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Journal articles on the topic 'Ferrous ascorbate'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Manju Toppo, Jeewan S. Meena, Devendra Gour, et al. "A Community-Based Trial on The Comparison of Efficacy, Safety and Cost Effectiveness of Ferrous Sulphate and Ferrous Ascorbate for Anaemia in Pregnancy In Madhya Pradesh, India." National Journal of Community Medicine 14, no. 02 (2023): 74–81. http://dx.doi.org/10.55489/njcm.140220232583.

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Background: Anaemia has significant impact on health of the fetus as well as that of mother. Increased need of iron during pregnancy especially after 2nd trimester makes iron supplementation mandatory. Ferrous ascorbate is known to exist intact inside the gastrointestinal tract due to the stable chelation of iron with ascorbate. This compound does not dissociate due to any of the food inhibitors. The aim is to study the effectiveness of Ferrous Ascorbate and Ferrous sulphate in terms of compliance and cost effectiveness of management of anaemia in pregnancy. Methodology: Study design: Quasi Ex

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Ritvija, Dixit, Mittal Adreena, Singhal Parul, and Dey Saborni. "Evaluation of the Effect of Iron Sucrose and Ferrous Ascorbate for the Treatment of Anaemia during Pregnancy: A Randomised Controlled Trial." International Journal of Pharmaceutical and Clinical Research 15, no. 7 (2023): 409–14. https://doi.org/10.5281/zenodo.11641134.

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<strong>Background:</strong> Anaemia during pregnancy is a prevalent condition associated with adverse maternal and fetal outcomes. Traditional oral iron supplementation often faces challenges in terms of efficacy, tolerability, and compliance. This study aimed to evaluate the effectiveness of alternative iron formulations, iron sucrose and ferrous ascorbate, in treating anaemia during pregnancy through a randomized controlled trial. <strong>Methods:</strong> A total of 400 pregnant women with anaemia were randomized into four treatment groups: iron sucrose, ferrous ascorbate, t

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Asati, Diksha, Arvind Kumar Yadav, and Sanjay Mandot. "Comparison between oral ferrous ascorbate and colloidal iron in the treatment of iron deficiency anemia." International Journal of Contemporary Pediatrics 8, no. 4 (2021): 694. http://dx.doi.org/10.18203/2349-3291.ijcp20211079.

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Background: Anemia is a global health issue. There is association of impaired cognition and iron deficiency anemia. Ferrous and ferric forms of oral iron preparations are available for the treatment of iron deficiency anemia. This study was conducted with an aim to compare the efficacy and safety of oral ferrous ascorbate and colloidal iron in the treatment of iron deficiency anemia.Methods: It was a prospective interventional study with 12 weeks of treatment protocols alternatively assigned to children diagnosed with iron deficiency anemia. Patients received either of two iron preparation use

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Sowjanya, Mudigonda, Nishad, Fariya, Malla Rajeshwari, and Dr K. Lakshmi Surekha. "A Comparative Study of Ferrous Ascorbate and Ferrous Fumarate in Treating Iron Deficiency Anaemia during Pregnancy: Efficacy and Safety analysis." International Journal of Research in Pharmacy and Allied Science 04, no. 02 (2025): 01–12. https://doi.org/10.71431/ijrpas.2025.4204.

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Introduction: Iron deficiency anaemia is the most common type of anaemia in pregnant women. Due to extra demands during pregnancy, they are more susceptible to anaemia. The demand of iron is generally low in the first trimester and high in the third trimester. In India 90% of anaemia’s are caused due to iron deficiency. Aim and Objectives: To compare the safety and efficacy of ferrous ascorbate and ferrous fumarate in the treatment of iron deficiency anaemia in pregnant women and to and to assess its cost effectiveness ratio. Materials and Methodology: About 118 subjects were included in the s

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Kiran, L. J. "Comparative evaluation of efficacy of ferrous ascorbate and ferrous calcium citrate prepared in multidrug delivery system on haemoglobin status in anaemic pregnant women." International Journal of Preclinical and Clinical Research 1, no. 1 (2020): 7–11. http://dx.doi.org/10.51131/ijpccr/v1i1.3.

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Iron deficiency anaemia (IDA), the most prevalent nutritional deficiency leading to mortality globally. Oral ferrous salts are effectively used to treat iron deficiency in pregnancy. For the present study, no direct comparison demonstrating the efficacy of ferrous ascorbate and ferrous calcium citrate was considered. An open-label, observational study was designed and conducted for two months. Subjects were randomly allocated to two groups (Group A and Group B). The medication followed in Group A was, ferrous calcium citrate with elemental iron 50 mg; In Group B ferrous ascorbate containing el

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Govindaraju, S. L. Manojna, Padmasri Yalamanchili, Kesava Lakshmi Prasad Kandipudi, and Sarada Vadlamani. "Comparison of the effectiveness of ferrous ascorbate with ferrous sulphate in improving haemoglobin percentage among ante-natal mothers in rural field practice area of a medical college." Journal of Family Medicine and Primary Care 13, no. 10 (2024): 4225–30. http://dx.doi.org/10.4103/jfmpc.jfmpc_201_24.

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ABSTRACT Background: Anaemia in pregnancy is defined by the World Health Organisation (WHO) as a haemoglobin concentration of less than 11 g/dl in venous blood. The prevalence of anaemia among ante-natal mothers in India is 50.3%[3]. The government of India supplies ferrous sulphate for prophylaxis and treatment of anaemia among ante-natal mothers for free through the reproductive maternal neonatal and child health + adolescent (RMNCH+A) programme. However, patient compliance is poor due to gastrointestinal disturbances (of all registered pregnancies, less than 1/3 consumed a full course of fe

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Kulkarni, Prashant, and Sasikumar Menon. "A randomized open-label study to compare iron content in the blood of healthy subjects treated with Tasiron tablets containing ferric di-phosphate as compared to tablets containing ferrous ascorbate." International Journal of Advances in Medicine 10, no. 12 (2023): 836–39. http://dx.doi.org/10.18203/2349-3933.ijam20233567.

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Iron deficiency anemia (IDA) frequently affects reproductive-age women, pregnant women, and children of growing age, particularly in developing countries like India. Traditional oral iron supplementation has various side effects, and therefore, liposomal technology has been introduced. This study compared serum iron levels in healthy adult female subjects treated with Tasiron tablets containing 30 mg (elemental iron) of micronized liposomal ferric di-phosphate, with those administered with tablets containing 100 mg (elemental iron) of ferrous ascorbate, over 15 days. The test group (n=7) recei

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Moumita, Hazra. "A Molecular Pharmacokinetic Study on the Comparative Pharmacological Response and Patient Adherence to Ferrous Ascorbate, Ferrous Sulphate, Ferrous Fumarate and Ferric Ammonium Citrate: An Analytical Evidence-Based Clinical Research." International Journal of Toxicological and Pharmacological Research 12, no. 3 (2022): 44–52. https://doi.org/10.5281/zenodo.12508727.

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<strong>Background: </strong>Anaemia is a global health concern, during adolescence, pregnancy and lactation, controlled by oral haematinics, like ferrous ascorbate, ferrous fumarate, ferrous sulphate and ferric ammonium citrate. <strong>Objectives: </strong>This analytical evidence-based clinical research was conducted for the molecular pharmacokinetic study on the comparative pharmacological response and patient adherence to ferrous ascorbate, ferrous sulphate, ferrous fumarate and ferric ammonium citrate, in tertiary patient healthcare hospitals. <strong>Materials and Me

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Milanovic, Svetlana, Miodrag Lazarevic, Zivan Jokic, Olivera Pesut, Danijela Kirovski, and Ivan Jovanovic. "The influence of organic and inorganic Fe supplementation on productivity of broilers." Veterinarski glasnik 61, no. 5-6 (2007): 279–89. http://dx.doi.org/10.2298/vetgl0706279m.

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The aim of this study was to investigate the influence of organic and inorganic Fe supplementation on productivity of broiler chickens. The trial was conducted on 200 Arbor Acres chickens divided into four equal groups. Birds from all groups were fed standard broiler feed, supplemented with 40 mg/kg of Fe originating from different sources: Group I (FeSO4), Group II (Fe bound to yeast), Group III (ferrous ascorbate) and Group IV (iron chelate). From each group, 10 birds were sacrificed on the 21st, 35th and 42nd day and the following parameters were measured: body mass, daily body mass gain, f

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Tamilselvan, T., Nissy Nelson Shanet, Ann Thomas Senorita, KM Shabla, and Sathyan Sneha. "Assessment of Efficacy and Cost-Effectiveness of Oral and IV Iron Therapy in Chronic Kidney Disease." Journal of Drug Delivery and Therapeutics 13, no. 11 (2023): 107–10. http://dx.doi.org/10.22270/jddt.v13i11.6306.

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Introduction: Long-term iron therapy for anemia in chronic kidney disease patients is creating an economic burden and discontinuation of the treatment. Objective: The purpose of this study was to assess the cost-effectiveness and efficacy of oral and intravenous iron therapy and iron therapy. Methods: the patients were distributed into group 1 and group 2 and were administered with oral and intravenous iron therapy respectively. Baseline hemoglobin and packed cell volume were recorded and subsequently monitored in the next follow-up visit to assess the efficacy of the iron therapy. Results: Am

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Divya, Sri Keerthika B. Priyanka B. P. Harith Mahesh Gomasa Dr. Swathi Boddupally*. "Study On Efficacy and Compliance of Oral Supplements with Ferric Pyrophosphate and Ferrous Ascorbate in Iron Deficiency Anaemia During Pregnancy." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1080–86. https://doi.org/10.5281/zenodo.15354355.

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Background: Iron deficiency anaemia in pregnancy is a nutritional disorder characterized by insufficient iron levels, leading to reduced haemoglobin production. This condition poses significant risks to both maternal and fatal health including increased chances of preterm birth, low birth, weight and maternal morbidity. It often results from inadequate dietary intake, poor iron absorption, or increased iron requirements during pregnancy. Early diagnosis and appropriate management through iron supplementation and dietary adjustments are crucial to mitigate adverse outcomes and promote healthy p

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Zhang, Z., C. J. Schofield, J. E. Baldwin, P. Thomas, and P. John. "Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli." Biochemical Journal 307, no. 1 (1995): 77–85. http://dx.doi.org/10.1042/bj3070077.

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1-Aminocyclopropane-1-carboxylate (ACC) oxidase catalyses the final step in the biosynthesis of the plant hormone ethylene. The successful overexpression and characterization of active ACC oxidase from tomato has been achieved. PCR was used to insert the corrected cDNA coding for the tomato ACC oxidase into the pET-11a expression vector. Cloning of the resultant construct in Escherichia coli BL21(DE3)pLysE gave transformants which expressed ACC oxidase at levels greater than 30% of soluble protein under optimized conditions. When induced by addition of isopropyl-beta-D-thiogalactopyranoside (I

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13

Magnusson, Bengt, Leif Hallberg, and Bertil Arvidsson. "IRON ABSORPTION FROM FOOD AND FROM FERROUS ASCORBATE." Scandinavian Journal of Haematology 17, S26 (2009): 69–85. http://dx.doi.org/10.1111/j.1600-0609.1976.tb01456.x.

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14

Hazra, Moumita. "A study on the aspects of pharmacoepidemiology and pharmacohaemovigilance of ferrous ascorbate, ferrous fumarate, ferrous sulphate and ferric ammonium citrate, among the rural anaemic women, in the Indian spectrum." International Journal of Basic & Clinical Pharmacology 8, no. 12 (2019): 2751. http://dx.doi.org/10.18203/2319-2003.ijbcp20195291.

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Background: Anaemia is a global health concern, associated with increased maternal and perinatal mortality, preterm delivery, low birth weight, extreme fatigue and impaired immune system; and controlled by oral haematinics; with a rise in haemoglobin concentration. The objective was to examine the various aspects of pharmacoepidemiology and pharmacohaemovigilance of oral haematinics, among the anaemic women population, in rural India.Methods: This was a multi-centre, retrospective, observational and analytical study of the hospital medical records of 250 anaemic patients, who were allocated in

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Suva, Manoj Arajanbhai, and Pravin Rambhai Tirgar. "Comparative evaluation of anti-anemic effect of Sucrosomial iron in experimental model of iron deficiency anemia in Wistar rats." Current Issues in Pharmacy and Medical Sciences 37, no. 1 (2024): 26–32. http://dx.doi.org/10.2478/cipms-2024-0005.

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Abstract Anemia is a grave public health issue that affects 25% of the global population. Conventional iron formulations used in treatment have drawbacks such as poor bioavailability and gastric intolerability. The current study aimed to evaluate the anti-anemic effects of different iron salts in Wistar rats with iron deficiency anemia (IDA). IDA was induced by the validated pre-clinical model by retro-orbital bloodletting (1 ml) for 21 days along with an iron-deficient diet in Wistar rats. The rats (n=48) were assigned into 8 groups: Control group, IDA rats, IDA rats receiving either vehicle

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16

Gutteridge, John M. C. "Ferrous ions detected in cerebrospinal fluid by using bleomycin and DNA damage." Clinical Science 82, no. 3 (1992): 315–20. http://dx.doi.org/10.1042/cs0820315.

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1. During pathological states of iron-overload or oxidant stress, low-molecular-mass iron can become available within extracellular fluids. 2. This iron would be converted to the ferrous state were it not for the protective anti-oxidant protein caeruloplasmin. 3. The ferrous-ion-oxidizing activity of caeruloplasmin rapidly converts ferrous ions back to the less reactive ferric state so that they can bind to available binding sites on transferrin. 4. Cerebrospinal fluids, however, often appear to contain low-molecular-mass iron, high levels of ascorbate and low levels of ferroxidase activity wi

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Lane, Darius J. R., Stephen R. Robinson, Hania Czerwinska, Glenda M. Bishop, and Alfons Lawen. "Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron." Biochemical Journal 432, no. 1 (2010): 123–32. http://dx.doi.org/10.1042/bj20101317.

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Astrocytes are central to iron and ascorbate homoeostasis within the brain. Although NTBI (non-transferrin-bound iron) may be a major form of iron imported by astrocytes in vivo, the mechanisms responsible remain unclear. The present study examines NTBI uptake by cultured astrocytes and the involvement of ascorbate and DMT1 (divalent metal transporter 1). We demonstrate that iron accumulation by ascorbate-deficient astrocytes is insensitive to both membrane-impermeant Fe(II) chelators and to the addition of the ferroxidase caeruloplasmin. However, when astrocytes are ascorbate-replete, as occu

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Moore, RB, TM Hulgan, JW Green, and LD Jenkins. "Increased susceptibility of the sickle cell membrane Ca2+ + Mg(2+)- ATPase to t-butylhydroperoxide: protective effects of ascorbate and desferal." Blood 79, no. 5 (1992): 1334–41. http://dx.doi.org/10.1182/blood.v79.5.1334.1334.

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Abstract Normal and sickle cell erythrocyte membranes were examined for significant differences in their ATPase activities, thiobarbituric acid reactive products formed (measured relative to malondialdehyde), membrane protein polymerization, and number of protein-free sulfhydryl groups when treated with 0.5 mmol/L t-butylhydroperoxide (tBHP) for 30 minutes. Isolated sickle cell membranes treated with tBHP produced significantly greater inhibition in both their basal and calmodulin- stimulated Ca2+ + Mg(2+)-ATPase activities (75% inhibition in both cases) compared with that of control membranes

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Moore, RB, TM Hulgan, JW Green, and LD Jenkins. "Increased susceptibility of the sickle cell membrane Ca2+ + Mg(2+)- ATPase to t-butylhydroperoxide: protective effects of ascorbate and desferal." Blood 79, no. 5 (1992): 1334–41. http://dx.doi.org/10.1182/blood.v79.5.1334.bloodjournal7951334.

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Normal and sickle cell erythrocyte membranes were examined for significant differences in their ATPase activities, thiobarbituric acid reactive products formed (measured relative to malondialdehyde), membrane protein polymerization, and number of protein-free sulfhydryl groups when treated with 0.5 mmol/L t-butylhydroperoxide (tBHP) for 30 minutes. Isolated sickle cell membranes treated with tBHP produced significantly greater inhibition in both their basal and calmodulin- stimulated Ca2+ + Mg(2+)-ATPase activities (75% inhibition in both cases) compared with that of control membranes. In addi

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Gutteridge, John M. C. "Plasma ascorbate levels and inhibition of the antioxidant activity of caeruloplasmin." Clinical Science 81, no. 3 (1991): 413–17. http://dx.doi.org/10.1042/cs0810413.

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1. The copper-containing protein caeruloplasmin has several oxidase activities. 2. Its ability to catalyse the oxidation of ferrous ions to the ferric state (ferroxidase activity) makes it an important antioxidant in vivo. 3. Recent reports have suggested that oral supplementation with vitamin C can inhibit the oxidase activities of caeruloplasmin. 4. As expected, damage to DNA and membrane lipids was stimulated by mixtures of iron salt and ascorbate, and this damage could be inhibited by caeruloplasmin provided the molar ratio of ascorbate to caeruloplasmin was kept sufficiently low. 5. When

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Mhaske, Ganesh, Preeti Vadehra, and Chandrakala Maran. "Compare the safety and efficacy of intravenous iron supplementation with iron sucrose to the oral supplementation with ferrous ascorbate in subjects with post-partum anemia." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 9 (2019): 3590. http://dx.doi.org/10.18203/2320-1770.ijrcog20193780.

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Background: The post-partum period is challenging enough for most new mothers. Recovering from birth, learning to parent, and taking care of her child requires lot of energy. Having anemia in postpartum period can make this process much more difficult. According to WHO, in India incidence of anemia in postnatal mother is around 58% and according to ICMR prevalence of anemia in Tamil Nadu population 76% during pregnancy. The objective of this study was to compare the efficacy of intravenous iron supplementation with Iron sucrose to the oral supplementation with ferrous ascorbate in management o

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LAWRENCE, Christopher C., Wendy J. SOBEY, Robert A. FIELD, Jack E. BALDWIN, and Christopher J. SCHOFIELD. "Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis." Biochemical Journal 313, no. 1 (1996): 185–91. http://dx.doi.org/10.1042/bj3130185.

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Proline 4-hydroxylase is a 2-oxoacid, ferrous-ion-dependent dioxygenase involved in the biosynthesis of the secondary metabolite etamycin. The purification, in low yield, of proline 4-hydroxylase from Streptomyces griseoviridus P8648 to near apparent homogeneity and its initial characterization are reported. In most respects proline 4-hydroxylase is a typical member of the 2-oxoacid-dependent dioxygenase family. It is monomeric (Mr approx. 38000) (by gel filtration on Superdex-G75) and has typically strict requirements for ferrous ion and 2-oxoglutarate. The enzyme was inhibited by aromatic an

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Kontoghiorghes, George J., Annita Kolnagou, Christina N. Kontoghiorghe, Loukia Mourouzidis, Viktor A. Timoshnikov, and Nikolay E. Polyakov. "Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications." Medicines 7, no. 8 (2020): 45. http://dx.doi.org/10.3390/medicines7080045.

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Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and development of humans, and their deficiency can result in serious diseases. Their interaction is of nutritional, physiological, pharmacological and toxicological interest, with major implications in health and disease. Millions of people are using pharmaceutical and nutraceutical preparations of these two nutrients, including ferrous ascorbate for the treatment of iron deficiency anaemia and ascorbate combination with deferoxamine for increasing iron excretion in iron overload. The main function and use of vit

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Kazi, Asma, Aisha Aziz, Shoaib Ahmed, Sabeena Umer, Shazia Roman, and Faiza Irshad. "Iron Supplementation in Anemic Pregnant Women: A Comparison of Different Prescription Options in Pakistan." Pakistan Journal of Medical and Health Sciences 16, no. 7 (2022): 342–43. http://dx.doi.org/10.53350/pjmhs22167342.

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Background & objectives: Many pregnant women in Pakistan have iron deficiency anemia (IDA), a dietary deficit. It affects both the mother's and the foetal' health. Oral iron supplementation usually relieves IDA symptoms. Oral iron supplements are hazardous to the GI mucosa, and sensitivity is common. Poor therapeutic compliance leads to treatment failure. Ferrous ascorbate (FeA) and iron hydroxide polymaltose complex (IPC) reportedly improve gastrointestinal discomfort and increase patient compliance compared to ferrous sulphate (FS). These preparations reportedly improve hemoglobin levels

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Jain, Yogesh K., Nitin K. Joshi, Kalpana R. Shah, Isha Chittora, and Vibha Joshi. "Intravenous verses oral iron supplementation for anaemia of pregnancy in the arid region of Western India: a retrospective cohort study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 11, no. 4 (2022): 1177. http://dx.doi.org/10.18203/2320-1770.ijrcog20220900.

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Background: India has a high prevalence of anemia in pregnant females, resulting greater risk of blood transfusion and its associated complications during the peripartum period. Administration of intravenous iron sucrose may reduce such a risk. Due to a greater prevalence in western arid region of India, this study was planned to compare efficacy and safety of intravenous iron sucrose and oral ferrous ascorbate in the treatment of iron deficiency anemia of pregnancy in a community health center of rural Jodhpur.Methods: A retrospective cohort study was conducted in Community Health Center of J

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BALL, BARRY A., and VO ANTHONY. "Detection of Lipid Peroxidation in Equine Spermatozoa Based Upon the Lipophilic Fluorescent Dye C₁₁‐BODIPY^581/591." Journal of Andrology 23, no. 2 (2002): 259–69. http://dx.doi.org/10.1002/j.1939-4640.2002.tb02623.x.

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ABSTRACT: The lipophilic fluorescent probe, 4,4‐difluoro‐5‐(4‐phenyl‐1,3‐butadienyl)‐4‐bora‐3a, 4a‐diaza‐s‐indacene‐3‐undecanoic acid (C11‐BODIPY581/591) was used to evaluate changes in lipid peroxidation in equine spermatozoa during both short‐term exposure to ferrous sulfate and sodium ascorbate in the presence of cumene hydroperoxide as well as during storage of spermatozoa at 5°C for 48 hours. Peroxidation of C11‐BODIPY581/591 was accompanied by a shift in fluorescence from red to green, and the relative amount of nonoxidized probe was determined as the ratio of red:(red + green) fluoresce

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Bates, Christopher J., Kerry S. Jones, and Leslie J. C. Bluck. "Stable isotope-labelled vitamin C as a probe for vitamin C absorption by human subjects." British Journal of Nutrition 91, no. 5 (2004): 699–705. http://dx.doi.org/10.1079/bjn20041103.

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Factors affecting absorption of physiological doses of vitamin C in man have not been widely studied, partly because few suitable tools exist to distinguish recently absorbed vitamin C from endogenous vitamin. Stable isotope-labelled vitamin C provides such a tool. Fifteen healthy non-smoking subjects aged 26–59 years were studied. Each received 30 mg L-[1-13C]ascorbic acid orally on two occasions, 3–4 weeks apart. The ascorbate was given alone or with Fe (100 mg as ferrous fumarate) or with red grape juice, which is rich in polyphenols. Blood was collected at frequent intervals for 1 h, and t

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Crake, R. L. I., E. R. Burgess, G. A. R. Wiggins, et al. "P12.06.A Relationship between ascorbate and DNA methylation markers in clinical glioma tumours." Neuro-Oncology 24, Supplement_2 (2022): ii78. http://dx.doi.org/10.1093/neuonc/noac174.271.

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Abstract Background Members of the 2-oxoglutarate-dependent dioxygenase (OGDD) enzyme family play an important role in gliomas as they regulate epigenetic modifications and response to hypoxia. The OGDDs require 2-OG and O2 as substrates, and ferrous iron and ascorbate as cofactors. Both hypoxia and aberrant DNA methylation are prognostic indicators for gliomas. The ten-eleven translocase (TET) DNA demethylases are OGDDs that convert 5-methyl cytosine (5mC) to 5-hydroxymethylcytosine (5hmC), with 5hmC levels related to better prognosis. Despite this, there is limited data on the OGDD enzymes a

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Atanasova, Bisera, Robert Simpson, Andy Li, Kamen Tzatchev, and Timothy Peters. "Duodenal mucosal and plasma ascorbate levels of patients with iron deficiency." Jugoslovenska medicinska biohemija 23, no. 3 (2004): 279–83. http://dx.doi.org/10.2298/jmh0403279a.

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Iron is a vital element for almost all living organisms. In mammals iron is taken by the intestinal epithelium, primarily in the duodenum. The initial step of absorption involves the reduction of ferric to ferrous iron both in gastric lumen and at the brush-border apical membrane. Reductase activity is increased by factors physiologically stimulating iron absorption, such as iron deficiency and chronic hypoxia. Ascorbic acid (Vitamin C) has long been known to enhance absorption of dietary iron in humans as shown by several nutritional/dietetic studies. This effect has been ascribed to lumenal

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Wyckoff, Elizabeth E., Alexandra R. Mey, Andreas Leimbach, Carolyn F. Fisher, and Shelley M. Payne. "Characterization of Ferric and Ferrous Iron Transport Systems in Vibrio cholerae." Journal of Bacteriology 188, no. 18 (2006): 6515–23. http://dx.doi.org/10.1128/jb.00626-06.

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ABSTRACT Vibrio cholerae has multiple iron acquisition systems, including TonB-dependent transport of heme and of the catechol siderophore vibriobactin. Strains defective in both of these systems grow well in laboratory media and in the infant mouse intestine, indicating the presence of additional iron acquisition systems. Previously uncharacterized potential iron transport systems, including a homologue of the ferrous transporter Feo and a periplasmic binding protein-dependent ATP binding cassette (ABC) transport system, termed Fbp, were identified in the V. cholerae genome sequence. Clones e

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Blinov, A. V., A. V. Samovolov, E. S. Kastarnova, E. D. Nazaretova, Z. A. Rehman, and M. B. Rebezov. "Iron nicotinatoascorbate: synthesis, toxicity, application prospects." Agrarian science, no. 3 (March 21, 2025): 137–43. https://doi.org/10.32634/0869-8155-2025-392-03-137-143.

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In this work, the effect of a triple chelate iron-containing complex on laboratory animals was investigated. To synthesize the triple chelate iron-containing complex, vitamin B3 was mixed with ascorbic acid in a molar ratio of 1:1. The synthesis was carried out by a mechanochemical method from a ferrous sulfate precursor. Quantum-chemical modeling of the interaction of iron with vitamins C and B3 was carried out using the QChem program. As a result, it was found that the optimal interaction is the iron atom with vitamin B3 through the carboxyl group and tertiary amino group in the pyridine rin

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Abosharaf, Hamed A., Yuki Sakamoto, Aliaa M. Radwan, et al. "Functional Assembly of Caenorhabditis elegans Cytochrome b-2 (Cecytb-2) into Phospholipid Bilayer Nanodisc with Enhanced Iron Reductase Activity." Biomolecules 11, no. 1 (2021): 96. http://dx.doi.org/10.3390/biom11010096.

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Among seven homologs of cytochrome b561 in a model organism C. elegans, Cecytb-2 was confirmed to be expressed in digestive organs and was considered as a homolog of human Dcytb functioning as a ferric reductase. Cecytb-2 protein was expressed in Pichia pastoris cells, purified, and reconstituted into a phospholipid bilayer nanodisc. The reconstituted Cecytb-2 in nanodisc environments was extremely stable and more reducible with ascorbate than in a detergent-micelle state. We confirmed the ferric reductase activity of Cecytb-2 by analyzing the oxidation of ferrous heme upon addition of ferric

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Singh, Kuldeep, Subheet K. Jain, Karan Razdan, et al. "Formulation and Evaluation of Ferrous Ascorbate Floating Tablets for the Treatment of Anaemia." Drug Delivery Letters 9, no. 4 (2019): 299–307. http://dx.doi.org/10.2174/2210303109666190708151137.

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Background and Objective: Ferrous ascorbate (FA) is preferentially absorbed from the upper gastrointestinal (GI) track, and has low bioavailability due to less residence time of FA in upper GI track. In addition, FA has low solubility and stability at higher pH. The aim of this study was to prepare gastro-retentive tablets of FA in order to increase its gastric residence time and hence, bioavailability. Methods: Floating tablets of FA were prepared by wet granulation method using different retarding polymers, Povidone K30 as binder and sodium bicarbonate as effervescent agent. The prepared flo

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Tvrdá, Eva, Anton Kováčik, Eva Tušimová, Peter Massányi, and Norbert Lukáč. "Resveratrol offers protection to oxidative stress induced by ferrous ascorbate in bovine spermatozoa." Journal of Environmental Science and Health, Part A 50, no. 14 (2015): 1440–51. http://dx.doi.org/10.1080/10934529.2015.1071153.

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Kriplani, Alka, Narendra Malhotra, Bhaskar Pal, Vidya Bhat, and Onkar Swami. "Ferrous Ascorbate: Current Clinical Place of Therapy in the Management of Iron Deficiency Anemia." Journal of South Asian Federation of Obstetrics and Gynaecology 13, no. 3 (2021): 103–9. http://dx.doi.org/10.5005/jp-journals-10006-1896.

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Saber, Mohamed, Mohamed Khalaf, Ahmed M. Abbas, and Sayed A. Abdullah. "Management of postpartum iron deficiency anemia: review of literature." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 1 (2018): 338. http://dx.doi.org/10.18203/2320-1770.ijrcog20185450.

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Anemia is a condition in which either the number of circulating red blood cells or their hemoglobin concentration is decreased. As a result, there is decreased transport of oxygen from the lungs to peripheral tissues. The standard approach to treatment of postpartum iron deficiency anemia is oral iron supplementation, with blood transfusion reserved for more server or symptomatic cases. There are a number of hazards of allogenic blood transfusion including transfusion of the wrong blood, infection, anaphylaxis and lung injury, any of which will be devastating for a young mother. These hazards,

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Rekha Kumari, Hariprasad Rao L, Gopinath T T, and Pandiyan K R. "Investigation on Haematinic accessible Assortments and Measurable Structures available in Indian Markets." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 704–8. http://dx.doi.org/10.26452/ijrps.v11ispl4.4022.

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To investigate Haematinic definitions accessible in India arcade for their assortments of measurements structures, hard salts utilized, the substance of essential iron, recurrence of organization compulsory, the occurrence of extra supplements, levelheadedness and price. Haematinic details recorded in IDR 2018, were investigated for salts of Iron present. Arrangements of ferrous fumarate were additionally investigated for Iron substance, presence of folic corrosive and other included extra parts. A sum of 522 plans, 291 (55.74%) was oral strong measurement structure, 206 (39.46%) were oral flu

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Rana, Proteesh, Suyash Chavan, Reva Tripathi, and Uma Tekur. "Comparison of efficacy & safety of iron polymaltose complex & ferrous ascorbate with ferrous sulphate in pregnant women with iron-deficiency anaemia." Indian Journal of Medical Research 154, no. 1 (2021): 78. http://dx.doi.org/10.4103/ijmr.ijmr_1753_18.

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Laulhère, J. P., A. M. Labouré, and J. F. Briat. "Photoreduction and incorporation of iron into ferritins." Biochemical Journal 269, no. 1 (1990): 79–84. http://dx.doi.org/10.1042/bj2690079.

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Pea seed ferritin is able to incorporate ferrous iron into the mineral core. Fe2+ may be formed by reduction of exogenous Fe3+ with ascorbate or by photoreduction by ferritin and by ferric citrate. In our experimental conditions the bulk of the photoreduction is carried out by ferritin, which is able to photoreduce its endogenous iron. Citrate does not enhance the photoreduction capacity of ferritin, and exogenous ferric citrate improves the yield of the reaction by about 30%. The mineral core of the ferritin is shown to photoreduce actively, and the protein shell does not participate directly

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Ueda, Y., Y. Imahori, H. Yamanaka, S. Kwak, and K. Chachin. "DIMETHYL SULFIDE PRODUCTION IN STORED SATSUMA MANDARIN : THE POTENTIAL ROLE OF FERROUS ION AND ASCORBATE." Acta Horticulturae, no. 398 (March 1995): 297–304. http://dx.doi.org/10.17660/actahortic.1995.398.31.

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Chikkamath, S., J. Manjanna, N. Momin, et al. "Na-montmorillonite to Fe(II)-Mt using ferrous citrate/ascorbate obtained by dissolving iron powder." Applied Clay Science 217 (February 2022): 106396. http://dx.doi.org/10.1016/j.clay.2021.106396.

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Tvrdá, E., E. Tušimová, A. Kováčik, D. Paál, Ľ. Libová, and N. Lukáč. "Protective Effects of Quercetin on Selected Oxidative Biomarkers in Bovine Spermatozoa Subjected to Ferrous Ascorbate." Reproduction in Domestic Animals 51, no. 4 (2016): 524–37. http://dx.doi.org/10.1111/rda.12714.

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Hazra, Moumita. "A clinical pharmacological evidence-based analytical research study on the clinical pharmacokinetic dose-dependent correlation of oral haematinics with the obstetric and gynaecological global anaemic patients’ recovery rate." International Journal of Basic & Clinical Pharmacology 12, no. 1 (2022): 34. http://dx.doi.org/10.18203/2319-2003.ijbcp20223351.

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Background: The goal of iron therapy is to repair the haemoglobin deficit and replenish storage iron. Oral haematinics are the treatment of choice, due to their higher effectiveness, higher safety, higher ease of administration, higher patient compliance, better accessibility, no occurrence of nosocomial infections and lower cost. This analytical evidence-based clinical research was conducted for the molecular pharmacokinetic study of the pharmacological response and adherence of the patients to oral haematinics, in global tertiary medical care centres.Methods: 100 anaemic patients, who were t

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Ianzini, F., and M. B. Yatvin. "A comparison of X-irradiation and ferrous ion-ascorbate on oxidation of phosphatidylglycerols in multilamellar liposomes." Radiation and Environmental Biophysics 26, no. 1 (1987): 37–46. http://dx.doi.org/10.1007/bf01211363.

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Yewale, Vijay N., and Bhupesh Dewan. "Treatment of Iron Deficiency Anemia in Children: A Comparative Study of Ferrous Ascorbate and Colloidal Iron." Indian Journal of Pediatrics 80, no. 5 (2012): 385–90. http://dx.doi.org/10.1007/s12098-012-0906-6.

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S.B., Sateesha, Hirday Narayan Sah, and Rajamma A.J. "Development of reconstitutable nano-liposome of Ferrous Ascorbate for prophylaxis and treatment of iron deficiency anemia." Asian Journal of Pharmacy and Pharmacology 8, no. 6 (2022): 180–87. http://dx.doi.org/10.31024/ajpp.2022.8.6.3.

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Tschan, T., I. Höerler, Y. Houze, K. H. Winterhalter, C. Richter, and P. Bruckner. "Resting chondrocytes in culture survive without growth factors, but are sensitive to toxic oxygen metabolites." Journal of Cell Biology 111, no. 1 (1990): 257–60. http://dx.doi.org/10.1083/jcb.111.1.257.

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Chondrocytes in dense suspension culture in agarose survive in serum-free DME because they secrete low molecular mass compounds supporting their own viability. This activity can be replaced by pyruvate, or sulfhydryl compounds, e.g., cysteine or dithioerythritol. Catalase, an enzyme decomposing H2O2, also protects the cells, whereas superoxide dismutase has no effect. Therefore, chondrocytes in culture are sensitive to toxic compounds derived from molecular oxygen, i.e., hydroxyl radicals or hydrogen peroxide spontaneously generated in DME containing ascorbate and ferrous ions. Poly-ADP-ribosy

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Jordan, I., and J. Kaplan. "The mammalian transferrin-independent iron transport system may involve a surface ferrireductase activity." Biochemical Journal 302, no. 3 (1994): 875–79. http://dx.doi.org/10.1042/bj3020875.

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Mammalian cells accumulate iron from ferric citrate or ferric nitrilotriacetate through the activity of a transferrin-independent iron transport system [Sturrock, Alexander, Lamb, Craven and Kaplan (1990) J. Biol. Chem. 265, 3139-3145]. The uptake system might recognize and transport ferric-anion complexes, or cells may reduce ferric iron at the surface and then transport ferrous iron. To distinguish between these possibilities we exposed cells to either [59Fe]ferric citrate or ferric [14C]citrate and determined whether accumulation of iron was accompanied by the obligatory accumulation of cit

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Perez, E. G. A., M. Nichi, F. A. Oliveira Neto, et al. "34 OVINE SPERM IS HIGHLY SUSCEPTIBLE TO ATTACK BY HYDROGEN PEROXIDE." Reproduction, Fertility and Development 22, no. 1 (2010): 175. http://dx.doi.org/10.1071/rdv22n1ab34.

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Ram sperm membrane displays a particular lipid composition, especially regarding the high quantity of polyunsaturated cholesterol. This trait improves membrane fluidity; however, the spermatozoa become more susceptible to the attack of reactive oxygen species (ROS), which may lead to structural and functional damage, impairment or even impeded fecundity. The aim of the present experiment was to study the resistance of ovine spermatozoa to different ROS. Sperm samples from 4 rams were collected using an artificial vagina. Sperm samples were then incubated (1 h, 37°C) with four ROS inducer mecha

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Li, He-Min, Ting Gu, Wen-Yu Wu, et al. "Synthesis and Biological Evaluation of Scutellarein Alkyl Derivatives as Preventing Neurodegenerative Agents with Improved Lipid Soluble Properties." Medicinal Chemistry 15, no. 7 (2019): 771–80. http://dx.doi.org/10.2174/1573406414666181015143551.

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Background: Exogenous antioxidants are considered as a promising therapeutic approach to treat neurodegenerative diseases since they could prevent and/or minimize the neuronal damage by oxidation. Objective: Three series of lipophilic compounds structurally based on scutellarein (2), which is one metabolite of scutellarin (1) in vivo, have been designed and synthesized. Methods: Their antioxidant activity was evaluated by detecting the 2-thiobarbituric acid reactive substance (TBARS) produced in the ferrous salt/ascorbate-induced autoxidation of lipids, which were present in microsomal membran

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