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Journal articles on the topic 'Ferulic acid (FA)'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Kaczmarek, Beata, Katarzyna Lewandowska, and Alina Sionkowska. "Modification of Collagen Properties with Ferulic Acid." Materials 13, no. 15 (2020): 3419. http://dx.doi.org/10.3390/ma13153419.

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Collagen materials are widely used in biomedicine and in cosmetics. However, their properties require improvement for several reasons. In this work, collagen solution as well as collagen films were modified by the addition of ferulic acid (FA). Thin collagen films containing FA were obtained by solvent evaporation. The properties of collagen solution have been studied by steady shear tests. The structure and surface properties of collagen thin films were studied. It was found that for collagen solution with 5% addition of FA, the apparent viscosity was the highest, whereas the collagen solutio

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2

Kondo, Tsuneo, Tomoko Ohshita, and Tadashi Kyuma. "Ester- and ether-linked phenolic acids in orchardgrass (Dactylis glomerata L.) and their digestion from cell walls when fed to sheep." Canadian Journal of Plant Science 71, no. 4 (1991): 1179–82. http://dx.doi.org/10.4141/cjps91-165.

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Ester- and ether-linked p-coumaric (PCA) and ferulic acids (FA) in cell wall materials from orchardgrass (Dactylis glomerata L.), hays harvested at the heading stage and feces samples from sheep fed the orchardgrass hays were analyzed. Results showed that ether-linked PCA and FA were more resistant to ruminant digestion and enzymatic degradation than ester-linked PCA and FA. Key words: p-coumaric acid, esters, ethers, ferulic acid, orchardgrass, sheep digestion

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3

Zhang, Chao, Xiao Fei Guo, Yue Ma, and Xiao Yan Zhao. "Effect of Ferulic Acid and its Oxide on Qualities of Soy Protein-Isolate/Chitosan Composite Films." Applied Mechanics and Materials 716-717 (December 2014): 24–27. http://dx.doi.org/10.4028/www.scientific.net/amm.716-717.24.

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The effect of ferulic acid (FA) and oxidized ferulic acid (OFA) on performances of the soybean protein-isolate/chitosan composite films was evaluated. The FA and OFA showed an excellent compatibility and miscibility of in the composite films, and leaded the surface more compact and smooth. The FA and OFA also enhanced the thermal stability of the composite films. The FA and OFA enhanced the performance of the composite films by raising the band energy of the crosslinked molecules.

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4

Lee, Jaeok, Song Wha Chae, LianJi Ma, et al. "Pharmacokinetic Alteration of Paclitaxel by Ferulic Acid Derivative." Pharmaceutics 11, no. 11 (2019): 593. http://dx.doi.org/10.3390/pharmaceutics11110593.

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P-glycoprotein (P-gp) is known to be involved in multidrug resistance (MDR) and modulation of pharmacokinetic (PK) profiles of substrate drugs. Here, we studied the effects of synthesized ferulic acid (FA) derivatives on P-gp function in vitro and examined PK alteration of paclitaxel (PTX), a well-known P-gp substrate drug by the derivative. Compound 5c, the FA derivative chosen as a significant P-gp inhibitor among eight FA candidates by in vitro results, increased PTX AUCinf as much as twofold versus the control by reducing PTX elimination in rats. These results suggest that FA derivative ca

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5

Bai, Jie, Chang Yang, Shou-Ying Du, et al. "Penetration and pharmacokinetics of ferulic acid after dermal administration." Tropical Journal of Pharmaceutical Research 18, no. 4 (2021): 843–49. http://dx.doi.org/10.4314/tjpr.v18i4.23.

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Purpose: To study the in vitro penetration and in vivo pharmacokinetics of ferulic acid (FA), and the correlation between them after dermal administration. Methods: Franz diffusion cell was used to study in vitro penetration of FA. The concentration of FA in the Franz receiver solution was assessed by high performance liquid chromatography (HPLC). Prior to in vivo pharmacokinetics experiments, probe recovery was validated with respect to influencing factors such as flow rate, FA concentration, within-day stability and reproducibility of the probes. In in vivo pharmacokinetic experiment,

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6

He, Ying, Yuan Jia, and Fachuang Lu. "New Products Generated from the Transformations of Ferulic Acid Dilactone." Biomolecules 10, no. 2 (2020): 175. http://dx.doi.org/10.3390/biom10020175.

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Various ferulic acid (FA) dimers occurring in plant cell walls, such as 8-5-, 8-O-4-, 5-5-, and 8-8-coupled dimers, are effective antioxidants and potential antimicrobials. It is necessary to access these diferulates as reference compounds to validate those isolated from plants. 3,6-bis(4-hydroxy-3-methoxyphenyl)-tetrahydrofuro-[3,4-c]furan-1,4-dione, a 8-8-coupled FA dilactone generated from ferulic acid via radical coupling, has been used to synthesize 8-8-coupled FA dimers although few reports investigated the distribution of products and mechanisms involved in the transformation of FA dila

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7

Aragón-Gutiérrez, Alejandro, Estela Rosa, Miriam Gallur, Daniel López, Pilar Hernández-Muñoz, and Rafael Gavara. "Melt-Processed Bioactive EVOH Films Incorporated with Ferulic Acid." Polymers 13, no. 1 (2020): 68. http://dx.doi.org/10.3390/polym13010068.

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In this work, antimicrobial and antioxidant films based on ethylene vinyl alcohol (EVOH) copolymer containing low amounts of ferulic acid (FA) were successfully developed by melt extrusion. Optically transparent films were obtained, and the presence of FA provided some UV blocking effect. The characterization of the thermal and barrier properties of the developed films showed that the addition of FA improved the thermal stability, decreased the glass transition temperature (Tg) and increased the water vapor and oxygen transmission rates when ferulic acid was loaded above 0.5 wt.%, associated w

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8

Lee, Sheng-Chi, Chin-Chuan Tsai, Chun-Hsu Yao, Yueh-Sheng Chen, and Ming-Chang Wu. "Ferulic Acid Enhances Peripheral Nerve Regeneration across Long Gaps." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/876327.

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This study investigated the effect of ferulic acid (FA) on peripheral nerve injury. In thein vitrotest, the effect of FA on viability of Schwann cells was studied. In thein vivotest, right sciatic nerves of the rats were transected, and a 15 mm nerve defect was created. A nerve conduit made of silicone rubber tube filled with FA (5 and 25 μg/mL), or saline (control), was implanted into the nerve defect. Results show that the number of proliferating Schwann cells increased significantly in the FA-treated group at 25 μg/mL compared to that in the control group. After 8 weeks, the FA-treated grou

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9

Yu, Deng Guang, Wei Qian, Xia Wang, Ying Li, Wei Jun Lu, and Yong Zhang. "Ferulic Acid-Loaded Shellac Microparticles Prepared Using Electrohydrodynamic Atomization." Advanced Materials Research 675 (March 2013): 326–30. http://dx.doi.org/10.4028/www.scientific.net/amr.675.326.

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An Electrohydrodynamic atomization (EHDA) process was exploited to prepare ferulic acid (FA)-loaded shellac microparticles. SEM observations showed that all the particles were round and solid with their sizes gradually increased from 0.68 ± 0.21 to 2.75 ± 0.64 μm as the concentrations of shellac and FA in ethanol raised from 20% to 50% (w/v). Wide-angle X-ray diffraction analyses demonstrated that FA had been totally converted into an amorphous state in the shellac matrix microparticles. Attenuated total reflectance Fourier transform infrared analysis disclosed that the hydrogen bonding presen

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10

Grimaudo, Maria Aurora, Angel Concheiro, and Carmen Alvarez-Lorenzo. "Crosslinked Hyaluronan Electrospun Nanofibers for Ferulic Acid Ocular Delivery." Pharmaceutics 12, no. 3 (2020): 274. http://dx.doi.org/10.3390/pharmaceutics12030274.

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Electrospun nanofibers are gaining interest as ocular drug delivery platforms that may adapt to the eye surface and provide sustained release. The aim of this work was to design an innovative ophthalmic insert composed of hyaluronan (HA) nanofibers for the dual delivery of an antioxidant (ferulic acid, FA) and an antimicrobial peptide (ε-polylysine, ε-PL). Polyvinylpyrrolidone (PVP) was added to facilitate the electrospinning process. Fibers with diameters of approx. 100 nm were obtained with PVP 5%-HA 0.8% w/v and PVP 10%-HA 0.5% w/v mixtures in ethanol:water 4:6 v/v. An increase in PVP conce

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11

Cappelli, A., G. Grisci, M. Paolino, et al. "Hyaluronan derivatives bearing variable densities of ferulic acid residues." J. Mater. Chem. B 2, no. 28 (2014): 4489–99. http://dx.doi.org/10.1039/c3tb21824d.

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12

Adefegha, Stephen A., Olasunkanmi S. Omojokun, Ganiyu Oboh, Olasunkanmi Fasakin, and Opeyemi Ogunsuyi. "Modulatory Effects of Ferulic Acid on Cadmium-Induced Brain Damage." Journal of Evidence-Based Complementary & Alternative Medicine 21, no. 4 (2016): NP56—NP61. http://dx.doi.org/10.1177/2156587215621726.

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Studies have shown the pharmacological relevance of phenolics like ferulic acid (FA) in promoting health. This study sought to investigate the modulatory effects of FA on cadmium-induced brain damage in rats. Brain damage was induced in Wistar strain rats by oral administration of cadmium (5 mg/kg body weight) for 21 days. Assays for malondialdehyde (MDA) content, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), and Na+/K+-ATPase activities were carried out. The study revealed significant ( P < .05) increases in the MDA content and all enzymes’ (AChE, BChE

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13

Gao, Baojiao, Suqing Meng, and Liqin Zhang. "Designing and preparation of ferulic acid surface-imprinted material and its molecular recognition characteristics." RSC Advances 6, no. 5 (2016): 3986–96. http://dx.doi.org/10.1039/c5ra21725c.

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14

Girsang, Ermi, I. Nyoman Ehrich Lister, Chrismis Novalinda Ginting, Maulidwina Bethasari, Annisa Amalia, and Wahyu Widowati. "Comparison of Antiaging and Antioxidant Activities of Protocatechuic and Ferulic Acids." Molecular and Cellular Biomedical Sciences 4, no. 2 (2020): 68. http://dx.doi.org/10.21705/mcbs.v4i2.90.

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Background: Skin-aging is a progressive changes in the skin combine with cumulative extrinsic factors which are mostly caused by free radicals caused by exposure to lots of free radicals molecules from pollutant, wrongly food intake, or too much sun bathing. These free radicals can be tackled by a treatment using antioxidants. Prevention of aging can be done by escalating antioxidant intake. Protocatechuic acid (PCA) and Ferulic acid (FA) have been known for their scavenging properties on free radicals and antiaging activity. Antioxidant and antiaging activity of both compounds have not been c

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15

Nakayama, Hironao, Masako Nakahara, Erina Matsugi, et al. "Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells." Molecules 26, no. 1 (2020): 90. http://dx.doi.org/10.3390/molecules26010090.

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Ferulic Acid (FA) is a highly abundant phenolic phytochemical which is present in plant tissues. FA has biological effects on physiological and pathological processes due to its anti-apoptotic and anti-oxidative properties, however, the detailed mechanism(s) of function is poorly understood. We have identified FA as a molecule that inhibits apoptosis induced by hydrogen peroxide (H2O2) or actinomycin D (ActD) in rat pheochromocytoma, PC12 cell. We also found that FA reduces H2O2-induced reactive oxygen species (ROS) production in PC12 cell, thereby acting as an anti-oxidant. Then, we analyzed

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16

Wang, Yu, Yuzhen Wang, and Huilin Liu. "A Novel Fluorescence and SPE Adsorption Nanomaterials of Molecularly Imprinted Polymers Based on Quantum Dot-Grafted Covalent Organic Frameworks for the High Selectivity and Sensitivity Detection of Ferulic Acid." Nanomaterials 9, no. 2 (2019): 305. http://dx.doi.org/10.3390/nano9020305.

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A fluorescence and solid phase extraction (SPE) adsorption nanomaterials of molecularly imprinted polymers (MIPs) based on quantum dot-grafted covalent organic frameworks (QD-grafted COFs) was prepared by one-pot surface-imprinting synthesis method. Amino groups of silane reagent were at the surface of QDs to coordinate COFs efficiently by Schiff-base reactions, providing thermal and chemical stability to MIPs. It also reacted with the phenolic hydroxyl groups of ferulic acid (FA) through non-covalent interactions. The nanomaterials were used as fluorescence sensing and SPE adsorption toward d

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17

David, Iulia Gabriela, Laura Andreea Iordache, Mihaela Carmen Cheregi, Dana Elena Popa, and Mihaela Buleandră. "Electrochemical Study of Ferulic Acid at a Pencil Graphite Electrode." Proceedings 57, no. 1 (2020): 56. http://dx.doi.org/10.3390/proceedings2020057056.

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Ferulic acid (FA), a hydroxycinnamic acid naturally found in fruits, vegetables and alcoholic beverages, has antioxidant, antiaging, antiviral and antibacterial activity being used in the medicine, food and pharmaceutical industries [1]. [...]

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18

Wang, Youxia, Xiaoling Chen, Zhiqing Huang, et al. "Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets." Nutrients 12, no. 12 (2020): 3811. http://dx.doi.org/10.3390/nu12123811.

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Ferulic acid (FA) is a phenolic compound that has antioxidant, hepatoprotective, anticarcinogenic, anti-inflammatory, antiallergic, antimicrobial, antiviral, and vasodilatory effects. This study was conducted to explore the effects of dietary FA supplementation on antioxidant capacity and lipid metabolism in weaned piglets. Eighteen 21-day-old castrated male DLY (Duroc × Landrace × Yorkshire) weaned piglets were randomly divided into control, 0.05%, and 0.45% FA groups. The results showed that, in serum, CAT and T-SOD activities and content of HDL-C were increased, but the content of MDA and t

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19

Peng, Chiung-Chi, Charng-Cherng Chyau, Hui-Er Wang, et al. "Cytotoxicity of Ferulic Acid on T24 Cell Line Differentiated by Different Microenvironments." BioMed Research International 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/579859.

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Ferulic acid (4-hydroxy-3-methoxycinnamic acid) (FA) is a ubiquitous health beneficial phenolic acid. Although FA has shown a diversity of biological activities including anti-inflammatory, antihypercholesterolemic and anticancer bioactivities, studies revealing its adverse effects are accumulating. Recently, 3D-cultures are shown to exhibit uniquely biological behaviors different from that of 2D cultures. To understand whether the cytotoxicity of FA against the T24 cell line (a bladder cancer cell line) in 2D-culture could consistently retain similar bioactivity if cultured in the 3D-systems,

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20

Lambruschini, Chiara, Ilaria Demori, Zeinab El Rashed, et al. "Synthesis, Photoisomerization, Antioxidant Activity, and Lipid-Lowering Effect of Ferulic Acid and Feruloyl Amides." Molecules 26, no. 1 (2020): 89. http://dx.doi.org/10.3390/molecules26010089.

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The Ugi four-component reaction employing naturally occurred ferulic acid (FA) is proposed as a convenient method to synthesize feruloyl tertiary amides. Applying this strategy, a peptoid-like derivative of ferulic acid (FEF77) containing 2 additional hydroxy-substituted aryl groups, has been synthesized. The influence of the configuration of the double bond of ferulic acid and feruloyl amide on the antioxidant activity has been investigated thanks to light-mediated isomerization studies. At the cellular level, both FA, trans and cis isomers of FEF77 were able to protect human endothelial cord

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21

Wu, Yu, Yu-gang Shi, Xiao-liang Zheng та ін. "Lipophilic ferulic acid derivatives protect PC12 cells against oxidative damage via modulating β-amyloid aggregation and activating Nrf2 enzymes". Food & Function 11, № 5 (2020): 4707–18. http://dx.doi.org/10.1039/d0fo00800a.

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22

Numpaque, Manuel Alejandro, Jesús Humberto Gil González, and Diego Luis Durango Restrepo. "Biotransformation of ferulic acid by the phytopathogenic fungi Colletotrichum acutatum and Lasiodiplodia theobromae." Revista Facultad Nacional de Agronomía Medellín 69, no. 1 (2016): 7835–44. http://dx.doi.org/10.15446/rfna.v69n1.54751.

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The microbial transformation of ferulic acid (FA) offers a cleaner, more economical alternative for the natural production of flavorings and fragrances. In the present study, the biotransformation of FA using the filamentous phytopathogenic fungi Colletotrichum acutatum and Lasiodiplodia theobromae was researched. Initially, the toxicity of FA against both fungi was evaluated; the FA displayed a moderate toxicity (total inhibition at concentrations ≥ 2000 mg L-1) and apparently a detoxification mechanism was present. Afterwards, the microorganisms were incubated with the substrate at room cond

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23

Valcheva-Kuzmanova, Stefka, Antoaneta B. Georgieva, Stiliana P. Belcheva, and Roman E. Tashev. "Effects Of Ferulic Acid On Exploratory Behavior And Locomotor Activity In Rats." Journal of Biomedical and Clinical Research 7, no. 2 (2014): 81–87. http://dx.doi.org/10.1515/jbcr-2015-0130.

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Summary Ferulic acid (FA), called also hydroxycinnamic acid, is a polyphenol compound found in many foods such as coffee, apples, rice, oats and wheat. It acts as an antioxidant but its other activities in vivo have not been well studied as a whole. The aim of the present study was to investigate the effects of FA on exploratory behavior and locomotor activity in male Wistar rats. FA was administrated orally (20 mg/kg) to different groups of rats for 7, 14, 21 and 30 days. These groups were compared respectively with saline-treated controls. At the end of each experimental period, the changes

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Song, Yafan, Chunyan Zhang, Congxia Wang та ін. "Ferulic Acid against Cyclophosphamide-Induced Heart Toxicity in Mice by Inhibiting NF-κB Pathway". Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/1261270.

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The purpose of the present study was to elucidate the protective effects of ferulic acid (FA) against cyclophosphamide- (CTX-) induced changes in mice. Forty-eight male ICR mice were divided into four groups. Control group was intraperitoneally (i.p.) injected with 200 μL of phosphate buffer saline (PBS). Model group was intraperitoneally injected with a single dose of CTX (200 mg/kg). FA (50 mg/kg) and FA (100 mg/kg) groups were intraperitoneally injected with a single dose of CTX (200 mg/kg) followed by the intragastric treatment with FA (50, 100 mg/kg) for 7 consecutive days. After 12 d, th

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25

Serreli, Gabriele, Micaela Rita Naitza, Sonia Zodio, et al. "Ferulic Acid Metabolites Attenuate LPS-Induced Inflammatory Response in Enterocyte-like Cells." Nutrients 13, no. 9 (2021): 3152. http://dx.doi.org/10.3390/nu13093152.

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Ferulic acid (FA) is a polyphenol pertaining to the class of hydroxycinnamic acids present in numerous foods of a plant origin. Its dietary consumption leads to the formation of several phase I and II metabolites in vivo, which represent the largest amount of ferulates in the circulation and in the intestine in comparison with FA itself. In this work, we evaluated their efficacy against the proinflammatory effects induced by lipopolysaccharide (LPS) in intestinal Caco-2 cell monolayers, as well as the mechanisms underlying their protective action. LPS-induced overexpression of proinflammatory

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26

Liu, Lin-jie, Xia Gao, Pei Zhang, et al. "Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor." Journal of Analytical Methods in Chemistry 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/424790.

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The electrochemical redox of ferulic acid (FA) was investigated systematically by cyclic voltammetry (CV) with a poly(diallyldimethylammonium chloride) functionalized graphene-modified glassy carbon electrode (PDDA-G/GCE) as a working electrode. A simple and sensitive differential pulse voltammetry (DPV) technique was proposed for the direct quantitative determination of FA inAngelica sinensisand spiked human urine samples for the first time. The dependence of the intensities of currents and potentials on nature of the supporting electrolyte, pH, scan rate, and concentration was investigated.

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Salamanova, Evdokiya, Mariyana Atanasova, Ivan Dimitrov та Irini Doytchinova. "Effects of Curcumin and Ferulic Acid on the Folding of Amyloid-β Peptide". Molecules 26, № 9 (2021): 2815. http://dx.doi.org/10.3390/molecules26092815.

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The polyphenols curcumin (CU) and ferulic acid (FA) are able to inhibit the aggregation of amyloid-β (Aβ) peptide with different strengths. CU is a strong inhibitor while FA is a weaker one. In the present study, we examine the effects of CU and FA on the folding process of an Aβ monomer by 1 µs molecular dynamics (MD) simulations. We found that both inhibitors increase the helical propensity and decrease the non-helical propensity of Aβ peptide. They prevent the formation of a dense bulk core and shorten the average lifetime of intramolecular hydrogen bonds in Aβ. CU makes more and longer-liv

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Zhang, Chao, Xiao Fei Guo, Yue Ma, and Xiao Yan Zhao. "Ferulic Acid and its Oxide Enhance Performance of Soy Protein-Isolate/Chitosan Composite Films." Applied Mechanics and Materials 716-717 (December 2014): 28–31. http://dx.doi.org/10.4028/www.scientific.net/amm.716-717.28.

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The effect of FA and OFA on performances of the soybean protein-isolate/chitosan composite films was evaluated. The FA and OFA enhanced the tensile strength and thermal stability of the composite films significantly, while they reduced the water vapor permeability to 60.3 % and 72.8 % of the control respectively. Moreover, the OFA was more effective to enhance the tensile strength of the composite films than the FA.

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29

Parisi, Ortensia Ilaria, Daniela Aiello, Maria Francesca Casula, et al. "Mesoporous nanocrystalline TiO2 loaded with ferulic acid for sunscreen and photo-protection: safety and efficacy assessment." RSC Advances 6, no. 87 (2016): 83767–75. http://dx.doi.org/10.1039/c6ra07653j.

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In the present study, the use of surfactant-free mesoporous TiO<sub>2</sub> combined with an antioxidant and photo-protecting agent, such as ferulic acid (FA), as a sunscreen was investigated for the first time.

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Li, Hui, Xiaoxuan Yu, Fanwei Meng, Zhenyu Zhao, Shuwen Guan, and Liping Wang. "Ferulic Acid Supplementation Increases Lifespan and Stress Resistance via Insulin/IGF-1 Signaling Pathway in C. elegans." International Journal of Molecular Sciences 22, no. 8 (2021): 4279. http://dx.doi.org/10.3390/ijms22084279.

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Ferulic acid (FA) is a naturally-occurring well-known potent antioxidant and free radical scavenger. FA supplementation is an effective strategy to delay aging, but the underlying mechanism remains unknown. In the present study, we examined the effects of FA on lifespan extension and its mechanism of FA in Caenorhabditis elegans (C. elegans). Results suggested that FA increased the lifespan of C. elegans, rather than altering the growth of E. coli OP50. Meanwhile, FA promoted the healthspan of C. elegans by improving locomotion and reducing fat accumulation and polyQ aggregation. FA increased

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Stobiecki, Maciej, Maciej Buśko, Łukasz Marczak, Paweł Bednarek, Mariola Piślewska, and Przemysław Wojtaszek. "The complexity of oxidative cross-linking of phenylpropanoids — evidence from an in vitro model system." Functional Plant Biology 29, no. 7 (2002): 853. http://dx.doi.org/10.1071/pp01233.

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The development of an in vitro model system to study the process of dimerization of hydroxycinnamic acids is reported. Model compounds ferulic acid (FA) or methyl ferulate were reacted with H2O2 in the presence of horseradish peroxidase (HRP) or peroxidases from Lupinus albus L. apoplastic fluids. Following solid-phase extraction, the reaction products were analysed using gas chromatography-mass spectrometry. Major analytical and biochemical parameters of model reactions were determined and optimized. Six ferulic dimers were identified and quantified. With the use of this model system we found

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Kuppusamy, Palaniselvam, Soundharrajan Ilavenil, In Ho Hwang, Dahye Kim, and Ki Choon Choi. "Ferulic Acid Stimulates Adipocyte-Specific Secretory Proteins to Regulate Adipose Homeostasis in 3T3-L1 Adipocytes." Molecules 26, no. 7 (2021): 1984. http://dx.doi.org/10.3390/molecules26071984.

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Obesity has recently emerged as a public health issue facing developing countries in the world. It is caused by the accumulation of fat in adipose, characterized by insulin resistance, excessive lipid accumulation, inflammation, and oxidative stress, leading to an increase in adipokine levels. Herein, we investigated the capacity of a bioactive polyphenolic compound (ferulic acid (FA)) to control adipocyte dysfunction in 3T3-L1 adipocytes (in vitro). Key adipocyte differentiation markers, glycerol content, lipolysis-associated mRNA, and proteins were measured in experimental adipocytes. FA-tre

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Zhang, Peng-Xuan, Hang Lin, Cheng Qu, et al. "Design, Synthesis, andIn VitroAntiplatelet Aggregation Activities of Ferulic Acid Derivatives." Journal of Chemistry 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/376527.

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In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. Thein vitroantiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound7fhad potent antiplatelet aggregation activity with its IC5027.6 μmol/L, and7fcan be regarded as a novel potent antiplatelet aggregation candidate.

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Wong, Dominic W. S., Victor J. Chan, and Hans Liao. "Hydrolysis of ferulic acids in corn fiber by a metagenomic feruloyl esterase." BioResources 16, no. 1 (2020): 825–34. http://dx.doi.org/10.15376/biores.16.1.825-834.

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A feruloyl esterase (FAE) gene was isolated from rumen microbial metagenome that consisted of 774 bp encoding 258 amino acid residues. The gene was subcloned into pET 32b vector, expressed in Escherichia. coli, and the enzyme was purified in active form. Homology modeling showed that the FAE contained the catalytic triad composed of Ser80-His236-Asp177, and a classical Gly-X-Ser-X-Gly nucleophile motif commonly found in esterases. Under optimum pH and temperature (pH 7.0, 40 °C), 1 nmole FAE catalyzed the release of 19.75 ± 0.24 µg ferulic acid (FA) from 100 mg corn fiber (CF) in 1 h, which re

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35

Cheng, Chao-Wen, Wen-Liang Chang, Li-Cheng Chang, Chia-Chao Wu, Yuh-Feng Lin, and Jin-Shuen Chen. "Ferulic Acid, anAngelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/161235.

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Membranous nephropathy (MN) is a leading cause of adult nephrotic syndrome but lacks adequate treatment. Different extracts ofAngelica sinensis(AS) and one of its active compounds, ferulic acid (FA), were used to evaluate the therapeutic effects in a MN mouse model. The MN model was grouped into three subgroups: no treatment (N-T), treatment at induction of MN (Pre-T), and treatment after full-blown MN (Post-T). The results showed that the methanol (ME) layer of AS extract exhibited a therapeutic effect on MN-induced proteinuria. The ME layer-enriched compound, FA, improved the hypoalbuminemia

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He, Liming, Yingchun Zeng, Xianyan Qin, et al. "Delivery of Ferulic Acid with PEGylated DiphenylalanineBased Nanoparticles for the Treatment of Arthritis in Early Stage." Journal of Biomedical Nanotechnology 17, no. 3 (2021): 357–68. http://dx.doi.org/10.1166/jbn.2021.3022.

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Ferulic acid (FA), an active component extracted from Chinese medicine, shows excellent anti-inflammatory properties and favorable safety in various animal models. However, the application of FA as an anti-inflammatory drug is hindered by its instability and short half-life in vivo . In this paper, we synthesize PEGylated diphenylalanine nanoparticles by using glutaraldehyde (GTA) as a cross-linker of diphenylalanine NH2 -Phe–Phe-COOH and poly(ethylene glycol) methyl ether amine (PEG5k -NH2). The PEGylated Phe–Phe nanoparticles are used to deliver FA for the treatment of Rheumatoid arthritis (

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Reddy, Bandugula, and N. Prasad. "2-deoxy-D-glucose combined with ferulic acid enhances radiation response in non-small cell lung carcinoma cells." Open Life Sciences 6, no. 5 (2011): 743–55. http://dx.doi.org/10.2478/s11535-011-0038-4.

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AbstractThe present study was undertaken to investigate the radiosensitizing effects of 2-deoxy-D-glucose (2DG), a glycolytic inhibitor, and ferulic acid (FA), a phenolic prooxidant, in relatively radioresistant human non-small cell lung carcinoma cells (NCI-H460). NCI-H460 cells were treated with 4 mM 2DG and/or 53.8 µM FA for 24 h and then exposed to 2 Gy irradiation. Compared to cells that were 2 Gy-irradiated alone (50%), FA and 2DG with radiation (FA+2DG+IR) showed additional decrease in cell viability (15%). This has been further validated by decreased (86%) colony formation in 2DG+FA+IR

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Narasimhan, Akilavalli, Mayilvanan Chinnaiyan, and Balasubramanian Karundevi. "Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat." Applied Physiology, Nutrition, and Metabolism 40, no. 8 (2015): 769–81. http://dx.doi.org/10.1139/apnm-2015-0002.

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Ferulic acid (FA) is a phenolic phytochemical known for its antidiabetic property The present study is designed to evaluate the mechanism behind its antidiabetic property in high-fat and fructose-induced type 2 diabetic adult male rats. Animals were divided into 5 groups: (i) control, (ii) diabetic control, (iii) diabetic animals treated with FA (50 mg/(kg body weight·day)–1, orally) for 30 days, (iv) diabetic animals treated with metformin (50 mg/(kg body weight·day)–1, orally) for 30 days, and (v) control rats treated with FA. FA treatment to diabetic animals restored blood glucose, serum in

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Das, Ujjal, Sushobhan Biswas, Aaveri Sengupta, Krishnendu Manna, Anindita Chakraborty, and Sanjit Dey. "Ferulic acid (FA) abrogates ionizing radiation-induced oxidative damage in murine spleen." International Journal of Radiation Biology 92, no. 12 (2016): 806–18. http://dx.doi.org/10.1080/09553002.2016.1230241.

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Kokumai, Takumi, Junya Ito, Eri Kobayashi та ін. "Comparison of Blood Profiles of γ-Oryzanol and Ferulic Acid in Rats after Oral Intake of γ-Oryzanol". Nutrients 11, № 5 (2019): 1174. http://dx.doi.org/10.3390/nu11051174.

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γ-Oryzanol (OZ), a bioactive phytochemical abundant in cereals such as rice, has been reported to be mainly hydrolyzed to ferulic acid (FA) in the body. Meanwhile, in our previous study, we revealed that a part of OZ is absorbed into the body and exists in its intact form. However, the comprehensive absorption profile of OZ and its metabolites (e.g., FA) after OZ intake has not been fully elucidated yet. Therefore, in this study, we measured the concentrations of OZ, FA, and FA conjugates (i.e., FA sulfate and glucuronide) in the blood of rats with the use of HPLC-MS/MS after a single oral adm

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Divakaran, Saratchandran A., and Anitha CT. "TREATMENT WITH FERULIC ACID AMELIORATED CISPLATIN‑INDUCED NEPHROTOXICITY AND OXIDATIVE STRESS IN TUMOR BEARING MICE." Journal of Experimental Biology and Agricultural Sciences 9, no. 4 (2021): 492–99. http://dx.doi.org/10.18006/2021.9(4).492.499.

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Cisplatin (Cis) is one of the most widely used cytotoxic therapeutic agents for the treatment of cancer. Overdose of the drug resulted in various side effects of genotoxicity and nephrotoxicity. The toxicity of the drug has been attributed to the generation of oxidative free radicals. The current study aims to explore the effect of Ferulic acid (FA) in ameliorating Cis-induced renal toxicity in tumor bearing Swiss albino mice. Nephrotoxicity was induced in tumor bearing mice by a single dose of Cis (12mg/kg, i.p). Post administration of FA was carried out (100 mg/kg p.o and 200 mg/kg p.o) one

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Borgohain, Romesh, Jyotirekha G. Handique, Ankur Kanti Guha, and Sanjay Pratihar. "A theoretical study on antioxidant activity of ferulic acid and its ester derivatives." Journal of Theoretical and Computational Chemistry 15, no. 04 (2016): 1650028. http://dx.doi.org/10.1142/s0219633616500280.

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Phenolic compounds play a very crucial role as antioxidant that can prevent various diseases caused by free radicals in human body. Although, lots of natural phenolic compounds having antioxidant activity are available nowadays, the modeling of compounds with naturally available phenolics as building blocks is very important in order to get enhanced antioxidant activity. In this study, Ferulic acid (FA), one natural phenolic acid present in coffee, apples, orange, etc., is taken as building block and its ester derivatives with different alkyl groups are subjected to measure the antioxidant act

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Wang, Zhihong, Ruiqing Long, Mijun Peng, Te Li, and Shuyun Shi. "Molecularly Imprinted Polymers-Coated CdTe Quantum Dots for Highly Sensitive and Selective Fluorescent Determination of Ferulic Acid." Journal of Analytical Methods in Chemistry 2019 (July 8, 2019): 1–8. http://dx.doi.org/10.1155/2019/1505878.

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Ferulic acid (FA), an important phenolic acid, is widely distributed in higher plants and presents many pharmacological effects. Therefore, sensitive determination of FA in complex matrix is necessary. Molecularly imprinted polymers-coated CdTe quantum dots (CdTe-QDs@MIPs) exhibited incomparable advantages because of their combination of excellent selectivity of MIPs and high sensitivity of QDs. Here, a fluorescent probe based on CdTe-QDs@MIPs was successfully fabricated for selective and sensitive determination of FA. MIPs shell was obtained by the reverse microemulsion method using FA, 3-(am

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Wang, Yuan, Wenwen Wang, Ruifang Wang, et al. "Dietary supplementation of ferulic acid improves performance and alleviates oxidative stress of lambs in a cold environment." Canadian Journal of Animal Science 99, no. 4 (2019): 705–12. http://dx.doi.org/10.1139/cjas-2018-0200.

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Ferulic acid (FA) has been regarded as an antioxidant in domestic animals’ feed. This study was to investigate whether dietary FA supplementation could improve growth performance by decreasing oxidative stress of lambs in cold environment. Thirty-two 3-mo-old crossbred male lambs (Dorper × Small-tail Han sheep; 30.49 ± 0.46 kg) were randomly assigned into one of the following dietary treatments: CON (control, no FA), FA80 (80 mg FA kg−1of diet), FA400 (400 mg FA kg−1of diet), and FA2000 (2000 mg FA kg−1of diet). Lambs fed the FA80 had higher (P < 0.05) average daily gain and lower (P < 0

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Suodkolae, Massoumeh, Teimouri Yansari, and Yadollah Chashnidel. "Effects of hydroxycinnamic acids (Ferulic and p-coumaric acids) in barley cultivars on cell wall components degradability in rumen." Biotehnologija u stocarstvu 33, no. 3 (2017): 271–89. http://dx.doi.org/10.2298/bah1703271s.

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Barley grain contains hydroxycinnamic acids especially Ferulic (FA) and p-Coumaric acid (pCA) become cross-linked to cell wall polysaccharids as lignification commences that are the major inhibiting factors of biodegradability of plant cell walls in the rumen. Chemical characteristics, FA and pCA content of 11 Iranian barley cultivars determined. Using 3 fistulated ewes, the effects of FA and pCA content on ruminal degradation of dry matter (DM), neutral and acid detergent fiber (NDF and ADF) and lignin were studied. In barley cultivars, DM varied from 82.52 to 90.90 %; NDF varied from 9.64 to

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Sharif, Niloufar, Mohammad-Taghi Golmakani, Mehrdad Niakousari, Seyed Hosseini, Behrouz Ghorani, and Amparo Lopez-Rubio. "Active Food Packaging Coatings Based on Hybrid Electrospun Gliadin Nanofibers Containing Ferulic Acid/Hydroxypropyl-Beta-Cyclodextrin Inclusion Complexes." Nanomaterials 8, no. 11 (2018): 919. http://dx.doi.org/10.3390/nano8110919.

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In this work, hybrid gliadin electrospun fibers containing inclusion complexes of ferulic acid (FA) with hydroxypropyl-beta-cyclodextrins (FA/HP-β-CD-IC) were prepared as a strategy to increase the stability and solubility of the antioxidant FA. Inclusion complex formation between FA and HP-β-CD was confirmed by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), and X-ray diffraction (XRD). After adjusting the electrospinning conditions, beaded-free fibers of gliadin incorporating FA/HP-β-CD-IC with average fiber diameters ranging from 269.91 ± 73.53 to 27

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Valenzuela-Grijalva, Nidia, Ismael Jiménez-Estrada, Silvia Mariscal-Tovar, et al. "Effects of Ferulic Acid Supplementation on Growth Performance, Carcass Traits and Histochemical Characteristics of Muscle Fibers in Finishing Pigs." Animals 11, no. 8 (2021): 2455. http://dx.doi.org/10.3390/ani11082455.

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FA dietary supplementation on the growth performance, carcass traits and histochemical characteristics of the Longissimus thoracis muscle from finishing pigs was investigated. Four hundred and twenty pigs were used in this study, and 105 animals (with five replicate pens and 21 pigs per pen) were assigned to one of four treatments: basal diet (BD) without additives (C−); BD + 10 ppm ractopamine hydrochloride + 0.97% lysine (C+); BD + 25 ppm of FA (FA); and BD + 25 ppm of FA + 0.97% lysine (FA-Lys). Dietary supplementation with FA or ractopamine increased both the average daily gain (14%) and l

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Chao, HM, YH Chen, JH Liu, et al. "Iron-generated hydroxyl radicals kill retinal cells in vivo: effect of ferulic acid." Human & Experimental Toxicology 27, no. 4 (2008): 327–39. http://dx.doi.org/10.1177/0960327108092294.

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Siderosis bulbi is vision threatening. An investigation into its mechanisms and management is crucial. Experimental siderosis was established by intravitreous administration of an iron particle (chronic) or FeSO4 (acute). After siderosis, there was a significant dose-responsive reduction in eletroretinogram (a/b-wave) amplitude, and an increase in •OH level, greater when caused by 24 mM FeSO4 than that by 8 mM FeSO4. Furthermore, the FeSO4-induced oxidative stress was significantly blunted by 100 μM ferulic acid (FA). Siderosis also resulted in an excessive glutamate release, increased [Ca++]i

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Zhu, Hao, Qing-Hua Liang, Xin-Gui Xiong, et al. "Anti-Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained inOldenlandia diffusaon Collagen-Induced Arthritis in Rats." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/573801.

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Objectives. This study aimed to identify the active compounds inOldenlandia diffusa(OD) decoction and the compounds absorbed into plasma, and to determine whether the absorbed compounds derived from OD exerted any anti-inflammatory effects in rats with collagen induced arthritis (CIA).Methods. The UPLC-PDA (Ultra Performance Liquid Chromatography Photo-Diode Array) method was applied to identify the active compounds both in the decoction and rat plasma. The absorbable compound was administered to the CIA rats, and the effects were dynamically observed. X-ray films of the joints and HE stain of

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Nastasiienko, Nataliia, Tetiana Kulik, Borys Palianytsia, et al. "Catalytic Pyrolysis of Lignin Model Compounds (Pyrocatechol, Guaiacol, Vanillic and Ferulic Acids) over Nanoceria Catalyst for Biomass Conversion." Applied Sciences 11, no. 16 (2021): 7205. http://dx.doi.org/10.3390/app11167205.

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Understanding the mechanisms of thermal transformations of model lignin compounds (MLC) over nanoscale catalysts is important for improving the technologic processes occurring in the pyrolytic conversion of lignocellulose biomass into biofuels and value-added chemicals. Herein, we investigate catalytic pyrolysis of MLC (pyrocatechol (P), guaiacol (G), ferulic (FA), and vanillic acids (VA)) over nanoceria using FT-IR spectroscopy, temperature-programmed desorption mass spectrometry (TPD MS), and thermogravimetric analysis (DTG/DTA/TG). FT-IR spectroscopic studies indicate that the active groups

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