Academic literature on the topic 'Fibrinolise'
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Journal articles on the topic "Fibrinolise"
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Tumpa, Andrea, and Renata Barić Rafaj. "Koagulacijske pretrage u veterinarskoj medicini." Veterinarska stanica 51, no. 5 (July 1, 2020): 571–88. http://dx.doi.org/10.46419/vs.51.5.2.
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Hemostaza je proces zaustavljanja krvarenja. Spontana hemostaza uključuje složene biokemijske mehanizme zgrušavanja krvi, regulirane interakcije između ozlijeđenog tkiva, stijenke krvnih žila i cirkulirajućih trombocita, prokoagulacijskih, antikoagulacijskih te fibrinolitičkih plazmatskih proteina. Proces hemostaze dijelimo na tri faze: primarna, sekundarna te fibrinoliza. Nefunkcionalna primarna hemostaza (trombocitopenija, kao glavni uzrok) za posljedicu ima usporeno i otežano stvaranje trombocitnog ugruška. U slučaju ozljede krv će izlaziti iz krvnih žila nekoliko sekundi ili minuta dok se ne formira stabilan sekundarni hemostatski ugrušak. U slučaju nefunkcionalne sekundarne hemostaze krvarenje se ne primjećuje izravno, već s vremenskim odmakom, najčešće nakon nekoliko minuta. Imajući na umu postajanje različitih faza hemostaze te različite aktivacije koagulacijskih kaskada, razvijene su i različite metode laboratorijskog mjerenja. Ovaj rad navodi i objašnjava koagulacijske pretrage koje se danas primjenjuju u veterinarskoj praksi. Opisana je metoda i svrha svake pretrage uz glavne primjedbe vezane uz uzorkovanje i moguće interferencije. Uzorkovanje krvi za koagulacijske pretrage osjetljivije je od uzorkovanja za ostale pretrage krvi. Nužno je izbjeći aktivaciju trombocita te se iz tog razloga idealnim uzorkovanjem smatra ono kod kojeg je krv vađena bez staze. Većina koagulacijskih pretraga kao uzorak koristi citratnu plazmu siromašnu trombocitima koja se dobiva nakon centrifugiranja (15 minuta na 2000 g) pune krvi vađene uz antikoagulans 3-natrij-citrat-dihidrat (0,11 mol/L). Većina mjerenja osnovnih parametara hemostaze uključuje praćenje stvaranja ugruška (koaguluma), a prati se brzina i sposobnost ili nedostatak sposobnosti grušanja krvi. Danas su metode automatizirane, a vrijeme nastanka ugruška mjeri se elektromehaničkom ili foto-optičkom metodom. Osim mjerenja brzine nastanka ugruška moguće je mjerenje aktivnosti enzima i inhibitora koagulacije te mjerenje koncentracije pojedinih komponenti koagulacijskih kaskada i fibrinolize. U ovim slučajevima koriste se imunokemijske metode koje se temelje na specifičnoj reakciji antigen-antitijelo, pri čemu su od automatiziranih metoda u uporabi najčešće lateks imunoturbidimetrije, a od ručnih metoda ELISA-e. U novije se vrijeme sve više nastoji ispitati poremećaj zgrušavanja u punoj krvi pomoću tromboelastografije. Za razliku od standardnih koagulacijskih testova, tromboelastografija evaluira kinetiku cijelog procesa zgrušavanja, od početnog stvaranja ugruška, polimerizacije fibrina do konačne stabilnosti ugruška. U ispitivanju uzroka krvarenja laboratorijskim pretragama procjenjuje se: rezistencija krvnih žila, broj i funkcija trombocita, unutrašnji i vanjski put zgrušavanja, mehanizam fibrinolize i djelovanje inhibitora zgrušavanja. Laboratorijska dijagnostika poremećaja hemostaze započinje izvođenjem globalnih pretraga. Globalne koagulacijske pretrage su najjednostavnije te istovremeno obuhvaćaju i vanjski i unutarnji put zgrušavanja, a u njih ubrajamo: vrijeme krvarenja, protrombinsko vrijeme, aktivirano parcijalno tromboplastinsko vrijeme, trombinsko vrijeme, broj trombocita i fibrinogen. Nakon globalnih pretraga, u svrhu postavljanja konačne dijagnoze, slijede specifične pretrage aktivnosti i funkcije trombocita, analiza trombocitnih antitijela, a po potrebi i mjerenja koncentracije i aktivnosti pojedinih faktora zgrušavanja i von Willebrandovog faktora te inhibitora zgrušavanja (antitrombin i protein C). Laboratorijski je moguće pratiti i tijek fibrinolize mjerenjem koncentracije razgradnih produkata fibrina i fibrinogena te D-dimera. S obzirom na složenost koagulacijskog sustava, laboratorijsko ispitivanje hemostaze potrebno je provesti u više stupnjeva, počevši od nekoliko globalnih pretraga te barem jedne specifične. Važno je naglasiti da ne postoji ni jedan test koji samostalno daje uvid u funkciju cjelokupnog sustava zgrušavanja.
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Wagner, H. J., E. Starck, H. Alfke, and P. Reuter. "Konventionelle lokale intraarterielle Fibrinolyse, Spraylyse und mechanisch akzelerierte Fibrinolyse." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 159, no. 11 (November 1993): 466–70. http://dx.doi.org/10.1055/s-2008-1032799.
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Witt, I. "Fibrinolyse bei Dysfibrinogenämien." Hämostaseologie 22, no. 02 (2002): 55–56. http://dx.doi.org/10.1055/s-0037-1619541.
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Barthels, M., J. Harenberg, I. Pabinger, K. T. Preissner, and H. Riess. "Fibrinbildung und Fibrinolyse." Hämostaseologie 24, no. 02 (2004): 5–7. http://dx.doi.org/10.1055/s-0037-1619619.
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Dempfle, C. E. "Das TAFI-System." Hämostaseologie 27, no. 04 (2007): 278–81. http://dx.doi.org/10.1055/s-0037-1617094.
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ZusammenfassungZiel der Blutgerinnung ist die Verhinderung eines Blutverlustes. Das Fibrinolysesystem dient dazu, das Produkt der Blutgerinnung, das Fibringerinnsel, zu beseitigen. Eine wichtige Verbindung zwischen Gerinnungsaktivierung und Fibrinolyse ist der Thrombin-aktivierbare Fibrinolyse-Inhibitor (TAFI). TAFI wird durch Thrombin aktiviert, wobei Thrombomodulin als Kofaktor wirken kann. TAFIa hemmt die Aktivierung von Plasminogen und die Proteolyse von Fibrin, indem es vom Fibrin Lysinreste abspaltet, die für die Bindung von t-PA, Plasminogen und Plasmin entscheidend sind. Hohe Thrombinkonzentrationen begünstigen die TAFI-Aktivierung und führen so zu Gerinnseln mit hoher Resistenz gegenüber der Fibrinolyse. Niedrige Thrombinkonzentrationen, bei Patienten mit hämorrhagischer Diathese, oder gerinnungshemmender Therapie, führen zu verminderter TAFIa-Aktivität und damit zu einer gesteigerten Fibrinproteolyse. Aus der Erforschung des TAFI-Systems ergeben sich neue therapeutische Ansätze, sowohl für die Behandlung von Blutungen, als auch für die Behandlung von Thrombosen, Embolien oder disseminierter intravasaler Gerinnung.
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Rohmah, Martina Kurnia, Djelang Zainuddin Fickri, Wahyu Kasifa, and Khurin In Wahyuni. "Uji Aktivitas Fibrinolisis Ekstrak Alkaloid Total Rimpang Lengkuas Merah (Alpinia Purpurata (Vielli) K.Schum) Secara In Vitro." Journal of Pharmaceutical Care Anwar Medika 1, no. 2 (June 30, 2019): 83–95. http://dx.doi.org/10.36932/jpcam.v1i2.12.
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Ketidakseimbangan hemostasis akan meningkatan agregasi trombosit, hiperkoagulasi, dan penurunan aktivitas fibrinolisis yang menyebabkan terbentuknya sumbatan (trombus) pada pembuluh darah. Adanya gangguan tersebut menyebabkan akan menimbulkan sejumlah penyakit seperti Ateroskelrosis, Infark miokard, Iskemia, Stroke dan Diabetes Tipe II. Terapi yang selama ini digunakan diantaranya Streptokinase dan Nattokinase yang memiliki efek samping berupa Perdarahan, sehingga diperlukan penelitian untuk mencari agen fibrinolisis dari bahan alam. Alkaloid merupakan salah satu senyawa yang memiliki aktivitas sebagai fibrinolisis yang menghambat TNF-α agar tidak terjadi sekresi PAI-1 yang menghambat plasminogen sehingga menjadi plasmin yang dapat mendegradasi fibrin. Salah satu tanaman yang memiliki kandungan senyawa alkaloid yaitu rimpang lengkuas merah (Alpinia purpurata (Velli) K.Schum). Penelitian ini bertujuan untuk mengetahui perbedaan dan pengaruh persen fibrinolisis pada pemberian ekstrak alkaloid total Rimpang Lengkuas Merah pada konsentrasi 0,1 mg/ml, 0,5 mg/ml, 1 mg/ml. jenis penelitian ini menggunakan experimental control study dengan rancangan acak lengkap (RAL) pada 25 subjek secara in vitro. Penelitian ini terbagi menjadi tiga tahap. Tahap pertama ekstraksi dan pemisahan alkaloid total Rimpang Lengkuas Merah didapatkan sebanyak 4,2%. Tahap kedua uji fitokimia dengan parameter yang diuji alkaloid positif dan sedangkan flavonoid, tannin dan saponin negatif. Tahap ketiga pengujian aktivitas fibrinolisis dengan banyaknya persen lisis bekuan (fibrinolisis). Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan (p=0,017<0,05) antar kelompok kontrol (Kontrol positif dan negatif) dengan kelompok perlakuan (Alkaloid total ekstrak Rimpang Lengkuas Merah konsentrasi 0,1 mg/ml, 0,5 mg/ml dan 1 mg/ml). Pemberian alkaloid total ekstrak Rimpang Lengkuas Merah memiliki pengaruh (Fhitung =5,180 > Ftabel) dan terdapat hubungan cukup kuat (r=0,473) antar konsentrasi perlakuan terhadap persen fibrinolisis. Aktivitas fibrinolisis yang maksimal terjadi pada konsentrasi 1 mg/ml ekstrak alkaloid total Rimpang lengkuas merah.
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Winther, K. "Fibrinolyse und kardioprotektive Therapie." Hämostaseologie 08, no. 02 (March 1988): 100–101. http://dx.doi.org/10.1055/s-0038-1659868.
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ZusammenfassungNichtselektive ß-Rezeptoren-Blok-kade verlängert die ECLT und vermindert die Aktivität des Gewebe-plasminogenaktivators (3, 4, 7). Selektive ß-Rezeptoren-Blocker verändern die fibrinolytische Aktivität nicht, während Blocker mit ISA entsprechend ihrer ISA-Aktivität die Fibrinolyse beeinflussen. Die Wirkung von Kalziumkanalblockern ist noch nicht ausreichend untersucht. Eine mögliche günstige Wirkung dieser Medikamente auf die fibrinolytische Aktivität bei verschiedenen Gruppen von Patienten kann jedoch nicht ausgeschlossen werden.
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Le Gall, C., M. Dutech, and K. Sarhaoui. "Fibrinolyse de l'embolie pulmonaire." EMC - Cardiologie 3, no. 2 (January 2008): 1–8. http://dx.doi.org/10.1016/s1166-4568(08)31464-8.
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Perneczky, G., R. Karnik, H. Leitner, H. P. Ammerer, and J. Slany. "Lokale Fibrinolyse intrakranieller Gefäßverschlüsse." European Surgery 18, no. 4 (July 1986): 431–34. http://dx.doi.org/10.1007/bf02679860.
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Schubring, C., J. Grulich-Henn, S. Bauer, and G. Müller-Berghaus. "Fibrinolyse bei prämenopausaler Hysterektomie." Archives of Gynecology and Obstetrics 254, no. 1-4 (December 1993): 460–61. http://dx.doi.org/10.1007/bf02266065.
Full textDissertations / Theses on the topic "Fibrinolise"
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Annichino-Bizzacchi, Joyce Maria 1957. "Avaliação de alguns parametros da coagulação sanguinea e fibrinolise em pacientes com mieloma multiplo." [s.n.], 1989. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308731.
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Orientador : Claudio A. M. SampaioTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: O mieloma múltiplo é uma doença neoplásica caracterizada pela proliferação de um clone anormal de plasmócitos, que geralmente sintetizam quantidades anormais' de paraproteína monoclonal. A presença da paraproteína pode interferir com a hemostasia por alterações na função plaquetária, pela infiltração do tecido conectivo impedindo a exposição do cOlageno, pela formação de inibidores ou de complexos inespecíficos com os fatores de coagulação...Observação: O resumo, na integra, podera ser visualizado no texto completo da tese digital
Abstract: Multiple mieloma is a neoplastic disease caracterized by the proliferation of an abnormal cIone of pIasmoc~tes, which enerall synthesize abnormal omounts of monoclonal immunoglobulin. Presence of paraprotein can modif~ the hemostasis through alteration in the pIatelet function, infiltration of the connective tissue interfering with the collagen e~position, formation of specific inhibitors or unespecific comple~es with coagulation factors...Note: The complete abstract is available with the full electronic digital thesis or dissertations
Doutorado
Doutor em Medicina
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Crescencio, Amanda Paulino. "Relação entre as concentrações plasmáticas e peritoneais de dímeros-D e as variáveis clínicas e laboratoriais de equinos com síndrome cólica." Botucatu, 2017. http://hdl.handle.net/11449/152230.
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Orientador: Marcos Jun WatanabeCoorientador: Carlos Alberto Husnni
Banca: Juliana de Moura Alonso
Banca: Paula Alessandra Di Filippo
Resumo: Nos equinos, os distúrbios gastrointestinais (GI) são as causas mais comuns de problemas de coagulação, podendo gerar complicações fatais. Atualmente, uma das ferramentas mais sensíveis para avaliação da hipercoagulabilidade e hiperfibrinólise em cavalos é a determinação das concentrações de dímeros-D. Dessa forma, objetivou-se relacionar as concentrações plasmáticas e peritoneais de dímeros-D com as variáveis clínicas (frequência cardíaca, frequência respiratória, cor das membranas mucosas, tempo de preenchimento capilar, temperatura retal, grau de dor e tempo de evolução do quadro) e laboratoriais (hematócrito, proteína plasmática total, plaquetas, fibrinogênio e leucócitos sanguíneos, além de proteína, fibrinogênio, células nucleadas, bactérias e glicose no líquido peritoneal) de equinos com síndrome cólica e com o diagnóstico e prognóstico desses casos. Foram utilizados 86 equinos com idade mediana de 6,5 anos e com peso mediano de 400 Kg. Os animais foram submetidos ao exame clínico e coleta de amostras de sangue e líquido peritoneal (LP) na admissão. As concentrações plasmáticas e peritoneais de dímeros-D foram avaliadas através de um ensaio semiquantitativo de aglutinação em látex. Apesar das concentrações plasmáticas e peritoneais de dímeros-D terem demonstrado um sentido biológico relacionado à gravidade dos casos de cólica na análise descritiva, isso não foi comprovado estatisticamente através da análise multivariada. Portanto, concluímos que a determinação das conc... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: In horses, gastrointestinal (GI) disorders are the most common cause of coagulation problems, which can lead to fatal complications. One of the most sensitive tools for assessing hypercoagulability and hyperfibrinolysis in horses is the determination of D-dimer concentrations. The aim of this study was to correlate the plasma and peritoneal D-dimer concentrations with the clinical variables (heart rate, respiratory rate, mucous membranes color, capillary filling time, rectal temperature, pain degree, and time frame evolution) (hematocrit, total plasma protein, platelets, fibrinogen and blood leukocytes, as well as protein, fibrinogen, nucleated cells, bacteria and glucose in the peritoneal fluid) of horses with colic syndrome and with the diagnosis and prognosis of these cases. A total of 86 horses with a median age of 6.5 years and with a median weight of 400 kg were used. The animals were submitted to clinical examination and collection of blood and peritoneal fluid (LP) samples at admission. Plasma and peritoneal concentrations of D-dimers were evaluated by a semi-quantitative latex agglutination assay. Although plasma and peritoneal concentrations of D-dimers demonstrated a biological significance related to the severity of colic cases in the descriptive analysis, this was not statistically demonstrated through multivariate analysis. Therefore, we concluded that the determination of plasma and peritoneal concentrations of D-dimers using semi-quantitative latex agglutinati... (Complete abstract click electronic access below)
Mestre
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Alonso, Juliana de Moura [UNESP]. "Avaliação da reatividade peritoneal de equinos submetidos à enterotomia de cólon menor e tratados com heparina pela via subcutânea." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/89147.
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000760136.pdf: 3009097 bytes, checksum: ab6e7c1fbf6f7224e3b942dec747e608 (MD5)As afecções do cólon menor são causas frequentes de síndrome cólica, sendo a enterotomia rotineiramente empregada para a remoção de fecalitos, enterólitos e corpos estranhos. O trauma cirúrgico resulta em inflamação difusa e ocorrência de peritonite asséptica devido à manipulação e ao acesso cirúrgico. Objetivou-se estudar a reatividade peritoneal após a realização de enterotomia e abrasão do cólon menor em equinos tratados ou não com heparina sistêmica. Foram utilizados dez equinos com idade média de 9 ± 3,87anos e 358 ± 30,28 Kg de massa corporal, divididos em dois grupos de cinco animais, sendo um grupo o controle (GC) e o outro tratado (GT). Ambos os grupos foram submetidos à laparotomia e enterotomia de cólon menor através da via paralombar direita em posição quadrupedal e receberam flunixin meglumine, gentamicina e associação de penicilinas. Ao GT, acrescentou-se heparina (150 UI/Kg SC, BID, 5 dias). Os animais foram avaliados quanto ao exame físico; hemograma; fibrinogênio; coagulograma; proteínas de fase aguda, séricas e peritoneais; características macroscópicas, físico-químicas e citológicas do líquido peritoneal; concentrações peritoneais do ativador e inibidor do plasminogênio tecidual e dímero D. Para tanto, pradonizaram-se os seguintes momentos de avaliação: M0-prévio à enterotomia; M1-12 horas; M2 - 1dia, M3- 2dias, M4- 4dias e M5- 6 dias; M6- 10 dias e M7- 14 dias após a enterotomia. Observou-se que a heparina resultou em anemia e diminuição da contagem de plaquetas, aumento do tempo de tromboplastina parcial ativada e aumento nas concentrações séricas e peritoneais das proteínas de fase aguda, entretanto diminuiu a formação de dímeros D, sugerindo diminuição da formação de coágulos de fibrina. Após 15 dias da enterotomia, realizou-se o exame laparoscópico, que não demonstrou diferença na deposição de fibrina entre os grupos, entretanto...
Small colon affections are frequent causes of abdominal pain, and enterotomy is routinely employed for removal of fecalith, enteroliths and foreign bodies. Surgical trauma results in diffuse inflammation and aseptic peritonitis occurrence due to handling and surgical access. The aim of this study was to evaluate peritoneal reactivity after small colon enterotomy and abrasion in horses treated or not with systemic heparin. Were used ten horses with a mean age of 9 ± 3.87 years and 358 ± 30,28 body weight, divided into two groups of five animals: one control group (CG) and the other treated (TG). Both groups underwent laparotomy and small colon enterotomy via right paralumbar flank in standing position and received flunixin meglumine, gentamicin and penicillin association. TG received also heparin (150 IU / kg SC BID, 5 days). Animals were evaluated for physiological parameters, hemogram, fibrinogen, coagulation markers, serum and peritoneal acute phase proteins, peritoneal fluid macroscopic, physico-chemical and cytological characteristics, peritoneal concentrations of tissue plasminogen activator and inhibitor and d-dimer. Assessments were performed prior to enterotomy-M0, M1-12 hours after enterotomy; M2 - 1 day, M3 - 2days; M4 - 4days; M5 - 6 days; M6-10 days and M7 - 14 days after the enterotomy. Heparin resulted in anemia and decreased platelet counts, increased in partial thromboplastin activated time and increased serum and peritoneal acute phase proteins, however, resulted in decreased formation of fibrin clots and d dimer formation. After 15 days of enterotomy, laparoscopic examination showed no difference in fibrin deposition between the groups, and a slight diffuse peritoneal reactivity higher to treated group. So, heparin showed as negative effect the development of anemia, significant decrease in platelet count and acting as a proinflammatory agent, however shown to reduce fibrin deposition and formation ...
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Alonso, Juliana de Moura. "Avaliação da reatividade peritoneal de equinos submetidos à enterotomia de cólon menor e tratados com heparina pela via subcutânea /." Botucatu, 2013. http://hdl.handle.net/11449/89147.
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Orientador: Carloa Alberto HussniBanca: Armen Thomassian
Banca: Luis Cláudio Lopes Corrêa da Silva
Resumo: As afecções do cólon menor são causas frequentes de síndrome cólica, sendo a enterotomia rotineiramente empregada para a remoção de fecalitos, enterólitos e corpos estranhos. O trauma cirúrgico resulta em inflamação difusa e ocorrência de peritonite asséptica devido à manipulação e ao acesso cirúrgico. Objetivou-se estudar a reatividade peritoneal após a realização de enterotomia e abrasão do cólon menor em equinos tratados ou não com heparina sistêmica. Foram utilizados dez equinos com idade média de 9 ± 3,87anos e 358 ± 30,28 Kg de massa corporal, divididos em dois grupos de cinco animais, sendo um grupo o controle (GC) e o outro tratado (GT). Ambos os grupos foram submetidos à laparotomia e enterotomia de cólon menor através da via paralombar direita em posição quadrupedal e receberam flunixin meglumine, gentamicina e associação de penicilinas. Ao GT, acrescentou-se heparina (150 UI/Kg SC, BID, 5 dias). Os animais foram avaliados quanto ao exame físico; hemograma; fibrinogênio; coagulograma; proteínas de fase aguda, séricas e peritoneais; características macroscópicas, físico-químicas e citológicas do líquido peritoneal; concentrações peritoneais do ativador e inibidor do plasminogênio tecidual e dímero D. Para tanto, pradonizaram-se os seguintes momentos de avaliação: M0-prévio à enterotomia; M1-12 horas; M2 - 1dia, M3- 2dias, M4- 4dias e M5- 6 dias; M6- 10 dias e M7- 14 dias após a enterotomia. Observou-se que a heparina resultou em anemia e diminuição da contagem de plaquetas, aumento do tempo de tromboplastina parcial ativada e aumento nas concentrações séricas e peritoneais das proteínas de fase aguda, entretanto diminuiu a formação de dímeros D, sugerindo diminuição da formação de coágulos de fibrina. Após 15 dias da enterotomia, realizou-se o exame laparoscópico, que não demonstrou diferença na deposição de fibrina entre os grupos, entretanto ...
Abstract: Small colon affections are frequent causes of abdominal pain, and enterotomy is routinely employed for removal of fecalith, enteroliths and foreign bodies. Surgical trauma results in diffuse inflammation and aseptic peritonitis occurrence due to handling and surgical access. The aim of this study was to evaluate peritoneal reactivity after small colon enterotomy and abrasion in horses treated or not with systemic heparin. Were used ten horses with a mean age of 9 ± 3.87 years and 358 ± 30,28 body weight, divided into two groups of five animals: one control group (CG) and the other treated (TG). Both groups underwent laparotomy and small colon enterotomy via right paralumbar flank in standing position and received flunixin meglumine, gentamicin and penicillin association. TG received also heparin (150 IU / kg SC BID, 5 days). Animals were evaluated for physiological parameters, hemogram, fibrinogen, coagulation markers, serum and peritoneal acute phase proteins, peritoneal fluid macroscopic, physico-chemical and cytological characteristics, peritoneal concentrations of tissue plasminogen activator and inhibitor and d-dimer. Assessments were performed prior to enterotomy-M0, M1-12 hours after enterotomy; M2 - 1 day, M3 - 2days; M4 - 4days; M5 - 6 days; M6-10 days and M7 - 14 days after the enterotomy. Heparin resulted in anemia and decreased platelet counts, increased in partial thromboplastin activated time and increased serum and peritoneal acute phase proteins, however, resulted in decreased formation of fibrin clots and d dimer formation. After 15 days of enterotomy, laparoscopic examination showed no difference in fibrin deposition between the groups, and a slight diffuse peritoneal reactivity higher to treated group. So, heparin showed as negative effect the development of anemia, significant decrease in platelet count and acting as a proinflammatory agent, however shown to reduce fibrin deposition and formation ...
Mestre
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Araujo, Graziela Silveira. "Avaliação de alguns parametros da fibrinolise e do fator XIII em pacientes com trombose venosa profunda espontanea e doença hemorragica." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310159.
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Orientador: Joyce Maria Annichino-BizzacchiDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: Em uma parcela de pacientes com quadro clínico hemorrágico ou trombótico, nenhum diagnóstico etiológico é estabelecido. Os pacientes com doença hemorrágica, muitas vezes importante, podem apresentar todos os exames de triagem e dosagem específica de fatores da coagulação dentro dos valores da normalidade. OBS.: O resumo na integra poderá ser visualizado no link ou texto completo da tese digital
Abstract: In a parcel of patients with hemorrhagic or thrombotic clinical picture, none etiologic diagnosis is established. The patients with hemorrhagic desorder, many times important, can present all inside the screening tests and specific dosage of factors of the coagulation of the values of normality. Note: the complete abstract is avaiable with the link or full eletronic digital theses or dissertations
Mestrado
Biologia Estrutural, Celular, Molecular e do Desenvolvimento
Mestre em Fisiopatologia Médica
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De, Lange Zelda. "Global fibrinolytic potential of black South Africans in the North West Province / Z. de Lange." Thesis, North-West University, 2013. http://hdl.handle.net/10394/9645.
Full textAbstract:
INTRODUCTION AND AIM
The prevalence of cardiovascular disease (CVD) has increased significantly in the black South African population in recent years. Early in the development of CVD, atherosclerotic plaques form in the vessel wall. When this plaque becomes unstable and ruptures, the coagulation cascade is activated and a blood clot forms. The function of this clot is to stop bleeding. However, it cannot remain in the vasculature indefinitely and has to be lysed again. The ability of the body to lyse clots can be measured with global fibrinolytic potential (GFP) assays and expressed as lysis time. Increased clot lysis time (CLT) has been shown to be significantly associated with various CVD risk factors and CVD events in Caucasian populations while very little information is available for other ethnicities. In this study we investigated plasma GFP and its relation to CVD risk factors in a large black African population. We also determined the effect of three polymorphisms in the promoter area of the plasminogen activator inhibitor-1 (PAI-1) gene on PAI-1act (activity) levels (a main determinant of CLT) and CLT, together with gene-environment interactions and the effect of urbanisation on these interactions.
PARTICIPANTS AND METHODS
Apparently healthy men and women between the ages of 35 and 65 years were recruited to take part in the South African arm of the Prospective Urban and Rural Epidemiology (PURE) study. Approximately 1000 rural and 1000 urban black African individuals participated. Data and samples were collected during a 12-week collection period in 2005 for cross-sectional analysis.
RESULTS
Increased PAI-1act levels, body mass index (BMI), glycosylated haemoglobin (HbA1c), triglycerides, fibrinogen concentration, C-reactive protein, female sex, positive HIV-status and the metabolic syndrome were all associated with prolonged CLTs, while increased habitual alcohol consumption was associated with shorter iv
CLTs. Urban-rural differences for CLT existed in women only. This is likely due to the larger extent of rural-urban differences in other CVD risk factors observed in women compared to what was observed in men. Of the CVD risk factors measured, PAI-1 explained the largest proportion of the variance in CLT (27%). Owing to the important role PAI-1act plays in CLT, we investigated three polymorphisms in the PAI-1 gene promoter area (the 4G/5G polymorphism, the novel SNP C428T and SNP G429A (previously identified)), and the influence of these polymorphisms on PAI-1act levels and CLT. The frequency of the 5G allele was high (0.85) in comparison with previously reported literature. PAI-1act increased significantly across genotypes in the urban (5G/5G: 3.84 U/ml; 4G/5G: 4.85 U/ml; 4G/4G: 5.96 U/ml p=0.009) but not the rural subgroup, while CLT did not differ. We found significant interactions between the 4G/5G polymorphism and BMI, waist circumference and triglycerides in determining PAI-1act, and between the 4G/5G polymorphism and fibrinogen and fibrinogen gamma prime in determining CLT. Direct relationships with PAI-1act or CLT were not found for the C428T and G429A polymorphisms; they did, however, influence associations of other environmental factors with PAI-1act and CLT. Several of these interactions differed significantly between rural and urban subgroups, particularly in individuals harbouring the mutant alleles.
CONCLUSION
CLT associated with many of the same CVD risk factors described in the literature for Caucasian populations, but also with other risk factors. Rural-urban differences in CLT are dependent on the association of CLT with other CVD risk factors in the rural-urban setting. Genetic polymorphisms of the PAI-1 gene did not directly influence CLT, despite influencing PAI-1act. The main contributor to PAI-1act variance, however, was (central) obesity. The effect of the 4G/5G polymorphism on PAI-1act, as well as gene–environment interactions for the C428T and G429A genotypes in determining PAI-1act and CLT, were significantly influenced by urbanisation.Thesis (PhD (Nutrition))--North-West University, Potchefstroom Campus, 2013.
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Santos, Izabela Ribeiro. "Avaliação dos níveis de TAFI (inibidor da fibrinolise ativado pela trombina), do PAI-1 (inibidor do ativador do plasminogênio tipo 1) e frequência de seus polimorfismos na dislipidemia." Universidade Federal de Minas Gerais, 2013. http://hdl.handle.net/1843/BUOS-9C6GDL.
Full textAbstract:
Cardiovascular diseases are a public health concern with high morbidity and mortality, affected by risk factors such as diabetes mellitus, smoking, physical inactivity, hypertension, obesity and dyslipidemia. Dyslipidemia is defined as alterations in lipid metabolism that change the levels of lipoproteins, constituting a major risk factor for atherosclerosis and its complications. Moreover, it affects the haemostatic system, especially in the fibrinolysis. Several proteins comprising the fibrinolytic system regulates fibrinolysis by acting indirectly on the degradation of the fibrin clot, specially the inhibitor by Thrombin Activatable Fibrinolysis Inhibitor (TAFI) and Plasminogen Activator Inhibitor type 1 (PAI-1). Increased levels of TAFI have been associated with cardiovascular events, as well as increased serum PAI-1, which is already considered as a risk factor for such events. This study evaluated the association of acquired risk factors, the polymorphisms Thr325Ile, Ala147Thr and +1542C/G in the TAFI gene and 4G/5G in the PAI-1 gene and its plasma levels with dyslipidemia through the investigation of 109 dyslipidemic and 105 normolipemic individuals. We conducted analyses of biochemical and lipidic profile, as well as hemostatic parameters (TAFI and PAI-1 by ELISA) and molecular analysis using Polymerase Chain Reaction (PCR) to verify the genotypic and allelic frequencies for the polymorphisms studied. It was observed that hypertension, increased body mass index and menopause are more common in dyslipidemic individuals and they have higher TAFI levels. The alleles 325Ile, Ala147 and C showed association with lower TAFI levels. Ala147Thr and Thr325Ile polymorphisms are independently associated with dyslipidemia in males. The 4G/5G polymorphism and PAI-1 levels were not related with the disease. The results suggest that only TAFI may be independently associated with dyslipidemia.As doenças cardiovasculares constituem um problema de saúde pública, com morbidade e mortalidade elevadas, afetadas por fatores de risco associados, como o diabetes mellitus, tabagismo, sedentarismo, hipertensão arterial, obesidade e as dislipidemias. Estas se definem como alterações do metabolismo lipídico que modificam os níveis das lipoproteínas, constituindo um dos principais fatores de risco para a aterosclerose e suas complicações. A dislipidemia influencia o sistema hemostático, especialmente na redução da fibrinólise. Várias proteínas compõem o sistema fibrinolítico e regulam a fibrinólise ao atuarem indiretamente na degradação do coágulo de fibrina, em especial o Inibidor da Fibrinólise Ativado pela Trombina (TAFI) e o Inibidor do Ativador do Plasminogênio Tipo 1 (PAI-1). Níveis aumentados de TAFI têm sido associados aos eventos cardiovasculares, assim como o aumento da concentração plasmática de PAI-1, o qual já é considerado, na literatura, como um fator de risco para estes eventos. Este estudo avaliou a associação de fatores de risco adquiridos, dos polimorfismos Thr325Ile, Ala147Thr e +1542C/G no gene TAFI e 4G/5G no gene PAI-1 e seus níveis plasmáticos com a dislipidemia investigando 109 indivíduos dislipidêmicos e 105 normolipêmicos. Foram realizadas análises bioquímicas do perfil lipídico e análises hemostáticas dos parâmetros TAFI e PAI-1 pelo método de ELISA, bem como análises moleculares, pela técnica de Reação em Cadeia da Polimerase (PCR), para verificar as frequências genotípicas e alélicas para os polimorfismos estudados. Foi observado que, dentre os fatores de risco, a hipertensão, o aumento do índice de massa corporal e a menopausa são mais frequentes em indivíduos dislipidêmicos e estes possuem maiores níveis de TAFI. Os alelos 325Ile, Ala147 e C foram associados a menores níveis plasmáticos da proteína. Os polimorfismos Thr325Ile e Ala147Thr demonstraram associação independente com a dislipidemia em indivíduos do sexo masculino. Para o polimorfismo 4G/5G e os níveis de PAI-1 não foi encontrada a mesma relação com a doença. Os resultados sugerem que apenas o TAFI está associado independente à dislipidemia.
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Moraes, Samira Lauar de. "Estudo de alguns parametros da coagulação e fibrinolise no hipertireoidismo e hipotireoidismo : avaliação da importancia da via beta adrenergico nas alterações dos fatores VIII e de von Willebrand em modelos experimentais." [s.n.], 1996. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310162.
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Orientador: Joyce Maria Annichino BizzacchiDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Não informado
Abstract: Although clinically important abnormalities of hemostasis are unusual in patients with thyroid disease, coagulation and fibrinolytic systems are, nonetheless affected by hormone alterations. Patients with hypothyroidism may present abnormal bleeding. The precise nature of the "ohemostatic defect was explained by a decrease in several coagulation factors, an increase in fibrinolytic activity and an abnormal platelet adhesiveness. If the hypercoagulable state contributes to increase the risk of thromboembolic complications in hypothyroid patients, the relatively increased fibrinolytic activity in such patients probably has a protective role. Although precise statistics are not available, thromboembolic disorders do not seem to be common in patients with hyperthyroidism. These' patients showed a specific elevation of the factors VIII and von Willebrand and a reduction in plasma fibrinolytic activity. Maybe, hyperdynamic circulation may counterbalance these potential hypercoagulable changes. One of the hypothesis for elevated anti-hemophilic factor activity in hyperthyroidism is based on the fact that epinephrine infusion in normal subjects is followed by elevated levels of hemostasis changes that have been reported and not yet adequately explained. The aim of this study was to evaluate components of contact phase, coagulation, natural factor VIII activity, and hyperthyroid subjects which have an increased sensitivity to the etfects of cathecolamines. An experimental model with dogs before and after hypothyroidism induction was performed in order to study the importance of the f3 adrenergic receptors in levels of factor VIII and von Willebrand. During the clinic phase ofthis study, we analyzed 33 untreated hyperthyroid patients (mean age 39:!:13 years old), 20 hypothyroid patients (mean age 23:t6 years). Ali patients were female. Twenty nine female euthyroid subjects (mean age 48:!:18 years) were the control Group. The following was analyzed: activated Partial Thromboplastin Time (APTT), Prothrombin Time (TP), Thrombin Time (TT), Factors V, Vil, VIll , XI and XII, Fibrinogen, Protein C (PC), Protein S (PS), Cl-inhibitor (C 1), alpha 2-macroglobulin (alpha-2), prealbumin and von Willebrand factor, Plasmatic prekallikrein (PK), triiodothyronine (T3 ), tetraiodothyronine (T 4) total and tree, TSH and TSHus. Only ~actor XII and the a. 2-macroglobulin were decreased during the contact phase in hypothyroid patients. We do not believe that tlfts decrease in factor XII levels is due to the reduction on protein synthesis. We have determined other coagulation factors; they are more sensitive to alterations in hepatic proteins synthesis, like factor Vil and PK. They were not altered in hypothyroid patients. The decrease of a. 2 macroglobulin in hypothyroid patients could represent a regulatory mechanism against fybrinolysis. Both factor VIII and von Willebrand were increased in hyperthyroid patients. These factors were similar in the hypothyroid and the control group. Final common pathway parameters and fibrinogen did not show a significant difference between the three groups...Note: The complete abstract is available with the full electronic digital thesis or dissertations
Mestrado
Clinica Medica
Mestre em Medicina
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Tremblay, Isabelle. "Érythropoïétine et fibrinolyse intrarénale /." Thèse, Trois-Rivières : Université du Québec à Trois-Rivières, 1999. http://www.uqtr.ca/biblio/notice/resume/03-2200554R.html.
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Tremblay, Isabelle. "Érythropoïétine et fibrinolyse intrarénale." Thèse, Université du Québec à Trois-Rivières, 1999. http://depot-e.uqtr.ca/3585/1/000658989.pdf.
Full textBooks on the topic "Fibrinolise"
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Fibrinolysis, thrombosis, and hemostasis: Concepts, perspectives, and clinical applications. Philadelphia: Lea & Febiger, 1992.
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NATO Advanced Research Workshop on Regulation of Extravascular Fibrinolysis in Nervous System Development and Disease (1989 Maratea, Italy). Serine proteases and their serpin inhibitors in the nervous system: Regulation in development and in degenerative and malignant disease. Edited by Festoff Barry W, Hantaï Daniel, and North Atlantic Treaty Organization. Scientific Affairs Division. New York: Plenum Press, 1990.
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Glas-Greenwalt, Pia. Fibrinolysis in Disease - The Malignant Process, Interventions in Thrombogenic Mechanisms, and Novel Treatment Modalities, Volume 2. CRC, 1995.
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Pia, Glas-Greenwalt, ed. Fibrinolysis in disease: Molecular and hemovascular aspects of fibrinolysis. Boca Raton, Fla: CRC Press, 1996.
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Raymond, Sawaya, ed. Fibrinolysis and the central nervous system. Philadelphia: Hanley & Belfus, 1990.
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J, Comerota Anthony, ed. Thrombolytic therapy for peripheral vascular disease. Philadelphia: Lippincott, 1995.
Find full textBook chapters on the topic "Fibrinolise"
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Roeren, T., and M. Düx. "Lokale Fibrinolyse." In Röntgenfibel, 369–77. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-97561-5_21.
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Roeren, Th, and M. Düx. "Lokale Fibrinolyse." In Gefäßintervention, 68–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-662-07398-8_5.
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Goldyn, Gerd L. "Fibrinolyse und Thrombektomie." In Praxishandbuch Angiographie, 185–200. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44891-5_5.
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Heinrich, Fritz. "Fibrinolyse der Lungenembolie." In Thrombosen und Embolien: Arzthaftung, 165–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-78297-8_14.
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Böttiger, B. W. "Fibrinolyse bei Reanimation." In Fachübergreifende Aspekte der Hämostaseologie II, 121–36. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60626-7_11.
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Goldyn, Gerd L. "Fibrinolyse und Thrombektomie." In Praxishandbuch Angiographie, 157–70. Heidelberg: Steinkopff, 2003. http://dx.doi.org/10.1007/978-3-7985-1765-3_5.
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Schwenk, W., and B. Böhm. "Die intravasale Fibrinolyse." In Das Pneumoperitoneum, 187–200. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-59713-8_10.
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Schubring, C., J. Grulich-Henn, S. Bauer, and G. Müller-Berghaus. "Fibrinolyse bei prämenopausaler Hysterektomie." In Gynäkologie und Geburtshilfe 1992, 460–61. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77857-5_173.
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Müller-Berghaus, G. "Physiologie der Blutgerinnung und Fibrinolyse." In Transfusionsmedizin, 53–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-662-10601-3_4.
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Vervloet, M. G., L. G. Thijs, C. E. Hack, and H. P. Schuster. "Störungen der Blutgerinnung und Fibrinolyse." In Intensivtherapie bei Sepsis und Multiorganversagen, 289–309. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-07962-1_12.
Full textConference papers on the topic "Fibrinolise"
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Maier-Stocker, C., A. Georgescu, F. Kocheise, A. Kandulski, M. Selgrad, M. Müller, and S. Schmid. "Infektbedingte Pfortaderthrombose nach Gastroenteritis bei Leberzirrhose Child A: Erfolgreiche Therapie durch transjugulären portosystemischen Stent-Shunt (TIPS), mechanische Thrombektomie und lokale Fibrinolyse." In 46. Jahrestagung der Gesellschaft für Gastroenterologie in Bayern e.V. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1648577.
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