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1

Akeret, Kevin, David Bellut, Hans-Jürgen Huppertz, et al. "Ultrasonographic features of focal cortical dysplasia and their relevance for epilepsy surgery." Neurosurgical Focus 45, no. 3 (2018): E5. http://dx.doi.org/10.3171/2018.6.focus18221.

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OBJECTIVESurgery has proven to be the best therapeutic option for drug-refractory cases of focal cortical dysplasia (FCD)–associated epilepsy. Seizure outcome primarily depends on the completeness of resection, rendering the intraoperative FCD identification and delineation particularly important. This study aims to assess the diagnostic yield of intraoperative ultrasound (IOUS) in surgery for FCD-associated drug-refractory epilepsy.METHODSThe authors prospectively enrolled 15 consecutive patients with drug-refractory epilepsy who underwent an IOUS-assisted microsurgical resection of a radiolo
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Seong, Min Jae, Su Jung Choi, Eun Yeon Joo, et al. "Surgical outcome and prognostic factors in epilepsy patients with MR-negative focal cortical dysplasia." PLOS ONE 16, no. 4 (2021): e0249929. http://dx.doi.org/10.1371/journal.pone.0249929.

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Objective Focal cortical dysplasia (FCD) represents a heterogeneous group of disorders of the cortical formation and is one of the most common causes of epilepsy. Magnetic resonance imaging (MRI) is the modality of choice for detecting structural lesions, and the surgical prognosis in patients with MR lesions is favorable. However, the surgical prognosis of patients with MR-negative FCD is unknown. We aimed to evaluate the long-term surgical outcomes and prognostic factors in MR-negative FCD patients through comprehensive presurgical data. Methods We retrospectively reviewed data from 719 drug
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Li, Chao, Mingyang Li, and Yingchang Li. "Improving estimation of forest aboveground biomass using Landsat 8 imagery by incorporating forest crown density as a dummy variable." Canadian Journal of Forest Research 50, no. 4 (2020): 390–98. http://dx.doi.org/10.1139/cjfr-2019-0216.

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Optical remote sensing data are widely used in estimation of forest aboveground biomass (AGB), and the accuracy of AGB estimations has drawn wide attention. A method to improve the accuracy of remote sensing-based AGB models was developed by combining Landsat 8’s Operational Land Imager (OLI) and forest crown density (FCD). Remote sensing-based AGB models with and without an FCD dummy variable were developed using linear regression based on vegetation type (coniferous forest, broadleaf forest, mixed forest, and total vegetation). The differences between the models with and without an FCD dummy
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Houbraken, Maarten, Steven Logghe, Marco Schreuder, Pieter Audenaert, Didier Colle, and Mario Pickavet. "Automated Incident Detection Using Real-Time Floating Car Data." Journal of Advanced Transportation 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/8241545.

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The aim of this paper is to demonstrate the feasibility of a live Automated Incident Detection (AID) system using only Floating Car Data (FCD) in one of the first large-scale FCD AID field trials. AID systems detect traffic events and alert upcoming drivers to improve traffic safety without human monitoring. These automated systems traditionally rely on traffic monitoring sensors embedded in the road. FCD allows for finer spatial granularity of traffic monitoring. However, low penetration rates of FCD probe vehicles and the data latency have historically hindered FCD AID deployment. We use a l
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Pennington, Catherine, Harriet Ball, Marta Swirski, Margaret Newson, and Elizabeth Coulthard. "Metacognitive Performance on Memory and Visuospatial Tasks in Functional Cognitive Disorder." Brain Sciences 11, no. 10 (2021): 1368. http://dx.doi.org/10.3390/brainsci11101368.

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Functional Cognitive Disorder (FCD) is a common diagnosis at the memory clinic. FCD is characterised by significant self-reported cognitive symptoms in the absence of external evidence of cognitive dysfunction. A potential explanation for this is a deficit in metacognition, the process by which we internally judge our own abilities. Here we investigated differences in accuracy, confidence, and metacognition between people with FCD (N = 20), neurodegenerative mild cognitive impairment (nMCI; N = 14), and healthy controls (N = 23). The groups were assessed on forced choice memory and perceptual
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Larner, Andrew J. "Functional Cognitive Disorders (FCD): How Is Metacognition Involved?" Brain Sciences 11, no. 8 (2021): 1082. http://dx.doi.org/10.3390/brainsci11081082.

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Functional cognitive disorders (FCD) have become a subject of increasing clinical interest in recent years, in part because of their high prevalence amongst patients attending dedicated memory clinics. Empirical understanding of FCD based on observational studies is growing, suggesting a relationship to other functional neurological disorders (FND) based on shared phenomenology. However, understanding of FCD at the theoretical level has been lacking. One suggestion has been that FCD are disorders of metacognition, most usually of metamemory. In this article, a brief overview of these construct
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Zhao, Hui. "Improved Floyd Route Mending Algorithm Based on Dynamic Travel Time Applied to the Estimation of Floating Car Origin-Destination Data." Applied Mechanics and Materials 361-363 (August 2013): 2196–200. http://dx.doi.org/10.4028/www.scientific.net/amm.361-363.2196.

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The floating car data (FCD) is widely used to estimate the time-varying OD demands in recent years. The one of the most important factors influencing the application performance of FCD is the completeness of FCD route data. This paper is intended to develop Floyd route mending algorithm based on dynamic travel time for FCD. In this framework, the raw FCD and the processed FCD are used to identify the problem of data missing based on topological structure of the road network. Then, an approach is developed to mend route based on improved Floyd route mending algorithm based on the GIS map. The a
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Gross, Donald W., Alexandre Bastos, and Christian Beaulieu. "Diffusion Tensor Imaging Abnormalities in Focal Cortical Dysplasia." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 32, no. 4 (2005): 477–82. http://dx.doi.org/10.1017/s0317167100004479.

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ABSTRACT:Purpose:Focal cortical dysplasia (FCD) is one of the most common underlying pathologic substrates in patients with medically intractable epilepsy. While magnetic resonance imaging (MRI) evidence of FCD is an important predictor of good surgical outcome, conventional MRI is not sensitive enough to detect all lesions. Previous reports of diffusion tensor imaging (DTI) abnormalities in FCD suggest the potential of DTI in the detection of FCD. The purpose of this study was to study subcortical white matter underlying small lesions of FCD using DTI.Methods:Five patients with medically intr
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Giulioni, Marco, Gianluca Marucci, Matteo Martinoni, et al. "Seizure outcome in surgically treated drug-resistant mesial temporal lobe epilepsy based on the recent histopathological classifications." Journal of Neurosurgery 119, no. 1 (2013): 37–47. http://dx.doi.org/10.3171/2013.3.jns122132.

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Object The study was performed to investigate the relation between seizure outcome after surgical treatment of mesial temporal lobe epilepsy (MTLE) and pathological findings, classified according to the recently proposed classifications of mesial temporal sclerosis (MTS), granule cell pathology (GCP), focal cortical dysplasia (FCD) and epilepsy-associated low-grade tumors (ELGT). Methods The authors analyzed data obtained in 120 consecutive cases involving patients presenting with drug-resistant MTLE, who underwent tailored anteromesial temporal lobe resection, and correlated seizure outcome w
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Altintasi, Oruc, Hediye Tuydes-Yaman, and Kagan Tuncay. "A METHOD TO ESTIMATE TRAFFIC PENETRATION RATES OF COMMERCIAL FLOATING CAR DATA USING SPEED INFORMATION." Transport 37, no. 3 (2022): 161–76. http://dx.doi.org/10.3846/transport.2022.17069.

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Floating Car Data (FCD) are being increasingly used as an alternative traffic data source due to its lower cost and high coverage area. FCD can be obtained by tracking vehicle trajectories individually or by processing multiple tracks anonymously to produce average speed information commercially. For commercial FCD, the spatio-temporal distribution of these vehicles in actual traffic, traffic Penetration Rate (PR) is the most important factor affecting the accuracy of speed estimations, despite the high number of registered vehicles feeding to an FCD provider, denoting the market PR. This stud
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Lee, Wei Shern, Sara Baldassari, Sarah E. M. Stephenson, Paul J. Lockhart, Stéphanie Baulac, and Richard J. Leventer. "Cortical Dysplasia and the mTOR Pathway: How the Study of Human Brain Tissue Has Led to Insights into Epileptogenesis." International Journal of Molecular Sciences 23, no. 3 (2022): 1344. http://dx.doi.org/10.3390/ijms23031344.

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Type II focal cortical dysplasia (FCD) is a neuropathological entity characterised by cortical dyslamination with the presence of dysmorphic neurons only (FCDIIA) or the presence of both dysmorphic neurons and balloon cells (FCDIIB). The year 2021 marks the 50th anniversary of the recognition of FCD as a cause of drug resistant epilepsy, and it is now the most common reason for epilepsy surgery. The causes of FCD remained unknown until relatively recently. The study of resected human FCD tissue using novel genomic technologies has led to remarkable advances in understanding the genetic basis o
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MacLean, MA, AS Easton, and GE Pickett. "P.034 Focal cortical dysplasia type IIIb associated with oligodendroglioma in a seizure free patient: a case report." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 44, S2 (2017): S22. http://dx.doi.org/10.1017/cjn.2017.119.

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Background: Focal cortical dysplasia (FCD) refers to malformation of cortical development featuring abnormalities of cortical layering, neuronal differentiation and maturation. It is a common cause of medically refractory epilepsy. The coexistence of FCD and low-grade glial neoplasms such as ganglioglioma and dysembryoplastic neuroepithelial tumour is classified by the International League Against Epilepsy as “FCD Type IIIb”. We present a case of FCD Type IIIb associated with low grade oligodendroglioma (WHO grade II) in a seizure free patient. Methods: A 20-year-old male presented with suspec
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Knerlich-Lukoschus, Friederike, Mary B. Connolly, Glenda Hendson, Paul Steinbok, and Christopher Dunham. "Clinical, imaging, and immunohistochemical characteristics of focal cortical dysplasia Type II extratemporal epilepsies in children: analyses of an institutional case series." Journal of Neurosurgery: Pediatrics 19, no. 2 (2017): 182–95. http://dx.doi.org/10.3171/2016.8.peds1686.

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OBJECTIVE Focal cortical dysplasia (FCD) Type II is divided into 2 subgroups based on the absence (IIA) or presence (IIB) of balloon cells. In particular, extratemporal FCD Type IIA and IIB is not completely understood in terms of clinical, imaging, biological, and neuropathological differences. The aim of the authors was to analyze distinctions between these 2 formal entities and address clinical, MRI, and immunohistochemical features of extratemporal epilepsies in children. METHODS Cases formerly classified as Palmini FCD Type II nontemporal epilepsies were identified through the prospective
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Kapar, Ozge, Zahide Mail Gurkan, Muge Dolgun, Altay Sencer, Candan Gürses, and Bilge Bilgic. "Focal cortical dysplasia pathology: diagnostic difficulty, classification, and utility for pathogenesis." Neurosurgical Focus 53, no. 4 (2022): E6. http://dx.doi.org/10.3171/2022.7.focus21731.

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OBJECTIVE In the histopathological examination of treatment-resistant epilepsy, focal cortical dysplasia (FCD) is the most common diagnosis in the pediatric group. FCD is classified histopathologically according to the International League Against Epilepsy (ILAE) classification. In the last decade since the ILAE classification has been released, molecular genetic studies have revealed mTOR pathway–related mutations as a major etiology. The objective of this study was to determine the incidence of FCD in treatment-resistant epilepsy patients, explore histomorphological and immunohistochemical f
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Dehghan, Melody, Gabriel Wong, Eddie Neuberger, Cindy Kin, Florian Rieder, and K. T. Park. "Worse outcomes and higher costs of care in fibrostenotic Crohn’s disease: a real-world propensity-matched analysis in the USA." BMJ Open Gastroenterology 8, no. 1 (2021): e000781. http://dx.doi.org/10.1136/bmjgast-2021-000781.

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BackgroundPatients with Crohn’s disease (CD) may develop fibrostenotic strictures. No currently available therapies prevent or treat fibrostenotic CD (FCD), making this a critical unmet need.AimTo compare health outcomes and resource utilisation between CD patients with and without fibrostenotic disease.MethodsPatients aged ≥18 years with FCD and non-FCD between 30 October 2015 and 30 September 2018 were identified in the Truven MarketScan Commercial Claims and Encounters Database. We conducted 1:3 nearest neighbour propensity score matching on age, sex, malnutrition, payer type, anti-tumour n
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Ball, Harriet A., Marta Swirski, Margaret Newson, Elizabeth J. Coulthard, and Catherine M. Pennington. "Differentiating Functional Cognitive Disorder from Early Neurodegeneration: A Clinic-Based Study." Brain Sciences 11, no. 6 (2021): 800. http://dx.doi.org/10.3390/brainsci11060800.

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Functional cognitive disorder (FCD) is a relatively common cause of cognitive symptoms, characterised by inconsistency between symptoms and observed or self-reported cognitive functioning. We aimed to improve the clinical characterisation of FCD, in particular its differentiation from early neurodegeneration. Two patient cohorts were recruited from a UK-based tertiary cognitive clinic, diagnosed following clinical assessment, investigation and expert multidisciplinary team review: FCD, (n = 21), and neurodegenerative Mild Cognitive Impairment (nMCI, n = 17). We separately recruited a healthy c
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Urbach, Horst, Marcel Heers, Dirk-Matthias Altenmueller, et al. "“Within a minute” detection of focal cortical dysplasia." Neuroradiology 64, no. 4 (2021): 715–26. http://dx.doi.org/10.1007/s00234-021-02823-7.

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Abstract Purpose To evaluate a MRI postprocessing tool for the enhanced and rapid detection of focal cortical dysplasia (FCD). Methods MP2RAGE sequences of 40 consecutive, so far MRI-negative patients and of 32 healthy controls were morphometrically analyzed to highlight typical FCD features. The resulting morphometric maps served as input for an artificial neural network generating a FCD probability map. The FCD probability map was inversely normalized, co-registered to the MPRAGE2 sequence, and re-transferred into the PACS system. Co-registered images were scrolled through “within a minute”
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Bitar, Mireille, Yevgen Chornenkyy, Margaret E. Flanagan, Alicia Steffens, Kathleen McCortney, and Craig Horbinski. "The Frequency of Focal Cortical Dysplasia-Like Histologic Features Near Adult-Type Diffuse Gliomas." Journal of Neuropathology & Experimental Neurology 81, no. 1 (2021): 48–53. http://dx.doi.org/10.1093/jnen/nlab120.

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Abstract While the coexistence of focal cortical dysplasia (FCD) and grade 1 noninfiltrative gliomas has been described, to date, only rare case reports have described FCD adjacent to infiltrating gliomas. We therefore sought to determine how often FCD-like findings occur near adult-type diffuse gliomas. This was a retrospective survey of 186 consecutive, newly diagnosed, en bloc glioma resections. Fifty-nine (31.7%) had sufficient adjacent cortex to evaluate for FCD-like features. Among IDH mutant (“IDHmut”) gliomas, 40/77 (52%) had adjacent evaluable cortex, whereas only 19/109 (17%) of IDH
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Lv, Xiao-Fei, Hua-Wang Wu, Li Tian, et al. "Aberrant Resting-State Functional Connectivity Density in Patients with Hepatitis B Virus-Related Cirrhosis." BioMed Research International 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/4168512.

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There is increasing evidence that cirrhosis may affect functional connectivity among various brain regions in patients prior to onset of overt hepatic encephalopathy (HE). However, most investigators have focused mainly on alterations in functional connectivity strengths, and the changes in functional connectivity density (FCD) are largely unknown. Here, we investigated alterations in resting-state FCD in patients with hepatitis B virus-related cirrhosis (HBV-RC) without overt HE. Totally, 31 patients with HBV-RC without overt HE and 30 age- and sex-matched healthy controls underwent resting-s
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Dührsen, Lasse, Thomas Sauvigny, Patrick M. House, et al. "Impact of focal cortical dysplasia Type IIIa on seizure outcome following anterior mesial temporal lobe resection for the treatment of epilepsy." Journal of Neurosurgery 128, no. 6 (2018): 1668–73. http://dx.doi.org/10.3171/2017.2.jns161295.

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OBJECTIVETemporal lobe epilepsy (TLE) is the most common type of pharmacoresistant focal epilepsy, for which anterior mesial temporal lobe resection (AMTLR) is a treatment option. Focal cortical dysplasia Type IIIa (FCD IIIa), a developmental lesion resulting from defects in neuronal formation and migration into the temporal pole (FCD I) combined with hippocampal sclerosis (HS), can be a neuropathological finding. In this study, the authors investigate the impact of FCD IIIa on seizure outcome in patients with TLE who underwent AMTLR.METHODSThe authors performed a retrospective analysis of all
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Kim, Sangho, Aleksander S. Popel, Marcos Intaglietta, and Paul C. Johnson. "Effect of erythrocyte aggregation at normal human levels on functional capillary density in rat spinotrapezius muscle." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 3 (2006): H941—H947. http://dx.doi.org/10.1152/ajpheart.00645.2005.

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Previous studies have shown that functional capillary density (FCD) is substantially reduced by erythrocyte aggregation. However, only supranormal levels of aggregability were studied. To investigate the effect of erythrocyte aggregability at the level seen in healthy humans, the FCD of selected capillary fields in rat spinotrapezius muscle was determined with high-speed video microscopy under normal (nonaggregating) conditions and after induction of erythrocyte aggregation with Dextran 500 (200 mg/kg). To examine shear rate dependence, the effect was studied both at normal and reduced arteria
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Krochmalnek, E., A. Accogli, J. St-Onge, et al. "P.048 Characterization of somatic mutations in mTOR pathway genes in focal cortical dysplasias." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 46, s1 (2019): S26—S27. http://dx.doi.org/10.1017/cjn.2019.148.

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Background: Focal cortical dysplasias (FCDs) are congenital structural abnormalities of the brain, and represent the most common cause of medication-resistant focal epilepsy in children and adults. Recent studies have shown that somatic mutations (i.e. mutations arising in the embryo) in mTOR pathway genes underlie some FCD cases. Specific therapies targeting the mTOR pathway are available. However, testing for somatic mTOR pathway mutations in FCD tissue is not performed on a clinical basis, and the contribution of such mutations to the pathogenesis of FCD remains unknown. Aim: To investigate
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Bell, Simone, Heikki Pakkala, and Michael P. Finglas. "Towards a European Food Composition Data Interchange Platform." International Journal for Vitamin and Nutrition Research 82, no. 3 (2012): 209–15. http://dx.doi.org/10.1024/0300-9831/a000113.

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Food composition data (FCD) comprises the description and identification of foods, as well as their nutrient content, other constituents, and food properties. FCD are required for a range of purposes including food labeling, supporting health claims, nutritional and clinical management, consumer information, and research. There have been differences within and beyond Europe in the way FCD are expressed with respect to food description, definition of nutrients and other food properties, and the methods used to generate data. One of the major goals of the EuroFIR NoE project (2005 - 10) was to p
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Urbach, Horst, Elias Kellner, Nico Kremers, Ingmar Blümcke, and Theo Demerath. "MRI of focal cortical dysplasia." Neuroradiology 64, no. 3 (2021): 443–52. http://dx.doi.org/10.1007/s00234-021-02865-x.

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AbstractFocal cortical dysplasia (FCD) are histopathologically categorized in ILAE type I to III. Mild malformations of cortical development (mMCD) including those with oligodendroglial hyperplasia (MOGHE) are to be integrated into this classification yet. Only FCD type II have distinctive MRI and molecular genetics alterations so far. Subtle FCD including FCD type II located in the depth of a sulcus are often overlooked requiring the use of dedicated sequences (MP2RAGE, FLAWS, EDGE) and/or voxel (VBM)- or surface-based (SBM) postprocessing. The added value of 7 Tesla MRI has to be proven yet.
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Nishimura, Yorihiro, Masayuki Shimojima, Eiji Sato та ін. "Downmodulation of CD3ε expression in CD8α + β − T cells of feline immunodeficiency virus-infected cats". Journal of General Virology 85, № 9 (2004): 2585–89. http://dx.doi.org/10.1099/vir.0.80102-0.

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Feline immunodeficiency virus (FIV) infection in cats is associated with an increase of feline CD (fCD)8α + β − and fCD8α + β low cells in peripheral blood. To investigate these cells in more detail, an anti-fCD3ε mAb, termed NZM1, was generated, which recognizes the extracellular epitope of the fCD3ε molecule. The anti-fCD3ε mAb proved to be more suitable for identifying feline T cells than the anti-fCD5 one, which has been used as a pan-T-cell reagent in cats, because of the presence of fCD5+fCD3ε − cells among lymphocytes. Although the fCD8α + β − and fCD8α + β low cells in the FIV-infected
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Zhang, Yu, Yongzhe Fan, Xue Zhao, et al. "Influence of Graphite Morphology on Phase, Microstructure, and Properties of Hot Dipping and Diffusion Aluminizing Coating on Flake/Spheroidal Graphite Cast Iron." Metals 9, no. 4 (2019): 450. http://dx.doi.org/10.3390/met9040450.

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The influence of graphite morphology on the phase, microstructure and properties of hot dipping and diffusion aluminizing (HDDA) coating on flake/spheroidal graphite cast iron (FC/FCD) was investigated. The microstructure and properties of the HDDA coatings on FC/FCD were determined by the graphite morphology. The outer and inner layers of the HDDA coating comprised the Fe2Al5 and FeAl phases, respectively. The outer layer of HDDA on FCD was dense and uniform; however, some pores of different sizes were found in the outer coating on FC, resulting in looser HDDA coating. Hence, the wear resista
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Reed, Nicholas S., Jennifer A. Deal, Matthew G. Huddle, et al. "Pilot Study of Audiometric Patterns in Fuchs Corneal Dystrophy." Journal of Speech, Language, and Hearing Research 61, no. 10 (2018): 2604–8. http://dx.doi.org/10.1044/2018_jslhr-h-18-0088.

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Purpose Although Fuchs corneal dystrophy (FCD) is considered an eye disease, a small number of studies have identified genes related to both FCD and hearing loss. Whether FCD is related to hearing loss is unknown. Method This is a case–control study comparing pure-tone audiometry hearing thresholds in 180 patients with FCD from a hospital-based ophthalmology clinic with 2,575 population-based controls from a nationally representative survey, the National Health and Nutrition Examination Survey (from cycles 2005-06 and 2009-10). Generalized estimating equations were used to compare mean better-
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Sonawane, Kishor, and Vijay Bhagat. "Improved Change Detection of Forests Using Landsat TM and ETM data." Remote Sensing of Land 1, no. 1 (2016): 18–40. http://dx.doi.org/10.21523/gcj1.17010102.

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Landsat TM and ETM+ datasets are useful for forest change detection (FCD) at good accuracy level. Classified forest maps have been prepared using NDVI calculated from Landsat-5 TM (2009) and Landsat-7 ETM+ (2002) datasets for FCD using post-classification technique. About 58.59% of reviewed area shows positive changes, 33.69% no-changes and 7.72% negative changes with 77.84% accuracy. This accuracy insists limitations of present FCD analysis. Therefore, improved post-classification technique was formulated for precise FCD using field data and statistical techniques. Information about stable la
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Wetwittayakhlang, Panu, Alex Al Khoury, Gustavo Drügg Hahn, and Peter Laszlo Lakatos. "The Optimal Management of Fistulizing Crohn’s Disease: Evidence beyond Randomized Clinical Trials." Journal of Clinical Medicine 11, no. 11 (2022): 3045. http://dx.doi.org/10.3390/jcm11113045.

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Fistulizing Crohn’s disease (FCD) remains the most challenging aspect of treating patients with CD. FCD can occur in up to 30% of patients with CD and may lead to significant disability and impaired quality of life. The optimal treatment strategies for FCD require a multidisciplinary approach, including a combined medical and surgical approach. The therapeutic options for FCD are limited due to sparse evidence from randomized clinical trials (RCTs). The current recommendations are mainly based on post hoc analysis from RCTs, real-world clinical studies and expert opinion. There is variation in
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Hamadeh, Abdullah, Brian Ingalls, and Eduardo Sontag. "Transient dynamic phenotypes as criteria for model discrimination: fold-change detection in Rhodobacter sphaeroides chemotaxis." Journal of The Royal Society Interface 10, no. 80 (2013): 20120935. http://dx.doi.org/10.1098/rsif.2012.0935.

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The chemotaxis pathway of the bacterium Rhodobacter sphaeroides shares many similarities with that of Escherichia coli . It exhibits robust adaptation and has several homologues of the latter's chemotaxis proteins. Recent theoretical results have correctly predicted that the E. coli output behaviour is unchanged under scaling of its ligand input signal; this property is known as fold-change detection (FCD). In the light of recent experimental results suggesting that R. sphaeroides may also show FCD, we present theoretical assumptions on the R. sphaeroides chemosensory dynamics that can be show
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Altintasi, Oruc, Hediye Tuydes-Yaman, and Kagan Tuncay. "Quality of floating car data (FCD) as a surrogate measure for urban arterial speed." Canadian Journal of Civil Engineering 46, no. 12 (2019): 1187–98. http://dx.doi.org/10.1139/cjce-2018-0422.

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Commercial floating car data (FCD) is being increasingly used as a traffic data source due to its lower cost despite concerns about its reliability. This paper focuses on the evaluation of FCD speed quality as a surrogate measure for arterial speed from different aspects. First, FCD speed is compared to video-based traffic data, collected from a specific urban road segment and assumed as ground truth in (a) descriptive evaluations, (b) speed estimation, and (c) level of service estimation. Regression analysis carried out to derive transformation function between two datasets showed a nonlinear
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Sacino, Matthew F., Cheng-Ying Ho, Jonathan Murnick, et al. "Intraoperative MRI–guided resection of focal cortical dysplasia in pediatric patients: technique and outcomes." Journal of Neurosurgery: Pediatrics 17, no. 6 (2016): 672–78. http://dx.doi.org/10.3171/2015.10.peds15512.

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OBJECTIVE Previous meta-analysis has demonstrated that the most important factor in seizure freedom following surgery for focal cortical dysplasia (FCD) is completeness of resection. However, intraoperative detection of epileptogenic dysplastic cortical tissue remains a challenge, potentially leading to a partial resection and the need for reoperation. The objective of this study was to determine the role of intraoperative MRI (iMRI) in the intraoperative detection and localization of FCD as well as its impact on surgical decision making, completeness of resection, and seizure control outcomes
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Chen, Shang-Der, Hsiu-Yung Pan, Jyun-Bin Huang, et al. "Circulating MicroRNAs from Serum Exosomes May Serve as a Putative Biomarker in the Diagnosis and Treatment of Patients with Focal Cortical Dysplasia." Cells 9, no. 8 (2020): 1867. http://dx.doi.org/10.3390/cells9081867.

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Focal cortical dysplasia (FCD) is a congenital malformation of cortical development where the cortical neurons located in the brain area fail to migrate in the proper formation. Epilepsy, particularly medically refractory epilepsy, is the most common clinical presentation for all types of FCD. This study aimed to explore the expression change of circulating miRNAs in patients with FCD from serum exosomes. A total of nine patients with FCD and four healthy volunteers were enrolled in this study. The serum exosomes were isolated from the peripheral blood of the subjects. Transmission electron mi
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Willard, Anna, Ana Antonic-Baker, Zhibin Chen, Terence John O'Brien, Patrick Kwan, and Piero Perucca. "Seizure Outcome After Surgery for MRI-Diagnosed Focal Cortical Dysplasia." Neurology 98, no. 3 (2021): e236-e248. http://dx.doi.org/10.1212/wnl.0000000000013066.

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Background and ObjectivesFocal cortical dysplasia (FCD) has been associated with poorer postsurgical seizure outcomes compared to other pathologies. FCD surgical series have been assembled on the basis of a histologic diagnosis, including patients with abnormal and normal preoperative MRI. However, in clinical workflow, patient selection for surgery is based on preoperative findings, including MRI. We performed a systematic review and meta-analysis of the literature to determine the rate and predictors of favorable seizure outcome after surgery for MRI-detected FCD.MethodsWe devised our study
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Mathon, Bertrand, Stéphane Clemenceau, and Alexandre Carpentier. "Intraoperative Ultrasound Shear-Wave Elastography in Focal Cortical Dysplasia Surgery." Journal of Clinical Medicine 10, no. 5 (2021): 1049. http://dx.doi.org/10.3390/jcm10051049.

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Previous studies reported interest in intraoperative shear-wave elastography (SWE) guidance for brain-tumor and epilepsy surgeries. Focal cortical dysplasia (FCD) surgery is one of the most appropriate indications for using SWE guidance. The aim of this study was to evaluate the efficacy of ultrasound SWE techniques for the intraoperative detection of FCDs. We retrospectively analyzed data from 18 adult patients with drug-resistant epilepsy associated with FCD who had undergone SWE-guided surgery. Conventional B-mode images detected FCD in 2 patients (11.1%), while SWE detected FCD in 14 patie
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Liu, Tao, Jianjun Li, Zhiqiang Zhang, et al. "Altered Long- and Short-Range Functional Connectivity in Patients with Betel Quid Dependence: A Resting-State Functional MRI Study." Cellular Physiology and Biochemistry 40, no. 6 (2016): 1626–36. http://dx.doi.org/10.1159/000453212.

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Objective: Addiction is a chronic relapsing brain disease. Brain structural abnormalities may constitute an abnormal neural network that underlies the risk of drug dependence. We hypothesized that individuals with Betel Quid Dependence (BQD) have functional connectivity alterations that can be described by long- and short-range functional connectivity density(FCD) maps. Methods: We tested this hypothesis using functional magnetic resonance imaging (fMRI) data from subjects of the Han ethnic group in Hainan, China. Here, we examined BQD individuals (n = 33) and age-, sex-, and education-matched
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Cabrales, Pedro, Amy G. Tsai, Robert M. Winslow, and Marcos Intaglietta. "Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 5 (2005): H2146—H2153. http://dx.doi.org/10.1152/ajpheart.00749.2004.

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A surface-modified polyethylene glycol-conjugated human hemoglobin (MP4) and αα-cross-linked human hemoglobin (ααHb) were used to restore oxygen carrying capacity in conditions of extreme hemodilution (hematocrit 11%) in the hamster window model preparation. Changes in microvascular function were analyzed in terms of effects on capillary pressure and functional capillary density (FCD). MP4, at 1.0 ± 0.2 g/dl blood concentration, significantly lowered mean arterial pressure (MAP) below baseline (99.6 ± 7.6 mmHg) to 82.4 ± 6.9 mmHg ( P < 0.05) and decreased of FCD to 70 ± 9%. ααHb caused a gr
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Куликова, С. Л., С. Н. Рябцева, and С. А. Лихачев. "Focal Cortical Dysplasia: Evolution of Classification Systems." Неврология и нейрохирургия. Восточная Европа, no. 3 (November 11, 2021): 410–22. http://dx.doi.org/10.34883/pi.2021.11.3.053.

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Фокальная кортикальная дисплазия (ФКД) является наиболее частой причиной развития фармакорезистентной эпилепсии. По данным I. Blumcke и соавт., на долю ФКД приходится 14,1% случаев среди всех оперированных с эпилепсией. Впервые наличие аномальных дисморфных нейронов в коре головного мозга было описано L.D. Crome в 1957 г. Позднее, в1971 г., Taylor D.C. описал, помимо дисморфных нейронов, гигантские (в том числе «баллонные») нейроны, после чего впервые начал употребляться термин «фокальная кортикальная дисплазия». В 2004 г. Palmini et al. разработали классификацию, согласно которой аномалии стр
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Ajmar, A., E. Arco, P. Boccardo, and F. Perez. "FLOATING CAR DATA (FCD) FOR MOBILITY APPLICATIONS." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-2/W13 (June 5, 2019): 1517–23. http://dx.doi.org/10.5194/isprs-archives-xlii-2-w13-1517-2019.

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<p><strong>Abstract.</strong> Floating car data (FCD) is becoming more and more relevant for mobility domain applications, overcoming issues derived by the use of physical sensors (e.g. inductive loops, video observation, infrared and laser vehicle detection etc.), such as limited geographical distribution, measure inhomogeneities, limited or null coverage of minor roads. An increasing number of vehicles are equipped with devices capable of acquiring GPS positions and other data, transmitted in almost real-time to traffic control centres. Based on FCD data, several traffic an
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Wang, Xiaozhuan, Dabiao Deng, Chengqian Zhou, et al. "Focal Cortical Dysplasia Type Ⅲ Related Medically Refractory Epilepsy: MRI Findings and Potential Predictors of Surgery Outcome." Diagnostics 11, no. 12 (2021): 2225. http://dx.doi.org/10.3390/diagnostics11122225.

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This study aims to explore the relationship between neuropathologic and the post-surgical prognosis of focal cortical dysplasia (FCD) typed-Ⅲ-related medically refractory epilepsy. A total of 266 patients with FCD typed-Ⅲ-related medically refractory epilepsy were retrospectively studied. Presurgical clinical data, type of surgery, and postsurgical seizure outcome were analyzed. The minimum post-surgical follow-up was 1 year. A total of 266 patients of FCD type Ⅲ were included in this study and the median follow-up time was 30 months (range, 12~48 months). Age at onset ranged from 1.0 years to
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Topaloglu, Ilhan, Serhat Yaslikaya, and Güler Berkiten. "Facial canal dehiscence in patients undergoing surgery for chronic otitis media: analysis of 850 patients." Otolaryngologia Polska 77, no. 1 (2022): 1–5. http://dx.doi.org/10.5604/01.3001.0016.1772.

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ntroductionIn all otologic surgeries, the facial nerve can be considered the most important structure that must be protected. The surgical damage risk of the facial nerve will be increased in presence of facial canal dehiscence (FCD).AimIn this study, we aimed to evaluate the FCD and its associated situations in patients with chronic otitis media undergoing mastoidectomy.Materials and Methods850 patients who performed ear surgery were reviewed. Patients who did not perform mastoidectomy were excluded. In patients, the ratios, localization of FCD, and association of facial canal dehiscence with
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Nash, Alexandra, Jon Stone, Alan Carson, Craig Ritchie, and Laura McWhirter. "Use and understanding of functional cognitive disorder terminology in United Kingdom clinical practice - a survey." BJPsych Open 7, S1 (2021): S277. http://dx.doi.org/10.1192/bjo.2021.737.

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AimsThis study aimed to explore the terms used by old-age psychiatrists and psychologists to describe subjective and mild cognitive impairment and functional cognitive disorders (FCD) in clinical practice.MethodParticipants were selected from across the United Kingdom based on their clinical involvement in the assessment of cognitive complaints. 9 old-age psychiatrists and 4 psychologists were interviewed about their use of terminology in clinical practice and their awareness and understanding of FCD terminology via semi-structured interview questions and case vignettes. Interviews were conduc
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Xu, Yuan, Chen, and Ren. "Guided Wave-Convolutional Neural Network Based Fatigue Crack Diagnosis of Aircraft Structures." Sensors 19, no. 16 (2019): 3567. http://dx.doi.org/10.3390/s19163567.

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Fatigue crack diagnosis (FCD) is of great significance for ensuring safe operation, prolonging service time and reducing maintenance cost in aircrafts and many other safety-critical systems. As a promising method, the guided wave (GW)-based structural health monitoring method has been widely investigated for FCD. However, reliable FCD still meets challenges, because uncertainties in real engineering applications usually cause serious change both to the crack propagation itself and GW monitoring signals. As one of deep learning methods, convolutional neural network (CNN) owns the ability of fus
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Hoare, Samuel, Fiona Lithander, Ingrid van der Mei, et al. "Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: Results from the Ausimmune Study." Multiple Sclerosis Journal 22, no. 7 (2015): 884–92. http://dx.doi.org/10.1177/1352458515604380.

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Background: There is contradictory evidence for a role of dietary fat in risk of multiple sclerosis (MS). Objectives: To examine the association between usual fat intake (total, saturated, monounsaturated (MUFA), polyunsaturated (PUFA), omega-3 and omega-6) and risk of a first clinical diagnosis of CNS demyelination (FCD). Methods: Multi-centre incident case-control study in four regions of Australia during 2003–2006. Cases were aged 18–59 years and had a FCD; controls were matched to a case on age, sex and location. Dietary data were collected using a validated food frequency questionnaire. R
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Sahin, Muammer Melih, Melih Cayonu, Ayse Secil Kayalı Dinc, Suleyman Boynuegri, Fulya Eker Barut, and Adil Eryilmaz. "Cautionary Findings for the Presence of Facial Canal Dehiscence During Cholesteatoma Surgery." Ear, Nose & Throat Journal 99, no. 5 (2019): 327–30. http://dx.doi.org/10.1177/0145561319856886.

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Our aim was to investigate the relationship between facial canal dehiscence (FCD) and surgical findings and procedures in patients with cholesteatoma. A total of 186 patients (118 males, 39.2 ± 15 years) who underwent surgery for advanced cholesteatoma between 2013 and 2018 were included in the study. The relationship between FCD and surgical findings was investigated via the surgical registries. The prevalence of FCD was 36.6% (68/186). The prevalence of FCD was 44%, and 13.2% for the patients who underwent canal wall down mastoidectomy (62/141) and canal wall up mastoidectomy (6/45), respect
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Black, Lucinda J., Kimberley Baker, Anne-Louise Ponsonby, et al. "A Higher Mediterranean Diet Score, Including Unprocessed Red Meat, Is Associated with Reduced Risk of Central Nervous System Demyelination in a Case-Control Study of Australian Adults." Journal of Nutrition 149, no. 8 (2019): 1385–92. http://dx.doi.org/10.1093/jn/nxz089.

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ABSTRACT Background The evidence associating diet and risk of multiple sclerosis (MS) is inconclusive. Objectives The aim of this study was to investigate associations between a Mediterranean diet and risk of a first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to MS. Methods We used data from the 2003–2006 Ausimmune Study, an Australian multicenter, case-control study examining environmental risk factors for FCD, with participants matched on age, sex, and study region (282 cases, 558 controls; 18–59 y old; 78% female). The alternate Mediterranean diet s
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Ball, Harriet A., Marta Swirski, Margaret Newson, Elizabeth Coulthard, and Catherine Pennington. "14 Differentiating functional cognitive disorder from early neurodegeneration: a clinic-based study." Journal of Neurology, Neurosurgery & Psychiatry 91, no. 8 (2020): e13.1-e13. http://dx.doi.org/10.1136/jnnp-2020-bnpa.31.

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Objectives/AimsFunctional Cognitive Disorder (FCD) describes distressing or disabling cognitive symptoms that can be positively identified as internally inconsistent with recognised brain or systemic disease processes. FCD is common amongst attendees to cognitive or memory clinics. We aimed to improve the clinical characterisation of such patients, and identify means to differentiate them from patients with early neurodegeneration.MethodsWe identified two samples of patients recruited from a specialist cognitive clinic, classified on the basis of consensus expert clinical opinion following rel
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Idrovo, Alvaro J. "Physical environment and life expectancy at birth in Mexico: an eco-epidemiological study." Cadernos de Saúde Pública 27, no. 6 (2011): 1175–84. http://dx.doi.org/10.1590/s0102-311x2011000600014.

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The objective of this ecological study was to ascertain the effects of physical environment on life expectancy at birth, using data from all 32 Mexican states. 50 environmental indicators with information about demography, housing, poverty, water, soils, biodiversity, forestry resources, and residues were included in exploratory factor analysis. Four factors were extracted: population vulnerability/susceptibility, and biodiversity (FC1), urbanization, industrialization, and environmental sustainability (FC2), ecological resilience (FC3), and free-plague environments (FC4). Using OLS regression
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Phi, Ji Hoon, Byung-Kyu Cho, Kyu-Chang Wang, et al. "Longitudinal analyses of the surgical outcomes of pediatric epilepsy patients with focal cortical dysplasia." Journal of Neurosurgery: Pediatrics 6, no. 1 (2010): 49–56. http://dx.doi.org/10.3171/2010.3.peds09497.

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Object The long-term surgical outcome of pediatric patients with epilepsy accompanied by focal cortical dysplasia (FCD) is not clear. The authors report on the long-term surgical outcomes of children with FCD, based on longitudinal analyses. Methods The authors retrospectively analyzed the records of 41 children who underwent epilepsy surgery for pathologically proven FCD. Twenty of these patients were male and 21 were female. The median age at surgery was 9 years (range 1–17 years). Results The actuarial seizure-free rates were 49, 44, and 33% in the 1st, 2nd, and 5th years after surgery, res
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Zhilin, Evgeniy Vitalievich, Dmitriy Aleksandrovich Prasol, and Nikita Yurievich Savvin. "Optimization of the structure of filter-compensating devices in networks with powerful non-linear power consumers based on fuzzy logic." International Journal of Electrical and Computer Engineering (IJECE) 12, no. 6 (2022): 5730. http://dx.doi.org/10.11591/ijece.v12i6.pp5730-5737.

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<span lang="EN-US">The article presents a solution to the problem of optimizing the structure of filter-compensating devices (FCD) when installed in high-voltage mine networks with powerful nonlinear electrical receivers. The urgency of the problem of choosing a rational structure of the FCD. The problem of choosing the design and installation location of the FCD is presented. The main technical means of compensation of higher harmonics of currents and voltages in high-voltage networks with powerful nonlinear electrical receivers are considered. Analysis of different types of passive fil
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