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1

Longobardi, G. P. "Fed-batch versus batch fermentation." Bioprocess Engineering 10, no. 5-6 (1994): 185–94. http://dx.doi.org/10.1007/bf00369529.

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2

Longobardi, G. P. "Fed-batch versus batch fermentation." Bioprocess Engineering 10, no. 5 (1994): 185. http://dx.doi.org/10.1007/s004490050043.

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3

Hadiyanto, H., D. Ariyanti, A. P. Aini, and D. S. Pinundi. "Batch and Fed-Batch Fermentation System on Ethanol Production from Whey using Kluyveromyces marxianus." International Journal of Renewable Energy Development 2, no. 3 (2013): 127–31. http://dx.doi.org/10.14710/ijred.2.3.127-131.

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Nowadays reserve of fossil fuel has gradually depleted. This condition forces many researchers to find energy alternatives which is renewable and sustainable in the future. Ethanol derived from cheese industrial waste (whey) using fermentation process can be a new perspective in order to secure both energy and environment. The aim of this study was to compare the operation modes (batch and fed-batch) of fermentation system on ethanol production from whey using Kluyveromyces marxianus. The result showed that the fermentation process for ethanol production by fed-batch system was higher at some
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4

Belo, I., and M. Mota. "Batch and fed-batch cultures of." Bioprocess Engineering 18, no. 6 (1998): 451. http://dx.doi.org/10.1007/s004490050470.

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5

Minihane, B. J., and D. E. Brown. "Fed-batch culture technology." Biotechnology Advances 4, no. 2 (1986): 207–18. http://dx.doi.org/10.1016/0734-9750(86)90309-5.

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6

Ramírez, Nicolás, Claudia Ubilla, Javiera Campos, et al. "Enzymatic production of lactulose by fed-batch and repeated fed-batch reactor." Bioresource Technology 341 (December 2021): 125769. http://dx.doi.org/10.1016/j.biortech.2021.125769.

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7

Upadhyay, Devang, Rinu Kooliyottil, Sivanadane Mandjiny, Floyd L. Inman III, and Leonard D. Holmes. "Mass Production of the Beneficial Nematode Steinernema carpocapsae Utilizing a Fed-Batch Culturing Process." International Journal of Phytopathology 2, no. 1 (2013): 52–58. http://dx.doi.org/10.33687/phytopath.002.01.0076.

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The present study deals with the batch and fed-batch mass production of Steinernema carpocapsae. S. carpocapsae is an entomoparasitic nematode that is used as a biological control agent of soil-borne crop insect pests. The ability and efficiency of fed-batch culture process was successful through the utilization of the nematode’s bacterial symbiont Xenorhabdus nematophila. Results from the fed-batch process were compared to those obtain from the standard batch process. The fed-batch process successively improved the mass production process of S. carpocapsae employing liquid medium technology.
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8

PAIK, HYUN-DONG, and BONITA A. GLATZ. "Enhanced Bacteriocin Production by Propionibacterium thoenii in Fed-Batch Fermentation‡." Journal of Food Protection 60, no. 12 (1997): 1529–33. http://dx.doi.org/10.4315/0362-028x-60.12.1529.

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Synthesis of the bacteriocin propionicin PLG-1 as well as culture growth and organic acid production by Propionibacterium thaenii P127 were followed in fed-batch fermentations conducted for 504 h in a sodium lactate broth. Average concentrations of viable cells were higher in two small-scale fed-batch fermentations than in batch fermentations: 2.2 × 109 cells per ml versus 3.7 × 108 cells per ml. Propionic acid concentration averaged 35.8 g/liter at the end of fed-batch fementation, and maximum bacteriocin titers were 184 and 146 AU/ml in the two fed-batch fermentations. After reaching the max
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9

Lee, Jeongseok, Sang Yup Lee, Sunwon Park, and Anton P. J. Middelberg. "Control of fed-batch fermentations." Biotechnology Advances 17, no. 1 (1999): 29–48. http://dx.doi.org/10.1016/s0734-9750(98)00015-9.

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10

Gregersen, Lars, and Sten Bay Jørgensen. "Supervision of fed-batch fermentations." Chemical Engineering Journal 75, no. 1 (1999): 69–76. http://dx.doi.org/10.1016/s1385-8947(99)00018-2.

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11

Gregersen, Lars, Sten Bay Jørgensen, and Maria Yolanda Andersen. "Industrial Fed-Batch Fermentation Monitoring." IFAC Proceedings Volumes 30, no. 9 (1997): 49–54. http://dx.doi.org/10.1016/s1474-6670(17)43138-7.

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12

Narihiro, Takashi, and Akira Hiraishi. "Microbiology of Fed-batch Composting." Microbes and Environments 20, no. 1 (2005): 1–13. http://dx.doi.org/10.1264/jsme2.20.1.

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13

Yang, Fan-Chiang, and Der-Wei Maa. "Fed-batch culture of yeast." Bioprocess Engineering 18, no. 2 (1998): 79. http://dx.doi.org/10.1007/s004490050415.

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14

Deng, Haixia, Meiyu Wang, and Erhu Li. "Continuous fed-batch strategy decreases acetic acid production and increases volatile ester formation in wines under high-gravity fermentation." OENO One 57, no. 1 (2023): 363–74. http://dx.doi.org/10.20870/oeno-one.2023.57.1.7238.

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High sugar fermentation elevates acetic acid levels in wines, which can be avoided by applying the continuous fed-batch strategy. In this study, yeast gene expressions and wine volatile compounds were evaluated by quantitative real-time PCR (RT-qPCR) and gas chromatograph mass spectrometry (GC-MS) in high-gravity (HG, 320 g/L sugars) fermentations with different batch strategies. The acetic acid concentration in continuous fed-batch fermentation wine was reduced by 51.69 %, compared with that in whole-batch fermentation wine. The acetyl-CoA synthase gene (ACS2) expression was up-regulated, whe
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15

Barnali, Mandal, and Chakraborty Aditia. "Pediocin production by Pediococcus acidilactici in fed batch fermentation using meat processing waste." Journal of Indian Chemical Society Vol. 97, Jun 2020 (2020): 903–9. https://doi.org/10.5281/zenodo.5664273.

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Department of Chemical Engineering, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata-700 009, India <em>E-mail:</em> bmandal20@yahoo.co.in <em>Manuscript received online 12 January 2020, revised and accepted 22 May 2020</em> Pediocin production by <em>Pediococcus acidilactici</em> was studied in a bio-reactor under two fed batch fermentations (fed batch operation I and fed batch operation II) at constant pH condition using meat processing waste. In fed batch operation II, higher pediocin activity of 4572 AU/ml was achieved comparing to fed batch operation I (pediocin activity
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16

Qu, Liang, Lu-Jing Ren, Guan-Nan Sun, Xiao-Jun Ji, Zhi-Kui Nie, and He Huang. "Batch, fed-batch and repeated fed-batch fermentation processes of the marine thraustochytrid Schizochytrium sp. for producing docosahexaenoic acid." Bioprocess and Biosystems Engineering 36, no. 12 (2013): 1905–12. http://dx.doi.org/10.1007/s00449-013-0966-7.

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17

Mendes, Sarah, Maria C. P. Gonçalves, Vitoria A. P. Aiex, et al. "Comparison Between Simple Batch and Fed-Batch Bioreactor Cultivation of Recombinant BCG." Pharmaceutics 16, no. 11 (2024): 1433. http://dx.doi.org/10.3390/pharmaceutics16111433.

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Background/Objectives: Tuberculosis continues to be a significant global health concern, causing 1.3 million deaths in 2022, particularly affecting children under 5 years old. The Bacillus Calmette-Guérin (BCG) vaccine, developed in 1921, remains the primary defense against tuberculosis but requires modernized production methods. The recombinant BCG-pertussis strain shows potential in providing dual protection against tuberculosis and whooping cough, especially for vulnerable newborns, and enhanced efficacy against bladder cancer. Implementing submerged cultivation techniques for rBCG-pertussi
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18

Furuichi, Keisuke, Yoshio Katakura, Kazuaki Ninomiya, and Suteaki Shioya. "Enhancement of 1,4-Dihydroxy-2-Naphthoic Acid Production by Propionibacterium freudenreichii ET-3 Fed-Batch Culture." Applied and Environmental Microbiology 73, no. 10 (2007): 3137–43. http://dx.doi.org/10.1128/aem.01307-06.

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ABSTRACT The production of 1,4-dihydroxy-2-naphthoic acid (DHNA) was investigated using a fed-batch culture of Propionibacterium freudenreichii ET-3. DHNA is a precursor of menaquinone (MK) and is transformed to MK by combination with an isoprenoid unit. We found that ET-3 stopped MK production and increased DHNA production in an anaerobic fed-batch culture by maintaining the lactose concentration at approximately zero. The maximum DHNA concentration observed in the anaerobic fed-batch culture was markedly higher than the maximum DHNA concentration observed in an anaerobic batch culture. Moreo
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19

Moriel, Danilo Gomes, Miriam Blumel Chociai, Iara Maria Pereira Machado, José Domingos Fontana, and Tania Maria Bordin Bonfim. "Effect of feeding methods on the astaxanthin production by Phaffia rhodozyma in fed-batch process." Brazilian Archives of Biology and Technology 48, no. 3 (2005): 397–401. http://dx.doi.org/10.1590/s1516-89132005000300010.

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The effect of feeding methods on the production of astaxanthin by the yeast Phaffia rhodozyma ATCC 24202 was studied, using continuous and pulsed fed-batch processes and low cost materials as substrates (sugar cane juice and urea). In continuous fed-batch processes, a cellular astaxanthin concentration of 383.73 µg/g biomass was obtained. But in pulsed fed-batch processes a reduction in the cellular astaxanthin concentration (303.34 µg/g biomass) was observed. Thus the continuous fed-batch processes could be an alternative to industrial production of astaxanthin, allowing an increase in the bi
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20

Mahé, Amélie, Alexandra Martiné, Séverine Fagète, and Pierre-Alain Girod. "Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production." Bioprocess and Biosystems Engineering 45, no. 2 (2021): 297–307. http://dx.doi.org/10.1007/s00449-021-02657-w.

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AbstractIn the field of therapeutic antibody production, diversification of fed-batch strategies is flourishing in response to the market demand. All manufacturing approaches tend to follow the generally accepted dogma of increasing titer since it directly increases manufacturing output. While titer is influenced by the biomass (expressed as IVCD), the culture time and the cell-specific productivity (qP), we changed independently each of these parameters to tune our process strategy towards adapted solutions to individual manufacturing needs. To do so, we worked separately on the increase of t
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21

Orra, A. A., S. M. Ratusznei, J. A. D. Rodrigues, E. Foresti, and M. Zaiat. "Effects of feeding strategies on the performance of an anaerobic discontinuous reactor containing immobilized biomass with circulation system for liquid-phase mixing." Water Science and Technology 49, no. 11-12 (2004): 303–10. http://dx.doi.org/10.2166/wst.2004.0867.

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Data on the influence of feeding strategy on the performance of a fed-batch anaerobic sequencing reactor containing biomass immobilized on polyurethane foam and subjected to liquid phase circulation are presented and discussed. Six-hour cycles, temperature of 30°C and circulation flow rate of 6 L/h were used. During each cycle 890 mL of synthetic domestic wastewater, with organic matter concentration of 500 mgCOD/L were fed to the reactor. The feeding strategies were implemented using fill times of 6 min (batch mode), 60, 120, 240 (fed-batch/batch mode) and 360 min (fed-batch mode). The system
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22

Balboa, Cristian, Rodrigo A. Schrebler, María Elena Lienqueo, and Nadia Guajardo. "Effect of Operational Variables on the Yield of Chemoenzymatic Oxidation of 2,5-Furandicarboxaldehyde to 2,5-Furandicarboxylic Acid in Fed-Batch and Continuous Packed-Bed Millibioreactor." Processes 10, no. 10 (2022): 2095. http://dx.doi.org/10.3390/pr10102095.

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This work explores for the first time the use of a fed-batch and continuous packed-bed millibioreactor for the chemoenzymatic oxidation of 2,5-furandicarboxaldehyde (DFF) to 2,5-furandicarboxylic acid (FDCA). Different operational variables were studied: temperature, substrate concentration, and flow rate using different reactors (batch, fed-batch, and a continuous packed-bed bioreactor). The best yield (100%) was achieved using the fed-batch reactor at an H2O2 flow rate of 3 µL/min with a substrate concentration (DFF) of 100 mM. Regarding the specific productivity, the highest values (&gt;0.0
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23

Sahinkaya, Erkan, and Filiz B. Dilek. "AEROBIC CHLOROPHENOL TREATMENT USING FED-BATCH AND SEQUENCING BATCH REACTORS." Proceedings of the Water Environment Federation 2002, no. 15 (2002): 349–62. http://dx.doi.org/10.2175/193864702784247783.

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24

He, Guo-qing, Qing Kong, Qi-he Chen, and Hui Ruan. "Batch and fed-batch production of butyric acid byClostridium butyricumZJUCB." Journal of Zhejiang University SCIENCE 6B, no. 11 (2005): 1076–80. http://dx.doi.org/10.1631/jzus.2005.b1076.

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25

Chen, Hung‐Chang. "Citric acid production byAspergillus foetidusin batch and fed‐batch cultures." Food Biotechnology 7, no. 3 (1993): 221–34. http://dx.doi.org/10.1080/08905439309549859.

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26

Bezerra, Raquel P., Marcelo C. Matsudo, Lina S. Pérez Mora, Sunao Sato, and João C. Monteiro de Carvalho. "Ethanol effect on batch and fed-batch Arthrospira platensis growth." Journal of Industrial Microbiology & Biotechnology 41, no. 4 (2014): 687–92. http://dx.doi.org/10.1007/s10295-014-1404-9.

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27

Duff, Sheldon J. B. "Use of surface-immobilizedTrichoderma in batch and fed-batch fermentations." Biotechnology and Bioengineering 31, no. 4 (1988): 345–48. http://dx.doi.org/10.1002/bit.260310410.

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28

Bayen, T., F. Mairet, and M. Mazade. "Fed-batch bioreactor with mortality rate." IFAC Proceedings Volumes 46, no. 23 (2013): 158–63. http://dx.doi.org/10.3182/20130904-3-fr-2041.00024.

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29

Nuhu, S. M. "FED-BATCH FERMENTATION FOR BIOETHANOL PRODUCTION." Young Scholars Journal, no. 2-3 (2021): 7–13. http://dx.doi.org/10.29013/ysj-21-2.3-7-13.

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30

Bonde, Durgesh, and Dr Satish Inamdar. "Optimal Control of fed batch bioreactor." International Journal of Research in Advent Technology 9, no. 5 (2021): 1–5. http://dx.doi.org/10.32622/ijrat.94202104.

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In this paper, we will consider the problem of optimal control of a fed batch reactor. Our objective is to simulate the fed batch reactor under specified conditions in order to find an optimal control policy. Thus, for any specified initial conditions and parameter values the optimal policy for reactor operation can be obtained from simulation. We have an example system of nosiheptide [1] and used gradient method to find optimal policy. Although the convergence is slow, an optimal solution is obtained and various plots are prepared that illustrate the applicability of the method well.
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31

Johnson, A. "Optimization of Fed-batch Biotechnical Processes." IFAC Proceedings Volumes 25, no. 2 (1992): 243–46. http://dx.doi.org/10.1016/s1474-6670(17)50362-6.

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32

Gao, Hua, and Tianwei Tan. "Fed-batch fermentation for ergosterol production." Process Biochemistry 39, no. 3 (2003): 345–50. http://dx.doi.org/10.1016/s0032-9592(03)00076-1.

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33

Kubičkova, Z., M. Kubiček, and M. Marek. "Fed-batch operation of stirred reactors." Chemical Engineering Science 42, no. 2 (1987): 327–33. http://dx.doi.org/10.1016/0009-2509(87)85062-5.

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34

Gray, P. P., and K. Vu-Trong. "Extended cyclic fed-batch tylosin fermentations." Biotechnology Letters 9, no. 9 (1987): 617–20. http://dx.doi.org/10.1007/bf01033197.

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35

Kuhlmann, C., I. D. L. Bogle, and Z. S. Chalabi. "Robust operation of fed batch fermenters." Bioprocess Engineering 19, no. 1 (1998): 53. http://dx.doi.org/10.1007/s004490050482.

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36

Kim, H. S., J. Y. Ju, J. H. Suh, and C. S. Shin. "Optimized fed-batch fermentation of L-." Bioprocess Engineering 20, no. 3 (1999): 189. http://dx.doi.org/10.1007/s004490050580.

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37

Randolph, T. W., I. W. Marison, D. E. Martens, and U. von Stockar. "Calorimetric control of fed-batch fermentations." Biotechnology and Bioengineering 36, no. 7 (1990): 678–84. http://dx.doi.org/10.1002/bit.260360705.

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38

Modak, J. M., and H. C. Lim. "Feedback optimization of fed-batch fermentation." Biotechnology and Bioengineering 30, no. 4 (1987): 528–40. http://dx.doi.org/10.1002/bit.260300410.

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39

Patwardhan, Pallavi, and Ashok K. Srivastava. "Fed-batch cultivation of Wautersia eutropha." Bioresource Technology 99, no. 6 (2008): 1787–92. http://dx.doi.org/10.1016/j.biortech.2007.03.034.

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40

Adnan, Azila, Giridhar Nair, Mark Lay, and Janis Swan. "Bacterial Cellulose Synthesis by Gluconacetobacter xylinus: Enhancement via Fed-batch Fermentation Strategies in Glycerol Media." Trends in Sciences 18, no. 22 (2021): 453. http://dx.doi.org/10.48048/tis.2021.453.

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Bacterial cellulose (BC) is an abundant polysaccharide, which is secreted by several genera of bacteria. It has remarkable characteristics, which include high purity, high tensile strength, high biocompatibility and non-toxic. The main feature that differentiates BC and plant cellulose (PC) is the absence of contaminants such as lignin, hemicellulose and pectin. However, the main drawbacks in producing BC are low yield and expensive carbon source. Due to that, this study was carried out to enhance BC volumetric productivity in fed-batch operation mode using glycerol as a carbon source. BC was
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41

Moore, Alex, and Jie Zhang. "Batch-to-Batch Optimization Control of Fed-Batch Fermentation Process Based on Recursively Updated Extreme Learning Machine Models." Algorithms 18, no. 2 (2025): 87. https://doi.org/10.3390/a18020087.

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This paper presents a new method of batch-to-batch optimization control for a fed-batch fermentation process. A recursively updated extreme learning machine (ELM) neural network model is used to model a fed-batch fermentation process. ELM models have advantages over other neural networks in that they can be trained very fast and have good generalization performance. However, the ELM model loses its predictive abilities in the presence of batch-to-batch process variations or disturbances, which lead to a process–model mismatch. The recursive least squares (RLS) technique takes the model predict
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42

Thongruck, Kanokwan, and Suppasil Maneerat. "Reusable Immobilized Lactobacillus futsaii CS3 for Enhanced GABA Synthesis using Low-Cost Substrates in Fermenter-Scale Batch and Fed-Batch Fermentations." Trends in Sciences 21, no. 12 (2024): 8514. http://dx.doi.org/10.48048/tis.2024.8514.

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On the industrial scale, the cost of commercial culture media for the production of gamma-aminobutyric acid (GABA) is a very important factor. This study employed a low-cost substrates and by-product from agri-food industry for GABA synthesis by Lact. futsaii CS3 at the fermenter-scale. Lact. futsaii CS3 cells were immobilized in 3 % (w/v) sodium alginate and employed for GABA synthesis in the optimal modified MRS medium (3.48 % (w/v) cane sugar, 3.84 % (w/v) tuna condensate waste and 10.77 % (w/v) monosodium glutamate (MSG)) with the initial pH medium of 5, fermentation temperature at 37 °C a
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43

Chua, Gek Kee, Soo Yang Kae, and Soo Yang Kae. "Development of Fed-Batch Strategy to Produce Bacteria Cellulose." ASM Science Journal 18 (December 29, 2023): 1–14. http://dx.doi.org/10.32802/asmscj.2023.1473.

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Bacteria Cellulose (BC) is a type of biopolymer widely used in areas such as biomedicine and paper manufacturing industries. The batch fermentation mode of BC is less cost-effective as the yield is low. This study aims to determine the best fed-batch cultivation strategy to produce BC of high yield and quality. First, batch fermentation mode was carried out to determine the glucose consumption profile of Gluconacetobacter xylinus using Yeast Extract Glucose Chloramphenicol Medium (YGC). By using the information, the fed-batch strategies with feeding frequencies of 1 time and 3 times per 14-day
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44

Xiong, Zhihua, Yixin Xu, Jie Zhang, and Jin Dong. "Batch-to-batch control of fed-batch processes using control-affine feedforward neural network." Neural Computing and Applications 17, no. 4 (2007): 425–32. http://dx.doi.org/10.1007/s00521-007-0142-6.

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45

Argo, Ellen, and Deepak R. Keshwani. "Techno-Economic Implications of Fed-Batch Enzymatic Hydrolysis." Processes 7, no. 11 (2019): 847. http://dx.doi.org/10.3390/pr7110847.

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Fed-batch enzymatic hydrolysis has the potential to improve the overall process of converting cellulosic biomass into ethanol. This paper utilizes a process simulation approach to identify and quantify techno-economic differences between batch and fed-batch enzymatic hydrolysis in cellulosic ethanol production. The entire process of converting corn stover into ethanol was simulated using SuperPro Designer simulation software. The analysis was conducted for a plant capacity of 2000 metric tons of dry biomass per day. A literature review was used to identify baseline parameters for the process.
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46

Béda Nestor KIMOU, Sonan Romuald ASSI, Awa TRAORÉ, and Boua Célestin ATSE. "Effect of the combination of two types of fish feed with nutritional quality on the performance of two species of fish raised on rural and peri-urban farms in Cote D'ivoire." World Journal of Advanced Research and Reviews 24, no. 1 (2024): 641–47. http://dx.doi.org/10.30574/wjarr.2024.24.1.3000.

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For 160 days, juvenile Oreochromis niloticus and Heterobranchus longifilis were in ponds on a farm in San Perdo located in the southwest of Côte d’Ivoire.The juveniles grouped in four lot per species and in triplicate were fed in pairs of industrial feed and feed produced on the farm and an agri-feed by-product from four feeding techniques (Batch 1: juveniles fed with an industrial lime in the pre-growing phase followed by an agricultural by-product in the growing phase. Batch 2: Juveniles fed with an industrial feed then a feed formulated with an agricultural product during the growing phase
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47

Shen, Chun Fang, Anja Rodenbrock, Stephane Lanthier, Elodie Burney, and Martin Loignon. "Optimization of Culture Media and Feeding Strategy for High Titer Production of an Adenoviral Vector in HEK 293 Fed-Batch Culture." Vaccines 12, no. 5 (2024): 524. http://dx.doi.org/10.3390/vaccines12050524.

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Adenoviruses are efficient and safe vectors for delivering target antigens and adenovirus-based vaccines have been used against a wide variety of pathogens, including tuberculosis and COVID-19. Cost-effective and scalable biomanufacturing processes are critical for the commercialization of adenovirus-vectored vaccines. Adenoviral vectors are commonly produced through the infection of batch cultures at low cell density cultures, mostly because infections at high cell densities result in reduced cell-specific virus productivity and does not improve volumetric productivity. In this study, we have
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48

Ammar, Yessin, Patrick Cognet, and Michel Cabassud. "ANN for hybrid modelling of batch and fed-batch chemical reactors." Chemical Engineering Science 237 (June 2021): 116522. http://dx.doi.org/10.1016/j.ces.2021.116522.

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49

Dorka, Penny, Christian Fischer, Hector M. Budman, and Jeno M. Scharer. "MODEL FORMULATION FOR HYBRIDOMA CULTURES IN BATCH AND FED-BATCH MODE." IFAC Proceedings Volumes 40, no. 4 (2007): 181–86. http://dx.doi.org/10.3182/20070604-3-mx-2914.00032.

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50

Binaghi, L., A. Del Borghi, A. Lodi, A. Converti, and M. Del Borghi. "Batch and fed-batch uptake of carbon dioxide by Spirulina platensis." Process Biochemistry 38, no. 9 (2003): 1341–46. http://dx.doi.org/10.1016/s0032-9592(03)00003-7.

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