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Relevant bibliographies by topics / Fibrin clot properties

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Academic literature on the topic 'Fibrin clot properties'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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Journal articles on the topic "Fibrin clot properties"

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Neergaard-Petersen, Søs, Anne-Mette Hvas, Steen Kristensen, et al. "The influence of type 2 diabetes on fibrin clot properties in patients with coronary artery disease." Thrombosis and Haemostasis 112, no. 12 (2014): 1142–50. http://dx.doi.org/10.1160/th14-05-0468.

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SummaryType 2 diabetes mellitus (T2DM) increases the risk of coronary thrombosis and both conditions are associated with altered fibrin clot properties. However, the influence of T2DM on fibrin clot properties in patients with coronary artery disease (CAD) remains unclear. We aimed to investigate the influence of T2DM on fibrin clot properties in patients with CAD. Fibrin clot structure and fibrinolysis were investigated in 581 CAD patients (148 with T2DM) using turbidimetric assays, confocal and scanning electron microscopy. Clots made from plasma and plasma-purified fibrinogen were studied,

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Undas, Anetta. "Fibrin clot properties and their modulation in thrombotic disorders." Thrombosis and Haemostasis 112, no. 07 (2014): 32–42. http://dx.doi.org/10.1160/th14-01-0032.

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SummaryAccumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clot structure and function in patients with various thromboembolic manifestations, in particular myocardial infarction, ischaemic stroke and venous thromboembolism, based on the publications till December 2013. Moreover, factors will be presented that in vivo unfavourably det

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Martinez, Marissa R., Adam Cuker, Angela M. Mills, et al. "Enhanced lysis and accelerated establishment of viscoelastic properties of fibrin clots are associated with pulmonary embolism." American Journal of Physiology-Lung Cellular and Molecular Physiology 306, no. 5 (2014): L397—L404. http://dx.doi.org/10.1152/ajplung.00265.2013.

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The factors that contribute to pulmonary embolism (PE), a potentially fatal complication of deep vein thrombosis (DVT), remain poorly understood. Whereas fibrin clot structure and functional properties have been implicated in the pathology of venous thromboembolism and the risk for cardiovascular complications, their significance in PE remains uncertain. Therefore, we systematically compared and quantified clot formation and lysis time, plasminogen levels, viscoelastic properties, activated factor XIII cross-linking, and fibrin clot structure in isolated DVT and PE subjects. Clots made from pl

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Piróg, Magdalena, Sławomir Piwowarczyk, and Anetta Undas. "Plasma Fibrin Clot Properties Are Unfavorably Altered in Women following Venous Thromboembolism Associated with Combined Hormonal Contraception." Disease Markers 2019 (November 18, 2019): 1–9. http://dx.doi.org/10.1155/2019/4923535.

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The use of hormonal contraception is associated with an increased risk of venous thromboembolism (VTE). Unfavorably altered fibrin clot phenotype has been reported in patients following unprovoked VTE who are at risk of recurrences. It remains unknown whether fibrin clot characteristics in women with contraception-related VTE differ from those in unprovoked VTE. We studied three age-matched groups of women: (1) after contraception-related VTE, (n=48) (2) after unprovoked VTE (n=48), and (3) controls (n=48). Plasma fibrin clot permeability (Ks), turbidity of clot formation, efficiency of fibrin

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Bridge, Katherine, Helen Philippou, and Robert Ariëns. "Clot properties and cardiovascular disease." Thrombosis and Haemostasis 112, no. 11 (2014): 901–8. http://dx.doi.org/10.1160/th14-02-0184.

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SummaryFibrinogen is cleaved by thrombin to fibrin, which provides the blood clot with its essential structural backbone. As an acute phase protein, the plasma levels of fibrinogen are increased in response to inflammatory conditions. In addition to fibrinogen levels, fibrin clot structure is altered by a number of factors. These include thrombin levels, treatment with common cardiovascular medications, such as aspirin, anticoagulants, statins and fibrates, as well as metabolic disease states such as diabetes mellitus and hyperhomocysteinaemia. In vitro studies of fibrin clot structure can pro

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Gersh, Kathryn, Chandrasekaran Nagaswami, and John Weisel. "Fibrin network structure and clot mechanical properties are altered by incorporation of erythrocytes." Thrombosis and Haemostasis 102, no. 12 (2009): 1169–75. http://dx.doi.org/10.1160/th09-03-0199.

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SummaryAlthough many in vitro fibrin studies are performed with plasma, in vivo clots and thrombi contain erythrocytes, or red blood cells (RBCs).To determine the effects of RBCs on fibrin clot structure and mechanical properties, we compared plasma clots without RBCs to those prepared with low (2 vol%), intermediate (5-10 vol%), or high (≥20 vol%) numbers of RBCs. By confocal microscopy, we found that low RBC concentrations had little effect on clot structure. Intermediate RBC concentrations caused heterogeneity in the fiber network with pockets of densely packed fibers alongside regions with

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Ząbczyk, Michał, Joanna Natorska, and Anetta Undas. "Factor XIII and Fibrin Clot Properties in Acute Venous Thromboembolism." International Journal of Molecular Sciences 22, no. 4 (2021): 1607. http://dx.doi.org/10.3390/ijms22041607.

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Coagulation factor XIII (FXIII) is converted by thrombin into its active form, FXIIIa, which crosslinks fibrin fibers, rendering clots more stable and resistant to degradation. FXIII affects fibrin clot structure and function leading to a more prothrombotic phenotype with denser networks, characterizing patients at risk of venous thromboembolism (VTE). Mechanisms regulating FXIII activation and its impact on fibrin structure in patients with acute VTE encompassing pulmonary embolism (PE) or deep vein thrombosis (DVT) are poorly elucidated. Reduced circulating FXIII levels in acute PE were repo

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Jörneskog, Gun, Anna Ågren, Per-Eric Lins, Håkan Wallén, Aleksandra Antovic, and Sara Tehrani. "Fibrin clot properties and haemostatic function in men and women with type 1 diabetes." Thrombosis and Haemostasis 113, no. 02 (2015): 312–18. http://dx.doi.org/10.1160/th14-05-0404.

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SummaryThe increased risk of vascular complications in type 1 diabetes may in part be explained by changes in haemostatic function. In the present study, we investigated the fibrin clot properties in patients with type 1 diabetes in relation to sex and microvascular complications. The study included 236 patients (107 women) aged between 20–70 years and without any history of cardiovascular disease. Fibrin clot properties, assessed by determination of the permeability coefficient (Ks) and turbidimetric clotting and lysis assays, did not differ between men and women. Compared with men, women had

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Barrett-Bergshoeff, Marrie, A. F. H. Jie, Marco Criscuoli, Dmitri Sakharov, and Dingeman Rijken. "Clot penetration and fibrin binding of amediplase, a chimeric plasminogen activator (K2tu-PA)." Thrombosis and Haemostasis 91, no. 01 (2004): 52–60. http://dx.doi.org/10.1160/th03-07-0435.

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SummaryAmediplase (K2tu-PA) is a hybrid plasminogen activator, consisting of the kringle 2 domain of alteplase and the protease domain of urokinase. The objective of this study was to determine the in vitro clot penetration of amediplase in relation to its fibrin binding and to compare the properties with those of alteplase.The clot lysis activity of amediplase in internal clot lysis models (both purified system and plasma system) was about 10 times less than that of alteplase. The clot lysis activity of amediplase in an external clot lysis model (plasma system) was similar to that of alteplas

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Howes, Joanna-Marie, Victoria R. Richardson, Kerrie A. Smith, et al. "Complement C3 is a novel plasma clot component with anti-fibrinolytic properties." Diabetes and Vascular Disease Research 9, no. 3 (2012): 216–25. http://dx.doi.org/10.1177/1479164111432788.

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Background and method: Increased plasma clot density and prolonged lysis times are associated with cardiovascular disease. In this study, we employed a functional proteomics approach to identify novel clot components which may influence clot phenotypes. Results: Analysis of perfused, solubilised plasma clots identified inflammatory proteins, including complement C3, as novel clot components. Analysis of paired plasma and serum samples confirmed concentration-dependent incorporation of C3 into clots. Surface plasmon resonance indicated high-affinity binding interactions between C3 and fibrinoge

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Dissertations / Theses on the topic "Fibrin clot properties"

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Sumaya, Wael. "Fibrin clot properties and clinical outcomes in patients with acute coronary syndrome : an additional therapeutic target?" Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/20586/.

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Harrand, Robert. "The Viscoelastic Properties of Fibrin Clots Studied Using Magnetic Tweezers." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485168.

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Magnetic tweezers have been designed, constructed, calibrated and 'applied, for the first time, to the study of the mechanical properties of fibrin clots. Three-dimensional control over magnetic particle position was achieved with forces of ''100pN in X,Y and ''IOpN in Z, generated with 4.5JLm Ã‚Â·particles. Software was custom written to control both the operation of the electromagnets and data analysis of the-captured images. The performance of the magnetic tweezers was initially evaluated using model viscous and viscoelastic materials such as polyacrylamide, and was used to demonstrate that

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Meng, Maozhou. "Effects of marine environment exposure on the static and fatigue mechanical properties of carbon fibre-epoxy composite." Thesis, University of Plymouth, 2016. http://hdl.handle.net/10026.1/5341.

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This thesis studies the static and fatigue failure of carbon fibre-epoxy composite for marine use. The primary objective is to investigate the effects of sea water ingress on the static and cyclic performance of laminated composites, by using the combination of experimental, numerical and analytical approaches. Experiments were carried out to collect evidence, including data and images, for further analysis. Samples were made from autoclave-cured carbon fibre-epoxy pre-preg for the static, moisture diffusion and fatigue tests. Three chambers were used in the diffusion test, containing fresh wa

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Kotzé, Christina Magrietha. "Fibrinogen functionality in black South Africans : the PURE study / Christina Magrietha Kotzé." Thesis, 2014. http://hdl.handle.net/10394/15341.

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INTRODUCTION AND AIM Black South Africans are experiencing an increase in the prevalence of cardiovascular disease (CVD). Fibrinogen functionality, including total and gamma prime (y’) fibrinogen concentration, as well as fibrin network structure, play an important role in CVD development and events. Several genetic and environmental factors influence fibrinogen functionality, and in turn, known CVD risk factors associated with total and y’ fibrinogen concentration have also been associated with altered fibrin clot structure. However, the main body of evidence regarding the role of fibrinogen

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Book chapters on the topic "Fibrin clot properties"

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Becker, Richard C., and Frederick A. Spencer. "Historical Perspectives in Hemostasis, Coagulation, and Fibrinolysis: A Foundation for Understanding Thrombotic Disorders and Developing Effective Treatment." In Fibrinolytic and Antithrombotic Therapy. Oxford University Press, 2006. http://dx.doi.org/10.1093/oso/9780195155648.003.0005.

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Hemostasis, the prompt cessation of bleeding at a site of vascular injury, is among the most fundamental physiologic and teleologically vital defense mechanisms in nature. Without a functionally intact hemostatic mechanism, death could ensue rapidly even after minor traumas associated with everyday life. In mammalian blood coagulation, regulated by a complex network of integrated biochemical events, five protease factors (f ) (fIIa [thrombin], fVIIa, fIXa, fXa, and protein C) interact with five cofactors (tissue factor, f VIIIa, fVa, thrombomodulin, and protein S) to regulate the generation of fibrin (Davidson et al., 2003). Although each component of the mammalian coagulation network has unique functional properties, available data based on gene organizations, protein structure, and sequence analysis suggest that it may have resulted from the reduplication and diversification of two gene structures over 400 million years ago. A vitamin K–dependent serine protease is composed of a γ-carboxylated glutamic acid (GLA) epidermal growth factor-like (EGF) 1–EGF 2-serine protease domain structure common to fVII, fIX, fX, and protein C, and the A1-A2-B-AB-C1-C2 domain structure common to fV and fVIII. Prothrombin is also a vitamin K–dependent serine protease; however, it contains kringle domains rather than EGF domains (suggesting a replacement during gene duplication and shuffling). Analyses of active site function amino acid residues reveal distinguishing characteristics of thrombin from other serine proteases, supporting its position as the ancestral blood enzyme (Krem and Cera, 2002; McLysaght et al., 2002). The rapid transformation of fluid blood to a gel-like substance (clot) has been a topic of great interest to scientists, physicians, and philosophers since the days of Plato and Aristotle ( Jewett, 1892; Lee, 1952). However, it was not until the beginning of the 18th century that blood clotting (coagulation) was appreciated as a means to stem blood loss from wounds (hemostasis) (Petit, 1731). As with other areas of science, the microscope played a pivotal role in the understanding of coagulation. In the mid-17th century, Marcello Malpighi separated the individual components of a blood clot into fibers, cells, and serum (Forester, 1956).

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Conference papers on the topic "Fibrin clot properties"

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Purohit, Prashant K. "Fibrin Networks Sustain Large Extensions Due to Unfolding Proteins." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13125.

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Blood clots and thrombi consist primarily of a mesh of branched fibers made of the protein fibrin. We show how these networks give rise to the remarkable extensibility and elasticity of blood clots by determining structural and mechanical properties of the clot at the network, fiber, and molecular levels. The force required to stretch a clot initially rises almost linearly and is accompanied by a dramatic decrease in the clot volume. These macroscopic changes are accompanied by fiber alignment and bundling following forced protein unfolding. We develop constitutive models to integrate observat

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Zamarrón, C. "BINDING OF NATIVE PLASMINOGEN TO FIBRIN AND TO SOME FI BRINOGEN/FIBRIN DERIVATIVES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644832.

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In the fibrinolytic process: (a) fibrin provides a surface on which the major reactions of fibrinolysis occurs: the conversion of plasminogen to plasmin, the cleavage of fibrin by plasmin and the inhibition of plasmin by α2-antiplasmin, (b) some fibrinogen derivatives (e.g. the cyanogen bromide digested fibrinogen fragment denominated FCB-2) can exert stimulatory properties on the plasminogen activation and (c) the initial cleavage of fibrin by plasmin increases the rate conversion of plasminogen to plasmin.The purpose of the present work has been to correlate these three aspects of the fibrin

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Johannessen, M., F. E. Nielsen, K. Pingel, and L. C. Petersen. "FIBRINOLYTIC EFFECT OF ONE-CHAIN TTSSUE-TYPE PLASMINOGEN ACTIVATOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644406.

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The fibrinolytic properties of authentic one- and two-chain recombinant tPA were compared to those of a plasmin resistant one-chain tPA analogue, tPA-Gly275, which is point mutated in Arg275 of the activation site. The proteins were characterised by reversed phase HPLC, reduced SDS-PAGE, and their concentrations determined by the BCA (modified Lowry) method. When equivalent conc. of these enzymes were tested for fibrinolytic activity by means of clot lysis and fibrin plate lysis methods, the values found for two-chain tPA were consistently 50% higher than one-chain tPA forms. The time course f

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LAU, H. K. F. "PROPERTIES OF A HUMAN FIBRINOGEN A α-CHAIN DEGRADATION FRAGMENT". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643333.

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A fragment of human fibrinogen was obtained by a 30-min digest of fibrinogen with plasmin. The reaction was terminated by 10 mM diisopropyl fluorophosphate and the fragment obtained by sequential gel filtrations on Sephacryl S-200 and Bio Gel P-30. This fragment displayed a single band on both reduced and nonreduced SDS polyacrylamide electrophoreses with a relative Mr of ∼25,000. It did not crossreact with antisera against fibrinogen, fragment D or fragment E and suggested its sequestered location in native fibrinogen. An antiserum raised against this fragment reacted with the fragment itself

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Shih, Cho-Chiang, Ting-Yu Liu, and Chih-Chung Huang. "In vitro assessments of viscoelastic properties of fibrin clot by using acoustic radiation force on a solid sphere." In 2010 IEEE Ultrasonics Symposium (IUS). IEEE, 2010. http://dx.doi.org/10.1109/ultsym.2010.5935691.

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Iga, Y., K. Tanaka, M. Tsukada, S. Kameyama, S. Morichi, and T. Suyama. "Thrombolytic Properties of Pro-Urokinase, Plasminogen Proactivator (PPA)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643031.

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Thrombolytic properties of highly purified plasminogen proactivator (PPA) isolated from culture medium of human kidney cells were compared with those of human urinary urokinase(u-UK). When 125-I-PPA or u-UK was added to whole blood perfusion medium containing preformed thrombi made from whole blood by Chandler loop method, the rates of uptake by the thrombi of PPA and u-UK for 4 hrs were only 2.5% and 2.7% respectively. Using the same thrombi and perfusion medium, an in vitro thrombolytic effect of PPA was examined over a 4 hr period. In early perfusion time, a lag phase was observed in the ly

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Achyuthan, K. E., M. J. Borowitz, M. A. Shuman, and C. S. Greenberg. "THROMBIN INDEPENDENT TRANSGLUTAMINASE IN VASCULAR CELLS AND TISSUES MAY PROVIDE AN ALTERNATE PATHWAY TOWARD CLOT STABILIZATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643775.

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Blood coagulation Factor XIIla (FXIIIa) is a thrombin activated transglutaminase (TG) that is involved in the final step of fibrin stabilization. FXIIIa inhibits fibrinolysis by crosslinking α-2-plasmin inhibitor (α-2-PI) to fibrin. A thrombin-independent TG has been identified in vascular cells and tissues -from human, rabbit, rat, porcine and bovine sources. The vascular TG had several properties similar to the well characterized guinea pig liver TG. Both enzymes had similar molecular weights (80-90 kDa) and similar chromatographic and electrophoretic properties. Both enzymes preferentially

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Lijnen, H. R., L. Nelles, G. Lemmens, D. Collen, and W. E. Holmes. "A FUSION PROTEIN OF THE A-CHAIN OF t-PA WITH LOW Mr scu-PA COMBINES THE FIBRIN-SPECIFICITY OF BOTH MOLECULES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643943.

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A hybrid human cDNA was constructed by ligation of a cDNA fragment of tissue-type plasminogen activator (t-PA), encoding 5∲-untranslated, the pre-pro region and amino acids Ser 1 through Thr 263, with a cDNA fragment of urokinase-type plasminogen activator (u-PA), encoding amino acids Leu 144 through Leu 411. The hybrid cDNA was expressed in Chinese Hamster Ovary Cells and the translation product purified from the conditioned cell culture media in the presence of aprotinin. On SDS-gel electrophoresis under reducing conditions, the protein migrated as a single band with approximate Mr 70,000 an

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Collen, D. "SYNERGISM, MUTANTS AND HYBRIDS OF TISSUE-TYPE PLASMINOGEN ACTIVATO(t-PA) AND SINGLE CHAIN UROKINASE-TYPE PLASMINOGEN ACTIVATOR(scu-PA):POTENTIAL FORTHROMBOLYTIC THERAPY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643725.

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With the development and clinical investigation of the fibrin-specific thrombolytic agents t-PA and scu-PA, many questions relating to their optimal use remain to be answered. It is, however, becoming apparent that these agents, in addition to several advantages,suffer some shortcomings, e.g. their therapeutic dose is large and their fibrin-specificity is limited.Therefore,the quest for better thrombolytic agents remains open.We will report results of four main lines of research which we are pursuing to obtain better agents or regimens for fibrin-specific thrombolytic therapy.1. Synergism betw

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Broeseker, T. A., M. D. P. Boyle, and R. Lottenberg. "PATHOGENIC BACTERIA HAVE HIGH AFFINITY RECEPTORS SPECIFIC FOR PLASMIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644391.

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Binding of the key fibrinolytic enzyme, plasmin, to certain pathogenic group A streptococci was studied. In these experiments the ability of a group A streptococcal strain, 64/14, to bind either 125I-human plasminogen or the same label following activation with urokinase was measured. It was found that this strain bound <10% of the labeled plasminogen but >70% of labeled plasmin. This property distinguishes the plasmin receptor from streptokinase. These bacteria did not express a common serine protease receptor/inhibitor since they failed to bind labeled trypsin or urokinase. Maximal bin

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