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Journal articles on the topic 'Fibonacci levels'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Baranauskas, Simas. "Elliott Wave and Fibonacci Level Mutual Relationship and Applying in a Stock Market." Business: Theory and Practice 12, no. (4) (2011): 390–97. https://doi.org/10.3846/btp.2011.40.

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The main purpose of this article is to evaluate at what Fibonacci level mostly the price changes, which coincides with the Elliott wave peaks. The paper analyzes the Elliott wave and Fibonacci level mutual relationship theories which could affect the investor's decisions. After research, it was estimated that on the Lithuanian and U.S. stock markets at 61.8% Fibonacci level shares direction usually changed. Other important Fibonacci levels are estimated.

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Veerendra, Anchan, Shah Vansh, Desai Vatsal, and Shah Rushabh. "Applicability of Fibonacci Series on Low Beta Stocks of Nifty-50." INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS 07, no. 11 (2024): 5107–12. https://doi.org/10.5281/zenodo.14129604.

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This study explores the relationship between stock volatility, measured by beta & price movement patterns using the Fibonacci series in the context of low beta stocks. Low beta stocks, typically more stable than high beta ones, were analyzed using Fibonacci retracement & extension levels to identify key support & resistance points. Historical price data from Nifty 50 low beta were examined under various market conditions including bullish, bearish & stable. The findings from our research indicate that the low beta stocks adhere to Fibonacci levels, hence it offers reliable long

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Gurrib, Ikhlaas. "Technical Analysis, Energy Cryptos and Energy Equity Markets." International Journal of Energy Economics and Policy 12, no. 2 (2022): 249–67. http://dx.doi.org/10.32479/ijeep.11015.

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The aim of this study is to investigate if Fibonacci retracements levels, as a popular technical analysis indicator, can serve to predict stock prices of leading US energy companies and energy crypto currencies. The methodology centers on the application of Fibonacci retracements as a trading system. Daily stock prices from the top ten constituents of the S&P Composite 1500 Energy Index are sourced, spanning from 21st November 2017 to 17th January 2020. The performance of the Fibonacci's tool is captured using the Sharpe measure. The model is also benchmarked against the naÃ¯ve buy-and-hol

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Priambodo, Bagus, Ruci Meiyanti, Samidi Samidi, Gushelmi Gushelmi, Rabiah Abdul Kadir, and Azlina Ahmad. "Integrating Fibonacci Retracement To Improve Accuracy of Time Series Prediction of Gold Prices." Journal of Applied Engineering and Technological Science (JAETS) 6, no. 2 (2025): 1268–79. https://doi.org/10.37385/jaets.v6i2.6073.

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The prediction of gold prices is crucial for investors and policymakers due to its significant impact on global financial markets. Machine learning and deep learning have been used for predicting gold prices on time series data. This study employs MLR, SVM and CNN LSTM with Fibonacci retracement levels to forecast gold prices based on time series data. The experiment results demonstrate that combining Fibonacci retracement with model prediction significantly enhances predictive performance compared to prediction without Fibonacci. The use of Fibonacci levels has resulted in a higher R² score a

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Saputri, Ananda, Ifayani Haanurat, and Asri Jaya. "Optimization of Stock Investment Strategy with The Fibonacci Retracement Method to Determine Take Profit and Stop Loss." Eduvest - Journal of Universal Studies 5, no. 1 (2025): 574–90. https://doi.org/10.59188/eduvest.v5i1.50292.

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This research aims to assess the effectiveness of Fibonacci retracement in establishing take profit and stop loss levels for stocks within the LQ45 Index. The study utilizes a quantitative approach with a descriptive method, analyzing daily stock price data from January 2021 to December 30, 2021, through the Fibonacci retracement indicator. The research sample comprises 10 companies listed in the LQ45 Index, selected based on specific criteria. The results demonstrate that Fibonacci retracement is effective in pinpointing significant levels for determining take profit and stop loss, achieving

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Gani, Ahmad, Sigit Wibawa, and Fadli Ilyas. "PENERAPAN POLA FIBONACCI UNTUK PENGATURAN QOS (QUALITY OF SERVICE) JARINGAN." INTI Nusa Mandiri 19, no. 2 (2025): 267–77. https://doi.org/10.33480/inti.v19i2.6359.

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In managing network quality of service (QoS), this research uses the Fibonacci pattern to optimize delay control and bandwidth allocation. QoS is very important in contemporary network management, especially considering the increasing demand for stable and effective data services. This study prioritizes data based on traffic levels using a Fibonacci algorithm simulation. Each priority is assigned a value corresponding to the Fibonacci sequence, which allows for resource allocation that is more in line with network load.The simulation was conducted under normal and overload conditions. The rese

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Oikonomou, Panagiotis, George K. Kranas, Maria Sapounaki, et al. "Square-Based Division Scheme for Image Encryption Using Generalized Fibonacci Matrices." Mathematics 13, no. 11 (2025): 1781. https://doi.org/10.3390/math13111781.

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This paper proposes a novel image encryption and decryption scheme, called Square Block Division-Fibonacci (SBD-Fibonacci), which dynamically partitions any input image into optimally sized square blocks to enable efficient encryption without resizing or distortion. The proposed encryption scheme can dynamically adapt to the image dimensions and ensure compatibility with images of varying and high resolutions, while it serves as a yardstick for any symmetric-key image encryption algorithm. An optimization model, combined with the Lagrange Four-Square theorem, minimizes trivial block sizes, str

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Toet, D., M. Potemski, Y. Y. Wang, J. C. Maan, L. Tapfer, and K. Ploog. "Experimental observation of Landau levels in nonperiodic (Fibonacci) superlattices." Physical Review Letters 66, no. 16 (1991): 2128–31. http://dx.doi.org/10.1103/physrevlett.66.2128.

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9

Dion, Gloria S. "Fibonacci Meets the TI-82." Mathematics Teacher 88, no. 2 (1995): 101–5. http://dx.doi.org/10.5951/mt.88.2.0101.

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Graphing calculators have had a significant impact at many levels in high school and college mathematics in the past few years. We have had to reexamine what we teach and how we teach. Topics that were once the exclusive province of calculus, such as max-min problems, are currently studied by algebra students working with graphing calculators. We have added to our syllabi new techniques, such as zoom and trace; new concepts, such as complete graph and friendly viewing window; and new mathematics, such as chaos and fractals. Graphing calculators have helped us enhance, enrich, and enliven our c

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I Kadek Dwik Darmawan and Henny Rahyuda. "Technical Analysis of Stock Price Movements Using Fibonacci Retracement and Moving Average Convergence Divergence Approaches." International Journal of Economics, Management and Accounting 1, no. 4 (2024): 430–49. http://dx.doi.org/10.61132/ijema.v1i4.293.

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This study aims to evaluate the accuracy of the Fibonacci Retracement and Moving Average Convergence Divergence (MACD) technical indicators in analyzing the movement of banking stock prices listed on the LQ45 index in the 2020 period. Based on data from PT Kustodian Sentral Efek Indonesia (KSEI) in 2023, there was a significant increase in the number of investors in the Indonesian stock market by 103.6 percent in 2020. This study uses a quantitative descriptive approach with a census method for sampling, which resulted in 5 banking companies as samples: BBCA, BBNI, BBRI, BBTN, and BMRI. Data a

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Meiliza, Dewi Ratiwi, and Bayu Hari Prasojo. "Pendekatan Rasio Fibonacci Dan Fuzzy Logic Sebagai Analisis Teknikal Dalam Menentukan Keputusan Investasi Saham." JBMP (Jurnal Bisnis, Manajemen dan Perbankan) 5, no. 2 (2019): 40. http://dx.doi.org/10.21070/jbmp.v5i2.2730.

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Along with the rapid development of the times there was a shift in the investment perspec- tive for the community. At present investment has become a necessity for most people. One type of investment that has high profit potential and a not too long period of time is stock. Shares are a sign of ownership or ownership of a person or entity in a company. Stock prices continue to experience movement following supply and demand. Efforts to anticipate the movement of stock prices every day in the capital market is by using stock price analysis. One form of approach used to analyze stock prices is b

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Minati, Mishra. "IMAGE ENCRYPTION USING FIBONACCI-LUCAS TRANSFORMATION." International Journal on Cryptography and Information Security (IJCIS) 2, no. 3 (2020): 131–41. https://doi.org/10.5281/zenodo.3775563.

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Secret communication techniques are of great demand since last 3000 years due to the need of information security and confidentiality at various levels of communication such as while communicating confidential personal data , patients’ medical data, countries’ defence and intelligence information, data related to examinations etc. With advancements in image processing research, Image encryption and Steganographic techniques have gained popularity over other forms of hidden communication techniques during the last few decades and a number of image encryption models are suggested by

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V, Ravindran. "A STUDY ON THE ROLE OF TECHNICAL ANALYSIS IN PREDICTING SHORT-TERM PRICE MOVEMENTS IN THE STOCK MARKET." International Scientific Journal of Engineering and Management 03, no. 05 (2024): 1–9. http://dx.doi.org/10.55041/isjem01946.

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This research explores the efficacy of technical analysis in predicting short-term stock market movements. The study investigates various technical analysis tools, including support and resistance levels, Fibonacci retracement, and swing highs and lows, applied to a selection of stocks from Bank Nifty. The primary objective is to evaluate the effectiveness of these tools in forecasting price trends and providing actionable trading insights. Data was analyzed over a five-year period, utilizing a blend of qualitative and quantitative research methods. Findings indicate that while technical analy

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Andrica, Dorin, and Ovidiu Bagdasar. "On Generalized Lucas Pseudoprimality of Level k." Mathematics 9, no. 8 (2021): 838. http://dx.doi.org/10.3390/math9080838.

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We investigate the Fibonacci pseudoprimes of level k, and we disprove a statement concerning the relationship between the sets of different levels, and also discuss a counterpart of this result for the Lucas pseudoprimes of level k. We then use some recent arithmetic properties of the generalized Lucas, and generalized Pell–Lucas sequences, to define some new types of pseudoprimes of levels k+ and k− and parameter a. For these novel pseudoprime sequences we investigate some basic properties and calculate numerous associated integer sequences which we have added to the Online Encyclopedia of In

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15

Lau, Derick, Minh Huynh, and Jewel Johl. "A Population-Based Clinical Trial of Irinotecan and Carboplatin." Journal of Oncology 2009 (2009): 1–5. http://dx.doi.org/10.1155/2009/458528.

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Purpose. Phase I trials of anticancer drugs are commonly conducted using the method of modified Fibonacci. We have developed a population-based design for phase I trials of combining anticancer drugs such as irinotecan and carboplatin.Patients and Methods. Intrapatient dose escalation of irinotecan and carboplatin was performed according to a predetermined schema to reach individual dose-limiting toxicity (DLT) in 50 patients with solid tumors refractory to previous chemotherapy. The individual toxicity-limiting dose levels were analyzed for normal distribution using the method of Ryan-Joiner

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Houede, N., A. Kramar, and X. Paoletti. "Evaluation of statistical designs of phase I/II clinical trials for cancer patients published in 2005." Journal of Clinical Oncology 25, no. 18_suppl (2007): 14077. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14077.

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14077 Background: Phase I trials determine the maximal safe dose that could be used in phase II trials. Designs are based on the assumption that efficacy and toxicity increase with dose. Phase I/II trials determine the safety, dosage levels, and response rate. This review addresses statistical issues of phase I/II studies designs. Methods: We reviewed phase I/II clinical trials for cancer patients published in 2005. The main criteria were: type of treatment, statistical design, endpoints, expected efficacy and toxicity, one- or two-steps designs, dose levels, definition of Dose Limiting Toxici

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Owais Khan, Muhammad Ismail, and Imad Ali. "A Dual-Channel MAC Protocol with Fibonacci Backoff for Enhanced Efficiency in UAV-Based Sensor Networks." Proceedings of the Pakistan Academy of Sciences: A. Physical and Computational Sciences 61, no. 2 (2024): 217–25. http://dx.doi.org/10.53560/ppasa(61-2)847.

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Unmanned aerial vehicles (UAVs) are highly effective in collecting data from challenging environments equipped with Wireless Sensor Networks (WSNs), overcoming retrieval challenges. However, using a single-channel Medium Access Control (MAC) protocol for synchronization can lead to potential data collisions among multiple sensors sharing the same medium and result in high power consumption. In this article, we propose a dual-channel MAC protocol specifically designed for UAV-based data collection from WSNs. The protocol includes features such as varying transmission power levels for UAVs, dedi

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Slanbekova, Asylzat Yermanovna. "CLASSIFICATION OF GDP GROWTH IN KAZAKHSTAN." Bulletin of Toraighyrov University. Physics & Mathematics series, no. 4.2020 (December 29, 2020): 18–25. http://dx.doi.org/10.48081/otui1421.

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This article analyzes the stochastic dynamics of the GDP of the Republic of Kazakhstan using applied problems, economic and mathematical models and using statistics from the World Bank. By structural characteristics, such as: building a trajectory of equilibrium growth, adjusting values by Fibonacci levels, frequency of time intervals, measuring the characteristics of the limiting structure, determining the environment of the economic mass, creating indicators of statistical control data, analyzed the behavioral characteristics and structures of aggregated agents at all stages of growth GDP an

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Andrica, Dorin, Ovidiu Bagdasar, and Michael Th Rassias. "On some links between the generalised Lucas pseudoprimes of level k." Analele Universitatii "Ovidius" Constanta - Seria Matematica 31, no. 1 (2023): 23–46. https://doi.org/10.2478/auom-2023-0002.

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Abstract Pseudoprimes are composite integers sharing behaviours of the prime numbers, often used in practical applications like public-key cryptography. Many pseudoprimality notions known in the literature are defined by recurrent sequences. In this paper we first establish new arithmetic properties of the generalized Lucas and Pell-Lucas sequences. Then we study the recent notion of generalized Pell and Pell-Lucas pseudo-primes of level k, and find inclusions between the sets of pseudoprimes on different levels. In this process we extend several results concerning Fibonacci, Lucas, Pell, and

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20

KARPENKO, VITALII. "GENERALIZED CHARACTERISTICS TYPES OF EXCHANGE TRADING STRATEGIES." HERALD OF KHMELNYTSKYI NATIONAL UNIVERSITY 298, no. 5 Part 1 (2021): 163–69. http://dx.doi.org/10.31891/2307-5740-2021-298-5(1)-27.

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It has been determined that online trading is associated with a significant degree of risk, which can be reduced through a thorough and systematic approach to the choice of exchange trading strategies. The strategy (system) of exchange trading is a personal trading rules that take into account the market situation, knowledge and understanding of the trader of this situation, as well as the trader’s wishes regarding the profitability of trading, taking into account the risks. Trading systems based on technical analysis of stock charts are considered: trend (based on the assumption that the pric

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Alves, Francisco Regis Vieira, and Marlene Dias Alves. "Engenharia Didática para o Teorema de Binet, ou Lamé, ou de De Moivre: Análises Preliminares e a Priori." Revista de Ensino, Educação e Ciências Humanas 19, no. 2 (2018): 103. http://dx.doi.org/10.17921/2447-8733.2018v19n2p103-113.

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Este trabalho apresenta uma proposta de Engenharia Didática - ED que descreve, apenas, as etapas de análises preliminares, análise a priori (e a concepção de duas situações didáticas), que correspondem aos dois primeiros momentos previstos, de modo sistemático, pela ED no campo da Didática da Matemática. O tema envolve uma das formas ou possibilidades de generalização do modelo secular, que prevê a reprodução de casais de coelhos, nomeado por Sequência de Fibonacci – SF. Diante do rico e variado percurso de evolução e sistematização do referido modelo, opta pela generalização de uma fórmula, c

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Gavrilyuk, V. I., S. S. Drapey, B. V. Kaydyk, et al. "Nuclear security risks in Ukraine." Nuclear Physics and Atomic Energy 22, no. 4 (2021): 409–14. http://dx.doi.org/10.15407/jnpae2021.04.409.

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An approach to conducting a qualitative risk assessment in the field of nuclear security was developed. Nuclear security events that might, with a certain probability, take place in Ukraine were identified. Using the method of expert assessment, qualitative assessments of the probabilities of the implementation of identified events and the levels of their consequences were obtained, a matrix of consequences/probabilities, in which Fibonacci numbers were applied when setting the limit values оf risks, was built and a qualitative assessment of risks was carried out. It has been established that

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Rodchenko, Volodymyr, Ganna Rekun, Larysa Fedoryshyna, Ihor Roshchin, and Svitlana Gazarian. "The effectiveness of human capital in the context of the digital transformation of the economy: The case of Ukraine." Journal of Eastern European and Central Asian Research (JEECAR) 8, no. 2 (2021): 202–13. http://dx.doi.org/10.15549/jeecar.v8i2.686.

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The purpose of this article is to empirically assess the qualitative parameters of the effectiveness of human capital for business digitalization in Ukraine. Using a survey of 500 business representatives in Ukraine and the Fibonacci rule, and taking into account the digital business transformation level, the qualitative levels of human capital efficiency have been classified. Also, using the method of principal components, the system of factors of human capital's effectiveness for the intensification of digitalization has been empirically substantiated. An empirical model for assessing the qu

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de Souza, Alencar Franco, Fernando Lessa Tofoli, and Enio Roberto Ribeiro. "Switched Capacitor DC-DC Converters: A Survey on the Main Topologies, Design Characteristics, and Applications." Energies 14, no. 8 (2021): 2231. http://dx.doi.org/10.3390/en14082231.

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This work presents a review of the main topologies of switched capacitors (SCs) used in DC-DC power conversion. Initially, the basic configurations are analyzed, that is, voltage doubler, series-parallel, Dickson, Fibonacci, and ladder. Some aspects regarding the choice of semiconductors and capacitors used in the circuits are addressed, as well their impact on the converter behavior. The operation of the structures in terms of full charge, partial charge, and no charge conditions is investigated. It is worth mentioning that these aspects directly influence the converter design and performance

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Dykan, Valeriia, Oleksandr Pakharenko, Volodymyr Saienko, Andrii Skomorovskyi, and Tetiana Neskuba. "Evaluating the efficiency of the synergistic effect in the business network." Journal of Eastern European and Central Asian Research (JEECAR) 8, no. 1 (2021): 51–61. http://dx.doi.org/10.15549/jeecar.v8i1.646.

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The article aimed to develop a methodology for monitoring the quality level of the synergistic effect of enterprises' economic activity in business network interaction on the example of mechanical engineering in Ukraine. Using the expert assessments of 386 senior and middle managers of 27 mechanical engineering enterprises of the Kharkiv region and the main components' method, the components of qualitative parameters of the synergetic effect of economic activity result from network interaction have been determined. An additive econometric model has been developed to calculate the integrated in

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Moch. Lutfi. "Prediksi Harga Terendah Dan Harga Tertinggi Dengan Menggunakan Metode Anfis Untuk Analisa Teknikal Pada Forex Market." JTIM : Jurnal Teknologi Informasi dan Multimedia 1, no. 3 (2019): 261–68. http://dx.doi.org/10.35746/jtim.v1i3.40.

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Forex Market Is a type of currency trading of the country that handles the world currency market within 24 hours agreed, foreign exchange trading has become an alternative for investors to save more trades in general and traders are required to support good technical analysis of good fundamentals so that able to reap huge profits. Technical analysis is an analysis used to estimate prices will fall at the lower price threshold (support) and the upper price threshold (resistance). Fibonacci Retracement is a method often used for technical analysis of rising prices or rising prices. The data used

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He, Zheng, Yuhang Yang, Libang Hu, and Shuitao Gu. "On the Design of Bionic Hierarchical H-Type Whip Restraints for Nuclear Power Plants." Applied Sciences 15, no. 10 (2025): 5507. https://doi.org/10.3390/app15105507.

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Whip restraints based on thin-walled structures are widely used for protection against high-energy pipe breaks in nuclear power plants due to their excellent impact resistance. Recently, biomimetic and hierarchical structures have emerged as focal points in thin-walled structure research, aimed at enhancing energy absorption capacities. Drawing inspiration from the nautilus shell and Fibonacci spiral, based on the nautilus bionic hierarchical multi-cell (NBHMC) structure, this study introduces a novel Nautilus Bionic Double Hierarchical Multi-Cell (NBDHMC) structure. Finite element analysis wa

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Perez, Jean-claude. "Six Fractal Codes of Biological Life Unifying ATOMS, WAVES and INFORMATION: Perspectives in Exobiology, Cancers Basic Research and Artificial Intelligence Biomimetism Decisions Making." Journal of Medical Informatics and Decision Making 1, no. 4 (2021): 22–79. http://dx.doi.org/10.14302/issn.2641-5526.jmid-21-3900.

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In this theoretical discovery of a law of Life, there is MATHEMATICS (Geometry, Bits and Numbers) that UNIFY 3 universes as complementary as ATOMIC MASS, WAVES, and INFORMATION (DNA, RNA and Amino Acids). The discovery of a simple numerical formula for the projection of all the atomic mass of life-sustaining CONHSP bioatoms leads to the emergence of a set of Nested CODES unifying all the biological, genetic and genomic components by unifying them from bioatoms up to 'to whole genomes. In particular, we demonstrate the existence of a digital meta-code common to the three languages of biology

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Dios-Leyva, M. de, A. Bruno-Alfonso, and Luiz E. Oliveira. "Quasi-periodic structure of Landau magnetic levels and absorption spectra of GaAs - (Ga,Al)As Fibonacci superlattices under in-plane magnetic fields." Journal of Physics: Condensed Matter 9, no. 5 (1997): 1005–17. http://dx.doi.org/10.1088/0953-8984/9/5/007.

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Dragovich, Tomislav, Michael Gordon, David Mendelson, et al. "Phase I Trial of Imexon in Patients With Advanced Malignancy." Journal of Clinical Oncology 25, no. 13 (2007): 1779–84. http://dx.doi.org/10.1200/jco.2006.08.9672.

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Purpose Imexon, a pro-oxidant small molecule, has antitumor activity in preclinical models. The drug induces apoptosis through accumulation of reactive oxygen species. The purpose of this trial was to define the maximum-tolerated dose (MTD), toxicities, pharmacokinetics, and pharmacodynamics of imexon in patients with advanced cancers. Patients and Methods Forty-nine patients with metastatic cancer received intravenous imexon over 30 to 45 minutes for 5 consecutive days (one course) every other week (days 1 through 5 and 15 through 19) monthly. Doses were initially escalated using an accelerat

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Kitagawa, C., H. Saka, T. Adachi, et al. "A dose finding and PK/PD study of weekly amrubicin in patients with refractory or relapsed lung cancer: Central Japan Lung Study Group (CJLSG) 0601 trial." Journal of Clinical Oncology 27, no. 15_suppl (2009): e13517-e13517. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e13517.

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e13517 Background: Amrubicin (AMR) is a potent topoisomerase II inhibitor, and a promising agent for both small cell and non-small cell lung cancer. AMR is usually administered on days 1–3 intravenously. However, it causes severe, occasionally fatal, toxicity of leucopenia and neutropenia. The purpose of this study was to evaluate the safety and tolerability of AMR, to determine the recommended weekly dose, and to conduct a PK/PD study in patients with chemotherapy-refractory or recurrent lung cancer. Methods: Refractory or relapsed non-small cell and small cell lung cancer patients after 1 or

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Nicholas, Martin Kelly, Matthias Holdhoff, Richard A. Peterson, et al. "Phase I study of procaspase activating compound -1 (PAC-1) in combination with temozolomide (TMZ) for the treatment of recurrent malignant glioma." Journal of Clinical Oncology 37, no. 15_suppl (2019): TPS3164. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.tps3164.

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TPS3164 Background: The caspase family of cysteine proteases play key roles in the initiation and execution of apoptosis. The activation of procaspase-3 to caspase-3 is critical in both the intrinsic and extrinsic apoptotic cascades. Procaspase-3 levels are elevated in many cancers, including glioblastoma (GBM). As a result, caspase-3 levels are abnormally low in these tumors; thus they avoid apoptosis. PAC-1 is a small molecule that directly activates procaspase-3 and induces apoptosis of cancer cells. PAC-1 has activity against a wide range of cancer cell lines, and in animal models of cance

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Holdhoff, Matthias, Martin Nicholas, Richard Peterson, et al. "ACTR-63. PHASE I DOSE ESCALATION STUDY OF PROCASPASE ACTIVATING COMPOUND-1 (PAC-1) IN COMBINATION WITH TEMOZOLOMIDE IN PATIENTS WITH RECURRENT ANAPLASTIC ASTROCYTOMA OR GLIOBLASTOMA." Neuro-Oncology 21, Supplement_6 (2019): vi28. http://dx.doi.org/10.1093/neuonc/noz175.105.

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Abstract BACKGROUND Procaspase activating compound -1 (PAC-1) is a small molecule that catalyzes conversion of procaspase-3 to caspase-3 which induces apoptosis in cancer cells. Glioblastoma (GBM) is among the tumors with high concentrations of procaspase-3 and low levels of caspase-3. PAC-1 crosses the blood brain barrier and has been shown to synergize with temozolomide (TMZ) in canine malignant glioma and meningioma that arise spontaneously. METHODS This is a multicenter phase 1 dose-escalation study to assess the maximum tolerated dose (MTD) of PAC-1 administered days 1–21 in combination w

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Lyubushin, N. P., N. E. Babicheva, O. M. Kupryushina, and D. I. Khanin. "Setting up a methodology for evaluating, analyzing and predicting the sustainable development of economic agents amid Grand Challenges." Digest Finance 25, no. 4 (2020): 366–86. http://dx.doi.org/10.24891/df.25.4.366.

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Subject. Mentioned in the Strategy for Scientific and Technological Development of the Russian Federation, Grand Challenges entail difficulties, threats and opportunities for the national development. The complicated nature, scale of problems and threats cannot be addressed, eliminated or resolved by multiplying resources consumed. This aspect should be taken into consideration in evaluating, analyzing and predicting the sustainable development of economic agents operating amid grand challenges. Objectives. We outline a methodology for a set of methods used to evaluate, analyze and predict the

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Ohnuma, T., S. Y. Cho, J. Roboz, et al. "Phase I study of ON 01910.Na by 3-day continuous infusion (CI) in patients (pts) with advanced cancer." Journal of Clinical Oncology 24, no. 18_suppl (2006): 13137. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.13137.

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13137 Background: The benzyl styryl sulfone analog ON 01910.Na is a novel anticancer agent that inhibits mitotic progression and induces apoptosis; it has activity against most human cancer cells in vitro and against a broad spectrum of human xenografts in mice. Cell kill effects are exposure time-dependent in vitro. After 3d exposure 200 nM ON 01910.Na killed > 90% of Daudi lymphoma cells, whereas 40-fold higher drug concentration killed only 50% of cells after 24h exposure. Dogs that received CI of 325 mg/kg/d ×3 failed to reach MTD. Methods: Starting dose 50 mg/m2/d as a 72 hr CI was 1/1

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Suetin, S. N., and T. A. Ilina. "RISK MANAGEMENT IN THE CONTEXT OF A DELAYED CRISIS IN THE RUSSIAN FINANCIAL MARKET." Bulletin of Udmurt University. Series Economics and Law 32, no. 3 (2022): 460–66. http://dx.doi.org/10.35634/2412-9593-2022-32-3-460-466.

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This paper examines the unique tools of asset management during periods of broken cyclicality of crises. In the conditions of a crisis, the practical analysis of financial markets becomes particularly relevant. Effective risk management is a vital prerequisite for companies to operate. At the same time, determining the actual beginning of a crisis and its duration is not an easy task. An error in determining the beginning of a crisis can significantly reduce the effectiveness of the measures taken. This article is devoted to modern methods of risk management in the conditions of crisis in fina

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Berlin, J., J. A. Stewart, B. Storer, et al. "Phase I clinical and pharmacokinetic trial of penclomedine using a novel, two-stage trial design for patients with advanced malignancy." Journal of Clinical Oncology 16, no. 3 (1998): 1142–49. http://dx.doi.org/10.1200/jco.1998.16.3.1142.

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PURPOSE A novel phase I trial design was used to determine the maximum-tolerated dose (MTD) and pharmacokinetics for penclomedine when administered as an intravenous (i.v.) infusion over 1 hour daily for 5 days, repeated every 28 days. This study also tests the feasibility of a novel two-stage design for phase I trials. PATIENTS AND METHODS Twenty-eight patients with advanced malignancy who met standard eligibility criteria were treated with i.v. penclomedine. The initial daily dose was 50 mg/m2. Dose escalations were planned using a modified Fibonacci sequence. One patient was enrolled on eac

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Belanger, Karl, Malcolm Moore, Sharyn D. Baker, et al. "Phase I and Pharmacokinetic Study of Novel l-Nucleoside Analog Troxacitabine Given as a 30-Minute Infusion Every 21 Days." Journal of Clinical Oncology 20, no. 10 (2002): 2567–74. http://dx.doi.org/10.1200/jco.2002.12.047.

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PURPOSE: Troxacitabine (Troxatyl, BCH-4556; BioChem Pharma Inc, Basingstoke, United Kingdom) is a novel synthetic l-nucleoside analog with activity against a broad range of human tumors in preclinical models. Preclinical toxicity suggested a predictable toxicity profile consistent with an agent of this class, with evidence of interspecies differences. We conducted a phase I study of troxacitabine given as a 30-minute infusion once every 21 days. PATIENTS AND METHODS: The starting dose of troxacitabine was 0.025 mg/m2, based on toxicology data from the most sensitive species studied (cynomolgus

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Tohnya, T. M., J. Gulley, P. M. Arlen, et al. "Phase I study of lenalidomide, a novel thalidomide analog, in patients with refractory metastatic cancer." Journal of Clinical Oncology 24, no. 18_suppl (2006): 13038. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.13038.

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13038 Background: Lenalidomide (L), CC5013, is a thalidomide (T) analog that has shown activity in multiple myeloma and myelodysplastic syndromes (MDS); including activity in pts refractory to T. Preclinical studies suggest L has more potent immunomodulatory and antiangiogenic activity than T. We have conducted a phase I clinical trial of L to determine the maximum-tolerated dose (MTD), characterize the side-effects, characterize pharmacokinetics (PK) in pts with solid tumors. Methods: Pts with refractory metastatic cancer were treated on a modified Fibonacci dose-escalation scheme with an ora

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Zhang, Li, Hongyun Zhao, Yuxiang Ma, et al. "A phase I, dose-escalation study of ADG106, a fully human anti-CD137 agonistic antibody, in subjects with advanced solid tumors or relapsed/refractory non-Hodgkin lymphoma." Journal of Clinical Oncology 38, no. 15_suppl (2020): 3105. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3105.

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3105 Background: ADG106 is a fully human agonistic anti-CD137 monoclonal IgG4 antibody, targeting a unique epitope of CD137 with novel mechanism of actions for CD137 agonism, CD137 ligand antagonism and potent cross-linking via FcgRIIb. This phase 1 study was conducted to assess its safety, tolerability, pharmacokinetic (PK) profile, immunogenicity and preliminary efficacy. Methods: Eligible patients with age 18 to 75, ECOG ≤1, measurable lesion received intravenous infusion of ADG106 every 3 weeks for a maximum of 24 months. Accelerated titration was applied in 0.1mg/kg dose level and traditi

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Feinberg, B., R. Kurzrock, M. Talpaz, M. Blick, S. Saks, and J. U. Gutterman. "A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients." Journal of Clinical Oncology 6, no. 8 (1988): 1328–34. http://dx.doi.org/10.1200/jco.1988.6.8.1328.

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We report a phase I clinical investigation of 30-minute and four-hour intravenous (IV) infusions of recombinant tumor necrosis factor (rTNF)-alpha. Thirty-nine patients with disseminated cancer received escalating doses of rTNF-alpha for five consecutive days every 2 weeks for a total duration of 8 weeks. Dose escalations followed a modified Fibonacci scale with a minimum of four patients entered at each dose level: 5, 10, 25, 50, 75, 100, 150, 200, and 250 micrograms/m2/d. Toxicities consisted mainly of constitutional symptoms including fever, chills, headache, and fatigue, increasing in seve

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Punitha, K., Akhlaqur Rahman, A. S. Radhamani, et al. "An Optimization Algorithm for Embedded Raspberry Pi Pico Controllers for Solar Tree Systems." Sustainability 16, no. 9 (2024): 3788. http://dx.doi.org/10.3390/su16093788.

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Solar photovoltaic (PV) systems stand out as a promising solution for generating clean, carbon-free energy. However, traditional solar panel installations often require extensive land resources, which could become scarce as the population grows. To address this challenge, innovative approaches are needed to maximize solar power generation within limited spaces. One promising concept involves the development of biological tree-like structures housing solar panels. These “solar trees” mimic the arrangement of branches and leaves found in natural trees, following patterns akin to phyllotaxy, whic

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O’Connor, Owen A., Robert Z. Orlowski, Melissa Alsina, et al. "Multicenter Phase I Studies To Evaluate the Safety, Tolerability, and Clinical Response to Intensive Dosing with the Proteasome Inhibitor PR-171 in Patients with Relapsed or Refractory Hematological Malignancies." Blood 108, no. 11 (2006): 2430. http://dx.doi.org/10.1182/blood.v108.11.2430.2430.

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Abstract INTRODUCTION: PR-171 is a novel, irreversible proteasome inhibitor under investigation for the treatment of hematological malignancies. In preclinical studies, PR-171 was well tolerated in rats and monkeys when given daily × 5 (QDx5), every two weeks. Proteasome inhibition determined in blood and other tissues one hour after dosing at the maximum tolerated dose (MTD) was >80%. Despite the irreversible mechanism of action, the half-life of recovery of proteasome inhibition in tissues was approximately 24 hours. PR-171 was effective in suppression of tumor growth in xenograft studies

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Dennis, P. A., G. Blumenthal, M. Ballas, et al. "A phase I study of nelfinavir, an FDA approved HIV protease inhibitor, in adults with refractory solid tumors." Journal of Clinical Oncology 27, no. 15_suppl (2009): 2583. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.2583.

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2583 Background: Preclinical studies show that HIV protease inhibitors such as nelfinavir (N) have dose- dependent, pleiotropic anti-cancer activities. However, the maximum tolerated dose (MTD) of N has not been established in humans. Methods: Pts were treated on a modified Fibonacci dose-escalation scheme with a twice daily oral dose of N starting at the FDA approved dose of 1250 mg bid on a 21-day cycle. Patients with refractory solid tumors, ECOG PS < 2, and adequate organ function were eligible. Therapy continued until MTD or disease progression. PBMCs as well as optional tumor biopsies

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Soussain, Carole, Christian Grommes, Samar Issa, et al. "CLRM-15 TRIAL IN PROGRESS: A PHASE 1B/2 STUDY OF GB5121, A NOVEL, HIGHLY SELECTIVE, POTENT, AND CNS-PENETRANT INHIBITOR OF BRUTON’S TYROSINE KINASE (BTKI) FOR RELAPSED/REFRACTORY PRIMARY/SECONDARY CNS LYMPHOMA (R/R PCNSL/SCNSL) AND PRIMARY VITREORETINAL LYMPHOMA (PVRL)." Neuro-Oncology Advances 4, Supplement_1 (2022): i9. http://dx.doi.org/10.1093/noajnl/vdac078.035.

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Abstract BTK plays an important role in B cell receptor and Toll-like receptor signaling pathways, which are constitutively active in primary CNS lymphomas, and hence represents an excellent therapeutic target. Ibrutinib, a first-generation BTKi, was evaluated in phase 1/2 trials for R/R PCNSL, SCNSL, and PVRL, showing limited survival benefit. GB5121 is a novel, orally available, covalent BTKi with superior specificity, CNS penetration, and CNS target occupancy in preclinical testing versus other BTKis including ibrutinib. GB5121 is well-suited for evaluation in CNS lymphoma. This is a phase

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Emons, G., M. Kaufmann, A. R. Günthert, et al. "Phase I study of ZEN-008 (AN-152), a targeted cytotoxic LHRH analog, in female patients with cancers expressing LHRH receptors." Journal of Clinical Oncology 24, no. 18_suppl (2006): 13146. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.13146.

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13146 Background: Human ovarian, endometrial, and breast cancers commonly express receptors for luteinizing hormone releasing hormone (LHRH-R). LHRH-R can be used for targeted chemotherapy with ZEN-008 (AN-152), in which doxorubicin is linked to [D-Lys(6)]-LHRH. Safety pharmacology and toxicity studies in mice, rats and dogs demonstrated a significantly reduced cardiotoxic potential of ZEN-008 compared with doxorubicin, e.g. no QT prolongation, myocarditis or fibrosis in the appropriate models. The Phase I study assessed dose limiting toxicities (DLTs), maximum tolerated dose (MTD), and pharma

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Lee, J., D. Lee, K. Bae, et al. "A phase I and pharmacologic study of belotecan in combination with cisplatin in patients with previously untreated extensive-stage disease small cell lung cancer." Journal of Clinical Oncology 25, no. 18_suppl (2007): 18053. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.18053.

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18053 Background: Belotecan (CKD602) is a novel camptothecin derivative antitumor agent. This phase I study was designed to determine the maximum-tolerated dose (MTD), toxicity profile, and dose-limiting toxicity (DLT) of belotecan in combination with cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer (ED SCLC). Furthermore, pharmacokinetics (PK) and preliminary antitumor activity of belotecan against SCLC were evaluated. Methods: Patients with ED SCLC, age 18–70, ECOG PS 0–2, no prior chemotherapy and adequate organ function were eligible. Cisplatin

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Gutierrez, Martin, S. Gail Eckhardt, W. Larry Gluck, and Ely Benaim. "RX-5902: A phosphorylated p68 targeting agent to treat subjects with advanced solid tumors." Journal of Clinical Oncology 34, no. 4_suppl (2016): TPS778. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.tps778.

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TPS778 Background: Phosphorylated p68 may play a vital role in cell proliferation and tumor/cancer progression. RX-5902 is a novel compound that targets phosphorylated p68 RNA helicase (also known as DDX5), a member of the DEAD box family of RNA helicases. As a single agent, RX-5902 inhibits tumor growth and enhances survival in a variety of xenograft tumor models (e.g., pancreatic, renal, ovarian, melanoma). Methods: This Phase 1, open-label, multicenter study evaluates the efficacy and safety of RX-5902 in subjects with solid tumors. RX-5902 is administered orally 1, 3 or 5 times per week fo

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Liu, Yongheng, Wei Lian, Xi Zhao, et al. "A phase I study of safety and pharmacokinetics of A166, a novel selective inhibitor of human epidermal growth factor receptor-2 in Chinese patients with advanced solid tumors." Journal of Clinical Oncology 38, no. 15_suppl (2020): e13007-e13007. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e13007.

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e13007 Background: Human epidermal growth factor receptor 2 (HER2) is an effective therapeutic target for breast and gastric cancer. A166 is an antibody-drug conjugate composed of a novel cytotoxic drug (monomethyl auristatin F derivative ) site-specifically conjugated to transtuzumab sequence via a stable protease-cleavable valine citrulline linker, which has a DAR (Drug Antibody Ratio) of Better efficacy were observed in preclinical CDX and PDX studies including HER2 low expression and T-DM1 resistant models while toxicity studies demonstrated a good safety profile in cynomolgus monkey. Meth

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Grinchenko, Sergey N., and Yuliya L. Shchapova. "Multidisciplinary Global Archaeology as Branch of Theoretic Knowledge." Space and Time, no. 3/4 (November 29, 2016): 104–13. https://doi.org/10.2226-7271/provr_st3_4-25_26.2016.36.

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The multidisciplinary, global and theoretical archaeology based on mathematics-informatics (numerical) modeling, we suggest designating ‘archaenomy’. Realizing this modeling approach, Yulia L. Shchapova structured concept of ‘archaeological epoch’, designating it as the ‘time cell’, during which the human and his (created by him) artificial environment formed. The chronology of the archaeological epoch with sufficient accuracy is described by Fibonacci’s series, i.e. by ‘golden section’ numerical series. It is equivalent to the statement on

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