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1

Klastersky, J. Febrile neutropenia. London: Springer Healthcare, 2014.

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2

Klastersky, Jean A., ed. Febrile Neutropenia. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60443-0.

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3

Klastersky, Jean A. Febrile Neutropenia. Tarporley: Springer Healthcare Ltd., 2014. http://dx.doi.org/10.1007/978-1-907673-70-2.

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4

Febrile Neutropenia. Springer, 2012.

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5

J, Klastersky, ed. Febrile neutropenia. Berlin: Springer, 1997.

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6

Kenneth V I Rolston (Editor) and Edward B. Rubenstein (Editor), eds. Textbook of Febrile Neutropenia. Informa Healthcare, 2001.

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7

I, Rolston Kenneth V., and Rubenstein Edward B, eds. Textbook of febrile neutropenia. London: Martin Dunitz, 2001.

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8

Textbook of Febrile Neutropenia. Abingdon, UK: Taylor & Francis, 1988. http://dx.doi.org/10.4324/9780203215272.

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9

Champigneulle, Benoit, and Frédéric Pène. Pathophysiology and management of neutropenia in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0274.

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Neutropenia is defined by an absolute neutrophil count <500 per mm3. Chemotherapy-induced myelosuppression represents the main mechanism accounting for neutropenia, although various bone marrow disorders might also result in impaired granulopoiesis. Neutropenia, especially when profound and prolonged, is a major risk factor for severe bacterial and fungal infections. Early initiation of empirical broad-spectrum antibiotic therapy represents the cornerstone of the treatment of febrile neutropenia. A number of infected neutropenic patients may exhibit organ failures, such as acute respiratory failures and/or severe sepsis requiring intensive care unit (ICU) admission. This chapter discusses the particularities in the management of neutropenic patients in the ICU, including outcome and criteria for ICU admission, management of antimicrobials with respect to the current epidemiological trends, and other measures specific to this subgroup of patients.
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10

Ison, Michael G. Upper Respiratory Symptoms During Febrile Neutropenia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199938568.003.0012.

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These case studies illustrate infections encountered in hospitals among patients with compromised immune systems. As a result of immunocompromise, the patients are vulnerable to common and uncommon infections. These cases are carefully chosen to reflect the most frequently encountered infections in the patient population, with an emphasis on illustrations and lucid presentations to explain state-of-the-art approaches in diagnosis and treatment. Common and uncommon presentations of infections are presented while the rare ones are not emphasized. The cases are written and edited by clinicians and experts in the field. Each of these cases highlights the immune dysfunction that uniquely predisposed the patient to the specific infection, and the cases deal with infections in the cancer patient, infections in the solid organ transplant recipient, infections in the stem cell recipient, infections in patients receiving immunosuppressive drugs, and infections in patients with immunocompromise that is caused by miscellaneous conditions.
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11

Wilson, John W., and Lynn L. Estes. Management of the Febrile Neutropenic Patient. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199797783.003.0120.

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•Fever: Single oral temperature of ≥38.3°C (101°F) or a temperature of ≥38.0°C (100.4°F) for ≥1 hour•Neutropenia: A neutrophil count of <500 cells/mm3 or one that is expected to fall below 500/mm3 over the next 48 hours• Bacteria• Enterobacteriaceae (eg, ...
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12

Chan, Betty P. Evaluation of the febrile neutropenic protocol at the Toronto Hospital. 1998.

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13

WONG, CECILE M. VALIDATION OF THE DOSING GUIDELINES FOR ONCE-DAILY GENTAMICIN FOR FEBRILE NEUTROPENIC CHILDREN. UNIVERSITY OF TORONTO, 2004, 2004.

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14

Dumo, Peter A. Development of a database on antimicrobial prescribing and resistance patterns amongst febrile neutropenic hematology patients. 1995.

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15

Howe, Christine K. An assessment of an antibiotic treatment algorithm for chemotherapy-induced febrile neutropenia: prescribing congruence and patient outcomes. 2003, 2003.

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16

Zhu, Nancy Y., and Cynthia Wu. Anaemia, cytopenias, and thrombosis in palliative medicine. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0083.

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Many haematological issues can complicate end-of-life care, including cytopenias and venous thromboembolism (VTE). Anaemia is very common and can significantly impact quality of life; causes include haemorrhage, iron deficiency, nutritional deficiencies, and bone marrow infiltration. Neutropenia from bone marrow failure as a result of disease infiltration or from chemotherapy effects can result in life-threatening infections. Finally, VTE is commonly seen in cancer patients as well as those who require prolonged hospitalization. Symptoms can cause discomfort, mortality is increased, and treatment is associated with major bleeding. Understanding the therapeutic options and their adverse side effects is essential in the management of these complex problems. Despite the presence of effective therapies, it is also important to realize that events such as febrile neutropenia and pulmonary embolism are often seen at the end of life and intervention may not always impact prognosis. The risks of intervention should be weighed against expected benefits when developing appropriate palliative care plans.
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17

Ozon, Lynn. A retrospective analysis of febrile neutropenia in patients with multiple myeloma and lymphoma treated with high-dose chemotherapy and autologous bone marrow transplant in the outpatient setting. c2003, 2003.

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18

Wilson, A. P. R., and Preet Panesar. Antimicrobial drugs in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0053.

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The pharmacokinetics of antimicrobials are altered in critically-ill patients, particularly in the presence of renal or hepatic failure. Maintaining a choice or diversity of antibiotics is important due to the emergence of resistance. Antibiotic use should also be kept to the minimum and local protocols need to be established. For community-acquired infection, co-amoxiclav or a parenteral cephalosporin can be used, while for hospital-acquired infection, piperacillin/tazobactam, ciprofloxacin, or ceftazidime are recommended. For suspected vascular catheter infection or methicillin-resistant Staphylococcus aureus (MRSA) infection, teicoplanin or vancomycin should be used, with meropenem or imipenem reserved for second line treatment. Prophylactic antibiotics should not be continued once a surgical patient has returned from the theatre. Patients with febrile neutropenia receive piptazobactam, meropenem, ceftazidime or ciprofloxacin and a glycopeptide. Antifungals, usually caspofungin or liposomal amphotericin, are used if fungal infection is suspected, especially after failed antibacterial treatment. Cephalosporin use has declined as they have been linked with emergence of MRSA and Clostridium difficile. However, this reflects overuse and they still have a place as part of a diverse choice of antibiotics. Vancomycin and teicoplanin use has increased greatly in order to treat MRSA and line infections, but resistance remains unusual. Carbapenem use has increased rapidly with the emergence of extended spectrum beta-lactamase producing Gram-negative bacteria.
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