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Dissertations / Theses on the topic 'FGF2 Signaling'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

BENNETT, MICHAEL R. "PERTURBATIONS IN OLIGODENDROCYTE PROGENITOR GROWTH AND DIFFERENTIATION: NEUROFIBROMIN AND FGF2 SIGNALING." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100015367.

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2

Bennett, Michael R. "Perturbations in oligodendrocyte progenitor growth and differentiation neurofibromin and FGF2 signaling /." Cincinnati, Ohio : University of Cincinnati, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1100015367.

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3

Dolivo, David. "Fibroblast activation and pro-fibrotic phenotypes: modulation by FGF2 and MAPK signaling." Digital WPI, 2018. https://digitalcommons.wpi.edu/etd-dissertations/477.

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Fibrotic diseases are a leading cause of morbidity and mortality in the developed world. Despite this, the lack of therapies for fibrotic pathological disease states is severe. A large part of the reason for this lack of viable therapies is due to an incomplete understanding of the early processes driving tissue fibrosis, as well as the dismal results of pharmacologic monotherapies at the clinical trial stage in humans thus far. Therefore, better understanding of the upstream mechanisms driving tissue fibrosis is imperative. One of the common mechanisms underlying all fibroses is the presence

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4

Payne, Laura Beth. "Differential Impact of VEGF and FGF2 Signaling Mechanisms on Flt1 Pre-mRNA Splicing." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/81133.

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The human proteome is exponentially derived from a limited number of genes via alternative splicing, where one gene gives rise to multiple proteins. Alternatively spliced gene products, although crucial for normal physiology, are also linked to an increasing number of pathologies. Consequently, a growing focus is currently being placed on elucidating the extrinsic cues and ensuing signaling mechanisms which direct changes in gene splicing to yield functionally distinct proteins. Of note is the dysregulation of the vascular endothelial growth factor (VEGF) receptor, Flt1 and its soluble splice

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5

Olson, Nels Eric. "FGF2 is weakly mitogenic for intimal smooth muscle cells : role of FGF receptor expression, cytoplasmic signaling and cell cycle regulation /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/6335.

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6

Kinkl, Norbert. "Mechanisms of action of fibroblast growth factor 2 (FGF2) in rat retinal cells : photoreceptor survival and intracellular signaling." Université Louis Pasteur (Strasbourg) (1971-2008), 2001. http://www.theses.fr/2001STR13166.

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La dégénérescence des photorécepteurs est à l'origine de nombreuses pathologies rétiniennes aboutissant à une malvoyance voire à la cécité. Les facteurs neurotrophiques représentent une approche thérapeutique potentielle. Au cours de cette thèse nous nous sommes intéressés aux mécanismes d'actions in vitro d'un facteur neurotrophique exprimé dans la rétine, le FGF2. Afin d'étudier les effets directs du FGF2 sur la survie des photorécepteurs, nous avons mis au point un nouveau modèle de culture pure en photorécepteurs à partir de rétine jeune de rat. La pureté en photorécepteurs des cultures es

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7

Kolanczyk, Maria Elzbieta. "Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1242722157657-12154.

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Fibroblast growth factor (Fgf) signaling plays multiple inductive roles during development of vertebrates (Itoh 2007). Some Fgfs, such as Fgf8, are locally secreted and signal over a long range to provide positional information in the target tissue (Scholpp and Brand 2004). Fgf ligands signal in a receptor-dependent manner via tyrosine kinase receptors, four of which have been so far identified. Fgf8 signaling was shown to depend both on receptor activation as well as endocytosis. The specificity of Fgf ligands and receptors as well as the function of receptors in the control of the Fgf signal

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8

Goetz, Rebekka [Verfasser], and Annette [Akademischer Betreuer] Neubüser. "FGF signaling in mouse olfactory placode development = Der FGF Signalweg und seine Rolle während der Entwicklung des olfaktorischen Systems der Maus." Freiburg : Universität, 2012. http://d-nb.info/1123472912/34.

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9

Bobbs, Alexander Sebastian. "FGF Signaling During Gastrulation and Cardiogenesis." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/265335.

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An early event in animal development is the formation of the three primary germ layers that define the body plan. During gastrulation, cells migrate through the primitive streak of the embryo and undergo changes in morphology and gene expression, thus creating the mesodermal and endodermal cell layers. Gastrulation requires expression of Fibroblast Growth Factor (FGF), Wnt, and Platelet-Derived Growth Factor (PDGF). Embryos treated with FGF inhibitors fail to gastrulate, as cell migration is completely halted. During gastrulation, 44 microRNAs are expressed in the primitive streak of G. gallus

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10

Stewart, Courtney Elizabeth. "Astrocyte Development and Function is FGF8 Signaling Dependent." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1556290142104336.

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11

Keightley, Margaret Claire. "Autocrine and paracrine regulation of endothelial cell function by F-Prostanoid receptor signalling." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4809.

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Endometrial adenocarcinoma, originating from the glandular epithelial cells of the uterine endometrial lining, is one of the most prevalent cancers amongst women in the Western world. The prostaglandin F2α (PGF2α) receptor (FP) is upregulated in endometrial adenocarcinoma. A previous microarray analysis of endometrial adenocarcinoma cells (Ishikawa) identified numerous targets of PGF2α-FP signalling including angiogenic factors, VEGF-A, FGF-2, CXCL1 and CXCL8 and antiangiogenic factors ADAMTS1. The regulation of VEGF-A, FGF-2, CXCL1 and CXCL8 was confirmed by previous studies using an in vitro

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12

Chan, Kui-ming. "MT1-MMP in craniofacial development and FGF signaling." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/b40203645.

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13

Chan, Kui-ming, and 陳居明. "MT1-MMP in craniofacial development and FGF signaling." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B40203645.

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14

Hartge, Abbie A. "The role of FGF signaling in retinal development." View the abstract Download the full-text PDF version, 2008. http://etd.utmem.edu/ABSTRACTS/2008-053-Hartge-index.htm.

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Thesis (M.S.)--University of Tennessee Health Science Center, 2008.<br>Title from title page screen (viewed on January 29, 2009). Research advisor: Dr. Michael A. Dyer, Ph.D. Document formatted into pages (vi, 47 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 41-44).

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15

Smith, Terence Gordon. "Fgf signalling in somite patterning and organogenesis." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423390.

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16

Zhang, S. (Shaobing). "Kidney development: roles of Sprouty, Wnt2b and type XVIII collagen in the ureteric bud morphogenesis." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514269918.

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Abstract The mammalian metanephric kidney develops through ureteric bud branching morphogenesis and tubule formation and involves secreted inductive signals and possibly their antagonists to regulate the process. Sprouty (spry) genes encode antagonists of FGFs and the EGF signalling pathways. To get an insight to potential developmental roles of the spry genes, the expression of spry1, 2 and 4 was analyzed in developing kidney. Spry1 is expressed in the ureteric bud, and spry2 and 4 in the ureteric bud, the kidney mesenchyme and the nephrons deriving from it suggesting developmental roles for

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17

Corella, Kristina Marie. "The Development of the Corpus Callosum is Dependent Upon FGF8 Signaling." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1404993914.

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18

Branney, Peter A. "Targets of FGF signalling during early Xenopus development." Thesis, University of York, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441094.

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19

Aurikko, Jukka Petteri. "Structural studies of FGF and NGF signalling systems." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613132.

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20

Low, Keri Lynn. "FGF4 and Wnt5a/PCP signaling promote limb outgrowth by polarizing limb mesenchyme /." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1612.pdf.

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21

Voelkel, Jacob Eugene. "A Model for Sensory Neuron Development by FGF and Notch: A Multifactorial Approach." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4122.

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The ophthalmic trigeminal placode (opV) exclusively gives rise to sensory neurons. A number of signaling pathways including Wnt, PDGF, FGF, and Notch are all involved in the progression of an undifferentiated cell in the opV placode to a proneural cell in the condensing opV ganglion. However, the regulatory relationships between these signal transduction pathways are still unknown. To determine if FGF activation acts to modulate Notch signaling in the sensory neurogenesis pathway, a novel multifactorial approach was employed: FGF signaling was inhibited in individual cells and globally with si

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22

Bogardi, Jean-Philippe Achmed Alfred ToÌˆhuÌˆtoÌˆm. "BMP 4 and FGF 8 signalling in maxillary development." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249250.

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23

Khosravi, Mardakheh Faraz. "Regulation of FGF Receptor signalling by SPROUTY and SPRED." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/730/.

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Signalling from Fibroblast Growth Factor Receptors (FGFRs) is under tight control by a wide variety of extrinsic and intrinsic regulatory mechanisms, many of which remain poorly defined. Sproutys and their related Spred proteins constitute two such families of signalling regulators with multiple developmental roles as well as potential tumour suppressive functions. However, the molecular mechanisms of these proteins have remained unclear and subject to many unresolved controversies. Using a mass spectrometry approach, several novel interacting partners of Sprouty with roles in endocytosis are

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24

Jastrebova, Nadja. "Role of Heparan Sulfate Structure in FGF-Receptor Interactions and Signaling." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8717.

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<p>Heparan sulfate (HS) belongs to the glycosaminoglycan family of polysaccharides and is found attached to protein cores on cell surfaces and in the extracellular matrix. The HS backbone consists of alternating hexuronic acid and glucosamine units and undergoes a number of modification reactions creating HS chains with alternating highly and low modified domains, where high degree of modification correlates with high negative charge. Fibroblast growth factors (FGFs) and their receptors (FRs) both bind to HS, which affect formation of the FGF–FR complexes on the cell surfaces. Activated FRs ca

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25

Wu, Yingjie. "The Significance of FRS2 Phosphorylation in EGF- and FGF-Induced Signaling." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-12287.

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26

Regan, Jennifer Claire. "FGF-signalling and the development of CNS asymmetry in zebrafish." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1446056/.

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Neuroanatomical and functional asymmetries are a widespread, probably universal, feature of the vertebrate nervous system. Although brain asymmetry is a fundamental characteristic of the CNS, how it is established is not known. The epithalamus is a subdivision of the diencephalic region of the forebrain and structural asymmetries in this region are widespread among vertebrates. The epithalamus of the zebrafish shows differences between the left and right sides in terms of neuronal organization, connectivity and gene expression and has become a focus for the study of establishment and elaborati

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27

Aragón, Manresa Ferran. "The role of vHnf1 and Fgf Signaling in the caudal Hindbrain Patterning." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7147.

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Durant els primers estadis del desenvolupament embrionari dels metazous els teixits embrionaris son progressivament regionalitzats fins que adquireixen destins específics. En els vertebrats, el tub neural, que és el primordi del sistema nerviós central, es tempranament regionalitzat en el seu eix antero-posterior i queda dividit en les tres vesícules cerebrals i la medul·la espinal. La vesícula cerebral més posterior rep el nom de rombencèfal. En el rombencèfal un següent estadi de regionalització condueix cap a una organització en una serie de segments anomenats rombomers. Aquesta organitzaci

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28

Wei, Lu. "Interaction entre les voies de signalisation FGF et Notch lors de la migration de la parapineale dans le cerveau asymétrique du poisson zèbre." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30197/document.

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Lors du développement de l'asymétrie gauche droite dans le cerveau du poisson zèbre, un petit groupe de cellules, le parapinéale, migre collectivement depuis la ligne médiane vers la partie gauche de l'épithalamus. Cette migration est défectueuse dans des mutants pour le gène fgf8, indiquant que le facteur Fgf8 (Fibroblast Growth Factor 8), sécrété de part et d'autre de la ligne médiane, est requis pour la migration. Cependant, l'orientation gauche de la migration dépend de l'activation, plus précocement dans l'épithalamus gauche, de la voie de signalisation Nodal/TGFb (Transforming Growth Fac

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29

Yan, Dong. "Functions of Glypicans in Cell Signaling during Drosophila Development." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1239036587.

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30

De, Sousa Coelho Ana Luisa. "Metabolic signaling under nutrient deprivation." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/83459.

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1- ROLE OF SIRT1 IN THE REGULATION OF FATTY ACID OXIDATION AND KETOGENESIS UNDER DIFFERENT NUTRIONAL CHANGES. The homolog of the yeast silencing information regulator2 (SIRT1) has been implicated in several aspects of food limitation and caloric restriction in mammals. We have observed that there were no important changes, between wild type (WT) and SIRT1 liver-specific knockout (LKO) mice subjected to either CR or high fat diet (HFD), in the mRNA expression of Cpt1a, Cpt2 and Hmgcs2. SIRT1 had been shown to control hepatic glyconeogenic/glycolytic pathways in response to nutrients (Rodg

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31

Lee, K. M. A. "FGF and TGFbeta signalling in an in-vitro model of craniosynostosis." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18003/.

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Fibroblast Growth Factor (FGF) and Transforming Growth Factor beta (TGFbeta) are key regulators of bone development. Constitutively activating mutations of FGF Receptors (FGFR) 1-3 result in craniosynostosis, premature fusion of cranial sutures. The aim of this thesis was to determine how FGF signalling is impaired in osteoblasts with the mutation FGFR2-C278F, known to induce craniosnostosis and investigate possible interactions with TGFbeta signalling. To this purpose MC3T3-E1 osteoblasts (derived from newborn mouse calvaria) that had been stably transfected with human FGFR2 (wild type FGFR2-

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32

Maroon, Habib Anton. "The role of FGF signalling in otic placode induction and specification." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423317.

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33

Auciello, Giulio. "Analysis of FGF receptor signalling and trafficking by live-cell imaging." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4650/.

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Fibroblast growth factor receptors (FGFRs) regulate fundamental cellular processes, including proliferation, differentiation and angiogenesis and have emerged as growth factor receptors central to oncogenesis. This study developed a live-cell assay system for studying FGFR endocytosis and trafficking by employing both confocal and total internal reflection fluorescence (TIRF) microscopy in cells expressing a previously characterised GFP-tagged FGFR2 construct. Data from this work have demonstrated that endocytosis of activated FGFR occurs through clathrin-mediated endocytosis. Interestingly, F

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34

Maurer, Jennifer M. "Regulation of the FGF/ERK Signaling Pathway: Roles in Zebrafish Gametogenesis and Embryogenesis." eScholarship@UMMS, 2017. http://escholarship.umassmed.edu/gsbs_diss/926.

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Signaling cascades, such as the extracellular signal-regulated kinase (ERK) pathway, play vital roles in early vertebrate development. Signals through these pathways are initiated by a growth factor or hormone, are transduced through a kinase cascade, and result in the expression of specific downstream genes that promote cellular proliferation, growth, or differentiation. Tight regulation of these signals is provided by positive or negative modulators at varying levels in the pathway, and is required for proper development and function. Two members of the dual-specificity phosphatase (Dusp) fa

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35

Ono, Kazuya. "FGFR1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation." Kyoto University, 2014. http://hdl.handle.net/2433/188680.

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36

Ryan, Paula J. "Characterization of the FGF receptor signaling complex in Xenopus laevis during early embryonic development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0020/MQ54958.pdf.

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37

Ryan, Paula. "Characterization of the FGF receptor signaling complex in Xenopus laevis during early embryonic development /." St. John's, NF ; [s.n.], 1999.

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38

Groves, Julie Anne. "Fgf8 signalling is required for formation of early fast muscle in the zebrafish, Danio rerio." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432042.

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39

Holmqvist, Kristina. "The Role of Shb in Angiogenesis, FGF and VEGF Signalling in Endothelial Cells." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3943.

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<p>Angiogenesis is defined as the formation of new capillary blood vessels from pre-existing ones. This process involves several steps including: migration, proliferation and differentiation of endothelial cells into blood vessels. Angiogenesis is initiated by binding of specific growth factors, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), to their cell surface receptors. Shb is a ubiquitously expressed adaptor protein with the ability to bind several tyrosine kinase receptors. My aim has been to identify the role of Shb in FGF- and VEGF-signalling in e

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40

Balasooriya, Gayan Indhu. "The role of Fgf receptor signalling in adult mouse tracheal stem cell regulation." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709163.

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41

Romero-Guevara, Ricardo. "The role of FGF signalling during otic differentiation in human pluripotent stem cells." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/5222/.

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42

Warrander, Fiona. "The role of lin28, an FGF signalling target, in development and miRNA regulation." Thesis, University of York, 2012. http://etheses.whiterose.ac.uk/3389/.

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The related genes lin28a and lin28b code for conserved RNA-binding proteins, which contain two key RNA-binding motifs that determine their functions. Previously, our laboratory identified lin28a as a putative downstream target of FGF signalling in the early Xenopus embryo. This was found to occur at gastrulation stage, during which key signalling pathways such as the FGF pathway are active in specifying germ layer development. lin28 is a heterochronic gene in C. elegans and controls the timing of developmental events. In vertebrates, the lin28a gene shows pluripotent-specific expression, and h

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43

Zhao, Haotian. "Exploring the role of fibroblast growth factor (FGF) signaling in mouse lens fiber differentiation through tissue-specific disruption of FGF receptor gene family." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1072722841.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xii, 203 p.; also includes graphics (some col.) Includes bibliographical references (p. 179-203). Available online via OhioLINK's ETD Center

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Rengarajan, Charanya [Verfasser], and S. [Akademischer Betreuer] Scholpp. "Hsc70 mediated endocytosis regulates Fgf signaling in early zebrafish development / Charanya Rengarajan. Betreuer: S. Scholpp." Karlsruhe : KIT-Bibliothek, 2013. http://d-nb.info/1049236947/34.

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Qiu, Qingchao. "TGF-β, WNT, AND FGF SIGNALING PATHWAYS DURING AXOLOTL TAIL REGENERATION AND FORELIMB BUD DEVELOPMENT". UKnowledge, 2019. https://uknowledge.uky.edu/neurobio_etds/24.

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Tgf-β, Wnt, and Fgf signaling pathways are required for many developmental processes. Here, I investigated the requirement of these signaling pathways during tail regeneration and limb development in the Mexican axolotl (Ambystoma mexicanum). Using small chemical inhibitors during tail regeneration, I found that the Tgf-β signaling pathway was required from 0-24 and 48-72 hours post tail amputation (hpa), the Wnt signaling pathway was required from 0-120 hpa, and the Fgf signaling pathway was required from 0-12hpa. Tgf-β1 was upregulated after amputation and thus may mediate Tgf-β signaling pa

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46

METZGER, DAVID EDWARD. "THE ROLE OF THE ETS TRANSCRIPTION FACTOR Elf5 IN LUNG DEVELOPMENT." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1197664589.

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47

Zhu, Min-yan. "A genetic screen for genes involved in the FGF signalling pathway in Drosophila melanogaster." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969518048.

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48

Willis, Susan. "Investigation of FGF signalling inhibitors in prostate cancer and the development of novel therapies." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516328.

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49

Chan, Wai Kit. "Role of differential heparan sulphate sulphation in Fgf/Erk signalling during mouse telencephalic development." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25718.

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Heparan sulphate proteoglycans (HSPGs) are cell surface/secreted molecules expressed by all cells. HSPGs consist of carbohydrate side-chains attached to a core protein and are involved in regulating key signalling pathways in the developing mammalian brain via sugar-protein interactions. It has been hypothesized, in the ‘heparan sulphate (HS) code hypothesis’, that the specificity for the interaction between the HSPGs and particular signalling pathways is encoded by its HS side-chain. HS has an enormous variety of structures due to postsynthetic modification. Hs2st and Hs6st1 are enzymes invol

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Jackson, Abigail. "The regulation of pharyngeal pouch morphogenesis by TBX1 and FGF signalling in the endoderm." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/the-regulation-of-pharyngeal-pouch-morphogenesis-by-tbx1-and-fgf-signalling-in-the-endoderm(fbd54a00-52cc-4fcc-ae8e-70662a660a4c).html.

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The pharyngeal apparatus is comprised of a series of pharyngeal arches that are defined by the evagination of endodermal pouches toward the ectoderm. Whilst the transcription factor T‐box 1 (Tbx1) and the Fibroblast growth factor 8 (Fgf8) are both required for caudal pouch formation, a role for these factors in the endoderm during pouch morphogenesis has not been confirmed. The observation that Fgf8 expression is lost in Tbx1 homozygous null mutant embryos has lead to the hypothesis that FGF8 functions directly downstream of TBX1 during pouch formation. To test this hypothesis the Sox17‐2A‐ic

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