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Journal articles on the topic 'Fetal teratogenicity'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Pop, Lucian, Nicolae Bacalbasa, Irina Balescu, Vlad Dima, and Roxana Elena Bohiltea. "Retinoids and teratogenicity." Romanian Journal of Pediatrics 70, no. 4 (2021): 219–20. http://dx.doi.org/10.37897/rjp.2021.4.3.

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For more than 30 years, retinoids have been used for acne treatment also their teratogenic effects are widely known. For any woman at a fertility age and under retinoid treatment, a contraception program should be in place. Pregnancy should be postponed until the completion of treatment and one month afterwards. Multiple fetal abnormalities are directly linked to isotretinoin.

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Cohen-Kerem, Raanan, and Gideon Koren. "Antioxidants and fetal protection against ethanol teratogenicity." Neurotoxicology and Teratology 25, no. 1 (2003): 1–9. http://dx.doi.org/10.1016/s0892-0362(02)00324-0.

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Chawla, Dr Sumit Pal Singh, Dr Sarabjot Kaur, Dr Mohit Garg, Dr Gurrajan Nikhanj, and Dr Gurveer Kaur. "Pregnancy with Epilepsy." Scholars Journal of Applied Medical Sciences 10, no. 7 (2022): 1073–77. http://dx.doi.org/10.36347/sjams.2022.v10i07.007.

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Epilepsy (Seizure disorder) is one of the most common neurological conditions encountered in pregnancy. The management of epilepsy during pregnancy is quite challenging. The goal of treatment is optimal seizure control with minimal or no in-utero fetal exposure to AEDs in order to minimize the risk of teratogenicity.

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Jain, Soniya A., Madhavi Awale, Sulabha Pathak, Geeta Vanage, Vandana B. Patravale, and Shobhona Sharma. "Teratogenicity of Artemether–Clindamycin Nanostructured Lipid Carriers in Rats." International Journal of Toxicology 35, no. 4 (2016): 420–28. http://dx.doi.org/10.1177/1091581816652605.

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Currently, artemisinin-based combination therapy is considered the best option in the treatment of malaria. However, toxicity of artemisinins limits their use in pregnancy. In the absence of sufficient toxicity data, the World Health Organization recommends that artemisinins are not to be used in the first trimester of pregnancy and can be used only in second and third trimesters, when other treatments are not available. We have recently observed that drugs loaded in nanolipid carriers are selectively taken up in Plasmodium-infected erythrocytes with a concomitant reduction in the dose require

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Nasreen, Noor Suhail Ahmed Almani Shafaq Nazia Muhammad Iqbal Shah* Aatir H. Rajput Muhammad Muneeb Syed Jehangir and Shahrukh Shaikh. "CROSS-SECTIONAL ANALYSIS OF DANGERS INHERENT WITH PRE AND POST PARTUM USE OF ANTICOAGULATION THERAPY." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1422–25. https://doi.org/10.5281/zenodo.817584.

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Background:The rate of thrombotic mal-events is three-fold to five-fold greater during pre-partum and post-partum phases than at any other time in a women’s life and thus many women receive anticoagulant therapy during pregnancy and puerperium, despite evidence suggesting that this therapy may pose grave danger to the well-being of the fetus and the mother. Objective: This research hopes to highlight the dangers inherent (to the mother and fetus) with the pre-partum and post-partum use of anti-coagulation therapy. Methodology This retrospective analysis is built upon the primary data, availabl

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Hari, Dr Anupama, Dr Bushra Shereen, and Dr J. Sreeja Shraddha. "Anti-Neoplastic Drug Exposure in Pregnancy and Fetal Haemorrhage: A Rare Teratogenicity." Scholars International Journal of Obstetrics and Gynecology 5, no. 3 (2022): 130–32. http://dx.doi.org/10.36348/sijog.2022.v05i03.011.

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Anti-neoplastic drugs are known to have teratogenic effects on the fetus. In this case report we are presenting a case of a patient who got operated for breast carcinoma, conceived while on chemotherapy and underwent termination of pregnancy in the second trimester. Fetal haemorrhage and ecchymosis lead to further evaluation of the case, which revealed fetal thrombocytopenia, a rare teratogenic effect of the anti-neoplastic drugs.

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Gupta, Rohini, Brij Mohan Gupta, and Apeksha Gupta. "Impact of educational intervention on the awareness of undergraduate medical students towards teratogenicity: an observational study." International Journal of Basic & Clinical Pharmacology 7, no. 9 (2018): 1842. http://dx.doi.org/10.18203/2319-2003.ijbcp20183500.

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Background: The term teratogenicity is defined as any morphological, behavioral or biochemical effect induced during embryonic life or fetal life detected at birth or later. the factors that lead to teratogenicity include both non-genetic and genetic factors. The objective of the present study was to assess the impact of educational interventions on the awareness of undergraduate medical students towards teratogenicityMethods: The present study was a questionnaire-based comparative observational study carried out at Department of Pharmacology and Therapeutics, Government Medical College, Jammu

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8

Koren, Gideon, and Sheri Nickel. "Sources of bias in signals of pharmaceutical safety in pregnancy." Clinical & Investigative Medicine 33, no. 6 (2010): 349. http://dx.doi.org/10.25011/cim.v33i6.14585.

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Every year scores of new pharmaceuticals enter the market, almost never with human fetal safety data. Such data typically accumulate during the first years of clinical use, in the form of case reports, case series, prospective and retrospective cohorts and case control studies. All of these methods suffer from serious sources of bias, often leading to alarming signals of teratogenicity that are later found to be false. This review highlights major sources of bias, including the bias against the null hypothesis in its different forms, ascertainment and recall bias, in fetal exposure to pharmace

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9

Olegård, Ragnar. "Alcohol and Narcotics:Epidemiology and Pregnancy Risks." International Journal of Technology Assessment in Health Care 8, S1 (1992): 101–5. http://dx.doi.org/10.1017/s0266462300012988.

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AbstractAmong alcohol and narcotics, alcohol is most comprehensively documented as a teratogen. However, for all other narcotics, data are continuously accumulating, convincingly displaying the teratogenic effects. The proportions between “somatic” teratogenicity and “behavioral” teratogenicity vary between the different agents. Preventive work in prenatal clinics and among social workers, as well as objective mass media attention to the problem, seems to have lowered the incidence of severe fetal alcohol syndrome where the above-mentioned activities have been practiced. The female alcohol con

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Flentke, George R., and Susan M. Smith. "The avian embryo as a model for fetal alcohol spectrum disorder." Biochemistry and Cell Biology 96, no. 2 (2018): 98–106. http://dx.doi.org/10.1139/bcb-2017-0205.

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Prenatal alcohol exposure (PAE) remains a leading preventable cause of structural birth defects and permanent neurodevelopmental disability. The chicken (Gallus gallus domesticus) is a powerful embryological research model, and was possibly the first in which the teratogenicity of alcohol was demonstrated. Pharmacologically relevant exposure to alcohol in the range of 20–70 mmol/L (20–80 mg/egg) disrupt the growth of chicken embryos, morphogenesis, and behavior, and the resulting phenotypes strongly parallel those of mammalian models. The avian embryo’s direct accessibility has enabled novel i

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11

Goyal, Manisha, Ashok Gupta, Manish Sharma, Priyanshu Mathur, and Naresh Bansal. "Fetal Valproate Syndrome with Limb Defects: An Indian Case Report." Case Reports in Pediatrics 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/3495910.

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Epilepsy is a common disorder and exposure to antiepileptic drugs during pregnancy increases the risk of teratogenicity. Older AEDs such as valproate and phenobarbital are associated with a higher risk of major malformations in the fetus than newer AEDs like lamotrigine and levetiracetam. Exposure to valproic acid during first trimester can result in fetal valproate syndrome (FVS), comprising typical facial features, developmental delay, and a variety of malformations such as neural tube defects, cardiac and genitourinary malformations, and limb defects. We are presenting an Indian case of FVS

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12

Zachariah, Krista A., Su Yuan, Maria T. DeSancho, Inna V. Landres, and Harsimran S. Singh. "Role of Antiplatelets and Anticoagulation Therapies in Pregnancy." Journal of Clinical Medicine 13, no. 24 (2024): 7757. https://doi.org/10.3390/jcm13247757.

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Thrombosis is an important cause of morbidity and mortality worldwide. Pregnancy is a hypercoagulable state, and thrombotic complications in pregnancy are a major cause of maternal and fetal morbidity and mortality. Current guidelines support the selective use of aspirin, heparin, and warfarin in pregnant women. The decision to treat with antiplatelets and anticoagulants during pregnancy can be challenging, as these agents have numerous indications and contraindications, potential teratogenicity, and dosing considerations. Their use requires thoughtful discussion between patient and provider t

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13

Chhandamayee, Mohanty, Shah Nilam, Dhungel Shaligram, and K. Das B. "Effect of Lamotrigine on Fetal Rat Brain." PJSR 4, no. 2 (2011): 5–7. https://doi.org/10.5281/zenodo.8268003.

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Studies on the effect of lamotrigine on fetal brain are limited. The present experimental study was conducted to explore any macroscopic or microscopic changes in fetal brain induced by lamotrigine. Pregnant albino wistar rats received 1.5 mg oral lamotrigine on day 9 to 11 of pregnancy and the pups were harvested on day 20. The mean body weight and length were lower and brain weight and volume were higher of the pups exposed to lamotrigine. However, the differences were not statistically significant. Some of the experimental pups had exencephaly and haemorrhages over the body. Histology of th

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AbdRabou, Mervat A., Barakat M. Alrashdi, Hadeel K. Alruwaili, et al. "Exploration of Maternal and Fetal Toxicity Risks for Metronidazole-Related Teratogenicity and Hepatotoxicity through an Assessment in Albino Rats." Toxics 11, no. 4 (2023): 303. http://dx.doi.org/10.3390/toxics11040303.

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Metronidazole is the primary antimicrobial drug for treating acute and chronic vaginal pathogens during pregnancy; however, there has been insufficient research on placental disorders, early pregnancy loss, and preterm birth. Here, the potential activity of metronidazole on pregnancy outcomes was investigated. 130 mg/kg body weight of metronidazole was orally given individually to pregnant rats on gestation days 0–7, 7–14, and 0–20. Pregnancy outcome evaluations were carried out on gestation day 20. It was demonstrated that metronidazole could induce maternal and fetal hepatotoxicity. There is

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15

ALTINTAŞ AYKAN, Duygun. "CURRENT RESEARCH IN THE FIELD OF ANTIHYPERTENSIVE DRUGS AND TERATOGENICITY." Arşiv Kaynak Tarama Dergisi 32, no. 2 (2023): 61–67. http://dx.doi.org/10.17827/aktd.1237593.

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Gebelikte hipertansif bozukluklar, dünya çapında gebeliklerin en yaygın tıbbi komplikasyonlarındandır. Gebelik sırasında hipertansiyonu tedavi etme kararı, hem anne hem de fetüs için riskleri ve yararları göz önünde bulundurularak alınmalıdır. Hipertansiyon tedavisinin amacı maternal riski azaltmak olsa da, seçilen ajanlar fetüs için güvenli olmalıdır. Uzun vadeli prognoz, tahmini maternal risk ve beklenen fetal sonuçlar multidisipliner bir yönetim planı oluşturularak hasta ile paylaşılmalıdır. Bu çalışmada, gebelik sırasında hipertansiyon tedavisine ilişkin kılavuzlar, antihipertansif ilaçlar

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Lee, Jia-Yee, and D. Scott Bowden. "Rubella Virus Replication and Links to Teratogenicity." Clinical Microbiology Reviews 13, no. 4 (2000): 571–87. http://dx.doi.org/10.1128/cmr.13.4.571.

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SUMMARY Rubella virus (RV) is the causative agent of the disease known more popularly as German measles. Rubella is predominantly a childhood disease and is endemic throughout the world. Natural infections of rubella occur only in humans and are generally mild. Complications of rubella infection, most commonly polyarthralgia in adult women, do exist; occasionally more serious sequelae occur. However, the primary public health concern of RV infection is its teratogenicity. RV infection of women during the first trimester of pregnancy can induce a spectrum of congenital defects in the newborn, k

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17

Kárpáti, Andrea, I. Takács, L. Várnagy, P. Budai, and E. Molnár. "Interaction OF Dithane M-45 (MANCOZEB) and Lead Acetate during a teratogenicity test In rats." Acta Veterinaria Hungarica 48, no. 1 (2000): 113–24. http://dx.doi.org/10.1556/avet.48.2000.1.13.

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The teratogenic effects of lead acetate (Trial 1) and the possible teratogenic effect of this compound administered in combination with a fungicide containing 80% mancozeb (Trial 2) were studied in rats. The test substances were administered by gavage on Days 6-15 of gestation. In Trial 1, five groups were treated with lead acetate administered at doses of 0.1, 0.5, 1.0, 10.0 and 1000.0 mg/kg body weight (bwkg), respectively. In Trial 2, lead acetate was applied at doses of 0.1, 10.0 and 1000.0 mg/bwkg, respectively. In the latter case the dose of the pesticide was 750 mg/bwkg in all treated g

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18

Hau, J., A. Basse, and C. Wolstrup. "A murine model for the assessment of placental and fetal development in teratogenicity studies." Laboratory Animals 21, no. 1 (1987): 26–30. http://dx.doi.org/10.1258/002367787780740699.

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During normal pregnancy in the mouse, maternal serum levels of the analogues to human schwangerschaftsprotein-1 and α-fetoprotein correlate significantly with the growth of the placenta and fetus respectively. This relationship has been utilized in the analysis of the effect of sodium selenite on placental and fetal growth in mice. Moderate doses of sodium selenite did not affect the growth of the placenta and fetus significantly, whereas high doses of selenite resulted in a large percentage of abortions. The protein markers were found to be useful in the prediction of placental and fetal grow

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19

Da Cunha Ferreira, R. M. C., I. Monreal Marquiegui, and I. Villa Elizaga. "Teratogenicity of zinc deficiency in the rat: Study of the fetal skeleton." Teratology 39, no. 2 (1989): 181–94. http://dx.doi.org/10.1002/tera.1420390210.

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Ciaravino, Vic, Dina Coronado, Cheryl Lanphear, Alan Hoberman, and Sanjay Chanda. "Tavaborole, a Novel Boron-Containing Small Molecule Pharmaceutical Agent for Topical Treatment of Onychomycosis." International Journal of Toxicology 35, no. 5 (2016): 530–42. http://dx.doi.org/10.1177/1091581816639113.

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Tavaborole is a topical antifungal agent approved by the US Food and Drug Administration for the treatment of toenail onychomycosis. As part of the nonclinical development program, reproductive and developmental toxicity studies were conducted (rat oral fertility and early embryonic development, rat (oral) and rabbit (dermal) embryo–fetal development). There were no effects on fertility or reproductive performance at doses up to 300 mg/kg/d (107 times the maximum recommended human dose [MRHD] based on mean area under the plasma concentration–time curve comparisons). In the rat embryo–fetal dev

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Hoyme, H. Eugene, Kenneth Lyons Jones, Suzanne D. Dixon, et al. "Prenatal Cocaine Exposure and Fetal Vascular Disruption." Pediatrics 85, no. 5 (1990): 743–47. http://dx.doi.org/10.1542/peds.85.5.743.

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The question of the potential teratogenicity of cocaine has been raised by the increasing frequency of its abuse in the United States. In previous studies, an increased incidence has been documented of spontaneous abortion, placental abruption, prematurity, intrauterine growth retardation, and neurologic deficits in the infants of women who abused cocaine. More recently, it has been suggested in studies that fetal vascular disruption accompanying maternal cocaine abuse may lead to cavitary central nervous system lesions and genitourinary anomalies. In this article, 10 children born of women wh

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Sambo, Danielle, and David Goldman. "Genetic Influences on Fetal Alcohol Spectrum Disorder." Genes 14, no. 1 (2023): 195. http://dx.doi.org/10.3390/genes14010195.

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Fetal alcohol spectrum disorder (FASD) encompasses the range of deleterious outcomes of prenatal alcohol exposure (PAE) in the affected offspring, including developmental delay, intellectual disability, attention deficits, and conduct disorders. Several factors contribute to the risk for and severity of FASD, including the timing, dose, and duration of PAE and maternal factors such as age and nutrition. Although poorly understood, genetic factors also contribute to the expression of FASD, with studies in both humans and animal models revealing genetic influences on susceptibility. In this arti

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Chaudhari, Prathamesh V., Reshma Jadhav, Ashish Jain, Priya D. Jagtap, Bhavesh D. Mahajan, and Prapti Gawand. "A comprehensive review on drug-induced diseases and teratogenicity." Prospects in Pharmaceutical Sciences 23, no. 1 (2025): 66–73. https://doi.org/10.56782/pps.307.

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The phrase "drug induced disease" refers to an unintentional pharmacological side effect that causes mortality and morbidity and symptoms severe enough to necessitate hospitalization or medical attention. Anticoagulants, anticonvulsant, anti-seizure agents, antiepileptics, and antihistamines are among the drugs whose fetal developmental toxicity has been shown by epidemiological studies. These drugs can cause miscarriage, birth defects, and other adverse pregnancy outcomes. The primary method for diagnosing drug-related disorders in patients is the patient's or their family's history of drug u

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Wong, Mayme, and Peter G. Wells. "Effects of N-acetylcysteine on fetal development and on phenytoin teratogenicity in mice." Teratogenesis, Carcinogenesis, and Mutagenesis 8, no. 2 (1988): 65–79. http://dx.doi.org/10.1002/tcm.1770080202.

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Marianian, A. Yu. "Effects of alcohol on pregnancy and the fetus. the role of preventive measures in daily practice of an obstetrician." Kazan medical journal 95, no. 2 (2014): 287–91. http://dx.doi.org/10.17816/kmj2083.

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Alcohol consumption during pregnancy can cause serious birth defects and developmental disorders. The article reviews scientific literature describing modern conceptions of alcohol-associated teratogenicity. Problems of public awareness of alcohol negative impact on pregnancy and the fetus (particularly by informing women of reproductive age and pregnant women) are raised. Literature review revealed that there is a lack of information on fetal disorders associated with alcohol consumption by the mother. Nowadays, alcohol consumption in Russia is one of the highest in the world (15.8 liters per

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Suryani, A. B. Sutjiatmo, E. Y. Sukandar, I. N. Anisa, and S. N. Vikasari. "Evaluation Teratogenicity of Phyllanthus Acidus (L.) Skeel Leaf Ethanol Extract in Pregnant Wistar Rats." IOP Conference Series: Earth and Environmental Science 1104, no. 1 (2022): 012025. http://dx.doi.org/10.1088/1755-1315/1104/1/012025.

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Abstract The Phyllanthus acidus (L.) Skeels has been used as traditional medicine. It has been proved to have hepatoprotective, anti-inflammatory, antidiabetic, and antioxidant properties. Toxicology data in pregnant women are still unknown. The purpose of this study is to assess the safety of an ethanol extract of Phyllanthus acidus (L.) Skeels leaves (EEPA) on pregnant women and fetuses. The pregnant Wistar rats were divided into five groups: a negative control (vehicle), a positive control (5-fluorouracil 10 mg/kg), and three experiment groups (22.5, 90, and 1000 mg/kg). The extract was giv

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Goldberg, Harold L., and Robyn Nissim. "Psychotropic Drugs in Pregnancy and Lactation." International Journal of Psychiatry in Medicine 24, no. 2 (1994): 129–47. http://dx.doi.org/10.2190/2bf1-0718-we7f-a9f7.

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Objective: This article reviews the literature on the use of psychotropic drugs in pregnancy and lactation. Method: Medline search yielded more than five hundred titles. Articles were reviewed and ninety-one were selected for reference. Results: Fetal physiology and teratogenicity are discussed and the effects of specific drugs on the fetus and newborn are presented. When possible, recommendations for use or non-use are presented. Conclusions: Though no controlled studies have ever been done in pregnant women to truly prove their safety, it appears that most, but not all, current psychotropic

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Sharma, Anju, PJ John, and Pradeep Bhatnagar. "Combination of fluoride and endosulfan induced teratogenicity and developmental toxicity in Swiss albino mice exposed during organogenesis." Toxicology and Industrial Health 35, no. 9 (2019): 604–13. http://dx.doi.org/10.1177/0748233719879312.

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The present investigation was conducted to evaluate the teratogenic and developmental toxicity of fluoride and endosulfan alone and in combination in pregnant Swiss albino mice exposed during the organogenetic period (5–14 days) of gestation. Fluoride (25.1 mg/kg body weight in water) and endosulfan (1.8 mg/kg bw by oral intubation) when administered alone and in combination (fluoride 25.1 mg/kg bw + endosulfan 1.8 mg/kg bw) to pregnant mice caused significant teratogenic effects in developing fetuses. There was no maternal mortality but significant decreases in maternal weight gain and number

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Ősz, Bianca-Eugenia, Ruxandra Ștefănescu, Andreea Sălcudean, George Jîtcă, and Camil-Eugen Vari. "The Risks of “Getting High” on Over-the-Counter Drugs during Pregnancy." Scientia Pharmaceutica 92, no. 1 (2024): 7. http://dx.doi.org/10.3390/scipharm92010007.

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Easy access to over-the-counter (OTC) drugs makes it possible to procure active substances that normally used in therapeutic doses do not raise health problems. The use of high doses of OTC drugs containing codeine, loperamide, pseudoephedrine, diphenhydramine or dimenhydrinate, as well as the use of benzidamine systemically raises concerns regarding the increase in units sold. These drugs are used for recreational or euphorizing purposes, including by young women of childbearing age, psychoactive substance users representing a risk group in terms of the possibility of an unplanned pregnancy.

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Liu, Yong, Xiang Zhu, Feng-ling Yu, et al. "Teratogenicity of Staphylococcus aureus L-forms using a mouse whole-embryo culture model." Journal of Medical Microbiology 62, no. 5 (2013): 677–82. http://dx.doi.org/10.1099/jmm.0.045955-0.

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Our previous studies have suggested that Staphylococcus aureus L-forms are able to pass through the placental barrier of mice from the maternal side to the fetal body and affect fetal growth and development, but little is known about the direct influence of S. aureus L-forms on embryos during the critical period of organogenesis. Mouse embryos at gestational day 8.5 were cultured in vitro for 48 h with 0, 50, 100, 200 or 400 c.f.u. S. aureus L-forms ml−1. At the end of the culture period, the mouse embryos were assessed morphologically for viability, growth and development. Bacteriological and

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M. A .GHAZI ., Dr Zainab. "TERATOGENIC EFFECTS OF CADMIUM EXPERIMENTALLY INDUCED IN RATS." مجلة العلوم والدراسات الإنسانية - كلية الآداب والعلوم – المرج, no. 3 (May 5, 2024): 180–87. http://dx.doi.org/10.37376/jsh.vi3.4907.

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The heavy metal cadmium (Cd) is an environmentally ubiquitouscontaminant, has a potent teratogen in albino rat(40) pregnant females were used inthe teratogenicity investigation. The pregnant females were divided into two equalgroups. G1( Control): Administered distilled water orally on days 7-15 of gestation. G2(Control + ve): Given Cdcl2 orally on days 7-15 of gestation (at 15 mg/Kg) .Morphological, visceral and skeletal abnormalities were examined in our study.showed a decrease in fetal and placenta weight, increase in the number of resorptions, implantation , dead feutes, dwarfism and hemor

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Marchi, Nely Silvia Aragão de, Reinaldo Azoubel, and Waldir Antonio Tognola. "Teratogenic effects of lamotrigine on rat fetal brain: a morphometric study." Arquivos de Neuro-Psiquiatria 59, no. 2B (2001): 362–64. http://dx.doi.org/10.1590/s0004-282x2001000300010.

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A study of the teratogenic activity of an antiepileptic drug - lamotrigine - was carried out in the brain of fetuses of rats who had received the drug. The dosage levels studied corresponded to four times the median effective dose (ED50) in rats. The drug was administered during the organogenesis period. Rats were sacrificed one day prior to term and fetuses were macroscopically examined, weighted and cephalic segments sectioned (Wilson technique), for histological study by stereological analysis, using Merz's grid for drawing and point counts. Cortex, subcortex, ependyma and lateral ventricle

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DEUTCHEU NIENGA, Sorelle, Ferdinand NGOULA, Herve TCHOFFO, Jeamine Laura MABOU NGUEMO, Bertin Narcisse VEMO, and Joseph TCHOUMBOUE. "Evaluation of antidotal potentials of hydroethanolic extract of Spirulina platensis on teratogenicity of Cavia porcellus induced by exposure to lead acetate." Journal of Animal Science and Veterinary Medicine 4, no. 4 (2019): 145–50. http://dx.doi.org/10.31248/jasvm2019.155.

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Lead acetate is a compound that is teratogenic and could cause hazards in pregnant humans and economic loses in livestock. This study aims to evaluate the protective and curative effects of hydroethanolic extract of Spirulina platensis (HESP) on embryo-toxicity in guinea pig exposed to lead acetate. Eighteen females, aged 4 months old and weighing 350±5.3 g were divided into 8 groups of 10 guinea pigs each. The negative control (group 1) received by gavage distilled water and positive control (group 2) was exposed to lead acetate at a dose of 12 mg/kg.bw alone. While Groups 3, 4 and 5 co-expos

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Kalinina, Anastasiia, Maria Semenova, Alexandra Bruter, et al. "Cyclophilin A as a Pro-Inflammatory Factor Exhibits Embryotoxic and Teratogenic Effects during Fetal Organogenesis." International Journal of Molecular Sciences 24, no. 14 (2023): 11279. http://dx.doi.org/10.3390/ijms241411279.

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The precise balance of Th1, Th2, and Th17 cytokines is a key factor in successful pregnancy and normal embryonic development. However, to date, not all humoral factors that regulate and influence physiological pregnancy have been completely studied. Our data here pointed out cyclophilin A (CypA) as the adverse pro-inflammatory factor negatively affecting fetal development and associated with pregnancy complications. In different mouse models in vivo, we demonstrated dramatic embryotoxicity and teratogenicity of increased CypA levels during pregnancy. Using generated transgenic models, we showe

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Aggarwal, P., B. Aggarwal, V. Gupta, and P. Gupta. "AB0350 DRUG SAFETY AND PREGNANCY OUTCOME IN INDIAN PATIENTS WITH RHEUMATOID ARTHRITIS (RA)." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1359.1–1359. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4558.

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BackgroundDue to ethical issues conducting controlled trials to assess safety, teratogenicity of medicines to treat Rheumatoid Arthritis (RA) is not feasible and pregnant women are excluded from drug trials. Hence data concerning safety of arthritis medicines in RA is limited. To our knowledge no study is available from India regarding pregnancy outcome and drug safety in RA patients.ObjectivesAnalyze safety of arthritis medicines and pregnancy outcome in Indian women suffering from RA.MethodsRetrospective analysis of RA women with pregnancy treated at Punjab Rheumatology Immunology Centre, Lu

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Creeley and Denton. "Use of Prescribed Psychotropics during Pregnancy: A Systematic Review of Pregnancy, Neonatal, and Childhood Outcomes." Brain Sciences 9, no. 9 (2019): 235. http://dx.doi.org/10.3390/brainsci9090235.

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This paper reviews the findings from preclinical animal and human clinical research investigating maternal/fetal, neonatal, and child neurodevelopmental outcomes following prenatal exposure to psychotropic drugs. Evidence for the risks associated with prenatal exposure was examined, including teratogenicity, neurodevelopmental effects, neonatal toxicity, and long-term neurobehavioral consequences (i.e., behavioral teratogenicity). We conducted a comprehensive review of the recent results and conclusions of original research and reviews, respectively, which have investigated the short- and long

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Christian, M. S., Stefan Schulte, and Jürgen Hellwig. "Developmental (embryo-fetal toxicity/teratogenicity) toxicity studies of synthetic crystalline lycopene in rats and rabbits." Food and Chemical Toxicology 41, no. 6 (2003): 773–83. http://dx.doi.org/10.1016/s0278-6915(03)00009-7.

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Ponticelli, Claudio, Barbara Zaina, and Gabriella Moroni. "Planned Pregnancy in Kidney Transplantation. A Calculated Risk." Journal of Personalized Medicine 11, no. 10 (2021): 956. http://dx.doi.org/10.3390/jpm11100956.

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Pregnancy is not contraindicated in kidney transplant women but entails risks of maternal and fetal complications. Three main conditions can influence the outcome of pregnancy in transplant women: preconception counseling, maternal medical management, and correct use of drugs to prevent fetal toxicity. Preconception counseling is needed to prevent the risks of an unplanned untimely pregnancy. Pregnancy should be planned ≥2 years after transplantation. The candidate for pregnancy should have normal blood pressure, stable serum creatinine <1.5 mg/dL, and proteinuria <500 mg/24 h. Maternal

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Abdel-Rahman Tawfik, Nouf Bader Alduweesh, Zeinab Abdel-Hameid Mohamed, Abdel Rahman Sayed Sultan, and Heba Ali Abd El-Rahman. "The histopathological effect of diclofenac potassium on maternal and fetal tissues." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 2866–78. http://dx.doi.org/10.26452/ijrps.v11i3.2365.

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Diclofenac (DCF) is one of the most generally utilized non-steroidal antiinflammatory therapies during the world for different diseases curing in post pubertal ladies. Be that as it may, constrained data is accessible with respect to its security during pregnancy and teratogenicity. The present study was done to investigate the histopathological impact of diclofenac potassium (DP) on some vital maternal and fetal tissues, placenta and liver during two different periods of gestation. In this study 30 pregnant rats have been used and divided into 3 groups (ten for each one); group 1 (control), g

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Hussain, Tarique, Bie Tan, Gang Liu, et al. "Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/8254289.

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Early embryonic loss and adverse birth outcomes are the major reproductive disorders that affect both human and animals. The LPS induces inflammation by interacting with robust cellular mechanism which was considered as a plethora of numerous reproductive disorders such as fetal resorption, preterm birth, teratogenicity, intrauterine growth restriction, abortion, neural tube defects, fetal demise, and skeletal development retardation. LPS-triggered overproduction of free radicals leads to oxidative stress which mediates inflammation via stimulation of NF-κB and PPARγtranscription factors. Flav

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Okab, Asia M. I., Amal K. El-Kattan, Maysa F. Salem, and Asmaa R. Azzam. "The potential teratogenicity of atypical antipsychotic drugs olanzapine versus risperidone on the fetuses and placentae of the pregnant female albino rats: Anatomical and histological study." Tanta Medical Journal 53, no. 3 (2025): 386–94. https://doi.org/10.4103/tmj.tmj_49_23.

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Background Increased incidence of psychosis with widespread availability of antipsychotic drugs (olanzapine and risperidone) were observed. Aim This work aimed to assess the potential teratogenicity of atypical antipsychotic drugs, olanzapine versus risperidone, on fetuses and placentae of pregnant female albino rats using anatomical and histological techniques. Materials and methods This experimental study was conducted on 42 healthy adult albino rats. Pregnant rats (n=30) were categorized equally into three categories (n=10 in each); group I (control group), group II received 1.2 mg/rat/day

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Maurya, Khushboo, Mimangsha Dorshon Chakravarty, Chiranjeeb Rabha, Vikas Kumar Roy, and Guruswami Gurusubramanian. "A comprehensive review on reproductive toxicity of fenugreek and its bioactive component diosgenin: A review based on toxicological evidence." Journal of Reproductive Healthcare and Medicine 6 (March 4, 2025): 7. https://doi.org/10.25259/jrhm_29_2024.

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Due to insufficient understanding and medication on the cause of the COVID-19 pandemic, attention toward the daily intake of dietary supplements and nutraceutical compounds has increased globally to improve health and resistance toward pathogens. Despite remarkable advances in the pharmacology industry to discover and formulate various new dietary ingredients in the form of health-boosting and antioxidant food products, fenugreek is one of the most popular herbs during the pandemic due to its strong antioxidant compound, diosgenin. Diosgenin is an active phytosteroid saponin found in fenugreek

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Niggeschulze, Adolf, and Alexander Kast. "Maternal age, reproduction and chromosomal aberrations in Wistar derived rats." Laboratory Animals 28, no. 1 (1994): 55–62. http://dx.doi.org/10.1258/002367794781065717.

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The fertility of rats ranges from one to 18 months. In standard teratogenicity testing young, mature females are used which may not reflect the situation in women above 35 years old. Reproduction among different age groups of Wistar ats (strain Chbb : THOM) was compared at 3, 6, 9, 12, 15 and 18 months. At least 20 virgin females were inseminated per age group. The copulation rate did not differ between the groups. From the maternal age of 12 months, the pregnancy rate was significantly decreased, from the age of 9 months, the litter values were significantly lowered and the resorption rates w

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Mariani, Marco Valerio, Nicola Pierucci, Vincenzo Mirco La Fazia, et al. "Antiarrhythmic Drug Use in Pregnancy: Considerations and Safety Profiles." Journal of Cardiovascular Development and Disease 11, no. 8 (2024): 243. http://dx.doi.org/10.3390/jcdd11080243.

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Pregnancy entails notable physiological alterations and hormonal fluctuations that affect the well-being of both the fetus and the mother. Cardiovascular events and arrhythmias are a major concern during pregnancy, especially in women with comorbidities or a history of arrhythmias. This paper provides an overview of the prevalence, therapies, and prognoses of different types of arrhythmias during pregnancy. The administration of antiarrhythmic drugs (AADs) during pregnancy demands careful consideration because of their possible effect on the mother and fetus. AADs can cross the placenta or be

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Symonds, Jennifer M., Nicole Beauchamp, Takuto Takeuchi, et al. "Toxicological assessment of Euglena gracilis strain Eu029 shows no adverse effects in vivo and in vitro." Toxicology Research and Application 2 (January 1, 2018): 239784731876167. http://dx.doi.org/10.1177/2397847318761672.

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Euglena gracilis is a single-celled organism capable of photosynthesis and heterotrophy. Euglena sp. have long been studied in the laboratory for its metabolic pathways, cell motility, and ease of culture. The safety of E. gracilis strain eu029 (EG029) for use as a food ingredient was assessed in a bacterial reverse mutagenesis assay (Ames), rec assay, in vivo micronucleus assay, acute toxicity study in mice, 13-week toxicology in rats, and a teratology study in mice and rats. EG029 was not genotoxic. The No Observed Adverse Effect Level (NOAEL) in the 13-week study was greater than 1000 mg/kg

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Chandrasekaran, R., DK Giri, and M. Roy Chaudhury. "Embryotoxicity and teratogenicity studies of poly (DL-Lactide-co-Glycolide) microspheres incorporated tetanus toxoid in Wistar rats." Human & Experimental Toxicology 15, no. 4 (1996): 349–51. http://dx.doi.org/10.1177/096032719601500411.

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Tetanus Toxoid loaded biodegradable microspheres (MTT) (poly (DL-Lactide-co-Glycolide) were administered intramuscularly to pregnant Wistar rats from Days 6 to 15 of gestation, at 1, 5 and 10-times the human equivalent dose of TT. Developmental defects in relation to soft tissues and skeleton, weight and sex of live pups and early fetal deaths from treated and control rats were analysed. The findings in treatment groups were comparable to those in the controls. These observations show that MTT was safe for pregnant rats and developing pups.

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Battistoni, M., F. Di Renzo, F. Metruccio, R. Bacchetta, and E. Menegola. "Use of the alternative test R-FETAX (Refined-Frog Embryo Teratogenicity Assay-Xenopus) to evaluate the Fetal Alcohol Spectrum Disorders (FASD)." Reproductive Toxicology 134 (May 2025): 108896. https://doi.org/10.1016/j.reprotox.2025.108896.

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Vandenbroucke, Tineke, Magali Verheecke, Kristel Van Calsteren, Sileny Han, Laurence Claes, and Frédéric Amant. "Fetal outcome after prenatal exposure to chemotherapy and mechanisms of teratogenicity compared to alcohol and smoking." Expert Opinion on Drug Safety 13, no. 12 (2014): 1653–65. http://dx.doi.org/10.1517/14740338.2014.965677.

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Mayur, S.Tekade Nitin W. Pawar Poonam D. Awaghate Jagdish V. Manwar. "An Overview Of Teratogenicity, Encompassing An Investigation Of Birth Abnormalities Resulting From Teratogenic Medications." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1029–42. https://doi.org/10.5281/zenodo.12739615.

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The implementation of this article is to deliver a fast and easy summary of an overview of what we know right now about the human origins and risk factors teratogenic organizational anomalies. Despite the fact that several recent studies looked at supplementary unfavorable conclusions such as birth weight insufficient, fetal mortality, and efficient issues, the structural birth will be the topic of our discussion of abnormalities in this Commentary. According to FDA, we discussed the various classes of teratogenic drugs. The exceedingly challenging issue of delivering optimum therapeutic advan

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Rios, S. S., C. N. Resende, A. B. Peixoto, and E. Araujo Junior. "Treatment of COVID-19 disease in pregnancy and breastfeeding." Sechenov Medical Journal 12, no. 2 (2021): 44–54. http://dx.doi.org/10.47093/2218-7332.2021.12.2.44-54.

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The physiological and anatomical clinical characteristics of pregnant women make them susceptible to complications caused by coronavirus disease (COVID-19). Increased coagulation and risk of thromboembolic phenomena are common during pregnancy; they are further enhanced when associated with a thrombogenic pathology such as in COVID-19. The treatment of COVID-19 is controversial and limited, even for non-pregnant patients. During pregnancy, the options are even more restricted due to the teratogenicity of some drugs and anatomical and physiological difficulties, especially in advanced pregnancy

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