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Feliu, María, Anabel Impa Condori, Inés Fernandez, and Nora Slobodianik. "Omega 3 Fatty Acids vs Omega 6 Fatty Acids." Current Developments in Nutrition 6, Supplement_1 (June 2022): 512. http://dx.doi.org/10.1093/cdn/nzac077.015.
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Abstract Objectives Dietary lipids have a very important role in nutrition and must be ingested in an appropriate proportion. Objective: To study the effect of w3 fatty acid supplementation of a diet containing sunflower oil (rich in fatty acids omega 6) as fat source, on serum fatty acid profiles of growing rats. Methods Weanling Wistar rats received during 10 days normocaloric diet and fat was provided by sunflower oil (S group). The others groups received the same diet supplemented with 24mg/day of fish oil (SF group) or chía oil (SCh group). Control group (C) received AIN´93 diet. Serum fatty acids profiles were determined by gas chromatography. Statistical analysis used ANOVA test. Results Results: (expressed as %Area) SERUM: OLEIC C:10.11 ± 1.84, S:12.13 ± 3.84, SCh:12.74 ± 1.56, SF: 13.12 ± 2.82; ARACHIDONIC C:13.40 ± 4.39, S:17.61 ± 4.09, SCh: 15.75 ± 0.89, SF:15.41 ± 1.76; LINOLEIC C:20.52 ± 3.37, S: 19.80 ± 3.36, SCh: 21.14 ± 2.12, SF: 18.92 ± 3.87; LINOLENIC (ALA) C:0.93 ± 0.27a, S:0.19 ± 0.06 b, SCh: 0.28 ± 0.08b, SF:0.22 ± 0.05b; EPA C:0.80 ± 0.22, S:0.68 ± 0.15, SCh: 0.74 ± 0.18, SF: 0.67 ± 0.14; DHA C:1.60 ± 0.55a, S:1.14 ± 0.35a, SCh:1.70 ± 0.45a, SF:4.22 ± 0.93b. Media that didn't present a letter (a, b) in common, were different (p < 0.01). In sera, S, SF and SCh groups showed lower ALA levels compared to C. SF group presented high levels of DHA. Diet S was mainly a contributor to linoleic acid with a ratio w6/w3 = 250 (recommended value: 5–10). Conclusions The diet containing sunflower oil as fat source shows that ω6 family route was exacerbated; by the other hand ω3 family was depressed. Chia supplement showed a tendency towards higher values of w3 family but were significantly lower than C. Fish oil supplement increase significantly DHA values. Diet containing sunflower oil as fat source provoked changes in serum fatty acids profiles and the supplementation with w3 fatty acid provided by chía or fish oil do not increase ALA values significantly. Diet influences the serum fatty acid profile, being not only important the percentage of lipids on it but also the different fatty acids pattern. Funding Sources UBACyT: 20020190100093BA.
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Dupont, Jacqueline. "Omega-6 Essential Fatty Acids." Journal of the American College of Nutrition 10, no. 2 (April 1991): 178. http://dx.doi.org/10.1080/07315724.1991.10738173.
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K.W.J.W. "Omega-6 essential fatty acids." Trends in Biochemical Sciences 15, no. 10 (October 1990): 405. http://dx.doi.org/10.1016/0968-0004(90)90251-6.
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Innes, Jacqueline K., and Philip C. Calder. "Omega-6 fatty acids and inflammation." Prostaglandins, Leukotrienes and Essential Fatty Acids 132 (May 2018): 41–48. http://dx.doi.org/10.1016/j.plefa.2018.03.004.
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Aryani, Titin, Fitria Siswi Utami, and Sulistyaningsih Sulistyaningsih. "IDENTIFIKASI ASAM LEMAK OMEGA PADA ASI EKSKLUSIF MENGGUNAKAN KROMATOGRAFI GC-MS." Journal of Health Studies 1, no. 1 (March 28, 2017): 1–7. http://dx.doi.org/10.31101/jhes.180.
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Abstract: Quantitative research aims to identify the omega fatty acids in exclusive breast milk (ASI) Exclusive. The data analysis used data chromatogram Gas Chromatography-Mass Spectrometry (GC-MS). The data generated is breast milk (ASI) had higher levels of omega-3 fatty acids amounting to 28.24%, omega-6 and omega of 0.57% 9 at 26.56%. The conclusion from this study is there is the content of omega-3, omega-6, omega-9 fatty acids in breast milk (ASI). Highest levels of omega fatty acids in breast milk is the omega-3 fatty acid that is equal to 28.24%.Keywords: milk, omega fatty acids, GC-MS
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Haag, Marianne. "Essential Fatty Acids and the Brain." Canadian Journal of Psychiatry 48, no. 3 (April 2003): 195–203. http://dx.doi.org/10.1177/070674370304800308.
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Objective: To review the role of essential fatty acids in brain membrane function and in the genesis of psychiatric disease. Method: Medline databases were searched for published articles with links among the following key words: essential fatty acids, omega-3 fatty acids, docosahexanoic acid, eicosapentanoic acid, arachidonic acid, neurotransmission, phospholipase A2, depression, schizophrenia, mental performance, attention-deficit hyperactivity disorder, and Alzheimer's disease. Biochemistry textbooks were consulted on the role of fatty acids in membrane function, neurotransmission, and eicosanoid formation. The 3-dimensional structures of fatty acids were obtained from the Web site of the Biochemistry Department, University of Arizona (2001). Results: The fatty acid composition of neuronal cell membrane phospholipids reflects their intake in the diet. The degree of a fatty acid's desaturation determines its 3-dimensional structure and, thus, membrane fluidity and function. The ratio between omega-3 and omega-6 polyunsaturated fatty acids (PUFAs), in particular, influences various aspects of serotoninergic and catecholaminergic neurotransmission, as shown by studies in animal models. Phospholipase A2 (PLA2) hydrolyzes fatty acids from membrane phospholipids: liberated omega-6 PUFAs are metabolized to prostaglandins with a higher inflammatory potential, compared with those generated from the omega-3 family. Thus the activity of PLA2 coupled with membrane fatty acid composition may play a central role in the development of neuronal dysfunction. Intervention trials in human subjects show that omega-3 fatty acids have possible positive effects in the treatment of various psychiatric disorders, but more data are needed to make conclusive directives in this regard. Conclusion: The ratio of membrane omega-3 to omega-6 PUFAs can be modulated by dietary intake. This ratio influences neurotransmission and prostaglandin formation, processes that are vital in the maintenance of normal brain function.
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Sefer, Dragan, Stamen Radulovic, Dejan Peric, Matija Sefer, Lazar Makivic, Svetlana Grdovic, and Radmila Markovic. "Domestic chicken omega 3 – a product for promoting human health." IOP Conference Series: Earth and Environmental Science 854, no. 1 (October 1, 2021): 012081. http://dx.doi.org/10.1088/1755-1315/854/1/012081.
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Abstract Literature data show that the relationship between two groups of polyunsaturated fatty acids in diet, omega 3 acids, whose basic representative is a-linolenic acid (C18: 3 n-3), and omega 6 acids, whose basic representative is linoleic acid (C18: 2 n-6), has a significant role in development of cardiovascular diseases in humans. The optimal ratio of omega 6 to omega 3 fatty acids is around 4:1. In monogastric animals, the fatty acids in feed are absorbed in the gastrointestinal tract largely unchanged. This means the fatty acid profile of the animal’s diet directly reflects the fatty acid profile of the tissue. The daily intake of unsaturated fatty acids can be increased by an adequate animal nutrition strategy. Flaxseed contains ten times more unsaturated (32.26%) than saturated (3.66%) fatty acids. The largest amount of unsaturated fatty acids (about 70%) is a-linolenic acid (ALA), which is a precursor of the entire omega 3 series of fatty acids, and which makes flaxseed an ideal raw material for the production of a wide range of omega 3 enriched products. In order to obtain chicken meat rich in omega 3, an experiment was organized with a specific diet for broilers at fattening. Thanks to the designed animal feed, it was possible to get products (meat, breast, drumstick, liver, subcutaneous fat) with significantly higher amounts of omega 3 fatty acids compared to the same products obtained from broilers fed with conventional mixtures, or with almost the ideal ratio between omega 6 and omega 3 fatty acids.
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M, Halim, and Halim A. "Omega 3 versus Omega 6 Polyunsaturated Fatty Acids in Cardio-Metabolic Health." Journal of Health Care and Research 1, no. 2 (June 27, 2020): 83–100. http://dx.doi.org/10.36502/2020/hcr.6166.
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Background: Cardiometabolic diseases like type 2 diabetes, metabolic syndrome, heart failure, and other cardiovascular complications are the leading cause of mortality and morbidity across the globe. These conditions are directly attributed to modifiable behaviors such as sedentary activity, poor diet, excessive consumption of alcohol, or smoking. Efforts aimed towards their prevention and management are, therefore, not only essential in the accomplishment of the healthy populations but also for eliminating the associated cost and health burdens. Dietary change is an important approach to the promotion of cardiometabolic health. Omega 3 (C20–22 ω3) polyunsaturated fatty acids have pleiotropic effects on the functioning of cells, control inflammatory factors, and cellular events in vascular endothelial cells and cardiomyocytes. The hypolipemic, anti-arrhythmic, and anti-inflammatory properties of fatty acids offer cardioprotection. Government agencies and national heart associations recommend increased consumption of omega 3 polyunsaturated fatty acids (PUFA) supplements and fish to prevent cardiometabolic diseases. Purpose of the Study: The purpose of this study is to investigate the role played by ω-3 and ω-6 polyunsaturated fatty acids in promoting cardiometabolic health. Methods: The research study searched databases such as MEDLINE®, Embase, PsycINFO, CINAHL® and the Cochrane Library for relevant research studies evaluating the function/benefits of polyunsaturated fatty acids particularly ω-3 and ω-6 polyunsaturated fatty acids in promoting cardiometabolic functions published between 2011 and 2020. A total of 77 research studies were identified and used in the meta-analysis. Results: Results from the meta-analysis indicated that polyunsaturated fatty acids lower the risk for cardiovascular disease by limiting inflammation of blood vessels, reducing thrombosis, increasing levels of high-density lipoproteins, reducing levels of low-density lipoproteins, and reducing risk factors associated with hypertension. Conclusion: Given the benefits of polyunsaturated fatty acids lower the risk for cardiovascular diseases indicted in the meta-analysis. Therefore, human diets must contain the required amounts of PUFA due to the associated benefits.
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SOBCZAK, S., A. HONIG, A. CHRISTOPHE, M. MAES, R. W. C. HELSDINGEN, S. DE VRIESE, and W. J. RIEDEL. "Lower high-density lipoprotein cholesterol and increased omega-6 polyunsaturated fatty acids in first-degree relatives of bipolar patients." Psychological Medicine 34, no. 1 (January 2004): 103–12. http://dx.doi.org/10.1017/s0033291703001090.
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Background. Lower serum high-density lipoprotein cholesterol and increased ratio of omega-6/omega-3 fatty acids have been reported in unipolar and bipolar depressed patients. Changes in cholesterol and fatty acids have been suggested to affect membrane viscosity and consequently serotonergic neurotransmitter expression.The goal of this study was to investigate whether lower baseline cholesterol and increased omega-6 and lower omega-3 fatty acids are present in healthy first-degree relatives of bipolar patients compared with controls and whether these changes were associated with neuroendocrine responses to an i.v. tryptophan challenge or mood.Method. Baseline cholesterol, fatty acids and mood were determined in healthy first-degree relatives of patients with bipolar disorders (N=30) and healthy matched controls (N=15) (parallel-group design). Prolactin and cortisol were measured following tryptophan infusion.Results. First-degree relatives showed significantly lower plasma high-density lipoprotein cholesterol and increased total omega-6 fatty acids in phospholipids. Lower total omega-3 and higher total omega-6 fatty acids in phospholipids were positively correlated with peak prolactin response to tryptophan. Lower total omega-3 fatty acids in phospholipids and cholesteryl esters were associated with lower mood.Conclusions. Abnormalities of lower plasma high-density lipoprotein cholesterol and increased total omega-6 fatty acids in phospholipids in these subjects are in agreement with findings in bipolar and major depressed patients. Changes in fatty acids show an association with central serotonergic parameters. It is suggested that these abnormalities in cholesterol and fatty acids may constitute a trait marker for bipolar disorders.
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Harris, William S., and Gregory C. Shearer. "Omega-6 Fatty Acids and Cardiovascular Disease." Circulation 130, no. 18 (October 28, 2014): 1562–64. http://dx.doi.org/10.1161/circulationaha.114.012534.
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Sanders, Thomas A. B. "Omega-6 Fatty Acids and Cardiovascular Disease." Circulation 139, no. 21 (May 21, 2019): 2437–39. http://dx.doi.org/10.1161/circulationaha.119.040331.
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Mozaffarian, Dariush. "Omega-6 fatty acids and cardiovascular disease." Nutrafoods 11, no. 3 (September 2012): 81–84. http://dx.doi.org/10.1007/s13749-012-0035-x.
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Chen, Xi, Xue Du, Jianliang Shen, Lizhi Lu, and Weiqun Wang. "Original Research: Effect of various dietary fats on fatty acid profile in duck liver: Efficient conversion of short-chain to long-chain omega-3 fatty acids." Experimental Biology and Medicine 242, no. 1 (October 4, 2016): 80–87. http://dx.doi.org/10.1177/1535370216664031.
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Omega-3 fatty acids, especially long-chain omega-3 fatty acids, have been associated with potential health benefits for chronic disease prevention. Our previous studies found that dietary omega-3 fatty acids could accumulate in the meat and eggs in a duck model. This study was to reveal the effects of various dietary fats on fatty acid profile and conversion of omega-3 fatty acids in duck liver. Female Shan Partridge Ducks were randomly assigned to five dietary treatments, each consisting of 6 replicates of 30 birds. The experimental diets substituted the basal diet by 2% of flaxseed oil, rapeseed oil, beef tallow, or fish oil, respectively. In addition, a dose response study was further conducted for flaxseed and fish oil diets at 0.5%, 1%, and 2%, respectively. At the end of the five-week treatment, fatty acids were extracted from the liver samples and analyzed by GC-FID. As expected, the total omega-3 fatty acids and the ratio of total omega-3/omega-6 significantly increased in both flaxseed and fish oil groups when compared with the control diet. No significant change of total saturated fatty acids or omega-3 fatty acids was found in both rapeseed and beef tallow groups. The dose response study further indicated that 59–81% of the short-chain omega-3 ALA in flaxseed oil-fed group was efficiently converted to long-chain DHA in the duck liver, whereas 1% of dietary flaxseed oil could produce an equivalent level of DHA as 0.5% of dietary fish oil. The more omega-3 fatty acids, the less omega-6 fatty acids in the duck liver. Taken together, this study showed the fatty acid profiling in the duck liver after various dietary fat consumption, provided insight into a dose response change of omega-3 fatty acids, indicated an efficient conversion of short- to long-chain omega-3 fatty acid, and suggested alternative long-chain omega-3 fatty acid-enriched duck products for human health benefits.
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Filipović, J., M. Ivkov, M. Košutić, and V. Filipović. "Ratio of omega-6/omega-3 fatty acids of spelt and flaxseed pasta and consumer acceptability." Czech Journal of Food Sciences 34, No. 6 (December 21, 2016): 522–29. http://dx.doi.org/10.17221/384/2015-cjfs.
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The chemical composition and content of fatty acids in flaxseed and spelt flour were evaluated. The ratio of ω-6/ω-3 essential fatty acids is also analysed in spelt pasta and pasta with 0, 10, and 20% of flaxseed flour. Flaxseed flour has a better fatty acid profile than spelt flour, with low levels of saturated fat (approximately 8.99 g/100 g of flour) and a high concentration of linolenic acid (57.20 g/100 g of flour) and lower content of linoleic acid (15.98 g/100 g of flour), as well as superior ω-6/ω-3 ratio of 1 : 4. Flaxseed flour in pasta positively contributes to the daily intake of essential fatty acids recommended by nutritionists and the improvement of ω-6/ω-3 ratio. Although a new product is worse in texture quality, it will be acceptable to consumers who want to change their habits related to diet and enrich it with functional components.
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Hartik, Hartik, Boedi Setya Rahardja, and Agustono Agustono. "Potensi Pemberian Cod Liver Oil (CLO) pada Pakan Komersial Terhadap Jumlah Total Asam Lemak Omega 3 dan Omega 6 Di Daging Udang Galah (Macrobrachium Rosenbergii) [Potential Of Giving Cod Liver Oil (CLO) Commercial Feed On To The Total Amount of Omega 3 and Omega 6 Fatty Acid in Meat Giant Freshwater Prawn (Macrobrachium Rosenbergii)]." Jurnal Ilmiah Perikanan dan Kelautan 9, no. 1 (April 1, 2017): 65. http://dx.doi.org/10.20473/jipk.v9i1.7634.
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AbstrakAsam lemak omega 3 dan omega 6 adalah asam lemak tak jenuh yang termasuk kedalam golongan Poly Unsaturated Fatty Acid (PUFA) dan juga termasuk dalam kelompok asam lemak esensial. Asam lemak omega 3 dan omega 6 tidak dapat disintesis sendiri oleh tubuh, sehingga perlu adanya suplai asam lemak omega 3 dan omega 6 di makanan yang dikonsumsi. Fungsi dari asam lemak omega 3 dan omega 6 secara fisiologis yaitu sebagai sumber penting dalam menunjang pertumbuhan dan kelangsungan hidup krustacea. Penelitian ini bertujuan untuk mengetahui potensi pemberian Cod Liver Oil (CLO) pada pakan komersial terhadap jumlah total asam lemak omega 3 dan omega 6 di daging udang galah (Macrobrachium rosenbergii). Metode penelitian yang digunakan adalah percobaan dengan Rancangan Acak Lengkap sebagai rancangan percobaan. Perlakuan yang digunakan adalah kandungan Cod Liver Oil (CLO) yang berbeda, yaitu P0 (0%), P1 (3%), P2(6%), P3 (9%), P4(12%) masing-masing perlakuan diulang sebanyak 4 kali. Parameter utama yang diamati adalah jumlah total asam lemak omega 3 dan omega 6 di daging udang galah. Parameter penunjang yang diamati adalah parameter kualitas air. Analisis data menggunakan analisis of varian (ANOVA) dan untuk mengetahui perlakuan terbaik dilakukan uji jarak berganda Duncan. Hasil penelitian pemberian Cod Liver Oil (CLO) menunjukkan berbeda nyata (P<0,05) terhadap jumlah total asam lemak omega 3 tetapi tidak berbeda nyata (P>0,05) dengan jumlah total asam lemak omrga 6 di daging udang galah (Macrobrachium rosenbergii). Jumlah total asam lemak omega 3 pada perlakuan P0 (0%) berbeda nyata dengan perlakuan P2 (6%), P3 (9%) dan P4 (12%), tetapi tidak berbeda nyata dengan perlakuan P1. Jumlah total asam lemak omega 6 pada perlakuan P0 (0%) tidak berbeda nyata dengan perlakuan P1 (3%), P2 (6%), P3 (9%) dan P4 (12%). AbstractFatty acids omega 3 and omega 6 unsaturated fatty acids are included into class Poly Unsaturated Fatty Acid (PUFA) and is also included in a group of essential fatty acids.Fatty acids omega 3 and omega 6 can not be synthesized by the body, so it is necessary to supply fatty acids omega 3 and omega 6 in the food consumed. This study aims to determine the potential for the provision of Cod Liver Oil (CLO) on a commercial feed to the total amount of fatty acids omega 3 and omega 6 in the flesh of giant fresh water prawn (Macrobrachium rosenbergii). The method used is experiment with completely randomized design as the experimental design. The treatment used is the content of Cod Liver Oil (CLO) that is different, that P0 (0%), P1 (3%), P2 (6%), P3 (9%), P4 (12%) of each treatment was repeated 4 times. The main parameters measured were the number of total fatty acids omega 3 and omega 6 in meat prawns. Supporting parameters measured were water quality parameters. Analysis of data using analysis of variance (ANOVA) and to determine the best treatment Duncan's multiple range test. The results of the research granting Cod Liver Oil (CLO) showed significantly (P <0.05) of the total amount of omega 3 fatty acids but not significantly different (P> 0.05) with the total amount of fatty acids omrga 6 in the meat giant fresh water prawn (Macrobrachium rosenbergii). The total amount of omega 3 fatty acids in the treatment of P0 (0%) was significantly different from P2 treatment (6%), P3 (9%) and P4 (12%), but not significantly different from P1 treatment. The total amount of fatty acids in the treatment omega 6 P0 (0%) did not differ significantly with treatment P1 (3%), P2 (6%), P3 (9%) and P4 (12%).
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Harris, William. "Omega-6 and omega-3 fatty acids: partners in prevention." Current Opinion in Clinical Nutrition and Metabolic Care 13, no. 2 (March 2010): 125–29. http://dx.doi.org/10.1097/mco.0b013e3283357242.
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Horrobin, David. "Omega-6 and Omega-3 Essential Fatty Acids in Atherosclerosis." Seminars in Thrombosis and Hemostasis 19, no. 02 (April 1993): 129–37. http://dx.doi.org/10.1055/s-2007-994016.
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Sora, Gisele Teixeira de Souza, Aloisio Henrique Pereira Souza, Acácio Antônio Ferreira Zielinski, Charles Windson Isidoro Haminiuk, Makoto Matsushita, and Rosane Marina Peralta. "FATTY ACID COMPOSITION OF Capsicum GENUS PEPPERS." Ciência e Agrotecnologia 39, no. 4 (August 2015): 372–80. http://dx.doi.org/10.1590/s1413-70542015000400008.
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Fatty acids have a great metabolic and structural importance. Evaluation of fatty acid composition of peppers is still incomplete. Pulps and seeds from six varieties of the genus Capsicum were evaluated in this work with respect to their contents in fatty acids. A total of 25 different fatty acids, including some with odd number of carbons were identified in the samples. The most abundant fatty acids were palmitic (16:0), oleic (18:1n-9) and linoleic (18:2n-6) acids. The polyunsaturated:saturated fatty acid (PUFA/SFA) ratios for all peppers were high due to the elevated amounts of polyunsaturated acids, particularly linoleic acid. In the pulps, the omega-6/omega-3 ratios ranging from 1.28 to 4.33, were relatively adequate if one considers that ratios between 0.25 and 1.0 in the human diet are regarded as highly appropriate. In the seeds, the levels of omega-3 were very low whereas the levels of omega-6 were high, leading to very inadequate omega-6/omega-3 ratios ranging from 74.2 to 279.6. Principal component analysis (PCA) explained 93.49% of the total variance of the data. Considering the PUFA/SFA ratio and omega-6/omega-3 ratio, our data suggest that, among the peppers of the genus Capsicum evaluated in this work, the bell pepper and orange habanero pepper present the best nutritional characteristics concerning fatty acid composition.
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Berezhnaya, Irina V., Irina N. Zakharova, Mariia A. Simakova, and Aleksandra I. Sgibneva. "Polyunsaturated fatty acids: omega-3 and omega-6 and nonalcoholic fatty liver disease." Pediatrics. Consilium Medicum, no. 4 (December 15, 2021): 335–40. http://dx.doi.org/10.26442/26586630.2021.4.201348.
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The history of the study of polyunsaturated fatty acids (PUFAs) began over 100 years ago. In 1909. P. Hartley isolated arachidonic acid. Later, 21 years later, Burr and Burr in 1930 showed its positive effect on the growth and development of rats. The important thing about this work was that after reintroduction of PUFAs into the diet of rodents, body functions began to recover. It took over 60 years from the time of the discovery of arachidonic acid to prove its effect on the cardiovascular system. Today, research into the effects of long-chain PUFAs on human health, intelligence, the immune system, neuronal connections, the course of pregnancy and infant health has led to recommendations for the widespread use of foods or supplements containing omega-3 PUFAs. Unbalanced diets in children and adolescents, selective appetite, and eating disorders lead to the development of deficit conditions, cognitive impairment, obesity, and metabolic syndrome with liver damage. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are asymptomatic in the early stages, but it is during this period that the prognosis in children can be changed. This article reviews international recommendations for the integrated use of long-chain PUFAs in the treatment of NAFLD and NASH in children. Supplementation of the diet with high-quality purified fish oil replenishes the requirement, improves disease prognosis, reduces insulin resistance and the level of liver fibrosis in patients with NAFLD and NASH.
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Svahn, Sara L., Marcus A. Ulleryd, Louise Grahnemo, Marcus Ståhlman, Jan Borén, Staffan Nilsson, John-Olov Jansson, and Maria E. Johansson. "Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced Sepsis." Infection and Immunity 84, no. 4 (February 8, 2016): 1205–13. http://dx.doi.org/10.1128/iai.01391-15.
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Sepsis caused byStaphylococcus aureusis increasing in incidence. With the alarming use of antibiotics,S. aureusis prone to become methicillin resistant. Antibiotics are the only widely used pharmacological treatment for sepsis. Interestingly, mice fed high-fat diet (HFD) rich in polyunsaturated fatty acids have better survival ofS. aureus-induced sepsis than mice fed HFD rich in saturated fatty acids (HFD-S). To investigate what component of polyunsaturated fatty acids, i.e., omega-3 or omega-6 fatty acids, exerts beneficial effects on the survival ofS. aureus-induced sepsis, mice were fed HFD rich in omega-3 or omega-6 fatty acids for 8 weeks prior to inoculation withS. aureus. Further, mice fed HFD-S were treated with omega-3 fatty acid metabolites known as resolvins. Mice fed HFD rich in omega-3 fatty acids had increased survival and decreased bacterial loads compared to those for mice fed HFD-S afterS. aureus-induced sepsis. Furthermore, the bacterial load was decreased in resolvin-treated mice fed HFD-S afterS. aureus-induced sepsis compared with that in mice treated with vehicle. Dietary omega-3 fatty acids increase the survival ofS. aureus-induced sepsis by reversing the deleterious effect of HFD-S on mouse survival.
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Novitsky, V. V., R. S. Karpov, S. V. Klimenkov, A. B. Salmina, M. Yu Kotlovsky, S. V. Mashkovskaya, D. A. Kirichenko, et al. "Role of blood plasma fatty acids in pathogenesis of stable anginapectoris." Bulletin of Siberian Medicine 6, no. 4 (December 30, 2007): 41–45. http://dx.doi.org/10.20538/1682-0363-2007-4-41-45.
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In men and women suffering from stable angina pectoris of 1-2 functional classes and aged from 35 to 69 years old, decrease of C 23:0 and increase of C 18:1(11) fatty acids was observed regardless of sex, the content of the rest fatty acids changed depending on patients sex. Correlation was found that metabolism of fatty acids in this pathology group depends on patients sex: men in the control group showed decrease in the sum of omega-3 fatty acids as well as in the omega-3/omega-6 fatty acid ratio, while women showed decrease of omega-6 fatty acids at the constant sum of omega-3 fatty acids. Regardless of sex, the presence of this pathology is accompanied with decrease in correlations between fatty acids, as the number of correlations between saturated fatty acids increases and the number of correlations between not saturated and saturated fatty aсids decreases. Change in correlations between not saturated fatty acids depends on sex. In the number of patients having supernormal fatty acid contents, no pronounced differences were found between men and women.
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Simopoulos, Artemis P. "Genetic Variation, Diet, Inflammation, and the Risk for COVID-19." Lifestyle Genomics 14, no. 2 (2021): 37–42. http://dx.doi.org/10.1159/000513886.
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COVID-19, which is caused by SARS-CoV-2, is characterized by various symptoms, ranging from mild fatigue to life-threatening pneumonia, “cytokine storm,” and multiorgan failure. The manifestation of COVID-19 may lead to a cytokine storm, i.e., it facilitates viral replication that triggers a strong release of cytokines, which then modulates the immune system and results in hyperinflammation. Today’s diet is high in omega-6 fatty acids and deficient in omega-3 fatty acids; this, along with a high fructose intake, leads to obesity, which is a chronic state of low-grade inflammation. Omega-6 fatty acids are proinflammatory and prothrombotic whereas omega-3 fatty acids are less proinflammatory and thrombotic. Furthermore, omega-3 fatty acids make specialized lipid mediators, namely resolvins, protectins, and maresins, that are potent anti-inflammatory agents. Throughout evolution there was a balance between omega-6 and omega-3 fatty acids with a ratio of 1–2/1 omega-6/omega-3, but today this ratio is 16–20/1 omega-6/omega-3, leading to a proinflammatory state. In addition, genetic variants in FADS1, FADS2, ELOV-2, and ELOV-5 lead to a more efficient biosynthesis of long-chain polyunsaturated fatty acids (PUFAs), e.g., of linoleic acid (LA) to arachidonic acid (ARA), and (alpha-linolenic acid) (ALA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), leading to higher ARA levels. Because the US diet is already high in omega-6 fatty acids, the increased biosynthesis of ARA in people with the derived FADS haplotype (haplotype D) leads to an increased production of leukotrienes, thromboxanes, C-reactive protein (CRP), and eventually elevated levels of cytokines, like interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF), which may increase susceptibility to COVID-19. About 80% of African Americans, 50% of Hispanics, and 45% of European Americans have the FADS haplotype D and are thus efficient metabolizers, which could account for the higher vulnerability of these populations to COVID-19. Therefore, another reason that African Americans and Hispanics are more susceptible to COVID-19 is that they have a higher frequency of haplotype D, which is no longer beneficial in today’s environment and diet. Genetic variation must be considered in all studies of disease development and therapy because it is important to the practice of precision nutrition by physicians and other health professionals. The objective of this commentary is to emphasize the importance of genetic variation within populations and its interaction with diet in the development of disease. Differences in the frequency of genes and their interactions with nutrients in various population groups must be considered among the factors contributing to health disparities in the development of COVID-19. A balanced omega-6/omega-3 ratio is essential to health. Physicians should measure their patients’ fatty acids and recommend decreasing the intake of foods rich in omega-6 fatty acids and increasing the intake of omega-3 fatty acids along with fruits and vegetables.
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Simopoulos, Artemis P. "Omega-6 and omega-3 fatty acids: Endocannabinoids, genetics and obesity." OCL 27 (2020): 7. http://dx.doi.org/10.1051/ocl/2019046.
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The tissue composition of polyunsaturated fatty acids (PUFA) is important to health and depends on both dietary intake and metabolism controlled by genetic polymorphisms that should be taken into consideration in the determination of nutritional requirements, obesity and chronic disease risk. Experimental and clinical intervention studies suggest that omega-6 and omega-3 fatty acids have opposing physiological and metabolic properties and elicit divergent effects on body fat gain through mechanisms of adipogenesis, browning of adipose tissue, lipid homeostasis, systemic inflammation and an increase in the tone of the endocannabinoid system. Overweight and obese individuals have higher levels of the arachidonic acid (AA) derived endocannabinoid N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) and an altered pattern of receptor expression. Since endocannabinoids are products of dietary fats, modification of the omega-6 and omega-3 fatty acid intake modulates the endocannabinoids, with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) displacing AA from cell membranes, reducing AEA and 2-AG production, resulting in decrease in appetite and food intake leading to weight loss. Polygenic risk scores reveal susceptibility and an increase risk for obesity. Therefore, persons at risk for obesity will have to lower omega-6 and increase their omega-3 fatty acid intake in order to have a balanced ratio for health. A process needs to be established to define when genomic discoveries such as gene-nutrient-disease associations are “ready” to be evaluated as potential tools for personalized nutrition to improve public health.
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Vidrih, R., S. Filip, and J. Hribar. "Content of Higher Fatty Acids in Green Vegetables." Czech Journal of Food Sciences 27, Special Issue 1 (June 24, 2009): S125—S129. http://dx.doi.org/10.17221/621-cjfs.
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Green vegetables are considered an important source of some nutritionally important constituents that have health benefits (e.g. vitamins, minerals, antioxidants, fibre). Epidemiological data suggest that consuming a diet rich in fruit and vegetables can lower the risks for chronic diseases, such as cardiovascular diseases and cancer. Over the past 100–150 years, there have been enormous increases in the consumption of omega-6 fatty acids due to the increased intake of vegetable oils from various seeds. Studies have indicated that a high intake of omega-6 fatty acids shifts the physiological state to one that is prothrombotic and pro-aggregatory, whereas omega-3 fatty acids have anti-inflammatory, antithrombotic, anti-arrhythmic, hypolipidemic and vasodilatory properties. Literature data regarding the contents of higher fatty acids (e.g. omega-6 fatty acids) in vegetables are scarce, although vegetables are known to contain a high proportion of n-3 fatty acids. Here, the fatty acid content and composition was determined for 26 green vegetables that are commonly available in Slovenia, by gas-liquid chromatography and <I>in situ</I> transesterification. The fatty acid analysis revealed C16:0, C16:1, C18:0, C18:1, C18:2n-6 and C18:3n-3. The total fatty acid content in the vegetables ranged from 500 mg/100 g fresh weight (f.w.) in red cabbage, to 4.000 mg/100 g f.w. in tarragon. The proportion of saturated fatty acids (as g/100 g total fatty acids) ranged from 12% to 35%. All of the vegetables contained a high proportion of poly-unsaturated fatty acids (PUFAs), ranging from 45% to 81% of total fatty acids. The omega-3 PUFA proportion ranged from 5% in carrot to 60% in tarragon. The content of mono-unsaturated fatty acids ranged from 1% to 25%. French beans, tarragon and radish sprouts contained the highest concentrations of C16:1, at 5 mg/100 g f.w. Consumption of 100 g of tarragon meets 13.2% of daily requirements for α-linolenic acid; similarly, for radish sprouts 9.4%, for mangold 6.9%, for ruccola 5.4%, for green salad 5.0%, and for kale 4.7%. Green vegetables are an important source of 18:3n-3 PUFAs, especially for vegetarian populations.
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Salih, Osamah. "Effects of Dietary Omega-3 Fatty Acids (DHA/EPA) and Vitamin E on Fatty Acid Profile of Common Carp, Cyprinus carpio Ovaries." Biological and Applied Environmental Research 5, no. 1 (January 15, 2021): 10–23. http://dx.doi.org/10.51304/baer.2021.5.1.10.
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The current study aimed to clarify the fatty acids profile in the breeding stock ovaries of common carp (Cyprinus carpio L.) fed on two food additives. The study was carried out in the Shrimp Hatchery which belonging to the Basrah Agricultural Directorate. Three treatment groups were used, the first treatment (T1) represented as control without any food additives, the second treatment (T2) supplemented with 5 g/kg omega-3 fatty acids, and the third treatment (T3) to which vitamin E was added at a concentration of 200 mg/kg. Fishes were randomly distributed in three replicates for each treatment with six of common carp brood stock per replicate. Nine cages were used which placed in earthen pond. Feeding trail lasted from 29 Oct 2018 to 14 Mar 2019. After feeding fish for 82 days, the oil was extracted from gonads by two methods, the first one by Soxhlet apparatus and the second by Accelerated Solvent Extraction (ASE) method. The fatty acid profiles were analyzed using gas chromatograph by GC/MS (Gas Chromatography Mass spectrometry). Results showed that the content of fatty acids in the ovaries of treated fishes in T1, the presence of saturated and unsaturated omega-3 and omega-6 fatty acids, were monounsaturated fatty acid (C19H36:1) scored the highest percentage (52.55%). Fishes in T2 recorded the presence of saturated and unsaturated omega-3 and omega-6 fatty acids were omega-12 (C18H34:12) recorded the highest percentage (50.02%), while T3 fishes showed the presence of saturated and unsaturated fatty acids from the group of omega-6 fatty acids and the unsaturated fatty acid omega-9 (C18H34:9) record the highest percentage (63.24%).In conclusion this study suggested that the content of fatty acids in fish ovaries reflects the composition of fatty acids in the diet.
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Gören, Jessica L., and Ashley T. Tewksbury. "The Use of Omega-3 Fatty Acids in Mental Illness." Journal of Pharmacy Practice 24, no. 5 (September 22, 2011): 452–71. http://dx.doi.org/10.1177/0897190011422876.
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Purpose: This article will summarize the current evidence on the effects of omega-3 fatty acids on prevention and treatment of mental illness. Background: Omega-3 fatty acids are involved in many physiologic processes. Since they cannot be made de novo in the body, they are considered essential nutrients. As the Western diet evolved, dietary intake of fatty acids has shifted to increased omega-6 fatty acids and decreased omega-3 fatty acids intake. These changes have been correlated with numerous differences in prevalence and course of mental illnesses. Methods: A MEDLINE search from 1966 to December 2010 was completed to identify studies comparing changes in symptoms, functioning, other outcomes, and/or side effects in patients treated with omega-3 fatty acids for mental illness. The studies were reviewed and reported by specific psychiatric disorder studied. Conclusions: Omega-3 fatty acids play a role in many biologic functions. Epidemiologic data implicate omega-3 fatty acid deficiencies in many mental illnesses. Data are most robust for omega-3 fatty acids' role in affective disorders. However, data are conflicting, negative, or absent for most mental illnesses.
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Gligor, Șerban, and Răzvan Gligor. "The potential role of omega-3 fatty acids supplements in increasing athletic performance." Timisoara Physical Education and Rehabilitation Journal 9, no. 16 (September 1, 2016): 25–34. http://dx.doi.org/10.1515/tperj-2016-0004.
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Abstract Polyunsaturated omega-3 and omega-6 fatty acids are essential fatty acids that cannot be produced by the body itself and therefore must be provided through nutrition. Omega-6 and particularly omega-3 fatty acids have important roles in the organism, contributing to the maintenance and promotion of health. The optimal proportion of omega-6/omega-3 fatty acids is 2:1, or even better 1:1. They are involved in normal growth and development, play a role in the prevention of coronary and cardiovascular diseases, of diabetes mellitus, of arterial hypertension, arthritis and cancer. Omega-3 fatty acids mainly have an anti-inflammatory effect, but also act as hypolipidemic and antithrombotic agents. A potential role of omega-3 fatty acids is that of increasing physical performance. Their role in the physical activity refers on one side to the global health of athletes and on the other side to their anti-inflammatory effect, as high intensity physical exercise induces increased free-radical production and microtraumas, with the induction of an inflammatory status. The anti-inflammatory effect of these fatty acids manifests through an increased production of endogenous antioxidant enzymes, through decreasing the production of prostaglandins metabolites, decreasing the production of leukotriene B4, etc. They are also effective on reducing muscle pain post eccentric exercise and on decreasing the severity of bronchoconstriction induced by exercise, as well as improving pulmonary function variables. In conclusion it seems that supplementing diets with omega-3 fatty acids, apart from having benefic effects on health and on the prevention and management of certain affections, proves to be a beneficial for physical activity and athletic performance.
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Alagawany, Mahmoud, Shaaban S. Elnesr, Mayada R. Farag, Mohamed E. Abd El-Hack, Asmaa F. Khafaga, Ayman E. Taha, Ruchi Tiwari, et al. "Omega-3 and Omega-6 Fatty Acids in Poultry Nutrition: Effect on Production Performance and Health." Animals 9, no. 8 (August 18, 2019): 573. http://dx.doi.org/10.3390/ani9080573.
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Omega-3 (ω-3) and omega-6 (ω-6) fatty acids are important components of cell membranes. They are essential for health and normal physiological functioning of humans. Not all fatty acids can be produced endogenously owing to the absence of certain desaturases; however, they are required in a ratio that is not naturally achieved by the standard diet of industrialized nations. Poultry products have become the primary source of long-chain polyunsaturated fatty acids (LC-PUFA), with one of the most effective solutions being to increase the accretion of PUFAs in chicken products via the adjustment of fatty acids in poultry diets. Several studies have reported the favorable effects of ω-3 PUFA on bone strength, bone mineral content and density, and semen quality. However, other studies concluded negative effects of LC-PUFA on meat quality and palatability, and acceptability by consumers. The present review discussed the practical application of ω-3 and ω-6 fatty acids in poultry diets, and studied the critical effects of these fatty acids on productive performance, blood biochemistry, immunity, carcass traits, bone traits, egg and meat quality, and semen quality in poultry. Future studies are required to determine how poultry products can be produced with higher contents of PUFAs and favorable fatty acid composition, at low cost and without negative effects on palatability and quality.
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Campos, Célia Maria Teixeira de, Antônio José Simões Hamad, Jane Mara Block, José Carlos Fiad Padilha, Paulo José Ogliari, Daniel Barreira-Arellano, and Rosana Nogueira Cavalcanti Moreira. "Composition of omega-3 and omega-6 fatty acids in freeze-dried chicken embryo eggs with different days of development." Brazilian Archives of Biology and Technology 47, no. 2 (June 2004): 219–24. http://dx.doi.org/10.1590/s1516-89132004000200009.
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Fatty acids omega--3 and omega--6 composition and specially DHA were determined in freeze-dried chicken embryo eggs with pre-determined incubation periods. Fertile and embryo eggs presented palmitic (23.18 + 0.54%), stearic (7.70 + 0.28%), palmitoleic (3.00 + 0.19%), oleic (36.28 + 0.58%), linoleic (22.18 + 0.34%), linolenic (1.08 + 0.04%), arachidonic (2.04 + 0.03%), docosahexaenoic (0.91 + 0.03%), total omega-3 acids (2.26 + 0.10%) and total omega-6 acids (24.62 + 0.33%). There were no significant differences in total contents of omega-3 fatty acids (p=0.1226) between freeze-dried chicken embryo eggs with different incubation periods (3, 5, 7, 9, and 11 days) and fertile freeze-dried chicken eggs (day 0). However, there were significant differences in total medium contents of omega-6 fatty acids (p=0.0001). There was also a strong statistical evidence that quadratic model was related with expected values of DHA content (p= 0.0013).
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Zhernakova, Tatyana S., and Olesya N. Bespalova. "The potential of micronutrient support with omega-3 and omega-6 fatty acids in the prevention of human reproductive disorders." Journal of obstetrics and women's diseases 70, no. 6 (December 15, 2021): 91–104. http://dx.doi.org/10.17816/jowd65052.
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Omega-3 and omega-6 polyunsaturated fatty acids are among the nutrients essential for the vital functions of the human body. Fundamental cellular functions of omega-3 and omega-6 polyunsaturated fatty acids affect both physical and reproductive health. Based on the principles of personalized medicine, early detection of polyunsaturated fatty acid deficiency is necessary for its prompt correction and prevention of further diseases. We present a literature review on the effects of polyunsaturated fatty acids on female and male fertility. The brief information on biochemical aspects, current data on diagnosis, and possible methods for correction of polyunsaturated fatty acid deficiency are described in this article.
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Saunders, Erika F. H., Christopher E. Ramsden, Mostafa S. Sherazy, Alan J. Gelenberg, John M. Davis, and Stanley I. Rapoport. "Omega-3 and Omega-6 Polyunsaturated Fatty Acids in Bipolar Disorder." Journal of Clinical Psychiatry 77, no. 10 (September 13, 2016): e1301-e1308. http://dx.doi.org/10.4088/jcp.15r09925.
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Johnson, Mats, Sven Östlund, Gunnar Fransson, Björn Kadesjö, and Christopher Gillberg. "Omega-3/Omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder." Journal of Attention Disorders 12, no. 5 (March 2009): 394–401. http://dx.doi.org/10.1177/1087054708316261.
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Jeppesen, Charlotte, Katja Schiller, and Matthias B. Schulze. "Omega-3 and Omega-6 Fatty Acids and Type 2 Diabetes." Current Diabetes Reports 13, no. 2 (January 17, 2013): 279–88. http://dx.doi.org/10.1007/s11892-012-0362-8.
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Aragona, Pasquale, Claudio Bucolo, Rosaria Spinella, and Sebastiano Giuffrida. "Omega-6 Essential Fatty Acids and Tear PGE." Ocular Surface 3 (January 2005): S43. http://dx.doi.org/10.1016/s1542-0124(12)70345-2.
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Palmer, R. M., and K. W. J. Wahle. "Protein synthesis and degradation in isolated muscle. Effect of ω3 and ω6 fatty acids." Biochemical Journal 242, no. 2 (March 1, 1987): 615–18. http://dx.doi.org/10.1042/bj2420615.
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The ability of derivatives of the essential fatty acids linoleic acid (C18:2, omega 6) and alpha-linolenic acid (C18:3, omega 3) to stimulate rates of protein synthesis and degradation was investigated in isolated intact muscles from fasted rabbits. Both omega 6 derivatives examined, arachidonic acid (C20:4, omega 6) and dihomo-gamma-linolenic acid (C20:3, omega 6), when added at concentrations up to 1 microM, stimulated the rate of protein synthesis and the release of prostaglandin F2 alpha (PGF2 alpha). Metabolites of the omega 6 series, namely eicosapentaenoic acid (C20:5, omega 3) and docosahexaenoic acid (C22:6, omega 3), were without effect on the rate of protein synthesis and resulted in a decrease in the release of PGF2 alpha. None of the fatty acids had a significant effect on the rate of protein degradation. Although insulin (100 mu units/ml) also stimulated rates of protein synthesis when added alone, none of the omega 3 or omega 6 fatty acids, when added with insulin at concentrations of 0.2 microM, potentiated the effect of the hormone.
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Cruz-Tirado, J. P., Pedro Renann Lopes de França, and Douglas Fernandes Barbin. "Chia (Salvia hispanica) seeds degradation studied by fuzzy-c mean (FCM) and hyperspectral imaging and chemometrics - fatty acids quantification." Scientia Agropecuaria 13, no. 2 (July 4, 2022): 167–74. http://dx.doi.org/10.17268/sci.agropecu.2022.015.
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Chia seeds are nutritious food because they have a high content of protein, polyunsaturated fatty acids (omega-3 and omega-6) and phenolic compounds. During storage, fatty acids are degraded, by oxidative and hydrolytic reactions, forming free fatty acids (FFA). In this work, we used Near Infrared Hyperspectral Imaging (NIR- HSI) and chemometrics to predict FFA acid value and fatty acids concentrations in chia seeds during storage. First, we explore the hyperspectral images by Fuzzy c-means (FCM), where it is possible to observe as chemical compounds are formed or degraded during storage. Second, PLSR models were developed to predict FFA value and fatty acids concentration. RPD values reached values higher then 2.0, indicating a good ability to estimate these chemical compounds, especially polyunsaturated fatty acids omega-3 and omega-6. Finally, NIR-hyperspectral imaging coupled with chemometrics allowed us to show the chemical degradation process of chia seeds during storage, mainly associated with polyunsaturated fatty acids degradation. Besides NIR-HSI showed to be a powerful technique to quantify the main fatty acids with high accuracy.
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Vordenbäumen, Stefan, Alexander Sokolowski, Laura Kutzner, Katharina M. Rund, Christina Düsing, Gamal Chehab, Jutta G. Richter, Ralph Brinks, Matthias Schneider, and Nils H. Schebb. "Erythrocyte membrane polyunsaturated fatty acid profiles are associated with systemic inflammation and fish consumption in systemic lupus erythematosus: a cross-sectional study." Lupus 29, no. 6 (March 18, 2020): 554–59. http://dx.doi.org/10.1177/0961203320912326.
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Objective This study aimed to assess polyunsaturated fatty acid (PUFA) status and association with systemic inflammation and fish consumption in systemic lupus erythematosus (SLE). Methods Parameters of PUFA status including the proportion of omega-6 and -3 fatty acids in highly unsaturated fatty acids (omega-6%, omega-3%), essential fatty acids linoleic acid (LA) and alpha-linolenic acid (ALA), the omega-6 PUFA arachidonic acid (ARA) and the sum of key omega-3 PUFA eicosapentaenoic acid+docosahexaenoic acid (omega-3 status) were measured by gas chromatography in 68 SLE patients (88.2% female, aged 45.7±12.5 years). Associations with serum CRP, disease activity, damage and fish consumption were assessed by linear regression modelling adjusted for age, sex and body mass index. Associations are reported in terms of regression coefficients (β). Results Omega-6 PUFA were associated with higher CRP: omega-6% (β = 0.052, p = 0.02), the ratio of LA/ALA (β = 0.007, p = 0.02) and ARA (β = 0.308, p = 0.001). Conversely, omega-3% was associated with lower CRP (β = −0.051, p = 0.02). Increased dietary PUFA consumption from fish (g/day) was linked to a higher omega-3 status (β = 2.21, p = 0.02) and lower self-reported damage (Brief Index of Lupus Damage; β = −3.22, p = 0.02). Conclusions Omega-3 and omega-6 fatty acid status differentially reflect systemic inflammation in SLE and are linked to fish consumption.
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Merdzhanova, Albena, Mona Stancheva, and Lubomir Makedonski. "Fatty acid composition of Bulgarian Black Sea fish species." Analele Universitatii "Ovidius" Constanta - Seria Chimie 23, no. 1 (June 1, 2012): 41–46. http://dx.doi.org/10.2478/v10310-012-0006-5.
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Abstract The fatty acid compositions of three Black Sea fish species turbot (Pseta maxima), red mullet (Mullusbarbatus ponticus) and garfish (Belone belone) were investigated. This species are considered as preferred for consumption in Bulgaria. Lipid extraction was done according to the Bligh and Dyer method. The fatty acid composition was determined by GC/MS. The saturated fatty acids amounts were 38.32 % for turbot, 35.44 % red mullet and 42.90% for garfish. Monounsaturated fatty acids were found in lowest level in comparison with other groups for garfish (23.65%) and turbot (24.85%) while for red mullet they have a highest value - 37.56%. Omega 3 polyunsaturated fatty acids as eicosapentaenoic (C 20:5 omega 3, EPA) and docosahexaenoic (C 22:6 omega 3, DHA) acids were found in highest levels in turbot (22.26%) and garfish (21.80%) and in lowest values of red mullet (9.35%). The results showed that the fish examined are good source of omega 3 polyunsaturated fatty acids, resulting in a very favourable omega 3 / omega 6 ratios, especially in turbot and garfish
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Calderelli, Valéria Alcântara Santos, Marta de Toledo Benassi, Jesuí Vergílio Visentainer, and Graciette Matioli. "Quinoa and flaxseed: potential ingredients in the production of bread with functional quality." Brazilian Archives of Biology and Technology 53, no. 4 (August 2010): 981–86. http://dx.doi.org/10.1590/s1516-89132010000400029.
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The objective of this work was to compare the physicochemical characteristics of quinoa and flaxseed bread. Sensory acceptance, color and texture were also appraised. They showed appropriate balances between their content of polyunsaturated and saturated fatty acids and low levels of trans fatty acids. Flaxseed bread had larger amounts of mono and polyunsaturated fatty acids, omega-6 and omega-3, as well as a more balanced omega-6/omega-3 ratio. Quinoa bread, on the other hand, had the advantage of presenting smaller contents of saturated fatty acids. With regard to color and texture, quinoa bread had similar characteristics to the flaxseed bread. The quinoa bread was well accepted by the consumers, who expressed high interest in buying it.
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Onkenhout, W., V. Venizelos, P. F. van der Poel, M. P. van den Heuvel, and B. J. Poorthuis. "Identification and quantification of intermediates of unsaturated fatty acid metabolism in plasma of patients with fatty acid oxidation disorders." Clinical Chemistry 41, no. 10 (October 1, 1995): 1467–74. http://dx.doi.org/10.1093/clinchem/41.10.1467.
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Abstract The free fatty acid and total fatty acid profiles in plasma of nine patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, two with very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency and two with mild-type multiple acyl-CoA dehydrogenase (MAD-m) deficiency, were analyzed by gas chromatography-mass spectrometry. In the plasma of patients with MCAD deficiency we found increases of octanoic acid (8:0), decanoic acid (10:0), 4-decenoic acid (10:1 omega 6), and 4,7-decadienoic acid (10:2 omega 3), all present almost exclusively in free form. The patients with VLCAD deficiency showed increases of mainly 5-tetradecenoic acid (14:1 omega 9) and to a minor extent 5-dodecenoic acid (12:1 omega 7), 5,8-tetradecadienoic acid (14:2 omega 6), and 7,10-hexadecadienoic acid (16:2 omega 6), in both the free and esterified fatty acid fraction. The MAD-m patients showed variable increases of all the unusual fatty acids present in MCAD- and VLCAD-deficient plasma. The 14:1 omega 9, 14:2 omega 6, and 16:2 omega 6 fatty acids were present mainly in the esterified form. Measurement of these fatty acids in plasma by the relatively simple method presented here provides a sensitive and specific aid in the diagnosis of acyl-CoA dehydrogenase deficiency disorders.
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Serra, Monica C., Alice S. Ryan, Charlene E. Hafer-Macko, Manuel Yepes, Fadi B. Nahab, and Thomas R. Ziegler. "Dietary and Serum Omega-6/Omega-3 Fatty Acids Are Associated with Physical and Metabolic Function in Stroke Survivors." Nutrients 12, no. 3 (March 6, 2020): 701. http://dx.doi.org/10.3390/nu12030701.
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The purpose of this study was to quantify habitual dietary and systemic omega-6 and omega-3 fatty acids and their ratios and to determine their relationship with physical and metabolic function in a cohort of chronic adult stroke survivors. Twenty-five older chronic stroke survivors (age: 63 ± 8 years; BMI: 31 ± 7 kg/m2; mean ± SD) were assessed for fitness (VO2peak), gait speed (GS), 3 m timed up and go (TUG), and six-minute walk distance (6MWD). Plasma lipid and glucose profiles were measured, and HOMA-IR calculated. Dietary (5-day food records) and serum (mass spectrometry) omega-6/omega-3 profiles were assessed. Participants were severely deconditioned (VO2peak: 19 ± 4 mL/kg/min; GS: 0.88 ± 0.28 m/s; TUG: 12.6 ± 5.9 s; 6MWD: 295 ± 121 m) and at elevated metabolic risk (HOMA-IR: 6.3 ± 4.5). The dietary intake ratio of omega-6/omega-3 fatty acids averaged 12.6 ± 7.1 and the serum concentration ratio was 1.21 ± 0.37, which were correlated (r = 0.88, p < 0.01). Higher dietary intake and serum concentrations of omega-6/omega-3 fatty acids were associated with lower 6MWD and higher HOMA-IR, while a higher serum omega-6/omega-3 concentration index was associated with lower VO2peak (p’s < 0.05). These preliminary data suggest that both dietary omega-6 and omega-3 fatty acids (quantitated as their intake ratio) and the serum concentration ratio of omega-6/omega-3 may be important indices of physical dysfunction and insulin resistance in chronic stroke survivors.
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Cropotova, Janna, and Svetlana Popel. "Mercury-Contaminated Fish and Essential Fatty Acids: Problems and Solutions." Chemistry Journal of Moldova 7, no. 1 (June 2012): 162–63. http://dx.doi.org/10.19261/cjm.2012.07(1).29.
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Fish consumption is an important part of human diet due to essential omega-3 fatty acids found naturally in this product. Many researchers from all over the world found that high mercury concentrations in the body reduced the heart-protective effects of the fatty acids in fish oils. People shouldn't be constrained by choosing between the health hazards related to toxins caused by industrial pollution and the nutritional benefits provided by consummation of essential fatty acids contained in oily fish. It is very important to find an alternative natural source of essential omega-3 fatty acids EPA and DHA to restore an optimal ratio between omega-6 and omega-3 fatty acids in the human diet.
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Garg, M. L., E. Sebokova, A. B. R. Thomson, and M. T. Clandinin. "Δ 6-desaturase activity in liver microsomes of rats fed diets enriched with cholesterol and/or ω3 fatty acids." Biochemical Journal 249, no. 2 (January 15, 1988): 351–56. http://dx.doi.org/10.1042/bj2490351.
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The effect of feeding semipurified diets enriched in linseed (rich in C18:3, omega 3 fatty acid) or fish (rich in C20:5, omega 3 and C22:6, omega 3 fatty acid) oil with and without cholesterol supplementation on the desaturation of linoleic acid (C18:2, omega 6) by rat liver microsomal fractions was investigated. Animals fed diets supplemented with beef tallow were used as equal-energy controls. Both linseed-oil and fish-oil diets, without added cholesterol, decrease conversion of C18:2, omega 6 fatty acid to gamma-linolenic acid (C18:3, omega 6). Reduction in delta 6-desaturation was significantly greater for animals fed the diet containing fish oil than with animals fed the linseed-oil diet. The major effect of cholesterol supplementation was to decrease the rate of desaturation of C18:2, omega 6, when fed in combination with the beef-tallow diet, whereas delta 6-desaturation was unaffected when cholesterol was fed along with diets high in omega 3 fatty acids (linseed oil or fish oil). The activity of the delta 6-desaturase in vitro is consistent with the fatty acid composition observed for the microsomal membranes on which this enzyme is localized. Dietary linseed oil and fish oil lowered the arachidonic (C20:4, omega 6) acid content of rat liver microsomes, with an accompanying increase in membrane eicosapentaenoic (C20:5, omega 3) and docosahexaenoic (C22:6, omega 3) acid content, in comparison with the group fed beef tallow. Inclusion of cholesterol into the beef-tallow or linseed-oil diets resulted in decreased membrane C20:4, omega 6-fatty-acid content, with concomitant increase in C18:2, omega 6-fatty-acid content. However, addition of cholesterol to the fish-oil diet did not alter the microsomal membrane content of C20:4, omega 6 fatty acid. Thus it is suggested that (1) the decrease in prostaglandin E2, thromboxane and prostacyclin levels generally observed after fish-oil consumption may be at least partly due to inhibition of C20:4, omega 6-fatty-acid synthesis from C18:2, omega 6 fatty acid; and (2) consumption of fish oil prevents the further decrease in C20:4, omega 6-fatty-acid levels by dietary cholesterol that is apparent when cholesterol is fed in combination with diets high in saturated fat or C18:3, omega 3 fatty acid.
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Guichardant, M., and M. Lagarde. "Monohydroxylated fatty acid substrate specificity of human leukocyte 5-lipoxygenase and ω-hydroxylase." Biochemical Journal 256, no. 3 (December 15, 1988): 879–83. http://dx.doi.org/10.1042/bj2560879.
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Various monohydroxylated fatty acids were synthesized from eicosapolyenoic acids, namely arachidonic (20:4 omega-6), timnodonic (20:5 omega-3), dihomogammalinolenic (20:3 omega-6) and mead (20:3 omega-9) acids. 12-Hydroxy derivatives, as well as 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT), were produced with platelets as the enzyme source, and 15-hydroxy derivatives were produced by soya bean lipoxygenase treatment. Each monohydroxylated fatty acid was incubated with human leukocytes in the presence or absence of the calcium ionophore A23187, and dihydroxylated products were analysed by h.p.l.c. 12-Hydroxy derivatives of 20:4 omega-6, 20:5 omega-3 and 20:3 omega-9 were similarly oxygenated by both the 5-lipoxygenase and the omega-hydroxylase. As expected, the 12-hydroxy derivative of 20:3 omega-6 was not a substrate for 5-lipoxygenase, but surprisingly, omega-6 oxygenated products, like 15-OH-20:4 or HHT, were not converted by the enzyme, although being potential substrates because of the presence of two double bonds at C-5 and C-8. omega-6 oxygenated derivatives were also poorly converted by leukotriene B4 omega-hydroxylase, a cytochrome P-450-dependent enzyme. It is concluded that both leukocyte 5-lipoxygenase and omega-hydroxylase exhibit a substrate specificity towards monohydroxylated fatty acids with respect to their double bonds and/or the carbon position of the alcohol function.
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Haag, M., and M. Coetzee. "The highly unsaturated fatty acids: physiological role and clinical possibilities." Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie 25, no. 4 (September 22, 2006): 266–83. http://dx.doi.org/10.4102/satnt.v25i4.169.
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Fatty acids play a very important role in human physiology. Except for the fact that fatty acids in stored triglycerides can be used for energy production, fatty acids from dietary lipids are transported in plasma and built into various cellular structures. The fatty acid profile of cell membrane phospholipids plays a determining role in the cell membrane in that it influences fluidity, receptor function and the type of eicosanoids that can be synthesised from it. Fatty acids also have highly differentiated inputs in cellular transduction mechanisms and regulation of gene transcription. In this, the steric conformation plays a large role: the straight-chain saturated and trans-fatty acids, when compared with the unsaturated fatty acids with progressively more bent chains, lead to a variety of mechanisms that have less positive effects on our health. In this regard, the two most important families of polyunsaturated fatty acids, the so-called omega-3 and omega-6 fatty acids, also lead to different effects. Changes in the pattern of dietary fatty acid intake through the ages have lead to an increased intake of saturated, trans- and omega-6 fatty acids relative to omega-3 fatty acids. Clinical trials during the past twenty years have shown that dietary supplementation with omega-3 fatty acids can lead to an improvement of the symptoms of certain lifestyleassociated disorders. Atherosclerosis, obesity, type 2 diabetes mellitus, depression, schizophrenia, Alzheimer’s disease, attention deficit hyperactivity disorder in young children, certain types of cancer, osteoporosis in the elderly and some dermatological disorders are amongst the conditions that can be addressed in this manner.
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Akbar, Samina, Muhammad Zeeshan Bhatti, Rida Fatima Saeed, and Asma Saleem Qazi. "Polyunsaturated Fatty Acids: Impact on Health and Disease Status." Life and Science 2, no. 2 (April 2, 2021): 12. http://dx.doi.org/10.37185/lns.1.1.85.
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Over the last decades, the polyunsaturated fatty acids (PUFAs) have been largely explored not only for their nutritional value but also for the numerous biological functions and therapeutic effects. The serum and erythrocyte levels of PUFAs depend on the genetic control of metabolism as well as the dietary intake and are considered to reflect the health and disease status of an individual. Two families of PUFAs, omega-3 (n-3) and omega-6 (n-6), have gained much attention because of their involvement in the production of bioactive lipid mediators and therefore, a balanced omega-6/omega-3 ratio is crucial in maintaining the overall health of an individual. Omega-3 PUFAs, notably eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) have been shown to exert beneficial effects, possibly due to their lipid-lowering, anti-inflammatory, anti-hypertensive and cardioprotective effects, whereas omega-6 fatty acids such as arachidonic acid (ARA, 20:4n-6) exhibit the opposite properties. Even though, numerous epidemiological studies and clinical interventions have clearly established the effectiveness of omega-3 PUFAs in various pathological conditions including dyslipidemia, obesity, diabetes, cancer, cardiovascular and neurodegenerative diseases, some controversies do exist about the beneficial effects of omega-3 PUFAs and need to be clarified. Larger clinical trials with extended follow-up periods are required along with a careful dose selection, in order to confirm the clinical significance and efficacy of omega-3 PUFAs as therapeutic agents.
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Pandiangan, Maruba, Jamaran Kaban, Basuki Wirjosentono, and Jansen Silalahi. "Analisis Kandungan Asam Lemak Omega 3 dan Omega 6 pada Minyak Ikan Mas (Cyprinus Carpio)." Talenta Conference Series: Science and Technology (ST) 2, no. 1 (January 30, 2019): 37–44. http://dx.doi.org/10.32734/st.v2i1.309.
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Penelitian ini bertujuan untuk mengetahui komponen asam lemak omega-3 dan omega-6 pada minyak ikan mas. Penelitian ini dilakukan di Laboratorium Pengolahan Pangan Fakultas Pertanian Universitas Katolik Santo Thomas, Medan. Pelaksanaan penelitian ini dilakukan pada bulan Agustus 2016 hingga Oktober 2016. Minyak ikan mas diperoleh dengan menggunakan proses rendering kering. Dari uji sifat fisika kimia diperoleh semakin besar nilai angka asam maka semakin rendah kualitas minyaknya, semakin kecil angka peroksida maka kualitas minyak semakin baik, bilangan iod yang tinggi menunjukkan bahwa minyak tersebut mengandung asam lemak tak jenuh yang banyak, semakin besar bilangan penyabunan yang dihasilkan maka minyak memiliki berat molekul yang lebih rendah. Hasil analisis minyak ikan dengan GC-MS didapat komposisi asam lemak sebagai berikut: asam lemak jenuh sebanyak 27,54%, asam lemak tidak jenuh tunggal sebanyak 43,92%, asam lemak tidak jenuh jamak sebanyak 21,25%. Asam lemak omega 3 sebanyak 2,83% yang terdiri dari asam linolenat 1,49%, asam eikosatrienoat 0,87%, asam eikosapentaenoat 0,11%, asam dekosaheksaenoat 0,36%, dan omega 6 sebanyak 17,36% yang terdiri dari asam linoleat 16,44%, asam arakhidonat 0,92%, Nilai gizi minyak ikan mas belum memenuhi komposisi ideal nilai gizi minyak ikan, dimana perbandingan ketiga jenis asam lemak belum memenuhi perbandingan 33,33% dan total penyimpangan sangat tinggi.
This study aimed to determine the components of omega-3 and omega-6 fatty acids in carp oil. This research was conducted at the Food Processing Laboratory of the Faculty of Agriculture, Santo Thomas Catholic University, Medan. The implementation of this research was conducted from August 2016 to October 2016. Carp oil was obtained using a dry rendering process. From the test of physical chemical properties obtained, the greater the value of the acid number, the lower the quality of the oil. It also showed that the smaller the peroxide number, the better the quality of the oil. The higher iodine number indicated that it contained many unsaturated fatty acids; therefore, the greater the saponification number the oil resulted, the lower molecular weight it obtained. The results of analysis of fish oil with GC-MS, showed the following fatty acid compositions: 27.54% saturated fatty acids, 43.92% monounsaturated fatty acids, and 21.25% plural unsaturated fatty acids. Omega-3 fatty acids were 2.83% consisting of 1.49% linolenic acid, 0.87% eicosapenoic acid, 0.11% eicosapentaenoic acid, 0.36% decosahexaenoic acid. It also resulted 17.36% omega-6 consisted of from linoleic acid 16.44%, arachidonic acid 0.92%. The nutritional value of goldfish oil did not meet the ideal composition of nutritional value of fish oil, where the ratio of the three types of fatty acids had not met the ratio of 33.33% and the total deviation was very high.
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Youness, Eman R., Jihan S. Hussein, Amr M. M. Ibrahim, and Fatma E. Agha. "Flaxseed Oil Attenuates Monosodium Glutamate-Induced Brain Injury via Improvement of Fatty Acids Contents." Biomedical and Pharmacology Journal 12, no. 2 (May 15, 2019): 527–32. http://dx.doi.org/10.13005/bpj/1671.
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Monosodium glutamate (MSG) is immensely globally used as a food aroma and additive, several studies indicated its toxicity in different body organs. Here, we aimed to evaluate brain dysfunctions in experimental animal that administered MSG and appreciate the beneficial role of flaxseed oil in attenuating this effect. In this study, forty male Wistar albino rats were divided into four groups; control, flaxseed oil, MSG and treated groups. Kidney and liver functions were estimated, malondialdehyde (MDA) and paraoxonase (PON1) were measured by colorimetric methods. Blood fatty acids and neurotransmitters parameters were estimated by HPLC. Our results revealed that MSG administration significantly increased oxidative stress and omega-6 fatty acids and decreased brain neurotransmitters as well as omega-3 fatty acids (ω-3 FA). Whereas treatment with flaxseed oil significantly attenuated all these disadvantages. The results of this study indicated that MSG was responsible for brain dysfunction that appeared in disturbances of neurotransmitters levels. In addition , the administration of omega-3 fatty acids in treated group effectively attenuated this dysfunctions through replacing omega-6 fatty acids in the neurocells by omega-3 fatty acids that represent in our study by flaxseed oil.
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Amjad Khan, Waleed, Hu Chun-Mei, Nadeem Khan, Amjad Iqbal, Shan-Wu Lyu, and Farooq Shah. "Bioengineered Plants Can Be a Useful Source of Omega-3 Fatty Acids." BioMed Research International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/7348919.
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Omega-3 fatty acids have proven to be very essential for human health due to their multiple health benefits. These essential fatty acids (EFAs) need to be uptaken through diet because they are unable to be produced by the human body. These are important for skin and hair growth as well as for proper visual, neural, and reproductive functions of the body. These fatty acids are proven to be extremely vital for normal tissue development during pregnancy and infancy. Omega-3 fatty acids can be obtained mainly from two dietary sources: marine and plant oils. Eicosapentaenoic acid (EPA; C20:5 n-3) and docosahexaenoic acid (DHA; C22:6 n-3) are the primary marine-derived omega-3 fatty acids. Marine fishes are high in omega-3 fatty acids, yet high consumption of those fishes will cause a shortage of fish stocks existing naturally in the oceans. An alternative source to achieve the recommended daily intake of EFAs is the demand of today. In this review article, an attempt has, therefore, been made to discuss the importance of omega-3 fatty acids and the recent developments in order to produce these fatty acids by the genetic modifications of the plants.
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Anne, Sirisha, Aruna Menon, and Sameena Parikh. "Role of omega 3 fatty acids on pregnancy outcome." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 12 (November 23, 2017): 5396. http://dx.doi.org/10.18203/2320-1770.ijrcog20175249.
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Background: Maternal nutrition plays a crucial role on influencing fetal growth and birth outcome. Any nutritional insult during critical periods of gestation is known to influence fetal development and increases the risk for development of diseases in later life. Omega 3 and omega 6 fatty acids have been studied to effect fetal growth and development. The balance between these two fatty acids have a definite effect on fetal growth and duration of gestation. Dietary intake of omega 3 fatty acids is less as compared to omega 6 fatty acids due to varied dietary sources.Methods: A study was conducted at a tertiary care hospital to study the pregnancy outcome in terms of neonatal birth weight and duration of gestation. A total of 200 patients were recruited into the study and divided into two groups by randomised alternative method. One group of 100 patients were supplemented with Omega 3 fatty acids and the other group was not supplemented. Both groups were followed till delivery and their duration of gestation and neonatal birth weight were studied and analysed.Results: The study showed that 78.8% patients supplemented with omega 3 fatty acids achieved neonatal birth weight more than 2.5Kg compared to 50% of patients who were not supplemented. No significant difference on duration of gestation was found in both the groups.Conclusions: Supplementation of Omega 3 fatty acids to patients in our study has shown to increase neonatal birth weight compared to patients who have not been supplemented, and did not show any significance in prolonging duration of gestation.