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Journal articles on the topic 'Fatigue'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Duan, Zhihao, Jinliang Xu, Han Ru, and Menghui Li. "Classification of Driving Fatigue in High-Altitude Areas." Sustainability 11, no. 3 (2019): 817. http://dx.doi.org/10.3390/su11030817.

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Driving fatigue is one of the main causes of traffic accidents. Thus, to prevent traffic accidents and ensure traffic safety, the properties of driving fatigue at the wheel must be determined. The Qinghai–Tibet Plateau in China is known for its high elevation, causing hypoxia, and presence of severely cold areas; all these easily lead to fatigue during driving. This, in turn, seriously affects the traffic safety on the high-altitude highway. Therefore, the factors leading to driving fatigue and the influence of high-altitude on driving fatigue affecting the driver must be further studied. In t

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Aljahni, Mohammed A. "The Effect of Fatigue on Cognitive Tasks Among Young Adults." International Journal of Physical Therapy Research & Practice 3, no. 11 (2024): 425–35. https://doi.org/10.62464/ijoprp.v3i11.72.

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Background: This study investigates the impact of fatigue on cognitive and motor performance among young adults (18-25 years old) using the Grooved Pegboard Test (GPT). Fatigue is known to affect domains such as attention, memory, and motor skills, with physical fatigue from strenuous activities impairing cognitive performance. The study aims to assess fatigue's effect on motor speed and coordination, evaluate cognitive processing speed, and compare performance between fatigued and non-fatigued states. Methods: A Randomized Controlled Trial (RCT) was conducted with 42 participants, averaging 2

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Palotai, Miklos, Michele Cavallari, Brian C. Healy, and Charles RG Guttmann. "A novel classification of fatigue in multiple sclerosis based on longitudinal assessments." Multiple Sclerosis Journal 26, no. 6 (2020): 725–34. http://dx.doi.org/10.1177/1352458519898112.

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Background: Magnetic resonance imaging (MRI) studies of multiple sclerosis–related fatigue had limited reproducibility. Temporal fatigue fluctuations have not been considered. Objective: To investigate whether a novel group allocation that reflects temporal dynamics of fatigue improves our ability to detect fatigue-associated structural brain abnormalities. Methods: Patient stratification based on biennial fatigue assessments: sustained fatigue (SF, n = 29, fatigued at the latest ⩾2 assessments), one time-point fatigue (1F, n = 15, fatigued at the latest, but non-fatigued at the penultimate as

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Andreasen, AK, J. Jakobsen, T. Petersen, and H. Andersen. "Fatigued patients with multiple sclerosis have impaired central muscle activation." Multiple Sclerosis Journal 15, no. 7 (2009): 818–27. http://dx.doi.org/10.1177/1352458509105383.

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Background The pathogenesis of fatigue in multiple sclerosis (MS) is poorly understood. Objective To elucidate the role of central motor activation we hypothesized that patients with primary fatigue have impaired central motor function and increased fatigability as compared to secondary fatigued and non-fatigued patients. Methods Sixty patients with relapsing remitting MS and an Expanded Disability Status Scale score ≤ 3.5 were recruited and grouped as fatigued (Fatigue Severity Scale (FSS) ≥ 5.0) or non-fatigued (FSS ≤ 4.0). Nineteen patients were primary fatigued, 20 secondary fatigued and 2

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Cauch-Dudek, K., S. Abbey, D. E. Stewart, and E. J. Heathcote. "Fatigue in primary biliary cirrhosis." Gut 43, no. 5 (1998): 705–10. http://dx.doi.org/10.1136/gut.43.5.705.

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Background—Fatigue is a frequent and debilitating symptom in patients with primary biliary cirrhosis (PBC).Aims—To study fatigue in relation to sleep, depression, and liver disease severity.Methods—Patients with PBC completed validated self report questionnaires measuring fatigue, sleep quality, depression, and functional capacity. Verbally reported fatigue and observer rated measure of depression and ursodeoxycholic acid (UDCA) use were recorded. Liver biochemistry and tests to rule out metabolic causes of fatigue were performed.Results—Mean age of the 88 patients enrolled was 57 years; 86% w

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Malekzadeh, Arjan, Wietske Van de Geer-Peeters, Vincent De Groot, Charlotte Elisabeth Teunissen, Heleen Beckerman, and TREFAMS-ACE Study Group. "Fatigue in Patients with Multiple Sclerosis: Is It Related to Pro- and Anti-Inflammatory Cytokines?" Disease Markers 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/758314.

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Objective. To investigate the pathophysiological role of pro- and anti-inflammatory cytokines in primary multiple sclerosis-related fatigue.Methods. Fatigued and non-fatigued patients with multiple sclerosis (MS) were recruited and their cytokine profiles compared. Patients with secondary fatigue were excluded. Fatigue was assessed with the self-reported Checklist Individual Strength (CIS20r), subscale fatigue. A CIS20r fatigue cut-off score of 35 was applied to differentiate between non-fatigued (CIS20r fatigue≤34) and fatigued (CIS20r fatigue≥35) patients with MS. Blood was collected to dete

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Martin, Tristan, Rosie Twomey, Mary E. Medysky, John Temesi, S. Nicole Culos-Reed, and Guillaume Y. Millet. "The Relationship between Fatigue and Actigraphy-Derived Sleep and Rest–Activity Patterns in Cancer Survivors." Current Oncology 28, no. 2 (2021): 1170–82. http://dx.doi.org/10.3390/curroncol28020113.

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Cancer-related fatigue can continue long after curative cancer treatment. The aim of this study was to investigate sleep and rest–activity cycles in fatigued and non-fatigued cancer survivors. We hypothesized that sleep and rest–activity cycles would be more disturbed in people experiencing clinically-relevant fatigue, and that objective measures of sleep would be associated with the severity of fatigue in cancer survivors. Cancer survivors (n = 87) completed a 14-day wrist actigraphy measurement to estimate their sleep and rest–activity cycles. Fatigue was measured using the Functional Assess

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Moll, I., J. M. N. Essers, R. G. J. Marcellis, et al. "Lower limb muscle fatigue after uphill walking in children with unilateral spastic cerebral palsy." PLOS ONE 17, no. 12 (2022): e0278657. http://dx.doi.org/10.1371/journal.pone.0278657.

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Fatigue during walking is a common complaint in cerebral palsy (CP). The primary purpose of this study is to investigate muscle fatigue from surface electromyography (sEMG) measurements after a treadmill-based fatigue protocol with increasing incline and speed in children with CP with drop foot. The secondary purpose is to investigate whether changes in sagittal kinematics of hip, knee and ankle occur after fatigue. Eighteen subjects with unilateral spastic CP performed the protocol while wearing their ankle-foot orthosis and scored their fatigue on the OMNI scale of perceived exertion. The me

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Road, J., R. Vahi, P. del Rio, and A. Grassino. "In vivo contractile properties of fatigued diaphragm." Journal of Applied Physiology 63, no. 2 (1987): 471–78. http://dx.doi.org/10.1152/jappl.1987.63.2.471.

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The effects of fatigue on diaphragmatic contractility in vivo are unknown. In this study we used sonomicrometry to examine the velocity of shortening and lengthening and the amount of shortening in the fresh and fatigued canine hemidiaphragm (8 dogs) including the force generated. Fatigue was produced by epiphrenic stimulation of the left phrenic nerve; the right hemidiaphragm acted as the control. We found that 1) hemidiaphragmatic fatigue caused an increase in frequency with reduced tidal volume; 2) fatigue resulted in a near complete cessation of tidal shortening during spontaneous breathin

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Kumamoto, Tsuneo, Toshiaki Seko, Ryo Matsuda, and Sayo Miura. "Repeated standing back extension exercise: Influence on muscle shear modulus change after lumbodorsal muscle fatigue." Work 68, no. 4 (2021): 1229–37. http://dx.doi.org/10.3233/wor-213452.

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BACKGROUND: In low back pain, multifidus muscle fibers reportedly exhibit increased stiffness. Low back pain was associated with lumbodorsal muscle fatigue. There is no report of using shear modulus to verify the mechanism of an immediate effect of exercise on low back pain. Here, temporary lumbodorsal muscle fatigue was created, simulating fatigue-related nonspecific low back pain. OBJECTIVE: To assess the effect of standing back extension exercise on fatigued lumbodorsal muscle based on the results of multifidus muscle elasticity measured using shear wave elastography. METHODS: Thirty-three

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Barrios, Liliana, Rok Amon, Pietro Oldrati, Marc Hilty, Christian Holz, and Andreas Lutterotti. "Cognitive fatigability assessment test (cFAST): Development of a new instrument to assess cognitive fatigability and pilot study on its association to perceived fatigue in multiple sclerosis." DIGITAL HEALTH 8 (January 2022): 205520762211177. http://dx.doi.org/10.1177/20552076221117740.

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Background Fatigue is a common symptom of many diseases, including multiple sclerosis. It manifests as a cognitive or physical condition. Fatigue is poorly understood, and effective therapies are missing. Furthermore, there is a lack of methods to measure fatigue objectively. Fatigability, the measurable decline in performance during a task, has been suggested as a complementary method to quantify fatigue. Objective To develop a new and objective measurement of cognitive fatigability and investigate its association with perceived fatigue. Methods We introduced the cognitive fatigability assess

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Lin, Heng, Han Wang, and Yu Ke. "Research on optimization and improvement of sports fatigue training based on biomechanical principles." Molecular & Cellular Biomechanics 22, no. 5 (2025): 1561. https://doi.org/10.62617/mcb1561.

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Sports fatigue represents a very important obstacle in athletic performance and it creates the movement inefficiencies, increased injury risk and longer recovery time. It puts forth an integrated fatigue monitoring framework using a biomechanical assessment, a physiological monitoring and a predictive modelling for optimizing fatigue management and training adaptations. The specific techniques utilized to quantify fatigue induced changes in movement efficiency, neuromuscular coordination, autonomic activity are 3D Motion Analysis Systems, Heart Rate Variability (HRV) monitoring, and Infrared T

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Sartain, S., M. McDonnell, M. Dingwall, et al. "P359 Persistence of severe fatigue in adults with Crohn's disease in remission." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i764. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0489.

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Abstract Background Fatigue is a frequent manifestation in patients with Inflammatory Bowel Disease (IBD), including those in remission. The persistence of fatigue over time in inactive disease is not well known. We aimed to determine the prevalence and continuation of severe fatigue at baseline and at 12 months follow-up in a cohort of patients with Crohn’s disease (CD) in remission. Methods Adult patients with CD in remission, defined by age ≥18 years, HBI &lt;5 and faecal calprotectin &lt;250mcg/g, were recruited to the INTICO2 observational study. Baseline assessment included SF36,

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Hernandez, Luis, and Clayton Camic. "Fatigue-Mediated Loss of Complexity is Contraction-Type Dependent in Vastus Lateralis Electromyographic Signals." Sports 7, no. 4 (2019): 78. http://dx.doi.org/10.3390/sports7040078.

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The purpose of this study was to investigate the effect of fatigue status and contraction type on complexity of the surface electromyographic (sEMG) signal. Twelve females (mean age ± SD = 21.1 ± 1.4 years) performed three fatigue-inducing protocols that involved maximal concentric, eccentric, or isometric knee-extensor contractions over three non-consecutive sessions. Pre- and post-fatigue assessments were also completed each session and consisted of three maximal efforts for each type of contraction. Complexity of sEMG signals from the vastus lateralis was assessed using Sample Entropy (Samp

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Calabrese, Massimiliano, Francesca Rinaldi, Paola Grossi, et al. "Basal ganglia and frontal/parietal cortical atrophy is associated with fatigue in relapsing—remitting multiple sclerosis." Multiple Sclerosis Journal 16, no. 10 (2010): 1220–28. http://dx.doi.org/10.1177/1352458510376405.

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Background: Fatigue is one of the most frequent symptoms suffered by patients affected by multiple sclerosis. The patho-physiological basis of multiple sclerosis-related fatigue remains to be elucidated. Objective: Our aim was to investigate whether a particular pattern of deep and/or cortical grey matter atrophy is associated with fatigue in patients with multiple sclerosis. Methods: A total of 152 patients with relapsing—remitting multiple sclerosis were evaluated with the Expanded Disability Status Scale, the Fatigue Severity Status Scale (FSS), the Modified Fatigue Impact Scale and the Bec

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Veauthier, C., H. Radbruch, G. Gaede, et al. "Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study." Multiple Sclerosis Journal 17, no. 5 (2011): 613–22. http://dx.doi.org/10.1177/1352458510393772.

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Background: Sleep disorders can cause tiredness. The relationship between sleep disorders and fatigue in patients with multiple sclerosis (MS) has not yet been investigated systematically.Objective: To investigate the relationship between fatigue and sleep disorders in patients with MS.Methods: Some 66 MS patients 20 to 66 years old were studied by overnight polysomnography. Using a cut-off point of 45 in the Modified Fatigue Impact Scale (MFIS), the entire cohort was stratified into a fatigued MS subgroup ( n = 26) and a non-fatigued MS subgroup ( n = 40).Results: Of the fatigued MS patients,

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Chou, Yun-Jen, Kord M. Kober, Ching-Hua Kuo, et al. "A Pilot Study of Metabolomic Pathways Associated With Fatigue in Survivors of Colorectal Cancer." Biological Research For Nursing 23, no. 1 (2020): 42–49. http://dx.doi.org/10.1177/1099800420942586.

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Background: Over 30% of cancer survivors experience chronic fatigue. An alteration in energy metabolism is one of the hypothesized mechanisms for cancer-related fatigue (CRF). No studies have evaluated for changes in metabolic profiles in cancer survivors with CRF. The purpose of this pilot study was to evaluate for differences in metabolic profiles between fatigued and non-fatigued survivors of colorectal cancer (CRC). Methods: Survivors were recruited from the surgical outpatient department and the oncology clinic of a medical center in northern Taiwan. Fatigue was assessed using the Fatigue

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Penedo, Tiago, Paula Favaro Polastri, Sérgio Tosi Rodrigues, et al. "Motor strategy during postural control is not muscle fatigue joint-dependent, but muscle fatigue increases postural asymmetry." PLOS ONE 16, no. 2 (2021): e0247395. http://dx.doi.org/10.1371/journal.pone.0247395.

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The aim of this study was to investigate the effects of ankle and hip muscle fatigue on motor adjustments (experiment 1) and symmetry (experiment 2) of postural control during a quiet standing task. Twenty-three young adults performed a bipedal postural task on separate force platforms, before and after a bilateral ankle and hip muscle fatigue protocol (randomized). Ankle and hip muscles were fatigued separately using a standing calf raise protocol (ankle fatigue) on a step and flexion and extension of the hip (hip fatigue) sitting on a chair, at a controlled movement frequency (0.5Hz), respec

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Damasceno, Alfredo, Benito Pereira Damasceno, and Fernando Cendes. "Atrophy of reward-related striatal structures in fatigued MS patients is independent of physical disability." Multiple Sclerosis Journal 22, no. 6 (2015): 822–29. http://dx.doi.org/10.1177/1352458515599451.

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Background: MRI studies have shown gray-matter abnormalities in fatigued multiple sclerosis (MS) patients. However, given that physical disability is highly correlated to MS fatigue, it is often difficult to disentangle its effect in these MRI findings. Objective: The objective of this research paper is to investigate gray-matter damage in mildly disabled MS patients, addressing which variables were better related to fatigue while controlling for physical disability and depression. Methods: Forty-nine relapsing–remitting MS (RRMS) patients and 30 controls underwent MRI (3T). Fatigue was assess

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Stanzl-Tschegg, Stefanie E. "OS11W0385 Gigacycle fatigue and fatigue crack growth." Abstracts of ATEM : International Conference on Advanced Technology in Experimental Mechanics : Asian Conference on Experimental Mechanics 2003.2 (2003): _OS11W0385. http://dx.doi.org/10.1299/jsmeatem.2003.2._os11w0385.

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Demers, K., B. C. Bongers, D. M. A. E. Jonkers, M. J. Pierik, and L. P. S. Stassen. "P478 Fatigue, physical fitness, and physical activity in patients with inflammatory bowel disease." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i958—i959. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0608.

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Abstract Background Fatigue is a common and debilitating symptom in patients with Inflammatory Bowel Disease (IBD) with a great impact on quality of life and work productivity. A better comprehension of the contributing factors to fatigue could potentially pave the way for more targeted and effective strategies for managing fatigue in IBD. Fatigue may be associated with lower levels of physical activity and reduced physical fitness. Yet, the interaction between these factors in IBD, measured with validated tests, is not fully understood. Therefore, this study aimed to investigate the associati

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Liu, Xinjing, Komal Kenkare, Shanshan Li, et al. "Increased Th17/Treg Ratio in Poststroke Fatigue." Mediators of Inflammation 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/931398.

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Fatigue is a major debilitating symptom after stroke. The biological mechanisms underlying poststroke fatigue (PFS) are unknown. We hypothesized that PSF is associated with an alteration in the balance between Th17 and Treg cells. To test this hypothesis we assessed fatigue in 30 stroke survivors using the Fatigue Scale for Motor and Cognitive Functions (FSMC). Peripheral blood was collected for assessment of Th17 and Treg cell populations and measurement of interleukin-10 (IL-10). Participants were dichotomized into severe fatiguen=14and low-moderate fatiguen=16groups byK-mean cluster analysi

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Borren, N., M. Long, J. van der Woude, R. Sandler, and A. Ananthakrishnan. "P778 Longitudinal trajectory of fatigue in inflammatory bowel disease patients: a prospective study." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S616—S617. http://dx.doi.org/10.1093/ecco-jcc/jjz203.906.

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Abstract Background Fatigue is a commonly reported and sometimes disabling symptom in patients with inflammatory bowel disease (IBD). Its prevalence, mechanism, and impact remain poorly understood. Using a large cohort of patients with IBD, we aimed to prospectively determine the trajectory of fatigue and to identify determinants and impact of incident and prevalent fatigue on patients with IBD. Methods This prospective study was nested within the IBD partners cohort, a validated internet-based cohort of patients with IBD. Participants were invited to prospectively complete questionnaires asse

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Asprusten, Tarjei Tørre, Maria Pedersen, Eva Skovlund, and Vegard Bruun Wyller. "EBV-requisitioning physicians’ guess on fatigue state 6 months after acute EBV infection." BMJ Paediatrics Open 3, no. 1 (2019): e000390. http://dx.doi.org/10.1136/bmjpo-2018-000390.

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We assessed referring medical practitioner’s ability to predict chronic fatigue development in adolescents presenting with acute infectious mononucleosis. Compared with ‘not fatigued’ being predicted as ‘unsurely fatigued’ and ‘likely fatigued’ were both strongly associated with developing fatigue 6 months later (OR 2.5, 95% CI 1.16% to 5.47% and 3.2, 95% CI 1.19% to 8.61%, respectively, P=0.012). The positive and negative predictive values were 66% and 62%, respectively. Disentangling the physician’s intuition may be of interest in further investigations of risk factors and prophylactic facto

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Griesbaum, M. G., T. Vogl, S. Andreu-Sánchez, et al. "P193 Fatigued patients with Inflammatory Bowel Disease exhibit distinct systemic antibody epitope repertoires." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i507—i508. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0323.

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Abstract Background Patients with inflammatory bowel diseases (IBD) frequently experience fatigue, affecting up to 80% of those with active disease and approximately 50% with quiescent disease. The exact cause of IBD-associated fatigue is often unknown, making clinical management very challenging. In this study we aimed to explore whether patients with quiescent IBD reporting fatigue exhibit specific systemic antibody responses, which could provide insight into immune reactivities underlying fatigue. Methods Systemic antibody epitope repertoires were profiled in 327 patients with IBD (156 Croh

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Buunk, A. M., F. F. Siebenga, M. C. A. Kramer, et al. "P01.08.B MENTAL FATIGUE IN PATIENTS WITH LOW-GRADE GLIOMA: ASSOCIATIONS WITH NEUROCOGNITIVE FUNCTIONING AND TUMOR CHARACTERISTICS." Neuro-Oncology 25, Supplement_2 (2023): ii27—ii28. http://dx.doi.org/10.1093/neuonc/noad137.082.

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Abstract BACKGROUND Fatigue is a frequent consequence of low-grade glioma (LGG), but the causes are still barely understood. Specifically mental fatigue might be related to cognitive impairment such as mental slowness and decreased attention. Also, patients with greater tumor volumes or tumors in certain locations (such as the frontal cortex) might have more cognitive impairments and experience more fatigue. The aim of the present study was twofold: (1) to examine the relationship between mental fatigue and information processing speed and complex attention and (2) to investigate the associati

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Andreasen, AK, E. Stenager, and U. Dalgas. "The effect of exercise therapy on fatigue in multiple sclerosis." Multiple Sclerosis Journal 17, no. 9 (2011): 1041–54. http://dx.doi.org/10.1177/1352458511401120.

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Background: Fatigue occurs in the majority of patients with multiple sclerosis (MS) and therapeutic possibilities are few. Exercise therapy is a therapeutic option but no studies have systematically reviewed the existing literature evaluating the effect of exercise therapy on MS fatigue. Objective: To determine the effect of exercise therapy on MS fatigue by systematically reviewing the literature. Methods: A comprehensive literature search (PubMed, SweMed +, Embase, Cochrane, CINAHL, PEDro, Sport Discuss and Bibliotek.dk) was conducted. Results: Studies evaluating the effect of exercise thera

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Mao, Ping Li, Zheng Liu, Yang Li, and Li Jia Chen. "Low Cycle Fatigue Behavior of As-Extruded AZ31 Magnesium Alloy." Materials Science Forum 686 (June 2011): 202–7. http://dx.doi.org/10.4028/www.scientific.net/msf.686.202.

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The investigation on fatigue behavior and fracture surfaces of fatigued specimens of as-extruded AZ31 magnesium alloy can provide a reliable theoretical foundation for both fatigue resistant design and reasonable application of magnesium alloys. Through total-strain-amplitude controlled fatigue tests and analysis on fracture surfaces of fatigued specimens, the behavior of cyclic stress response and fatigue life as well as fracture mechanism were identified for as-extruded AZ31 magnesium alloy. The experimental results show that the extruded AZ31 alloy exhibits significant cyclic strain hardeni

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Luo, Ze Fu, Shi Ming Cui, Yan Zeng Wu, and Qing Yuan Wang. "Super Long Life Fatigue Properties of Rail Steel U71Mn and U75V." Advanced Materials Research 690-693 (May 2013): 1753–56. http://dx.doi.org/10.4028/www.scientific.net/amr.690-693.1753.

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Railway track steel, U71Mn and U75V were fatigued in this study, with the help of ultrasonic fatigue test system, to investigate the high cycle fatigue life behaviors. The results showed that the fatigue damage still occurs when the fatigue life exceeds 107, and the evolution of S-N curve showed a ladder type. This test showed that the traditional view of fatigue design and life prediction method were unable to meet the requirements of machinery and equipment working in gigacycle fatigue range, very high cycle fatigue behavior of fatigue has become a major challenge for researchers. The scanni

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Contessa, Paola, Carlo J. De Luca, and Joshua C. Kline. "The compensatory interaction between motor unit firing behavior and muscle force during fatigue." Journal of Neurophysiology 116, no. 4 (2016): 1579–85. http://dx.doi.org/10.1152/jn.00347.2016.

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Throughout the literature, different observations of motor unit firing behavior during muscle fatigue have been reported and explained with varieties of conjectures. The disagreement amongst previous studies has resulted, in part, from the limited number of available motor units and from the misleading practice of grouping motor unit data across different subjects, contractions, and force levels. To establish a more clear understanding of motor unit control during fatigue, we investigated the firing behavior of motor units from the vastus lateralis muscle of individual subjects during a fatigu

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Chung, Linda H., Damien M. Callahan, and Jane A. Kent-Braun. "Age-related resistance to skeletal muscle fatigue is preserved during ischemia." Journal of Applied Physiology 103, no. 5 (2007): 1628–35. http://dx.doi.org/10.1152/japplphysiol.00320.2007.

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During voluntary contractions, the skeletal muscle of healthy older adults often fatigues less than that of young adults, a result that has been explained by relatively greater reliance on muscle oxidative metabolism in the elderly. Our aim was to investigate whether this age-related fatigue resistance was eliminated when oxidative metabolism was minimized via ischemia induced by cuff (220 mmHg). We hypothesized that 1) older men ( n = 12) would fatigue less than young men ( n = 12) during free-flow (FF) contractions; 2) both groups would fatigue similarly during ischemia; and 3) reperfusion w

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Dominguese, David J., Jeff Seegmiller, and B. Andrew Krause. "Alterations in Peak Ground-Reaction Force During 60-cm Drop Landings Caused by a Single Session of Repeated Wingate Anaerobic Tests." Journal of Sport Rehabilitation 21, no. 4 (2012): 306–12. http://dx.doi.org/10.1123/jsr.21.4.306.

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Context:Lower extremity injury is prevalent among individuals participating in sports. Numerous variables have been reported as predisposing risk factors to injury; however, the effects of muscle fatigue on landing kinetics are unclear.Objectives:To investigate the effects of a single session of repeated muscle fatigue on peak vertical ground-reaction force (GRF) during drop landings.Design:Mixed factorial with repeated measures.Setting:Controlled laboratory.Participants:10 female and 10 male healthy recreational athletes.Intervention:Subjects performed 3 fatigued drop landings (60 cm) after f

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Jain, Saransh, Nuggehalli Puttareviyah Nataraja, and Vijaya Kumar Narne. "The Effect of Subjective Fatigue on Auditory Processing in Musicians and Nonmusicians." Music Perception 39, no. 3 (2022): 309–19. http://dx.doi.org/10.1525/mp.2022.39.3.309.

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We assessed fatigue's effect on temporal resolution and speech perception in noise abilities in trained instrumental musicians. In a pretest-posttest quasiexperimental research design, trained instrumental musicians (n = 39) and theater artists as nonmusicians (n = 37) participated. Fatigue was measured using a visual analog scale (VAS) under eight fatigue categories. The temporal release of masking measured the temporal resolution, and auditory stream segregation assessed speech perception in noise. Entire testing was carried out at two time-points: before and after rehearsal. Each participan

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Dolovich, C. L., S. Chochinov, G. Ly, et al. "A229 THE ASSOCIATION OF MENTAL HEALTH DISORDERS WITH FATIGUE AND PHYSICAL ACTIVITY IN PERSONS WITH IBD." Journal of the Canadian Association of Gastroenterology 8, Supplement_1 (2025): i95. https://doi.org/10.1093/jcag/gwae059.229.

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Abstract Background Fatigue is one of the most common symptoms among persons with inflammatory bowel disease (IBD) that impairs their quality of life. Fatigue acts as one of the greatest barriers of physical activity (PA) participation in adults with chronic disease, while PA is a strong contributor to improving fatigue symptoms. Aims The aim of this study was to assess the relationship between fatigue and PA in patients with IBD. A secondary aim was to assess the impact of mental health and disease activity on both PA and fatigue outcomes. Methods Participants from the University of Manitoba

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Johansson, S., C. Ytterberg, K. Gottberg, L. Widén Holmqvist, and L. von Koch. "Use of health services in people with multiple sclerosis with and without fatigue." Multiple Sclerosis Journal 15, no. 1 (2009): 88–95. http://dx.doi.org/10.1177/1352458508095730.

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Objective To explore and compare the use of health services in people with multiple sclerosis (MS) with and without fatigue. Methods Over a period of 30 months, the use of health services in 48 MS outpatients with persistent fatigue and 36 without fatigue was studied. Data were collected from a computerized register and by interviews, and analyzed with regard to disease severity categorized as mild or moderate/severe MS. Results Fatigued people with mild MS used more hospital outpatient care and primary care including rehabilitation, and a higher proportion had transportation service, compared

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Tsivouraki, Niki, Konstantinos Tserpes, and Ioannis Sioutis. "Modelling of Fatigue Delamination Growth and Prediction of Residual Tensile Strength of Thermoplastic Coupons." Materials 17, no. 2 (2024): 362. http://dx.doi.org/10.3390/ma17020362.

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Thermoplastic composites are continuously replacing thermosetting composites in lightweight structures. However, the accomplished work on the fatigue behavior of thermoplastics is quite limited. In the present work, we propose a numerical modeling approach for simulating fatigue delamination growth and predicting the residual tensile strength of quasi-isotropic TC 1225 LM PAEK thermoplastic coupons. The approach was supported and validated by tension and fatigue (non-interrupted and interrupted) tests. Fatigue delamination growth was simulated using a mixed-mode fatigue crack growth model, whi

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Townsend, Liam, David Moloney, Ciaran Finucane, et al. "Fatigue following COVID-19 infection is not associated with autonomic dysfunction." PLOS ONE 16, no. 2 (2021): e0247280. http://dx.doi.org/10.1371/journal.pone.0247280.

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Background The long-term clinical and physiological consequences of COVID-19 infection remain unclear. While fatigue has emerged as a common symptom following infection, little is known about its links with autonomic dysfunction. SARS-CoV-2 is known to infect endothelial cells in acute infection, resulting in autonomic dysfunction. Here we set out to test the hypothesis that this results in persistent autonomic dysfunction and is associated with post-COVID fatigue in convalescent patients. Methods We recruited 20 fatigued and 20 non-fatigued post-COVID patients (median age 44.5 years, 36/40 (9

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Rzepka, Michalina, Mateusz Toś, Michał Boroń, Katarzyna Gibas, and Ewa Krzystanek. "Relationship between Fatigue and Physical Activity in a Polish Cohort of Multiple Sclerosis Patients." Medicina 56, no. 12 (2020): 726. http://dx.doi.org/10.3390/medicina56120726.

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Background and objectives: Fatigue is one of the most common and disabling symptoms of multiple sclerosis (MS). It can be defined as a subjective lack of physical and mental energy. The aim of this study was to evaluate the frequency and severity of fatigue in patients with MS and its relationship with overall physical activity and disease-related disability. Materials and Methods: The study included 100 patients with a clinical relapsing-remitting form of MS. Patients with severe depression were excluded. Neurological impairment was rated using the Expanded Disability Status Scale (EDSS). Fat

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Williams, Jay H., Christopher W. Ward, Espen E. Spangenburg, and Reagan M. Nelson. "Functional aspects of skeletal muscle contractile apparatus and sarcoplasmic reticulum after fatigue." Journal of Applied Physiology 85, no. 2 (1998): 619–26. http://dx.doi.org/10.1152/jappl.1998.85.2.619.

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This study examined the effects of fatigue on the functional aspects of the contractile apparatus and sarcoplasmic reticulum (SR). Frog semitendinosus muscles were stimulated to fatigue, and skinned fibers or a homogenate fraction was prepared from both fatigued and rested contralateral muscles. In fatigued fibers, maximal Ca2+-activated force of the contractile apparatus was unaltered, whereas maximal actomyosin-ATPase activity was depressed by 20%. The Ca2+ sensitivity of force was increased, whereas that of actomyosin-ATPase was not altered. Also, the rate constant for tension redevelopment

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Donnelly, Elizabeth A., Paul Bradford, Matthew Davis, Cathie Hedges, Doug Socha, and Peter Morassutti. "Fatigue and Safety in Paramedicine." CJEM 21, no. 6 (2019): 762–65. http://dx.doi.org/10.1017/cem.2019.380.

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ABSTRACTObjectivesExtant research has established an empirical relationship between fatigue and safety-related outcomes. It is not clear if these findings are relevant to Canadian paramedicine. The purpose of this study was to determine if fatigue and shiftwork variables were related to safety outcomes in Canadian paramedics.MethodsA survey was conducted with ten paramedic services in Ontario with a 40.5% response rate (n = 717). Respondents reported levels of fatigue, safety outcomes (injury, safety compromising behaviours, and medical errors/adverse events), work patterns (types of shifts, h

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Timmons, Shane, and Ruth MJ Byrne. "Moral fatigue: The effects of cognitive fatigue on moral reasoning." Quarterly Journal of Experimental Psychology 72, no. 4 (2018): 943–54. http://dx.doi.org/10.1177/1747021818772045.

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We report two experiments that show a moral fatigue effect: participants who are fatigued after they have carried out a tiring cognitive task make different moral judgements compared to participants who are not fatigued. Fatigued participants tend to judge that a moral violation is less permissible even though it would have a beneficial effect, such as killing one person to save the lives of five others. The moral fatigue effect occurs when people make a judgement that focuses on the harmful action, killing one person, but not when they make a judgement that focuses on the beneficial outcome,

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Borren, Nienke Z., William Tan, Francis P. Colizzo, et al. "Longitudinal Trajectory of Fatigue With Initiation of Biologic Therapy in Inflammatory Bowel Diseases: A Prospective Cohort Study." Journal of Crohn's and Colitis 14, no. 3 (2019): 309–15. http://dx.doi.org/10.1093/ecco-jcc/jjz148.

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Abstract Backgrounds and Aims Fatigue is prevalent in patients with inflammatory bowel diseases [IBD]. Biologic therapy is effective in achieving symptomatic and endoscopic remission, but its impact on fatigue is less well established. Our aim is to define the longitudinal trajectory of fatigue over 1 year in patients initiating biologic therapy. Methods This prospective cohort enrolled patients diagnosed with Crohn’s disease [CD] or ulcerative colitis [UC] initiating biologic therapy with infliximab, adalimumab, ustekinumab, or vedolizumab. Fatigue was quantified using the seven-point fatigue

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Jiang, Xinyue, Kanesan Muthusamy, Jian Chen, and Xueliang Fang. "Scented Solutions: Examining the Efficacy of Scent Interventions in Mitigating Driving Fatigue." Sensors 24, no. 8 (2024): 2384. http://dx.doi.org/10.3390/s24082384.

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Fatigued driving threatens the safety of people’s lives and property. Scent countermeasures offer minimal disruption and high efficacy, making them a promising approach. The aim of this study was to explore the application of scent countermeasures in alleviating fatigued driving. This study explored changes in EEG frequency bands (alpha, beta, theta, and gamma) and the activity of EEG metrics (R(α/β), Rθ/(α+β) and R(α+θ)/(α+β)) in the temporal lobe during driving tasks, selected fatigued driving identifiers, and aided validation by investigating subjective fatigue with the Karolinska Sleepines

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Prinsen, Hetty, Jolanda de Vries, Foekje Stelma, et al. "Humoral and cellular immune response after influenza vaccination in patients with postcancer fatigue and patients with chronic fatigue syndrome." Journal of Clinical Oncology 30, no. 15_suppl (2012): 9070. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.9070.

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9070 Background: Postcancer fatigue (PCF) is a frequently occurring problem, impairing quality of life. Patients with chronic fatigue syndrome (CFS) also suffer from severe fatigue symptoms. We hypothesized that in fatigued patients (PCF and CFS) alterations in immune response could explain fatigue symptoms. Therefore, we examined whether the humoral and/or cellular immune response after influenza vaccination differed between fatigued patients and non-fatigued individuals and between PCF and CFS patients. Methods: PCF (n=15) and CFS patients (n=22) were vaccinated against influenza. Age and ge

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Mgbekem, Mary A., Emilia J. Oyira, Regina Ella, Felicia Lukpata, Margaret Armon, and Gabriel U. Ntamu. "Counseling fatigue of HIV/AIDS counselor in Calabar, Nigeria." Calabar Journal of Health Sciences 3 (February 4, 2020): 16–24. http://dx.doi.org/10.25259/cjhs_6_2019.

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Objective: There is different perception of HIV/AIDS counselling fatique among counsellors of patients. This descriptive study assessed perceived HIV/AIDS counseling fatigue among HIV/AIDS counselors in Calabar, Nigeria. Materials and Methods: A total of 90 counselors were assessed using a 35-item questionnaire measuring a variety of counseling activities. Fatigue was ranked on a 5-point Likert-type scale. The counseling fatigue was categorized in five subscales: accessibility of clients for HIV Counseling and Testing (HCT), explains and facilitates, monitoring and follow through, trusting rel

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Manocchio, Nicola, Ornella Argento, Michela Bossa, et al. "The Role of the Cerebellum in Multiple Sclerosis-Related Fatigue and Disability." Journal of Clinical Medicine 14, no. 8 (2025): 2840. https://doi.org/10.3390/jcm14082840.

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Background: Fatigue is a prevalent and debilitating symptom in people with multiple sclerosis (pwMS), significantly impairing quality of life. While the cerebellum is traditionally associated with motor control, emerging evidence suggests its involvement in cognitive, emotional, and integrative functions. This study aimed to explore the relationship between fatigue components (physical, cognitive, and psychosocial), clinical disability, and cerebellar structural changes in pwMS acquired via magnetic resonance imaging (MRI). Methods: Participants of this cross-sectional study underwent clinical

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Rinaldin, Carla D. P., Julia A. Oliveira, Caroline R. Souza, Daniel B. Coelho, and Luis A. Teixeira. "Does footedness affect bilateral plantar flexor responses to sudden stance perturbations under unilateral lower leg muscular fatigue?" Brazilian Journal of Motor Behavior 17, no. 5 (2023): 186–92. http://dx.doi.org/10.20338/bjmb.v17i5.381.

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BACKGROUND: Analysis of performance asymmetries has indicated that the right and left cerebral hemispheres are specialized for specific functions of motor control. AIM: In the current investigation, we aimed to evaluate the effect of leg dominance on electrical activation of the plantar flexor muscles in responses to unanticipated stance perturbations in a state muscular fatigue of the dominant leg. METHOD: Fatigue was induced through ankle isometric contraction targeting 40% of maximum voluntary contraction. Muscle activation of the triceps surae of the dominant and non-dominant legs were com

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Gobbi, C., MA Rocca, G. Riccitelli, et al. "Influence of the topography of brain damage on depression and fatigue in patients with multiple sclerosis." Multiple Sclerosis Journal 20, no. 2 (2013): 192–201. http://dx.doi.org/10.1177/1352458513493684.

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Objectives: Involvement of selected central nervous system (CNS) regions has been associated with depression and fatigue in MS. We assessed whether specific regional patterns of lesion distribution and atrophy of the gray (GM) and white matter (WM) are associated with these symptoms in MS. Methods: Brain dual-echo and 3D T1-weighted images were acquired from 123 MS patients (69 depressed (D), 54 non-depressed (nD), 64 fatigued, 59 non-fatigued) and 90 controls. Lesion distribution, GM and WM atrophy were estimated using VBM and SPM8. Results: Gender, age, disease duration and conventional MRI

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Zhou, Chenyi, Linwei Wang, and Yanqun Yang. "Dialogue at the Edge of Fatigue: Personalized Voice Assistant Strategies in Intelligent Driving Systems." Applied Sciences 15, no. 12 (2025): 6792. https://doi.org/10.3390/app15126792.

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With the rapid development of intelligent transportation systems, voice assistants are increasingly integrated into driving environments, providing an effective means to mitigate the risks of fatigued driving. This study explored drivers’ interaction preferences with voice assistants under different fatigue states and proposed a fatigue-state-based dialogue-awakening mechanism. Using Grounded Theory and the Stimulus–Organism–Response (SOR) framework, in-depth interviews were conducted with 25 drivers from diverse occupational backgrounds. To validate the qualitative findings, a driving simulat

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Wahyuni, Islah. "MANAGEMEN KELELAHAN SAAT PERSALINAN MENGGUNAKAN JUS SEMANGKA." Jurnal Ipteks Terapan 12, no. 1 (2018): 19. http://dx.doi.org/10.22216/jit.2018.v12i1.2385.

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<em>The condition of fatigue during labor has received little attention for meditative intervention, so it is important in suppressing the adverse effects of fatigue during labor on the mother and fetus, and preventing the incidence of maternal and fetal mortality and morbidity. The purpose of the study to determine the handling of fatigue using watermelon juice in maternal mothers. Anaerobic fatigue was measured using blood lactic acid values, and Visual Analoque Scale-Fatique (VAS-F) quetioner from 68 respondents were divided into 2 groups: treatment and control group were selected con

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