. To evaluate the existing methods for comparing chylomicron-triglyceride clearance, the oral and intravenous fat tolerance tests and a steady state duodenal perfusion method were compared. Good correlations (r > 0.8) were found between each of these methods. Since the intravenous fat tolerance test is independent of fat absorption, these data suggested that the serum triglyceride response to fat feeding was largely determined by the rate of chylomicron-triglyceride clearance. To determine the influence of the quantity and type of meal fat on postprandial serum triglyceride concentrations, the serum triglyceride responses to three different doses of dairy cream, and to standard doses of olive and sunflower oil were examined. For a given type of fat, the magnitude of postprandial lipemia (the integrated serum triglyceride excursion) varied directly with the quantity of fat in the meal. This finding suggested that the chylomicron- triglyceride clearance system(s) did not become saturated even after large fat meals. In addition, it appeared that the hormonal factors released in response to fat ingestion (some of which are known to increase lipoprotein lipase activity in vitro) did not increase the rate of chylomicron-triglyceride clearance. If the quantity of fat in a meal was fixed, then postprandial lipemia increased with increasing saturation of the triglyceride fatty acids. These differences did not appear to reflect differences in triglyceride absorption. Since acute fat feeding per se did not appear to stimulate chylomicron-triglyceride clearance, the effects of dietary proteins and carbohydrates were studied. The addition of up to 35g protein to a standard test meal did not affect postprandial lipemia. These results were supported by the observation that protein ingestion did not affect intravenous fat tolerance. Postprandial serum triglyceride concentrations were significantly influenced by carbohydrate ingestion. Fructose (50g) and sucrose (100g) markedly increased postprandial lipemia, although glucose ingestion did not. In agreement with earlier studies, glucose ingestion decreased serum triglyceride concentrations 2 hours after the meal. This effect was abolished by intraduodenal fat administration and by substituting starch for glucose in the test meal. The effects of glucose could be reproduced by iso-osmotic quantities of urea, however. These findings suggested that glucose ingestion did not increase chylomicron -triglyceride clearance. It is more likely that glucose delayed the absorption of triglycerides by slowing gastric emptying, and that this effect was partly related to the increased osmolarity of glucose- containing meals. The effects of chronic exercise on postprandial lipemia and chylomicron-triglyceride clearance were determined in endurance- adapted athletes. The serum triglyceride responses to large and small fat meals were lower in athletes than in sedentary men with comparable fasting triglyceride concentrations. These differences were not eliminated by a single bout of acute exercise in the sedentary men. The clearance of intravenously administered lntralipid, and chylomicron -triglyceride clearance assessed from steady state chylomicron-triglyceride concentrations during duodenal fat perfusion were faster in athletes than in the sedentary men. These data suggested that the low postprandial lipemia in athletes reflects increased chylomicron-triglyceride clearance caused by increased activity of the triglyceride clearing system(s). Given these considerations. it appears that the pathway(s) for chylomicron triglyceride clearance are extremely efficient in normal men and that these pathways are not subject to acute physiological regulation.
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Berg, Frida. "Genetic Analysis of Fat Metabolism in Domestic Pigs and their Wild Ancestor." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7089.
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Moser, Denise Aparecida. "Mal de Alzheimer na primeira fase." Florianópolis, SC, 2011. http://repositorio.ufsc.br/xmlui/handle/123456789/95191.
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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Lingüistica, Florianópolis, 2011Made available in DSpace on 2012-10-25T21:56:55Z (GMT). No. of bitstreams: 1 294982.pdf: 1592587 bytes, checksum: a8e04cd94ad8d42b16575133bbc4e275 (MD5)
Esta pesquisa teve por finalidade desenvolver um estudo para verificar se é possível auxiliar no diagnóstico de prováveis portadores de mal de Alzheimer na primeira fase a partir dos sintomas linguísticos, mais precisamente na área fonológica. A investigação compreendeu uma pesquisa do tipo bibliográfica e estudo de caso em que participaram dois sujeitos residentes no Ancionato Bethesda, localizado em Joinville, Santa Catarina, Brasil. Para a seleção dos sujeitos como sendo prováveis portadores de mal de Alzheimer de estágio inicial, recorreu-se ao auxílio de profissionais da área da saúde em que analisaram os prontuários, os laudos de tomografia computadorizada de crânio e as avaliações cognitivas (Mini-Exame do Estado Mental - MEEM) deles. Posteriormente, realizou-se a coleta das falas espontâneas que foram gravadas e transcritas foneticamente. Os processos fonológicos e a Fonologia de Geometria de Traços foram os modelos teóricos escolhidos para a análise dos dados, mas os resultados mostraram que os sujeitos não possuem déficits no nível fonológico. Portanto, essas teorias não foram aplicadas. Além disso, foram observadas algumas variáveis extralinguísticas que revelaram a não interferência delas no processamento fonológico desses sujeitos. Verificou-se, assim, que não se confirmou a expectativa da pesquisa uma vez que se estava a favor da teoria de Croot et al. (2000), ou seja, de que os prováveis portadores de mal de Alzheimer de primeira fase apresentassem deterioração fonológica.
This research was aimed to assess if it is possible to create a methodology to assist in the diagnosis of Alzheimer#s disease in its early stages, when problems with speech and language appear, more precisely in the phonological domain. The investigation involved bibliographical research and a case study of two subjects admitted to Bethesda care home in Joinville, Santa Catarina, Brazil. Patient selection was performed by healthcare professionals who examined the medical records, cranial computed tomography findings and cognitive assessments (Mini Mental State Examination - MEEM) of the patients. Afterwards, spontaneous speech material was collected, recorded and phonetically transcribed. The phonological processes and the Geometry of Phonological Features were the theoretical models selected for data analysis. However, the tests showed no phonological deficit. Thus, the referred theories were not applied. Besides, some extralinguistic variables were found to have no influence on the phonological processing of the subjects. Thus, the expectations of the present research were not met, because it supported the theory of Croot et al. (2000), according to which Alzheimer#s patients in the earlier stages of the disease would present phonological impairment.
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Dasgupta, Sankarshan. "3D Face Reconstruction From Front And Profile Image." University of Dayton / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1626689472561706.
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Mukhtar, M. R. "Respiratory aspects of the diving response in man." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356533.
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Dutra, Victor Hugo de Castro. "Em face do mal: uma propedêutica do conceito de mal em Paul Ricoeur." Universidade Federal de Juiz de Fora, 2012. https://repositorio.ufjf.br/jspui/handle/ufjf/1871.
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CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
A presente dissertação pretende explorar o conceito de mal, na obra de Paul Ricoeur (1923- 2005). Para isso avaliamos sua obra como um todo, mas com foco em três livros, pois os mesmos destacam os momentos de interpretação, do nosso autor, no que tange sua aproximação do problema do mal. São eles: THE SYMBOLISM OF EVIL, O MAL: UM DESAFIO À FILOSOFIA E À TEOLOGIA, e O SI-MESMO COMO UM OUTRO. Contudo, invertemos a ordem cronológica dos textos para uma abordagem original que prima chegar à maneira de como Paul Ricoeur propõe uma solução ao problema do mal. Desenvolvemos como o autor interpreta que a história da filosofia e a história da teologia desenvolveram o problema do mal, e a partir daí expomos como nosso autor o aborda, isto é na perspectiva de uma pessoa que sofre. Para então verificar como as raízes da interpretação e possível solução são encontradas nos mitos e símbolos do mal, e mais como o homem é falível e frágil em relação ao problema do mal. Para então, enfim, explorar sua pequena ética. Onde acreditamos ser possível concluir o combate ao mal através das instituições justas.
This present thesis will explore the concept of evil, in the work of Paul Ricoeur (1923-2005). To do this we evaluate his work as a whole, but focused on three books, as they highlight moments of interpretation, of our author, regarding their approach to the problem of evil. They are: THE SYMBOLISM OF EVIL, EVIL: A CHALLENGE TO PHILOSOPHY AND THEOLOGY, and THE ONESELF AS ANOTHER. But we inverted the chronological order of the texts to make an original approach that excels as a way to get to Paul Ricoeur proposal of a solution to the problem of evil. We have exposed how, as the author interprets the history of philosophy and history of theology, he developed the problem of evil, and from there too we have exposed how our author addresses it, that is, from the perspective of a person who suffers. To then see how the roots of the interpretation and possible solution, for the problem, are founded in myths and symbols of evil, and more, how man is fallible, and fragile in relation to the problem of evil. By then, finally, exploring his small ethics. Where we believe we can finish with the confrontation against evil through just institutions.
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Saleh, Yaser. "Face recognition enhancement through the use of depth maps and deep learning." Thesis, Loughborough University, 2017. https://dspace.lboro.ac.uk/2134/26606.
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Face recognition, although being a popular area of research for over a decade has still many open research challenges. Some of these challenges include the recognition of poorly illuminated faces, recognition under pose variations and also the challenge of capturing sufficient training data to enable recognition under pose/viewpoint changes. With the appearance of cheap and effective multimodal image capture hardware, such as the Microsoft Kinect device, new possibilities of research have been uncovered. One opportunity is to explore the potential use of the depth maps generated by the Kinect as an additional data source to recognize human faces under low levels of scene illumination, and to generate new images through creating a 3D model using the depth maps and visible-spectrum/RGB images that can then be used to enhance face recognition accuracy by improving the training phase of a classification task. With the goal of enhancing face recognition, this research first investigated how depth maps, since not affected by illumination, can improve face recognition, if algorithms traditionally used in face recognition were used. To this effect a number of popular benchmark face recognition algorithms are tested. It is proved that algorithms based on LBP and Eigenfaces are able to provide high level of accuracy in face recognition due to the significantly high resolution of the depth map images generated by the latest version of the Kinect device. To complement this work a novel algorithm named the Dense Feature Detector is presented and is proven to be effective in face recognition using depth map images, in particular under wellilluminated conditions. Another technique that was presented for the goal of enhancing face recognition is to be able to reconstruct face images in different angles, through the use of the data of one frontal RGB image and the corresponding depth map captured by the Kinect, using faster and effective 3D object reconstruction technique. Using the Overfeat network based on Convolutional Neural Networks for feature extraction and a SVM for classification it is shown that a technically unlimited number of multiple views can be created from the proposed 3D model that consists features of the face if captured real at similar angles. Thus these images can be used as real training images, thus removing the need to capture many examples of a facial image from different viewpoints for the training of the image classifier. Thus the proposed 3D model will save significant amount of time and effort in capturing sufficient training data that is essential in recognition of the human face under variations of pose/viewpoint. The thesis argues that the same approach can also be used as a novel approach to face recognition, which promises significantly high levels of face recognition accuracy base on depth images. Finally following the recent trends in replacing traditional face recognition algorithms with the effective use of deep learning networks, the thesis investigates the use of four popular networks, VGG-16, VGG-19, VGG-S and GoogLeNet in depth maps based face recognition and proposes the effective use of Transfer Learning to enhance the performance of such Deep Learning networks.
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Hantehzadeh, Neda. "3-D Face Recognition using the Discrete Cosine Transform (DCT)." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1964658571&sid=3&Fmt=2&clientId=1509&RQT=309&VName=PQD.
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Abdallah, Abdallah Sabry. "Investigation of New Techniques for Face detection." Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/33191.
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The task of detecting human faces within either a still image or a video frame is one of the most popular object detection problems. For the last twenty years researchers have shown great interest in this problem because it is an essential pre-processing stage for computing systems that process human faces as input data. Example applications include face recognition systems, vision systems for autonomous robots, human computer interaction systems (HCI), surveillance systems, biometric based authentication systems, video transmission and video compression systems, and content based image retrieval systems.
In this thesis, non-traditional methods are investigated for detecting human faces within color images or video frames. The attempted methods are chosen such that the required computing power and memory consumption are adequate for real-time hardware implementation. First, a standard color image database is introduced in order to accomplish fair evaluation and benchmarking of face detection and skin segmentation approaches. Next, a new pre-processing scheme based on skin segmentation is presented to prepare the input image for feature extraction. The presented pre-processing scheme requires relatively low computing power and memory needs. Then, several feature extraction techniques are evaluated. This thesis introduces feature extraction based on Two Dimensional Discrete Cosine Transform (2D-DCT), Two Dimensional Discrete Wavelet Transform (2D-DWT), geometrical moment invariants, and edge detection. It also attempts to construct a hybrid feature vector by the fusion between 2D-DCT coefficients and edge information, as well as the fusion between 2D-DWT coefficients and geometrical moments. A self organizing map (SOM) based classifier is used within all the experiments to distinguish between facial and non-facial samples. Two strategies are tried to make the final decision from the output of a single SOM or multiple SOM. Finally, an FPGA based framework that implements the presented techniques, is presented as well as a partial implementation.
Every presented technique has been evaluated consistently using the same dataset. The experiments show very promising results. The highest detection rate of 89.2% was obtained when using a fusion between DCT coefficients and edge information to construct the feature vector. A second highest rate of 88.7% was achieved by using a fusion between DWT coefficients and geometrical moments. Finally, a third highest rate of 85.2% was obtained by calculating the moments of edges.Master of Science
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Auriti, Alexander. "Fixation and fate the meaning of obsession in Genji monogatari and Hong lou-meng /." Diss., Connect to the thesis, 2007. http://hdl.handle.net/10066/1586.
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Wigerius, Michael. "Roles of mammalian Scribble in polarity signaling, virus offense and cell-fate determination." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-39368.
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Mammalian Scribble is a target for proteins encoded by human papilloma virus, retro- and flaviviruses. Tick-borne encephalitis virus (TBEV) is a flavivirus that have evolved distinct strategies to escape antiviral responses. Information of how flaviviruses intrude on cell integrity comes from understanding of the roles that host-factors play when they interfere with viruses. The first part of this thesis describes a novel interaction between the TBEVNS5 protein and Scribble. The importance of the interaction was demonstrated by RNAi-mediated depletion of Scribble, which prevented suppression of JAK-STAT signaling by NS5. Together, these results define Scribble as a novel target for NS5. TBEV is known to cause central nervous system disease TBE in humans that can lead to cognitive dysfunction. A unifying theme in CNS related diseases are defects in neuronal extensions. We therefore addressed the effects of TBEV expression in PC12 cell differentiation, which is characterized by extensive neurite growth. Our data show that TBEVNS5 suppresses neurite outgrowth through the Rho GTPase Rac1. These findings provide evidence that Rac1 is an indirect target of NS5 in neurite inhibition. Scribble was recently implicated in spine morphogenesis. Thus, we tested the role of Scribble in neurite elongation. Depletion of Scribble in PC12 cells, reduced neurite density but increased length of those remaining. Moreover, Scribble bound components in the Ras/ERK cascade in a growth factor dependent manner. Together, these results demonstrate that Scribble controls neurite elongation by scaffolding MAPK components. Moreover, as loss of dendritic spines, actin-rich protrusions on neurons, is a feature in cognitive dysfunction we speculate that cognitive dysfunction in TBE might involve disturbed Scribble expression by NS5. We also investigated the binding between NS1 of Influenza A virus and Scribble. The PDZ domains of Scribble are usually selective for specific C-terminal motifs in proteins. Because NS1 has a canonical PDZ motif we tested if binding to Scribble depends on this motif. We found that Scribble binds NS1; the association is dependent on the NS1 C-terminus that is recognized by PDZ3-4 of Scribble. Together, these results suggest that Scribble is a target for the H5N1 NS1 proteinAt the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: In press. Paper 3: Manuscript. Paper 4: Manuscript.
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Inan, Tolga. "3d Face Recognition With Local Shape Descriptors." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613835/index.pdf.
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This thesis represents two approaches for three dimensional face recognition. In the first approach, a generic face model is fitted to human face. Local shape descriptors are located on the nodes of generic model mesh. Discriminative local shape descriptors on the nodes are selected and fed as input into the face recognition system. In the second approach, local shape descriptors which are uniformly distributed across the face are
calculated. Among the calculated shape descriptors that are discriminative for recognition process are selected and used for three dimensional face recognition.
Both approaches are tested with widely accepted FRGCv2.0 database and experiment protocol. Reported results are better than the state-of-theart systems. Recognition performances for neutral and non-neutral faces are also reported.
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McCallum, Claire Elizabeth. "The fate of the new man : reconstructing and representing masculinity in Soviet visual culture, 1945-1965." Thesis, University of Sheffield, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543950.
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Stock, Carolyn. "Beyond Romance's Utopia: The Individual and Human Love." The University of Waikato, 2007. http://hdl.handle.net/10289/2577.
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This thesis is a critique of romantic love theoretically premised on the analytical psychology of Carl Jung and the humanistic psychoanalysis of Erich Fromm. The aim of this critique is to explore whether there are grounds for postulating a conception of love beyond the current romantic framework. As the critique is primarily concentrated at the depth level, romantic love is examined via the medium of Cinderella folklore, with particular focus on Andy Tennant's 1998 film adaptation of Cinderella, Ever After. Based on a Jungian approach to the psyche and psychic products, the methodological framework incorporates the three following tools: The tool of interpretation at the subjective level, in which the characters of the Cinderella fairy tale are read symbolically rather than taken to denote literal fictitious characters; the tool of constructive analysis, in which it is argued that romantic love is more than 'nothing but' a boy/girl love story or 'nothing but' a myth depicting patriarchal oppression; and the tool of amplification, in which archetypal similarities between the Christian myth and the Cinderella fairy tale are highlighted. The central argument of this critique is that while romantic love does not provide a viable model of relatedness if taken and practiced literally, the romantic myth nonetheless contains within it the basis for a fuller and richer experience of love and relatedness if read subjectively. The rationale for a depth critique of romantic love is based upon the Jungian postulate that phenomena such as dreams and myths issue fundamentally from the unconscious psychic realm, and further upon Jung's recognition of a psychological developmental process he refers to as 'individuation' activated by engagement with the products of the unconscious. A symbolic/psychological reading of romantic love brings to light that romantic desire toward another is an outward manifestation of an inner desire for individual realisation, and is expressive of the individual's own capacity for wholeness. The value of a symbolic reading of romantic love is appreciated if it is conceived that it is precisely individual realisation that forms the basis for what is referred to by Erich Fromm as productive or knowledge-based love, argued here to be the ideal and only firm basis for human relatedness generally and intimate relatedness specifically.
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Yomafou, Adje hippolyte. "Face à l'angoisse du mal : propédeutique à une ontologie de la vie." Thesis, Paris Est, 2013. http://www.theses.fr/2013PEST0098.
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Au fil de notre voyage philosophique dans l'abîme de l'être-là de l'homme, il nous a été donné de constater que l'unique réaction qui a force de vérité et capable de maîtriser l'angoisse humaine devant la manifestation du mal, c'est le réflexe de la révolte. Cette révolte en la matière est une révolte contre la vie et contre l'auteur de cette vie. L'intelligence du mal y conduit inexorablement. Mais à quel prix ? Au prix d'une interdiction formelle demandant à Dieu de ne plus prendre pied avec l'humanité. Mieux faire le deuil de Dieu afin d'affirmer son moi souverain. Ce prix n'est pas négligeable, il est vertigineux pour l'homme. Il le propulse en un au-delà de lui-même. Tout lui semble permis désormais car il est le seul maître à bord du navire cosmique. Rien ne peut l'arrêter. N'étant plus soumis au pouvoir d'un Dieu suprême créateur, il peut faire tout car il a le dernier mot sur tout. Glorieuse liberté de l'homme ! Et pourtant cette liberté, cette puissance autonomique et pharaonique de l'homme aura révélé l'autre face tragique de la révolte. Une révolte qui aura conduit au pire mal absolu : le meurtre de son semblable. La mort a donc perdu de son caractère naturel, elle n'est plus un fait naturel et biologique, mais elle est devenue un fait imposé par l'homme à l'homme. Autrement dit, dans ce combat pour l'affirmation du moi, le plus grand vainqueur, le maître du monde, le maître absolu de demain, c'est la misère du monde. L'homme s'est révolté contre Dieu parce que l'injustice subie était incompatible avec l'idée d'un Dieu tout-puissant et bon ; ce Dieu a été mis de côté voire interdit de séjour sur la terre, mais la misère demeure. À l'évidence cette misère, plus puissante que la volonté même de l'homme, ne laisse aucune issue à l'homme. L'homme ne peut donc s'en tenir à la révolte contre la vie et contre Dieu, il lui faut une révolte contre la résignation face à cette misère. Cela suppose une révolte contre le désespoir. Désespérer contre toute désespérance. Sainte lucidité. Il n'y a pas d'autre moyen pour initier la sagesse humaine à cette révolte contre le désespoir que d'y entrer résolument dans la vie. Avoir confiance en la vie c'est - non pas comme cet optimisme qui voit dans cette misère une beauté et un bien pour l'homme – avoir le courage d'aimer cette vie. Aimer la vie c'est donner sens à son existence et au monde dans lequel se déploie cette vie. Cette attitude est responsabilité. Cette responsabilité est une chance pour l'homme lui-même et pour les autres. Par responsabilité, l'homme reçoit une nature qui fait qu'il diffère des autres étants et donc capable de dire « oui » ou « non ». Autrement dit, par sa responsabilité, l'homme accorde une valeur intrinsèque à la vie et à son existenceThroughout our philosophical journey into the depth of the existence of the human, it was given to us to see that the only reaction which has the force of truth and capable of controlling human anguish before the manifestation of evil is the reflex of the revolt . This revolt in this area is a revolt against life and against the author of this life. The intelligence of evil lead inexorably. But at what price? At the cost of a formal prohibition, asking God not to take up with humanity. Better to grieve of God to assert its sovereign me. This price is not negligible, it is breathtaking to human. He propels one beyond himself. How ever it seems possible now because it is the only master on board the cosmic ship. Nothing can stop it. No longer subject to the power of a supreme creator God , he can do anything because he has the last word on everything. Glorious liberty of man! Yet this freedom , this autonomic and pharaonic power of human has revealed another tragic face of the revolt . A revolt that has led to the worst absolute evil : killing one's fellow man. Death has lost its natural character, it is no longer a natural biological fact , but it has become a fact imposed by man to man.In other words, in this struggle for self-assertion , the biggest winner , the master of the world , the absolute master of tomorrow is the world's misery . Man rebelled himself against God because injustice is incompatible with the idea of an all- powerful and good God. That God has been set aside or banned from the earth , but misery remains . Clearly this misery , more powerful than even the will of human , leaves no end to human. The man can not stick to revolt against life and against God , it a revolt against the resignation to the misery it needs. This implies a revolt against despair. Despair against all despair. Holly saintly. There is no other way to initiate human wisdom in this revolt against the hopelessness to enter resolutely in life. Trusting life is - not as the optimism that sees misery as beauty and good for man to have the courage to love this life. Loving life is to give meaning to his life and the world in which this life unfolds . This attitude is responsibility. This responsibility is a chance for the man himself and others . Responsibility for , the man receives a nature that makes it different from other beings and therefore able to say "yes" or "no." In other words, by his responsibility, human gives an intrinsic value to life and existence
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Blanc, Nicolas. "Anthropologie et Providence dans l'Antiquité tardive : christianisme et philosophie chez Némésius d'Émèse." Thesis, Paris, EPHE, 2016. http://www.theses.fr/2016EPHE5087.
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Le De natura hominis de Némésius d’Émèse a surtout été étudié pour ses sources (Galien, Porphyre, Philopator) et pour son anthropologie. Il constitue pourtant l’un des apports les plus importants de la pensée chrétienne antique sur la question du destin, de l’autodétermination et de la providence, auquel ont notamment puisé Maxime le confesseur, Jean Damascène et Thomas d’Aquin. Notre étude a pour but de dégager la position de Némésius et son originalité au sein de la pensée patristique et face aux débats de la philosophie antique sur ces questions majeures. La première partie présente une contextualisation de l’œuvre et un status questionis sur sa datation, son plan, sa nature et ses destinataires, afin d’en dégager l’unité et la cohérence apologétique. La deuxième partie se propose, à travers la traduction commentée des chapitres 1 et 3, de manifester la logique interne du traité en relevant les éléments qui introduisent et préparent le traitement de la providence (place de l’homme au sein de l’univers, union de l’âme et du corps, ses origines et eschatologie). La troisième et dernière partie offre une traduction commentée des chapitres 35 à 43 spécifiquement consacrés au destin, à l’autodétermination et à la providence. De ces analyses, se dégage le profil d’une œuvre apologétique qui se distingue par la qualité de son approche philosophique, par la transcription au moyen de notions techniquement élaborées de l’idée chrétienne de la providence divine et par un intéressant développement sur la permission du mal et son sens dans le plan divinThe De natura hominis of Nemesius Emesa has principally been studied for its sources (Galen, Porphyry, Philopator) and its anthropology. However, it is one of the most important contributions of ancient Christian thought on the question of destiny, self-determination and Providence, inspiring Maximus the Confessor, John Damascene and Thomas Aquinas. Our study aims to identify Nemesius’ position and originality in patristic thought, and among the debates of ancient philosophy on these major issues. The first part presents a contextualization of the work and status questionis on the date it was written, its plan, its nature and recipients, in order to identify its unity and apologetical coherence. The second part proposes, through the translation and the Commentary of Chapters 1 and 3, to show the internal logic of the work, emphasizing the elements that introduce and prepare the treatment of Providence (the place of man in the universe, the union of soul and body, its origins and eschatology). The third and final part offers a translation and a Commentary of chapters 35 to 43, specifically devoted to fate, self-determination and Providence. From this analysis, there emerges the profile of an apologetic work that is distinguished by the quality of its philosophical approach, the transcription of the Christian idea of divine Providence through technically developed notions, and an interesting development on the permission of evil and its meaning in the divine plan
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Wee, Shiou-Liang. "Influence of the type of carbohydrate breakfasts on metabolism and endurance running capacity in man." Thesis, Loughborough University, 1999. https://dspace.lboro.ac.uk/2134/13775.
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Compared to the overnight fasted state, a high carbohydrate (CHO) breakfast 3-4 hours before exercise enhances endurance performance. However, the optimal type or composition of the pre-exercise meal to be consumed is less clear. Glycaemic and insulinaemic responses to a meal play a key role in subsequent metabolism during exercise. The investigations described in this thesis focused on the influence of I) the composition and 2) glycaemic index (GI) of CHO breakfasts 3 hours before exercise on postprandial and exercise metabolism and endurance running capacity.
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Lee, Shing-yip. "The ecology of a traditional tidal shrimp pond in Hong Kong, the production and fate of macrodetritus, and implications for management /." [Hong Kong : University of Hong Kong], 1988. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12430481.
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Gökçay, Didem. "Self-organizing features for regularized image standardization." [Gainesville, Fla.] : University of Florida, 2001. http://purl.fcla.edu/fcla/etd/ank7112.
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Thesis (Ph. D.)--University of Florida, 2001.Title from first page of PDF file. Document formatted into pages; contains ix, 117 p.; also contains graphics. Vita. Includes bibliographical references (p. 109-116).
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Edwards, Keith E. ""Putting my man face on" a grounded theory of college men's gender identity development /." College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/6862.
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Thesis (Ph. D.) -- University of Maryland, College Park, 2007.Thesis research directed by: Counseling and Personnel Services. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Quack, Gerd Christian [Verfasser], and Stephan [Akademischer Betreuer] Urban. "Targeting MAPK Signaling in Hepatocellular Carcinoma - Implications for Cell Fate, Microenvironment and Immune Recognition / Gerd Christian Quack ; Betreuer: Stephan Urban." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/117923023X/34.
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Maillols, Anne-Catherine. "La responsabilité du fait des médicaments : l'industrie pharmaceutique face à la loi du 19 mai 1998 /." Paris : Éd. de Santé, 2003. http://catalogue.bnf.fr/ark:/12148/cb391529761.
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Eimler, Sabrina C., Tina Ganster, and Nicole C. Krämer. "Als Chef hat man nichts zu lachen – Eine Studie zur Wirkung von durch Führungspersonen genutzten Emoticons in berufsbezogenen Emails." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-101077.
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1 Theoretische Vorüberlegungen
Im face-to-face (ftf) Kontext spielt das nonverbale Verhalten eine entscheidende Rolle bei der Wahrnehmung von Personen und der Interpretation des Gesagten [1,2]. Der Gesichtsausdruck [3], im Besonderen das Lächeln,nimmt in der interpersonalen Kommunikation eine essentielle Bedeutungein. So werden lächelnde Menschen in der Regel positiver, z.B.als glücklicher, höflicher und unbekümmerter, kompetenter und aufrichtiger beurteilt [4], allerdings auch als unterwürfiger [5,6]. Hinsichtlich der Bewertung von Männern und Frauen gibt es zudem stereotypbasierte Erwartungen an das Lächeln, die zu unterschiedlichen Bewertungen von Männern und Frauen bei gleichem Verhalten führen und in der Regel eine negative Bewertung von nicht lächelnden Frauen hervorrufen[7].
In der computervermittelten Kommunikation haben sich Smilies (Grafiken: J) und Emoticons (Zeichenketten wie :-)) mittlerweile als nonverbale, digitale Substitute für das Lächelnverbreitet, so dass auch im Netz sozusagen gelächelt werden kann. Verschiedene Studien untersuchten bisher die Wirkung von Smilies und Emoticons auf die Interpretation von Nachrichten und die Wahrnehmung des Smilienutzers. So kann zum Beispiel die Verwendung eines solchen Cues Zweideutigkeit reduzieren oder erzeugen, die Bedeutung einer Nachricht verstärken [8,9] oder aber die Stimmung des Lesers [10] und dessen Wahrnehmung vom Schreiber einer Nachricht [11] beeinflussen.
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Åström, Hedvig. ""the face of humanity can no longer be the face of one particular man" : Bidrag från en feministisk religionsfilosofi till det filosofiska samtalet om religiös mångfald." Thesis, Uppsala universitet, Teologiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-255532.
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Uppsatsen syfte är att undersöka mötet mellan feministisk religionsfilosofi och frågan om religiös mångfald. Utgångspunkten för uppsatsen är religionsfilosofiska texter av Pamela Sue Anderson och Grace Jantzen och dessa texter får här representera och ligga till grund för en feministisk religionsfilosofi. Som representant för det filosofiska samtalet om religiös mångfald använder jag mig av Mikael Stenmarks översikt över den typologi som präglar det filosofiska samtalet om religiös mångfald. Uppsatsens frågeställning lyder: Vad kan en feministisk religionsfilosofi som tar sin utgångspunkt i Grace Jantzens och Pamela Sue Andersons religionsfilosofiska texter bidra med till det filosofiska samtalet om religiös mångfald? Genom att läsa Andersons och Jantzens litteratur svarar jag för det första på hur en feministisk religionsfilosofi som tar sin utgångspunkt i Andersons och Jantzens texter skulle kunna se ut. För det andra undersöker jag hur en feministisk religionsfilosofi förhåller sig till det filosofiska samtalets typologi (exklusivism, inklusivism och pluralism) vad gäller religiös mångfald. Slutligen svarar jag på vad en feministisk religionsfilosofi kan bidra med till det filosofiska samtalet om religiös mångfald. Ett första bidrag kan innebära en medvetenhet och erfarenhet om mångfalden som finns ibland oss. Ett andra bidrag kan innebära en diskurskritik och en medvetenhet av att religionen inte går att separera från samhälleliga normer och diskurser. Ett tredje bidrag kan handla om fantasi och föreställningsförmåga som strategi. På grund av globalisering, migration och kommunikation som snabbt tar oss över jordklotet uppstår möten mellan människor med olika erfarenheter, traditioner, kulturer och religioner. Detta innebär nya utmaningar som inte bör lösas genom att dela in människor i påstått homogena grupper och försöka lösa konflikter och oenighet mellan dessa grupper. Den feministiska religionsfilosofin med dess utmaningar - att granska maktstrukturer, söka alternativa bilder och våga göra nya tolkningar av religioners funktioner och betydelser i ljuset av feministisk teori - riktar blicken mot mellanmänskliga relationer, oavsett religionstillhörighet.
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Rousseau, Clément. "Concevoir une stratégie de défense face aux comportements égoïstes de noeuds utilisant le protocole MAC IEEE 802.11." Mémoire, École de technologie supérieure, 2011. http://espace.etsmtl.ca/912/1/ROUSSEAU_Cl%C3%A9ment.pdf.
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La coopération de l’ensemble des noeuds d’un réseau ad-hoc permet de garantir le
fonctionnement optimal de celui-ci. Un noeud peut toutefois avoir un comportement égoïste
au niveau de la sous-couche MAC du protocole IEEE 802.11 qui gère le contrôle de l’accès
au médium. Ce comportement égoïste peut se traduire par une diminution de la taille de la
fenêtre de contention afin d’augmenter la priorité d’émission. La conséquence d’un tel
comportement pour un noeud est une amélioration de sa capacité d’émission, de son débit,
entrainant une dégradation de la bande passante de l’ensemble du réseau.
Dans cette étude nous concevons une stratégie de défense basée sur la stratégie Tit-for-Tat
(TFT), développée en théorie des jeux pour faire face à ces comportements égoïstes. Nous
démontrerons pourquoi et comment une telle stratégie vise à obtenir l’équité dans le partage
de la bande passante. Nous introduirons des variantes de TFT comme un Tit-for-Tat
généreux (GTFT), où l’introduction d’un facteur de générosité va permettre de s’adapter aux
contraintes du médium. Enfin nous discuterons du choix et de l’influence des paramètres
d’une telle stratégie sur le comportement d’un noeud et du réseau.
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Costa, Jamilly de Souza. "Densidade de estocagem em camar?es da esp?cie Macrobrachium rosenbergii (De Man, 1879) na fase juvenil." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br/handle/123456789/19433.
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Entre as diversas atividades aqu?colas, a carcinicultura sobressai-se devido ao alto valor comercial que os crust?ceos atingiram no mercado. Dentre as esp?cies de ?gua doce cultivadas, uma das que mais t?m se destacado ? Macrobrachium rosenbergii. O conhecimento sobre o comportamento da esp?cie e a influ?ncia das caracter?sticas do ambiente em seu desenvolvimento pode otimizar o manejo e minimizar prov?veis impactos ao meio ambiente e ao pr?prio animal. Assim, nosso objetivo geral foi caracterizar as atividades comportamentais dessa esp?cie nos est?gios iniciais do desenvolvimento em diferentes densidades de estocagem, nas fases do ciclo de luz. P?s-larvas com 30 dias de vida foram trazidas da Escola Agr?cola de Jundia? (EAJ), Maca?ba/RN e, em seguida, transferidas para o laborat?rio de Estudos do Comportamento do Camar?o (LECC), da Universidade Federal do Rio Grande do Norte (UFRN), onde foram medidas e pesadas. Para cada experimento, foram utilizados oito aqu?rios de 60 L (40 cm x 30 cm x 50 cm), com temperatura e aera??o constantes e filtra??o cont?nua atrav?s de m?dias filtrantes biol?gicas em mini-tubos, areia, l? de vidro e carv?o vegetal, contendo tr?s cent?metros de areia de filtro de piscina (granulometria m?dia) como substrato e submetidos ao ciclo de 12h/12h, tendo 30% da ?gua trocada uma vez por semana. Os abrigos utilizados foram peda?os de tijolos, sendo 2 em cada aqu?rio. A qualidade da ?gua foi monitorada semanalmente. Para observa??o do comportamento dos animais, utilizamos duas densidades: 25 animais m-? e 40 animais m-?. Os comportamentos foram observados atrav?s dos seguintes m?todos de registro: amostragem comportamental - entrada e sa?da do abrigo, coleta de alimento no substrato e na coluna d??gua, afastamento, ataque, persegui??o e canibalismo; scan - inatividade, alimenta??o, explora??o, cava??o, nata??o, limpeza e perman?ncia no abrigo. As observa??es ocorreram em janelas de 15 minutos/aqu?rio, 4 vezes ao dia, por 4 dias na semana, ao longo de 4 semanas. O alimento foi ofertado 2 vezes ao dia, imediatamente antes de 2? e da 4? janela de observa??o de cada aqu?rio. Nossos resultados demonstraram que na alta densidade, na fase de claro, os animais apresentaram maior frequ?ncia de atividades comportamentais que possivelmente promoveram menor exposi??o, e tamb?m evita??o de atos agon?sticos. Nessa densidade, na fase de escuro, a maior frequ?ncia foi de comportamentos que pareceram gerar maior exposi??o a riscos. Para a baixa densidade, encontramos um padr?o que pode ser importante para o manejo ao gerar mais conforto aos animais no ambiente de cultivo. Concluiu-se que a densidade de estocagem exerceu influ?ncia na express?o das atividades comportamentais de M. rosenbergii nos est?gios iniciais do desenvolvimento, com modifica??es no comportamento que indicam bem-estar pobre ao animal em condi??es de alta densidade de estocagem.
Among the species of freshwater shrimp being cultivated, Macrobrachium rosenbergii stands out. Knowledge about the behavior of this species and the influence of certain factors on its development can help optimize management practices and minimize the likely impacts shrimp farming has on the environment and the animals themselves. The objective of this study was to characterize the species' behavior during early stages of development under different stocking densities over a 24-hour cycle. Ten day old postlarvae were transferred from the Jundia? School of Agriculture (EAJ - Escola Agr?cola de Jundia?) in Maca?ba (RN), Brazil to the Shrimp Behavior Laboratory (LSPR - Laborat?rio de Estudos do Comportamento do Camar?o) at the Federal University of Rio Grande do Norte (UFRN), where they were weighed and measured. Eight aquaria with constant temperature, aeration and filtration, and subjected to a12 h light/12 h dark cycle were used for each experiment. Each aquarium also contained two shelters made of bricks and the water quality was monitored weekly. Behavioral observations were made at two densities: 25 individuals/m-? and 40 individuals/m-?. The methods for recording behaviors were: behavioral sampling ? enter and leave the shelter, exploring on the substrate, exploring in the water column, move away, attack, pursuit and cannibalism; scan sampling - inactivity, feeding, exploration, digging, swimming, cleaning and staying in the shelter. Observations were made during a 15 minute period/per aquarium at a frequency of 4 times daily, for 4 days/week, and over 4 weeks. Food was provided 2 times/day for each aquarium population, immediately before the 1st and 3rd observation periods. Our results demonstrate that at high density, there is an increased frequency of agonistic behavior; during the light phase, there is a greater frequency of behaviors that result in less exposure (inactivity, cleaning and staying in the shelter); during the dark phase, there is an increased frequency of behaviors that result in greater exposure (feeding, exploration, swimming and digging); at times of feed offer, there is an increased frequency of leaving the shelter, moving away, pursuit, feeding, exploration and swimming. At low density, the animals showed a lower frequency of agonistic behaviors, greater weight gain and higher growth rates, which indicates that this is a more favorable growing environment for cultivation and when applied, can generate better living conditions, favor survival rates and increase management success
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Gerth, Klaus Erich. "La grande presse quotidienne néerlandaise face à la politique hitlérienne du 30 janvier 1933 au 10 mai 1940." Lille 3 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37597836z.
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DIEDLER, PASCAL Grilliat Jean-Pierre. "LE MAL DONNE FACE A LA MEDECINE LES PATHOLOGIES DITES MALEFIQUES EN LORRAINE DU SUD (XVIEME - XVIIEME SIECLES) /." [S.l.] : [s.n.], 2001. http://www.scd.uhp-nancy.fr/docnum/SCDMED_T_2001_DIEDLER_PASCAL.pdf.
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Miranda, Margarete Parreira. "O mal-estar do professor em face da criança considerada problema: um estudo de psicanálise aplicada à educação." Universidade Federal de Minas Gerais, 2010. http://hdl.handle.net/1843/FAEC-87BQPY.
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En élisant comme objet de nos études le malaise de lenseignant face à lenfant considéré problème, nous entendons dégager de ce contexte des connaissances qui soient en mesure daccroître la marge dentendement et dinterférer dans ce qui ne va pas dans le cadre du rapport enseignant-élève-apprentissage. Nous formulons lhypothèse selon laquelle lenfant est considéré comme un problème au moment où le professeur se voit destitué de sa fonction denseigner. Des enseignants denfants de sept à onze ans, de trois écoles publiques municipales de la ville de Belo Horizonte, ont été choisis comme sujets de notre recherche. Dans nos études théoriques, nous avons constaté que les investigations à propos du malaise des enseignants ont été de plus en plus nombreuses sur les vingt dernières années, dans plusieurs pays du monde occidental. Nous vérifions également que lenfant est considéré comme un problème depuis la première moitié du XXème siècle jusquà nos jours, ce nest que laspect extérieur de la présentation de ce symptôme qui prend des tournures différentes. En adoptant comme méthodologie de terrain les Conversations, un dispositif de la psychanalyse appliquée à léducation, nous misons sur les effets dune recherche- intervention qui a pour principe dinterférer sur les discours cristalisés et de promouvoir des déplacements et des transformations sur les discours et sur les actes des enseignants. Nous avons pu identifier, lors de nos investigations, le circuit du discours qui renforce léchec, aussi bien quun autre côté, celui de la transmission possible. Dans le sens contraire du discours de la science qui ségrègue la subjectivité, la psychanalyse appliquée à léducation peut contribuer pour que le sujet ne tourne pas le dos aux propositions civilisatoires et puisse trouver dans lécole un lieu où tisser des liens sociaux.Ao elegermos como objeto de nossos estudos o mal-estar do professor em face da criança considerada problema, objetivamos extrair desse contexto conhecimentos que pudessem estender a margem de entendimento e interferir no que fracassa na relação professor-aluno-aprendizagem. Formulamos a hipótese de que a criança é considerada problema no momento em que o professor se vê destituído de sua função de ensinar. Os professores de crianças de sete a onze anos, de três escolas públicas municipais da cidade de Belo Horizonte, foram escolhidos como sujeitos de nossa pesquisa. Em nossos estudos teóricos, constatamos que as investigações sobre o mal-estar dos professores se avolumaram nos últimos vinte anos, em vários países do mundo ocidental. Averiguamos também que a criança é considerada problema desde a primeira metade do século XX até os nossos dias, alterando-se apenas a roupagem da apresentação desse sintoma. Ao adotarmos como metodologia de campo as Conversações, dispositivo da psicanálise aplicada à educação, apostamos nos efeitos de uma pesquisa-intervenção que tem como princípio interferir nos discursos cristalizados e promover deslocamentos e transformações no dizer e no fazer dos professores. Foi possível identificar, em nossas investigações, o circuito do discurso que reforça o fracasso, assim como o outro viés, o da transmissão possível. Na contramão do discurso da ciência que segrega a subjetividade, a psicanálise aplicada à educação pode contribuir para que o sujeito não se aliene das propostas civilizatórias e possa encontrar na escola um lugar de enlaçamento social.
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Gerth, Klaus Erich. "La grande presse quotidienne néerlandaise face à la politique hitlérienne : (du 30 janvier 1933 au 10 mai 1940)." Paris 4, 1985. http://www.theses.fr/1986PA040259.
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Ce travail expose les similitudes et les différences entre les situations historiques de l'Allemagne et des Pays-Bas avant la deuxième guerre mondiale. Il analyse l'attitude des grands quotidiens néerlandais face au nazisme de 1933 à 1940. Vis-a-vis d'Hitler, la presse neerlandaise des années trente a eu un mouvement de rejet quasi unanime. Il y a eu, cependant, des cheminements d'idées liant les principales familles de pensée néerlandaises au nazisme allemand comme au fascisme italien. Ces dérapages en faveur du nazisme se produisirent surtout en 1933 à l'occasion d'évènements d'actualité particulièrement significatifs. Cependant, dans l'ensemble, la presse néerlandaise a très bien assuré sa mission d'information et d'éveil des consciences dans une période de mutation profonde, à l'aube de la communication de masseThis study attempts to show the similarities and differences between the historical situation in Germany and Netherlands before the second world war. It analyses the attitude of the most important Dutch newspapers in front of nazism from 1933 to 1940. In the thirties, the Dutch press had an almost unanimous movement of rejection towards hitler. However, there were some processes of ideas linking the main Dutch families of thoutht to german nazism as well as to italian fascism. Those side-slips toward nazism especially took place in 1933 on the occasion of particularly significant passing events. Yet, on the whole, the Dutch press very well carried out its mission of information and awakening of consciences in a time of deep change at break of the era of mass communication
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Mastrovito, Mirco. "User reputation and data quality in a crowdsensing platform for impaired mobility." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
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This dissertation project aims to deal with all these problems by proposing a platform to support people with reduced mobility. There are systems that deal with the problem of urban accessibility through sets of data provided by certified authorities. Such systems have the limit of not being updated in real time and do not extend the possibility of adding information to all participants. From this comes the idea of creating a new application. The application purpose is to collect information on urban accessibility from all users and guarantee, by applying the
concept of crowd-sensing, a high level of data trustworthiness. To be effective in its goal, the application must be easy to use and accessible to everyone at anytime and anywhere. For this reason, the software will be developed around two must-haves that form the main basis for today's communication: Internet and smartphones.
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Duverlie, Dominique. "Les Picards face à l'occupation allemande : le département de la Somme du 20 mai 1940 au 3 septembre 1944 /." [Amiens] : Bibliothèque municipale d'Amiens, 2004. http://catalogue.bnf.fr/ark:/12148/cb39216688h.
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Bordelais, Gareth Hatzfeld Nicolas Loubet Jean-Louis. "Le fonctionnaire de police face aux évenements de mai 68 au sein de la préfecture de police de Paris." [S.l.] : [S.n.], 2006. http://www.biblio.univ-evry.fr/memoires/2006/2006_MM2_Histoire_Bordelais.pdf.
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VOLICH, EISENBRUCH RENATA. "La pathologie organique : mal enigmatique face a la jouissance et au desir de la mere - une clinique de l'angoisse." Paris 7, 1998. http://www.theses.fr/1998PA070069.
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These clinique articulee autour des points d'inflexion de la cure psychanalytique. Ces points sont, entre autres, la levee du symptome et la traversee du fantasme. Cet ouvrage se presente sous la forme de quatre chapitres suivis d'une bibliographie concernant 39 auteurs et reunissant 120 livres ou articles. Le symptome en tant que formation de l'inconscient et le fantasme du point de vue de la verification clinique sont articules par rapport a la problematique inconsciente de l'autre maternel faisant irruption dans le reel du corps de l'enfant par l'effet d'une jouissance deletere qui est la pathologie organique. Le champ balise, le choix se trouve justifie par le terrain clinique a partir duquel l'auteur soumet ses options methodologiques et ses objectifs theoriques aux imperatifs de la cure. Le premier chapitre illustre l'incidence pathogene du fantasme, analysant l'eclosion d'une symptomatologie organique d'asthme infantile. Un deuxieme chapitre intitule + de l'irreductibilite du trauma a l'implication du sujet dans le desir ; expose le cas des lesions amenant le sujet a subir une hysterectomie. Le chapitre suivant consacre a l'intrication du symptome et du fantasme trouve son parallele clinique dans le cas de cecite au cambodge. Une approche des crises d'epilepsie est exposee dans le dernier chapitre qui est consacre a la definition de ce que l'auteur cerne comme + une clinique de l'angoisse ; cette derniere constituant + une dimension non preventive du symptome ;. Fonction mediane entre la jouissance et le desir l'angoisse peut jouer un role operatoire dans la cure analytique. Cette approche d'un au dela de la limite de l'angoisse justifie les hypotheses cliniques qui sous-tendent le travail propose. Cette recherche vise apporter, dans une perspective rigoureusement circonscrite a la clinique psychanalytique, un instrument qui mette au travail un concept capital de l'etre a la croisee d'une clinique des affects et d'une clinique des reppresentationsThis thesis is presented as a volume of 416 pages divided in four chapters followed by a bibliography encompassing 39 authors and assembling 120 books or articles. As a clinical thesis it is articulated around the symptom as a formation of the unconscious and the phantasy from the point of view of the clinical verification. These aspects are articulated to the unconscious question of the maternal other making irruption in the the child's body by the effect of a deleterious source of an unconscious satisfaction that the organic pathology can represent. Having demarcated her area, the choice is justified by the clinical field from which the author submits her methodological choices and her theoretical objectives to the imperatives of the treatment. In the first chapter the pathogenic impact of the phantasy through the irruption of an organic symptomatology of an infantile asthma is illustrated. The second chapter entitled + from the irreducible of the trauma to the implication of the subject in the desire ; presents the case of lesions leading the subject to undergo an hysterectomy. The following chapter is consecrated to the intricacy of the symptom and the phantasy finding its clinical counterpoint in the case of blindness in cambodia. An approach of epileptic seizures is presented in the last chapter dedicated to the definition of what the author defines as + a clinic of anguish ; the latter constituting + a non preventive dimension of the symptom ;. An intermediate function between "jouissance" and desire, anguish can play an operational role in the treatment. This approach of going beyond the limit of the anguish justifies the clinical hypotheses underlying the proposed work. This thesis aims to bring - in a perspective rigorously circumscribed to the psychoanalytical clinic - an instrument that puts at work a fundamental concept of the human being at the crossing of a clinic of affects such as the anguish and a clinic of representations
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Desombre, Laurent. "Fiabilité et modélisation cognitive de l'opérateur humain face à des signaux visuo-posturaux." Valenciennes, 1997. https://ged.uphf.fr/nuxeo/site/esupversions/a9fc578f-b8df-4eab-b503-cedffac16912.
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Le travail présenté dans ce mémoire entre dans le cadre d'un contrat de recherche établi entre la direction de la recherche et de la technologie (division ergonomie - ministère de la défense) et le laboratoire d'automatique et de mécanique industrielles et humaines. L'évolution des systèmes vers une automatisation de plus en plus poussée conduit très souvent à transformer l'activité humaine dans les moyens de transport par air, mer ou terre, en une activité de surveillance et de contrôle d'interface graphique assurant les interactions homme-machine. La monotonie de la tâche qui en résulte associée aux contraintes caractérisant les conditions de travail, ont des effets négatifs sur la vigilance et la performance des opérateurs humains et plus généralement sur la sécurité des systèmes. Aussi convient-il d'analyser les caractéristiques de la situation de travail et de l'operateur pour répondre à un besoin double d'analyse fiabiliste et de modélisation du comportement humain en régime perturbé ou face à une situation accidentelle. Les travaux résumés dans ce mémoire visent à poursuivre l'exploration des perturbations temporaires affectant le fonctionnement des opérateurs, perturbations liées ici aux contraintes temporelle, visuelle et posturale de la situation de travail. Ils englobent à la fois des travaux sur les stimulations vestibulaires d'origine vibratoire et des études sur la présentation d'informations visuelles sur écran graphique, et sont abordés dans une perspective pluridisciplinaire, conciliant aspects humains et automatiques. La situation analysée est celle d'un opérateur humain effectuant une tache de catégorisation de signaux visuels, de durée limitée et de nature simple et répétitive ; sa complexité réside dans la part de réflexion nécessaire à la discrimination de ces messages en fonction de critères définis à l'avance. Au point de vue méthodologie, les données sont traitées dans le cadre de la théorie de la détection du signal dont la principale originalité est d'isoler dans l'acte perceptif, le processus décisionnel du processus sensoriel. Dans ce cadre théorique, trois expérimentations ont été réalisées. La mise en place d'un dispositif d'évaluation des performances perceptives et cognitives de l'opérateur humain effectuant une prise de décision, a fait l'objet de la première expérimentation. Au cours de la deuxième expérimentation, la charge de travail et la capacité perceptive et cognitive de l'opérateur humain sont analysées dans l'environnement vibratoire d'un voilier dans diverses conditions de navigation rencontrées au cours de l'expédition de celui-ci dans l'antarctique. Les taches visuo-cognitivo-motrices de l'opérateur humain pendant ces deux séries d'expériences ont été réalisées avec un temps imposé fixe qui est modulé dans la troisième expérimentation. Dans celle-ci et dernière expérimentation, le rôle et les effets des modifications de la pression temporelle, des faibles variations d'amplitude des stimuli graphiques et des stimulations vestibulaires d'origine vibratoire, sont examinés sur les performances de l'opérateur humain effectuant une tache de détection de variation de figures graphiques. L'analyse des données recueillies tout au long de la phase expérimentale, fait appel dans une première approche à une méthodologie d'évaluation basée sur un modèle statistique, dont la structure est l'analyse Bayesienne des comparaisons. Ce choix est directement suggéré par la mesure de l'activité de l'homme. L'autre approche est plus globale car elle permet de tenir compte du caractère multivariable du comportement humain. La technique d'analyse de données est alors multidimensionnelle : analyse en composantes principales. Finalement, une tentative de modélisation des phénomènes observés dans l'environnement visuo-postural étudié et une identification des lois expérimentales obtenues permettent d'interpréter les résultats et de les présenter sous la forme de modèles. La mise en œuvre de ces modèles fait l'objet de la dernière partie de ce mémoire. L'originalité réside alors dans l'analyse des raisonnements, représentations mentales et mécanismes automatiques liés aux diverses prises de décisions affectées par un jeu de contraintes (délai, difficulté d'observation, stimulations vestibulaires) s'exerçant sur l'opérateur humain.
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Cifuentes, Medina Flor María del Pilar. "Le mal-être dans le deuil : la place de l’art face à la précarité des rites dans les sociétés contemporaines." Paris 8, 2012. http://octaviana.fr/document/16873298X#?c=0&m=0&s=0&cv=0.
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Dans le rite traditionnel c’était l’acte propitiatoire qui fonctionnait comme moteur de la dynamique entre pulsion de vie et pulsion de mort, mais dans les sociétés contemporaines en Occident cet acte propitiatoire n’a plus de sens. Ainsi, il ne reste au sujet que l’acte créateur, mais dans sa version individualisée et dont le noyau intrapsychique semble coïncider avec l’introversion moderne du deuil. Cette incapacité du sujet moderne à donner une place à ses morts au-delà de soi s’exprime dans son œuvre, qui devient ainsi un appel au social, à cette extériorité nécessaire au processus de deuil. Notre étude essaye de situer, à partir d’une étude de cas, les relations structurelles qui existent entre les mécanismes du deuil et le processus créateur, et de relever l’importance de l’acte créateur en tant que dispositif de cohésion sociale et de soutien symbolique au deuilleur. Nous montrons ici comment les manifestations plastiques du deuil permettent au deuilleur de se construire comme sujet après la perte. Le passage par le contact direct, intime avec la matière, le temps employé pour l’élaboration de l’œuvre ainsi que la parole qu’elle véhicule, font partie intégrante du dispositif de deuil agencé par le deuilleur. L’artiste nous offre ainsi la possibilité de partager avec lui ce qu’il a appris par le biais de son deuil dans l’acte de création ; il nous renvoie son savoir à propos de la mort, un savoir qui ne lui a pas été transmis, un savoir par lequel il nous ouvre une porte, mais à condition que nous soyons prêts à partager sa déchirure, qui est la nôtre aussi, même si nous avons perdu la capacité de la reconnaîtreIn traditional rite it was the propitiatory act which functioned like the dynamics between the death instinct and the life instinct, but in the contemporary societies in Western societies this propitiatory act does not make sense anymore. Thus, that is left to subject is only the creative act, but in its individualized version and whose intrapsychic core seems to coincide with the modern introversion of mourning. This incapacity of the modern subject to give a place to death apart from oneself is expressed in his work, which becomes a call to society, to this exteriority necessary to the process of mourning. Our study tries to place, with a case study, the structural relations which exist between the mechanisms of mourning and the creative process, and to record the importance of the creative act as a device of social cohesion and symbolic support for the bereaved. We show here how the plastic representations of mourning allow the bereaved to build themselves as subject after the loss. The passage by direct and intimate contact with the material, the time employed to the elaboration of work as well as the word which it conveys, are an integral part of the dispositive of mourning arranged by the bereaved. So the artist offers us the possibility of sharing with him what he learnt in the act of creation thanks to mourning; he returns us his knowledge about death, a knowledge that was not transmitted, a knowledge thanks to which he opens a door to us, but provided we are ready to share his wound, which is also ours, even if we have lost the capacity to recognize it
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Sango, Sophie. "Le "roman confession" au XIXe siècle." Thesis, Toulouse 2, 2015. http://www.theses.fr/2015TOU20025.
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Certaines fictions romanesques du XIXe siècle se présentent sous la forme de récits rétrospectifs faits à la première personne par un narrateur qui propose une relecture de son passé. Ce retour en arrière peut prendre la forme d’une confession. Dans quel but la confession investit-elle le roman ? Pourquoi la confession passe-t-elle par l’intermédiaire d’une fiction ? L’analyse met en évidence l’émergence d’un nouveau genre dans l’histoire littéraire – le « roman confession » –, genre historiquement daté qui a ses propres règles, ses propres critères, sa propre logique, et qui se situe au confluent de deux genres singuliers : l’autobiographie et le romanIn literature, confessions can be inserted into novels. Confessions belong to the autobiographical genre and can show faults, sins and guilty behavior whereas novels belong to the fictional genre. Our work analyses the extent to which a new genre appears in the literary history, and most particularly in the 19th century. Indeed, the “novel confession” is a genre of the 19th century, with its own characteristics
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Lopes, Maria de Fátima Triguinho. "Do mal ao banal: Uma interpretação do discurso social sobre a SIDA." Master's thesis, Instituto Superior de Psicologia Aplicada, 2001. http://hdl.handle.net/10400.12/611.
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Dissertação de mestrado em Psicopatologia e Psicologia ClínicaSerá que um mal passou a banal, foi a questão de partida para analisarmos diferentes perspectivas sociais sobre a SIDA, doença que coloca um amplo espectro de inquietações, mas com a qual convivemos já quase pacificamente. Esta dissertação procura encontrar nos discursos sociais sobre a doença, em particular nos discursos religioso, científico e psicológico, a evolução do pensamento social, bem como as invariantes que lhe são próprias. A metodologia utilizada fundamenta-se na teoria psicanalítica como procura de compreensão de um facto social, seguindo os passos da análise de conteúdo. Começamos por abordar o significado psicológico da doença para nos centrarmos na temática da SIDA, numa breve história, caracterização e seu significado no plano individual e social. Na triangulação teórica Freud, Melanie Klein e Bion, desenvolvemos os fundamentos conceptuais que servem de base à nossa interpretação. Com Freud retomámos os aspectos essenciais do narcisismo e da fragilidade narcísica. Seguidamente com Klein revisitámos os conceitos de ansiedade paranóide / depressiva, clivagem e identificação projectiva. Por último, com Bion seguimos as particularidades da sua teoria dos grupos. O último capítulo constitui o nosso objecto de reflexão. Refere-se à interpretação dos artigos de jornal, publicados no período compreendido entre 1990 e 1999, que nos foram facultados pela Comissão Nacional de Luta Contra a SIDA. Os textos foram sistematizados nos três discursos base: psicológico, cientifico e religioso, constituindo cada um deles uma categoria da nossa análise. Seleccionadas as expressões significativas, procedemos à sua análise elegendo em cada um dos discursos, as invariantes interpretativas (as sub-categorias). A sistematização dos dados obtidos mostra a evolução das atitudes sociais face à SIDA ao longo dos anos em estudo e são sobretudo reflexo da reprodução de um discurso que se mantém quase imutável em cada um deles. A reflexão crítica, permite-nos afirmar que as inferências feitas são plenamente justificadas à luz dos conceitos interpretativos que seguimos. De facto, o "racional" do discurso científico, onde as sub-categorias dominantes são o conhecimento e limitação, parece não saber lidar com o irracional, ou seja, o lugar aonde o limite (científico) se gera é o mesmo onde o fantasma se produz. Já o discurso religioso se paradoxaliza face à SIDA, pois ao mesmo tempo que culpabiliza procura a integração e o cuidado ao doente. O discurso produzido ou é de negação (desmentido da realidade), ou de triunfo e/ou desprezo sobre a própria realidade. Quanto ao discurso psicológico, dominando a fragilidade narcísica, revela-nos que nem o cientismo dominante consegue iludir os problemas próprios à espécie humana (a dor mental, o desamparo). Por outro lado, o predomínio de ansiedades confusionais nos sujeitos com SIDA não surpreende, uma vez que o lugar do sujeito desejante é radicalmente o mesmo onde se condena à morte.
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Bessou, Anne-Line. ""Faire face(s)" au travail : entre stress et pression sociale dans le monde du travail, le corps à l'épreuve du regard photographique." Thesis, Toulouse 2, 2013. http://www.theses.fr/2013TOU20065.
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La thèse en Arts plastiques que nous proposons associe une pratique artistique personnelle de photographie et une recherche à la croisée des sciences de l’art, de la sociologie et de la psychologie. Elle développe une analyse de la représentation du travail dans l’art à travers l’utilisation du médium photographique, du début du 20ème siècle à aujourd’hui, avec un intérêt particulier pour l’extrême contemporain. L’enjeu principal de cette recherche est de démontrer comment une pratique artistique peut traduire un fait d’actualité pourtant peu visible, ici lié à la représentation sociale du travail. Elle se focalise sur un exemple précis, celui du mal-être au travail, qui fait l’objet à la fois de la pratique artistique personnelle et de la recherche proposée. Que ce soit par une expérimentation du portrait ou par l’élaboration de mises en scène, les choix plastiques de cette représentation amènent à s’interroger sur les caractéristiques et la production de sens d’un dispositif de création qui allie théâtre vivant et images fixes assemblées en polyptyques – tout en suscitant la réflexion sur un problème humain devenu un phénomène sociétalThe thesis in Arts that we present associates a personal artistic practice of photography and a research at the crossing of arts sciences, sociology and psychology. It develops an analysis of the representation of work in arts through the use of the photographic medium, from the beginning of the 20th century until today, with a particular interest in the extreme contemporary period. The main stake of this research is to demonstrate how an artistic practice can translate a current event with little visibility, linked to the social representation of work. It focuses on a specific example, the malaise at work, which is the object of both the personal artistic practice and the research work. Whether by the use of portrait or by a staging work, the choices of this artistic representation interrogate the characteristics and the production of meaning of a creative device which combines theatre and still images assembled in polyptyches – while inciting reflexion on a human problem that has become a social phenomenon
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Burtin, Nicolas. "Vulnérabilité sociale et relation homme/animal : les structures d'accueil despopulations vulnérables en Rhône-Alpes face à la question de l'animal de compagnie." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAH028.
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Dans un contexte de prise en compte grandissante des « non humain » en général et des animaux de façon plus spécifique au sein des sciences sociales, la présente thèse interroge les relations entre des publics fragiles et leurs animaux, et ce, notamment lorsque ces publics sont amenés à entrer dans des établissements médicaux-sociaux. Si les animaux de compagnie font partie de nos vies, ceux-ci demeurent toutefois encore peu présents dans les établissements où peuvent séjourner des propriétaires d'animaux. Dès lors, que font ces propriétaires lorsque l'établissement n'accueille pas l'animal de compagnie ? Quelle place occupe ce dernier durant cette période de l'existence où le propriétaire peut ou doit faire son entrée dans un établissement ? Cette thèse met d'abord en évidence la façon avec laquelle l'attention portée aux « relations humanimales », initialement peu présente dans nos disciplines, s'est développée à partir de la fin du XXe siècle. Après ces premiers pas théoriques, nous cherchons à rendre compte des spécificités non seulement de la perception mais également de la relation qu'ont les publics fragiles (hommes « sans-domicile » et personnes âgées) avec l'animal de compagnie. La dernière partie de la thèse propose un état des lieux de l'accueil de l'animal de compagnie au sein des structures d'hébergement pour « sans domicile » et des établissements pour personnes âgées, sur le territoire de la région Rhône-AlpesIn a context of growing consideration for "nonhumans", in general, and animals, more specifically, in the social sciences, this thesis examines the relationships between vulnerable audiences and their pets, mainly when these audiences are to enter shelter-based healthcare facilities. While pets form an integral part of vulnerable people lives, they are usually not accepted in these facilities, even when pet owner are allowed to live there. What do these owners do when a facility does not welcome their pets? What happens with pets when the owner can or must enter such a facility? This thesis first highlights the way in which the attention paid to "human-imal relationships", initially sporadic in our disciplines, has gained momentum since the end of the 20th century. After this first theoretical step, we seek to account for the specificities not only of the perception but also of the relationship that vulnerable audiences ("homeless" men and elderly people) have with their pets. The last part of the thesis proposes a shelter for pets to be built within the facilities for "homeless" and elderly people in the region Rhône-Alpes
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Tauty, Anne-Charlotte. "Penser le mal moral, une généalogie de la volonté moderne." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE3046/document.
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Le mal est par sa nature un scandale car il se définit par ce qui ne devrait pas être à l’opposé du bien qui se présente comme ce qui doit être. Cette affirmation, qui relève de la tautologie, marque la réalité éprouvée face au mal. Il a d’abord été une évidence criante : comment réagir face aux maux de l’existence humaine ? Ainsi le mal est inscrit dans l’histoire de la pensée et commence pour notre travail avec le platonisme. Avant la conceptualisation platonicienne, le mal est une donnée factuelle de la vie avec laquelle il faut composer. Les figures divines sont ambivalentes à l’image des hommes et alternent vices et vertus. Platon postule une entité divine unique, omnisciente, omnipotente et bienveillante. Ce dieu devient intelligence, calcul et raison : le monde devient une création parfaite, belle et ordonnée et non plus le théâtre d’un affrontement entre les diverses passions des dieux. Le mal se transforme alors en un enjeu métaphysique : comment concilier cette perfection avec l’émergence du mal ? Il faut désormais expliquer et tenter de justifier la violence et les crimes. S’il est possible de proposer une théodicée qui rende le mal physique et métaphysique nécessaire, légitimer la méchanceté se révèle plus ardu. Les penseurs du platonisme, du néoplatonisme et du stoïcisme vont tenter d’apporter une première réponse au mal moral. Dans leur sillage, une rupture conceptuelle advient et révolutionne le concept : le christianisme invente le péché. En devenant péché, le mal se retrouve désormais sous la responsabilité de l’homme coupable. Le mal entre dans le giron de la liberté : il est voulu, consenti. A la suite des penseurs chrétiens, certains philosophes continueront ce travail d’élucidation de la volonté du mal. L’objectif est de retracer l’histoire de ces systèmes conceptuels qui s’entremêlent et se répondent les uns aux autres. Le mal moral se construit dans cette progression qui a des conséquences anthropologiques importantes : l’homme se pense à travers le mal. La méchanceté n’est donc pas seulement un problème à résoudre, elle devient le paradigme à travers lequel définir l’homme. Notre problématique est de montrer comment la question de la méchanceté est à la base du problème de la morale et comment elle conditionne notre représentation de la nature de la volonté humaine. Cette évolution s’est nouée lors d’étapes clés de la pensée philosophique. En effet, si dans toute philosophie morale, le concept du mal est évoqué, il n’est pas en général le centre de l’argumentaire. Le premier moment est celui de la pensée antique. Platon fait naître Dieu et le monde dans l’histoire des concepts puis se retrouve face l’énigme de nos crimes. La théodicée mise en place et qui sera reprise par Plotin et les Stoïciens ne cessera de nier l’existence d’un instinct pervers. Le mal voulu est une absurdité. L’irruption de la faute chrétienne bouleverse la donne. Saint Augustin en sera le théoricien le plus investi affectivement. Ayant expérimenté une double conversion dans sa vie spirituelle, il théorise une méchanceté issue de notre faiblesse, de notre faute première. Le mal est voulu car il n’est plus possible de vouloir autre chose. Saint Anselme reprend également le dogme de la chute mais lui apporte une dimension logique et sémantique en proposant une méchanceté égoïste. Le mal est certes voulu mais par dédain du bien. Notre dernière étape est kantienne. Le mal radical est le concept qui permet enfin de penser une volonté normale qui voudrait le mal simplement parce qu’elle a en elle cette possibilité et la liberté fondamentale de le choisir. Nous pourrons donc constater le chemin parcouru entre notre point de départ et notre point d’arrivée et comment cette problématisation du mal fait apparaître une généalogie de la volonté. Au fil de la pensée, elle passe de l’ombre à la lumière, n’étant jamais aussi présente que quand elle se retrouve confrontée aux obstacles. Penser le mal moral c’est faire l’archéologie de la volontéEvil provokes scandal by nature because it is what it should not be unlike good which is what it has to be. This tautological assertion expresses our feelings toward evil. It was first perfectly obvious : how must we face human pain ? Evil is a part of thinking’s history : our study starts with Platonism. Before his work, evil is just a fact of life you have to live with. The gods of Antiquity are like men : good or bad. The God of Plato is the one, omniscient, all-powerful and kindly. God is just intelligence, calculation and reason : the world he created is beautiful, ordered and perfect and it is no longer the place for the vices of ancient gods. Evils turns into a metaphysical issue : how can be the world perfect despite evil ? We have now to explain, to justify violence and crimes. Theodicy can justify pain and illness. It does not work with wickedness. Platonism, Neo-Platonism and Stoicism tried to answer this question. Following them, a conceptual break happens : Christendom invented sin. When evil became sin, man became liable and guilty. It is now a matter of liberty : man wants evil. After them, some philosophers will keep to work on the subject of the bad will. Our purpose is to find the story of these concepts and to connect thoughts between themselves. Evil has been made by this story and brings many anthropological consequences : man understands himself through evil. Wickedness is not just a matter to solve, wickedness becomes a way to define mankind. We want to show that wickedness issue is the foundations of morality and how it makes us see and think human will. Several stages occurred in this philosophical evolution. Every ethic deals with evil, not all put it at the heart of their system. Our first stage is Antiquity. Plato brings the ideas of God and perfect world in philosophy but faces the riddle of our crimes. His theodicy adopted by Plotinus and Stoics will always refuse pervert instinct in man. A man who want evil is nonsense. Christian sin appearance changes everything. Augustine will be his strongest defender. By living a double spiritual conversion, he understands wickedness as weakness due to original sin. Man want evil because he is no longer able to will something else. Anselmus follows the dogma of the fall but puts logical and semantic dimension in it and presents a self-interested wickedness. Man wants evil not for itself, man does not want enough good. Our last stage is Kant. Radical will is the first concept which allows to conceive a normal bad will which would evil just because it is one of his options and it has the liberty to do so. We can see the difference between our starting point and our arrival. We see now how the concept of will has grew up and changed. Little by little, will comes from darkness to light. The more will faces obstacles, the more it is obvious. Thinking on evil is the archaeology of the will
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Melo, Arine de Mattos 1989. "Ativação da resposta a proteínas mal formadas - UPR na prole de camundongos com obesidade induzida por dieta hiperlipídica durante a gestação e lactação." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/244519.
Full textAbstract:
Orientador: Marcio Alberto TorsoniDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Aplicadas
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Resumo: É conhecido que a obesidade materna durante a gestação e lactação expõe a prole a condições inflamatórias e leva a distúrbios metabólicos e obesidade na vida adulta. Porém, não é conhecido se o evento celular relacionado aos danos da sinalização hipotalâmica, como o estresse de retículo endoplasmático (ERE) e resistência à insulina, poderia estar presente na prole. Para responder essa questão, nós avaliamos o tecido hipotalâmico e hepático em camundongos recém desmamados (d28) e o hipotálamo de camundongos recém nascidos (d0) de mães alimentadas com dieta rica em gordura (HFD-O) e dieta controle (SC-O) durante a gestação e lactação. Peso corpóreo, massa do tecido adiposo, e ingestão alimentar foram mais acentuados em camundongo HFD-O que em camundongo SC-O. Além disso, intolerância a glicose (GTT) e insulina (ITT) foram maior em HFD-O que em SC-O. Comparado com SC-O, os níveis de RNAm de IL1-?, expressão proteica de NF?B e p-JNK no hipotálamo foram aumentados em HFD-O. Além disso, comparado ao SC-O, a fosforilação da AKT hipotalâmica após estímulo com insulina foi reduzida, enquanto os marcadores de ERE (p-PERK, p-eIF2?, XBP1s, GRP78 e GRP94) foram aumentados no tecido hipotalâmico de HFD-O com d28 mas não com d0. A fosforilação hipotalâmica da AMPK estava aumentada em HFD-O comparado a SC-O com d28. Esses danos na sinalização hipotalâmica foram acompanhados de alterações hepáticas evidenciadas pelo aumento de depósito de triglicérides, ativação de proteínas próinflamatórias (NF?B, p-IKK e p-JNK), e marcadores de ERE (p-PERK e p-eIF2?). Esses resultados indicam fortemente que o período de lactação é importante para as mudanças metabólicas. Essas mudanças podem ocorrer precocemente na prole de mães obesas e contribuir para a obesidade e patologias associadas
Abstract: It is known that maternal obesity during pregnancy and lactation exposes offspring to inflammatory conditions and leads to metabolic disturbances and obesity in adult offspring. However, it is unknown whether the cellular events related to the damage to hypothalamus signaling, such as endoplasmic reticulum stress (ERS) and insulin resistance, could be present early in the offspring. To address this question, we evaluated the hypothalamic and hepatic tissues in recently weaned mice (d28) and the hypothalamus of newborn mice (d0) from dams fed HFD (HFD-O) or standard chow diet (SC-O) during pregnancy and lactation. Body weight, adipose tissue mass, and food intake were more accentuated in HFD-O mice than in SC-O mice. In addition, intolerance to glucose (GTT) and insulin (ITT) was higher in HFD-O mice than in SC-O mice. Compared with SC-O mice, levels of hypothalamic IL1-? mRNA, NF?B protein, and p-JNK were increased in HFD-O mice. Furthermore, compared with SC-O mice, hypothalamic AKT phosphorylation after insulin challenge was reduced, while markers of ERS (p-PERK, p-eIF2?, XBP1s, GRP78, and GRP94) were increased in the hypothalamic tissue of HFD-O at d28 but not at d0. Hypothalamic AMPK phosphorylation was higher in HFD-O mice than in SC-O mice at d28. These damages to hypothalamic signaling were accompanied by hepatic alterations evidenced by increased triglyceride deposits, activation of proinflammatory proteins (NF?B, p-IKK, and p-JNK), and markers of ERS (p-PERK and p-eIF2?). Taken together, these results strongly indicate that the lactation period is important for metabolic changes. These changes may occur early in offspring from obese dams and contribute to obesity and associated pathologies
Mestrado
Metabolismo e Biologia Molecular
Mestra em Ciências da Nutrição e do Esporte e Metabolismo