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Journal articles on the topic 'Fibrin sealant'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Hutchinson, Richard W., Vince Mendenhall, Randolph M. Abutin, Tim Muench, and James Hart. "Evaluation of Fibrin Sealants for Central Nervous System Sealing in the Mongrel Dog Durotomy Model." Neurosurgery 69, no. 4 (2011): 921–29. http://dx.doi.org/10.1227/neu.0b013e318222ad63.

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Abstract BACKGROUND: Watertight repair of the dura is imperative after neurosurgical procedures involving the brain or spinal cord because inadequately treated leakage of cerebrospinal fluid (CSF) from punctured dura can have serious consequences such as meningitis, arachnoiditis, or epidural abscess. OBJECTIVE: To assess the efficacy of Evicel Fibrin Sealant (Human) to prevent CSF leakage using a 2.0-cm durotomy mongrel dog repair model and to compare the tissue response with Tisseel (a fibrin sealant) and Duraseal (a synthetic polyethylene glycol [PEG] hydrogel sealant). METHODS: The canine

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Torkian, Pooya, Keivan Daneshvar, Ebrahim Taherian, Yasaman Rezaeifar, and Shahram Akhlaghpoor. "Fibrin sealants in lumbar annuloplasty after endoscopic discectomy as a method to prevent recurrent lumbar disc herniation." European Journal of Translational Myology 30, no. 2 (2020): 325–33. http://dx.doi.org/10.4081/ejtm.2020.8748.

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Fibrin sealant as a promising agent for providing scaffold and efficient hemostasis is widely accepted in several specialties. However, the outcome of Fibrin sealants in lumbar annuloplasty after endoscopic discectomy has not been evaluated in patients with disc herniation. The goal of this study was to evaluate the efficacy, response, and probability of future recurrence rates in herniated nucleus pulposus (HNP) with the use of fibrin sealant in conjunction with endoscopic disc surgery. A total of 35 patients (28 men, 7women) were evaluated, including 18 patients who underwent endoscopic disc

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&NA;. "Fibrin sealant." Reactions Weekly &NA;, no. 1194-1195 (2008): 17–18. http://dx.doi.org/10.2165/00128415-200811940-00057.

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&NA;. "Fibrin sealant." Reactions Weekly &NA;, no. 1410 (2012): 23. http://dx.doi.org/10.2165/00128415-201214100-00071.

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Dunn, Christopher J., and Karen L. Goa. "Fibrin Sealant." Drugs 58, no. 5 (1999): 863–86. http://dx.doi.org/10.2165/00003495-199958050-00010.

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6

Jackson, M. R., M. J. MacPhee, W. N. Drohan, and B. M. Alving. "Fibrin sealant." Blood Coagulation & Fibrinolysis 7, no. 8 (1996): 737–46. http://dx.doi.org/10.1097/00001721-199611000-00001.

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7

Martinowitz, Uri, and Renato Saltz. "Fibrin sealant." Current Opinion in Hematology 3, no. 5 (1996): 395–402. http://dx.doi.org/10.1097/00062752-199603050-00011.

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8

Pomini, Karina Torres, Daniela Vieira Buchaim, Jesus Carlos Andreo, et al. "Fibrin Sealant Derived from Human Plasma as a Scaffold for Bone Grafts Associated with Photobiomodulation Therapy." International Journal of Molecular Sciences 20, no. 7 (2019): 1761. http://dx.doi.org/10.3390/ijms20071761.

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Fibrin sealants derived from human blood can be used in tissue engineering to assist in the repair of bone defects. The objective of this study was to evaluate the support system formed by a xenograft fibrin sealant associated with photobiomodulation therapy of critical defects in rat calvaria. Thirty-six rats were divided into four groups: BC (n = 8), defect filled with blood clot; FSB (n = 10), filled with fibrin sealant and xenograft; BCPBMT (n = 8), blood clot and photobiomodulation; FSBPBMT (n = 10), fibrin sealant, xenograft, and photobiomodulation. The animals were killed after 14 and 4

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Spotnitz, William D., and Sandra Burks. "State-of-the-Art Review: Hemostats, Sealants, and Adhesives II: Update As Well As How and When to Use the Components of the Surgical Toolbox." Clinical and Applied Thrombosis/Hemostasis 16, no. 5 (2010): 497–514. http://dx.doi.org/10.1177/1076029610363589.

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The goal of this submission is to describe how and when to best use hemostats, sealants, and adhesives as well as to compare their characteristics and to update the surgical toolbox with respect to any new products approved by the Food and Drug Administration (FDA) as of this date (November 2009). The materials will be presented in 3 major groups each containing specific categories: (1) hemostats; mechanical, active, flowable, and fibrin sealant, (2) sealants; fibrin sealant, polyethylene glycol polymer, and albumin and glutaraldehyde, (3) adhesives; cyanoacrylate, albumin and glutaraldehyde,

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Correa, Maria Elvira P., Oslei P. Almeida, Danyel Peres, et al. "Influence of Homemade and Commercial Fibrin Sealant on Alveolar Bone Healing - an Experimental Study." Blood 104, no. 11 (2004): 4110. http://dx.doi.org/10.1182/blood.v104.11.4110.4110.

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Abstract The beneficial aspects of fibrin sealants for soft tissues are well documented, but studies of their direct influence on bone healing and their effectiveness in augmenting bone graft healing have produced conflicting results. The aim of this study was to evaluate the influence of fibrin sealants (FS) in the alveolar bone healing process during a period of up to 28 days. Seventy-five Wistar rats were submitted to a superior incisor extraction after intramuscular anesthesia (kentamine chloridrate 10% – 10mg/kg and tiazina chloridrate-5mg/kg). The rats were divided into tree different gr

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Mandell, Samuel P., and Nicole S. Gibran. "Fibrin sealants: surgical hemostat, sealant and adhesive." Expert Opinion on Biological Therapy 14, no. 6 (2014): 821–30. http://dx.doi.org/10.1517/14712598.2014.897323.

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Saricam, Murat. "Efficacy of homologous fibrin sealant in the surgery for pneumothorax." International Journal of Research in Medical Sciences 8, no. 6 (2020): 2228. http://dx.doi.org/10.18203/2320-6012.ijrms20202272.

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Background: Prolonged air leakage following pneumothorax surgery is a significant issue causing increased hospital stay and morbidity. This study aimed to investigate the cost and efficacy of homologous fibrin sealant in preventing the air leakages.Methods: Among the patients who had undergone bullectomy and subtotal parietal pleurectomy for recurrent primary spontaneous pneumothorax via transaxillary mini thoracotomy between 2010 and 2018, two groups each including 35 cases were conducted as to whether fibrin sealent had been applied. These two patient groups were compared in terms of age, ge

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Randelli, F., L. Banci, V. Ragone, M. Pavesi, and G. Randelli. "Effectiveness of Fibrin Sealant after Cementless Total HIP Replacement: A Double-Blind Randomized Controlled Trial." International Journal of Immunopathology and Pharmacology 26, no. 1 (2013): 189–97. http://dx.doi.org/10.1177/039463201302600118.

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Fibrinogen-based sealants have been used to improve hemostasis after total hip replacement (THR) with conflicting results. We therefore conducted a double-blind randomized controlled trial to determine whether the commercially available fibrin sealant Quixil is effective in reducing the volume of red blood cell transfusions, postoperative blood loss and postoperative hemoglobin drop. Patients with coxarthrosis scheduled for primary cementless THR, were enrolled in a single hospital setting and randomized to either a fibrin sealant group (n=35) or a negative control group (n=35). The surgeon wa

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Langer, Samantha, J. Michael Guenther, and L. Andrew Difronzo. "Does Fibrin Sealant Reduce Drain Output and Allow Earlier Removal of Drainage Catheters in Women Undergoing Operation for Breast Cancer?" American Surgeon 69, no. 1 (2003): 77–81. http://dx.doi.org/10.1177/000313480306900117.

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Serosanguinous drainage after mastectomy and axillary lymph node dissection has traditionally been treated with the temporary use of closed suction drainage catheters. Use of drainage catheters is associated with wound infection, discomfort, nerve injury, and impaired arm movement. Commercially produced fibrin sealant has been proposed to reduce postoperative serosanguinous collections. We hypothesized that the intraoperative application of low-dose (2–5 cm3) fibrin sealant would reduce serosanguinous drainage and allow earlier removal of closed suction drainage catheters after operation for b

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Spotnitz, William D. "Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective." ISRN Surgery 2014 (March 4, 2014): 1–28. http://dx.doi.org/10.1155/2014/203943.

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Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current fibrin sealant products and their approved uses and a comprehensiv

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Kwa, Kelly AA, Anouk Pijpe, Dirk de Korte, Annabel Snoeks, Roelf S. Breederveld, and Annebeth Meij-de Vries. "Using fibrin sealant for skin graft fixation to avoid sedation in children with burns: a prospective study." Journal of Wound Care 29, no. 11 (2020): 642–48. http://dx.doi.org/10.12968/jowc.2020.29.11.642.

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Objective: To investigate whether a fibrin sealant, Fitrix (Sanquin Blood Supply Foundation, The Netherlands), for fixation of skin grafts in children with burn wounds is less invasive and equally effective in comparison with skin staples. Method: A single-centre prospective observational cohort study was conducted. Children requiring skin grafting after burns were included and received the fibrin sealant. This group was compared with a retrospective control group of children whose skin grafts were fixed with skin staples. Study outcomes were graft take, graft dislocation, other wound complica

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Penov, Kiril, Dejan Radakovic, Seymur Karimli, and Ivan Aleksic. "Fibrin Sealant Patch for the Management of Intractable Bleeding From an LVAD Apex Cannula." Heart Surgery Forum 24, no. 6 (2021): E1052—E1053. http://dx.doi.org/10.1532/hsf.4081.

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Background: Intractable bleeding from the apical cannulation site of a left ventricular assist device (LVAD) is a dreaded complication. Case report: A 52-year-old male suffering from dilative cardiomyopathy (DCM) with fixed pulmonary hypertension underwent reoperative LVAD implantation after previous mitral valve surgery. The patient underwent three rethoracotomies for bleeding from the apex cannulation site without achieving hemostasis. Conventional techniques and application of fibrin sealants and polymeric sealing devices did not fix the problem. The bleeding stopped after application of th

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Avni Shah, Viqar Ahmed, Piyush Patel, Bhavin Trivedi, and Vidya Sagar. "Corroboration Development and Regulatory approval of Fibrin Sealant." International Journal of Drug Regulatory Affairs 9, no. 1 (2021): 1–9. http://dx.doi.org/10.22270/ijdra.v9i1.445.

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Objective Finding the relation between scientific evidence development and regulatory approval of medical devices in existing markets, USA (United states of America) and EU (European Union) Design To understand this relation, we used evidence development of fibrin sealant as a case study. In general fibrin sealant is a good case study because there is a lot of information available about it. A systematic review method based on the Cochrane handbook was used to find the evidence development regarding fibrin sealant. We investigated different indications of fibrin sealant

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Jacob, Shaju, and Sonia Nath. "Fibrin Sealant: A Review of Its Applications in Periodontal Surgery." International Journal of Experimental Dental Science 4, no. 1 (2015): 40–46. http://dx.doi.org/10.5005/jp-journals-10029-1093.

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ABSTRACT Aim Fibrin sealant is a biological tissue adhesive mimicking the final stage of coagulation. It has a wide variety of application in the field of periodontics. The aim of this article was to review current applications and identify potential use of fibrin sealant in periodontal surgical procedures on an evidence-based conclusion. Materials and methods An online search was performed in PubMed, Google Scholar and Cochrane Library databases using keywords fibrin sealant, fibrin glue, fibrin, regeneration, wound healing, tissue adhesive, gingival recession/therapy, surgical therapy, perio

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Helgerson, S., K. Bittner, and R. Spaethe. "Fibrin Sealant Biomatrix Technology." International Journal of Artificial Organs 25, no. 7 (2002): 638–39. http://dx.doi.org/10.1177/039139880202500719.

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Clark, Richard. "Fibrin glue for wound repair: facts and fancy." Thrombosis and Haemostasis 90, no. 12 (2003): 1003–6. http://dx.doi.org/10.1160/th03-08-0526.

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SummaryIn wound repair, fibrin has a multiplicity of activities, some of which are intrinsic to the protein itself and some attributable to other blood constituents associated with the fibrin clot. Fibrin sealants, which have been approved for hemostasis in the US and Europe, are occasionally used wounds to promote healing. However, inconsistency exists in the literature regarding the benefit of these preparations in the healing process. Morecrude fibrinogen preparations, such as cryoprecipitates made from the patient’s own blood on location, appear from the literature to have better utility i

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Fezza, John J., Mont J. Cartwright, William Mack, and Patrick Flaharty. "The Use of Fibrin Sealant in Facelift Surgery." American Journal of Cosmetic Surgery 19, no. 4 (2002): 219–22. http://dx.doi.org/10.1177/074880680201900402.

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Purpose: To report the use of fibrin sealant in facelift surgery. Methods: A prospective study of 40 individuals was performed comparing individuals undergoing facelift surgery with and without the use of fibrin sealant. Patients were enrolled in 2 groups: 20 patients underwent facelifts without fibrin glue, and 20 patients with the use of fibrin glue. The amount of bruising and edema was compared in the 2 groups, as was the incidence of complications, such as hematomas. Operating time was also assessed in the 2 groups. Results: The patients who underwent the procedure with fibrin sealant had

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Ito, Kiyoshi, Tetsuyoshi Horiuchi, Kiyomitsu Oyanagi, Tetsuo Nomiyama, and Kazuhiro Hongo. "Comparative study of fibrin and chemical synthetic sealant on dural regeneration and brain damage." Journal of Neurosurgery: Spine 19, no. 6 (2013): 736–43. http://dx.doi.org/10.3171/2013.8.spine12998.

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Object Several materials, such as polyethylene glycol (PEG) hydrogel and fibrin glue, have been used to seal dural incisions after brain and spinal surgeries. Although the use of PEG sealant is gaining popularity, it can be associated with postoperative cerebrospinal fluid leakage and infection. However, the reasons for this association are currently unknown. The present study aimed to investigate the effects of PEG sealant and fibrin glue on wound healing and brain damage in vivo. Methods Oval-shaped bone defects and dural defects were created bilaterally over the parietal lobes of 22 Japanes

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Squires, Reina. "Fibrin sealant as a delivery vehicle for cells, antibiotics, growth factors, and painkillers." Journal of Applied Biotechnology & Bioengineering 10, no. 2 (2023): 56–64. http://dx.doi.org/10.15406/jabb.2023.10.00328.

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Fibrin sealant has vast uses in surgical settings for both cellular and noncellular delivery. Some advantages include biocompatibility, ability to support cell attachment, and controlled degradation rate. There are many clinical applications, from wound healing to improving bone defects to being used as an adjunct to surgery. It can also serve as a suitable delivery vehicle for cells, steroids, antibiotics, growth factors, chemotherapeutic agents, and painkillers. The composition of fibrin sealant can be altered to allow for controlled release, making it an attractive delivery system. Lastly,

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CWALIŃSKI, Jarosław, Jacek HERMANN, Jacek PASZKOWSKI, and Tomasz BANASIEWICZ. "Endoscopic vacuum assisted closure of gastrocutaneous fistula after sleeve gastrectomy combined with fibrin sealant." Journal of Experimental and Clinical Medicine 38, no. 3 (2021): 398–401. http://dx.doi.org/10.52142/omujecm.38.3.39.

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Treatment of gastrointestinal fistulas after staple line leaks is difficult and non-invasive procedures such as endoclips, stents or endoscopic vacuum assisted closure (E-VAC) are sometimes not adequate. Fibrin sealants (FS) may promote healing, although today are used mainly to prevent anastomosis dehiscence within digestive tract. The authors present a 37-year-old female patient who developed a chronic gastrocutaneous fistula after sleeve gastrectomy for severe obesity treated successfully with a combination of E-VAC and a fibrin sealant. Long term peritoneal drainage, total parenteral nutri

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Kim, Hwa Cheong, Chahien Choi, and Woo Young Kim. "Effectiveness of Fibrin Sealant Patch in Reducing Drain Volume after Pelvic Lymph Node Dissection in Women with Gynecologic Malignancy." BioMed Research International 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/3086857.

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Background. The goal of this study was to evaluate the effectiveness of fibrin sealant in decreasing postoperative lymphatic drainage in women after pelvic lymphadenectomy and/or para-aortic lymphadenectomy during gynecologic cancer surgery. Methods. This study is a retrospective case-control study. Forty-five patients who underwent staging surgery were enrolled. Twenty-seven patients were in the fibrin sealant group (group A) and 18 in the control group (group B). The two groups were compared for the total volume of drain, hospital stay, harvested lymph node, and incidence of asymptomatic lym

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Fischer, Craig P., Christopher G. Wood, Jessica Shen, et al. "A Randomized Trial of Aprotinin-Free Fibrin Sealant Versus Absorbable Hemostat." Clinical and Applied Thrombosis/Hemostasis 17, no. 6 (2011): 572–77. http://dx.doi.org/10.1177/1076029611404212.

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Background: This study evaluated the safety and hemostatic effectiveness of a tranexamic acid- and aprotinin-free fibrin sealant versus an absorbable hemostat in soft tissue during elective retroperitoneal or intra-abdominal surgery. Materials and Methods: This randomized, active-controlled, multicenter study enrolled patients who were undergoing elective retroperitoneal or intra-abdominal surgery and required adjunctive hemostatic measures at the target bleeding site (TBS). Patients were randomized (time = 0 minutes) to receive fibrin sealant or absorbable hemostat. The primary endpoint was t

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de Matos Bourguignon Filho, Aguimar, Renato Schroder dos Santos, José Renato Costa, André Alberto Cãmara Puppin, Robson Almeida de Rezende, and Gilson Correia Beltrão. "Oral Surgery with Fibrin Sealants in Patients with Bleeding Disorders: A Case Report." Journal of Contemporary Dental Practice 7, no. 3 (2006): 106–12. http://dx.doi.org/10.5005/jcdp-7-3-106.

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Abstract Surgical treatment of patients with bleeding disorders requires careful planning. The use of fibrin sealants following a dental extraction in a patient with von Willebrand's disease is presented in this report. A female patient with von Willebrand's disease had an extraction of a maxillary right third molar. After evaluation by the surgeon and the hematologist, the surgery was performed with a topical application of fibrin sealant and systemic administration of antifibrinolytic drugs. Hemostasis was obtained without replacement of plasma clotting factor. New techniques of achieving he

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Vedhapoodi, Ashwin Gajendran, Aravind Sabesan, Benazir Ferozkhan, et al. "Regenerated Oxidized Cellulose as a Sealant and Adhesive in Endoscopic Endonasal Skull Base Reconstruction." International Archives of Otorhinolaryngology 29, no. 02 (2025): 001–10. https://doi.org/10.1055/s-0044-1788599.

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Abstract Introduction An ideal and long-lasting adhesive and sealant is essential during endoscopic endonasal skull-base surgery to hold the reconstruction intact and prevent cerebrospinal fluid (CSF) permeation until complete healing occurs. Fibrin glue is the most common material used. Regenerated oxidized cellulose (ROC) has not been mentioned in the literature as sealant and adhesive, and, hence, we intended to study this role. Objective To evaluate the role of ROC as tissue sealant and adhesive in the reconstruction of skull-base defects in endoscopic endonasal skull-base surgery. Methods

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Kuskucu, Mesih, Mahir Mahirogullari, Can Solakoglu, et al. "Treatment of Rupture of the Achilles Tendon with Fibrin Sealant." Foot & Ankle International 26, no. 10 (2005): 826–31. http://dx.doi.org/10.1177/107110070502601007.

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Background: The optimal management strategy for acute Achilles tendon ruptures is controversial. These injuries historically were treated by nonoperative methods (cast immobilization, bandaging); however, operative repair of the ruptured tendon has become popular. Methods: Thirty-two patients who had rupture of the Achilles tendon were treated operatively with use of fibrin sealant, and clinical and functional performance measures were assessed after a mean followup of at least 6 months between November, 1998, and July, 2003. All of the patients were male. Average age was 38.18 (30 to 45) year

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Gasparri, Maria Luisa, Ilary Ruscito, Daniele Bolla, Pierluigi Benedetti Panici, Michael D. Mueller, and Andrea Papadia. "The Efficacy of Fibrin Sealant Patches in Reducing the Incidence of Lymphatic Morbidity After Radical Lymphadenectomy: A Meta-Analysis." International Journal of Gynecologic Cancer 27, no. 6 (2017): 1283–92. http://dx.doi.org/10.1097/igc.0000000000001051.

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BackgroundAlthough pivotal in the oncological management of most tumors, radical lymphadenectomy is associated with a significant number of lymphatic complications. The aim of this meta-analysis is to evaluate the efficacy of fibrinogen sealant patches in reducing lymphadenectomy-related postoperative complications.Methods/MaterialsThe electronic databases PubMed, Medline, and Scopus were searched using the terms “lymphadenectomy” or “lymph node dissection” and “TachoSil,” “TachoComb,” or “fibrin sealant patch.” Series evaluating the efficacy of fibrin-thrombin collagen sealant patches were in

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Zhang, Yuhan. "Applications of Fibrin Tissue Sealant." IOP Conference Series: Earth and Environmental Science 632 (January 14, 2021): 052098. http://dx.doi.org/10.1088/1755-1315/632/5/052098.

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Erba, Paolo, Pietro di Summa, Reto Wettstein, Wassim Raffoul, and Daniel Kalbermatten. "Fibrin Sealant for Fasciocutaneous Flaps." Journal of Reconstructive Microsurgery 26, no. 04 (2010): 213–17. http://dx.doi.org/10.1055/s-0030-1247716.

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SCHLAG, GONTHER, and HEINZ REDL. "Fibrin Sealant in Orthopedic Surgery." Clinical Orthopaedics and Related Research &NA;, no. 227 (1988): 269???285. http://dx.doi.org/10.1097/00003086-198802000-00033.

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Manabe, Yasuhiro, Tomitaka Kubo, Shinya Wakui, Sachio Yoshida, and Hitoshi Saito. "Fibrin Sealant Used in Tonsillectomy." Practica Oto-Rhino-Laryngologica 84, no. 9 (1991): 1279–82. http://dx.doi.org/10.5631/jibirin.84.1279.

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Knox Cartwright, Nathaniel E., and Derek M. Tole. "Potential complication of fibrin sealant." Journal of Cataract & Refractive Surgery 34, no. 6 (2008): 881–82. http://dx.doi.org/10.1016/j.jcrs.2008.02.026.

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Nakajima, Satoshi, Tadaharu Fukuda, Masamichi Hasue, Yuichi Sengoku, Jo Haraoka, and Takanori Uchida. "New Technique for Application of Fibrin Sealant: Rubbing Method Devised to Prevent Cerebrospinal Fluid Leakage from Dura Mater Sites Repaired with Expanded Polytetrafluoroethylene Surgical Membranes." Neurosurgery 49, no. 1 (2001): 117–23. http://dx.doi.org/10.1097/00006123-200107000-00018.

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Abstract OBJECTIVE The effectiveness of a strong, pressure-tight method for fibrin sealant application was experimentally and clinically evaluated, using expanded polytetrafluoroethylene (ePTFE) surgical membranes. METHODS Two application methods were examined in two groups. For Group 1, 1 ml each of Solutions A and B was simply sprayed over the surface (spray method). For Group 2, a small amount of Solution A was rubbed into the sutured site and then Solutions A and B were sprayed over the surface (rubbing method). In the experimental study, a moment pressure elevation test and a continuous s

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Kvan, O. K., and N. B. Teryaeva. "Clinical application of fi brin sealant." Clinical Medicine (Russian Journal) 103, no. 3 (2025): 187–95. https://doi.org/10.30629/0023-2149-2025-103-3-187-195.

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Fibrin sealants in surgery has been used for a long time as a tool for hemostasis and perioperative bleeding preventing. The appropriateness of fi brin glue to diff erent surgical strategies infl uences the clinical outcome. Numerous studies on biological and synthetic adhesive compositions show that there is still limited data on how diff erences in fi brin sealant formulations relate to their clinical eff ectiveness and safety. The review is an attempt to summarize information on biological adhesives including the history of implementation of fi brin glue in surgery, gelation and adhesion me

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Sojo, Ernesto T., Monica D. Grosman, Marta L. Monteverde, Marcela M. Bailez, and Norma Delgado. "Fibrin Glue is Useful in Preventing Early Dialysate Leakage in Children on Chronic Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 24, no. 2 (2004): 186–90. http://dx.doi.org/10.1177/089686080402400211.

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Objective To assess if application of fibrin glue sealant to the peritoneal cuff suture is useful in the prevention of early dialysate leakage in children with end-stage renal disease on chronic peritoneal dialysis (CPD). Design Single-center, open-label, prospective randomized study. Setting University Pediatric Hospital. Methods 52 catheters were implanted in 45 children (mean age 6.2 ± 4.5 years). Catheters were randomly assigned to either the control group or the sealant group. In the latter group, 1 mL of fibrin glue sealant was applied to the peritoneal cuff suture. 18 catheters were use

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Reshmi, T. S., Shashikanth Hegde, K. S. Rajesh, Vinita Boloor, and Anupama Rao. "A Comparative Clinical Study to Evaluate the Healing of Surgical Periodontal Wound Closure using Fibrin Glue and Silk Suture." Journal of Multidisciplinary Dental Research 10, no. 2 (2024): 50–55. https://doi.org/10.38138/jmdr/v10i2.24.

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Aim of this study is to compare the healing of surgical periodontal wound closure using Fibrin glue and Surgical silk suture. A total of ten subjects aged 25-54 years were divided into 2 groups; Group I where surgical flap closure was done with Fibrin glue on one sextant and Group II where surgical flap closure was done with Silk Suture on other sextant. Time taken for flap closure was recorded on the day of procedure. Post-operative clinical parameters pain, wound healing index and plaque index were recorded at 1st week, 4th week and 12th week for both groups. On inter-group comparison, stati

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Stanisce, Luke, Michael Lai, Nadir Ahmad, et al. "Outcomes Associated With Fibrin Sealant Use in Lateral Neck Dissections." OTO Open 4, no. 4 (2020): 2473974X2098102. http://dx.doi.org/10.1177/2473974x20981021.

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Objective To determine whether the use of fibrin sealant tissue adhesives during lateral neck dissections is associated with a change in postoperative outcomes. Study Design Retrospective cohort. Setting Institutionally affiliated tertiary care center. Methods Various demographic, disease, and surgical data were collected for patients who underwent lateral neck dissections. Univariate regression analysis was performed with the following outcomes: total drain output and duration of drain placement, as well as incidence of postoperative infection, hematoma, seroma, chyle leak, and salivary leak.

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de Barros, Caio Nunes, Ana Lúcia Miluzzi Yamada, Rui Seabra F. Junior, et al. "A new heterologous fibrin sealant as a scaffold to cartilage repair—Experimental study and preliminary results." Experimental Biology and Medicine 241, no. 13 (2015): 1410–15. http://dx.doi.org/10.1177/1535370215597192.

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Autologous fibrin gel is commonly used as a scaffold for filling defects in articular cartilage. This biomaterial can also be used as a sealant to control small hemorrhages and is especially helpful in situations where tissue reparation capacity is limited. In particular, fibrin can act as a scaffold for various cell types because it can accommodate cell migration, differentiation, and proliferation. Despite knowledge of the advantages of this biomaterial and mastery of the techniques required for its application, the durability of several types of sealant at the site of injury remains questio

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Vaiman, Michael, Ephraim Eviatar, and Samuel Segal. "Effectiveness of second-generation fibrin glue in endonasal operations." Otolaryngology–Head and Neck Surgery 126, no. 4 (2002): 388–91. http://dx.doi.org/10.1067/mhn.2002.123345.

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We evaluated the efficacy and safety of the Quixil fibrin sealant after its application to endonasal operative sites. A total of 153 patients underwent nasal surgery. The rate of hemorrhagic complications was compared in the group with nasal packing and in the group in whom fibrin glue was used to stop postoperative bleeding. Our results indicate that the application of Quixil fibrin glue to the operative sites in various endonasal operations provides effective hemostasis and sealing. This fibrin glue is a more effective hemostatic agent than foam nasal packing and provides no complications, a

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Kulkarni, Apoorva, Vishesh Dikshit, Abhaya Gupta, Paras Kothari, Shalika Jayaswal, and Geeta Kekre. "Use of fibrin sealant and tunica vaginalis flap in the repair of urethro-cutaneous fistulas: experience in a tertiary care centre." International Surgery Journal 5, no. 7 (2018): 2497. http://dx.doi.org/10.18203/2349-2902.isj20182761.

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Background: Urethro-cutaneous (UC) fistulas are one of the most common complications after hypospadias surgery. To repair a UC fistula, an experienced surgeon with vast knowledge in the field of hypospadias is essential. Various techniques of UC fistula repair have been described. We share our experience in the use of fibrin sealant and tunica vaginalis flap as intermediate cover in UC fistula repairs.Methods: Our objective was to evaluate the efficacy of fibrin sealant and tunica vaginalis flap in urethro-cutaneous fistula repair in those patients where dartos flap is not available. Total 40

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Edwards, Steven J., Fay Crawford, Michelle Helena van Velthoven, et al. "The use of fibrin sealant during non-emergency surgery: a systematic review of evidence of benefits and harms." Health Technology Assessment 20, no. 94 (2016): 1–224. http://dx.doi.org/10.3310/hta20940.

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BackgroundFibrin sealants are used in different types of surgery to prevent the accumulation of post-operative fluid (seroma) or blood (haematoma) or to arrest haemorrhage (bleeding). However, there is uncertainty around the benefits and harms of fibrin sealant use.ObjectivesTo systematically review the evidence on the benefits and harms of fibrin sealants in non-emergency surgery in adults.Data sourcesElectronic databases [MEDLINE, EMBASE and The Cochrane Library (including the Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, the Health Technology Asse

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Greenberg, James, Julian Robinson, Jean Carabuena, Michaela Farber, and Daniela Carusi. "Use of a Fibrin Sealant Patch at Cesarean for Conservative Management of Morbidly Adherent Placenta." American Journal of Perinatology Reports 08, no. 04 (2018): e325-e327. http://dx.doi.org/10.1055/s-0038-1675848.

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Background Morbidly adherent placenta represents a surgical challenge and source of maternal morbidity and mortality. We report the use of a fibrin sealant patch to address hemorrhage associated with a morbidly adherent placenta during cesarean delivery. Case A patient underwent repeat cesarean delivery with complete anterior placenta previa and anticipated morbidly adherent placenta. Bleeding persisted following delivery and removal of the placenta, despite uterine artery embolization. A fibrin sealant patch was applied as an adjuvant intervention to the placental bed and hemostasis was achie

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Lewis, Kevin M., Jeff McKee, Alexandra Schiviz, Alexander Bauer, Martin Wolfsegger, and Andreas Goppelt. "Randomized, Controlled Comparison of Advanced Hemostatic Pads in Hepatic Surgical Models." ISRN Surgery 2014 (March 4, 2014): 1–7. http://dx.doi.org/10.1155/2014/930803.

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Blood loss during hepatic surgery leads to poor patient outcomes. This study investigates the hemostatic efficacy of a novel sealing hemostatic pad (polyethylene glycol-coated collagen, PCC) and a fibrin sealant pad (fibrin-thrombin coated collagen, FTC) in a leporine hepatic segmentectomy and a porcine hepatic abrasion model. A segmentectomy was used to compare hemostatic success and hematoma incidence in 20 rabbits (10/group). Hepatic abrasions were used to compare hemostatic success up to 10 min after application in six pigs (42 lesions/group). In the segmentectomy model, PCC achieved 100%

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Düregger, Katharina, Sabrina Frenzel, and Markus Eblenkamp. "Autologous fibrin glue: automated production and adhesive quality." Current Directions in Biomedical Engineering 3, no. 2 (2017): 397–400. http://dx.doi.org/10.1515/cdbme-2017-0083.

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AbstractFibrin glue is a two-component adhesive used to stop bleeding, seal wound edges and for scaffolds in tissue engineering. Autologous products result in reduced risk of contamination and immunological responses compared to commercially available fibrin glue. However, reproducibility due to patient dependent sealant properties of autologous fibrin glue preparation is low. In this study a fully automated production process for both the fibrinogen and thrombin component from small blood volumes was developed. The resulting fibrinogen concentration, thrombin activity and sealant properties o

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Pinto, Daniel Mendes, and Paulo Bastianetto. "Percutaneous treatment of femoral pseudoaneurysms: comparison of fibrin sealant against thrombin." Jornal Vascular Brasileiro 12, no. 4 (2013): 264–70. http://dx.doi.org/10.1590/jvb.2013.049.

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INTRODUCTION: Femoral pseudoaneurysms are a complication that occurs in connection with up to 8% of percutaneous procedures. Of the available treatments, ultrasound guided thrombin injection has a high success rate and is well-tolerated by patients. The combination of thrombin and fibrinogen known as fibrin sealant forms a stable clot and can be used to treat pseudoaneurysms, particularly those with complex anatomy and larger size. OBJECTIVE: To compare the results of treating femoral pseudoaneurysm in two ways: Group T was treated with thrombin alone and Group T+F was treated with fibrin seal

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Perussi Biscola, Natalia, Luciana Politti Cartarozzi, Rui Seabra Ferreira Junior, Benedito Barraviera, and Alexandre Leite Rodrigues de Oliveira. "Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair." Neural Plasticity 2016 (2016): 1–19. http://dx.doi.org/10.1155/2016/9028126.

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Brachial plexus lesion results in loss of motor and sensory function, being more harmful in the neonate. Therefore, this study evaluated neuroprotection and regeneration after neonatal peripheral nerve coaptation with fibrin sealant. Thus, P2 neonatal Lewis rats were divided into three groups: AX: sciatic nerve axotomy (SNA) without treatment; AX+FS: SNA followed by end-to-end coaptation with fibrin sealant derived from snake venom; AX+CFS: SNA followed by end-to-end coaptation with commercial fibrin sealant. Results were analyzed 4, 8, and 12 weeks after lesion. Astrogliosis, microglial react

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