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Journal articles on the topic 'Fecal biomarker'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Kamel, Y. S. "Increased Fecal Calprotectin Levels in Crohn’s Disease Correlate with Elevated Serum Th1- and Th17-Associated Cytokines." American Journal of Clinical Pathology 154, Supplement_1 (2020): S119—S120. http://dx.doi.org/10.1093/ajcp/aqaa161.261.

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Abstract Introduction/Objective Patient-reported symptoms and endoscopic disease activity do not correlate well in Crohn’s disease (CD). This warrants the need for reliable biomarkers to early detect active intestinal inflammation. Currently, the fecal calprotectin level is the most commonly used biomarker for inflammatory activity in CD. However, the diagnostic accuracy of the fecal calprotectin level is not fully efficacious and diagnosis may be further improved by the identification of other biomarkers for active CD. Here, we studied the association of a variety of serum disease markers wit

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Fengming, Yi, and Wu Jianbing. "Biomarkers of Inflammatory Bowel Disease." Disease Markers 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/710915.

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Inflammatory bowel disease (IBD) is a chronic disease mostly involved with intestine with unknown etiology. Diagnosis, evaluation of severity, and prognosis are still present as challenges for physicians. An ideal biomarker with the characters such as simple, easy to perform, noninvasive or microinvasive, cheap, rapid, and reproducible is helpful for patients and clinicians. Currently biomarkers applied in clinic include CRP, ESR, pANCA, ASCA, and fecal calprotectin. However, they are far from ideal. Lots of studies are focused on seeking for ideal biomarker for IBD. Herein, the paper reviewed

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Schaebs, Franka S., Tanja E. Wolf, Verena Behringer, and Tobias Deschner. "Fecal thyroid hormones allow for the noninvasive monitoring of energy intake in capuchin monkeys." Journal of Endocrinology 231, no. 1 (2016): 1–10. http://dx.doi.org/10.1530/joe-16-0152.

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Measuring energetic condition of wild animals is of major importance in ecological research, as it is profoundly linked to fitness. However, noninvasive monitoring of energetic condition in wild-living animals is methodologically challenging. Measuring urinary C-peptide levels is a suitable method to noninvasively assess energy balance in wild-living animals. As collecting urine is not always feasible in the wild, it is essential to establish alternative biomarkers for other sample types to assess energy balance. Thyroid hormones (TH) are potential candidates as they are involved in the regula

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Yildiz, Alp, Huseyin Gobut, Sezai Leventoglu, et al. "Septin-9: a novel biomarker for colorectal cancer screening." International Surgery Journal 6, no. 2 (2019): 355. http://dx.doi.org/10.18203/2349-2902.isj20190382.

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Background: The gold standard method for the diagnosis of colorectal cancer is colonoscopy. However, colonoscopy has several limitations and complications. Moreover, fecal occult blood test and serum based tumor markers do lack the desired specificity and sensitivity. Therefore, a novel biomarker is needed for early detection of colorectal cancer. With this prospective randomised controlled study author’s aim was to evaluate the efficacy of Septin-9 on colorectal cancer screening.Methods: Septin-9 is a protein which is encoded by the SEPT9 gene. SEPT9 has been detected in the blood of colorect

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Wright, Emily K. "Calprotectin or Lactoferrin: Do They Help." Digestive Diseases 34, no. 1-2 (2016): 98–104. http://dx.doi.org/10.1159/000442935.

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Background: The diagnosis and monitoring of inflammatory bowel disease (IBD) has traditionally relied on clinical assessment, serum markers of inflammation and endoscopic examination. Fecal biomarkers such as calprotectin (FC) and lactoferrin (FL) are predominantly derived from neutrophils, are easily detectable in the feces and are now established as valuable markers of intestinal inflammation. In recent years, a ‘treat to target' concept has emerged for the management of IBD. Adequate control of inflammation in IBD at a biochemical level is quickly becoming an important target in IBD managem

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Bodelier, Alexander, Tim Van den Heuvel, Ingeborg Bovee-Oudenhoven, et al. "Fecal Pancreatitis-Associated Protein: A Novel Biomarker in IBD?" Gastroenterology 140, no. 5 (2011): S—423. http://dx.doi.org/10.1016/s0016-5085(11)61738-1.

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7

Jiang, Zhi-dong, Kevin Garey, Todd Lasco, and Herbert Dupont. "Fecal Calprotectin as a Biomarker for Clostridium Difficile Infection." American Journal of Gastroenterology 111 (October 2016): S67. http://dx.doi.org/10.14309/00000434-201610001-00141.

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Kato, Jun, Sakiko Hiraoka, Asuka Nakarai, Shiho Takashima, Toshihiro Inokuchi, and Masao Ichinose. "Fecal immunochemical test as a biomarker for inflammatory bowel diseases: can it rival fecal calprotectin?" Intestinal Research 14, no. 1 (2016): 5. http://dx.doi.org/10.5217/ir.2016.14.1.5.

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Hsieh, Heidi, Jeffrey Morin, Cyndi Filliettaz, Rao Varada, Shelby LaBarre, and Zaher Radi. "Fecal Lipocalin-2 as a Sensitive and Noninvasive Biomarker in the TNBS Crohn’s Inflammatory Bowel Disease Model." Toxicologic Pathology 44, no. 8 (2016): 1084–94. http://dx.doi.org/10.1177/0192623316665927.

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Colitis induced by 2,4,6-Trinitrobenzenesulfonic acid (TNBS) has been used as a model for Crohn’s disease (CD) of inflammatory bowel disease (IBD). Lipocalin-2 (Lcn-2) is an emerging and clinically relevant biomarker of IBD. We investigated the performance of serum and fecal Lcn-2 in the TNBS model of colitis. Female, 7-week-old, BALB/c mice were administered intrarectally phosphate-buffered saline/water or 30% ethanol (vehicle control groups) for 5 days or TNBS for 5 days followed by a 28-day recovery phase. Serum and fecal levels of Lcn-2 were quantified, and effects on body weight, clinical

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Jovanovic, Milan, Nevena Gajovic, Natasa Zdravkovic, et al. "Fecal Galectin-3: A New Promising Biomarker for Severity and Progression of Colorectal Carcinoma." Mediators of Inflammation 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/8031328.

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Background and Objectives. The aim of the study was to determine systemic and fecal values of galectin-3 and pro- and anti-inflammatory cytokines in patients with CRC and the relationship with clinicopathological aspects. Methods. Concentrations of galectin-3, TNF-α, TGF-β, IL-10, and IL-1β were analyzed in samples of blood and stool of 60 patients with CRC. Results. Systemic concentration of TNF-α was significantly lower in patients with severe diseases (advanced TNM stage, nuclear grade, and poor histological differentiation) as in patients with more progressive CRC (lymph and blood vessel i

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Porter, Amy C., Jiri Aubrecht, Chandler Birch, et al. "Biomarkers of Crohn’s Disease to Support the Development of New Therapeutic Interventions." Inflammatory Bowel Diseases 26, no. 10 (2020): 1498–508. http://dx.doi.org/10.1093/ibd/izaa215.

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Abstract Background Currently, 2 coprimary end points are used by health authorities to determine the effectiveness of therapeutic interventions in patients with Crohn’s disease (CD): symptomatic remission (patient-reported outcome assessment) and endoscopic remission (ileocolonoscopy). However, there is lack of accepted biomarkers to facilitate regulatory decision-making in the development of novel therapeutics for the treatment of CD. Methods With support from the Helmsley Charitable Trust, Critical Path Institute formed the Crohn’s Disease Biomarkers preconsortium (CDBpC) with members from

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Barré, Amélie, Leonid Tarassishin, Caroline Eisele, et al. "Su1792 - Fecal Lactoferrin is a Reliable IBD Biomarker During Pregnancy." Gastroenterology 154, no. 6 (2018): S—585—S—586. http://dx.doi.org/10.1016/s0016-5085(18)32138-3.

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Pearson, Jennifer R., Chris IR Gill, and Ian R. Rowland. "Diet, fecal water, and colon cancer - development of a biomarker." Nutrition Reviews 67, no. 9 (2009): 509–26. http://dx.doi.org/10.1111/j.1753-4887.2009.00224.x.

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Kunte, Dhananjay, Suzana Savkovic, Wentao Qi, Mart de la Cruz, Ramesh Wali, and Hemant Roy. "miR-34a as potential fecal biomarker Colitis-induced Colorectal cancer." Inflammatory Bowel Diseases 17 (December 2011): S86—S87. http://dx.doi.org/10.1097/00054725-201112002-00287.

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15

Buderus, Stephan, James H. Boone, and Michael J. Lentze. "Fecal Lactoferrin: Reliable Biomarker for Intestinal Inflammation in Pediatric IBD." Gastroenterology Research and Practice 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/578527.

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Background. Optimal management of pediatric patients with inflammatory bowel disease (IBD) requires early diagnosis. Aim of the study is to compare fecal lactoferrin (FL) as biomarker of intestinal inflammation to CRP in pediatric patients with new-onset IBD.Methods. FL was measured by ELISA in stool specimens collected prior to endoscopy for IBD (IBD-SCAN; TechLab, Blacksburg; normal < 7.3 µg/g feces). CRP was detected in serum (normal < 5 mg/L). Three patient groups were determined:n=21(mean age 13.2) with Crohn’s disease (CD),n=15(mean age 10.9) with ulcerative colitis (UC), andn=20(m

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Chappell, Cynthia L., Charles Darkoh, Lawrence Shimmin, et al. "Fecal Indole as a Biomarker of Susceptibility to Cryptosporidium Infection." Infection and Immunity 84, no. 8 (2016): 2299–306. http://dx.doi.org/10.1128/iai.00336-16.

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Cryptosporidiumcauses significant diarrhea worldwide, especially among children and immunocompromised individuals, and no effective drug treatment is currently available for those who need it most. In this report, previous volunteer infectivity studies have been extended to examine the association between fecal indole and indole-producing (IP) gut microbiota on the outcome of aCryptosporidiuminfection. Fecal indole concentrations (FICs) of 50 subjects and 19 taxa of common gut microbiota, including six IP taxa (11 subjects) were determined in stool samples collected before and after a challeng

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Chen, Zhenshan, Anasthasia Krieger, Yu Liu, John Ross, and Robert Krieger. "Fecal DDA as a biomarker of DDT exposure in chickens." Toxicological & Environmental Chemistry 97, no. 7 (2015): 946–60. http://dx.doi.org/10.1080/02772248.2015.1074388.

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18

Langhorst, J., and J. Boone. "Fecal lactoferrin as a noninvasive biomarker in inflammatory bowel diseases." Drugs of Today 48, no. 2 (2012): 149. http://dx.doi.org/10.1358/dot.2012.48.2.1732555.

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Mortensen, J., M. A. Karsdal, H. Grønbæk, C. L. Hvas, A. Dige та A. C. Bay-Jensen. "P316 Human neutrophil elastase derived fragment of calprotectin (S100a9) is a serum biomarker (CPa9-HNE) for monitoring of anti-TNFα treatment response in Crohn’s disease". Journal of Crohn's and Colitis 15, Supplement_1 (2021): S342—S343. http://dx.doi.org/10.1093/ecco-jcc/jjab076.440.

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Abstract Background In patients with inflammatory bowel disease (IBD), up to 30% do not achieve response, 66% do not achieve remission, and 40% experience loss of response to anti-TNFα treatment. In Crohn’s disease (CD), fecal calprotectin is the most widely used fecal biomarker for diagnosis and monitoring of disease activity. Fecal sampling and processing are tedious compared to serum sampling, and biomarker quantification in serum is more efficient, convenient, and also more acceptable for patients. Therefore, there is a need for a robust and reliable serum calprotectin biomarker that perfo

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Harder, B., E. Casavant, J. McBride, et al. "P052 Comprehensive proteomic profiling of stool from UC and CD patients reveals expected and novel mucosal pathobiology, enabling identification of candidate non-invasive biomarkers to monitor mucosal disease activity." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S160. http://dx.doi.org/10.1093/ecco-jcc/jjab076.181.

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Abstract Background Inflammatory bowel disease (IBD) is a multifactorial disorder characterized by chronic gastrointestinal (GI) inflammation. In clinical practice, physicians urgently need biomarkers to monitor changes in mucosal disease to manage treatment. Non-invasive tools such as fecal biomarkers could allow for frequent monitoring of mucosal disease activity and may reflect inflammation of the entire GI tract. Towards identification of novel non-invasive fecal biomarkers, we performed a comprehensive, unbiased, analysis of the human fecal proteome from ulcerative colitis (UC), Crohn’s d

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Sánez, Juan, Sandro Froehner, Fabrício Hansel, et al. "Bile acids combined with fecal sterols: a multiple biomarker approach for deciphering fecal pollution using river sediments." Journal of Soils and Sediments 17, no. 3 (2016): 861–72. http://dx.doi.org/10.1007/s11368-016-1592-1.

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Metafuni, Elisabetta, Patrizia Chiusolo, Silvia Bellesi, et al. "ROLE of Fecal Calprotectin as BIOMARKER of Gvhd AFTER Allogeneic STEM CELL TRANSPLANTATION." Blood 116, no. 21 (2010): 1253. http://dx.doi.org/10.1182/blood.v116.21.1253.1253.

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Abstract Abstract 1253 Introduction: Graft-versus-host disease is one of the main complications after allogeneic stem cell transplantation. Recently, some authors focused their attention on the evaluation of proteomic pattern of biologic samples, as saliva and urine, in patients affected by GHVD. The aim of these studies was to identify a highly sensitive and specific marker of GVHD activity, with a predictive and prognostic value. Several authors have investigated the role of fecal calprotectin in patients affected by inflammatory bowel disease. So, level of fecal calprotectin seems to have a

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Burri, Emanuel, and Christoph Beglinger. "The use of fecal calprotectin as a biomarker in gastrointestinal disease." Expert Review of Gastroenterology & Hepatology 8, no. 2 (2013): 197–210. http://dx.doi.org/10.1586/17474124.2014.869476.

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24

de Klaver, Willemijn, Pieter Wisse, Meike de Wit, et al. "Mo1073 NOVEL FECAL PROTEIN BIOMARKER TEST FOR IMPROVED COLORECTAL CANCER SCREENING." Gastroenterology 158, no. 6 (2020): S—779. http://dx.doi.org/10.1016/s0016-5085(20)32619-6.

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Salminen, Seppo. "Allergy Associations with the Adult Fecal Microbiota: Cause, Effect or Biomarker?" EBioMedicine 3 (January 2016): 15–16. http://dx.doi.org/10.1016/j.ebiom.2015.11.051.

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Pinto-Lopes, Pedro, Francisco Melo, Joana Afonso, et al. "Fecal Dipeptidyl Peptidase-4: An Emergent Biomarker in Inflammatory Bowel Disease." Clinical and Translational Gastroenterology 12, no. 3 (2021): e00320. http://dx.doi.org/10.14309/ctg.0000000000000320.

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Kalabat, Dalia Y., Allison Vitsky, Wesley Scott, et al. "Identification and Evaluation of Novel MicroRNA Biomarkers in Plasma and Feces Associated with Drug-induced Intestinal Toxicity." Toxicologic Pathology 45, no. 2 (2016): 302–20. http://dx.doi.org/10.1177/0192623316644992.

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Gastrointestinal toxicity is dose limiting with many therapeutic and anticancer agents. Real-time, noninvasive detection of markers of toxicity in biofluids is advantageous. Ongoing research has revealed microRNAs as potential diagnostic and predictive biomarkers for the detection of select organ toxicities. To study the potential utility of microRNA biomarkers of intestinal injury in a preclinical toxicology species, we evaluated 3 rodent models of drug-induced intestinal toxicity, each with a distinct mechanism of toxicity. MiR-215 and miR-194 were identified as putative intestinal toxicity

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Shinn, Leila, Aditya Manasharamani, Yutong Li, et al. "The Impact of Almond and Walnut Consumption on the Human Fecal Metabolome." Current Developments in Nutrition 5, Supplement_2 (2021): 1180. http://dx.doi.org/10.1093/cdn/nzab054_035.

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Abstract Objectives Metabolomic studies can be utilized to generate biomarkers of food intake. Undigested food components affect the fecal microbiota and metabolome. Accordingly, we aimed to identify fecal metabolites unique to almond and walnut consumption. Methods Untargeted metabolomic analyses were completed on 66 endpoint fecal samples from two separate 3-week randomized, controlled-feeding, crossover studies examining almond (n = 30) and walnut (n = 36) consumption in adults (25–75 yr). Control diets, representative of the typical American diet, were fed at weight maintenance with 0 g/da

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Szymanska, Edyta, Aldona Wierzbicka, Maciej Dadalski, and Jaroslaw Kierkus. "Fecal Zonulin as a Noninvasive Biomarker of Intestinal Permeability in Pediatric Patients with Inflammatory Bowel Diseases—Correlation with Disease Activity and Fecal Calprotectin." Journal of Clinical Medicine 10, no. 17 (2021): 3905. http://dx.doi.org/10.3390/jcm10173905.

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Background: Recent data indicate that increased intestinal permeability plays a key role in the pathogenesis of inflammatory bowel diseases (IBD) and correlates with disease flare. Since zonulin related proteins (ZRP) are the proteins that increase permeability in the epithelial layer of the small intestine by reversibly modulating the intercellular tight junctions, they may serve as a new, noninvasive biomarker of disease activity. The aim of this study was to investigate fecal ZRP in pediatric IBD patients as well as its correlation with disease activity and fecal calprotectin (FCP). Methods

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Zidi, Oumaima, Nessrine Souai, Henda Raies, et al. "Fecal Metabolic Profiling of Breast Cancer Patients during Neoadjuvant Chemotherapy Reveals Potential Biomarkers." Molecules 26, no. 8 (2021): 2266. http://dx.doi.org/10.3390/molecules26082266.

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Breast cancer (BC) is the most common form of cancer among women worldwide. Despite the huge advancements in its treatment, the exact etiology of breast cancer still remains unresolved. There is an increasing interest in the role of the gut microbiome in modulating the anti-cancer therapeutic response. It seems that alteration of the microbiome-derived metabolome potentially promotes carcinogenesis. Taken together, metabolomics has arisen as a fascinating new omics field to screen promising metabolic biomarkers. In this study, fecal metabolite profiling was performed using NMR spectroscopy, to

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Moles, Laura, Esperanza Escribano, Javier de Andrés, et al. "Administration ofBifidobacterium brevePS12929 andLactobacillus salivariusPS12934, Two Strains Isolated from Human Milk, to Very Low and Extremely Low Birth Weight Preterm Infants: A Pilot Study." Journal of Immunology Research 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/538171.

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The preterm infant gut has been described as immature and colonized by an aberrant microbiota. Therefore, the use of probiotics is an attractive practice in hospitals to try to reduce morbidity and mortality in this population. The objective of this pilot study was to elucidate if administration of two probiotic strains isolated from human milk to preterm infants led to their presence in feces. In addition, the evolution of a wide spectrum of immunological compounds, including the inflammatory biomarker calprotectin, in both blood and fecal samples was also assessed. For this purpose, five pre

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Morais, Juliana, Cláudia Marques, Ana Faria, et al. "Influence of Human Milk on Very Preterms’ Gut Microbiota and Alkaline Phosphatase Activity." Nutrients 13, no. 5 (2021): 1564. http://dx.doi.org/10.3390/nu13051564.

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The FEEDMI Study (NCT03663556) evaluated the influence of infant feeding (mother’s own milk (MOM), donor human milk (DHM) and formula) on the fecal microbiota composition and alkaline phosphatase (ALP) activity in extremely and very preterm infants (≤32 gestational weeks). In this observational study, preterm infants were recruited within the first 24 h after birth. Meconium and fecal samples were collected at four time points (between the 2nd and the 26th postnatal days. Fecal microbiota was analyzed by RT-PCR and by 16S rRNA sequencing. Fecal ALP activity, a proposed specific biomarker of ne

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Nomura, Kei, Dai Ishikawa, Koki Okahara, et al. "P168 BACTEROIDETES SPECIES ARE USEFUL BIOMARKER OF CLINICAL ACTIVITY IN ULCERATIVE COLITIS." Inflammatory Bowel Diseases 26, Supplement_1 (2020): S39. http://dx.doi.org/10.1093/ibd/zaa010.100.

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Abstract Background We previously reported that there were 13 species of Bacteroidetes phylum with significantly higher or lower relative abundance in patients with ulcerative colitis (UC) than healthy individuals. In this study, we investigated the correlation between Bacteroidetes species components in fecal samples and clinical evaluations of UC. Method This study included participants above 20 years of age. Fecal samples were collected for microbial analysis from 54 patients who had active UC based on a Lichtiger’s clinical activity index (CAI) ≥ 4 or an endoscopic Mayo clinic score ≥1. DN

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Tonus, Carolin. "Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK." World Journal of Gastroenterology 12, no. 43 (2006): 7007. http://dx.doi.org/10.3748/wjg.v12.i43.7007.

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Leng, Joy, Chris Proudman, Alistair Darby, et al. "Exploration of the Fecal Microbiota and Biomarker Discovery in Equine Grass Sickness." Journal of Proteome Research 17, no. 3 (2018): 1120–28. http://dx.doi.org/10.1021/acs.jproteome.7b00784.

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Knezevic Ivanovski, T., S. Knezevic Usaj, V. Gligorijevic, S. Markovic, P. Svorcan, and M. Nedeljkovic Protic. "P236 Fecal calprotectin as suitable biomarker in evaluation of histological disease activity." Journal of Crohn's and Colitis 11, suppl_1 (2017): S197—S198. http://dx.doi.org/10.1093/ecco-jcc/jjx002.361.

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Limburg, Paul J., Mary E. Devens, Jonathan J. Harrington, Nancy N. Diehl, Douglas W. Mahoney, and David A. Ahlquist. "Prospective evaluation of fecal calprotectin as a screening biomarker for colorectal neoplasia." American Journal of Gastroenterology 98, no. 10 (2003): 2299–305. http://dx.doi.org/10.1111/j.1572-0241.2003.07630.x.

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Khoshbaten, Manouchehr, Parinaz Pishahang, Mohammad Nouri, Alireza Lashkari, Mahasti Alizadeh, and Mohammad Rostami-Nejad. "Diagnostic Value of Fecal Calprotectin as a Screening Biomarker for Gastrointestinal Malignancies." Asian Pacific Journal of Cancer Prevention 15, no. 4 (2014): 1667–70. http://dx.doi.org/10.7314/apjcp.2014.15.4.1667.

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Thorsvik, Silje, Jan Kristian Damås, Atle vB Granlund, et al. "Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease." Journal of Gastroenterology and Hepatology 32, no. 1 (2017): 128–35. http://dx.doi.org/10.1111/jgh.13598.

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Saqib, Z., G. De Palma, J. Lu, P. Bercik та S. M. Collins. "A46 FECAL β-DEFENSIN LEVELS AS A RELIABLE BIOMARKER OF INTESTINAL DYSBIOSIS". Journal of the Canadian Association of Gastroenterology 2, Supplement_2 (2019): 92–93. http://dx.doi.org/10.1093/jcag/gwz006.045.

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DeLorenzo, C., B. Lynch, T. Roth, K. Petren, and E. Curry. "117 DEVELOPMENT OF A NONINVASIVE, FECAL PROTEIN PREGNANCY TEST FOR POLAR BEARS." Reproduction, Fertility and Development 28, no. 2 (2016): 188. http://dx.doi.org/10.1071/rdv28n2ab117.

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Differentiating between pregnancy and nonpregnancy noninvasively is difficult in species that experience pseudopregnancy, including polar bears (Ursus maritimus). These bears usually breed in the spring, undergo delayed implantation until late summer or early fall, and give birth in late fall. In other species, the placental protein transthyretin (TTR) has been shown to be essential for early fetal growth, responsible for transporting thyroid hormone from the mother to the fetus during early pregnancy. Preliminary data obtained via 2D-DIGE indicated that fecal TTR is elevated during polar bear

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Manoppo, Jeanette, Rizal Somali, and PITIKA ASPR. "Fecal calprotectin and its association with functional dyspepsia in children." Paediatrica Indonesiana 60, no. 2 (2020): 71–5. http://dx.doi.org/10.14238/pi60.2.2020.71-5.

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Background Calprotectin is a calcium-binding protein found normally in small amounts within the digestive tract. Fecal calprotectin measurement is used as a biomarker to identify digestive tract inflammation. Functional dyspepsia is one of the most common health issues in children, occurring in 3-27%, and accounts for considerable quality of life impairment and health care expenses. Objective To determine fecal calprotectin concentration in generally healthy children as well as to assess for a possible association between fecal calprotectin and functional dyspepsia. Methods This cr

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Manoppo, Jeanette, Rizal Somali, and PITIKA ASPR. "Fecal calprotectin and its association with functional dyspepsia in children." Paediatrica Indonesiana 60, no. 2 (2020): 72–6. http://dx.doi.org/10.14238/pi60.2.2020.72-6.

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Background Calprotectin is a calcium-binding protein found normally in small amounts within the digestive tract. Fecal calprotectin measurement is used as a biomarker to identify digestive tract inflammation. Functional dyspepsia is one of the most common health issues in children, occurring in 3-27%, and accounts for considerable quality of life impairment and health care expenses. Objective To determine fecal calprotectin concentration in generally healthy children as well as to assess for a possible association between fecal calprotectin and functional dyspepsia. Methods This cr

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Rosa, Fernanda, Tainara Cristina Michelotti, Benoit St-Pierre, Erminio Trevisi, and Johan S. Osorio. "Early Life Fecal Microbiota Transplantation in Neonatal Dairy Calves Promotes Growth Performance and Alleviates Inflammation and Oxidative Stress during Weaning." Animals 11, no. 9 (2021): 2704. http://dx.doi.org/10.3390/ani11092704.

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This study aimed to evaluate the effects of early life fecal microbiota transplantation (FMT) on the health and performance of neonatal dairy calves. The donor was selected based on health and production records and fecal material testing negative for infectious pathogens. Sixteen healthy newborn Holstein calves were randomized to either a baseline nutritional program (CON) or 1×/d inoculations with 25 g of fecal donor material (FMT) mixed in the milk replacer (n = 8/TRT) from 8 to 12 days of age. Blood and fecal samples were collected weekly, and calves were weaned at 7 weeks of age. A TRT ×

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Che Alhadi, Shahidah, Wan Zainira Wan Zain, Zalina Zahari, et al. "The Use of M2-Pyruvate Kinase as a Stool Biomarker for Detection of Colorectal Cancer in Tertiary Teaching Hospital: A Comparative Study." Annals of Coloproctology 36, no. 6 (2020): 409–14. http://dx.doi.org/10.3393/ac.2020.08.27.

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Purpose: Guaiac fecal occult blood test (gFOBT) has been the standard for colorectal screening but it has low sensitivity and specificity. This study evaluated the use of fecal tumor M2-pyruvate kinase (M2-PK) for detection of colorectal cancer and to compare with the current surveillance tool; gFOBT in symptomatic adult subjects underwent colonoscopy.Methods: Stool samples were collected prospectively from symptomatic adults who had elective colonoscopy from September 2014 to January 2016 and were analyzed with the ScheBo M2-PK Quick test and laboratory detection of fecal hemoglobin.Results:

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Greuter, Marjolein JE, Beatriz Carvalho, Meike de Wit, et al. "Can a biomarker triage test reduce colonoscopy burden in fecal immunochemical test screening?" Journal of Comparative Effectiveness Research 9, no. 8 (2020): 563–71. http://dx.doi.org/10.2217/cer-2019-0130.

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Aim: To assess the potential of biomarker triage testing (BM-TT) in the Dutch colorectal cancer (CRC) screening program. Materials & methods: Using the Adenoma and Serrated pathway to Colorectal CAncer model, we simulated fecal immunochemical test (FIT)47-screening and various FIT plus BM-TT screening scenarios in which only individuals with both a positive FIT and BM-TT are referred to colonoscopy. Results: Adding a low polyp sensitivity BM-TT to FIT-screening reduced colonoscopy burden (89–100%) while increasing CRC mortality (27–41%) compared with FIT47-screening only. The FIT plus high

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Langhorst, Jost, James H. Boone, Andreas Rueffer, and Gustav J. Dobos. "M1238 Fecal Lactoferrin as Biomarker for Mucosal Healing in Patients With Ulcerative Colitis." Gastroenterology 138, no. 5 (2010): S—361. http://dx.doi.org/10.1016/s0016-5085(10)61664-2.

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Colman, Ruben, and David Rubin. "Fecal Alpha 1-Antitrypsin as a Biomarker for Disease Activity in Ulcerative Colitis." American Journal of Gastroenterology 109 (October 2014): S434. http://dx.doi.org/10.14309/00000434-201410002-01468.

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Kim, Duk Hwan, Yehyun Park, Bun Kim, et al. "Fecal calprotectin as a non-invasive biomarker for intestinal involvement of Behçet's disease." Journal of Gastroenterology and Hepatology 32, no. 3 (2017): 595–601. http://dx.doi.org/10.1111/jgh.13530.

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Galipeau, H. J., A. CAMINERO FERNANDEZ, W. Turpin, et al. "A29 NOVEL FECAL BIOMARKERS THAT PRECEDE CLINICAL DIAGNOSIS OF ULCERATIVE COLITIS." Journal of the Canadian Association of Gastroenterology 4, Supplement_1 (2021): 268–69. http://dx.doi.org/10.1093/jcag/gwab002.028.

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Abstract Background Altered gut microbiota composition and function has been associated with inflammatory bowel diseases (IBD) including ulcerative colitis (UC), but causality and mechanisms remain unknown. Most studies have examined patients with active or treated disease and little is known about microbial compositional or functional changes that occur before disease onset. Aims We studied a longitudinal cohort of subjects at risk for IBD to define the fecal microbial composition and function in subjects prior to UC onset (pre-UC) and at diagnosis (post-UC), and in matched at-risk subjects t

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