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Journal articles on the topic 'Fertility Endocrine aspects'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 January 2023

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1

Szkodziak, Filip, Jarosław Krzyżanowski, and Piotr Szkodziak. "Psychological aspects of infertility. A systematic review." Journal of International Medical Research 48, no. 6 (June 2020): 030006052093240. http://dx.doi.org/10.1177/0300060520932403.

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Objective Fertility may be defined as a capacity to conceive and produce offspring. Infertility is characterized by failure to establish a clinical pregnancy after 12 months of regular and unprotected sexual intercourse. Infertility concerns an estimated 8–12% of the global population, and is associated with factors including time of unwanted non-conception, age of female partner and number of diseases impacting fertility. Unexplained infertility is described as idiopathic. This study aimed to analyse and evaluate the influence of mental disorders, often considered as reasons for idiopathic in

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Leshchenko, O. Ya, E. V. Genich, M. A. Darenskaya, and L. I. Kolesnikova. "HIV and infertility: neuro-endocrine and metabolic aspects." HIV Infection and Immunosuppressive Disorders 12, no. 4 (February 9, 2021): 73–80. http://dx.doi.org/10.22328/2077-9828-2020-12-4-73-80.

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Objective: to establish a correlation of the main neuroendocrine and metabolic parameters associated with infertility and to provide a prognostic assessment of reproductive disorders in HIV-infected women, stages 4.Materials and methods. Cross-sectional, cohort, clinical and sociological study of fertility of 83 women of reproductive age with HIV, stages 4.Results. The most signiﬁcant indicators of lipid peroxidation and neuroendocrine regulation systems have been established in patients with HIV infection and reproductive disorders, which will make it possible to predict these disorders in th

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Kumar, A., S. Raut, and N. H. Balasinor. "Endocrine regulation of sperm release." Reproduction, Fertility and Development 30, no. 12 (2018): 1595. http://dx.doi.org/10.1071/rd18057.

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Spermiation (sperm release) is the culmination of a spermatid’s journey in the seminiferous epithelium. After a long association with the Sertoli cell, spermatids have to finally ‘let go’ of the support from Sertoli cells in order to be transported to the epididymis. Spermiation is a multistep process characterised by removal of excess spermatid cytoplasm, recycling of junctional adhesion molecules by endocytosis, extensive cytoskeletal remodelling and final spermatid disengagement. Successful execution of all these events requires coordinated regulation by endocrine and paracrine factors. Thi

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Arnanz, Ana, Juan A. Garcia-Velasco, and José Luis Neyro. "Calcifediol (25OHD) Deficiency and Its Treatment in Women’s Health and Fertility." Nutrients 14, no. 9 (April 27, 2022): 1820. http://dx.doi.org/10.3390/nu14091820.

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Currently, there is abundant scientific evidence showing that the vitamin D endocrine system (VDES) is a highly complex endocrine system with multiple actions in different regions of the body. The unequivocal presence of vitamin D receptors in different tissues related to fertility, and to specific aspects of women’s health such as pregnancy, undoubtedly implies functions of this steroid hormone in both male and female fertility and establishes relationships with different outcomes of human gestation. In order to review the role of the VDES in human fertility, we evaluated the relationships es

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de Carvalho, Bruno, Ionara Barcelos, Sebastião de Medeiros, Cristina Benetti-Pinto, Daniela Yela, Andrea Nácul, Gustavo Maciel, José Júnior, Ana Carolina Rosa e Silva, and Laura Costa. "Increasing the Chances of Natural Conception: Opinion Statement from the the Brazilian Federation of Gynecology and Obstetrics Associations - FEBRASGO - Committee of Gynecological Endocrinology." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 41, no. 03 (February 15, 2019): 183–90. http://dx.doi.org/10.1055/s-0039-1677838.

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AbstractConsidering that myths and misconceptions regarding natural procreation spread rapidly in the era of easy access to information and to social networks, adequate counseling about natural fertility and spontaneous conception should be encouraged in any kind of health assistance. Despite the fact that there is no strong-powered evidence about any of the aspects related to natural fertility, literature on how to increase the chances of a spontaneous pregnancy is available. In the present article, the Brazilian Federation of Gynecology and Obstetrics Associations (FEBRASGO, in the Portugues

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Ivanova, L. V., L. Sh Gorbacova, and N. L. Nemet. "Modern aspects in the treatment of pelvic inflammatory diseases, associated with intrauterine device contraception and their consequences in the remote period." Journal of obstetrics and women's diseases 48, no. 2 (May 15, 1999): 17–21. http://dx.doi.org/10.17816/jowd88063.

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Pelvic inflammatory diseases are widespread form of women pathology. In many cases these diseases are connected to IUD application and frequently result in violations of specific functions of a female organism. We conduct operation on generalization of data of literary sources, with reference to the given kind of a pathology, analyse the etiology, clinical features, methods of treatment (conservative and surgical), and also paths for restoring fertility and endocrine functions.

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Yding Andersen, C., L. S. Mamsen, and S. G. Kristensen. "FERTILITY PRESERVATION: Freezing of ovarian tissue and clinical opportunities." Reproduction 158, no. 5 (November 2019): F27—F34. http://dx.doi.org/10.1530/rep-18-0635.

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Ovarian tissue cryopreservation (OTC) is mainly used for fertility preservation in girls and women facing a gonadotoxic treatment. If the woman subsequently becomes menopausal, the ovarian tissue may be transplanted to regain ovarian function, including fertility. The method was developed more than two decades ago and today thousands of women worldwide have undergone OTC. Fewer than 500 patients have had tissue transplanted and close to 100% of those regain ovarian function. Several technical aspects of OTC are now becoming more established, including high quantitative follicle survival, defin

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Rojas, Joselyn, Mervin Chávez-Castillo, Luis Carlos Olivar, María Calvo, José Mejías, Milagros Rojas, Jessenia Morillo, and Valmore Bermúdez. "Physiologic Course of Female Reproductive Function: A Molecular Look into the Prologue of Life." Journal of Pregnancy 2015 (2015): 1–21. http://dx.doi.org/10.1155/2015/715735.

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The genetic, endocrine, and metabolic mechanisms underlying female reproduction are numerous and sophisticated, displaying complex functional evolution throughout a woman’s lifetime. This vital course may be systematized in three subsequent stages: prenatal development of ovaries and germ cells up untilin uteroarrest of follicular growth and the ensuing interim suspension of gonadal function; onset of reproductive maturity through puberty, with reinitiation of both gonadal and adrenal activity; and adult functionality of the ovarian cycle which permits ovulation, a key event in female fertilit

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Schuenemann, G. M., J. L. Edwards, F. M. Hopkins, N. R. Rohrbach, H. S. Adair, F. N. Scenna, J. C. Waller, J. W. Oliver, A. M. Saxton, and F. N. Schrick. "Fertility aspects in yearling beef bulls grazing endophyte-infected tall fescue pastures." Reproduction, Fertility and Development 17, no. 4 (2005): 479. http://dx.doi.org/10.1071/rd05005.

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During a 2-year study, yearling beef bulls were used to determine the effects of grazing on endophyte-infected tall fescue on endocrine profiles, semen quality and fertilisation potential. Bulls were allotted to graze tall fescue pastures infected with Neotyphodium coenophialum (E+; n = 20 per year) or Jesup/MaxQTM (Pennington Seed, Atlanta, GA, USA; NTE; n = 10 per year). Bulls were grouped by scrotal circumference (SC), bodyweight (BW), breed composites and age to graze tall fescue pastures from mid-November until the end of June (within each year). Blood samples, BW, SC and rectal temperatu

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Yaw, Alexandra, Autumn McLane-Svoboda, and Hanne Hoffmann. "Shiftwork and Light at Night Negatively Impact Molecular and Endocrine Timekeeping in the Female Reproductive Axis in Humans and Rodents." International Journal of Molecular Sciences 22, no. 1 (December 30, 2020): 324. http://dx.doi.org/10.3390/ijms22010324.

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Shiftwork, including work that takes place at night (nightshift) and/or rotates between day and nightshifts, plays an important role in our society, but is associated with decreased health, including reproductive dysfunction. One key factor in shiftwork, exposure to light at night, has been identified as a likely contributor to the underlying health risks associated with shiftwork. Light at night disrupts the behavioral and molecular circadian timekeeping system, which is important for coordinated timing of physiological processes, causing mistimed hormone release and impaired physiological fu

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Tang, Tian, Jinghan Yang, and Siyuan Jing. "A Preliminary Study on the Mechanism of Premature Ovarian Failure." Proceedings of Anticancer Research 5, no. 4 (July 29, 2021): 34–39. http://dx.doi.org/10.26689/par.v5i4.2318.

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Premature ovarian failure (POF) refers to the failure of ovaries which causes amenorrhea before the age of 40. It is characterized by primary or secondary amenorrhea along with elevated blood gonadotropin levels and decreased estrogen levels with varying degrees of low estrogen symptoms such as hot flashes and sweating, facial flushing, reduced libido, and so on. Premature ovarian failure (POF) is a common endocrine disease in gynecology. The incidence of POF is increasing year by year and the affected population increasingly involves the younger-aged groups. Its etiology is complex and divers

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CARSOTE, Mara, Diana Elena RENTEA, Aida PETCA, Stefania ZUGRAVU, Claudia MEHEDINTU, Florica SANDRU, Anda DUMITRASCU, and Mihai Cristian DUMITRASCU. "Endocrine issues and premenopausal breast cancer – case report and review of literature." Romanian Journal of Medical Practice 16, no. 4 (December 31, 2021): 533–39. http://dx.doi.org/10.37897/rjmp.2021.4.25.

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There is an alarming increasing incidence of PBC (premenopausal breast cancer) in countries with high income due to, on one hand, more accessible screening tools and, on the other hand, potential implications of daily lifestyle habits and endocrine disruptors of modern society on terms of facilitating tumor growth. A more severe prognostic is found in females younger than 40 years old at first detection, with advanced disease at diagnostic, and those with tumors displaying specific immunohistochemistry configuration (and associated gene profile) like ER (estrogen receptor) positive or HEGFR2 (

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de Graaf, Johan P., Friso de Vries, Anne Dirkson, Olaf Hiort, Alberto M. Pereira, Márta Korbonits, and Martine Cools. "Patients with rare endocrine conditions have corresponding views on unmet needs in clinical research." Endocrine 71, no. 3 (February 3, 2021): 561–68. http://dx.doi.org/10.1007/s12020-021-02618-z.

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Abstract Purpose European Reference Network on Rare Endocrine Conditions' (Endo-ERN) mission is to reduce and ultimately abolish inequalities in care for patients with rare endocrine conditions in Europe. This study assesses which themes related to rare endocrine conditions are prioritized by patients for clinical research. Methods A survey was developed, translated into 22 different European languages, and distributed to patients with rare endocrine conditions. Patients were asked to give priority scores to listed prespecified topics: fertility, heritability, tiredness, daily medicine intake,

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Damiani, Durval, Marc Fellous, Ken McElreavey, Sandrine Barbaux, Elenilde S. A. Barreto, Vaê Dichtchekenian, and Nuvarte Setian. "True hermaphroditism: clinical aspects and molecular studies in 16 cases." European Journal of Endocrinology 136, no. 2 (February 1997): 201–4. http://dx.doi.org/10.1530/eje.0.1360201.

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Abstract Although true hermaphroditism (TH) accounts for less than 10% of intersex patients, it stands as a diagnostic challenge and has allowed a better understanding of the mechanisms involved in sexual differentiation. In this paper we review the clinical and laboratory data as well as molecular biology findings on 16 TH patients followed up at the Pediatric Endocrine Unit, Instituto da Criança, Hospital das Clínicas, São Paulo University Medical School. They were of a mean age of 3 years 8 months and nine of them were black. All the patients had ambiguous external genitalia as the main com

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Carsote, Mara, Cristina Vasiliu, Alexandra Ioana Trandafir, Simona Elena Albu, Mihai-Cristian Dumitrascu, Adelina Popa, Claudia Mehedintu, Razvan-Cosmin Petca, Aida Petca, and Florica Sandru. "New Entity—Thalassemic Endocrine Disease: Major Beta-Thalassemia and Endocrine Involvement." Diagnostics 12, no. 8 (August 9, 2022): 1921. http://dx.doi.org/10.3390/diagnostics12081921.

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Beta-thalassemia (BTH), a recessively inherited haemoglobin (Hb) disorder, causes iron overload (IO), extra-medullary haematopoiesis and bone marrow expansion with major clinical impact. The main objective of this review is to address endocrine components (including aspects of reproductive health as fertility potential and pregnancy outcome) in major beta-thalassemia patients, a complex panel known as thalassemic endocrine disease (TED). We included English, full-text articles based on PubMed research (January 2017–June 2022). TED includes hypogonadism (hypoGn), anomalies of GH/IGF1 axes with

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Trummer, Christian, Stefan Pilz, Verena Schwetz, Barbara Obermayer-Pietsch, and Elisabeth Lerchbaum. "Vitamin D, PCOS and androgens in men: a systematic review." Endocrine Connections 7, no. 3 (March 2018): R95—R113. http://dx.doi.org/10.1530/ec-18-0009.

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Background Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the reproductive system in both genders. Aim The aim of this review was to provide an overview on the effects of vitamin D on polycystic ovary syndrome (PCOS) in women and androgen metabolism in men. Methods We performed a systematic literature search in PubMed for relevant English language publications published from January 2012 until September 2017. Results and discussion The vitamin D receptor and vitamin D-metabolizing enzymes are found in reproductive tissues of women a

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Allen, Cathy. "Health and Disease After Assisted Reproductive Technology." Fertility & Reproduction 01, no. 03 (September 2019): 122–25. http://dx.doi.org/10.1142/s2661318219300095.

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Long-term health outcomes after ART have largely focused on offspring health and perinatal parameters. Longer-term health outcomes in female patients remain difficult to fully assess. Hypothetical concerns about the effects of endocrine manipulation on hormone-sensitive conditions, e.g. breast disease, are confounded by variable factors in patients and treatments. Obstetric and perinatal factors endow an additional layer of complexity to the overall analysis and more research is required to appreciate all aspects of ART. Notwithstanding the knowledge gap, clinicians must endeavour to individua

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O'Connor, Annalouise, James Gibney, and Helen M. Roche. "Metabolic and hormonal aspects of polycystic ovary syndrome: the impact of diet." Proceedings of the Nutrition Society 69, no. 4 (August 10, 2010): 628–35. http://dx.doi.org/10.1017/s0029665110002016.

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Polycystic ovary syndrome (PCOS) is a common, chronic endocrine condition affecting young women of reproductive age. It is characterised by hyperandrogenaemia, and profound menstrual and ovulatory dysfunction with consequent sub-fertility. A clustering of metabolic aberrations is commonly associated with this condition and these include insulin resistance, disordered lipid metabolism and chronic low-grade inflammation. Overweight and obesity, as well as a degree of adipose tissue dysfunction, are present in a large proportion of women with PCOS, and where present, magnify the inherent hyperand

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Tzvetkova, P. "Congenital anomalies of the mesonephronic duct and fertility." Acta chirurgica Iugoslavica 54, no. 2 (2007): 63–67. http://dx.doi.org/10.2298/aci0702063t.

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Agenesia of deferential duct and the others congenital malformations of mesonephronical duct are often encountering condition in andrological practice. This study presents the possibilities of reproductive medicine to restore the male fertility and concentrates on biological and clinical aspects of malformations of mesonephronic duct like factors for excretory male infertility. The investigations including 104 patients (mean age 30.25+1.91 years old) with congenital anomalies of mesonephronical duct with: Agenesia of mesonephronical derivates - case with unilateral agenesia of the deferent duc

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El. Khoury, Diala, Salma Fayjaloun, Marc Nassar, Joseph Sahakian, and Pauline Y. Aad. "Updates on the Effect of Mycotoxins on Male Reproductive Efficiency in Mammals." Toxins 11, no. 9 (September 3, 2019): 515. http://dx.doi.org/10.3390/toxins11090515.

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Mycotoxins are ubiquitous and unavoidable harmful fungal products with the ability to cause disease in both animals and humans, and are found in almost all types of foods, with a greater prevalence in hot humid environments. These mycotoxins vary greatly in structure and biochemical effects; therefore, by better understanding the toxicological and pathological aspects of mycotoxins, we can be better equipped to fight the diseases, as well as the biological and economic devastations, they induce. Multiple studies point to the association between a recent increase in male infertility and the inc

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Valentim, Jean Kaique, Janaína Palermo Mendes, Bruna Barreto Przybulinski, Felipe Cardoso Serpa, Deivid Kelly Barbosa, Vivian Aparecida Rios Castilho, and Rita Therezinha Rolim Pietramale. "Fatores Nutricionais Aplicados à Reprodução de Ruminantes." UNICIÊNCIAS 23, no. 2 (December 4, 2019): 77. http://dx.doi.org/10.17921/1415-5141.2019v23n2p77-82.

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Os animais de produção estão sendo modificados através de um intenso melhoramento genético, buscando intensificar seu desempenho para atender a demanda mundial em quesitos de alimentação. Essa maximização de desempenho demanda um acréscimo nutricional, e este por sua vez pode afetar as funções reprodutivas. Vários estudos mostram que a reprodução pode ser comprometida se as necessidades nutricionais dos animais não forem atendidas. Esta demanda nutricional afeta diretamente a função dos órgãos reprodutivos e o funcionamento do sistema endócrino, podendo interferir na taxa de fertilidade destes

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Foresta, Carlo, Daniela Zuccarello, Andrea Garolla, and Alberto Ferlin. "Role of Hormones, Genes, and Environment in Human Cryptorchidism." Endocrine Reviews 29, no. 5 (August 1, 2008): 560–80. http://dx.doi.org/10.1210/er.2007-0042.

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Abstract Cryptorchidism is the most frequent congenital birth defect in male children (2–4% in full-term male births), and it has the potential to impact the health of the human male. In fact, although it is often considered a mild malformation, it represents the best-characterized risk factor for reduced fertility and testicular cancer. Furthermore, some reports have highlighted a significant increase in the prevalence of cryptorchidism over the last few decades. Etiology of cryptorchidism remains for the most part unknown, and cryptorchidism itself might be considered a complex disease. Majo

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Giommi, Christian, Hamid R. Habibi, Michela Candelma, Oliana Carnevali, and Francesca Maradonna. "Probiotic Administration Mitigates Bisphenol A Reproductive Toxicity in Zebrafish." International Journal of Molecular Sciences 22, no. 17 (August 27, 2021): 9314. http://dx.doi.org/10.3390/ijms22179314.

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Although the use of bisphenol A (BPA) has been banned in a number of countries, its presence in the environment still creates health issues both for humans and wildlife. So far, BPA toxicity has been largely investigated on different biological processes, from reproduction to development, immune system, and metabolism. In zebrafish, Danio rerio, previous studies revealed the ability of environmentally relevant concentrations of this contaminant to significantly impair fertility via epigenetic modification. In addition, several studies demonstrated the ability of different probiotic strains to

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Seshagiri, Polani B., and Venkatappa Vani. "Research on early mammalian development in India." International Journal of Developmental Biology 64, no. 1-2-3 (2020): 109–21. http://dx.doi.org/10.1387/ijdb.190189ps.

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Historically, research in India on early mammalian development had only begun, rather modestly, in the last century, unlike the USA and UK. In India, initial studies were on gonadal and reproductive tissue development and function and they were limited to anatomical and histological characterization. This was followed by research on fertility regulation and contraception. Since the 1960s, a major initiative took place regarding endocrine biochemistry and the use of antifertility agents in inhibiting gonadal function and early development. Post-independence, the Indian government´s funding supp

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Charazac, Aurélie, Charlotte Hinault, Bastien Dolfi, Solène Hautier, Célia Decondé Le Butor, Frédéric Bost, and Nicolas Chevalier. "Low Doses of PFOA Promote Prostate and Breast Cancer Cells Growth through Different Pathways." International Journal of Molecular Sciences 23, no. 14 (July 18, 2022): 7900. http://dx.doi.org/10.3390/ijms23147900.

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Endocrine Disrupting Compounds (EDCs) are found in everyday products. Widely distributed throughout the environment, persistent organic pollutants (POPs) are a specific class of EDCs that can accumulate in adipose tissue. Many of them induce adverse effects on human health—such as obesity, fertility disorders and cancers—by perturbing hormone effects. We previously identified many compounds with EDC activity in the circulation of obese patients who underwent bariatric surgery. Herein, we analyzed the effects of four of them (aldrin, BDE28, PFOA and PCB153) on two cancer cell lines of hormone-s

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Gerardi, Chiara, Eleonora Allocati, Carla Minoia, Attilio Guarini, and Rita Banzi. "Long-Term Follow-Up of Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma Survivors: Aims and Methodological Approach for Fondazione Italiana Linfomi Systematic Reviews." Cancers 13, no. 12 (June 14, 2021): 2976. http://dx.doi.org/10.3390/cancers13122976.

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Advances in diagnosis and treatment of hematological malignancies has boosted attention on optimal follow-up care of survivors after cancer. To collect evidence that could inform the development of an optimal model for Italian hematology centers and the scientific community, Fondazione Italiana Linfomi (FIL) commissioned an analysis of the international follow-up approaches for long-term survivors after classical Hodgkin lymphoma (cHL) or diffuse large B-cell lymphoma (DLBCL). FIL set up multidisciplinary teams, representing all different skills relevant for cancer survivors. They conducted a

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Penas-Prado, Marta, Terri S. Armstrong, and Mark R. Gilbert. "Proposed Additions to the NCCN Guidelines for Adult Medulloblastoma." Journal of the National Comprehensive Cancer Network 18, no. 11 (November 2020): 1579–84. http://dx.doi.org/10.6004/jnccn.2020.7650.

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Medulloblastoma is a rare brain tumor that occurs in both children and adults, with patients aged 15 to 39 years accounting for 30% of all cases. In adults, guidelines for diagnosis and treatment are often based on retrospective data and extrapolated from the pediatric experience due to limited availability of prospective trials or registries involving adults. Importantly, adult patients differ from pediatric patients in many aspects, including the molecular features of the tumor and tolerance to treatment. In 2017, the NCI was granted support from the Cancer Moonshot initiative to address the

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Karjula, Salla, Riikka K. Arffman, Laure Morin-Papunen, Stephen Franks, Marjo-Riitta Järvelin, Juha S. Tapanainen, Jouko Miettunen, and Terhi T. Piltonen. "A population-based follow-up study shows high psychosis risk in women with PCOS." Archives of Women's Mental Health 25, no. 2 (November 29, 2021): 301–11. http://dx.doi.org/10.1007/s00737-021-01195-4.

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AbstractPolycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 18% of women. Besides metabolic and fertility aspects, attention has lately been directed towards the detrimental effect of PCOS on psychological health. The objective of the study was to investigate whether women with PCOS are at higher risk for psychotic disorders. The study population derives from the Northern Finland Birth Cohort 1966 (N = 5889 women). The women with PCOS were identified by two simple questions on oligo-amenorrhea and hirsutism at age 31. Women reporting both symptoms were considered PC

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Mancini, Vanessa, and Virginia Pensabene. "Organs-On-Chip Models of the Female Reproductive System." Bioengineering 6, no. 4 (November 7, 2019): 103. http://dx.doi.org/10.3390/bioengineering6040103.

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Microfluidic-based technology attracts great interest in cell biology and medicine, in virtue of the ability to better mimic the in vivo cell microenvironment compared to conventional macroscale cell culture platforms. Recent Organs-on-chip (OoC) models allow to reproduce in vitro tissue and organ-level functions of living organs and systems. These models have been applied for the study of specific functions of the female reproductive tract, which is composed of several organs interconnected through intricate endocrine pathways and communication mechanisms. To date, a disease and toxicology st

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AVERY, Jodie, Stephanie PIROTTA, Geranne JISKOOT, and Melanie GIBSON-HELM. "Scoping Appropriate Quality of Life Dimensions for the Development of a Meaningful Quality of Life Tool for PCOS. The “HERAQoL-P”." Fertility & Reproduction 04, no. 03n04 (September 2022): 173. http://dx.doi.org/10.1142/s266131822274084x.

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Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine condition in women, with a range of symptoms related to problems with fertility, weight gain, mental health and sleep, and is not a stable condition over the life course. Women with PCOS have different experiences of Quality of Life (QoL) depending on their age, ethnicity, socio economic status, severity and phenotype. QoL is an important health outcome, yet measures include predefined items, that may be unimportant to individuals. Existing PCOS QoL measures may not capture the full physical, emotional, and social impact of PCO

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Torti, Lorenza, Laura Maffei, Francesco Sorrentino, Paolo De Fabritiis, Donatella Dell'Anna, Maurizio Poggi, Stefano Aureli, Giovanni Loyola, Rocco Rago, and Elisabetta Abruzzese. "New Perspectives and Challenges Regarding Fertility, Conception and Pregnancy in Hemoglobinopathies. a Multidisciplinary Report of 66 Outcomes." Blood 136, Supplement 1 (November 5, 2020): 22–23. http://dx.doi.org/10.1182/blood-2020-134563.

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Introduction Major thalassemia (TM) and sickle cell disease (SCD), two common genetic hemoglobinopathies, were often fatal 50 years ago. Novel therapeutic and diagnostic methods are increasing lifespan and quality of life. Recent advances in iron chelation for transfusion-dependent hemoglobinopathies have significant improved patient prognosis. Young adult TM and SCD patients often ask about the possibility of conception and pregnancy. The increase in the worldwide movement of carriers and subjects has lead to new cultural, ethical and psychosocial aspects that must be taken into consideration

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Panieri, Emiliano, Aleksandra Buha-Đorđevic, and Luciano Saso. "Endocrine disruption by PFAS: A major concern associated with legacy and replacement substances." Arhiv za farmaciju 71, no. 6 (2021): 429–54. http://dx.doi.org/10.5937/arhfarm71-34197.

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Perand poly-fluorinated alkyl substances (PFAS) have been used for decades in a great variety of processes and products by virtue of their exceptional properties, versatility and chemical stability. Nevertheless, it is increasingly recognized that these substances can represent a serious hazard to human health and living organisms due to their persistence, long-range transport potential and tendency to accumulate in biota. For this reason, some efforts have been made across the EU to identify alternative molecules, with a shorter carbon chain and theoretically safer profile, that might replace

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Herbert, C. A., T. E. Trigg, M. B. Renfree, G. Shaw, D. C. Eckery, and D. W. Cooper. "Long-term effects of deslorelin implants on reproduction in the female tammar wallaby (Macropus eugenii)." Reproduction 129, no. 3 (March 2005): 361–69. http://dx.doi.org/10.1530/rep.1.00432.

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The contraceptive and endocrine effects of long-term treatment with implants containing the GnRH agonist deslorelin were investigated in female tammar wallabies (Macropus eugenii). Fertility was successfully inhibited for 515 ± 87 days after treatment with a 5 mg deslorelin implant (n= 7), while control animals gave birth to their first young 159 ± 47 days after placebo implant administration (n= 8). The duration of contraception was highly variable, ranging from 344 to 761 days. The strict reproductive seasonality in the tammar wallaby was maintained once the implant had expired. This inhibit

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Orenchuk, I. V., and O. G. Boychuk. "PREDICTION OF UTERINE FACTOR OF INFERTILITY IN LATE REPRODUCTIVE AGE WOMEN." Art of Medicine 22, no. 2 (July 20, 2022): 75–79. http://dx.doi.org/10.21802/artm.2022.2.22.75.

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Restoration of women's reproductive health in modern conditions is a multifactorial problem for specialists (obstetricians, gynecologists, endocrinologists, hematologists, therapists), often requiring the use of assisted reproductive technologies (ART) [1,3]. According to available data, 46.7% of women who need ART have primary infertility, 53.3% have secondary infertility, and the average age is less than 35 years [2,4]. Despite the fact that only 10-20% of married couples have a verified cause of infertility, in most cases the etiopathogenesis of impaired fertility cannot be corrected [5,6].

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Pocar, P., TA Brevini, B. Fischer, and F. Gandolfi. "The impact of endocrine disruptors on oocyte competence." Reproduction, March 1, 2003, 313–25. http://dx.doi.org/10.1530/rep.0.1250313.

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To date, approximately 60 chemicals have been identified as endocrine disruptors: exogenous agents that interfere with various aspects of natural hormone physiology. The potential reproductive and health hazards of these environmental chemicals have recently generated concern among the scientific community, policy makers and general public. The present review presents and discusses the available evidence that environmental chemicals are causing ovarian toxicity in various species, with particular attention to farm animals. The impact of chronic exposure to endocrine disruptors via food and dri

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Pereira, Nigel, and Karen Lin-Su. "Reproductive Function and Fertility in Women with Congenital Adrenal Hyperplasia." EMJ Reproductive Health, August 16, 2018, 101–7. http://dx.doi.org/10.33590/emjreprohealth/10314092.

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Congenital adrenal hyperplasia (CAH) refers to a group of disorders that are associated with defective adrenal steroidogenesis, the most common of which is 21-hydroxylase deficiency. The advent of neonatal screening, molecular genetics, and glucocorticoid and mineralocorticoid replacement has vastly improved the diagnosis and treatment of CAH; therefore, most infants and children with CAH successfully transition into adulthood. Several quality-of-life issues emanate from this transition, of which reproduction and fertility are notable. In this review, the authors appraise the effects of elevat

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Bettocchi, Carlo, Marco Rinaldi, and Francesco Sebastiani. "GnRH in the treatment of Hypogonadotropic hypogonadism." Current Pharmaceutical Design 26 (November 25, 2020). http://dx.doi.org/10.2174/1381612826666201125113319.

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: Gonadotropin Releasing Hormone (GnRH) is at the centre of the scientific debate for the treatment of hypogonadotropic hypogonadism. Sexual maturation and reproductive function depend on the pulsatile secretion of GnRH are mainly congenital and may or may not be associated with other genetic anomalies or syndromes. Clinical manifestations include a wide range of metabolic, endocrine and psychologic dysfunctions. The following manuscript focuses on the effects of GnRH therapy on fertility and cognitive abilities, aiming to investigate the current level of evidence for this treatment regimen. C

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Mattia, Lorenza, Irene Samperi, Salvatore Monti, Vincenzo Toscano, Giuseppe Pugliese, and Maurizio Poggi. "The Quality of Life of Thalassemic Patients: The Role of Endocrine Defect Compensation." Endocrine, Metabolic & Immune Disorders - Drug Targets 21 (April 21, 2021). http://dx.doi.org/10.2174/1871530321666210421123759.

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Background: The improvement of beta thalassaemia treatments has led to an increase in life expectancy. This implies the emergence of new comorbidities. Amongst others, endocrine glands are extremely sensitive to iron overload. Objective: We aimed to understand the burden of the endocrine conditions on the patient’s quality of life (QOL). Results: Hypogonadism may present with lack or delay of pubertal development, sexual dysfunctions and impaired fertility, which impact QOL in both sexes. Early recognition and treatment, as well as choosing the most appropriate therapy, according to patient’s

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Lu, Yen-Shen, Andrea Wong, and Hee-Jeong Kim. "Ovarian Function Suppression With Luteinizing Hormone-Releasing Hormone Agonists for the Treatment of Hormone Receptor-Positive Early Breast Cancer in Premenopausal Women." Frontiers in Oncology 11 (September 14, 2021). http://dx.doi.org/10.3389/fonc.2021.700722.

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Chemotherapy and endocrine therapies are mainstays of treatment for early and advanced hormone receptor-positive (HR+) breast cancer. In premenopausal women with HR+ tumors, the benefits of adding ovarian function suppression (OFS) to endocrine therapy have been debated. Consequently, for many years, tamoxifen monotherapy has been the standard of care for endocrine treatment in the adjuvant setting. Recent studies have, however, provided new evidence that, in some premenopausal patients, OFS in combination with tamoxifen or aromatase inhibitors (AIs) can significantly increase survival versus

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Rizzo, Gianluca, Alessandra Feraco, Maximilian Andreas Storz, and Mauro Lombardo. "The role of soy and soy isoflavones on women's fertility and related outcomes: an update." Journal of Nutritional Science 11 (2022). http://dx.doi.org/10.1017/jns.2022.15.

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Abstract Soy is a key food in human nutrition. It is widely used in eastern traditional cuisine and it has recently diffused among self-conscious and vegetarian diets. The success of soy mainly depends on versatility and supposed healthy properties of soy foods and soy components. Meanwhile, the possible influence on endocrine system, in particular by isoflavones, raised concerns among some researchers. The present paper aims to conduct a review of available data on the effect of soy, soy foods and soy components on women's fertility and related outcomes. Eleven interventional studies, eleven

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Jafardoust Bostani, Rashid, and Maryam Parvini Kohneshahri. "Polycystic Ovarian Syndrome: Clinical Features, Genetics of Disease, and Diagnosis Criteria." Journal of Shahid Sadoughi University of Medical Sciences, August 24, 2021. http://dx.doi.org/10.18502/ssu.v29i6.6990.

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Introduction: The polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting 7-10% of women in reproductive age. PCOS is generally characterized by hirsutism, hyperandrogenism, and polycystic ovaries. Insulin resistance is the hallmark of PCOS with a considerable prevalence. Despite numerous studies, the etiology of PCOS haas not been cleared yet; PCOS is considered a multifactorial syndrome with a wide range of genetic, endocrine, molecular, and environmental abnormalities. Altered expression of several genes and miRNAs in PCOS patients has become a useful and non-invasive me

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Pereira, Madison, Kathy Matuszewska, Colin Jamieson, and Jim Petrik. "Characterizing Endocrine Status, Tumor Hypoxia and Immunogenicity for Therapy Success in Epithelial Ovarian Cancer." Frontiers in Endocrinology 12 (November 17, 2021). http://dx.doi.org/10.3389/fendo.2021.772349.

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Epithelial ovarian cancer is predominantly diagnosed at advanced stages which creates significant therapeutic challenges. As a result, the 5-year survival rate is low. Within ovarian cancer, significant tumor heterogeneity exists, and the tumor microenvironment is diverse. Tumor heterogeneity leads to diversity in therapy response within the tumor, which can lead to resistance or recurrence. Advancements in therapy development and tumor profiling have initiated a shift from a “one-size-fits-all” approach towards precision patient-based therapies. Here, we review aspects of ovarian tumor hetero

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Gnocchi, Margherita, Tiziana D’Alvano, Claudia Lattanzi, Giulia Messina, Maddalena Petraroli, Viviana D. Patianna, Susanna Esposito, and Maria E. Street. "Current evidence on the impact of the COVID-19 pandemic on paediatric endocrine conditions." Frontiers in Endocrinology 13 (August 5, 2022). http://dx.doi.org/10.3389/fendo.2022.913334.

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Severe acute respiratory coronavirus 2 (SARS-CoV-2) interacts with the host cells through its spike protein by binding to the membrane enzyme angiotensin-converting enzyme 2 (ACE2) and it can have a direct effect on endocrine function as ACE2 is expressed in many glands and organs with endocrine function. Furthermore, several endocrine conditions have features that might increase the risk of SARS-CoV-2 infection and the severity and course of the infection, as obesity for the underlying chronic increased inflammatory status and metabolic derangement, and for the possible changes in thyroid fun

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Dhami, A. J., J. H. Chauhan, K. K. Hadiya, and N. P. Sarvaiya. "Ovarian Dynamics, Plasma Endocrine Profile and Fertility Response Following Synchronization Protocols in Crossbred Cows with Cystic Ovaries." Indian Journal of Animal Research, OF (July 11, 2020). http://dx.doi.org/10.18805/ijar.b-3944.

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Background: Cystic ovarian degeneration (COD) with prevalence of 10-13% is a common and economically important condition in dairy cattle affecting fertility. Predisposing factors and aetiology of ovarian cysts are multifaceted. The most widely accepted cause is either absent, insufficient or wrong time occurrence of pre-ovulatory LH-surge. The accuracy of differential diagnosis of cyst per rectum can be increased by simultaneous use of USG and/or plasma progesterone assay and therapeutic success depends on type and duration of cystic condition. The literature on these aspects in crossbred cows

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Sengupta, Pallav, Sulagna Dutta, Ivan Rolland Karkada, Roland Eghoghosoa Akhigbe, and Suresh V. Chinni. "Irisin, Energy Homeostasis and Male Reproduction." Frontiers in Physiology 12 (September 21, 2021). http://dx.doi.org/10.3389/fphys.2021.746049.

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Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain-containing protein 5 (FNDC5). It is involved in the browning of white adipose tissue, glucose tolerance, and reversing of metabolic disruptions. Fertility is closely linked to energy metabolism and the endocrine function of the adipose tissue. Moreover, there is established association between obesity and male infertility. Irisin bears strong therapeutic promise in obesity and its associated disorders, as well as shown

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Luz, Gabriela Bueno, Andressa Stein Maffi, Eduardo Gularte Xavier, Marcio Nunes Correa, Bernardo Garziera Gasperin, and Cassio Cassal Brauner. "Endocrine Profile and Reproductive Performance in Heifers Induced to Lactation." Acta Scientiae Veterinariae 47, no. 1 (May 13, 2019). http://dx.doi.org/10.22456/1679-9216.92095.

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Background: Low reproductive efficiency has been one of the main factors that lead to dairy herd culling in the reproductive age. In multiparous animals, such inefficiency and culling can occur because of various factors and may be associated with occasional endocrine failures. To avoid revenue losses that incur due to lack of lactation, lactation is artificially induced in the animals that are not pregnant, using a defined protocol. The aim of this study was, therefore, to evaluate and compare the reproductive performance of heifers submitted to the induction protocol with that of pregnant he

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Souza, Natália Freitas, Washington Luiz Assunção Pereira, Sara Letícia Dos Santos Andrade, Marcio Alan Oliveira Mour, Victor Da Costa Mileo, Moises Moreira Lima, Sebastião Tavares Rolim Filho, and Adriana Maciel de Castro Cardoso Jaques. "Epidermoid Polycystic Ovaries and Uterine Hypoplasia in a Cow." Acta Scientiae Veterinariae 48 (February 25, 2020). http://dx.doi.org/10.22456/1679-9216.100608.

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Background: Ovarian cysts originate from mature follicles that do not ovulate within the predicted time according to the oestrous cycle. Dermoid cysts are structures lined by keratinized stratified squamous epithelium, without adjacent epidermal structures, filled by keratinic debris and amorphous proteinaceus material. They are small, located below the cortex, near the hilus. There is controversy regarding the teratogenicity of the dermoid cyst. Some authors use the nomenclature of benign cystic ovarian teratoma, others, reports that although the fibrous wall and histological features are sim

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