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Journal articles on the topic 'Fetuses; organs'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kosheleva, N. G., and L. B. Zubjitskua. "Pregnancy outcomes, immunomorphologic condition of placenta after arv infection of pregnant woman. Prevention. Treatment." Journal of obstetrics and women's diseases 54, no. 3 (2005): 12–18. http://dx.doi.org/10.17816/jowd81944.

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53 pregnancy outcomes for fetuses and newborns, immunomorphologic condition of placentae and organs of 29 stillborn fetuses were studied. Antigens of viruses A (H1N1 and H2N2), B, RC, AD were detected in placenta and organs of stillborn fetuses. Fixed immune complex, containing C3 complement and IgM, IgA, IgG, was observed in nearly 100 % in placenta and rather rarely in fetus organs. Virus antigens were the same in placenta and fetus organs.

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2

Inage, Yuka, Koki Fujimori, Masaki Takasu, et al. "Fetal Kidney Grafts and Organoids from Microminiature Pigs: Establishing a Protocol for Production and Long-Term Cryopreservation." International Journal of Molecular Sciences 25, no. 9 (2024): 4793. http://dx.doi.org/10.3390/ijms25094793.

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Fetal organs and organoids are important tools for studying organ development. Recently, porcine organs have garnered attention as potential organs for xenotransplantation because of their high degree of similarity to human organs. However, to meet the prompt demand for porcine fetal organs by patients and researchers, effective methods for producing, retrieving, and cryopreserving pig fetuses are indispensable. Therefore, in this study, to collect fetuses for kidney extraction, we employed cesarean sections to preserve the survival and fertility of the mother pig and a method for storing feta

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3

Kupriianova, L., and A. Pakhlivanzade. "Immunohistochemical features of the collagen’ formation in the uterus of fetuses with a gestational term of 21-28 weeks from mothers, whose pregnancy was complicated by preeclampsia of different stage of severity." Journal of Education, Health and Sport 11, no. 9 (2021): 828–40. http://dx.doi.org/10.12775/jehs.2021.11.09.098.

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In the following article we are going to provide the results of research on uterus’ structure in case of fetuses with a gestational term of 21-28 weeks from mothers, whose pregnancy was complicated by PE of different severity stage (15 cases) comparing to one in case of fetuses from mothers with a physiological pregnancy (15 cases). All fetuses have died intranatally as a result of an acute disorder in uterine-placental and uterine-fetal circulation. The research methods: macroscopic, organometric, histological, immunohistochemical, morphometric and statictical. By applying an organometric met

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4

Kupriianova, L., and S. Ivanchenko. "Immunohistological features of the collagen formation in ovaries of fetuses from mothers with a physiological pregnancy on different gestational terms." Journal of Education, Health and Sport 12, no. 2 (2022): 274–84. http://dx.doi.org/10.12775/jehs.2022.12.02.029.

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The comprehensive study on the fetal ovaries allowed us to disclose main features of the collagen synthesis in different organ’s components relatively to the gestational term of fetus. We have studied the ovaries’ structure in case of fetuses, who died both antenatally and intranatally. The mothers of fetuses, according to the medical documentation, were healthy. As a reason of the fetuses death we can name an acute violation of the utero-placental as well as placental-fetal circulation. According to the specific features of the organs’ development, all fetuses were divided into groups: 21-28

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5

Poliasnyi, V., and L. Kupriianova. "Immunohistochemical features of the fallopian tubes’ structure in case of fetuses with a gestational term of 21-28 weeks from mothers with a chronic infection of the lower genital tracts." Journal of Education, Health and Sport 11, no. 8 (2021): 445–56. http://dx.doi.org/10.12775/jehs.2021.11.08.050.

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In the following article we are disclosing immunohistochemical features of the fallopian tubes’ structure in case of fetuses with a gestational term of 21-28 weeks. We have studied the structure of organs of 15 fetuses from mothers with a chronic infection of the lower genital tracts (HILGT) (the group of comparison) relatively to one in case of 15 fetuses from mothers with a physiological pregnancy (the main group). All fetuses had a gestational term of 21-28 weeks and had died intranatally as a result of an acute disorder of uterine-placental circulation. Methods of reearch: organometric, hi

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6

Jawor, Paulina, John F. Mee, and Tadeusz Stefaniak. "Role of Infection and Immunity in Bovine Perinatal Mortality: Part 2. Fetomaternal Response to Infection and Novel Diagnostic Perspectives." Animals 11, no. 7 (2021): 2102. http://dx.doi.org/10.3390/ani11072102.

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Bovine perinatal mortality due to infection may result either from the direct effects of intrauterine infection and/or the fetal response to such infection, leading to the fetal inflammatory response syndrome (FIRS). Both intrauterine infection and FIRS, which causes multi-organ damage and involution of immune organs, compromise fetal survivability, sometimes fatally. Organ injury associated with FIRS may, in addition to causing fetal mortality, irreversibly compromise extrauterine adaptation of the neonate, a recognized problem in human fetuses. Diagnosis of intrauterine infection and of FIRS

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7

RANDALL, G. C. B. "EFFECT OF HYPOPHYSECTOMY ON BODY AND ORGAN WEIGHTS AND SUBSEQUENT DEVELOPMENT IN THE FETAL PIG." Canadian Journal of Animal Science 69, no. 3 (1989): 655–61. http://dx.doi.org/10.4141/cjas89-079.

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The effect of hypophysectomy on fetal growth and development was studied in 45 fetuses in which the pituitary had been destroyed by electrocoagulation between 68 and 84 d of gestation, and in 35 control littermates. Hypophysectomized fetuses were significantly heavier than their intact litter mates (1203 g vs. 1057 g; P < 0.05), were more edematous and had visible body fat stores. Fetuses hypophysectomized before 70 d of gestation were hairless and myxedematous, whereas in those hypophysectomized after day 80 the body surface either was similar to that of intact litter mates or had mild hyp

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8

Poliyasnyi, V. O., and L. S. Kupriianova. "Immunuhistochemical features of the ovaries’ structure in case of fetuses with a gestational term of 21-28 weeks from mother, whose pregnancy was complicated by chronic infections of lower genital tracts." Journal of Education, Health and Sport 11, no. 5 (2021): 246–61. http://dx.doi.org/10.12775/jehs.2021.11.05.026.

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The following article presents results of the complex research on postulation of immunohistochemical features of the ovaries’ structure in case of fetuses with a gestational term of 21-28 weeks from mothers with HILGT comparing to ones in case of fetuses from mothers with a physiological pregnancy. The materials of the research are: 25 fetuses from mothers with HILGT as well as 25 fetuses from mothers with physiological pregnancy. All fetuses had died antenatally and inranatally, as a result of violation of uteroplacental and umbilical-uterine circulation. Research methods: macroscopic, organo

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9

Silva, Flávia Helena Pereira, Juliana Torres Tomazi Fritzen, Julia Raisa Ximenes Figueiredo, et al. "Transplacental Infections Associated with Macavirus in Aborted Bovine Fetuses." Microorganisms 12, no. 8 (2024): 1608. http://dx.doi.org/10.3390/microorganisms12081608.

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The Macavirus genus, Gammaherpesvirinae subfamily, Herpesviridae family, contains ovine gammaherpesvirus 2 (OvGHV2), the cause of sheep-associated malignant catarrhal fever (SA-MCF). Members of the Macavirus genus associated with the development of malignant catarrhal fever (MCF) in their respective hosts share the 15A antigenic epitope, are conserved within the DNA polymerase gene and are collectively referred to as the malignant catarrhal fever virus (MCFV) complex. The ability of MCFV and/or OvGHV2 to produce abortions in ruminants is currently unknown, with little documentation of infectio

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10

FARNWORTH, E. R., and J. K. G. KRAMER. "CHANGES IN THE LIPID COMPOSITION OF THE INTERNAL ORGANS OF FETAL PIGS FROM SOWS FED DIFFERENT DIETARY FATS." Canadian Journal of Animal Science 69, no. 2 (1989): 441–48. http://dx.doi.org/10.4141/cjas89-049.

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Heart, liver, lungs and kidneys were taken from fetal pigs at 57, 85, and 110 d of gestation. Sows had been fed either a no-fat-added control diet or one with either added tallow (high in saturated fatty acids) or added soybean oil (high in unsaturated fatty acids). Maternal diet had no significant effect on organ weight, organ total lipid, or the percent composition of nine lipid classes in the total lipid extracts. Significant changes in composition were found as the fetuses developed, and differences in composition were also evident among tissues. The fatty acid composition of the triglycer

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11

Nuzhat, Ayesha. "Anatomy of Inferior Mesenteric Artery in Fetuses." Scientifica 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/5846578.

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Aim. To analyze Inferior Mesenteric Artery in fetuses through its site of origin, length, diameter, and variation of its branches.Method. 100 fetuses were collected from various hospitals in Warangal at Kakatiya Medical College in Andhra Pradesh, India, and were divided into two groups, group I (second-trimester fetuses) and group II (third-trimester fetuses), followed by dissection.Result.(1) Site of Origin. In group I fetuses, origin of Inferior Mesenteric Artery was at third lumbar vertebra in 33 out of 34 fetuses (97.2%). In one fetus it was at first lumbar vertebra, 2.8%. In all group II

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12

Grigoriev, Vasily S. "MORPHOFUNCTIONAL DEVELOPMENT OF LYMPHOID HEMATOPOIESIS ORGANS IN PIGS DURING THE PRENATAL PERIOD." Bulletin Samara State Agricultural Academy 8, no. 2 (2023): 87–94. https://doi.org/10.55170/19973225_2023_8_2_87.

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The aim of the research is to increase the cellular and humoral immunity of productive animals. Histogenesis and functional formation of thymus and lymph nodes in piglets in the prenatal period were studied. It has been established that the thymus, as the central organ of the immune system, is formed in the fetus of pigs from the age of 30 days. The mass of the thymus gland during this period is 30.30±0.24 mg, length – 1.20±0.04 cm, width – 0.3±0.01 cm. In a 100-day–old fetus, the mass and length of the thymus gland significantly increase by 4.5 times, the width by 2 times. In 50-day-old fetus

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13

Jansen, A. H., J. Belik, S. Ioffe, and V. Chernick. "Control of organ blood flow in fetal sheep during normoxia and hypoxia." American Journal of Physiology-Heart and Circulatory Physiology 257, no. 4 (1989): H1132—H1139. http://dx.doi.org/10.1152/ajpheart.1989.257.4.h1132.

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The role of peripheral chemoreceptors in the circulatory adaptation to hypoxia and the effects of rapid-eye-movement (REM) and non-REM (NREM) sleep and breathing activity on organ blood flow were assessed in fetal sheep. Blood flow was measured with isotope-labeled microspheres on intact, vagotomized (VX), and sinoaortic-denervated (SAD) fetuses. Denervation did not change the biventricular cardiac output (Biv. CO) or organ blood flows during normoxia. In intact fetuses the blood flow was increased during hypoxemia in brain, adrenals, and heart but not in kidneys, skeletal muscles, or placenta

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14

Grebinichenko, G. O., I. Yu Gordienko, I. S. Luk'yanova, O. M. Dzyuba, and G. F. Medvedenko. "The state of the provisional organs in the fetus with vital and lethal anomalies (literature review)." UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS, no. 4(88) (December 30, 2021): 44–51. http://dx.doi.org/10.15574/pp.2021.88.44.

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Provisional organs (placenta, umbilical cord, amniotic membranes, amniotic fluid) play a significant role during pregnancy. Their normal morpho3functional state is an important condition for normal development and well3being of the fetus, as well as for uncomplicated course of pregnancy. Congenital malformations (CM) and chromosomal abnormalities are major causes of perinatal morbidity and mortality. For fetuses with malformations, dysfunction of the provisional organs (PO) can become critical and affect survival. Expert correct examination of PO during a comprehensive prenatal examination can

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15

Gurevich, Pavel, Herzl Ben-Hur, Sergio Szvalb, Moisey Moldavsky, and Itshak Zusman. "Lymphoid–Epithelial Secretory Immune System in Human Fetuses in the Second Trimester of Gestation." Pediatric and Developmental Pathology 5, no. 1 (2002): 22–28. http://dx.doi.org/10.1007/s10024-001-0088-0.

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The development of the secretory immune system (SIS) in the respiratory, digestive, and urogenital tracts and other organs of fetuses in the second trimester of gestation is described. Tissues of all internal organs of human fetuses ( n = 36) that had died between 13 and 25 weeks of gestation were studied immunohistochemically for the presence of secretory component (SC), J chain, IgA, IgM, IgG, macrophages, and different subsets of lymphocytes. We found protein elements of the SIS in fetuses during the entire second trimester in the epithelium of the digestive, respiratory, and urinary tracts

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16

Polyasnyi, V. O., and L. S. Kupriianova. "Immunohistochemical features of the structure of fetuses’ uterus with a gestational term of 21-28 weeks from mothers, whose pregnancy is complicated by chronic infection of the lower genital tract." Journal of Education, Health and Sport 11, no. 2 (2021): 230–45. http://dx.doi.org/10.12775/jehs.2021.11.02.023.

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The relevance of the following article is prescribed by the growing number of perinatal mortality and morbidity among newborns due to the mother’s chronic infection of the lower genital tract (HILGT). It is commonly known, that HILGT contributes to the delay of the fetal development likewise is often manifested by the violation of internal organs and systems implementation. One of the most acute topic is the the fetus’ reproductive system in ther early gestation terms. However, the immunohistochemical features of the fetuses’ uterus structure with the gestational term of 21-28 weeks from mothe

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17

Trahair, Jeff F., and Per T. Sangild. "Fetal organ growth in response to oesophageal infusion of amniotic fluid, colostrum, milk or gastrin-releasing peptide: a study in fetal sheep." Reproduction, Fertility and Development 12, no. 2 (2000): 87. http://dx.doi.org/10.1071/rd00024.

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The hypothesis of the present study was that the infusion of the biological fluids to which the develop-ing gut is normally exposed (i.e. amniotic fluid, colostrum, milk) and a single growth factor (gastrin-releasing peptide), which is found in high concentrations in fetal fluids and milk, could ameliorate the altered growth induced by the elimination of swallowed input secondary to ligation of the oesophagus. At 108–110 days of gestation the fetal oesophagus was ligated and a catheter inserted towards the stomach (32 fetuses). At 117–119 days of gestation saline (n = 5), amniotic fluid (n = 5

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18

Yamanaka, Shuichiro, Yatsumu Saito, Toshinari Fujimoto, et al. "Kidney Regeneration in Later-Stage Mouse Embryos via Transplanted Renal Progenitor Cells." Journal of the American Society of Nephrology 30, no. 12 (2019): 2293–305. http://dx.doi.org/10.1681/asn.2019020148.

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BackgroundThe limited availability of donor kidneys for transplantation has spurred interest in investigating alternative strategies, such as regenerating organs from stem cells transplanted into animal embryos. However, there is no known method for transplanting cells into later-stage embryos, which may be the most suitable host stages for organogenesis, particularly into regions useful for kidney regeneration.MethodsWe demonstrated accurate transplantation of renal progenitor cells expressing green fluorescent protein to the fetal kidney development area by incising the opaque uterine muscle

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Korzhavov, Sherali Oblakulovich Khairitdinov Boburshokh Burkhonovich Rakhimov Shakhriyor Azamatovich Naimova Fotima Muinjonovna. "MICROSCOPICAL INDICES OF THYMUS IN NEWBORN FETUSES." EURASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES 2, no. 9 (2022): 4–10. https://doi.org/10.5281/zenodo.7050454.

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The formation of the immunity system in ontogenesis, in particular the central organ of its thymus, is determined by the combination of the relationship between mother and fetus and the course of the period of early adaptation of offspring to conditions outside uterine life. As a rule, in early postnatal ontogenesis, the immune system is in a transient state and continues to form under the influence of various influences of external factors. The uncomplicated course of pregnancy largely determines the normal course of the immunological relationship between mother and fetus, and determines the

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20

Banks, Gloria J. "Legal & Ethical Safeguards: Protection of Society's Most Vulnerable Participants in a Commercialized Organ Transplantation System." American Journal of Law & Medicine 21, no. 1 (1995): 45–110. http://dx.doi.org/10.1017/s0098858800010212.

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Legal and ethical questions regarding existing organ transplant procurement policies and practices are numerous and unsettling. They arise because transplantable organs are scarce. The scarcity of such organs has been the hue and cry of several medical and legal scholars. For example, the scarcity creates competition among those who wait, necessitating equitable organ allocation procedures and guidelines. Medical obstacles surround the determination of when, how, and on whom such procedures can be performed successfully. Other obstacles range from finding a suitable donor for proper “matching”

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Poudel, Rajan, I. Caroline McMillen, Stacey L. Dunn, Song Zhang, and Janna L. Morrison. "Impact of chronic hypoxemia on blood flow to the brain, heart, and adrenal gland in the late-gestation IUGR sheep fetus." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308, no. 3 (2015): R151—R162. http://dx.doi.org/10.1152/ajpregu.00036.2014.

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In the fetus, there is a redistribution of cardiac output in response to acute hypoxemia, to maintain perfusion of key organs, including the brain, heart, and adrenal glands. There may be a similar redistribution of cardiac output in the chronically hypoxemic, intrauterine growth-restricted fetus. Surgical removal of uterine caruncles in nonpregnant ewe results in the restriction of placental growth (PR) and intrauterine growth. Vascular catheters were implanted in seven control and six PR fetal sheep, and blood flow to organs was determined using microspheres. Placental and fetal weight was s

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22

Sliepov, O. K., N. Y. Skripchenko, O. P. Ponomarenko, and K. L. Znak. "Prevention of pathological changes of eventerated organs in gastroschisis in fetuses and newborns." UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS, no. 3(99) (September 28, 2024): 104–8. http://dx.doi.org/10.15574/pp.2024.3(99).104108.

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The primary cause of unsatisfactory outcomes in the treatment of gastroschisis (GS) is the pathological changes in eviscerated organs and their consequences. One preventive method against these pathological changes is the premature delivery of pregnant women with fetal GS, either by physiological means or cesarean section. Aim - to analyze and develop preventive measures for pathological changes in eviscerated organs in GS by optimizing the delivery timing and method in pregnant women, to improve outcomes in fetuses and neonates. Materials and methods. The study examined the impact of delivery

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23

Tsyhykalo, O. V., and R. R. Dmytrenko. "Peculiarities of 3D reconstruction of the rudiments of skull bones in the prenatal period of human ontogenesis." Morphologia 17, no. 3 (2023): 131–39. https://doi.org/10.26641/1997-9665.2023.3.131-139.

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Background. 3D reconstruction of microscopic structures is a valuable method of morphological research of the early period of human ontogenesis. Much smaller than that of an adult organism, the size of the organs and structures of fetuses makes it technically possible to embedding them into a single paraffin block and reconstruct them in serial sections in anatomical continuity to study the form and syntopy. Objective is to find out the effectiveness of 3D reconstruction methods of bone tissue in the prenatal period of human development. Methods. The research was carried out on 6 series of con

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Maroun, Lisa Leth, and Niels Graem. "Autopsy Standards of Body Parameters and Fresh Organ Weights in Nonmacerated and Macerated Human Fetuses." Pediatric and Developmental Pathology 8, no. 2 (2005): 204–17. http://dx.doi.org/10.1007/s10024-004-7084-0.

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Standards for body parameters and organ weights are important tools in fetal and perinatal pathology. Previously there has been only a weak emphasis on the effect of maceration on dimensions and weights. This study provides autopsy standards for body weight, body dimensions, and fresh organ weights for nonmacerated fetuses and for mildly, moderately, and markedly macerated fetuses at 12 to 43 weeks of gestation. Cases were selected from a consecutive series of 1800 fetal and perinatal autopsies. Cases with malformations, hydrops, infection, or chromosomal abnormality, fetuses from multiple bir

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Hwang, In-Sul, Mi-Ryung Park, Hae-Sun Lee, et al. "Developmental and Degenerative Characterization of Porcine Parthenogenetic Fetuses during Early Pregnancy." Animals 10, no. 4 (2020): 622. http://dx.doi.org/10.3390/ani10040622.

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The difference between early pregnancy and delivery rate is quite large in assisted reproduction techniques (ARTs), including animal cloning. However, it is not clear why the implanted fetuses aborted after the early pregnancy stage. In the present study, we tried to evaluate the developmental and morphological characteristics of porcine parthenogenetically activated (PA) embryos or fetuses by electric stimulation during the early pregnancy period. The implanted PA and artificially inseminated (AI) embryos and fetuses were collected at day 26 and 35 after embryo transfer, respectively. The dev

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YuTing, LiangSiying, and YuDongyi. "The Strategic Study in the Prenatal Diagnosis of a Chimeric Trisomy 15 Fetus." International Journal of Sciences Volume 7, no. 2018-12 (2018): 70–73. https://doi.org/10.5281/zenodo.3350519.

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Objectives: To explore the utility of amniotic cell karyotype analysis in combined with chromosome microarray analysis in prenatal diagnosis. Methods: Chromosome microarray analysis (CMA) and amniotic cell karyotype analysis were accepted by a pregnant woman who carried a fetus with chromosome 15 aneuploidy suggested by non-invasive prenatal test (NIPT). Later on, the woman chose abortion because ultrasound detection had diagnosed that the fetus manifested hypospadias, long bone dysplasia, and abnormal vasa umbilicalis. The placenta, aborted fetus's tissues and organs were collected and verifi

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Chen, Una, and Hoyan Mok. "Development of Mouse Embryonic Stem (ES) Cells: IV Differentiation to Mature T and B Lymphocytes after Implantation of Embryoid Bodies Into Nude Mice." Developmental Immunology 4, no. 2 (1995): 79–84. http://dx.doi.org/10.1155/1995/52962.

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Mouse embryonic stem (ES) cells in culture can differentiate into late stages of many lineage-committed precursor cells. Under appropriate organ-culture conditions, ES cels differentiate into lymphoidlike cells at a stage equivalent to lymphoid cells found in fetal liver. These hematopoietic precursors are located in cup-shaped structures found in some embryoid bodies; we called such embryoid bodies “ES fetuses.” In this study, we have followed the maturation of hematopoietic cells after implantation of ES fetuses into nude mice for 3 weeks. ES-cell-derived lymphoid cells-pre-B cells, mature B

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Odendaal, Lieza, Sarah J. Clift, Geoffrey T. Fosgate, and A. Sally Davis. "Ovine Fetal and Placental Lesions and Cellular Tropism in Natural Rift Valley Fever Virus Infections." Veterinary Pathology 57, no. 6 (2020): 791–806. http://dx.doi.org/10.1177/0300985820954549.

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Infection with Rift Valley fever phlebovirus (RVFV) causes abortion storms and a wide variety of outcomes for both ewes and fetuses. Sheep fetuses and placenta specimens were examined during the 2010–2011 River Valley fever (RVF) outbreak in South Africa. A total of 72 fetuses were studied of which 58 were confirmed positive for RVF. Placenta specimens were available for 35 cases. Macroscopic lesions in fetuses were nonspecific and included marked edema and occasional hemorrhages in visceral organs. Microscopically, multifocal hepatic necrosis was present in 48 of 58 cases, and apoptotic bodie

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Korjavov, Sherali Oblakulovich, and Latofat Murodillaevna Kurbanova. "MORPHOLOGICAL AND MICROSCOPICAL PARAMETRES OF THYMUS IN NEWBORN FETUSES." МЕДИЦИНА, ПЕДАГОГИКА И ТЕХНОЛОГИЯ: ТЕОРИЯ И ПРАКТИКА 2, no. 4 (2024): 18–28. https://doi.org/10.5281/zenodo.10912596.

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The formation of the immunity system in ontogenesis, in particular the central organ of its thymus, is determined by the combination of the relationship between mother and fetus and the course of the period of early adaptation of offspring to conditions outside uterine life. As a rule, in early postnatal ontogenesis, the immune system is in a transient state and continues to form under the influence of various influences of external factors. The uncomplicated course of pregnancy largely determines the normal course of the immunological relationship between mother and fetus, and determines the

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30

Matsunari, H., K. Nakano, T. Kanai, et al. "26 IN VIVO EXOGENIC ORGAN GENERATION WITH ORGANOGENESIS-DISABLED CLONED PIGS AS A PLATFORM." Reproduction, Fertility and Development 26, no. 1 (2014): 127. http://dx.doi.org/10.1071/rdv26n1ab26.

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The generation of organs from pluripotent stem cells (PSC) is one of the ultimate goals of regenerative medicine. We have demonstrated that functional organs can be generated in vivo from xenogenic PSC in the body of organogenesis-disabled mice using blastocyst complementation. To apply this principle in generating human organs, a technical platform using large non-rodent mammals is essential. The aim of the present study was to establish a blastocyst complementation system using cloned pig embryos. We generated transgenic-cloned pigs with an apancreatic phenotype via the overexpression of Hes

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Vazquez, Jessica, Logan Keding, Michelle R. Koenig, et al. "Fetal Tissues Reflect Decidual-Placental Inflammation." Journal of Immunology 210, no. 1_Supplement (2023): 69.07. http://dx.doi.org/10.4049/jimmunol.210.supp.69.07.

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Abstract Maternal inflammation can negatively impact the development of the fetus, leading to long term adverse health outcomes. We previously reported that injection of Tisseel (surgical glue) into the maternal-fetal interface led to necrosis and inflammation skewing the peripheral fetal immunome into a pro-inflammatory state. Here, we extend those observations and report that decidual inflammation leads to similar outcomes in fetal organs. Tisseel or saline (n = 3) was injected directly into the placenta of pregnant (~GD90) rhesus macaques. C-sections were performed at ~GD150. Fetal tissues

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McNeil, Christopher J., Margaret O. Nwagwu, Angela M. Finch та ін. "Glucocorticoid exposure and tissue gene expression of 11β HSD-1, 11β HSD-2, and glucocorticoid receptor in a porcine model of differential fetal growth". Reproduction 133, № 3 (2007): 653–61. http://dx.doi.org/10.1530/rep.1.01198.

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Glucocorticoids play a critical role in fetal development, but inappropriate exposure is associated with reduced fetal growth. We investigated cortisol exposure and supply in a porcine model of differential fetal growth. This model compares the smallest fetus of a litter with an average-sized sibling at three stages of gestation. At day 45, small fetuses had reduced plasma cortisol (16.8 ± 3.4 ng/ml) relative to average fetuses (34.4 ± 3.4 ng/ml, P < 0.001). At day 65 levels had reduced in small and average fetuses to similar concentrations (5.7 ± 1.0 vs 4.8 ± 0.5 ng/ml, P = 0.128). By day

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Pinto, Ana Paula, Flávia B. Bacha, Bethania S. Santos, et al. "Sheep abortion associated with Neospora caninum in Mato Grosso do Sul, Brazil." Pesquisa Veterinária Brasileira 32, no. 8 (2012): 739–42. http://dx.doi.org/10.1590/s0100-736x2012000800010.

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Canids are the main hosts of Neospora caninum, but cattle, (sheep, goats and horses may serve as intermediary hosts. N. caninum infection of pregnant intermediary hosts may provoke abortion and neonatal infections. This study is the first to report lamb abortion associated with N. caninum in Mato Grosso do Sul. Epidemiological data were obtained from interviews with sheep producers. For microscopic examination, fragments of different organs removed from 4 sheep fetuses, aborted and necropsied, were fixed in 10% formaldehyde, embedded in paraffin and subjected to the hematoxylin-eosin staining

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Fernández, Miguel, Ueli Braun, Sandra Frei, Matthias Schweizer, and Monika Hilbe. "Border Disease Virus Infection of Bovine Placentas." Veterinary Pathology 55, no. 3 (2018): 425–33. http://dx.doi.org/10.1177/0300985817754123.

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Subsequent to a previous study of border disease virus (BDV) horizontal transmission from a persistently BDV-infected calf to 6 seronegative pregnant heifers, the heifers were slaughtered 60 days after exposure to the infected calf, and their fetuses and placentas were examined. Immunohistochemical examination of fetal organs and placenta showed positive labeling of moderate intensity for pestivirus antigen in 3 of 6 heifers. BDV infection in these 3 animals was confirmed by the detection of BDV RNA in different organs using reverse transcription quantitative polymerase chain reaction. In the

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Aymée, Luiza, Maria Isabel Nogueira Di Azevedo, Luiza Reis, et al. "Unconventional Sites for Diagnosis of Leptospirosis in Bovine Anicteric Fetuses." Animals 13, no. 18 (2023): 2832. http://dx.doi.org/10.3390/ani13182832.

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Background: Bovine leptospirosis is an important reproductive disease and abortion is a major sign, leading to economic impacts. Due to its multifactorial etiology, the proper diagnosis of the cause of the abortion is crucial. Necropsy of the fetuses followed by molecular analysis is recommended for diagnosis, and the investigation mainly occurs in the kidneys and liver. This study aimed to analyze unconventional sites for the presence of leptospiral DNA in bovine anicteric aborted fetuses. Methods: Five fetuses of the same herd were received for necropsy and diagnosis. Conventional lipL32-PCR

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Martín, N. P., P. R. Kenyon, P. C. H. Morel, et al. "Ewe nutrition in early and mid- to late pregnancy has few effects on fetal development." Animal Production Science 52, no. 7 (2012): 533. http://dx.doi.org/10.1071/an11246.

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Maternal nutrition affects fetal development, with potential lifelong consequences. The study reported here compared the anatomical development (dimensions and organs) of twin fetuses at Day 140 of gestation, from 58 twin-bearing ewes fed at one of three different nutritional treatments in early pregnancy [Day 21–50, Low (LD21–50) versus Medium (MD21–50) versus High (HD21–50)] and one of two different nutritional treatments in mid- to late pregnancy (Day 50–140, Medium (MD50–140) versus High (HD50–140)]. There were no effects (P > 0.05) of either early or mid- to late pregnancy nutrition on

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Stewart, R. E. A., B. E. Stewart, D. M. Lavigne, and G. W. Miller. "Fetal growth of Northwest Atlantic harp seals, Phoca groenlandica." Canadian Journal of Zoology 67, no. 9 (1989): 2147–57. http://dx.doi.org/10.1139/z89-305.

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Reproductive organs, fetuses, and newborn pups of Northwest Atlantic harp seals (Phoca groenlandica) were collected from 1977 to 1984. These data were used to describe development and fetal growth in terms of biomass and energy, and to estimate the timing of gestational events. The mean pupping date in the Gulf of St. Lawrence was March 2. After the pups were weaned, females mated and conceived around March 12–14. Suspended development of the embryo lasted until early June and implantation took place in August. Fetal mass was more useful in assessing fetal growth than were linear body measurem

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Aleksenko, N. "Trendelenburg's position with an elevated pelvis as a position for gynecological examination." Journal of obstetrics and women's diseases 5, no. 5 (2020): 456–57. http://dx.doi.org/10.17816/jowd55456-457.

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da Costa Barnabé, Nathanael Natércio, Rafael Rodrigues Soares, Deivyson Kelvis Silva Barros, et al. "The Role of Transplacental Infection in Leptospira spp. Epidemiology in Cattle in Caatinga Biome, Brazil." Microorganisms 12, no. 6 (2024): 1044. http://dx.doi.org/10.3390/microorganisms12061044.

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Leptospirosis is an infectious disease that affects domestic animals, wild animals, and humans. It represents a public health problem and has an important economic impact on livestock. This study aims to investigate the importance of genital and transplacental infection in the epidemiology of leptospirosis in cows maintained in Caatinga biome conditions, Northeastern Brazil, as well as reporting organs colonized by Leptospira spp. in embryos and fetuses. Blood, urinary tract (urine, bladder, and kidney), and reproductive tract (vaginal fluid, uterus, uterine tube, ovary, and placenta) samples

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Lieshchova, M. A., A. V. Oliyar, D. D. Bilyi, et al. "Dynamics of lymph nodes weight characteristics in cattle during the prenatal period of their ontogenesis." Theoretical and Applied Veterinary Medicine 8, no. 4 (2020): 283–88. http://dx.doi.org/10.32819/2020.84042.

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In lymph nodes, as peripheral organs of the immune system, the patterns of their growth and development are unique in many ways, especially during the prenatal period of ontogenesis. The changes in the absolute and relative mass of lymph nodes in 66 bovine fetuses of different gestational ages (2–9 months) were studied. The weight of the fetuses and organs was determined with an accuracy of 0.001 g. According to the indicators of weight, body length, and the degree of development of the fetal skin derivatives, their age was established. It was found that in the first third of the fetal period

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Yang, Jilin, and Stephen C. Cunnane. "Quantitative measurements of dietary and [1-14C]linoleate metabolism in pregnant rats: specific influence of moderate zinc depletion independent of food intake." Canadian Journal of Physiology and Pharmacology 72, no. 10 (1994): 1180–85. http://dx.doi.org/10.1139/y94-167.

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Our objective was to investigate whether the effects of moderate zinc deficiency on metabolism of linoleate during pregnancy could be distinguished from the effects of low food intake. Rats were force-fed an isoenergetic zinc-deficient (3.2 mg/kg) or control (26.4 mg/kg) semiliquid diet during the second half of pregnancy. Fatty acid quantity and composition in both maternal and fetal organs were analyzed at term. Recovery of 14C in lipid- and water-soluble metabolites from orally injected [1-14C]linoleate was also studied. After 10 days of gavaging identical amounts of the diet, zinc-deficien

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Bezerra, Mauro J. G., Jefferson A. L. O. Cruz, Eugênio S. Kung, et al. "Occurrence of Toxoplasma gondii DNA in sheep naturally infected and slaughtered in abattoirs in Pernambuco, Brazil." Pesquisa Veterinária Brasileira 34, no. 4 (2014): 329–31. http://dx.doi.org/10.1590/s0100-736x2014000400005.

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The aim of the present study was to assess the occurrence of antibodies to Toxoplasma gondii and to detect genomic DNA of the parasite in the reproductive organs, fetuses and fetal membranes of sheep in slaughterhouses in the state of Pernambuco, Brazil. The Indirect Immunofluorescence technique (IFA) was used for screening. The Polymerase Chain Reaction (PCR) was used to detect DNA of T. gondii in the animals that were positive in the serology. In the serology, 13/50 samples were positive and genomic DNA of T. gondii was detected in one uterus, tube, ovary, placenta and fetus (heart, brain an

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S. M, Amin F. A. "Prenatal Study of Testes Growth and Histological Development 1- Fetal Sheep." Iraqi Journal of Veterinary Medicine 34, no. 1 (2010): 191–200. http://dx.doi.org/10.30539/iraqijvm.v34i1.679.

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This study was conducted on 200 samples of females Karadi sheep genitalia contains 207 fetuses . These samples were collected from slaughter house in Sulaimani reigion during the period from June 2007 to the end of May 2008. Sheep genitalia consisted of 193(96.5%) single and 7(3.5%) twin fetuses, amonge them 122 (58.92%)and 84(41.06) were in the right and left horns ,respectively. The genitalia that contain fetuses with clear external sex organs was 141, of these 74 male and 67 female fetuses different Crown Rump Length (CRL), while 66 fetus their sex could diagnosis after abdominal opened. Th

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Loo, Christine K. C., Elizabeth M. Algar, Diane J. Payton, Joanna Perry-Keene, Tamara N. Pereira, and Grant A. Ramm. "Possible Role of WT1 in a Human Fetus with Evolving Bronchial Atresia, Pulmonary Malformation and Renal Agenesis." Pediatric and Developmental Pathology 15, no. 1 (2012): 39–44. http://dx.doi.org/10.2350/11-03-0997-oa.1.

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The association of peripheral bronchial atresia and congenital pulmonary airway malformation (CPAM) has recently been recognised, but the pathology of the lesions evolving together has not been described. We present autopsy findings in a 20 week fetus showing areas of peripheral bronchial destruction and airway malformation consistent with developing CPAM in the right lung supporting a causal relationship between these lesions. This fetus also had congenital heart defect, bilateral renal agenesis and syndactyly. We identified another fetus from our autopsy files, with bilateral renal agenesis,

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Burkov, P. V., M. A. Derkho, M. B. Rebezov, and P. N. Scherbakov. "Circovirus as a factor controlling the effectiveness of pregnancy in sows." Agrarian science 1, no. 8 (2023): 27–35. http://dx.doi.org/10.32634/0869-8155-2023-373-8-27-35.

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The results of a microscopic examination of the internal organs of virally aborted fetuses are presented in order to determine the causes of reproductive losses in conditions of subclinical circovirus infection in sows. The material of the study was the tissues of the liver, placenta, umbilical cord, spleen and brain of abortion fetuses of sows whose pregnancy was interrupted in the last trimester of pregnancy. They had clinical signs of diseases associated with PCV-2 infection. It has been established that the PCV-2 virus has the ability to penetrate the feto-placental barrier from the mother

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Lopushniak, Lesia Ya, Тatiana V. Khmara, Оleh М. Boichuk, Mariana A. Ryznychuk, Leonid V. Shvyhar, and Mariana I. Kryvchanska. "FETAL ANATOMY OF PARATHYROID GLANDS." Wiadomości Lekarskie 73, no. 1 (2020): 52–57. http://dx.doi.org/10.36740/wlek202001109.

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The aim: To study the forms of anatomical variability of the external structure of the upper and lower parathyroid glands in the fetal period of human ontogenesis. Materials and methods: The study involved 48 specimens of human fetuses with 81,0-375,0 mm of crown-rump length (CRL). The study was conducted by means of macromicroscopic preparation, morphometry and variation statistics method. Results: The age and individual anatomical variability, complex way of development and formation of synotopic embryotropographic correlations of the upper and lower parathyroid glands in the prenatal period

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Suryani, A. B. Sutjiatmo, E. Y. Sukandar, I. N. Anisa, and S. N. Vikasari. "Evaluation Teratogenicity of Phyllanthus Acidus (L.) Skeel Leaf Ethanol Extract in Pregnant Wistar Rats." IOP Conference Series: Earth and Environmental Science 1104, no. 1 (2022): 012025. http://dx.doi.org/10.1088/1755-1315/1104/1/012025.

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Abstract The Phyllanthus acidus (L.) Skeels has been used as traditional medicine. It has been proved to have hepatoprotective, anti-inflammatory, antidiabetic, and antioxidant properties. Toxicology data in pregnant women are still unknown. The purpose of this study is to assess the safety of an ethanol extract of Phyllanthus acidus (L.) Skeels leaves (EEPA) on pregnant women and fetuses. The pregnant Wistar rats were divided into five groups: a negative control (vehicle), a positive control (5-fluorouracil 10 mg/kg), and three experiment groups (22.5, 90, and 1000 mg/kg). The extract was giv

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D. V. Proniaiev, R. Ye. Bulyk та O. P. Kuchuk. "СHARACTERISTICS OF THE UTERUS IN THE FETAL PERIOD: TOPOGRAPHIC AND MORPHOMETRIC PARALLELS". Clinical anatomy and operative surgery 18, № 4 (2019): 112–17. http://dx.doi.org/10.24061/1727-0847.18.4.2019.18.

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Scientific literature covers separate data concerning development of the internal female reproductive organs and their age-related and individual anatomical peculiarities during the fetal and early neonatal period of human ontogenesis. The objective of the study is to find chronological succession of development and formation of topographic-anatomical interrelations of the uterus during the perinatal period of human ontogenesis. To achieve the purpose the following methods of morphological examination were used: macroscopic, common and thin section, microscopic, vessel injections, making topog

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Hofmeister, B., and U. R. Fischer. "Abnormal multiple pregnancy with septuplets in a cow." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 41, no. 04 (2013): 253–56. http://dx.doi.org/10.1055/s-0038-1623180.

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SummaryA 5-year-old Brown Swiss cow being 8 months pregnant became recumbent and died. Postmortem examination revealed a multiple pregnancy with six normally developed fetuses and an amorphous globosus. The cow’s internal organs were displaced and compressed the lungs. Fatty liver caused by metabolic disturbances was diagnosed. A multiple pregnancy with more than two fetuses is very rare in cattle. It could be induced by treatment with exogenous hormones, but it could also be the result of genetic selection.

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Morrison, J. L., K. J. Botting, J. L. Dyer, S. J. Williams, K. L. Thornburg, and I. C. McMillen. "Restriction of placental function alters heart development in the sheep fetus." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 293, no. 1 (2007): R306—R313. http://dx.doi.org/10.1152/ajpregu.00798.2006.

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Placental insufficiency, resulting in restriction of fetal substrate supply, is a major cause of intrauterine growth restriction (IUGR) and increased neonatal morbidity. Fetal adaptations to placental restriction maintain the growth of key organs, including the heart, but the impact of these adaptations on individual cardiomyocytes is unknown. Placental and hence fetal growth restriction was induced in fetal sheep by removing the majority of caruncles in the ewe before mating (placental restriction, PR). Vascular surgery was performed on 13 control and 11 PR fetuses at 110–125 days of gestatio

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