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Dissertations / Theses on the topic 'FDA Approval'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Potthoff, Katharina. "FDA drug approval an analysis of the effects on stock prices /." St. Gallen, 2006. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/01665991002/$FILE/01665991002.pdf.

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2

Péladeau, Christine. "Utrophin A Upregulation by FDA-Approved Drugs for the Treatment of Duchenne Muscular Dystrophy." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39298.

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Duchenne Muscular Dystrophy (DMD) is a disorder caused by mutations in the dystrophin gene, preventing the production of the functional dystrophin protein which assures maintenance of the myofiber integrity throughout muscle contraction. A lack of dystrophin results in severe muscle degeneration and regeneration accompanied by a loss of muscle function. Many pre-clinical and clinical studies are focused on developing strategies to counteract the detrimental effects of DMD; however, there is no cure. One such approach consists of upregulating the endogenous protein utrophin A in dystrophic musc

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3

Witherspoon, Luke. "In Silico Mining of a System Wide Transcriptional Profiling Database for Clinically Relevant Gene Modulation by FDA Approved or FDA Ready Agents; Validation of a Novel Translational Approach." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20118.

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It has been recognized that small molecules can affect a substantial proportion of the human transcriptome in ways that are currently unknown and difficult to predict. Working with the Broad Institute, using their Connectivity Map database, we have worked to identify compounds anticipated to modulate two diseases; myotonic dystrophy (DM1) and Duchenne muscular dystrophy (DMD). DM1 stems from an expanded CTG repeat found in the DMPK gene. The down regulation of DMPK mRNA represents a valid therapeutic avenue. DMD is characterized by degeneration of muscle, caused by mutations in the dystrophin

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4

Johnstone, Andrea. "Overcoming Glial-Derived Inhibition of Regeneration in CNS Neurons: From Novel Compounds to Novel Uses for FDA-Approved Compounds." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/631.

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Trauma to the central nervous system (CNS) results in an irreversible disruption of axon tracts, often leading to lifelong functional deficits. Despite a large body of research into the mechanisms that underlie the lack of axonal regeneration after CNS injury, there are currently no effective treatments. One major obstacle involves the presence at injury sites of CNS growth-inhibitory molecules, such as myelin proteins and astrocyte-derived chondroitin sulfate proteoglycans (CSPGs), which act as environmental barriers to axonal regeneration. Our lab recently described the identification and

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5

Alqahtani, Saad Mohammed S. "Molecular Determinants for Binding of the FDA-Approved Drugs in Proteins – A Data Mining and Advanced Quantum Chemical Study." University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1493378726116385.

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6

MASSARO, DAMIANO SERGIO. "Drug Reprofile for Friedreich’s Ataxia: Screening of an FDA-Approved Drugs Library searching for small molecules that increase Frataxin." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/203080.

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Freidreich’s Ataxia (FRDA) is a neurodegenerative, autosomal hereditary disease characterized by progressive neurodegeneration, cardiomyopathy and increased incidence of diabetes. The disease is caused by a trinucleotide GAA repeat expansion within the first intron of the gene coding for frataxin protein (FXN). Pathological GAA expansion (from ~70 to >1,000 triplets) results in “sticky” DNA structures and epigenetic changes that severely reduce transcription of the gene. FRDA patients live with 10-30% residual frataxin. The severity of the disease is proportionally related to the number of

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7

Capua, Christopher James. "Comparative Cytotoxicity of an FDA-approved Cancer Drug to Extracts of Atriplex confertifolia on Human Breast and Cervical Cancer Cells." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/1703.

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The severity and number of people affected by cancer is a worldwide problem with millions of people affected annually. The search for treatment and cures of cancer continues to be a global effort. As part of this global effort, many natural products have been tested against cancer cell lines, most from plants located in tropical regions. However, this study reports that extracts of Atriplex confertifolia, a native North American plant, has significant bioactivity against human breast cancer cell lines MCF-7, 435, and 231, and HeLa cells (cervical cancer cells). The bioactivity of A. confertifo

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8

Chen, Po Chang, and 陳柏昌. "The Impact of FDA New Drug Approval on Abnormal Return of Nasdaq Biotech Stock." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/64978819916415095797.

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碩士<br>長庚大學<br>企業管理研究所<br>97<br>We observe two kinds of stocks. One is the components of Nasdaq Biotechnology Index (hereafter, cNBI) and the other is components of Phlx Drug Index (hereafter, cRXS). This study use an event study methodology for calculating abnormal return (hereafter, AR) and cumulative abnormal return (hereafter, CAR) in the condition of FDA new drugs approvals. We use t-test to check whether AR differ from zero and use multiple regression model to examine whether some variables have influences in AR. We have three findings. First, AR of cNBI is significantly higher than zero,

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9

Ting, Hsiu Wen, and 丁秀文. "Announcement Effect of Drug Approvals by FDA." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/47956984302631612365.

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碩士<br>國立政治大學<br>財務管理研究所<br>96<br>In this paper, we use event-study to estimate the stock price changes of Food and Drug Administration (FDA) decisions on new products for pharmaceutical companies. We find that FDA decisions have insignificant effects in all countries on the drug approval date. The insignificant price changes accompanying FDA announcements approval suggest that drug results have leaked to the market. It is quite possible that the results of advisory are open to public and advisory committee are held before FDA approval, advisory committee can be viewed as important news source

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10

Chang, En-Kai, and 張恩愷. "Combinatorial effects of six FDA approved drugs on influenza virus." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/3272nt.

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碩士<br>國立陽明大學<br>微生物及免疫學研究所<br>106<br>英文摘要 Influenza virus belongs to Orthomyxoviridae. Influenza spreads around the world yearly, resulting in about three to five million cases of severe illness and about 250,000 to 500,000 deaths. The only drugs currently available to treat influenza are neuraminidase ( NA ) inhibitors,including oseltamivir ( Tamiflu ), zanamivir and peramivir, and an RNA-dependent RNA polymerase ( RdRp ) inhibitor, favipiravir ( Avigan ). Since influenza virus RdRp lacks proofreading activity, the genome is easy to mutate when replicating. As a result, drug resistance and li

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11

Bapatla, Neha. "An evaluation and comparison of current FDA-approved treatments for obesity." Thesis, 2018. https://hdl.handle.net/2144/30872.

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As society adopts a sedentary lifestyle coupled with increased energy intake, obesity continues to spread pervasively throughout the world. It poses a strong public health threat due to the development of related comorbidities in individuals, such as diabetes, hypertension, dyslipidemia, and obstructive sleep apnea. Prior to the new millennium, treatment of obesity included lifestyle modifications or bariatric surgery. However, this alienated a large subset of the population who were unable to lose weight with behavioral changes alone but not obese enough to qualify for bariatric surgery. Thus

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12

Yung-ChiehChen and 陳雍傑. "The Research on How Biotech Laws and FDA Approvals Affects Abnormal Returns in Biotech Firms." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/52104192880955434543.

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碩士<br>國立成功大學<br>會計學系<br>102<br>This study uses event study to examine the relation between the approvals of FDA and abnormal returns for listed, OTC and emerging biotech companies in Taiwan. Our research finds that there are positive and significant cumulated abnormal returns due to the FDA approval news announcement by collecting news from Taiwan Economic Journal. It shows that whether the drugs are approved or not matters for investors. As for the long period of verification, the middle stages, including the phase 1 testing, phase 2 testing, phase 3 testing and facility inspection, have high

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13

Fan, Ya-Wen, and 范雅雯. "The effect and molecular action of curcumin in FDA-approved clinical drug-treated human bladder cancer cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/63474138092702105330.

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碩士<br>國立臺灣師範大學<br>人類發展與家庭學系<br>102<br>Bladder cancer is the ninth most common cancer worldwide and the fourteenth most diagnosed malignancy in Taiwan (2013). Gemcitabine plus cisplatin (GC) treatment is prefered for nowadays treatment. For patients with impaired renal function, gemcitabine plus carboplatin (GCa) treatment is recommended. Overexpressions of Aurora A kinase and epidermal growth factor (EGF) were observed in bladder cancer cells. Our previously data demonstrate that curcumin significantly inhibited Aurora A gene expression, in part caused failure of various mitotic events and G2/

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14

Wu, Chi-Shiuan, and 吳奇軒. "The role of KRAS gene in combination treatment of Curcumin and FDA-approved Targeted Drugs in human colorectal cancer cells." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/69752446398460271062.

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15

"Lead Identification, Optimization and Characterization of Novel Cancer Treatment Strategies Using Repositioned Drugs." Doctoral diss., 2013. http://hdl.handle.net/2286/R.I.18035.

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abstract: Cancer is the second leading cause of death in the United States and novel methods of treating advanced malignancies are of high importance. Of these deaths, prostate cancer and breast cancer are the second most fatal carcinomas in men and women respectively, while pancreatic cancer is the fourth most fatal in both men and women. Developing new drugs for the treatment of cancer is both a slow and expensive process. It is estimated that it takes an average of 15 years and an expense of $800 million to bring a single new drug to the market. However, it is also estimated that nearly 40%

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16

(8803004), Logan C. Ganzen. "Drug Screening Utilizing the Visual Motor Response of a Zebrafish Model of Retinitis Pigmentosa." Thesis, 2020.

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Retinitis Pigmentosa (RP) is an incurable inherited retinal degeneration affecting approximately 1 in 4,000 individuals globally. The aim of this dissertation was to identify drugs that can help patients suffering from the disease. To accomplish this goal, the zebrafish was utilized as a model for RP to perform <i>in vivo</i> drug screening. The zebrafish RP model expresses a human rhodopsin transgene which contains a premature stop codon at position 344 (<i>Tg</i>(<i>rho:Hsa.RH1_Q344X</i>)). This zebrafish model exhibits significant rod photoreceptor degeneration beginning at 7 days post fert

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17

Wang, Tao. "Iron sulfur cluster assembly in Photosystem I of cyanobacteria the role of SufR (SUF) and FDX (ISC) /." 2004. http://www.etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-463/index.html.

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18

Shee, Somnath. "Manipulating Bacterial and Host Reactive Oxygen Species (ROS)- based mechanisms to potentiate killing of Mycobacterium tuberculosis (Mtb)." Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5680.

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Mycobacterium tuberculosis (Mtb) is evolutionarily equipped to resist exogenous reactive oxygen species but shows vulnerability to an increase in endogenous ROS (eROS). Since eROS is an unavoidable consequence of aerobic metabolism, understanding how eROS levels are controlled is essential yet remains uncharacterized. By combining the Mrx1-roGFP2 redox biosensor with transposon mutagenesis, we identified 368 genes (redoxosome) responsible for maintaining non-toxic levels of eROS in Mtb. Integrating redoxosome with a global network of protein-protein interactions and transcriptional regulators

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