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Dissertations / Theses on the topic 'Fetal respiratory distress syndrome'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Rocker, Graeme Martin. "Studies on adult respiratory distress syndrome." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235866.

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2

Wetterberg, Torbjörn. "Treatment of critical respiratory failure in adult respiratory distress syndrome." Lund : Dept. of Anesthesiology and Intensive Care, Lund University, University Hospital, 1992. http://books.google.com/books?id=WBVsAAAAMAAJ.

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3

Dushianthan, Ahilanandan. "Phospholipid kinetics in acute respiratory distress syndrome." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/374568/.

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4

Clark, Simon John. "Right ventricular function in respiratory distress syndrome." Thesis, University of Liverpool, 2001. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250478.

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5

Davet, Dominique. "A nonlinear model of heart rate variability applied to cardiorespiratory interactions in adults and infants." Thesis, Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/17614.

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6

Henderson, William Roy. "Expiratory time constant heterogeneity in experimental acute respiratory distress syndrome." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58370.

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Purpose This thesis evaluated regional heterogeneity of pulmonary mechanical values within models of lung injury. To this end four separate studies were completed. I evaluated regional expiratory time constant (τE) heterogeneity and tissue strain (ε) in a lung model using functional respiratory imaging (FRI) (Study 1, Chapter 2), and developed an in vivo porcine model of lung injury (Study 2, Chapter 3). This model was used to assess changes in τE due to manipulations of respiratory gas density (Study 3, Chapter 4) and mechanical ventilation parameters (Study 4, Chapter 5). Methods Study

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7

Ainsworth, Sean B. "The impact of exogenous surfactant in neonatal respiratory distress syndrome." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/23306.

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Several exogenous surfactants are currently available and whilst controlled trials have demonstrated surfactant therapy is better than placebo, there are several unanswered questions that this thesis addresses through a review of existing evidence; 1. Which surfactant preparation is clinically more efficacious? 2. The choice between “rescue” (treatment after the development of RDS) or “prophylaxis” (prevention of RDS). 3. How many doses of surfactant are needed and what is the evidence for the size of the doses currently used? Four exogenous surfactant preparations - two synthetic and two anim

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8

San, Angelo Donna. "THE EFFECT OF BODY POSITION ON RESPIRATORY FUNCTION IN THE INFANT WITH RESPIRATORY DISTRESS SYNDROME." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/275429.

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9

Muzaffar, Saima. "Reactive oxygen species and the pathophysiology of adult respiratory distress syndrome." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271916.

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10

Greene, Michelle Kathleen. "Therapeutic evaluation of an immunomodulatory nanoparticle in acute respiratory distress syndrome." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680123.

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Acute Respiratory Distress Syndrome (ARDS) is characterised by dysregulated inflammation within the lungs, which can severely compromise pulmonary architecture and function. Despite intensive efforts to develop therapies for ARDS, there are no curative pharmacological interventions at present. Instead, management of ARDS is primarily supportive and the syndrome is associated with substantial mortality, morbidity and healthcare expenditure. In pursuit of an effective ARDS therapy, this thesis explored the potential application of a novel sialic acid-functionalised nanoparticle (SNP). This nanop

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11

Lidegran, Marika. "Advanced radiological imaging in patients treated with extracorporeal membrane oxygenation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-933-5/.

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12

Thommasen, Harvey Victor. "The role of the polymorphonuclear leukocyte in the pathogenesis of the adult respiratory distress syndrome." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25058.

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This study was designed to follow up a chance observation in patients with an admission white blood cell (WBC) count showing an absolute lymphocytosis and relative neutropenia that changed to a lymphopenia and neutrophilia within 24 hours. As 15 of the 20 patients were admitted following trauma, we examined this association further by reviewing charts of 69 patients who had sustained stab wounds to the chest and abdomen. A prospective study involving 40 patients in the Intensive Care Unit was also undertaken because of the related hypothesis that the Adult Respiratory Distress Syndrome (ARD

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13

Wang, Jiu-Yao. "Expression and functional characterization of carbohydrate recognition domains of bovine conglutinin and human lung surfactant protein D." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318456.

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14

Mockridge, J. N. A. "A computer-controlled synchronous ventilator for neonates." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282930.

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15

Davreux, Christopher J. "Antioxidant therapy for the management and prevention of adult respiratory distress syndrome." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0003/MQ34060.pdf.

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16

Lindwall, Robert B. I. "Respiratory distress syndrome : aspects of inhaled nitric oxide surfactant and nasal CPAP /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-297-7/.

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17

Halahakoon, W. L. D. C. N. "A study of cerebral function following surfactant treatment for respiratory distress syndrome." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301741.

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18

Sefic, Pasic Irmina. "The role of lung ultrasonography in the evaluation of neonatal respiratory distress syndrome." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669429.

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Objetivo de nuestro estudio fue evaluar la capacidad diagnóstica de la ecografía pulmonar en el diagnóstico del Síndrome del Distrés Respiratorio (SDR), así como en el seguimiento de la respuesta al tratamiento. La ecografía pulmonar se comparó con los rayos X como método estándar de diagnóstico y seguimiento de pacientes con SDR. La escala radiográfica de cuatro grados se comparó con perfiles de ultrasonido de tres grados. El segundo objetivo era hacer un cálculo de las dosis recibidas debido a la radiografía de tórax en niños incluidos en el estudio. También se compararon los hallazgos

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19

Raine, Joseph. "The use of continuous negative extrathoracic pressure in the neonatal respiratory distress syndrome." Thesis, University of Manchester, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508168.

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Our aim was to re-evaluate the role of CNEP in RDS using a modified CNEP chamber. The new CNEP system comprised a thin (0.25 mm) rubber neck seal, facilities for routine and emergency patient access and an air controlled incubator heater. The protocol of the randomised controlled trial of CNEP in RDS is presented. There were 122 matched pairs in the trial. The trial showed that CNEP leads to a fall in the mean duration of oxygen therapy (-15.3, 95% CI -30.4 to -0.2 days), and to a decrease in the incidence of BPD (-12, 95% CI -23 to -1%). Patients in the CNEP limb also had a substantially decr

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20

Jia, Xiaoming M. Eng Massachusetts Institute of Technology. "The effects of mechanical ventilation on the development of Acute Respiratory Distress Syndrome." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/41629.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2007.<br>Includes bibliographical references (p. 74-76).<br>Acute Respiratory Distress Syndrome (ARDS) is a severe lung illness characterized by inflammation and fluid accumulation in the respiratory system. Historically, ARDS and other forms of respiratory failure have been treated using mechanical ventilation to help maintain gas exchange in the lungs. However, clinical investigators are beginning to discover the adverse effects of mechanical ventilation if it is not applied properl

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21

ISAK, ILENA. "STABLE ISOTOPE TRACERS TO ESTIMATE SURFACTANT METABOLISM IN NEWBORNS WITH RESPIRATORY DISTRESS SYNDROME." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427467.

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Aims of the thesis are to describe new applications of stable isotope tracers, applied to study pulmonary surfactant kinetics in human newborns. My PhD project was initially focused on the most suitable metabolic substrate to measure surfactant DSPC synthesis and more specifically on the difference between de-novo synthesis an remodeling synthesis using free fatty acids derived from the circulating blood. In the second part a newly synthesized stable isotope tracer, 2H3-U13C PA-DPPC, was used to investigate the different kinetics of the sn-1 and sn-2 palmitate moieties in infants with differ

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22

Jordan, Simon James. "The pathogenesis of lung injury following cardiothoracic surgery." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249727.

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23

Quinlan, Gregory John. "Oxidative damage to extracellular proteins and lipids during acute lung injury." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281713.

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24

Aggarwal, Anjna. "Mediators and mechanisms of persistent pulmonary neutrophilia in acute lung injury." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289880.

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25

Peters, Mark John. "The role of platelets in acute inflammation." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271069.

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26

Rocksʹen, David. "Acute lung injury : study of pathogenesis and therapeutic interventions /." Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161.

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27

Harkin, Denis William. "Modulation of the systemic inflammatory response syndrome in lower limb ischaemia-reperfusion injury." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326388.

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28

Zhai, Ruoyang. "Effects of sevoflurane in the treatment of Acute Respiratory Distress Syndrome : a translational approach." Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2023. http://www.theses.fr/2023UCFA0077.

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Le syndrome de détresse respiratoire aiguë est une cause majeure d'insuffisance respiratoire avec un taux de mortalité élevé. Elle se caractérise par des lésions alvéolaires diffuses, un œdème alvéolaire et une défaillance respiratoire hypoxémique qui entraînent de lourds coûts de santé. Actuellement, les traitements disponibles pour le SDRA restent principalement de soutien, et aucune approche pharmacologique n'est traduite avec succès en application clinique. Il existe deux processus majeurs au cours du développement physiopathologique du SDRA qui conduisent à la formation d'un œdème pulmona

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29

Todd, Susan Katharine. "Shock assisted ventilation." Thesis, University of Surrey, 1999. http://epubs.surrey.ac.uk/843314/.

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Respiratory distress syndrome is the major cause of mortality in premature babies. Increasing numbers of neonates are now surviving the disease due to advances in techniques used in neonatal intensive care units. Mechanical ventilation is an essential part of the treatment for respiratory distress syndrome and is an area in which improvements and modifications are constantly being made. In the early 1980's a new infant ventilator was introduced involving ventilation by a distal jet. As yet, the mechanisms by which the distal jet ventilator enhances gas exchange are unknown. Original experiment

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30

Baker, Cathy Sue. "Rationale for surfactant replacement therapy in patients with acute lung injury." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243281.

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31

Pitt, Tracy Shawn. "Effects of temperature and anticoagulant on the in vitro quantitation of Leukocyre Expressed Mac-1 and Post-traumatic assay to predict the development of ARDS." Youngstown State University / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ysu996864777.

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32

Camprubí, Rimblas Marta. "Nebulized anti-coagulants as a therapy for acute lung injury and acute respiratory distress syndrome." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/663961.

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La síndrome de distrés respiratori agut (ARDS) és una insuficiència respiratòria aguda amb una incidència global a Europa de 17,9 per cada 100.000 persones-any. Tot i els avenços en el tractament de suport dels pacients amb ARDS, la mortalitat continua sent alta (40%) i els pacients que sobreviuen presenten seqüeles persistents. Actualment no existeix un tractament efectiu. La fisiopatologia de l’ARDS es caracteritza per l’activació de la coagulació i la inflamació a nivell pulmonar, juntament amb el trencament de la barrera alveolar-capil·lar. Això comporta la formació d’edema proteic, la in

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33

Morrison, Thomas. "Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome." Thesis, Queen's University Belfast, 2017. https://pure.qub.ac.uk/portal/en/theses/human-mesenchymal-stromal-cell-regulation-of-pulmonary-macrophage-populations-in-the-acute-respiratory-distress-syndrome(da547b07-7974-436a-8943-7e2ddf3933cc).html.

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The Acute Respiratory Distress Syndrome (ARDS) is a devastating clinical disorder characterised by excessive inflammation in the alveolar compartment resulting in oedema of the airspaces due to loss of integrity in the alveolar epithelial-endothelial barrier. ARDS is associated with high mortality rates and there are currently no effective pharmacological therapies available. Human Mesenchymal Stromal Cells (hMSCs) are a promising candidate therapy which are currently being investigated in clinical trials for ARDS. However their mechanisms of effects in lung injury are not fully elucidated. A

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34

Chen, Yan Mi. "Regulation of iron mediated signalling processes during endotoxaemia : implications for the acute respiratory distress syndrome." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395766.

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35

Singh, Nanak. "Incidence and pathogenesis of acute lung injury and the acute respiratory distress syndrome in humans." Thesis, University of East Anglia, 2013. https://ueaeprints.uea.ac.uk/48050/.

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Acute lung injury (ALI) and it’s more severe form, acute respiratory distress syndrome (ARDS), are conditions characterised by neutrophilic pulmonary inflammation, refractory hypoxaemia and diffuse alveolar damage. This work reports on the first UK based prospective study of the incidence and longer term mortality of ALI/ARDS in a general intensive care unit. Results reveal significant under recognition of this condition, which occurred in 12.5% of the ICU population (n=344). Hospital and 2 year mortality rates were 50-55% and 58-61% respectively. Neutrophils are central in the pathogenesis of

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36

Martin, Collin Armand. "Pathology of complicated Babesia rossi-associated acute lung injury and respiratory distress syndrome in dogs." Diss., University of Pretoria, 2020. http://hdl.handle.net/2263/77412.

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A proportion of Babesia rossi infections in dogs are classified as complicated. One of the most lethal complications is the acute lung injury (ALI) and acute respiratory destress syndrome (ARDS). Patients affected by this complication usually succumb within 24 hours and there are similarities between this disease and malaria associated ALI and ARDS in humans, both rapidly fatal conditions. Both diseases are caused by haemoprotozoal parasites transmitted by insect vectors, namely ticks for babesiosis and mosquitoes for malaria. The pulmonary pathology of complicated babesiosis is poorly describ

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37

Güldner, Andreas, Robert Huhle, Alessandro Beda, et al. "Periodic Fluctuation of Tidal Volumes Further Improves Variable Ventilation in Experimental Acute Respiratory Distress Syndrome." Frontiers Research Foundation, 2018. https://tud.qucosa.de/id/qucosa%3A32492.

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In experimental acute respiratory distress syndrome (ARDS), random variation of tidal volumes (VT ) during volume controlled ventilation improves gas exchange and respiratory system mechanics (so-called stochastic resonance hypothesis). It is unknown whether those positive effects may be further enhanced by periodic VT fluctuation at distinct frequencies, also known as deterministic frequency resonance.We hypothesized that the positive effects of variable ventilation on lung functionmay be further amplified by periodic VT fluctuation at specific frequencies. In anesthetized and mechanically ve

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38

St, Clair Caryn M. "Neonatal Respiratory Distress Syndrome as a Function of Gestational Age and the Lecithin/Sphingomyelin Ratio." [New Haven, Conn. : s.n.], 2007. http://ymtdl.med.yale.edu/theses/available/etd-08272007-123115/.

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39

Bohlin, Kajsa. "Surfactant metabolism in the newborn : the impact of ventilation strategy and lung disease /." Stockholm : Karolinska institutet, 2005. http://diss.kib.ki.se/2005/91-7140-229-2/.

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40

Yang, Li. "Studies on the effects of pharmacological agents on endotoxin induced pulmonary injury." Thesis, University of Hawaii at Manoa, 2003. http://proquest.umi.com/pqdweb?index=2&did=764805101&SrchMode=2&sid=10&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1233179468&clientId=23440.

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41

Koshy, Shyny. "Low tidal volume ventilation as a strategy for inducing lung fluid absorption in the preterm guinea pig." [Kent, Ohio] : Kent State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1247949798.

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42

Crag, Thelma R. "Investigation into the mechanisms and treatment of acute living injury and the acute respiratory distress syndrome." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534709.

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43

Dancer, Rachel Catherine Anne. "Investigation into a potential role for vitamin D in the pathogenesis of acute respiratory distress syndrome." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7859/.

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Patients undergoing oesophagectomy are at risk of developing Acute Respiratory Distress Syndrome (ARDS), an immune mediated form of severe respiratory failure. The immunomodulatory properties of Vitamin D are increasingly recognised. We hypothesised that preoperative Vitamin D supplementation would reduce levels of perioperative alveolar oedema in patients undergoing oesophagectomy. Vitamin D deficiency is common in patients with and at risk of ARDS. High dose supplementation with cholecalciferol is a safe and effective method of increasing Vitamin D levels. Supplementation reduces perioperati

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44

Espinosa, Frank F. (Frank Francis). "Exogenous surfactant transport through the pulmonary airways : improving surfactant replacement therapy for neonatal respiratory distress syndrome." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/10974.

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45

Hamid, Umar Imran. "Use of clinically relevant human models to test novel therapies for the acute respiratory distress syndrome." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695362.

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In the current era, there are no effective therapies for the treatment of acute respiratory distress syndrome (ARDS) despite numerous clinical trials. Current strategies are aimed at improving pulmonary perfusion, recruitment of atelectatic alveoli and reducing iatrogenic injuries to the lung. The human models of ARDS give important information when testing potential drug therapies and serve as a bridge between experimental studies and phase 11/111 clinical trials. I was able to establish the ex vivo lung perfusion model and studied the effects of aspirin in reducing pulmonary inflammation pro

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46

Retamal, Montes Jaime. "Aspects on ventilation induced stress and strain on regional and global inflammation in experimental acute respiratory distress syndrome." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-296952.

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Mechanical ventilation (MV) is a life-saving therapy in acute respiratory distress syndrome (ARDS), a condition that affects 3000 patients/year in Sweden with a mortality rate of about 40%. However, MV may induce or worsen lung injury causing “ventilator-induced lung injury (VILI)”. From a mechanical perspective strain (deformation, or relative change in lung volume) and stress (tension) have been postulated as main determinants of VILI. High respiratory rate is potentially another factor that may exacerbate VILI by amplifying the total energy transmitted to the lungs during MV. In this thesis

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47

Haataja, R. (Ritva). "The role of surfactant protein A and B genes in heritable susceptibility to neonatal respiratory distress syndrome." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514265254.

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Abstract Respiratory distress syndrome (RDS) is a disease characterized by neonatal respiratory failure. It is principally caused by a deficiency of pulmonary surfactant, which is a lipoprotein mixture essential for reducing surface tension at the air-liquid interface of the alveolus. Prematurity is the major risk factor predisposing to RDS. Several pieces of evidence suggest the role of genetic factors in the susceptibility to this multifactorial disease. The present study was performed to determine whether polymorphisms of the surfactant protein SP-A1, SP-A2 and SP-B genes associate

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48

Tubau, Llopart Isabel. "Biomarkers of oxidative stress in acute respiratory distress syndrome in exhaled breath measured online by mass spectrometry." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/96305.

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Introducció: En el context de la síndrome del destret respiratori agut (SDRA), neutròfils activats emigren dels capil·lars pulmonars cap a l’alvèol i a l'espai intersticial, on alliberen radicals lliures d'oxigen anomenats espècies reactives de l’oxigen (ROS) que juguen un paper molt important en la patogènesis del SDRA. La secreció de ROS i d'altres mediadors proinflamatoris culminen en la lesió de la membrana alveolo-capil·lar, causant increment de la permeabilitat i edema pulmonar. Quan ROS interaccionen amb els lípids de les membranes de les cèl·lules pulmonars, té lloc un procés anomenat

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49

Marttila, R. (Riitta). "Epidemiological and genetic study of respiratory distress syndrome in preterm infants:specific aspects of twin and multiple births." Doctoral thesis, Oulun yliopisto, 2003. http://urn.fi/urn:isbn:9514272145.

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Abstract Respiratory distress syndrome, RDS, is a multifactorial lung disease of premature infants. The main cause of RDS is a deficiency of pulmonary surfactant, a lipoprotein mixture required to reduce surface tension at the air-liquid interface and to prevent generalized atelectasis of the alveolar ducts and alveoli. Prematurity is the most important factor predisposing to RDS. During the past decade the number of multiple pregnancies has increased significantly as a result of diversified infertility treatments and advanced maternal age. Due to the considerably higher rate of preterm births

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50

Yuan, Hai-Tao. "Molecular basis of respiratory distress syndrome and its acquired tolerance to oxygen toxicity in premature guinea-pig." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287202.

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