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Dissertations / Theses on the topic 'Fetal cell'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Götherström, Cecilia. "Characterisation of human fetal mesenchymal stem cells /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-139-3/.

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2

Weinhaus, Anthony James. "Physiology of the fetal B-cell." Thesis, The University of Sydney, 1994. https://hdl.handle.net/2123/26826.

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The use of islets isolated from the human fetal pancreas may provide a source of transplantable tissue with the potential to reverse diabetes. Further research is required before there is enough knowledge of the function of these islets to enable their successful transplantation to humans. Chapter 1 Experiments on fetal pancreas are limited by the paucity and irregularity of the supply of donor tissue. Therefore, a human fetal pancreatic B—cell line would be of considerable use in the better understanding of this potential source of transplantable tissue. In chapter 1 of this thesis, succe

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3

Cowan, Gillian. "Fetal germ cell differentiation and the impact of the somatic cells." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4164.

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Specification of a germ cell lineage and appropriate maturation are essential for the transfer of genetic information from one generation to the next. Germ cells form from pluripotent precursor cells that migrate into the gonadal ridge and undergo commitment to either the female or male lineage. In the fetal ovary, germ cells enter meiotic prophase I, then arrest at the diplotene stage; in the testis germ cells do not begin meiosis until puberty. Abnormal differentiation of germ cells can result in malignant transformation. Somatic cells play a key role in modulating the developmental fate of

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4

Li, Qinggang. "In vitro regulation of fetal bovine erythropoiesis." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42078.

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Fetal bovine serum (FBS) is one of the most important supplements for cell culture, and is a rich source of both defined and unknown factors required for proper cell growth. A serum-free bioassay system was developed to facilitate the purification and characterization of the heparin-binding growth factors in FBS. Three factors with different effects on erythropoiesis were isolated and identified with the combination of several chromatographic techniques. An 8 kd heparin-binding peptide which stimulated thymidine incorporation into fetal erythroid cells had an N-terminal sequence identical to i

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5

Saleh, A. W. "Modulation of fetal hemoglobin in sickle cell anemia." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8498.

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6

Maciaczyk, Jaroslaw. "Human fetal neural precursor cells: a putative cell source for neurorestorative strategies." [S.l. : s.n.], 2005. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-57885.

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7

Ditadi, Andrea. "Cell therapy approach for hematopoietic diseases using fetal cells issued from amniotic fluid." Paris 5, 2008. http://www.theses.fr/2008PA05T036.

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Dans la présente étude, nous avons étudié la possibilité de différencier les cellules souches du liquide amniotique humain (hAFSC) et murin (mAFSC) vers la voie hématopoïétique à la fois in vitro et in vivo. Nous avons de manière reproductible réalisé une différenciation érythroïde par culture des hAFSCs en corps embryoïdes (EB). Plus de 70% des cellules constituant les EB coexprimaient des marqueurs erythroïdes. De plus, 3 mois après l'injection de hAFSC à des souris NOD/SCID irradiées, nous avons pu détecter dans la rate et la moelle osseuse des receveurs des érythrocytes humains. Nous avons

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8

Huygens, Ariane. "Fetal T cell response to human congenital cytomegalovirus infection." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209450.

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Les nouveau-nés et les jeunes enfants ont une susceptibilité plus élevée aux infections par rapport aux enfants plus âgés et aux adultes. Cette caractéristique est en partie attribuée à l’immaturité de leur système immunitaire qui est associée à une capacité limitée à développer des réponses immunitaires à médiation cellulaire. L’infection par le cytomégalovirus (HCMV) est la cause la plus fréquente d’infection congénitale chez l’Homme et une cause majeure de surdité et de retard mental. En Belgique, le dépistage anténatal de l’infection primaire par le HCMV chez les femmes enceintes offre l’o

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9

Schneidereith, Tonya A. "The pharmacogenetics of fetal hemoglobin and f-cell variation." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/308076.

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10

Ferreira, Leonardo. "Transcriptional Control of Maternal-Fetal Immune Tolerance." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493333.

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Human leukocyte antigens (HLA) are important determinants of self-nonself immune recognition. HLA-G, uniquely expressed in the placenta, is believed to be key to fetus-induced immune tolerance during pregnancy. The tissue-specific expression of HLA-G, however, remains poorly understood. Using a Massively Parallel Reporter Assay (MPRA), we discovered a 121 bp sequence 12 kb upstream of HLA-G with enhancer activity, Enhancer L. Strikingly, deletion of Enhancer L using a CRISPR/Cas9 dual guide approach resulted in complete ablation of HLA-G expression in a trophoblast cell line. This finding was

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11

Wu, Pensée. "Muscular dystrophy cell therapy : an in utero approach using human fetal mesenchymal stem cells." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/4726.

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Duchenne muscular dystrophy (DMD) is the most prevalent genetic neuromuscular disorder and affects 1 in 3,500 live male births. Lack of the protein dystrophin in muscle fibres causes permanent muscle damage, is lethal and despite various potential therapeutic strategies aimed at restoring dystrophin expression, has no cure. As DMD affects all skeletal muscles as well as the heart, a systemic treatment would be necessary and in utero stem cell transplantation is a promising way of achieving this. The identification of human fetal mesenchymal stem cells (hfMSC) in early gestation fetal blood off

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12

Jones, Gemma Nicole. "The potential of fetal cell therapy for osteogenesis imperfecta using placenta derived stem cells." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/40291.

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Human mesenchymal stromal/stem cells (MSC) isolated from aborted first trimester fetal bone marrow (BM) hold promise for use in tissue engineering applications and cell-based therapies due to their advantageous characteristics compared to their adult BM-MSC counterparts; faster growth kinetics, active telomerase, smaller size and higher differentiation potency. However, their isolation is restricted ethically and technically and therefore there is a need to identify a cell source with high therapeutic potential that is easily accessible in the clinic without ethical restrictions. The placenta

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13

Düber, Sandra. "B-cell development in fetal liver and adult bone marrow." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973900164.

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14

Kosmin, Alan Simon. "Cell proliferation, apoptosis and migration within the human fetal retina." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366488.

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15

DOFFINI, ANNA. "A cell-based NIPD (Non-invasive prenatal diagnosis) procedure to select fetal cells from pregnant women maternal blood." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/365173.

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Attualmente i metodi di diagnosi prenatale esistenti, consentono di ottenere cellule fetali solamente mediante metodiche invasive che comportano un rischio sia per la madre che per il feto. La scoperta nel 1979 della presenza di cellule fetali circolanti nel sangue materno, ha aperto la strada per lo sviluppo di metodi non invasivi per l’identificazione di anomalie fetali. Tutti i metodi sviluppati fino ad oggi tuttavia sono risultati inefficienti nel garantire un adeguato numero di cellule fetali, essendo estremamente laboriosi, richiedendo molto tempo ed essendo operatori-dipendenti. Questo

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16

Porada, Christopher Daniel. "In vivo gene transfer into fetal animals /." abstract and full text PDF (UNR users only), 1998. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:9833366.

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17

Carney, Rosalind S. E. "Thalamocortical development and cell proliferation in fetal primate and rodent cortex." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418812.

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18

Attilakos, Georgios. "Study of Cell-Free Fetal DNA in Multiple and Complicated Pregnancies." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521087.

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19

Macko, Antoni Ryszard. "Elevated Fetal Plasma Norepinephrine Elicits Perinatal Adaptations in β-Cell Function". Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/311460.

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The objective of this dissertation research was to determine the specific actions of chronically elevated catecholamines on; 1.) fetal growth and ß-cell function during the third trimester in vivo in an ovine model of placental insufficiency-induced intrauterine growth restriction (PI-IUGR), and 2.) regulation of insulin secretion in vitro utilizing the mouse insulinoma cell line Min6.At 0.7-gestation, fetal weights were not different but PI fetuses had lower (P<0.05) basal blood oxygen content, plasma glucose, IGF-1, and insulin concentrations and greater norepinephrine concentrations (891±21

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20

Mari, Chiara. "Generation and characterisation of progenitor cell lines from human fetal kidneys." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10050589/.

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Kidney disease is a global public health burden. Chronic kidney disease, with an incidence increasing annually in the Western world, is a progressive kidney damage that can lead to end-stage renal failure (CKD5), in which kidney function is completely lost. CKD5 treatment options are dialysis, which is not a cure for kidney disease and kidney transplantation limited by the shortage of donor organs. Kidney disease new interventions have two aims: 1. preventing the progression to CKD5 2. creating a healthy organ in vitro with bioengineered scaffolds in order to permanently replace defective kidn

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21

Aguiar, Bruna Andrade. "Obtenção e caracterização de células derivadas do pâncreas fetal canino." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-07102016-120231/.

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A Diabetes mellitus em cães é cada vez mais frequente, decorrente de fatores genéticos e/ou ambientais, como um distúrbio endócrino que, de forma semelhante à que ocorre em humanos, falha no controle adequado de glicose no sangue, desencadeia a hiperglicemia, glicosúria e perda de peso. A terapia celular utilizando as células beta-pancreáticas tem sido alvo de estudos, devido à grande demanda de novos casos de Diabetes mellitus e à falta de órgãos para transplantes em humanos e animais. Acredita-se que a ciência possa responder e inovar em tratamentos, encontrando a possível cura para esta doe

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22

Lindton, Bim. "Experimental studies of human fetal liver cells : in regard to in utero hematopoietic stem cell transplantation /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-134-9.

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23

Lo, Yuk-Ming Dennis. "Molecular analysis of non-host cell-free DNA in human plasma and serum." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365878.

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24

Myers, Kazimer Rene. "Correlation of membrane glycoconjugates and cell growth with the sensitivity of human glioma and fetal brain cells to natural killer cell cytolysis /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487670346874684.

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25

James-Allan, Laura B. "Decidual stromal cell regulation of the maternal-fetal interface in early pregnancy." Thesis, St George's, University of London, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.719155.

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Decidualisation is the differentiation of endometrial stromal cells in to specialised secretory decidual stromal cells (DSC), which commences in the mid-secretory phase of the menstrual cycle and continues in pregnancy. During placentation, DSC regulate and control the invasion of extravillous trophoblast cells (EVT). In the decidua there is cross-talk between DSC and EVT and immune cells. The effect of DSC secreted factors on EVT and immune cell function in the first trimester of pregnancy was investigated. Pre-eclampsia is associated with inadequate trophoblast invasion and spiral artery rem

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26

Powell, Richard Morgan. "Novel T cell function and specificity at the human maternal-fetal interface." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8334/.

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The mechanisms by which immune tolerance is maintained during human pregnancy are unclear but include a range of modifications to the local and systemic maternal immune system. There is considerable T cell infiltration of the maternal decidua during pregnancy, however, the functional properties of this T cell response remains poorly defined. We investigated the specificity and regulation of CD4+ and CDS+ T cells in human third trimester decidua and show that the ratio of highly differentiated effector to naive CD4+ and CDS+ T cells is increased markedly in comparison to peripheral blood. Decid

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27

Mitchell, Roderick T. "Germ cell development in the human and marmoset fetal testis and the origins of testicular germ cell tumours." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4818.

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Normal germ cell development in the human testis is crucial for subsequent fertility and reproductive health. Disruption of testis development in fetal life can result in deleterious health consequences such as testicular dysgenesis syndrome (TDS), which includes disorders, such as cryptorchidism, hypospadias, infertility and testicular germ cell tumours (TGCT). A rat model of TDS in which rats are exposed to phthalates in utero has been validated, but does result in the development of TGCT. In humans, TGCTs result from transformation of pre-neoplastic carcinoma in-situ (CIS) cells and these C

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28

Rounioja, S. (Samuli). "Experimental mouse model for fetal inflammatory response." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:951427783X.

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Abstract Intrauterine infections apparently cause about 85% of preterm deliveries at less than 28 weeks of gestation. Infection and inflammation play an important role in morbidity and mortality during perinatal period. The inflammatory mechanisms and pathophysiological consequences of intrauterine infection are poorly understood. According to current evidence from animal studies, the phenotypes of fetal inflammatory response are variable, ranging from spontaneous preterm birth to fetal death. The fetus is rather well protected against infectious agents by both structural and functional barrie

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29

Ene, Adriana. "Meiotic prophase progression and germ cell elimination in fetal and neonatal mouse ovaries." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92367.

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In most mammalian species, all oogonia cease mitotic proliferation and enter meiosis in fetal ovaries. Furthermore, more than half of the maximum number of germ cells is eliminated from ovaries by neonatal life, thus limiting the oocyte reserve for reproduction. The cause or mechanism of this female germ cell loss remains largely unknown. A major loss occurs in the oocytes which reach the pachytene stage of meiotic prophase, suggesting that oocytes with meiotic or recombination errors may be eliminated by a checkpoint mechanism. It remains to be determined whether oocytes are eliminated by apo

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30

Ofori-Acquah, Solomon Fiifi. "Molecular basis for CIS regulation of fetal haemoglobin expression in sickle cell disease." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324882.

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31

Zehri, Aqib Hyder. "Differential Effects of Pulsatile vs. Chronic Hyperglycemia on Fetal Pancreatic Beta Cell Population." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/145129.

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32

Middlebrook, Aaron J. "Nicotine and TNF alpha, modulators of T cell signaling-effects on T cell development in fetal thymus organ culture." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280628.

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T cell development is regulated by signals generated in the interactions between developing thymocytes and the thymic stroma. Using fetal thymus organ culture (FTOC) as a model of T cell development, we investigated the ability of two potent signal modulators to influence this process. These studies show that both nicotine and tumor necrosis factor-alpha have the ability to influence T cell receptor (TCR) signaling and the maturational capacity of treated cultures. FTOC treated with low concentrations of nicotine produced more immature T cells and fewer mature T cells. These expanded populatio

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33

Wang, Xin. "Endothelial cell activation and injury in umbilical placental vascular disease." Thesis, The University of Sydney, 2003. https://hdl.handle.net/2123/27854.

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34

Flansburg, Carroll Nicole. "Is Sickle Cell Trait as Benign as is Usually Assumed?" Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5017.

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Abstract Introduction Sickle cell trait carriers may experience sickling events, which can cause severe health problems. Some sickle cell haplotypes contain genetic modifiers that are associated with increased levels of fetal hemoglobin, which is resistant to sickling. The aim of this study is to determine if sickle cell trait individuals who do not carry these modifiers are more likely to experience sickling episodes than those who do carry the modifiers. Methods: Participants were eligible for inclusion in this study if they were male, 18 years of age or older, a sickle cell trait carrier, a

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35

Gill, Jagjit Singh. "Immunocytochemical characterization of components of the hemopoietic microenvironment in the mouse fetal liver." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59386.

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The fetal liver plays an important role in hemopoiesis during mammalian development. Morphological and immunocytochemical studies were carried out to identify and characterize cellular components that may be responsible for producing the liver hemopoietic environment. Cytospot preparations, from fetal livers of 11-18 days gestation, reacted with specific antibodies enabled us to characterize and quantitate the different cell populations.<br>Light microscope observations also showed areas of close cell associations involving two classes of central cells and peripheral erythroid cells. Such asso

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36

Stephen, Jillian. "Characterisation of effector and regulatory T-cell responses to blood group antigens." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24752.

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37

Dimovski, Aleksandar Jovo. "Factors affecting the fetal hemoglobin levels in patients with sickle cell anemia and thalassemia." [Maastricht : Maastricht : Rijksuniversiteit Limburg] ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=6583.

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38

Puszyk, William Matthew. "Epigenetics of cell-free plasma DNA for non-invasive prenatal diagnosis of fetal aneuploidies." Thesis, University of Warwick, 2008. http://wrap.warwick.ac.uk/1059/.

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Since the discovery of cell-free fetal DNA in the circulation of pregnant women fetal-specific DNA biomarkers for non-invasive prenatal diagnosis of fetal aneuploidy have been sought. A model system assessing the DNA methylation of placental DNA and adult peripheral leukocyte DNA has been developed previously to represent fetal and maternal plasma DNA. To use DNA methylation to detect specific DNA molecules it is desirable that cellfree plasma DNA maintains the methylation profile of its tissue source. Using the imprinted gene GNAS1, a test has been developed to assess, for the first time the

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39

Cannon, Matthew. "Large-scale Investigation of Fetal Hemoglobin Modulators and Inflammation Biomarkers in Sickle Cell Disease." The Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu16188574420699.

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40

Ramond, Cyrille. "Early T cell development in Mus Musculus : characterization of the fetal thymic settling progenitors." Paris 6, 2012. http://www.theses.fr/2012PA066452.

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Le thymus ne possède pas la capacité d’auto-renouvellement, il est dépendant de la migration de progéniteurs hématopoïétiques provenant du foie fœtal et de la moelle osseuse. La nature du Progéniteur Migrant au Thymus (PMT) reste inconnue et la caractérisation des Progéniteurs Thymiques Précoces (PTP) est sujette à controverse. Les PTP de jour Embryonnaire 12 (E12) sont restreints au potentiel T tandis que ceux du nouveau né gardent des potentiels de différenciation dans les voies B et myéloïde. Au cours de cette étude, nous avons analysé le compartiment des DN1 fœtal de jour E12 jusqu’au stad

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41

Barkley, Nicole Marie Garverick Henry Allen. "Characterization of apoptosis in the developing bovine fetal ovary association with germ cell loss /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6105.

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The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on October 9, 2009) Thesis advisor: Dr. H. Allen Garverick. Vita. Includes bibliographical references.

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42

Herrera-Gonzalez, Norma Estela. "Analysis of specfic immunoglobulin-secreting cells in the mid gestation mouse embryo : their potential role in fetal survival." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292371.

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43

Okumura, Leah M. "Germ cell nuclear factor is not required for the down-regulation of pluripotency markers in fetal ovarian germ cells." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77781.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>In mouse, germ cells retain expression of the pluripotency markers Oct4 and Nanog longer than any other cells in the body. While somatic cells repress these markers during gastrulation, female germ cells continue to express them until around the time of meiotic initiation. It is not yet clear why pluripotency markers are downregulated with this particular timing, nor is it understood what factors are involved in their repression. I

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Chen, Xiaochuan, Amy C. Kelly, Dustin T. Yates, Antoni R. Macko, Ronald M. Lynch, and Sean W. Limesand. "Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine." BIOSCIENTIFICA LTD, 2017. http://hdl.handle.net/10150/623222.

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Complications in pregnancy elevate fetal norepinephrine (NE) concentrations. Previous studies in NE-infused sheep fetuses revealed that sustained exposure to high NE resulted in lower expression of α2-adrenergic receptors in islets and increased insulin secretion responsiveness after acutely terminating the NE infusion. In this study, we determined if the compensatory increase in insulin secretion after chronic elevation of NE is independent of hyperglycemia in sheep fetuses and whether it is persistent in conjunction with islet desensitization to NE. After an initial assessment of glucose-sti

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45

Zabihi, Sheller. "Fetal Outcome in Experimental Diabetic Pregnancy." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8739.

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<p>Women with pregestational diabetes have a 2-5 fold increased risk of giving birth to malformed babies compared with non-diabetic women. Diabetes-induced oxidative stress in maternal and embryonic tissues has been implicated in the teratogenic process. The malformations are likely to be induced before the seventh week of pregnancy, when the yolk sac is partly responsible for the transfer of metabolites to the embryo, and the uterine blood flow to the implantation site determines the net amount of nutrients available to the conceptus. We aimed to evaluate the effect on embryogenesis caused by

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46

Gambero, Sheley. "Novos híbridos derivados de hidroxiureia e talidomida induzem a produção de hemoglobina fetal e apresentam atividade anti-inflamatória." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309314.

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Orientador: Fernando Ferreira Costa<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-19T03:49:55Z (GMT). No. of bitstreams: 1 Gambero_Sheley_D.pdf: 3649073 bytes, checksum: a76d9a7da22f0e08a3f4556b9b24330f (MD5) Previous issue date: 2011<br>Resumo: A anemia falciforme (AF) é um distúrbio genético da hemoglobina causado por uma mutação de ponto no gene da beta-globina com consequente produção de hemoglobina S (HbS). A polimerização de HbS causa a deformação, enrijecimento e diminuição da flexibilidade das hemácias, r

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47

El, Hoss Sara. "Novel insights into the role of fetal hemoglobin in spleen function, red cell survival and ineffective erythropoiesis in sickle cell disease." Thesis, Université de Paris (2019-....), 2019. https://theses.md.univ-paris-diderot.fr/ELHOSS_Sara_va2_20190924.pdf.

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La drépanocytose est une maladie génétique héréditaire récessive causée par la substitution d'un acide aminé dans la chaîne β-globine aboutissant à la production d'hémoglobine anormale (HbS). Dans des conditions hypoxiques, l’HbS polymérise entraînant une falciformation et une perte de déformabilité des globules rouges (GR). Au cours de la drépanocytose, le dysfonctionnement splénique entraîne des complications potentiellement mortelles, en particulier chez les jeunes enfants. Généralement, une asplénie fonctionnelle précède la survenue d’une asplénie anatomique avec cependant une grande varia

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48

Jobling, Matthew S. "Fetal germ cell development in the rat testis and the impact of di (n-Butyl) phthalate exposure." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4803.

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During gonad development and fetal life, the germ cells (GC) undergo a range of different developmental processes necessary for correct postnatal gametogenesis and the production of the next generation. If these fetal events are disrupted by genetic or environmental factors, there could be severe consequences that may not present until adulthood. This is of particular importance in relation to human testicular GC tumours (TGCT), the most common cancer of young men, as TGCT is thought to arise from fetal GCs that have failed to differentiate normally during development and thus persist into adu

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Nevalainen, Nina. "Effects of glial cell line-derived neurotrophic factor (GDNF) on mouse fetal ventral mesencephalic tissue." Thesis, Mälardalen University, Department of Biology and Chemical Engineering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-615.

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<p>The symptoms of Parkinson's disease occur due to degeneration of dopamine neurons in substantia nigra. It has been demonstrated that glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor when it comes to protect and enhance survival of dopamine neurons in animal models of Parkinson's disease. The aim of this study was to evaluate short- and long-term effects of GDNF on survival and nerve fiber outgrowth of dopamine cells and astrocytic migration in mouse fetal ventral mesencephalic (VM) tissue. Primary tissue cultures were made of mouse fetal VM tissue and evalu

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Yamada(Takahara), Sachiko. "Programmed cell death is not a necessary prerequisite for fusion of the fetal mouse palate." Kyoto University, 2004. http://hdl.handle.net/2433/147567.

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