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Journal articles on the topic 'FDG (fluoro-deoxy glucose)'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Videnovic-Ivanov, Jelica, Dragana Sobic-Saranovic, Isidora Grozdic, Violeta Mihailovic-Vucinic, Snezana Filipovic, and Mihailo Stjepanovic. "The application results of 18F - FDG/PET scan in chronic sarcoidosis." Medical review 66, suppl. 1 (2013): 50–53. http://dx.doi.org/10.2298/mpns13s1050v.

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Introduction. The authors evaluated the application of 18 Ffluoro-2-deoxy-D: -glucose positron emission tomography/computed tomography to diagnose the activity in patients with chronic sarcoidosis. Material and Methods. The study sample included 71 patients (48 females and 23 males, their mean age being 47?3 years) with biopsy-proven sarcoidosis of chronic course. Results. All patients underwent 18 F-fluoro-2-deoxy-D: -glucose positron emission tomography/computed tomography, which detected inflammation in 65 patients (91.5%) (maximum standardized uptake value, 8.1 ? 3.9). Angiotensin-converti

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Yu, Amy S., Bruce A. Hirayama, Gerald Timbol, et al. "Functional expression of SGLTs in rat brain." American Journal of Physiology-Cell Physiology 299, no. 6 (2010): C1277—C1284. http://dx.doi.org/10.1152/ajpcell.00296.2010.

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This work provides evidence of previously unrecognized uptake of glucose via sodium-coupled glucose transporters (SGLTs) in specific regions of the brain. The current understanding of functional glucose utilization in brain is largely based on studies using positron emission tomography (PET) with the glucose tracer 2-deoxy-2-[F-18]fluoro-d-glucose (2-FDG). However, 2-FDG is only a good substrate for facilitated-glucose transporters (GLUTs), not for SGLTs. Thus, glucose accumulation measured by 2-FDG omits the role of SGLTs. We designed and synthesized two high-affinity tracers: one, α-methyl-4

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Medak, Adrianna, Julia Wojtowicz, Katarzyna Pietrasz, et al. "Użyteczność badania 18F-FDG PET/CT w diagnostyce guzów pierwotnych i przerzutów nowotworowych do mózgu." Letters in Oncology Science 17, no. 3 (2020): 1–7. http://dx.doi.org/10.21641/los.2020.17.3.183.

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Celem niniejszej pracy jest wykazanie, że mimo nieswoistego charakteru radiofarmaceutyku 2-deoxy-2-[18F]fluoro-D-glukozy (z ang. 2-deoxy-2-[18F]fluoro-D-glucose, 18F-FDG), badanie pozytonowej tomografii emisyjnej/tomografii komputerowej (z ang. positron emission tomography/computed tomography, PET/CT) z użyciem 18F-FDG pozwala wykryć guzy pierwotne i przerzuty nowotworowe do mózgu, co może znacząco wpłynąć na protokół terapeutyczny i jakość życia chorego onkologicznie.

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Wienhard, K., G. Pawlik, B. Nebeling, et al. "Estimation of Local Cerebral Glucose Utilization by Positron Emission Tomography: Comparison of [18F]2-Fluoro-2-Deoxy-D-Glucose and [18F]2-Fluoro-2-Deoxy-D-Mannose in Patients with Focal Brain Lesions." Journal of Cerebral Blood Flow & Metabolism 11, no. 3 (1991): 485–91. http://dx.doi.org/10.1038/jcbfm.1991.92.

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A comparative PET study of [18F]2-fluoro-2-deoxy-D-glucose (FDG) and [18F]2-fluoro-2-deoxy-D-mannose (FDM) uptake was performed in 13 patients with focal brain lesions. Differences between FDG and FDM with respect to model rate constants, lumped constant, and estimated metabolic rate for glucose were determined on a regional basis. Across whole brain, the transport rate constant K*1 was almost unchanged, whereas k*2, describing the transport back from tissue to plasma, was 6% higher, and the phosphorylation rate constant k*3 was 9% lower for FDM compared to FDG. This implies a 20% lower lumped

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Penna, Patricia Sola, Sergio Augusto Lopes De Souza, Paulo Gustavo Limeira Nobre De Lacerda, et al. "Evidencing leprosy neuronal inflammation by 18-Fluoro-deoxy-glucose." PLOS Neglected Tropical Diseases 17, no. 6 (2023): e0011383. http://dx.doi.org/10.1371/journal.pntd.0011383.

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Background Leprosy is caused by multiple interactions between Mycobacterium leprae (M. leprae) and the host’s peripheral nerve cells. M. leprae primarily invades Schwann cells, causing nerve damage and consequent development of disabilities. Despite its long history, the pathophysiological mechanisms of nerve damage in the lepromatous pole of leprosy remain poorly understood. This study used the findings of 18F-FDG PET/CT on the peripheral nerves of eight lepromatous patients to evaluate the degree of glucose uptake by peripheral nerves and compared them with clinical, electrophysiological, an

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Nguyen, V. T., K. A. Mossberg, T. J. Tewson, et al. "Temporal analysis of myocardial glucose metabolism by 2-[18F]fluoro-2-deoxy-D-glucose." American Journal of Physiology-Heart and Circulatory Physiology 259, no. 4 (1990): H1022—H1031. http://dx.doi.org/10.1152/ajpheart.1990.259.4.h1022.

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To assess kinetic changes of myocardial glucose metabolism after physiological interventions, we perfused isolated working rat hearts with glucose and 2-[18F]fluoro-2-deoxy-D-glucose (2-FDG). Tissue uptake of 2-FDG and the input function were measured on-line by external detection. The fractional rate of 2-FDG phosphorylation was determined by graphical analysis of time-activity curves. The steady-state uptake of 2-FDG was linear with time, and the tracer was retained predominantly in its phosphorylated form. Tissue accumulation of 2-FDG decreased with a reduction in work load and with the add

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Cauchon, Nicole, Haroutioun M. Hasséssian, Eric Turcotte, Roger Lecomte, and Johan E. van Lier. "Deciphering PDT-induced inflammatory responses using real-time FDG-PET in a mouse tumour model." Photochem. Photobiol. Sci. 13, no. 10 (2014): 1434–43. http://dx.doi.org/10.1039/c4pp00140k.

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Dynamic positron emission tomography (PET), combined with constant infusion of 2-deoxy-2-[<sup>18</sup>F]fluoro-d-glucose (FDG), enables real-time monitoring of transient metabolic changesin vivo, which can serve to understand the underlying physiology.

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Huellner, M. W., M. Cousin, T. Linder, et al. "Melanoma of the middle ear: initial presentation, Fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography imaging and follow up." Journal of Laryngology & Otology 125, no. 5 (2011): 536–39. http://dx.doi.org/10.1017/s0022215110002872.

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AbstractBackground:We present a rare case of primary mucosal melanoma of the middle ear imaged with 18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT).Method:Clinical, radiological, intra-operative and histological findings are discussed.Results:An 88-year-old woman presented with intermittent otorrhoea of the left ear for several months. Otoscopy revealed a livid protrusion of the tympanic membrane. Melanoma was not suspected initially, but was established on transmembranous biopsy. Pre-operative 18F-fluoro-2-deoxy-d-glucose positron emission tomography

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Shin, Young Shik, Jungwoo Kim, Dazy Johnson, et al. "Quantitative assessments of glycolysis from single cells." TECHNOLOGY 03, no. 04 (2015): 172–78. http://dx.doi.org/10.1142/s2339547815200058.

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The most common positron emission tomography (PET) radio-labeled probe for molecular diagnostics in patient care and research is the glucose analog, 2-deoxy-2-[F-18]fluoro-D-glucose (18F-FDG). We report on an integrated microfluidics-chip/beta particle imaging system for in vitro 18F-FDG radioassays of glycolysis with single cell resolution. We investigated the kinetic responses of single glioblastoma cancer cells to targeted inhibitors of receptor tyrosine kinase signaling. Further, we find a weak positive correlation between cell size and rate of glycolysis.

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Nanni, Cristina. "PET-FDG: Impetus." Cancers 12, no. 4 (2020): 1030. http://dx.doi.org/10.3390/cancers12041030.

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The International Myeloma Working Group (IMWG)recommends FDG PET/CT (Fluoro-Deoxy-glucose Positron Emission Tomography/Computed Tomography) as the gold standard imaging modality for initial evaluation and response to therapy assessment in multiple myeloma. In fact, FDG PET/CT, provides multiple useful indexes to risk-stratify patients and has significant prognostic value. However, multiple myeloma remains a complex disease to interpret on imaging. The Italian myeloma criteria for PET use (IMPeTUs) were proposed to standardize FDG PET/CT reading in multiple myeloma. In this communication an ove

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McFalls, Edward O., Douglas Baldwin, David Marx, Peggy Fashingbauer, and Herbert B. Ward. "Effect of regional hyperemia on myocardial uptake of 2-deoxy-2-[18F]fluoro-d-glucose." American Journal of Physiology-Endocrinology and Metabolism 278, no. 1 (2000): E96—E102. http://dx.doi.org/10.1152/ajpendo.2000.278.1.e96.

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2-Deoxy-2-[18F]fluoro-d-glucose (FDG) may be used to predict glucose kinetics when the factor relating differences in transport and phosphorylation between compounds remains constant (“lumped constant”). It is not clear whether hyperemia alters that factor. In anesthetized swine, myocardial FDG uptake was estimated by positron emission tomography, during an intracoronary infusion of either adenosine, ATP, or bradykinin (40 μg ⋅ kg−1 ⋅ min−1, 40 μg ⋅ kg−1 ⋅ min−1, and 2 nmol ⋅ kg− 1 ⋅ min− 1, respectively; n = 6 for all groups). In controls during normal perfusion ( n = 6), FDG uptake was 0.78

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Marshall, Robert C., Patricia Powers-Risius, Ronald H. Huesman, et al. "Estimating glucose metabolism using glucose analogs and two tracer kinetic models in isolated rabbit heart." American Journal of Physiology-Heart and Circulatory Physiology 275, no. 2 (1998): H668—H679. http://dx.doi.org/10.1152/ajpheart.1998.275.2.h668.

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The purpose of this investigation was to 1) evaluate the relative accuracy of the Sokoloff and Patlak tracer kinetic models in estimating glucose metabolic rate (GMR) in the presence and absence of insulin; 2) evaluate the effect of nutritional state on the lumped constant (LC); and 3) compare the kinetics of 2-fluoro-2-deoxy-d-[14C]glucose (FDG) and 2-deoxy-d-[3H]glucose (DG) membrane transport and phosphorylation. The experimental preparation was the isolated, red blood cell-albumin-perfused rabbit heart. Our results showed that both tracer kinetic models provided GMR estimates that correlat

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Bjurberg, Maria, Elisabeth Kjellén, Tomas Ohlsson, Pär-Ola Bendahl, and Eva Brun. "Prediction of Patient Outcome With 2-Deoxy-2-[18F]fluoro-D-Glucose-Positron Emission Tomography Early During Radiotherapy for Locally Advanced Cervical Cancer." International Journal of Gynecologic Cancer 19, no. 9 (2009): 1600–1605. http://dx.doi.org/10.1111/igc.0b013e3181c00359.

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Introduction:It is difficult to assess the individual response of locally advanced cervical cancer to chemoradiation therapy during the course of treatment. We have investigated the predictive value of positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) early during treatment in relation to progression-free survival.Methods:This prospective single-center clinical trial included women with locally advanced cervical cancer from 2004 to 2008. 2-Deoxy-2-[18F]fluoro-D-glucose-PET/computed tomography was performed at baseline, during the third week of treatment and, finally

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Drane, W. E., M. W. Nicole, S. T. Mastin, and J. H. Kuperus. "SPECT with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG)." Radiology 197, no. 2 (1995): 341–42. http://dx.doi.org/10.1148/radiology.197.2.7480674.

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Li, Wenlin, Cathy Zhang, Nanni Huser, Chad Ray, Scott Fountain, and Erick Kindt. "A quantitative LC–MS/MS approach for monitoring 2′-fluoro-2′-deoxy-D-glucose uptake in tumor tissue." Bioanalysis 13, no. 6 (2021): 481–91. http://dx.doi.org/10.4155/bio-2020-0326.

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Purpose: Develop a quantitative LC–MS/MS method for FDG, FDG-monophosphate, glucose and glucose-monophosphate in mouse tumor models to assist in validating the use of [18F]FDG-positron emission tomography (PET) imaging for anticancer therapies in a clinical setting. Methodology/results: Analytes were isolated from tumors by protein precipitation and detected on a Sciex API-5500 mass spectrometer. Improved assay robustness and selectivity were achieved through chromatographic separation of FDG-monophosphate from glucose-monophosphate, selection of a unique ion transition and incorporation of st

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Pollok, Karen E., Michael Lahn, Nathan Enas, et al. "In Vivo Measurements of Tumor Metabolism and Growth after Administration of Enzastaurin Using Small Animal FDG Positron Emission Tomography." Journal of Oncology 2009 (2009): 1–8. http://dx.doi.org/10.1155/2009/596560.

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Background. The use of 2-[]fluoro-2-deoxy-D-glucose ([]FDG) may help to establish the antitumor activity of enzastaurin, a novel protein kinase C-beta II (PKC-II) inhibitor, in mouse xenografts.Methods. The hematologic cell line RAJI and the solid tumor cell line U87MG were each implanted in NOD/SCID mice. Standard tumor growth measurements and []FDG PET imaging were performed weekly for up to three weeks after tumor implantation and growth.Results. Concomitant with caliper measurements, []FDG PET imaging was performed to monitor glucose metabolism. Heterogeneity of glucose uptake in various a

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Joshi, Prathamesh, Vikram Lele, Rozil Gandhi, and Anil Parab. "Honda Sign On 18-FDG PET/CT in a Case of Lymphoma Leading to Incidental Detection of Sacral Insufficiency Fracture." Journal of Clinical Imaging Science 2 (May 23, 2012): 29. http://dx.doi.org/10.4103/2156-7514.96544.

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Sacral insufficiency fracture (SIF) is an important and treatable cause of low back pain in at-risk groups and the elderly. We report rare demonstration of ‘Honda sign’ in fluoro-deoxy-glucose positron emission tomography-computed tomography (FDG PET-CT) in a case of lymphoma, which led to incidental diagnosis of SIF. Honda sign, which is classically described in bone scans in cases of SIF, was found in FDG PET-CT in our case. This suggests SIF should be suspected when similar FDG uptake pattern is encountered and may help in early detection and management of SIF.

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Cho, YK, and KC Lee. "Standardised uptake values of 2-deoxy-2-[¹⁸F]fluoro-d-glucose using PET/CT in normal cats." Veterinární Medicína 58, No. 2 (2013): 96–104. http://dx.doi.org/10.17221/6701-vetmed.

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In this study we assessed the normal physiological and dynamic thoracoabdominal distribution of <sup>18</sup>F fluorodeoxyglucose (<sup>18</sup>F-FDG) uptake and the standardized uptake values (SUVs) of the major parenchymal organs in five normal young adult domestic short haired cats. Dynamic PET data were acquired with a transaxial field-of-view (FOV) PET/CT scanner, Regions of interests (ROIs) were manually drawn over the left ventricular free wall, left ventricular blood pool, liver, spleen, and left and right renal cortices. The SUVs of these organs were calculated

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Huska, Brenda, Sarah Niccoli, Christopher P. Phenix та Simon J. Lees. "Leucine Potentiates Glucose-mediated 18F-FDG Uptake in Brown Adipose Tissue via β-Adrenergic Activation". Biomedicines 8, № 6 (2020): 159. http://dx.doi.org/10.3390/biomedicines8060159.

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Significant depots of brown adipose tissue (BAT) have been identified in many adult humans through positron emission tomography (PET), with the amount of BAT being inversely correlated with obesity. As dietary activation of BAT has implications for whole body glucose metabolism, leucine was used in the present study to determine its ability to promote BAT activation resulting in increased glucose uptake. In order to assess this, 2-deoxy-2-(fluorine-18)fluoro-d-glucose (18F-FDG) uptake was measured in C57BL/6 mice using microPET after treatment with leucine, glucose, or both in interscapular BA

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Adamcová, Vanda, Klára Kuglerová, Katarína Ondreičková, et al. "Visualization and quantification of 2-deoxy-2-fluoro[18F]-D-glucose in plant tissues by a commercial PET system." Nova Biotechnologica et chimica 19, no. 1 (2020): 98–108. http://dx.doi.org/10.36547/nbc.v19i1.582.

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Some works showed that commercial PET systems and 2-deoxy-2-fluoro[18F]-D-glucose (2-[18F]FDG) can be used in plant studies to analyze the transport and allocation of photoassimilates. The aim of this work was to evaluate the effect of characteristics of plant tissues, applied solution and the phenomenon of “escaping positrons” on the visualisation and quantification of the uptake and distribution

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Sasaki, Hiroshi, Iwao Kanno, Matsutaro Murakami, Fumio Shishido, and Kazuo Uemura. "Tomographic Mapping of Kinetic Rate Constants in the Fluorodeoxyglucose Model Using Dynamic Positron Emission Tomography." Journal of Cerebral Blood Flow & Metabolism 6, no. 4 (1986): 447–54. http://dx.doi.org/10.1038/jcbfm.1986.78.

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A quick computing algorithm to calculate the rate constants ( k*1, k*2, k*3) in the [18F]2-fluoro-2-deoxy-d-glucose (FDG) model was developed. The algorithm solved for the rate constants pixel by pixel using a conventional least-squares method and two tables consisting of a set of various rate constants, to shorten the computing time. Five planes of rate constant images were obtained. A combined study using the dynamic FDG method and the 15O-labeled gas continuous inhalation method was performed on seven healthy male volunteers aged 26–35 years. Results indicated an apparent discrepancy betwee

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Hasselbalch, Steen G., Peter L. Madsen, Gitte M. Knudsen, Søren Holm, and Olaf B. Paulson. "Calculation of the FDG Lumped Constant by Simultaneous Measurements of Global Glucose and FDG Metabolism in Humans." Journal of Cerebral Blood Flow & Metabolism 18, no. 2 (1998): 154–60. http://dx.doi.org/10.1097/00004647-199802000-00005.

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The lumped constant defined as the conversion factor between the net uptake of fluoro-2-deoxy-D-glucose (FDG) and glucose was calculated from global CMRglc and from positron emission tomography (PET) using FDG as tracer (CMRFDG). Fifteen healthy, normal volunteers (mean age 24 ± 4 years) were studied. Global CBF and CMRglc were measured with the Kety-Schmidt technique using 133Xe as tracer, and values were corrected for errors from incomplete diffusion equilibrium for inert gas tracer between brain tissue and cerebral venous blood. Measurements of CMRFDG were obtained with PET using the dynami

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Schmidt, K., G. Lucignani, R. M. Moresco, et al. "Errors Introduced by Tissue Heterogeneity in Estimation of Local Cerebral Glucose Utilization with Current Kinetic Models of the [18F]Fluorodeoxyglucose Method." Journal of Cerebral Blood Flow & Metabolism 12, no. 5 (1992): 823–34. http://dx.doi.org/10.1038/jcbfm.1992.114.

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The effects of tissue heterogeneity on the estimation of regional cerebral glucose utilization (rCMRglc) in normal humans with [18F]2-fluoro-2-deoxy-d-glucose ([18F]FDG) and positron emission tomography (PET) were compared with respect to the various kinetic models of the [18F]FDG method. The kinetic models were conventional homogeneous tissue models of the [18F]FDG method, with (4K Model) and without (3K Model) a rate constant to account for an apparent loss of [18F]2-fluoro-2-deoxy-d-glucose-6-phosphate ([18F]FDG-6-P), and a tissue heterogeneity model (TH Model). When either of the kinetic m

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El Kiki, Nada Adel Awad, Fatma Salah El Deen Mohamed, Amal Amin Abu El Maati, and Nermeen Nasry Keriakos. "Relation between tumor SUVmax, TLR and TSR and breast carcinoma molecular subtypes in PET CT." International journal of health sciences 6, S1 (2022): 1763–72. http://dx.doi.org/10.53730/ijhs.v6ns1.4936.

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Breast cancer is known to be one of the most cancer affecting women around the globe and the second most common cancer in general. In third worlds countries, breast cancer is the most cause of cancer death. Early diagnosis and accurate follow-up of these patients affect the management. There are multiple prognostic factors most important one is the immunohistochemical molecular markers in the specimens including human epidermal growth factor, progesterone, and estrogen receptors (HER 2, PR, ER). In breast cancer, the HER2 positive molecular subtype is associated with bad prognosis and aggressi

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Pietrzak, Agata, Andrzej Marszałek, Tomasz Piotrowski, et al. "Primary and Metastatic Brain Tumours Assessed with the Brain and Torso [18F]FDG PET/CT Study Protocol—10 Years of Single-Institutional Experiences." Pharmaceuticals 14, no. 8 (2021): 722. http://dx.doi.org/10.3390/ph14080722.

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According to the international societies’ recommendations, the 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) technique should not be used as the method of choice in brain tumour diagnosis. Therefore, the brain region can be omitted during standard [18F]FDG PET/CT scanning. We performed comprehensive literature research and analysed results from 14,222 brain and torso [18F]FDG PET/CT studies collected in 2010–2020. We found 131 clinically silent primary and metastatic brain tumours and 24 benign lesions. We concluded that the brain and torso

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Sharma, R. I., A. E. Welch, L. Schweiger, S. Craib, and T. A. D. Smith. "[]Fluoro-2-Deoxy-D-Glucose Incorporation by MCF-7 Breast Tumour Cells In Vitro Is Modulated by Treatment with Tamoxifen, Doxorubicin, and Docetaxel: Relationship to Chemotherapy-Induced Changes in ATP Content, Hexokinase Activity, and Glucose Transport." International Journal of Molecular Imaging 2011 (October 26, 2011): 1–8. http://dx.doi.org/10.1155/2011/874585.

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Breast tumours responding to chemotherapy exhibit decreased []fluoro-2-deoxy-D-glucose ([]FDG) incorporation. Underlying mechanisms of these changes is poorly understood. Here, in MCF-7 cells, responding to chemotherapy drugs commonly utilised in the treatment of breast cancer, []FDG incorporation and several pivotal factors associated with []FDG incorporation investigated. Methods. IC50 and subclinical doxorubicin, docetaxel, and tamoxifen doses determined using MTT assay. []FDG incorporation by cells treated with IC50 drug doses for 48 hours and 72 hours were determined and FDG dephosphoryla

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Gilardi, Laura, Lighea Simona Airò Farulla, Giuseppe Curigliano, Giovanni Corso, Maria Cristina Leonardi, and Francesco Ceci. "FDG and Non-FDG Radiopharmaceuticals for PET Imaging in Invasive Lobular Breast Carcinoma." Biomedicines 11, no. 5 (2023): 1350. http://dx.doi.org/10.3390/biomedicines11051350.

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Invasive lobular cancer (ILC) is the second most frequent histological type of breast cancer (BC) and includes a heterogeneous spectrum of diseases with unique characteristics, especially the infiltrative growth pattern and metastatic spread. [18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) is extensively used in oncology and BC patient evaluation. Its role in ILCs is considered suboptimal due to its low FDG avidity. Therefore, ILCs could benefit from molecular imaging with non-FDG tracers that target other specific pathways, contributing to precision

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Garbarino, Sara, Giacomo Caviglia, Massimo Brignone, Michela Massollo, Gianmario Sambuceti, and Michele Piana. "Estimate of FDG Excretion by means of Compartmental Analysis and Ant Colony Optimization of Nuclear Medicine Data." Computational and Mathematical Methods in Medicine 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/793142.

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[18F]fluoro-2-deoxy-D-glucose (FDG) is one of the most utilized tracers for positron emission tomography (PET) applications in oncology. FDG-PET relies on higher glycolytic activity in tumors compared to normal structures as the basis of image contrast. As a glucose analog, FDG is transported into malignant cells which typically exhibit an increased radioactivity. However, different from glucose, FDG is not reabsorbed by the renal system and is excreted to the bladder. The present paper describes a novel computational method for the quantitative assessment of this excretion process. The method

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Simoncic, Urban, and Robert Jeraj. "Cumulative Input Function Method for Linear Compartmental Models and Spectral Analysis in PET." Journal of Cerebral Blood Flow & Metabolism 31, no. 2 (2010): 750–56. http://dx.doi.org/10.1038/jcbfm.2010.159.

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Compartmental modeling and spectral analysis are often used for tracer kinetic modeling in positron emission tomography (PET). The concentrations in kinetic equations are usually considered to be instantaneous, whereas PET data are inherently integrated over time, which leads to uncertainties in the results. A new formalism for kinetic analysis that uses cumulative tracer concentrations and avoids approximating the image-derived input function and PET measurements with midframe instantanous values was developed. We assessed the improvements of the new formalism over the midframe approximation

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Pijl, Jordy P., Thomas C. Kwee, Riemer H. J. A. Slart, and Andor W. J. M. Glaudemans. "PET/CT Imaging for Personalized Management of Infectious Diseases." Journal of Personalized Medicine 11, no. 2 (2021): 133. http://dx.doi.org/10.3390/jpm11020133.

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Positron emission tomography combined with computed tomography (PET/CT) is a nuclear imaging technique which is increasingly being used in infectious diseases. Because infection foci often consume more glucose than surrounding tissue, most infections can be diagnosed with PET/CT using 2-deoxy-2-[18F]fluoro-D-glucose (FDG), an analogue of glucose labeled with Fluorine-18. In this review, we discuss common infectious diseases in which FDG-PET/CT is currently applied including bloodstream infection of unknown origin, infective endocarditis, vascular graft infection, spondylodiscitis, and cyst inf

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Tsai, Min-Kuei, Hueisch-Jy Ding, Hsueh-Chou Lai, et al. "Detection of Gastroesophageal Reflux Esophagitis Using 2-fluoro-2-deoxy-d-glucose Positron Emission Tomography." Scientific World Journal 2012 (2012): 1–5. http://dx.doi.org/10.1100/2012/702803.

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Background. Gastroesophageal reflux disease (GERD) is a common disease and a major upper gastrointestinal problem. The purpose of the present study is to evaluate the use of noninvasive 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) to detect gastroesophageal reflux esophagitis.Materials and Methods. This is a retrospective study reviewing 408 healthy check-up subjects (169 females and 239 men), who underwent both FDG-PET and upper gastrointestinal endoscopy during September 2008 to December 2009. Quantitative analysis of FDG uptake in the distal part of the esophagus was pe

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Herholz, Karl, Uwe Pietrzyk, Jürgen Voges, et al. "Correlation of glucose consumption and tumor cell density in astrocytomas." Journal of Neurosurgery 79, no. 6 (1993): 853–58. http://dx.doi.org/10.3171/jns.1993.79.6.0853.

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✓ To determine histological correlates of the variability of glucose consumption in astrocytomas, the authors performed positron emission tomography (PET) with 18F-2-fluoro-2-deoxy-D-glucose (FDG) and matched the PET scans three-dimensionally with computerized tomography scans obtained in a stereotactic frame before biopsy. Ten patients with astrocytomas of World Health Organization Grade 2 or 3 were studied; patients with glioblastomas, oligodendrogliomas, or oligoastrocytomas were excluded from the study to avoid any confounding effects of different cell types and necroses. In samples of pur

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Santos-Oliveira, Ralph. "Influence of radiation on endotoxin test using the PTS TM for 18-FDG radiopharmaceutical." Brazilian Journal of Pharmaceutical Sciences 46, no. 3 (2010): 551–54. http://dx.doi.org/10.1590/s1984-82502010000300019.

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F-18 FDG (2-[18-F] fluoro-2-deoxy-D-glucose) is the most frequently used radiopharmaceutical for PET and PET CT imaging exams. The FDA recently approved the use of the PTS TM (Portable Test System) as an alternative to the standard test proposed by the United States Pharmacopeia using the LAL (Limulus Amebocyte Lysates), that takes longer to perform (about 1h) than the PTS TM (15 min). Recent studies have demonstrated that radiation could interfere with the PTS TM test. In order to study the effects of radiation on the PTS TM test and/or equipment, 27 batches of F-18 FDG produced in the Nuclea

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Feng, Han, Xiaobo Wang, Jian Chen, et al. "Nuclear Imaging of Glucose Metabolism: Beyond 18F-FDG." Contrast Media & Molecular Imaging 2019 (March 26, 2019): 1–12. http://dx.doi.org/10.1155/2019/7954854.

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Glucose homeostasis plays a key role in numerous fundamental aspects of life, and its dysregulation is associated with many important diseases such as cancer. The atypical glucose metabolic phenomenon, known as the Warburg effect, has been recognized as a hallmark of cancer and serves as a promising target for tumor specific imaging. At present, 2-deoxy-2-[18F]fluoro-glucose (18F-FDG)-based positron emission tomography/computed tomography (PET/CT) represented the state-of-the-art radionuclide imaging technique for this purpose. The powerful impact of 18F-FDG has prompted intensive research eff

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Honka, Miikka-Juhani, Eleni Rebelos, Simona Malaspina, and Pirjo Nuutila. "Hepatic Positron Emission Tomography: Applications in Metabolism, Haemodynamics and Cancer." Metabolites 12, no. 4 (2022): 321. http://dx.doi.org/10.3390/metabo12040321.

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Evaluating in vivo the metabolic rates of the human liver has been a challenge due to its unique perfusion system. Positron emission tomography (PET) represents the current gold standard for assessing non-invasively tissue metabolic rates in vivo. Here, we review the existing literature on the assessment of hepatic metabolism, haemodynamics and cancer with PET. The tracer mainly used in metabolic studies has been [18F]2-fluoro-2-deoxy-D-glucose (18F-FDG). Its application not only enables the evaluation of hepatic glucose uptake in a variety of metabolic conditions and interventions, but based

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Gheysens, Olivier, François Jamar, Andor W. J. M. Glaudemans, Halil Yildiz, and Kornelis S. M. van der Geest. "Semi-Quantitative and Quantitative [18F]FDG-PET/CT Indices for Diagnosing Large Vessel Vasculitis: A Critical Review." Diagnostics 11, no. 12 (2021): 2355. http://dx.doi.org/10.3390/diagnostics11122355.

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To confirm the diagnosis of large vessel vasculitis (LVV) with high accuracy, one of the recommended imaging techniques is [18F]Fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography ([18F]FDG-PET/CT). Visual assessment of [18F]FDG uptake in the arterial wall compared to liver uptake is the mainstay for diagnosing LVV in routine clinical practice. To date, there is no consensus on the preferred semi-quantitative or quantitative parameter for diagnosing LVV. The aim of this review is to critically update the knowledge on the available evidence of semi-quantitative and qu

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Zhang-Yin, Jules, Antoine Girard, Etienne Marchal, et al. "PET Imaging in Bladder Cancer: An Update and Future Direction." Pharmaceuticals 16, no. 4 (2023): 606. http://dx.doi.org/10.3390/ph16040606.

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Molecular imaging with positron emission tomography is a powerful tool in bladder cancer management. In this review, we aim to address the current place of the PET imaging in bladder cancer care and offer perspectives on potential future radiopharmaceutical and technological advancements. A special focus is given to the following: the role of [18F] 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography in the clinical management of bladder cancer patients, especially for staging and follow-up; treatment guided by [18F]FDG PET/CT; the role of [18F]FDG PET/MRI, the other PET radiopharmaceu

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Chin, Bennett B., Pavni Patel, Christian Cohade, Marge Ewertz, Richard Wahl, and Paul Ladenson. "Recombinant Human Thyrotropin Stimulation of Fluoro-d-Glucose Positron Emission Tomography Uptake in Well-Differentiated Thyroid Carcinoma." Journal of Clinical Endocrinology & Metabolism 89, no. 1 (2004): 91–95. http://dx.doi.org/10.1210/jc.2003-031027.

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TSH stimulates thyrocyte metabolism, glucose transport, and glycolysis. 2-Deoxy-2-[18F]fluoro-d-glucose (FDG) is a glucose analog used in positron emission tomography (PET) to detect occult well-differentiated thyroid carcinoma. The objective of this study was to examine the effects of recombinant human TSH (rTSH) on FDG PET uptake in patients with residual or recurrent disease. Seven patients with well-differentiated thyroid carcinoma, negative 131-I scintigraphy, and biochemical evidence of residual disease were randomized and prospectively studied with FDG PET both on thyroid hormone suppre

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Kaira, Kyoichi, Masahiro Endo, Masato Abe, et al. "Biologic Correlation of 2-[18F]-Fluoro-2-Deoxy-D-Glucose Uptake on Positron Emission Tomography in Thymic Epithelial Tumors." Journal of Clinical Oncology 28, no. 23 (2010): 3746–53. http://dx.doi.org/10.1200/jco.2009.27.4662.

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Purpose The usefulness of 2-[18F]-fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography (PET) can help predict the grade of malignancy and staging in thymic epithelial tumors. However, no satisfactory biologic explanation exists for this phenomenon. The aim of this study was to investigate the underlying biologic mechanisms of [18F]FDG uptake. Patients and Methods Forty-nine patients with thymic epithelial tumors who underwent [18F]FDG PET were included in this study. Tumor sections were stained by immunohistochemistry for glucose transporter 1 (GLUT1), glucose transporter 3 (GLUT3)

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Ergül, Nurhan, and Tevfik Fikret Çermik. "FDG-PET or PET/CT in Fever of Unknown Origin: The Diagnostic Role of Underlying Primary Disease." International Journal of Molecular Imaging 2011 (March 3, 2011): 1–8. http://dx.doi.org/10.1155/2011/318051.

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Fever of unknown origin (FUO) is generally defined as a fever greater than 38.3°C on several occasions during a period longer than 3 weeks for which the etiology behind cannot be diagnosed at the end of at least 1 week hospital stay. Conventional diagnostic methods are still not adequate to reveal underlying reason in approximately 50% of patients with FUO. In patients with certain diagnosis, three major categories are infections, malignancies, and noninfectious inflammatory diseases. Fluoro-18-fluoro-2-deoxy-D:-glucose (FDG) is a structural analog of 2-deoxyglucose and accumulates in malignan

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Ferrarazzo, Giulia, Silvia Chiola, Selene Capitanio, et al. "Positron Emission Tomography (PET) Imaging of Multiple Myeloma in a Post-Treatment Setting." Diagnostics 11, no. 2 (2021): 230. http://dx.doi.org/10.3390/diagnostics11020230.

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2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (FDG PET/CT) has an established clinical value in the diagnosis and initial staging of multiple myeloma (MM). In the last ten years, a vast body of literature has shown that this tool can also be of high relevance for monitoring therapy responses, making it the recommended imaging approach in this field. Starting from the strengths and weaknesses of radiological imaging in MM, the present review aims to analyze FDG PET/CT’s current clinical value focusing on therapy response assessment and objective interpre

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Wenlan, Zhou, Wu Hubing, Han Yanjiang, Wang Shaobo, Dong Ye, and Wang Quanshi. "Preliminary study on the evaluation of Langerhans cell histiocytosis using F-18-fluoro-deoxy-glucose PET/CT." Chinese Medical Journal 127, no. 13 (2014): 2458–62. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20140201.

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Background Limited number of studies have been reported regarding the utilization of F-18-fluoro-deoxy-glucose (F-18-FDG) positron emission tomography/computed tomography (F-18-FDG PET/CT) in Langerhans cell histiocytosis (LCH). The aim of this study was to assess the role of F-18-FDG PET/CT in the diagnosis and treatment of LCH. Methods Eight newly diagnosed and seven recurrent patients with LCH received F-18-FDG PET/CT scans. The diagnosis of LCH was established by pathology, multi-modality imaging, and clinical follow-up. Results F-18-FDG PET/CT was positive in 14 patients with 13 true posi

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Hawkins, Randall A., Michael E. Phelps, and Sung-Cheng Huang. "Effects of Temporal Sampling, Glucose Metabolic Rates, and Disruptions of the Blood—Brain Barrier on the FDG Model with and without a Vascular Compartment: Studies in Human Brain Tumors with PET." Journal of Cerebral Blood Flow & Metabolism 6, no. 2 (1986): 170–83. http://dx.doi.org/10.1038/jcbfm.1986.30.

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The addition of a cerebral blood volume (CBV) compartment in the [18F]2-fluoro-2-deoxy-d-glucose (FDG) model produces estimates of local CBV simultaneously with glucose metabolic rates when kinetic FDG studies are performed. We investigated the influence of this term upon CMRglc values in a series of brain tumor patients and found that significant overestimations of CMRglc are possible if the effect of CBV upon the model is ignored. The magnitude of this potential over-estimation is directly related to the absolute value of CBV locally and inversely related to the CMRglc value. The kinetic est

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Moadel, Renee M., Richard H. Weldon, Ellen B. Katz, et al. "Positherapy: Targeted Nuclear Therapy of Breast Cancer with 18F-2-Deoxy-2-Fluoro-d-Glucose." Cancer Research 65, no. 3 (2005): 698–702. http://dx.doi.org/10.1158/0008-5472.698.65.3.

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Abstract Breast cancer remains a major cause of cancer death in women in the United States. Novel therapies are needed for patients when standard treatments are ineffective. We have recently shown on a cellular level the therapeutic potential of positrons in malignancy. Here, we report for the first time positron therapy with 18F-2-deoxy-2-fluoro-d-glucose (18F-FDG) in a breast cancer animal model to affect tumor growth rate and survival (positherapy). We used xenografted mammary tumors in nude mice using Notch mammary cancer cells which also express ras oncogene. Notch xenografted tumors acti

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Tambat, Ramesh Mahadev, Venuprasad Narasimhaiah, Marshall David Collin, et al. "Surgical intervention as a curative major for secondary hypertension." International Surgery Journal 8, no. 8 (2021): 2480. http://dx.doi.org/10.18203/2349-2902.isj20213151.

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Retroperitoneal functional paraganglioma is a rare type of neuroendocrine neoplasm which secrete excess catecholamines including epinephrine, norepinephrine, dopamine and their metabolites metanephrine, normetanephrine, 3-methoxytyramine respectively. Early diagnosis of functional paraganglioma is important because its removal is often curative. The extent of disease is evaluate using 2(18F)-fluoro-2 deoxy-D-glucose positron emission tomography (FDG-PET), where increased uptake of 18-FDG observed the mass. It is one of the rare curable causes of secondary hypertension. Here, we have presented

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Diaz, Facundo N., Marina Ulla, Jose M. Lastiri, Fernando G. Wright, and Demetrio Cavadas. "Pneumo-PET-CT: Initial Results of This Novel Technique on the Evaluation of Esophageal and Gastric Tumors with Anatomic-Surgical Correlation." Gastroenterology Research and Practice 2019 (February 5, 2019): 1–8. http://dx.doi.org/10.1155/2019/4123851.

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We present the initial results of a novel hybrid scanning-based technique that combines pneumo-computed tomography (PNCT) with positron emission tomography (PET) using 2-(fluorine-18) fluoro-2-deoxy-D-glucose (FDG). We denominate it pneumo-PET-CT. The focus of our discussion will be on the description of the pneumo-PET-CT technique and the interpretation criteria with emphasis on its benefits and applications in the presurgical and postneoadjuvant therapy evaluation of esophageal, esophagogastric junction (EGJ), and gastric tumors.

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Donegani, Maria Isabella, Giulia Ferrarazzo, Stefano Marra, et al. "Positron Emission Tomography-Based Response to Target and Immunotherapies in Oncology." Medicina 56, no. 8 (2020): 373. http://dx.doi.org/10.3390/medicina56080373.

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2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) is a promising tool to support the evaluation of response to either target therapies or immunotherapy with immune checkpoint inhibitors both in clinical trials and, in selected patients, at the single patient’s level. The present review aims to discuss available evidence related to the use of [18F]FDG PET (Positron Emission Tomography) to evaluate the response to target therapies and immune checkpoint inhibitors. Criteria proposed for the standardization of the definition of the PET-based response and complementary value with respect to morphological

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Shuch, Brian, Lambros Stamatakis, Clara Chen, et al. "Utility of 2-(18F) fluoro-2 deoxy-D-glucose PET/CT in advanced papillary renal cell carcinoma." Journal of Clinical Oncology 32, no. 4_suppl (2014): 419. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.419.

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419 Background: 2-(18F) fluoro-2 deoxy-D-glucose (FDG) PET/CT is used infrequently in renal cell carcinoma (RCC) based on modest sensitivity in patients with clear cell kidney cancer. We evaluated the ability of FDG PET/CT to identify metastatic kidney cancer in patients with the second most common variant, papillary RCC. Materials and Methods: Patients with papillary RCC who underwent FDG PET/CT in conjunction with anatomic imaging were identified in a review of our clinical database. The ability of FDG PET/CT to detect malignant lesions (categorized by radiographic criteria) was evaluated. R

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Odalovic, Strahinja, Dragana Sobic-Saranovic, Smiljana Pavlovic, et al. "Preliminary experience with 18f-fluoro-deoxy-glucose positron emission tomography/computed tomography in pediatric oncology patients." Acta chirurgica Iugoslavica 58, no. 4 (2011): 67–73. http://dx.doi.org/10.2298/aci1104067o.

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The aim of this study was to present preliminary experience with FDG PET/CT in pediatric oncology patients in National PET Center, Clinical Center of Serbia and to asses its impact on management of malignancies in children. 33 FDG PET /CT scans were performed on 30 pediatric patients. PET/CT imaging was performed for staging the disease, assessing therapy efficacy and diagnosing recurrent or metastatic disease. FDG PET/CT changed the stage of the disease in 60.6 % (20/33) of the cases. 14 patients were down-staged after PET/CT, mostly patients with Hodgkin?s disease, were in 7/10 cases PET/CT

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Kumar, Ananyaa, Csaba Juhász, Aimee Luat, et al. "Evolution of Brain Glucose Metabolic Abnormalities in Children With Epilepsy and SCN1A Gene Variants." Journal of Child Neurology 33, no. 13 (2018): 832–36. http://dx.doi.org/10.1177/0883073818796373.

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Three children with drug-refractory epilepsy, normal magnetic resonance image (MRI), and a heterozygous SCN1A variant underwent 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography (FDG-PET) scanning between age 6 months and 1 year and then at age 3 years 6 months to 5 years 5 months. Regional FDG uptake values were compared to those measured in age- and gender-matched pseudo-controls. At baseline, the brain glucose metabolic pattern in the SCN1A group was similar to that of the pseudo-controls. At follow-up, robust decreases of normalized FDG uptake was found in bilateral frontal, par

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