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1

Christ, Stefan [Verfasser], and Ulrich [Akademischer Betreuer] Mühlenhoff. "Analyse von posttranslationalen Modifikationen an Fe/S-Proteinen und Protein-Protein-Interaktionen zwischen Fe/S-Assemblierungsfaktoren in Mitochondrien von S. cerevisiae / Stefan Christ. Betreuer: Ulrich Mühlenhoff." Marburg : Philipps-Universität Marburg, 2016. http://d-nb.info/1099594308/34.

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2

Molik, Sabine. "Das plastidäre Rieske Fe/S-Protein Analyse des Transport- und Assemblierungsprozesses /." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975694057.

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3

Salter, A. Hugh. "Genetics and biogensis of the pea chloroplast Rieske Fe-S protein." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335798.

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4

Jayawardhana, W. Geethamala Dhananjalee. "Investigation of the Influence of Transition Metal Ions on the Fe-S Cluster Biosynthesis Protein SufU." Bowling Green State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1448034834.

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5

Salameh, Myriam. "CISD2, protéine à centre Fe-S impliquée dans différentes pathologies humaines New Insights of the NEET Protein CISD2 Reveals Distinct Features Compared to Its Close Mitochondrial Homolog mitoNEET." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASL025.

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CISD2 appartient à la famille de protéines NEET caractérisée par une coordination atypique de leur centre [2Fe-2S] par trois cystéines et une histidine, et leur capacité à transférer leur centre [Fe-S] in vitro vers une protéine acceptrice. CISD2 est une protéine homodimérique ancrée au niveau des sites de contact entre le réticulum endoplasmique et la mitochondrie avec un centre [2Fe-2S] par protomère. La majeure partie de CISD2, dont son domaine de coordination du centre [Fe-S], est cytosolique. Ce dernier est très proche en séquence et en structure de celui de mitoNEET, autre membre de la f
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Mons, Cécile. "Etude biochimique de mitoNEET humaine, protéine à centre [2Fe-2S], impliquée dans une voie de réparation des protéines Fe-S suite à un stress oxydatif." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS409.

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Présente chez les mammifères, mitoNEET (mNT) est une protéine à centre Fe-S ancrée à la membrane externe de la mitochondrie. Cette protéine dimérique possède un centre [2Fe-2S] par monomère lié de façon atypique à la protéine par trois cystéines et une histidine. Notre équipe a auparavant montré l’implication de mNT dans une nouvelle voie de réparation du centre [4Fe-4S] de l’Iron Regulatory Protein-1 (IRP-1), régulateur majeur de l’homéostasie du fer intracellulaire, par transfert du centre Fe-S de mNT à l’IRP-1 à réparer. Au cours de ma thèse, je me suis focalisée sur la caractérisation in v
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7

Leipuviene, Ramune. "Frameshifting as a tool in analysis of transfer RNA modification and translation." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-302.

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Studies of ribosomal reading frame maintenance are often based on frameshift mutation suppression experiments. In this thesis, suppression of a frameshift mutation in Salmonella enterica serovar Typhimurium by a tRNA and a ribosomal protein are described. The +1 frameshift mutation hisC3072 (that contains an extra G in a run of Gs) is corrected by mutations in the argU gene coding for the minor tRNAArgmnm5UCU. The altered tRNAArgmnm5UCU has a decreased stability and reduced aminoacylation due to changed secondary and/or tertiary structure. Protein sequencing revealed that during the translatio
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8

Reinhard, Annegret S. [Verfasser]. "Mössbauer-Spektroskopie- und Dichte-Funktional-Theorie-Untersuchungen an Modellkomplexen der [Fe]-Hydrogenase und dem Protein LytB / Annegret S. Reinhard." Aachen : Shaker, 2012. http://d-nb.info/1051576075/34.

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9

Amela, Abellan Isaac. "Bioinformatics Approaches to Protein Interaction and Complexes: Application to Pathogen-Host Epitope Mimicry and to Fe-S Cluster Biogenesis Model." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/125908.

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Les interaccions antigen/anticòs són un dels tipus més interessants d’interaccions proteiques. La millor manera de prevenir les malalties causades per patògens és mitjançant l’ús de vacunes. L’aparició de la genòmica permet fer cerques a tot el genoma de nous candidats vacunals, tècnica anomenada vaccinologia inversa. L’estratègia més comuna on s’aplica la vaccinologia inversa és al disseny de vacunes de subunitats recombinants, que en general generen resposta immune humoral a causa de la presència d’epítops B en les proteïnes del patogen. Un problema important d’aquesta estratègia és la ident
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10

Bian, Shumin. "Fe-S proteins : cluster assembly and degradation /." The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487952208109007.

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11

Beilschmidt, Lena Kristina. "Evidences for the non-redundant function of A-type proteins ISCA1 and ISCA2 in iron-sulfur cluster biogenesis." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ031/document.

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Les centres fer-soufre (Fe-S) sont des cofacteurs protéiques essentiels qui participent à un nombre important de fonctions cellulaires allant du métabolisme de l’ADN à la respiration mitochondriale. L’assemblage des centres Fe-S et leur insertion dans des protéines acceptrices requièrent l’activité d’une machinerie protéique dédiée. Bien que les protéines de la biogenèse des centres Fe-S soient conservées, plusieurs aspects fonctionnels et mécanistiques restent inconnus. Notre travail de thèse a consisté à caractériser les protéines mammifères de type A, ISCA1 et ISCA2, qui sont impliquées dan
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12

Nuth, Manunya. "Mechanism of Fe-S cluster biosynthesis the [2Fe-2S] IscU as a model scaffold /." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1092856116.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Document formatted into pages. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Aug. 18.
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13

Prohl, Corinna. "Die Funktion des mitochondrialen ABC-Transporters Atm1p und anderer Proteine bei der Reifung cytosolischer Fe-S-Proteine in Saccharomyces cerevisiae." [S.l. : s.n.], 2000. http://archiv.ub.uni-marburg.de/diss/z2001/0068/.

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14

Stümpfig, Claudia [Verfasser], and Roland [Akademischer Betreuer] Lill. "Funktionelle Defekte der humanen Proteine ISCA1, ISCA2 und IBA57 beeinträchtigen die Reifung mitochondrialer Fe/S-Proteine und führen zu mitochondrialen Erkrankungen / Claudia Stümpfig. Betreuer: Roland Lill." Marburg : Philipps-Universität Marburg, 2015. http://d-nb.info/1069375187/34.

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15

Kungel, Jana [Verfasser], Ralf Bernd [Gutachter] Klösgen, Kristina [Gutachter] Kühn, and Karin [Gutachter] Krupinska. "Transport- und Assemblierungsverhalten der Rieske Fe/S-Proteine in Chloroplasten und Mitochondrien / Jana Kungel ; Gutachter: Ralf Bernd Klösgen, Kristina Kühn, Karin Krupinska." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2020. http://d-nb.info/1230475982/34.

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16

Kirchberg, Janine [Verfasser], Gary [Akademischer Betreuer] Sawer, Daniela [Akademischer Betreuer] Büttner, and F. [Akademischer Betreuer] Börnke. "Die Rolle der Aconitasen als Fe-S-Proteine im Citrat- und Eisenstoffwechsel des phytopathogenen Bakteriums Xanthomonas campestris pv. vesicatoria / Janine Kirchberg. Betreuer: Gary Sawer ; Daniela Büttner ; F. Börnke." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2014. http://d-nb.info/1052221076/34.

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17

Chang, Fu-Ming, and 張富茗. "The functional study of NADH dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7) subunit." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/42951432985652303444.

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碩士<br>國立清華大學<br>分子醫學研究所<br>101<br>NADH dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7) is one of the nuclear-encoded and highly conserved core subunits of mitochondrial complex I. This protein houses the tetranuclear iron-sulfur cluster N2, which is the terminal receptor of electrons and the reducer for quinone in complex I peripheral arm. NDUFS7 protein plays a critical role in complex I assembly and activity, according to the results of studies from simple organisms and human disease models. Mutations of NDUFS7 have been associated with Leigh Syndrome and bipolar disorder. To detailedly i
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18

Wu, Jian Shian, and 吳建賢. "Sumoylation of Human NADH dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7) by SUMO-1." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/10504655345694324867.

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碩士<br>國立清華大學<br>分子醫學研究所<br>101<br>Human NADH dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7) is one of the most conserved core subunits of mitochondrial complex I. NDUFS7 has a bound iron-sulfur cluster N2 (tetranuclear) which is the terminal redox center in the electron transport chain (ETC) of complex I. NDUFS7 protein is encoded by the nuclear genome and is incorporated in the peripheral segment of complex I. Most mitochondrial matrix proteins are synthesized in the cytosol and imported into mitochondria by mitochondrial targeting sequences (MTSs). We previously defined the N terminus of
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19

Molik, Sabine [Verfasser]. "Das plastidäre Rieske Fe/S-Protein : Analyse des Transport- und Assemblierungsprozesses / von Sabine Molik." 2005. http://d-nb.info/975694057/34.

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20

Yang, Jia shin, and 楊佳欣. "Phosphorylation of Human NADH dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7) by c-Src." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/35833250274081088716.

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碩士<br>國立清華大學<br>分子醫學研究所<br>103<br>Human NADH dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7), participating in the process of oxidative phosphorylation (OXPHOS), is one of the most conserved core subunits of mitochondrial complex I. In addition to containing a mitochondrial targeting sequence (MTS), a functional nuclear localization signal (NLS) and a nuclear export signal (NES) are both demonstrated to be present in NDUFS7. Deficiency of NDUFS7 is associated with Leigh syndrome (LS) and patients suffering from this disease develop movement disorders and other serious complications. Thus, c
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21

BASU, Somsuvro. "Erv1 associated mitochondrial import-export pathway and the cytosolic iron-sulfur protein assembly machinery in Trypanosoma brucei." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-175336.

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This thesis highlights a divergent mitochondrial intermembrane assembly pathway in the parasitic protist Trypanosoma brucei. A comparative genomic study reveals the connection of Erv1 with the cytosolic iron-sulfur protein assembly (CIA) pathway in trypanosomatids. Further, the CIA machinery of T. brucei has been described using RNAi interference and other biochemical and complementation assays. Finally, part of the divergent CIA machinery has been identified in the human intestinal pathogen Giardia intestinalis by means of complementation assays in T. brucei.
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22

Saha, Prasenjit Prasad. "Uncovering the Role of Mitochondrial Iron-sulfur (Fe-S) Cluster Biogenesis in Human Health and Disease." Thesis, 2015. http://etd.iisc.ernet.in/2005/4002.

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Mitochondrial dysfunction has been implicated for a wide range of human diseases. One of the major biosynthetic processes in human mitochondria is the biogenesis of Iron-Sulfur (Fe-S) clusters which primarily involves in electron transfer reactions during oxidative phosphorylation (OXPHOS). Defects in Fe-S cluster biogenesis process leads to mitochondrial dysfunction and that eventually results in various human mitochondrial disorders. One of the major mitochondrial disorders associated with Fe-S cluster biogenesis impairment is exercise intolerance disorder ISCU myopathy, which is a result
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23

HSIEH, JUNG-SHENG, and 謝鎔聲. "Sumoylation of human mitochondrial NADH dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7) and the effect on its subcellular localization." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/d52k8k.

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24

Yao, Li Hsin, and 姚莉歆. "Sumoylation of human mitochondrial NADH dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7) and its association with various stress responses." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/08302812121819730701.

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碩士<br>國立清華大學<br>分子醫學研究所<br>103<br>Human NADH dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7) is one of 44 subunits in mitochondrial complex I. The N-terminal 1-60 amino acids of NDUFS7 have been defined as a mitochondrial targeting sequence (MTS) and the C-terminus contains a nuclear localization signal (NLS) and a nuclear export signal (NES). The sequence of NDUFS7 is highly conserved in the motif: CCXXE(X)60C(X)30CP. It can bind to an iron-sulfur cluster (a [4Fe-4S] cluster) called N2, a redox center in the terminus of complex I electron transfer pathway. In previous study, we identified
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25

Chang, Juan-Yu, and 張絹鈺. "The functional study of mitochondrial NADH dehydrogenase (ubiquinone) Fe-S protein 8 and characterization of its mitochondrial targeting sequence." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/65826221666303294182.

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碩士<br>國立清華大學<br>分子醫學研究所<br>98<br>Oxidative phosphorylation system in mammalian cells contains five enzyme complexes. Among them, mitochondrial complex I is the biggest and the most complicated, with many undefined subunits and has no resolved complete structure. Mammalian mitochondrial complex I comprises of forty-five subunits, and seven of them are encoded by the mitochondrial genome. The remaining subunits are encoded by the nuclear genome and imported into mitochondria to perform their functions. NADH dehydrogenase (ubiquinone) Fe-S protein 8 (NDUFS8) is one of the nuclear-encoded mitochon
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26

Vacek, Vojtěch. "Syntéza železo-sirných center v Monocercomonoides exilis." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-437064.

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In the search for the mitochondrion of oxymonads, DNA of Monocercomonoides exilis - an oxymonad isolated from the gut of Chinchilla, was isolated and its genome was sequenced. Sequencing resulted in a fairly complete genome which was extensively searched or genes for mitochondrion related proteins, but no reliable candidate for such gene was identified. Even genes for the ISC pathway, which is responsible for Fe-S cluster assembly and considered to be the only essential function of reduced mitochondrion-like organelles (MROs), were absent. Instead, we were able to detect the presence of a SUF
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27

吳珮玉. "The functional analysis of NADH dehydrogenase (ubiquinone) Fe-S protein 8 (NDUFS8) subunit and its iron-sulfur clusters in human mitochondrial complex I." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/85222579117160475992.

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28

Lin, Bo-Yu, and 林伯諭. "Studies on targeting NADH dehydrogenase (ubiquinone) Fe-S protein 8 to mitochondria by HIV-transactivator of transcription and rescuing mitochondrial complex I deficiency." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/92016889909079546348.

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碩士<br>國立清華大學<br>分子醫學研究所<br>101<br>Defects in subunits of mitochondrial complex I are associated with severe diseases, including Leber hereditary optic neuropathy and Leigh syndrome. However, to date, conventional treatment for the majority of genetic-based mitochondrial diseases can only be palliative. Therefore, developing a reliable and convenient treatment approach is in an urgent need. Fusion of the protein transduction domain (PTD) of HIV-1 transactivator of transcription (TAT) with proteins has been demonstrated to bring proteins into cells by crossing plasma membranes while retaining th
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29

Huang, Zi Xuan, and 黃子軒. "Functional study of NADH dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7) and the effect of its deficiency on the assembly of mitochondrial OXPHOS complexes." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/33125566436403079182.

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碩士<br>國立清華大學<br>分子醫學研究所<br>104<br>NADH-dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7), a highly conserved protein encoded by the nuclear DNA, is one of the core subunits in the mitochondrial NADH-coenzyme Q oxidoreductase (Complex I). It contains a tetranuclear iron-sulfur cluster N2 that assists electron transfer and serves as the final electron donor for ubiquinone and thus contributes to energy generation in the oxidative phosphorylation (OXPHOS) system. Mutations in NDUFS7 have been reported in patients suffering from neurodegenerative diseases such as Leigh syndrome and might also bee
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30

Mach, Jan. "Funkce mitochondrie při maturaci Fe-S proteinů Trypanosoma brucei." Master's thesis, 2008. http://www.nusl.cz/ntk/nusl-292029.

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31

CHANGMAI, Piya. "Formation of Fe-S clusters in the mitochondrion of Trypanosoma brucei." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-156659.

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This thesis focuses on iron sulfur (Fe-S) cluster biogenesis by the ISC machinery in the mitochondrion of Trypanosoma brucei. Most of proteins in the pathway show conserved functions, while some features are distinct from their counterparts in other organisms. We also show here the essentiality of the ISC machinery in bloodstream stage despite the fact that the parasites contain the rudimentary mitochondrion in this stage. The key player for the ISC export machinery, which is indispensable in the maturation of extra-mitochondrial Fe-S proteins, shows some extraordinary phenomena which may impl
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32

SKALICKÝ, Tomáš. "Functional analysis of Ssc1 and Iba57 proteins in \kur{Trypanosoma brucei}." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-54886.

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Aim of this thesis was to shed light on the function(s) of Iba57 and Ssc1 proteins in both life cycle stages of T. brucei using RNA interference. Depletion of Ssc1 resulted in severe grow phenotype, decrease in activities of iron-sulphur cluster-containing enzyme aconitase but no increase in oxidative stress sensitivity or accumulation of ROS in mitochondrion. Down regulation of Iba57, specialized maturation factor of aconitase and homoaconitase, lead to depletion of aconitase, destabilization of Isa1 and increased sensitivity to oxidative stress and accumulation of ROS in both stages.
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33

Prohl, Corinna [Verfasser]. "Die Funktion des mitochondrialen ABC-Transporters Atm1p und anderer Proteine bei der Reifung cytosolischer Fe-S-Proteine in Saccharomyces cerevisiae / vorgelegt von Corinna Prohl." 2000. http://d-nb.info/971946019/34.

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